National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/3834

TR 387 Rat Pathology Tables


                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                       DL AMPHETAMINE SULFATE


NTP Experiment-Test: 05029-01                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 09/04/94
Route: DOSED FEED                                                                                                 Time: 11:07:10




       Facility:  Microbiological Associates

       Chemical CAS #:  60-13-9

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05029-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                       DL AMPHETAMINE SULFATE                                  Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 11:07:10  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   VEHICLE      LOW  M/F     HIGH M/F                                               
                                                   CONTROL      20PPM        100 PPM                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Moribund                                          10            4            7                                                  
    Dead                                               7            4            6                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                33           42           37                                                  
  Animals Examined Microscopically                    50           50           50                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (49)         (49)         (50)                                                
      Osteosarcoma, Metastatic, Uncertain Primary                                                                                   
          Site                                         1 (2%)                                                                       
   Intestine Small, Ileum                             (47)         (50)         (50)                                                
      Leiomyosarcoma                                                             1 (2%)                                             
   Liver                                              (50)         (50)         (50)                                                
   Pancreas                                           (49)         (49)         (49)                                                
      Acinus, Carcinoma                                1 (2%)                                                                       
   Salivary Glands                                    (48)         (49)         (49)                                                
      Schwannoma Malignant                                                       1 (2%)                                             
   Tongue                                             (1)                                                                           
      Squamous Cell Papilloma                          1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (49)         (50)         (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (48)         (50)                                                
      Adenoma                                                       2 (4%)                                                          
   Adrenal Gland, Medulla                             (49)         (47)         (49)                                                
      Pheochromocytoma Benign                          2 (4%)       3 (6%)       2 (4%)                                             
      Pheochromocytoma Benign, Multiple                             1 (2%)                                                          
   Islets, Pancreatic                                 (50)         (48)         (50)                                                
      Carcinoma                                        1 (2%)       1 (2%)                                                          
   Parathyroid Gland                                  (45)         (44)         (47)                                                
      Adenoma                                                       1 (2%)                                                          
   Pituitary Gland                                    (50)         (48)         (50)                                                
      Pars Distalis, Adenoma                          31 (62%)     24 (50%)     19 (38%)                                            
      Pars Distalis, Carcinoma                                      2 (4%)                                                          
                                                             Page   2                                                               
NTP Experiment-Test: 05029-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                       DL AMPHETAMINE SULFATE                                  Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 11:07:10  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   VEHICLE      LOW  M/F     HIGH M/F                                               
                                                   CONTROL      20PPM        100 PPM                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - cont                                                                                                             
   Thyroid Gland                                      (50)         (50)         (50)                                                
      C-Cell, Adenoma                                  5 (10%)      2 (4%)       2 (4%)                                             
      Follicular Cell, Adenoma                                      2 (4%)                                                          
      Follicular Cell, Carcinoma                                    1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (39)         (37)         (39)                                                
      Adenoma                                          2 (5%)       1 (3%)                                                          
   Ovary                                              (50)         (50)         (50)                                                
   Uterus                                             (50)         (50)         (50)                                                
      Endometrium, Polyp Stromal                      10 (20%)      5 (10%)      3 (6%)                                             
      Endometrium, Polyp Stromal, Multiple                          1 (2%)                                                          
      Endometrium, Sarcoma Stromal                     1 (2%)                                                                       
   Vagina                                             (1)          (1)                                                              
      Sarcoma, Metastatic                              1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Blood                                                                        (1)                                                 
   Bone Marrow                                        (50)         (50)         (49)                                                
   Lymph Node, Mandibular                             (47)         (49)         (48)                                                
   Lymph Node, Mesenteric                             (46)         (49)         (49)                                                
   Spleen                                             (50)         (50)         (49)                                                
   Thymus                                             (45)         (47)         (47)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (48)         (49)         (47)                                                
      Adenocarcinoma                                   3 (6%)       1 (2%)       1 (2%)                                             
      Adenoma                                          2 (4%)       1 (2%)                                                          
      Fibroadenoma                                    17 (35%)     10 (20%)      2 (4%)                                             
      Fibroadenoma, Multiple                           4 (8%)       1 (2%)                                                          
   Skin                                               (50)         (50)         (50)                                                
      Lipoma                                                        1 (2%)                                                          
      Squamous Cell Papilloma                          1 (2%)                                                                       
      Sebaceous Gland, Papilloma                                    1 (2%)                                                          
      Subcutaneous Tissue, Fibroma                     2 (4%)                                                                       
      Subcutaneous Tissue, Fibrosarcoma                1 (2%)                                                                       
                                                             Page   3                                                               
NTP Experiment-Test: 05029-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                       DL AMPHETAMINE SULFATE                                  Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 11:07:10  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   VEHICLE      LOW  M/F     HIGH M/F                                               
                                                   CONTROL      20PPM        100 PPM                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - cont                                                                                                         
      Subcutaneous Tissue, Lipoma                                   1 (2%)                                                          
      Subcutaneous Tissue, Sarcoma                     1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)                                                
      Cerebrum, Astrocytoma Malignant                                            1 (2%)                                             
      Pons, Carcinoma, Metastatic                                   1 (2%)                                                          
   Spinal Cord                                        (50)         (49)         (49)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)                                                
      Alveolar/Bronchiolar Adenoma                                  3 (6%)       2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Zymbal's Gland                                     (1)                                                                           
      Carcinoma                                        1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)                                                
   Urinary Bladder                                    (50)         (48)         (50)                                                
      Leiomyoma                                                     1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)                                                
      Leukemia Mononuclear                             7 (14%)      8 (16%)      7 (14%)                                            
      Lymphoma Malignant Histiocytic                                1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   4                                                               
NTP Experiment-Test: 05029-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                       DL AMPHETAMINE SULFATE                                  Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 11:07:10  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   VEHICLE      LOW  M/F     HIGH M/F                                               
                                                   CONTROL      20PPM        100 PPM                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            48          42          30                                                   
     Total Primary Neoplasms                           93          75          41                                                   
                                                                                                                                    
   Total Animals with Benign Neoplasms                 42          36          23                                                   
     Total Benign Neoplasms                            77          61          30                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms              15          14          10                                                   
     Total Malignant Neoplasms                         16          14          11                                                   
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              2           1                                                               
     Total Metastatic Neoplasm                          2           1                                                               
                                                                                                                                    
   Total Animals with Malignant Neoplasms               1                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   5                                                               
NTP Experiment-Test: 05029-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                       DL AMPHETAMINE SULFATE                                  Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 11:07:10  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     VEHICLE      LOW  M/F     HIGH M/F                                               
                                                   CONTROL      20PPM        100 PPM                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Dead                                               8           11            9                                                  
    Moribund                                          12            8            8                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                30           31           33                                                  
  Animals Examined Microscopically                    50           50           50                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Small, Jejunum                           (49)         (49)         (46)                                                
      Adenocarcinoma                                   1 (2%)                                                                       
   Liver                                              (50)         (50)         (50)                                                
      Carcinoma, Metastatic, Testes                                 1 (2%)                                                          
      Neoplastic Nodule                                                          1 (2%)                                             
   Mesentery                                          (6)          (5)          (5)                                                 
      Fibrous Histiocytoma                                          1 (20%)                                                         
   Pancreas                                           (49)         (49)         (49)                                                
      Fibrous Histiocytoma                                          1 (2%)                                                          
   Salivary Glands                                    (50)         (48)         (50)                                                
      Schwannoma Malignant                             1 (2%)                    2 (4%)                                             
   Stomach, Glandular                                 (50)         (50)         (50)                                                
   Tooth                                                           (1)          (1)                                                 
      Gingiva, Neoplasm NOS                                         1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (49)         (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (49)         (48)         (50)                                                
      Adenoma                                                                    1 (2%)                                             
   Adrenal Gland, Medulla                             (49)         (44)         (50)                                                
      Pheochromocytoma Malignant                                                 1 (2%)                                             
      Pheochromocytoma Benign                         17 (35%)     10 (23%)      6 (12%)                                            
      Pheochromocytoma Benign, Multiple                6 (12%)      5 (11%)                                                         
   Islets, Pancreatic                                 (50)         (47)         (50)                                                
      Adenoma                                          1 (2%)       1 (2%)       1 (2%)                                             
      Carcinoma                                        1 (2%)       1 (2%)       2 (4%)                                             
   Parathyroid Gland                                  (41)         (39)         (49)                                                
                                                             Page   6                                                               
NTP Experiment-Test: 05029-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                       DL AMPHETAMINE SULFATE                                  Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 11:07:10  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     VEHICLE      LOW  M/F     HIGH M/F                                               
                                                   CONTROL      20PPM        100 PPM                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - cont                                                                                                             
      Adenoma                                                       1 (3%)                                                          
   Pituitary Gland                                    (49)         (48)         (49)                                                
      Pars Distalis, Adenoma                          15 (31%)     15 (31%)      9 (18%)                                            
   Thyroid Gland                                      (50)         (50)         (50)                                                
      C-Cell, Adenoma                                  9 (18%)      4 (8%)       5 (10%)                                            
      C-Cell, Adenoma, Multiple                        1 (2%)                                                                       
      C-Cell, Carcinoma                                3 (6%)                    1 (2%)                                             
      Follicle, Adenoma                                1 (2%)                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (50)         (50)                                                
   Preputial Gland                                    (48)         (47)         (49)                                                
      Adenoma                                          2 (4%)       5 (11%)      1 (2%)                                             
      Carcinoma                                                     1 (2%)       2 (4%)                                             
   Prostate                                           (49)         (49)         (50)                                                
      Adenoma                                                       1 (2%)                                                          
   Seminal Vesicle                                    (49)         (49)         (49)                                                
   Testes                                             (50)         (50)         (50)                                                
      Interstitial Cell, Adenoma                      10 (20%)     10 (20%)      4 (8%)                                             
      Interstitial Cell, Adenoma, Multiple            33 (66%)     33 (66%)     44 (88%)                                            
      Interstitial Cell, Carcinoma                                  1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)                                                
   Lymph Node                                         (50)         (50)         (50)                                                
   Lymph Node, Mandibular                             (48)         (45)         (49)                                                
   Lymph Node, Mesenteric                             (48)         (49)         (50)                                                
   Spleen                                             (50)         (49)         (50)                                                
      Carcinoma, Metastatic, Testes                                 1 (2%)                                                          
      Hemangioma                                                                 1 (2%)                                             
   Thymus                                             (39)         (45)         (43)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   7                                                               
NTP Experiment-Test: 05029-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                       DL AMPHETAMINE SULFATE                                  Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 11:07:10  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     VEHICLE      LOW  M/F     HIGH M/F                                               
                                                   CONTROL      20PPM        100 PPM                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (37)         (44)         (48)                                                
      Fibroadenoma                                     3 (8%)                                                                       
   Skin                                               (50)         (50)         (50)                                                
      Basal Cell Adenoma                                            1 (2%)                                                          
      Keratoacanthoma                                  1 (2%)       1 (2%)       1 (2%)                                             
      Squamous Cell Papilloma                          1 (2%)       1 (2%)       1 (2%)                                             
      Subcutaneous Tissue, Fibroma                     2 (4%)       3 (6%)       1 (2%)                                             
      Subcutaneous Tissue, Fibroma, Multiple           1 (2%)                                                                       
      Subcutaneous Tissue, Keratoacanthoma                          1 (2%)                                                          
      Subcutaneous Tissue, Neurofibrosarcoma           1 (2%)                                                                       
      Subcutaneous Tissue, Sarcoma                                  1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)                                                
      Femur, Osteosarcoma                                                        1 (2%)                                             
   Skeletal Muscle                                                 (1)                                                              
      Diaphragm, Fibrous Histiocytoma                               1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)                                                
      Cerebrum, Astrocytoma Malignant                                            1 (2%)                                             
   Spinal Cord                                        (50)         (50)         (50)                                                
      Nerve, Schwannoma Malignant                      1 (2%)       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)                                                
      Alveolar/Bronchiolar Adenoma                     3 (6%)       2 (4%)       2 (4%)                                             
      Alveolar/Bronchiolar Carcinoma                                3 (6%)                                                          
      Carcinoma, Metastatic, Preputial Gland                        1 (2%)                                                          
      Chordoma, Metastatic, Uncertain Primary Site                               1 (2%)                                             
      Fibrous Histiocytoma                                          1 (2%)                                                          
      Osteosarcoma, Metastatic, Uncertain Primary                                                                                   
          Site                                                                   1 (2%)                                             
   Nose                                               (50)         (50)         (50)                                                
      Squamous Cell Carcinoma                                       1 (2%)                                                          
      Mucosa, Squamous Cell Carcinoma                  2 (4%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   8                                                               
NTP Experiment-Test: 05029-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                       DL AMPHETAMINE SULFATE                                  Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 11:07:10  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     VEHICLE      LOW  M/F     HIGH M/F                                               
                                                   CONTROL      20PPM        100 PPM                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (50)         (50)         (48)                                                
   Zymbal's Gland                                                               (1)                                                 
      Carcinoma                                                                  1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)                                                
      Fibrous Histiocytoma                                          1 (2%)                                                          
      Liposarcoma                                      1 (2%)                                                                       
   Urinary Bladder                                    (50)         (49)         (50)                                                
      Transitional Epithelium, Papilloma               1 (2%)       1 (2%)                                                          
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)                                                
      Leukemia Mononuclear                            20 (40%)     16 (32%)     18 (36%)                                            
      Mesothelioma Malignant                           2 (4%)       1 (2%)       2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   9                                                               
NTP Experiment-Test: 05029-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                       DL AMPHETAMINE SULFATE                                  Date: 09/04/94  
Route: DOSED FEED                                                                                                 Time: 11:07:10  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     VEHICLE      LOW  M/F     HIGH M/F                                               
                                                   CONTROL      20PPM        100 PPM                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            49          50          49                                                   
     Total Primary Neoplasms                          140         127         110                                                   
                                                                                                                                    
   Total Animals with Benign Neoplasms                 48          45          49                                                   
     Total Benign Neoplasms                           107          95          79                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms              25          25          27                                                   
     Total Malignant Neoplasms                         33          31          31                                                   
                                                                                                                                    
   Total Animals with Metastatic Neoplasms                          2           3                                                   
     Total Metastatic Neoplasm                                      3           4                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                       2                                                   
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                              1                                                               
     Total Uncertain Neoplasms                                      1                                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  10                                                               
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