National Toxicology Program

National Toxicology Program
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TR 386 Rat Pathology Tables

NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11 
LAB: Midwest Research Inst                                     DATE: 09/09/94   
EXP: 05072                    TETRANITROMETHANE                TIME: 01:29:16   
TEST: 01              CAGES FROM 0000 TO LAST CAGE             PAGE:   1        
TEST TYPE: CHRONIC          ROUTE: RESPIRATORY EXPOSURE WHOLE  NTP C#: 55947    
CONT: N01ES38042                                               CAS: 509-14-8    
PATHOLOGIST: M. STEDHAM                                                         
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NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11
LAB: Midwest Research Inst                                     DATE: 09/09/94  
EXP: 05072                    TETRANITROMETHANE                TIME: 01:29:16  
TEST: 01              CAGES FROM 0000 TO LAST CAGE                             
TEST TYPE: CHRONIC          ROUTE: RESPIRATORY EXPOSURE WHOLE  NTP C#: 55947   
CONT: N01ES38042                                               CAS: 509-14-8   
PATHOLOGIST: M. STEDHAM                                                        

                                 TETRANITROMETHANE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE RATS
                       FIRST TERMINAL SACRIFICE AT 727 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = CONTROL                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 32     CENSORED DEATHS 0    TERMINAL 18        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      294   401   422   483   492   545   546   563   569   604                 |
 |      618   618   644   644   644   646   646   649   653   658                 |
 |      660   661   668   671   686   694   707   708   720   723                 |
 |      723   724                                                                 |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 2 PPM                                    |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 33     CENSORED DEATHS 0    TERMINAL 17        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      353   486   533   535   535   541   547   556   560   591                 |
 |      598   605   619   619   633   633   659   661   663   674                 |
 |      675   675   675   681   687   687   688   692   699   707                 |
 |      708   724   726                                                           |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 5 PPM                                    |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 46     CENSORED DEATHS 0    TERMINAL 4         |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      497   500   506   513   518   521   532   541   546   547                 |
 |      547   548   548   548   549   562   562   573   576   590                 |
 |      601   601   604   605   609   610   618   629   632   632                 |
 |      638   653   653   657   659   673   674   674   685   694                 |
 |      696   698   706   708   710   723                                         |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================

                                 TETRANITROMETHANE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE RATS
                       FIRST TERMINAL SACRIFICE AT 727 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   727 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |CONTROL    |   100.0 100.0 100.0  98.0  94.0  92.0  88.0  80.0  56.0  36.0      |
 |           |                                                                    |
 |           |                                                                    |
 |2 PPM      |   100.0 100.0 100.0  98.0  98.0  98.0  88.0  76.0  62.0  34.0      |
 |           |                                                                    |
 |           |                                                                    |
 |5 PPM      |   100.0 100.0 100.0 100.0 100.0 100.0  84.0  52.0  30.0   8.0      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                    DOSE                        |
 |                                                                                |
 |                                CONTROL          2 PPM            5 PPM         |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       36.0%            34.0%             8.0%         |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P<0.001          P=1.000          P<0.001       |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       615.1            625.0            605.8         |
 |NATURAL DEATHS (C)      |       (18.2)           (14.3)           ( 9.8)        |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       655.4            659.7            615.5         |
 |(STANDARD ERROR)        |       (13.9)           (11.6)           (10.2)        |
 |                        |                                                       |
 ==================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                                 TETRANITROMETHANE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE RATS
                       FIRST TERMINAL SACRIFICE AT 727 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = CONTROL                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 25     CENSORED DEATHS 0    TERMINAL 25        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      8     251   454   491   510   513   520   525   548   590                 |
 |      595   602   606   629   638   644   646   657   658   659                 |
 |      659   673   674   693   725                                               |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 2 PPM                                    |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 16     CENSORED DEATHS 0    TERMINAL 34        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      428   545   559   563   577   584   587   603   612   619                 |
 |      639   681   689   703   706   716                                         |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 5 PPM                                    |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 35     CENSORED DEATHS 0    TERMINAL 15        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      475   495   512   520   534   545   560   567   570   576                 |
 |      584   590   616   626   633   646   658   665   667   670                 |
 |      688   689   695   695   696   696   700   702   714   717                 |
 |      719   720   721   722   722                                               |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================

                                 TETRANITROMETHANE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE RATS
                       FIRST TERMINAL SACRIFICE AT 727 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   727 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |CONTROL    |    98.0  98.0  96.0  96.0  96.0  94.0  84.0  76.0  58.0  50.0      |
 |           |                                                                    |
 |           |                                                                    |
 |2 PPM      |   100.0 100.0 100.0 100.0 100.0  98.0  96.0  84.0  78.0  68.0      |
 |           |                                                                    |
 |           |                                                                    |
 |5 PPM      |   100.0 100.0 100.0 100.0 100.0  98.0  88.0  76.0  64.0  30.0      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                    DOSE                        |
 |                                                                                |
 |                                CONTROL          2 PPM            5 PPM         |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       50.0%            68.0%            30.0%         |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=0.077          P=0.080N         P=0.215       |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       566.7            613.2            637.3         |
 |NATURAL DEATHS (C)      |       (30.6)           (18.9)           (12.9)        |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       646.9            690.6            664.2         |
 |(STANDARD ERROR)        |       (19.0)           ( 9.6)           (10.7)        |
 |                        |                                                       |
 ==================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                                                         TETRANITROMETHANE
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        CONTROL          = 1
                                                        2 PPM            = 2
                                                        5 PPM            = 3

------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  100 + 1                                             1         2                     3
      |                                               1         2       1            233
      |                                                                 1  1        12 333   2
      |                                                                             1 1
   90 +                                                                               1  3 3 21
      |                                                                                    33 22
      |                                                                                     3 12211
      |                                                                                       332 1   2 1
   80 +                                                                                               221 1
      |                                                                                                22
      |                                                                                                 2 1  1
      |                                                                                                   2 2
P  70 +                                                                                        3 3           11
E     |                                                                                                     2    2
R     |                                                                                          333          11
C     |                                                                                            3  3          2 2
E  60 +                                                                                               33       1 1
N     |
T     |                                                                                                33        1122
      |                                                                                                           1 12
S  50 +                                                                                                 33          1 1
U     |                                                                                                  33           11
R     |                                                                                                   333        22111
V     |                                                                                                               22 11
I  40 +                                                                                                     33         22
V     |                                                                                                      3 3        2 2
A     |                                                                                                                   1
L     |                                                                                                        3 3
   30 +                                                                                                          3 3
      |
      |                                                                                                            33
      |                                                                                                             3 3
   20 +
      |
      |                                                                                                               333
      |
   10 +                                                                                                                 3 3
      |                                                                                                                   3
      |
      |
    0 +
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 14 obs hidden.

                                                         TETRANITROMETHANE
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        CONTROL          = 1
                                                        2 PPM            = 2
                                                        5 PPM            = 3

----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  100 + 1 1                                                                 2      3
      |   1                                     1                           2      3  3       2
      |                                         1                               1     1  3 3  2 22
      |                                                                               1 1  3 3   2 2
   90 +                                                                                 11   33    22
      |                                                                                  1 1  3 3
P     |                                                                                    1   1333 2   22
E     |                                                                                        1  33  1  22
R  80 +                                                                                            33     2  2
C     |                                                                                             3 11     2      2
E     |                                                                                               3113 1        22 2
N     |                                                                                                    131
T  70 +                                                                                                     3 3        2 2
      |                                                                                                      113         22
S     |                                                                                                       11 33
U     |                                                                                                        1 1
R  60 +                                                                                                           3  3
V     |                                                                                                          1 1
I     |                                                                                                            1 13
V     |                                                                                                              1    1
A  50 +                                                                                                                   1
L     |
      |                                                                                                               333
      |                                                                                                                 33
   40 +
      |
      |                                                                                                                  33
      |
   30 +                                                                                                                   3
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 19 obs hidden.

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