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TR 387 Mouse Pathology Tables


                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                       DL AMPHETAMINE SULFATE


NTP Experiment-Test: 05029-02                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 09/04/94
Route: DOSED FEED                                                                                                 Time: 12:33:13




       Facility:  Microbiological Associates

       Chemical CAS #:  60-13-9

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05029-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                       DL AMPHETAMINE SULFATE                                  Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 12:33:13  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        VEHICLE      LOW  M/F     HIGH M/F                                               
                                                   CONTROL      20PPM        100 PPM                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Dead                                              10           11            5                                                  
    Moribund                                           5            3            1                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                35           36           44                                                  
  Animals Examined Microscopically                    50           50           47                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (44)         (44)         (44)                                                
   Intestine Small, Jejunum                           (45)         (43)         (44)                                                
   Liver                                              (50)         (50)         (47)                                                
      Hemangiosarcoma                                               1 (2%)                                                          
      Hepatocellular Adenoma                           5 (10%)      1 (2%)       1 (2%)                                             
      Histiocytic Sarcoma                              1 (2%)       2 (4%)                                                          
   Pancreas                                           (49)         (48)         (45)                                                
      Histiocytic Sarcoma                                           1 (2%)                                                          
   Salivary Glands                                    (49)         (46)         (43)                                                
   Stomach, Forestomach                               (50)         (49)         (46)                                                
      Squamous Cell Papilloma                          1 (2%)                                                                       
   Stomach, Glandular                                 (50)         (49)         (46)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (47)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (46)         (46)                                                
   Adrenal Gland, Medulla                             (48)         (43)         (43)                                                
      Histiocytic Sarcoma                                           1 (2%)                                                          
      Pheochromocytoma Benign                                       1 (2%)                                                          
   Parathyroid Gland                                  (46)         (42)         (44)                                                
   Pituitary Gland                                    (49)         (49)         (46)                                                
      Pars Distalis, Adenoma                          12 (24%)      6 (12%)      1 (2%)                                             
      Pars Intermedia, Adenoma                         1 (2%)                                                                       
   Thyroid Gland                                      (50)         (49)         (47)                                                
      Follicular Cell, Adenoma                         1 (2%)       1 (2%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                             Page   2                                                               
NTP Experiment-Test: 05029-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                       DL AMPHETAMINE SULFATE                                  Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 12:33:13  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        VEHICLE      LOW  M/F     HIGH M/F                                               
                                                   CONTROL      20PPM        100 PPM                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (49)         (48)         (46)                                                
      Cystadenoma                                      1 (2%)       1 (2%)                                                          
      Granulosa Cell Tumor Benign                                   1 (2%)                                                          
      Hemangiosarcoma                                  1 (2%)                                                                       
      Histiocytic Sarcoma                                           1 (2%)                                                          
      Neoplasm NOS                                                               1 (2%)                                             
   Uterus                                             (50)         (50)         (47)                                                
      Histiocytic Sarcoma                                           2 (4%)                                                          
      Cervix, Fibrosarcoma                                          1 (2%)                                                          
      Cervix, Leiomyoma                                1 (2%)                                                                       
      Endometrium, Polyp Stromal                       2 (4%)       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (47)                                                
   Lymph Node                                         (50)         (49)         (47)                                                
      Mediastinal, Histiocytic Sarcoma                 1 (2%)                                                                       
   Lymph Node, Mandibular                             (47)         (43)         (41)                                                
      Histiocytic Sarcoma                              2 (4%)                                                                       
   Lymph Node, Mesenteric                             (50)         (46)         (40)                                                
      Histiocytic Sarcoma                              1 (2%)                                                                       
   Spleen                                             (50)         (49)         (46)                                                
      Hemangiosarcoma                                  1 (2%)       1 (2%)                                                          
      Histiocytic Sarcoma                              1 (2%)       3 (6%)                                                          
   Thymus                                             (46)         (46)         (45)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (48)         (45)                                                
      Adenocarcinoma                                                1 (2%)       1 (2%)                                             
      Adenoma                                          1 (2%)       1 (2%)                                                          
   Skin                                               (50)         (50)         (47)                                                
      Melanoma Benign                                                            1 (2%)                                             
      Subcutaneous Tissue, Fibrosarcoma                1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   3                                                               
NTP Experiment-Test: 05029-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                       DL AMPHETAMINE SULFATE                                  Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 12:33:13  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        VEHICLE      LOW  M/F     HIGH M/F                                               
                                                   CONTROL      20PPM        100 PPM                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (47)                                                
      Joint, Neoplasm NOS                                           1 (2%)                                                          
   Skeletal Muscle                                                 (5)          (1)                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (49)         (47)                                                
   Spinal Cord                                        (49)         (46)         (43)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Larynx                                             (50)         (49)         (47)                                                
   Lung                                               (50)         (50)         (47)                                                
      Alveolar/Bronchiolar Adenoma                     7 (14%)      4 (8%)       1 (2%)                                             
      Alveolar/Bronchiolar Carcinoma                   1 (2%)       2 (4%)                                                          
      Fibrosarcoma, Metastatic, Skin                   1 (2%)                                                                       
      Fibrous Histiocytoma, Metastatic, Ear            1 (2%)                                                                       
      Histiocytic Sarcoma                              1 (2%)       1 (2%)                                                          
   Nose                                               (50)         (50)         (47)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                (1)          (1)                                                              
      Pinna, Fibrous Histiocytoma                      1 (100%)                                                                     
   Harderian Gland                                    (7)          (2)                                                              
      Adenoma                                          5 (71%)      2 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (48)         (47)                                                
      Histiocytic Sarcoma                              1 (2%)       3 (6%)                                                          
   Urinary Bladder                                    (48)         (47)         (45)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(47)                                                
      Histiocytic Sarcoma                              2 (4%)       3 (6%)                                                          
      Lymphoma Malignant                               1 (2%)                    1 (2%)                                             
      Lymphoma Malignant Histiocytic                   4 (8%)                                                                       
      Lymphoma Malignant Lymphocytic                   1 (2%)       1 (2%)       2 (4%)                                             
      Lymphoma Malignant Mixed                        10 (20%)      9 (18%)      7 (15%)                                            
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   4                                                               
NTP Experiment-Test: 05029-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                       DL AMPHETAMINE SULFATE                                  Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 12:33:13  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        VEHICLE      LOW  M/F     HIGH M/F                                               
                                                   CONTROL      20PPM        100 PPM                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SYSTEMIC LESIONS - cont                                                                                                            
   Multiple Organs                                   *(50)        *(50)        *(47)                                                
      Lymphoma Malignant Undifferentiated Cell                                   1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                             Page   5                                                               
NTP Experiment-Test: 05029-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                       DL AMPHETAMINE SULFATE                                  Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 12:33:13  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        VEHICLE      LOW  M/F     HIGH M/F                                               
                                                   CONTROL      20PPM        100 PPM                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            40          27          15                                                   
     Total Primary Neoplasms                           60          39          18                                                   
                                                                                                                                    
   Total Animals with Benign Neoplasms                 30          13           5                                                   
     Total Benign Neoplasms                            37          19           5                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms              19          17          11                                                   
     Total Malignant Neoplasms                         23          19          12                                                   
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              2                                                                           
     Total Metastatic Neoplasm                          2                                                                           
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                              1           1                                                   
     Total Uncertain Neoplasms                                      1           1                                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   6                                                               
NTP Experiment-Test: 05029-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                       DL AMPHETAMINE SULFATE                                  Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 12:33:13  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          VEHICLE      LOW  M/F     HIGH M/F                                               
                                                   CONTROL      20PPM        100 PPM                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Dead                                               2            1            1                                                  
    Accident                                                        1                                                               
  Survivors                                                                                                                         
    Terminal Sacrifice                                48           48           49                                                  
  Animals Examined Microscopically                    50           50           50                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (48)         (48)         (48)                                                
      Adenoma, Papillary                               1 (2%)                    1 (2%)                                             
   Intestine Large, Cecum                             (49)         (48)         (50)                                                
   Intestine Small, Duodenum                          (49)         (48)         (50)                                                
   Intestine Small, Ileum                             (49)         (48)         (50)                                                
   Intestine Small, Jejunum                           (49)         (48)         (50)                                                
      Carcinoma                                                     1 (2%)                                                          
   Liver                                              (50)         (50)         (50)                                                
      Hemangiosarcoma                                  3 (6%)       1 (2%)                                                          
      Hemangiosarcoma, Multiple                                                  1 (2%)                                             
      Hepatocellular Carcinoma                         4 (8%)       5 (10%)      1 (2%)                                             
      Hepatocellular Carcinoma, Multiple                            1 (2%)                                                          
      Hepatocellular Adenoma                          10 (20%)      7 (14%)      1 (2%)                                             
   Mesentery                                          (1)          (3)                                                              
      Hemangiosarcoma                                               1 (33%)                                                         
   Pancreas                                           (50)         (50)         (50)                                                
   Salivary Glands                                    (50)         (50)         (49)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (50)         (49)         (49)                                                
      Capsule, Adenoma                                 4 (8%)       1 (2%)                                                          
   Adrenal Gland, Cortex                              (50)         (49)         (49)                                                
      Adenoma                                                       1 (2%)                                                          
   Adrenal Gland, Medulla                             (49)         (49)         (47)                                                
      Neuroblastoma Benign                                          1 (2%)                                                          
      Pheochromocytoma Benign                                       1 (2%)       1 (2%)                                             
                                                             Page   7                                                               
NTP Experiment-Test: 05029-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                       DL AMPHETAMINE SULFATE                                  Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 12:33:13  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          VEHICLE      LOW  M/F     HIGH M/F                                               
                                                   CONTROL      20PPM        100 PPM                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - cont                                                                                                             
   Islets, Pancreatic                                 (50)         (50)         (50)                                                
      Adenoma                                          1 (2%)                                                                       
   Thyroid Gland                                      (50)         (50)         (50)                                                
      Follicular Cell, Adenoma                                                   2 (4%)                                             
      Follicular Cell, Carcinoma                                    1 (2%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (50)         (50)                                                
   Seminal Vesicle                                    (50)         (50)         (50)                                                
   Testes                                             (50)         (50)         (50)                                                
      Interstitial Cell, Adenoma                                                 1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node                                         (50)         (50)         (50)                                                
   Lymph Node, Mandibular                             (41)         (44)         (45)                                                
   Lymph Node, Mesenteric                             (47)         (49)         (48)                                                
   Spleen                                             (48)         (50)         (50)                                                
      Hemangiosarcoma                                  1 (2%)       1 (2%)                                                          
   Thymus                                             (44)         (44)         (41)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)                                                
   Spinal Cord                                        (49)         (50)         (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   8                                                               
NTP Experiment-Test: 05029-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                       DL AMPHETAMINE SULFATE                                  Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 12:33:13  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          VEHICLE      LOW  M/F     HIGH M/F                                               
                                                   CONTROL      20PPM        100 PPM                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)                                                
      Alveolar/Bronchiolar Adenoma                     6 (12%)      2 (4%)       3 (6%)                                             
      Alveolar/Bronchiolar Carcinoma                   2 (4%)       1 (2%)       1 (2%)                                             
      Alveolar/Bronchiolar Carcinoma, Multiple         1 (2%)                                                                       
      Hepatocellular Carcinoma, Metastatic, Liver      2 (4%)       3 (6%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (4)          (2)                                                              
      Adenoma                                          4 (100%)     2 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)                                                
      Renal Tubule, Adenoma                                         1 (2%)                                                          
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)                                                
      Lymphoma Malignant Histiocytic                                             1 (2%)                                             
      Lymphoma Malignant Mixed                         4 (8%)       5 (10%)      4 (8%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   9                                                               
NTP Experiment-Test: 05029-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                       DL AMPHETAMINE SULFATE                                  Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 12:33:13  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          VEHICLE      LOW  M/F     HIGH M/F                                               
                                                   CONTROL      20PPM        100 PPM                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            30          25          18                                                   
     Total Primary Neoplasms                           41          33          18                                                   
                                                                                                                                    
   Total Animals with Benign Neoplasms                 23          15           9                                                   
     Total Benign Neoplasms                            26          16           9                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms              13          17           9                                                   
     Total Malignant Neoplasms                         15          17           9                                                   
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              2           3                                                               
     Total Metastatic Neoplasm                          2           3                                                               
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  10                                                               
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