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TR 387 Mouse Pathology Tables

NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11 
LAB: Microbiological Assoc.                                    DATE: 09/04/94   
EXP: 05029                  DL AMPHETAMINE SULFATE             TIME: 12:43:17   
TEST: 02              CAGES FROM 0000 TO LAST CAGE             PAGE:   1        
TEST TYPE: CHRONIC          ROUTE: DOSED FEED                  NTP C#: 55710    
CONT: N01CP9565001                                             CAS: 60-13-9     
PATHOLOGIST: W. HALL                         S. EUSTIS                          
--------------------------------------------------------------------------------
                                                                                
                                                                                
                                                                                


REASONS FOR REMOVAL:                                                            
                                                                                
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REMOVAL DATE RANGE:                                                             


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NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11
LAB: Microbiological Assoc.                                    DATE: 09/04/94  
EXP: 05029                  DL AMPHETAMINE SULFATE             TIME: 12:43:17  
TEST: 02              CAGES FROM 0000 TO LAST CAGE                             
TEST TYPE: CHRONIC          ROUTE: DOSED FEED                  NTP C#: 55710   
CONT: N01CP9565001                                             CAS: 60-13-9    
PATHOLOGIST: W. HALL                         S. EUSTIS                         

                              DL AMPHETAMINE SULFATE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 729 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                          DOSE = VEHICLE CONTROL                                |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 2      CENSORED DEATHS 0    TERMINAL 48        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      36    383                                                                 |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = LOW  M/F20PPM                                  |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 1      CENSORED DEATHS 1    TERMINAL 48        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      695                                                                       |
 |  CENSORED DEATHS                                                               |
 |      6                                                                         |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = HIGH M/F100 PPM                                |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 1      CENSORED DEATHS 0    TERMINAL 49        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      624                                                                       |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================

                              DL AMPHETAMINE SULFATE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 729 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   729 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |VEHICLE    |    98.0  98.0  98.0  98.0  96.0  96.0  96.0  96.0  96.0  96.0      |
 |CONTROL    |                                                                    |
 |           |                                                                    |
 |LOW        |   100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0  98.0      |
 |M/F20PPM   |                                                                    |
 |           |                                                                    |
 |HIGH       |   100.0 100.0 100.0 100.0 100.0 100.0 100.0 100.0  98.0  98.0      |
 |M/F100 PPM |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                    DOSE                        |
 |                                                                                |
 |                                VEHICLE          LOW              HIGH          |
 |                                CONTROL          M/F20PPM         M/F100 PPM    |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       96.0%            98.0%            98.0%         |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=0.986N         P=1.000N         P=0.986N      |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       209.5            695.0            624.0         |
 |NATURAL DEATHS (C)      |       ( 174)           (  . )           (  . )        |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       708.2            713.9            726.9         |
 |(STANDARD ERROR)        |       (15.4)           (14.5)           ( 2.1)        |
 |                        |                                                       |
 ==================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                              DL AMPHETAMINE SULFATE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 732 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                          DOSE = VEHICLE CONTROL                                |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 15     CENSORED DEATHS 0    TERMINAL 35        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      519   527   534   579   603   632   632   671   681   686                 |
 |      687   699   711   711   728                                               |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = LOW  M/F20PPM                                  |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 14     CENSORED DEATHS 0    TERMINAL 36        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      495   497   511   613   634   643   646   654   690   700                 |
 |      701   704   704   716                                                     |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = HIGH M/F100 PPM                                |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 6      CENSORED DEATHS 0    TERMINAL 44        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      253   253   555   687   708   724                                         |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================

                              DL AMPHETAMINE SULFATE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 732 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   732 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |VEHICLE    |   100.0 100.0 100.0 100.0 100.0 100.0  94.0  90.0  86.0  70.0      |
 |CONTROL    |                                                                    |
 |           |                                                                    |
 |LOW        |   100.0 100.0 100.0 100.0 100.0 100.0  94.0  94.0  84.0  72.0      |
 |M/F20PPM   |                                                                    |
 |           |                                                                    |
 |HIGH       |   100.0 100.0  96.0  96.0  96.0  96.0  96.0  94.0  94.0  88.0      |
 |M/F100 PPM |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                    DOSE                        |
 |                                                                                |
 |                                VEHICLE          LOW              HIGH          |
 |                                CONTROL          M/F20PPM         M/F100 PPM    |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       70.0%            72.0%            88.0%         |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=0.035N         P=0.971N         P=0.051N      |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       640.0            636.3            530.0         |
 |NATURAL DEATHS (C)      |       (18.5)           (21.3)           (90.9)        |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       704.4            705.2            707.8         |
 |(STANDARD ERROR)        |       ( 8.1)           ( 8.5)           (13.8)        |
 |                        |                                                       |
 ==================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                                                       DL AMPHETAMINE SULFATE
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        VEHICLE CONTROL  = 1
                                                        LOW  M/F20PPM    = 2
                                                        HIGH M/F100 PPM  = 3

------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

        |
        |
  100.0 +1      1                                                                                           3          2
        |
        |
        |
   99.5 +
        |
        |
        |
P  99.0 +
E       |
R       |
C       |
E  98.5 +
N       |
T       |
        |
S  98.0 +       1                                                     1                                     3          2     2
U       |
R       |
V       |
I  97.5 +
V       |
A       |
L       |
   97.0 +
        |
        |
        |
   96.5 +
        |
        |
        |
   96.0 +                                                             1                                                      1
        |
        -+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+-
         0         10         20         30         40         50         60         70         80         90         100        110

                                                                    WEEK

NOTE: 3 obs hidden.

                                                       DL AMPHETAMINE SULFATE
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        VEHICLE CONTROL  = 1
                                                        LOW  M/F20PPM    = 2
                                                        HIGH M/F100 PPM  = 3

----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  100 + 1                                        3                                    2    1
      |
      |                                                                                    11
      |
   96 +                                          3                                    2 2   11  3
      |
      |                                                                                 2    1  3  1     2           3
      |
P  92 +                                                                                            1    12  2        3  3
E     |
R     |                                                                                                 1   12          3 3
C     |
E  88 +                                                                                                      22           3 3
N     |
T     |                                                                                                     1 22  1
      |
S  84 +                                                                                                        2  1 12
U     |
R     |                                                                                                              22
V     |
I  80 +                                                                                                             1122
V     |
A     |                                                                                                              11
L     |
   76 +                                                                                                               1 1
      |
      |                                                                                                                2 2
      |
   72 +                                                                                                                 121 2
      |
      |                                                                                                                   1 1
      |
   68 +
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 3 obs hidden.

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