National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/3787

TR 387 Mouse Pathology Tables


                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                       DL AMPHETAMINE SULFATE


NTP Experiment-Test: 05029-02                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 09/04/94
Route: DOSED FEED                                                                                                 Time: 12:33:09




       Facility:  Microbiological Associates

       Chemical CAS #:  60-13-9

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05029-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       DL AMPHETAMINE SULFATE                                  Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 12:33:09  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        VEHICLE      LOW  M/F     HIGH M/F                                               
                                                   CONTROL      20PPM        100 PPM                                                
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Dead                                              10           11            5                                                  
    Moribund                                           5            3            1                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                35           36           44                                                  
  Animals Examined Microscopically                    50           50           47                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (44)         (40)         (43)                                                
      Inflammation, Chronic                            1 (2%)       1 (3%)                                                          
   Intestine Large, Cecum                             (44)         (44)         (44)                                                
      Hyperplasia, Lymphoid                            1 (2%)       5 (11%)                                                         
   Intestine Small, Jejunum                           (45)         (43)         (44)                                                
      Inflammation, Acute                              1 (2%)                                                                       
   Liver                                              (50)         (50)         (47)                                                
      Basophilic Focus                                 1 (2%)                                                                       
      Cytologic Alterations, Focal                     1 (2%)                                                                       
      Hematopoietic Cell Proliferation                 4 (8%)       5 (10%)                                                         
      Inflammation, Acute                              3 (6%)       1 (2%)       1 (2%)                                             
      Inflammation, Chronic                            7 (14%)     11 (22%)      7 (15%)                                            
      Mitotic Alteration                                                         1 (2%)                                             
      Necrosis                                         3 (6%)       2 (4%)       1 (2%)                                             
      Vacuolization Cytoplasmic                        5 (10%)                                                                      
      Serosa, Inflammation, Acute                      1 (2%)       1 (2%)                                                          
   Mesentery                                          (4)          (1)                                                              
      Infiltration Cellular, Lymphocyte                             1 (100%)                                                        
      Inflammation, Acute                              1 (25%)                                                                      
      Fat, Necrosis                                    3 (75%)                                                                      
   Pancreas                                           (49)         (48)         (45)                                                
      Cyst                                             1 (2%)                                                                       
      Inflammation, Acute                              2 (4%)       3 (6%)                                                          
      Inflammation, Chronic                                         7 (15%)      5 (11%)                                            
      Acinus, Atrophy, Focal                           2 (4%)                                                                       
      Acinus, Necrosis                                 1 (2%)                                                                       
      Acinus, Vacuolization Cytoplasmic                             2 (4%)       1 (2%)                                             
      Artery, Inflammation, Acute                                   1 (2%)                                                          
   Salivary Glands                                    (49)         (46)         (43)                                                
      Infiltration Cellular, Lymphocyte               26 (53%)     25 (54%)     21 (49%)                                            
      Artery, Inflammation, Acute                                   1 (2%)                                                          
   Stomach, Forestomach                               (50)         (49)         (46)                                                
      Inflammation, Acute                              1 (2%)                                                                       
      Epithelium, Hyperplasia                          2 (4%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05029-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       DL AMPHETAMINE SULFATE                                  Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 12:33:09  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        VEHICLE      LOW  M/F     HIGH M/F                                               
                                                   CONTROL      20PPM        100 PPM                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
   Stomach, Glandular                                 (50)         (49)         (46)                                                
      Erosion                                                                    1 (2%)                                             
      Infiltration Cellular, Lymphocyte                             1 (2%)                                                          
      Inflammation, Chronic                                         1 (2%)                                                          
      Ulcer                                            1 (2%)                                                                       
   Tooth                                              (2)          (2)          (1)                                                 
      Inflammation, Acute                              2 (100%)     1 (50%)      1 (100%)                                           
      Inflammation, Chronic                                         1 (50%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (47)                                                
      Fibrosis                                                      2 (4%)                                                          
      Aortic Valve, Thrombosis                                      1 (2%)                                                          
      Epicardium, Inflammation, Acute                               2 (4%)                                                          
      Myocardium, Inflammation, Chronic                             1 (2%)                                                          
      Myocardium, Inflammation, Chronic Active         1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (50)         (46)         (47)                                                
      Capsule, Hyperplasia                            50 (100%)    42 (91%)     46 (98%)                                            
   Adrenal Gland, Cortex                              (50)         (46)         (46)                                                
      Cyst                                             2 (4%)                                                                       
      Hematopoietic Cell Proliferation                              2 (4%)                                                          
      Infiltration Cellular, Lymphocyte                             1 (2%)                                                          
      Inflammation, Acute                                           1 (2%)                                                          
      Inflammation, Chronic                                         1 (2%)                                                          
      Vacuolization Cytoplasmic                        1 (2%)                                                                       
   Adrenal Gland, Medulla                             (48)         (43)         (43)                                                
      Hyperplasia                                                   1 (2%)                                                          
   Parathyroid Gland                                  (46)         (42)         (44)                                                
      Infiltration Cellular, Lymphocyte                                          1 (2%)                                             
   Pituitary Gland                                    (49)         (49)         (46)                                                
      Pars Distalis, Angiectasis                       1 (2%)                                                                       
      Pars Distalis, Hyperplasia                      11 (22%)      5 (10%)      3 (7%)                                             
      Pars Intermedia, Pigmentation                    1 (2%)                                                                       
   Thyroid Gland                                      (50)         (49)         (47)                                                
      Cyst                                             8 (16%)      9 (18%)     10 (21%)                                            
      Inflammation, Acute                              2 (4%)                                                                       
      Inflammation, Chronic                            1 (2%)       1 (2%)       1 (2%)                                             
      Follicular Cell, Hyperplasia                     8 (16%)      5 (10%)      3 (6%)                                             
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05029-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       DL AMPHETAMINE SULFATE                                  Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 12:33:09  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        VEHICLE      LOW  M/F     HIGH M/F                                               
                                                   CONTROL      20PPM        100 PPM                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (49)         (48)         (46)                                                
      Abscess                                          2 (4%)                                                                       
      Atrophy                                         14 (29%)     12 (25%)     25 (54%)                                            
      Cyst                                            11 (22%)     16 (33%)     12 (26%)                                            
      Hemorrhage                                       3 (6%)       1 (2%)                                                          
      Infiltration Cellular, Lymphocyte                             2 (4%)                                                          
      Inflammation, Acute                              1 (2%)       4 (8%)                                                          
      Inflammation, Chronic                                         1 (2%)                                                          
   Uterus                                             (50)         (50)         (47)                                                
      Abscess                                          2 (4%)                                                                       
      Hemorrhage                                                                 1 (2%)                                             
      Inflammation, Acute                              8 (16%)     10 (20%)      4 (9%)                                             
      Artery, Inflammation, Acute                                   1 (2%)       1 (2%)                                             
      Cervix, Inflammation, Chronic                    1 (2%)                                                                       
      Endometrium, Hyperplasia, Cystic                35 (70%)     34 (68%)     34 (72%)                                            
      Endometrium, Necrosis                                                      1 (2%)                                             
      Serosa, Inflammation, Acute                      1 (2%)                                                                       
      Serosa, Inflammation, Chronic                    1 (2%)       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (47)                                                
      Hyperplasia                                      6 (12%)      6 (12%)                                                         
   Lymph Node                                         (50)         (49)         (47)                                                
      Iliac, Hyperplasia, Lymphoid                     2 (4%)                                                                       
      Mediastinal, Abscess                             1 (2%)                                                                       
   Lymph Node, Mandibular                             (47)         (43)         (41)                                                
      Cyst                                                          1 (2%)                                                          
      Hematopoietic Cell Proliferation                 1 (2%)                                                                       
      Hyperplasia, Lymphoid                            1 (2%)       1 (2%)       1 (2%)                                             
      Pigmentation                                                  1 (2%)                                                          
      Thrombosis                                       1 (2%)                                                                       
      Lymphocyte, Necrosis                                          1 (2%)                                                          
   Lymph Node, Mesenteric                             (50)         (46)         (40)                                                
      Dilatation                                       1 (2%)                                                                       
      Hematopoietic Cell Proliferation                 2 (4%)                                                                       
      Hyperplasia, Lymphoid                            8 (16%)      4 (9%)       1 (3%)                                             
      Lymphocyte, Necrosis                             1 (2%)       2 (4%)                                                          
   Spleen                                             (50)         (49)         (46)                                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05029-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       DL AMPHETAMINE SULFATE                                  Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 12:33:09  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        VEHICLE      LOW  M/F     HIGH M/F                                               
                                                   CONTROL      20PPM        100 PPM                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Amyloid Deposition                               1 (2%)                                                                       
      Hematopoietic Cell Proliferation                 8 (16%)      5 (10%)      1 (2%)                                             
      Hyperplasia, Lymphoid                            6 (12%)      5 (10%)      2 (4%)                                             
      Lymphocyte, Necrosis                             1 (2%)       1 (2%)                                                          
   Thymus                                             (46)         (46)         (45)                                                
      Atrophy                                          8 (17%)      1 (2%)      14 (31%)                                            
      Inflammation, Acute                                           1 (2%)                                                          
      Mineralization                                                1 (2%)                                                          
      Necrosis                                                      1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (50)         (50)         (47)                                                
      Abscess                                          1 (2%)                                                                       
      Foreign Body                                                  1 (2%)                                                          
      Inflammation, Acute                              1 (2%)                                                                       
      Inflammation, Chronic                            1 (2%)       2 (4%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (47)                                                
      Fibrous Osteodystrophy                          18 (36%)     11 (22%)     11 (23%)                                            
      Metatarsal, Inflammation, Acute                  1 (2%)                                                                       
   Skeletal Muscle                                                 (5)          (1)                                                 
      Inflammation, Acute                                           1 (20%)                                                         
      Inflammation, Chronic                                         2 (40%)                                                         
      Artery, Inflammation, Acute                                   1 (20%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (49)         (47)                                                
      Infiltration Cellular, Lymphocyte                1 (2%)       1 (2%)       3 (6%)                                             
      Thrombosis                                                    1 (2%)                                                          
      Meninges, Infiltration Cellular, Lymphocyte      1 (2%)       3 (6%)       2 (4%)                                             
      Thalamus, Mineralization                        14 (28%)      7 (14%)     17 (36%)                                            
   Spinal Cord                                        (49)         (46)         (43)                                                
      Meninges, Infiltration Cellular, Lymphocyte      1 (2%)       7 (15%)      8 (19%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05029-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       DL AMPHETAMINE SULFATE                                  Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 12:33:09  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        VEHICLE      LOW  M/F     HIGH M/F                                               
                                                   CONTROL      20PPM        100 PPM                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (47)                                                
      Congestion                                       1 (2%)                    3 (6%)                                             
      Hemorrhage                                       1 (2%)       1 (2%)                                                          
      Hyperplasia, Adenomatous                         1 (2%)       2 (4%)                                                          
      Infiltration Cellular                            1 (2%)                                                                       
      Infiltration Cellular, Lymphocyte               29 (58%)     36 (72%)     36 (77%)                                            
      Infiltration Cellular, Histiocyte                1 (2%)       3 (6%)       1 (2%)                                             
      Inflammation, Chronic                                         1 (2%)                                                          
      Metaplasia, Osseous                              1 (2%)                                                                       
      Alveolar Epithelium, Hyperplasia, Adenomatous    1 (2%)                    1 (2%)                                             
      Interstitium, Inflammation, Subacute                                       1 (2%)                                             
      Pleura, Inflammation, Acute                      1 (2%)       2 (4%)                                                          
   Nose                                               (50)         (50)         (47)                                                
      Hemorrhage                                       1 (2%)                                                                       
      Nasolacrimal Duct, Inflammation                  1 (2%)                                                                       
      Nasolacrimal Duct, Inflammation, Acute                                     1 (2%)                                             
      Sinus, Inflammation, Acute                                                 1 (2%)                                             
   Trachea                                            (50)         (50)         (47)                                                
      Inflammation, Acute                              1 (2%)                                                                       
      Artery, Inflammation, Chronic                                              1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (47)         (44)         (45)                                                
      Cataract                                         1 (2%)                                                                       
      Cornea, Inflammation, Acute                                   2 (5%)                                                          
   Harderian Gland                                    (7)          (2)                                                              
      Hyperplasia                                      1 (14%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (48)         (47)                                                
      Amyloid Deposition                                            1 (2%)                                                          
      Inflammation, Acute                                           2 (4%)                                                          
      Inflammation, Chronic                           16 (32%)     23 (48%)     14 (30%)                                            
      Glomerulus, Inflammation, Membranous                          1 (2%)                                                          
      Pelvis, Inflammation, Acute                      1 (2%)                                                                       
      Renal Tubule, Degeneration                                                 1 (2%)                                             
   Ureter                                                          (1)                                                              
      Inflammation, Acute                                           1 (100%)                                                        
   Urinary Bladder                                    (48)         (47)         (45)                                                
      Infiltration Cellular, Lymphocyte               18 (38%)     13 (28%)     11 (24%)                                            
      Inflammation, Acute                              1 (2%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05029-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       DL AMPHETAMINE SULFATE                                  Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 12:33:09  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        VEHICLE      LOW  M/F     HIGH M/F                                               
                                                   CONTROL      20PPM        100 PPM                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Artery, Inflammation, Acute                                                1 (2%)                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 05029-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       DL AMPHETAMINE SULFATE                                  Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 12:33:09  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          VEHICLE      LOW  M/F     HIGH M/F                                               
                                                   CONTROL      20PPM        100 PPM                                                
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Dead                                               2            1            1                                                  
    Accident                                                        1                                                               
  Survivors                                                                                                                         
    Terminal Sacrifice                                48           48           49                                                  
  Animals Examined Microscopically                    50           50           50                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (48)         (48)         (48)                                                
      Inflammation, Chronic                            2 (4%)                                                                       
   Intestine Large, Cecum                             (49)         (48)         (50)                                                
      Hyperplasia, Lymphoid                            1 (2%)                    2 (4%)                                             
   Intestine Large, Rectum                            (47)         (46)         (50)                                                
      Inflammation, Acute                                                        1 (2%)                                             
      Inflammation, Chronic Active                     1 (2%)                                                                       
   Intestine Small, Duodenum                          (49)         (48)         (50)                                                
      Hyperplasia, Lymphoid                                                      1 (2%)                                             
   Intestine Small, Ileum                             (49)         (48)         (50)                                                
      Amyloid Deposition                                            1 (2%)                                                          
      Hyperplasia, Lymphoid                            1 (2%)       1 (2%)                                                          
   Intestine Small, Jejunum                           (49)         (48)         (50)                                                
      Hyperplasia, Lymphoid                                         1 (2%)                                                          
      Inflammation, Chronic                                         1 (2%)                                                          
   Liver                                              (50)         (50)         (50)                                                
      Basophilic Focus                                 3 (6%)                                                                       
      Clear Cell Focus                                              1 (2%)                                                          
      Cyst                                                                       1 (2%)                                             
      Cytologic Alterations, Focal                     4 (8%)                    3 (6%)                                             
      Fibrosis, Focal                                  1 (2%)                                                                       
      Inflammation, Acute                                           1 (2%)       1 (2%)                                             
      Inflammation, Chronic                            8 (16%)      3 (6%)                                                          
      Necrosis, Focal                                  1 (2%)                                                                       
      Centrilobular, Vacuolization Cytoplasmic         1 (2%)                                                                       
   Mesentery                                          (1)          (3)                                                              
      Fat, Necrosis                                    1 (100%)     1 (33%)                                                         
   Pancreas                                           (50)         (50)         (50)                                                
      Inflammation, Chronic                            2 (4%)       1 (2%)       1 (2%)                                             
      Acinus, Inflammation, Chronic                    1 (2%)                                                                       
      Acinus, Vacuolization Cytoplasmic                                          1 (2%)                                             
   Salivary Glands                                    (50)         (50)         (49)                                                
      Infiltration Cellular, Lymphocyte               38 (76%)     27 (54%)     15 (31%)                                            
      Inflammation, Chronic Active                                               1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 05029-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       DL AMPHETAMINE SULFATE                                  Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 12:33:09  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          VEHICLE      LOW  M/F     HIGH M/F                                               
                                                   CONTROL      20PPM        100 PPM                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Artery, Inflammation, Chronic                    1 (2%)       3 (6%)                                                          
   Stomach, Glandular                                 (49)         (50)         (50)                                                
      Cyst                                             1 (2%)                                                                       
      Inflammation, Acute                                                        1 (2%)                                             
      Inflammation, Chronic                            1 (2%)                                                                       
   Tooth                                              (5)          (5)                                                              
      Developmental Malformation                       1 (20%)      4 (80%)                                                         
      Inflammation, Acute                              3 (60%)      1 (20%)                                                         
      Inflammation, Chronic Active                     1 (20%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (1)                                                                           
      Aorta, Inflammation, Chronic                     1 (100%)                                                                     
   Heart                                              (50)         (50)         (50)                                                
      Inflammation, Chronic                                         1 (2%)                                                          
      Atrium, Bacterium                                                          1 (2%)                                             
      Atrium, Thrombosis                                                         1 (2%)                                             
      Myocardium, Infarct                                                        1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (50)         (49)         (49)                                                
      Capsule, Hyperplasia                            28 (56%)     32 (65%)     36 (73%)                                            
   Adrenal Gland, Cortex                              (50)         (49)         (49)                                                
      Hyperplasia                                      2 (4%)       3 (6%)                                                          
      Hypertrophy                                      3 (6%)       1 (2%)                                                          
      Hypertrophy, Focal                               5 (10%)      2 (4%)       2 (4%)                                             
      Capsule, Hyperplasia                             1 (2%)                                                                       
   Islets, Pancreatic                                 (50)         (50)         (50)                                                
      Hyperplasia                                      1 (2%)       1 (2%)                                                          
   Parathyroid Gland                                  (42)         (44)         (41)                                                
      Cyst                                                                       1 (2%)                                             
   Pituitary Gland                                    (48)         (49)         (50)                                                
      Pars Distalis, Cyst                              1 (2%)       2 (4%)       1 (2%)                                             
      Pars Distalis, Hyperplasia                                    1 (2%)                                                          
   Thyroid Gland                                      (50)         (50)         (50)                                                
      Cyst                                             7 (14%)      6 (12%)      7 (14%)                                            
      Inflammation, Chronic                                         1 (2%)                                                          
      Follicular Cell, Hyperplasia                     1 (2%)       1 (2%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    9                                                              
NTP Experiment-Test: 05029-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       DL AMPHETAMINE SULFATE                                  Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 12:33:09  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          VEHICLE      LOW  M/F     HIGH M/F                                               
                                                   CONTROL      20PPM        100 PPM                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (50)         (50)                                                
      Inflammation, Chronic                            1 (2%)       2 (4%)       3 (6%)                                             
   Preputial Gland                                    (1)                       (1)                                                 
      Cyst                                             1 (100%)                                                                     
      Inflammation, Acute                                                        1 (100%)                                           
   Prostate                                           (50)         (50)         (49)                                                
      Inflammation, Chronic                                         3 (6%)       2 (4%)                                             
   Seminal Vesicle                                    (50)         (50)         (50)                                                
      Inflammation, Acute                                                        1 (2%)                                             
      Inflammation, Chronic                                         1 (2%)                                                          
   Testes                                             (50)         (50)         (50)                                                
      Atrophy                                                       3 (6%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node                                         (50)         (50)         (50)                                                
      Hyperplasia, Lymphoid                            1 (2%)       1 (2%)                                                          
   Lymph Node, Mandibular                             (41)         (44)         (45)                                                
      Hyperplasia, Lymphoid                                                      2 (4%)                                             
   Lymph Node, Mesenteric                             (47)         (49)         (48)                                                
      Amyloid Deposition                                            1 (2%)                                                          
      Hematopoietic Cell Proliferation                 2 (4%)                                                                       
      Hemorrhage                                       2 (4%)       1 (2%)                                                          
      Hyperplasia, Lymphoid                            4 (9%)       4 (8%)                                                          
   Spleen                                             (48)         (50)         (50)                                                
      Depletion Lymphoid                               1 (2%)                                                                       
      Hematopoietic Cell Proliferation                                           1 (2%)                                             
      Hyperplasia, Lymphoid                            1 (2%)       1 (2%)                                                          
   Thymus                                             (44)         (44)         (41)                                                
      Cyst                                             2 (5%)                    1 (2%)                                             
      Epithelial Cell, Hyperplasia                                  1 (2%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (50)         (50)         (50)                                                
      Inflammation, Acute                                           2 (4%)                                                          
      Inflammation, Chronic                            2 (4%)                    1 (2%)                                             
      Subcutaneous Tissue, Abscess                                  1 (2%)                                                          
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   10                                                              
NTP Experiment-Test: 05029-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       DL AMPHETAMINE SULFATE                                  Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 12:33:09  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          VEHICLE      LOW  M/F     HIGH M/F                                               
                                                   CONTROL      20PPM        100 PPM                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - CONT                                                                                                         
      Tail, Inflammation, Chronic                      1 (2%)                                                                       
      Tail, Epidermis, Cyst                                                      1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)                                                
      Fibrous Osteodystrophy                           1 (2%)                    1 (2%)                                             
      Osteomalacia                                                  1 (2%)                                                          
      Cranium, Hyperostosis                                         1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)                                                
      Infiltration Cellular, Lymphocyte                1 (2%)                                                                       
      Choroid Plexus, Infiltration Cellular,                                                                                        
          Lymphocyte                                                             1 (2%)                                             
      Meninges, Infiltration Cellular, Lymphocyte                   1 (2%)                                                          
      Thalamus, Mineralization                        43 (86%)     33 (66%)     36 (72%)                                            
   Spinal Cord                                        (49)         (50)         (50)                                                
      Infiltration Cellular, Lymphocyte                1 (2%)                                                                       
      Meninges, Infiltration Cellular, Lymphocyte                   3 (6%)       4 (8%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                             (50)         (50)         (50)                                                
      Inflammation, Acute                              1 (2%)                                                                       
   Lung                                               (50)         (50)         (50)                                                
      Congestion                                       1 (2%)                                                                       
      Fibrosis, Focal                                                            1 (2%)                                             
      Hemorrhage                                                    2 (4%)                                                          
      Hyperplasia, Adenomatous                         3 (6%)       3 (6%)                                                          
      Infiltration Cellular, Lymphocyte               39 (78%)     30 (60%)     33 (66%)                                            
      Infiltration Cellular, Histiocyte                4 (8%)                                                                       
      Inflammation, Acute                                           1 (2%)                                                          
      Pigmentation                                     1 (2%)                                                                       
      Alveolar Epithelium, Hyperplasia, Adenomatous    1 (2%)                    1 (2%)                                             
      Interstitium, Inflammation, Chronic              1 (2%)                                                                       
   Nose                                               (50)         (50)         (50)                                                
      Glands, Inflammation, Acute                                                1 (2%)                                             
      Nasolacrimal Duct, Inflammation, Acute           2 (4%)                                                                       
      Sinus, Hemorrhage                                             1 (2%)                                                          
      Sinus, Inflammation, Acute                       2 (4%)       1 (2%)                                                          
      Turbinate, Inflammation, Chronic                              1 (2%)                                                          
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   11                                                              
NTP Experiment-Test: 05029-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       DL AMPHETAMINE SULFATE                                  Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 12:33:09  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          VEHICLE      LOW  M/F     HIGH M/F                                               
                                                   CONTROL      20PPM        100 PPM                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (49)         (49)         (50)                                                
      Cornea, Inflammation, Chronic                    1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)                                                
      Cyst                                             2 (4%)       3 (6%)       1 (2%)                                             
      Fibrosis, Focal                                  1 (2%)                                                                       
      Inflammation, Chronic                           34 (68%)     25 (50%)     27 (54%)                                            
      Metaplasia, Osseous                              1 (2%)       1 (2%)                                                          
      Artery, Inflammation, Chronic                                 1 (2%)                                                          
      Cortex, Cyst                                     1 (2%)                                                                       
      Cortex, Necrosis, Focal                                       1 (2%)                                                          
      Papilla, Bacterium                                                         1 (2%)                                             
      Papilla, Necrosis                                                          1 (2%)                                             
      Pelvis, Dilatation                                            1 (2%)                                                          
      Renal Tubule, Hyperplasia                                     1 (2%)                                                          
      Renal Tubule, Regeneration                       1 (2%)                                                                       
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   12                                                              
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------                                           

--multipart-boundary
Content-type: text/plain
Range: bytes 74493-74493/74493


--multipart-boundary--
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.