TR 387 Rat Pathology Tables
NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
Facility: BIORELIANCE
Chemical CAS #: 60-13-9
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
_____________________________________________________________________________________________________________________
| 7| 6| 6| 5| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 5| 7| 7| 7| 7| 4|
DAY ON TEST | 3| 9| 5| 4| 7| 3| 3| 3| 3| 1| 3| 3| 3| 3| 4| 3| 3| 1| 6| 9| 3| 3| 2| 1| 8|
| 1| 4| 5| 1| 8| 1| 1| 1| 1| 9| 1| 1| 1| 1| 7| 1| 1| 9| 6| 3| 1| 1| 6| 0| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + A|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 2 |
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer, Chronic | 3 |
|__________________________________________________________________________|
Intestine Small, Ileum | + + A + + + + + + + + + + + + + + + + + + + + + A|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + A + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | |
Fatty Change | 4 2 3 3 2 2 3 1|
Focal Cellular Change | X X X X X X X X X X X X X X X X X X X |
Granuloma | 2 |
Hematopoietic Cell Proliferation, | |
Multifocal | |
Hepatodiaphragmatic Nodule | X X X |
Hyperplasia, Multifocal | 4 |
Infiltration Cellular, Multifocal, | |
Lymphocyte | |
Inflammation, Chronic, Multifocal | 2 1 2 1 2 2 1 2 4 2 1 1 1 2 |
Bile Duct, Hyperplasia, Multifocal | 2 1 2 1 2 2 2 2 3 |
|__________________________________________________________________________|
Mesentery | + + + |
Fat, Necrosis | 4 3 3 |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 2
NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
_____________________________________________________________________________________________________________________
| 7| 6| 6| 5| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 5| 7| 7| 7| 7| 4|
DAY ON TEST | 3| 9| 5| 4| 7| 3| 3| 3| 3| 1| 3| 3| 3| 3| 4| 3| 3| 1| 6| 9| 3| 3| 2| 1| 8|
| 1| 4| 5| 1| 8| 1| 1| 1| 1| 9| 1| 1| 1| 1| 7| 1| 1| 9| 6| 3| 1| 1| 6| 0| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Metaplasia, Focal | 1 |
Acinus, Atrophy, Diffuse | 3 2 |
Acinus, Atrophy, Focal | 1 1 |
Acinus, Atrophy, Multifocal | 2 2 2 |
Acinus, Focal Cellular Change | 2 |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Diffuse, Squamous | 2 2 |
Hyperplasia, Focal, Squamous | |
Inflammation, Acute | 2 |
Ulcer, Multiple | 3 |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion, Focal | 2 |
|__________________________________________________________________________|
Tongue | + |
Abscess | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy, Multifocal | 1 2 1 1 1 1 1 2 1 2 2 1 2 2 1 |
Mineralization, Multifocal | 4 2|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Focal | 2 1 1 1 |
Degeneration, Multifocal | 2 |
Fibrosis, Focal | 2 |
Hematocyst | |
__________________________________________|__________________________________________________________________________|
Page 3
NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
_____________________________________________________________________________________________________________________
| 7| 6| 6| 5| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 5| 7| 7| 7| 7| 4|
DAY ON TEST | 3| 9| 5| 4| 7| 3| 3| 3| 3| 1| 3| 3| 3| 3| 4| 3| 3| 1| 6| 9| 3| 3| 2| 1| 8|
| 1| 4| 5| 1| 8| 1| 1| 1| 1| 9| 1| 1| 1| 1| 7| 1| 1| 9| 6| 3| 1| 1| 6| 0| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
Hematopoietic Cell Proliferation, | |
Multifocal | |
Hyperplasia, Focal | 1 1 1 2 |
Hyperplasia, Multifocal | 3 |
Necrosis, Multifocal | 2|
|__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 3 |
Hyperplasia, Multifocal | 4 4 |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + M + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis, Focal | 1 |
Pars Distalis, Cyst | 2 3 2 2 2 2|
Pars Distalis, Hyperplasia, Focal | 1 4 2 |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia, Diffuse | 1 |
C-Cell, Hyperplasia, Focal | 2 2 3 |
C-Cell, Hyperplasia, Multifocal | 1 2 1 2 1 1 |
Follicle, Cyst | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + + + M + + + + + + M + M M + M + + + + + +|
Ectasia | 2 |
Hyperplasia, Focal | 3 1 |
Hyperplasia | 2 |
Inflammation, Acute, Focal | |
Inflammation, Chronic, Focal | 1 |
Inflammation, Chronic, Multifocal | 2 2 |
__________________________________________|__________________________________________________________________________|
Page 4
NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
_____________________________________________________________________________________________________________________
| 7| 6| 6| 5| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 5| 7| 7| 7| 7| 4|
DAY ON TEST | 3| 9| 5| 4| 7| 3| 3| 3| 3| 1| 3| 3| 3| 3| 4| 3| 3| 1| 6| 9| 3| 3| 2| 1| 8|
| 1| 4| 5| 1| 8| 1| 1| 1| 1| 9| 1| 1| 1| 1| 7| 1| 1| 9| 6| 3| 1| 1| 6| 0| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X X 2 X |
Inflammation, Chronic, Multifocal | |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 3 |
Cervix, Cyst | 2 4 |
Cervix, Inflammation, Chronic | |
Cervix, Inflammation, Chronic Active | 4 |
Cervix, Metaplasia, Squamous | 3 |
Endometrium, Cyst, Multiple | 1 |
Endometrium, Hyperplasia | |
Lumen, Hemorrhage | |
|__________________________________________________________________________|
Vagina | + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 2 |
Hyperplasia | 2 2 2 2 3 2 2 |
Myelofibrosis, Multifocal | |
|__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 2 |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Lymphoid | 2 |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + M + + + + + M + + + + + + + + + + +|
Hemorrhage | 2 |
Hyperplasia, Lymphoid | 2 |
Infiltration Cellular, Histiocyte | 2 2 2 2 2 2 2 |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 2 |
Infarct | 1 2 |
__________________________________________|__________________________________________________________________________|
Page 5
NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
_____________________________________________________________________________________________________________________
| 7| 6| 6| 5| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 5| 7| 7| 7| 7| 4|
DAY ON TEST | 3| 9| 5| 4| 7| 3| 3| 3| 3| 1| 3| 3| 3| 3| 4| 3| 3| 1| 6| 9| 3| 3| 2| 1| 8|
| 1| 4| 5| 1| 8| 1| 1| 1| 1| 9| 1| 1| 1| 1| 7| 1| 1| 9| 6| 3| 1| 1| 6| 0| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
Pigmentation | 2 |
Lymphoid Follicle, Atrophy | 3 |
Lymphoid Follicle, Hyperplasia, Focal| 3 4 |
|__________________________________________________________________________|
Thymus | + + + + M + + + + + + + + + + + + + + + + + + M +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + M + + + + + + + + + + +|
Acinus, Hyperplasia, Focal | 2 |
Duct, Ectasia | 2 2 2 2 2 2 2 2 2 3 2 2 3 1 1 |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic | 3 |
Subcutaneous Tissue, Hemorrhage | |
Subcutaneous Tissue, Inflammation, | |
Chronic Active, Focal | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 3 2 |
Osteomalacia | 2|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cerebrum, Hydrocephalus | 2 |
Cerebrum, Infiltration Cellular, | |
Focal, Lymphocyte | |
Hypothalamus, Compression | 2 4 3 |
|__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 6
NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
_____________________________________________________________________________________________________________________
| 7| 6| 6| 5| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 5| 7| 7| 7| 7| 4|
DAY ON TEST | 3| 9| 5| 4| 7| 3| 3| 3| 3| 1| 3| 3| 3| 3| 4| 3| 3| 1| 6| 9| 3| 3| 2| 1| 8|
| 1| 4| 5| 1| 8| 1| 1| 1| 1| 9| 1| 1| 1| 1| 7| 1| 1| 9| 6| 3| 1| 1| 6| 0| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2|
Infiltration Cellular, Multifocal, | |
Histiocyte | 1 1 1 1 1 1 1 1 1 1 1 |
Alveolar Epithelium, Hyperplasia, | |
Focal | 2 |
Interstitium, Inflammation, Chronic, | |
Focal | |
Peribronchial, Hyperplasia, Lymphoid | |
Pleura, Inflammation, Chronic, Focal | 1 |
Pleura, Inflammation, Multifocal, | |
Proliferative | |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | |
Fungus | X |
Mucosa, Cytoplasmic Alteration, | |
Multifocal | 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Mucosa, Inflammation, Acute, | |
Multifocal | |
Mucosa, Inflammation, Chronic, | |
Multifocal | 1 |
Mucosa, Inflammation, Chronic Active,| |
Multifocal | |
Mucosa, Inflammation, Multifocal, | |
Subacute | 1 2 |
Mucosa, Metaplasia, Focal, Squamous | |
Nasolacrimal Duct, Inflammation, | |
Chronic | |
Nasolacrimal Duct, Inflammation, | |
Chronic Active | 2 2 |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Ear | |
__________________________________________|__________________________________________________________________________|
Page 7
NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
_____________________________________________________________________________________________________________________
| 7| 6| 6| 5| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 5| 7| 7| 7| 7| 4|
DAY ON TEST | 3| 9| 5| 4| 7| 3| 3| 3| 3| 1| 3| 3| 3| 3| 4| 3| 3| 1| 6| 9| 3| 3| 2| 1| 8|
| 1| 4| 5| 1| 8| 1| 1| 1| 1| 9| 1| 1| 1| 1| 7| 1| 1| 9| 6| 3| 1| 1| 6| 0| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lens, Cataract | 4 2 3 |
Retina, Atrophy | 1 1 1 4 2 1 2 |
Sclera, Metaplasia, Focal, Osseous | 2 1 1 1 1 1 1 |
Sclera, Metaplasia, Multifocal, | |
Osseous | 1 1 1 |
|__________________________________________________________________________|
Zymbal's Gland | + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Nephropathy, Chronic, Multifocal | 3 1 1 2 2 1 2 1 1 2 1 2 1 |
Papilla, Necrosis | 4|
Pelvis, Mineralization, Multifocal | 1 |
Renal Tubule, Pigmentation | 2 |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Subacute | 2|
Transitional Epithelium, Hyperplasia | 3|
__________________________________________|__________________________________________________________________________
Page 8
NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| |
DAY ON TEST | 3| 3| 3| 0| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 7| 3| 3| 3| 3| 7| |
| 1| 1| 1| 1| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 7| 1| 1| 1| 1| 7| 1| 1| 1| 1| 7| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + M + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ulcer | | 1 2.0|
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ulcer, Chronic | | 1 3.0|
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + M + + + + + + + + + + +| 47 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | 1| 1 1.0|
Fatty Change | 2 3 4 2| 12 2.6|
Focal Cellular Change | X X X X X X X X X X X X X X X X X X X X X X X | 42 |
Granuloma | | 1 2.0|
Hematopoietic Cell Proliferation, | | |
Multifocal | 1 | 1 1.0|
Hepatodiaphragmatic Nodule | X X | 5 |
Hyperplasia, Multifocal | | 1 4.0|
Infiltration Cellular, Multifocal, | | |
Lymphocyte | 2 | 1 2.0|
Inflammation, Chronic, Multifocal | 1 1 2 2 2 2 2 1 1 1 1 1 1 1| 28 1.5|
Bile Duct, Hyperplasia, Multifocal | 1 2 1 2 3 2 1 2 2 1 2 2 2 2 1 2 2 1| 27 1.8|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 9
NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| |
DAY ON TEST | 3| 3| 3| 0| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 7| 3| 3| 3| 3| 7| |
| 1| 1| 1| 1| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 7| 1| 1| 1| 1| 7| 1| 1| 1| 1| 7| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Mesentery | + + + | 6 |
Fat, Necrosis | 4 3 2 | 6 3.2|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Metaplasia, Focal | 1 | 2 1.0|
Acinus, Atrophy, Diffuse | | 2 2.5|
Acinus, Atrophy, Focal | 2 1 2 1 2 2 2 2| 10 1.6|
Acinus, Atrophy, Multifocal | 2 2 1 | 6 1.8|
Acinus, Focal Cellular Change | | 1 2.0|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + M + + + + + + + + + + + + + + M + + +| 48 |
|__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + M + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + M + + + + + + + + + + +| 49 |
Hyperplasia, Diffuse, Squamous | | 2 2.0|
Hyperplasia, Focal, Squamous | 4 | 1 4.0|
Inflammation, Acute | | 1 2.0|
Ulcer, Multiple | | 1 3.0|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + M + + + + + + + + + + +| 49 |
Erosion, Focal | 2 | 2 2.0|
|__________________________________________________________________________|____________|
Tongue | | 1 |
Abscess | | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cardiomyopathy, Multifocal | 2 1 2 1 2 2 1 1 2 2 3 2 1 2 1| 30 1.5|
Mineralization, Multifocal | | 2 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 10
NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| |
DAY ON TEST | 3| 3| 3| 0| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 7| 3| 3| 3| 3| 7| |
| 1| 1| 1| 1| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 7| 1| 1| 1| 1| 7| 1| 1| 1| 1| 7| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Focal | 1 2 1 4 1| 9 1.6|
Degeneration, Multifocal | | 1 2.0|
Fibrosis, Focal | | 1 2.0|
Hematocyst | 3 | 1 3.0|
Hematopoietic Cell Proliferation, | | |
Multifocal | 2 | 1 2.0|
Hyperplasia, Focal | 1 1 | 6 1.2|
Hyperplasia, Multifocal | 2 1 2 2 | 5 2.0|
Necrosis, Multifocal | | 1 2.0|
|__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + M + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia, Focal | 1 | 2 2.0|
Hyperplasia, Multifocal | 2 1 | 4 2.8|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Focal | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + M M + M + + + + + + + + + M + + + +| 45 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Angiectasis, Focal | 2 | 2 1.5|
Pars Distalis, Cyst | 2 2 3 2 2 | 11 2.2|
Pars Distalis, Hyperplasia, Focal | 2 2 | 5 2.2|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia, Diffuse | | 1 1.0|
C-Cell, Hyperplasia, Focal | 2 | 4 2.3|
C-Cell, Hyperplasia, Multifocal | 3 | 7 1.6|
Follicle, Cyst | | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 11
NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| |
DAY ON TEST | 3| 3| 3| 0| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 7| 3| 3| 3| 3| 7| |
| 1| 1| 1| 1| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 7| 1| 1| 1| 1| 7| 1| 1| 1| 1| 7| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + M + M + M + M + + + + + M + + + M +| 39 |
Ectasia | | 1 2.0|
Hyperplasia, Focal | 3 | 3 2.3|
Hyperplasia | | 1 2.0|
Inflammation, Acute, Focal | 1 | 1 1.0|
Inflammation, Chronic, Focal | 1 | 2 1.0|
Inflammation, Chronic, Multifocal | | 2 2.0|
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 4 2.0|
Inflammation, Chronic, Multifocal | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Dilatation | 2 2 | 3 2.3|
Cervix, Cyst | 2 | 3 2.7|
Cervix, Inflammation, Chronic | 3 | 1 3.0|
Cervix, Inflammation, Chronic Active | 4 3 | 3 3.7|
Cervix, Metaplasia, Squamous | 3 3 | 3 3.0|
Endometrium, Cyst, Multiple | 2 | 2 1.5|
Endometrium, Hyperplasia | 2 | 1 2.0|
Lumen, Hemorrhage | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Vagina | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 1 2.0|
Hyperplasia | 2 | 8 2.1|
Myelofibrosis, Multifocal | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | | 1 2.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 12
NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| |
DAY ON TEST | 3| 3| 3| 0| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 7| 3| 3| 3| 3| 7| |
| 1| 1| 1| 1| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 7| 1| 1| 1| 1| 7| 1| 1| 1| 1| 7| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + M + + + + + + + + M + + + + + M + + +| 47 |
Hyperplasia, Lymphoid | 2 | 2 2.0|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + M + + + + + + +| 46 |
Hemorrhage | | 1 2.0|
Hyperplasia, Lymphoid | 2 | 2 2.0|
Infiltration Cellular, Histiocyte | 2 2 1 | 10 1.9|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hematopoietic Cell Proliferation | 2 | 3 2.0|
Infarct | 2 | 3 1.7|
Pigmentation | | 1 2.0|
Lymphoid Follicle, Atrophy | 1 | 2 2.0|
Lymphoid Follicle, Hyperplasia, Focal| 4 | 3 3.7|
|__________________________________________________________________________|____________|
Thymus | + + + + + + M + + + + + + + M + + + + M + + + + +| 45 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + M + + + + + + + + + + + + +| 48 |
Acinus, Hyperplasia, Focal | 2 | 2 2.0|
Duct, Ectasia | 2 3 2 1 2 2 2 2 2 3 2 1 | 27 2.0|
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic | | 1 3.0|
Subcutaneous Tissue, Hemorrhage | 3 | 1 3.0|
Subcutaneous Tissue, Inflammation, | | |
Chronic Active, Focal | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperostosis | 2 3 | 4 2.5|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 13
NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| |
DAY ON TEST | 3| 3| 3| 0| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 7| 3| 3| 3| 3| 7| |
| 1| 1| 1| 1| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 7| 1| 1| 1| 1| 7| 1| 1| 1| 1| 7| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
_____________________________________________________________________________________________________________________|____________|
MUSCULOSKELETAL SYSTEM - cont | | |
Osteomalacia | | 1 2.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cerebrum, Hydrocephalus | | 1 2.0|
Cerebrum, Infiltration Cellular, | | |
Focal, Lymphocyte | 2 | 1 2.0|
Hypothalamus, Compression | 2 4 3 | 6 3.0|
|__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | | 1 2.0|
Infiltration Cellular, Multifocal, | | |
Histiocyte | 2 1 1 1 1 1 1 1 | 19 1.1|
Alveolar Epithelium, Hyperplasia, | | |
Focal | 4 | 2 3.0|
Interstitium, Inflammation, Chronic, | | |
Focal | 1 | 1 1.0|
Peribronchial, Hyperplasia, Lymphoid | 2 | 1 2.0|
Pleura, Inflammation, Chronic, Focal | | 1 1.0|
Pleura, Inflammation, Multifocal, | | |
Proliferative | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | 2 | 1 2.0|
Fungus | 4 | 2 4.0|
Mucosa, Cytoplasmic Alteration, | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 14
NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| |
DAY ON TEST | 3| 3| 3| 0| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 7| 3| 3| 3| 3| 7| |
| 1| 1| 1| 1| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 7| 1| 1| 1| 1| 7| 1| 1| 1| 1| 7| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
Multifocal | 2 1 2 1 2 1 2 1 1 1 1 1 1 1 1 2 1 1 2 1 1 1| 37 1.2|
Mucosa, Inflammation, Acute, | | |
Multifocal | 2 2 | 2 2.0|
Mucosa, Inflammation, Chronic, | | |
Multifocal | | 1 1.0|
Mucosa, Inflammation, Chronic Active,| | |
Multifocal | 3 | 1 3.0|
Mucosa, Inflammation, Multifocal, | | |
Subacute | | 2 1.5|
Mucosa, Metaplasia, Focal, Squamous | 2 | 1 2.0|
Nasolacrimal Duct, Inflammation, | | |
Chronic | 2 1 | 2 1.5|
Nasolacrimal Duct, Inflammation, | | |
Chronic Active | 2 2 | 4 2.0|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Ear | M | |
|__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lens, Cataract | 4 1 2 1 2 4 2 4 1 | 12 2.5|
Retina, Atrophy | 4 2 2 2 2 2 2 2 1 2 1 2 1 2 4 2 2 1| 25 1.9|
Sclera, Metaplasia, Focal, Osseous | 1 1 1 1 | 11 1.1|
Sclera, Metaplasia, Multifocal, | | |
Osseous | 1 1 1 1 1 | 8 1.0|
|__________________________________________________________________________|____________|
Zymbal's Gland | | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Nephropathy, Chronic, Multifocal | 1 2 1 1 3 2 1 2 2 2 2 2 1 1 2 1 1 2 2| 32 1.6|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 15
NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| |
DAY ON TEST | 3| 3| 3| 0| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 3| 7| 3| 3| 3| 3| 7| |
| 1| 1| 1| 1| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 7| 1| 1| 1| 1| 7| 1| 1| 1| 1| 7| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
_____________________________________________________________________________________________________________________|____________|
URINARY SYSTEM - cont | | |
Papilla, Necrosis | | 1 4.0|
Pelvis, Mineralization, Multifocal | | 1 1.0|
Renal Tubule, Pigmentation | 1 | 2 1.5|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Subacute | | 1 2.0|
Transitional Epithelium, Hyperplasia | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 16
NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| 6| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
20 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
LOW M/F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 3 |
Submucosa, Hemorrhage | 4 |
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + M + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fatty Change | 2 |
Focal Cellular Change | X X X X X X X X X X X X X X X X X X X X X X|
Hematopoietic Cell Proliferation, | |
Multifocal | 2 |
Hepatodiaphragmatic Nodule | X X X 1 |
Hyperplasia, Focal | 4 |
Hyperplasia, Multifocal | 3 |
Inflammation, Chronic, Multifocal | 2 2 1 3 1 2 1 2 2 2 2 3 2 2|
Bile Duct, Hyperplasia, Multifocal | 2 2 1 1 1 2 1 2 2 1 2 2 3 2 2 2 2 1 2 2|
Centrilobular, Necrosis, Acute | 3 |
|__________________________________________________________________________|
Mesentery | |
Fat, Necrosis | |
|__________________________________________________________________________|
Pancreas | + + + + M + + + + + + + + + + + + + + + + + + + +|
Necrosis, Acute, Multifocal | 4 |
__________________________________________|__________________________________________________________________________|
Page 17
NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| 6| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
20 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
LOW M/F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Acinus, Atrophy, Diffuse | 2 |
Acinus, Atrophy, Focal | 1 1 1 |
Acinus, Atrophy, Multifocal | |
|__________________________________________________________________________|
Pharynx | + |
Palate, Ulcer | 2 |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + M + + + + + + + + + + + + + + + + +|
Atrophy, Diffuse | |
|__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | |
|__________________________________________________________________________|
Tooth | |
Abscess | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | + + |
Aorta, Inflammation, Chronic, Focal | 4 |
Artery, Thrombosis | 4 |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy, Multifocal | 2 2 2 1 1 1 2 2 1 1 2 1 1|
Inflammation, Acute, Multifocal | 3 |
Atrium, Thrombosis | 3 |
Valve, Inflammation, Chronic Active | 4 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Focal | 1 2 |
__________________________________________|__________________________________________________________________________|
Page 18
NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| 6| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
20 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
LOW M/F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
Degeneration, Multifocal | 2 |
Hematocyst, Focal | 2 |
Hematocyst | 2 2 |
Hyperplasia, Focal | 1 4 2 |
Hyperplasia, Multifocal | 3 3 |
|__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + M + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 2 2 2|
Hyperplasia, Multifocal | |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + M + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + M + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis, Focal | 2 2 |
Pars Distalis, Cyst | 2 2 |
Pars Distalis, Hemorrhage | |
Pars Distalis, Hyperplasia, Focal | |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia, Focal | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + + + M M M + + + + + + + + + M M + + M M + + +|
Hyperplasia, Focal | 2 |
Inflammation, Chronic, Multifocal | 1 |
Inflammation, Chronic Active, | |
Multifocal | 2 |
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 2 X |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 19
NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| 6| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
20 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
LOW M/F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 3 |
Amyloid Deposition | 1 |
Cervix, Cyst | 2 |
Cervix, Dilatation | 3 |
Cervix, Inflammation, Acute | 2 |
Endometrium, Cyst, Multiple | 2 2 2 |
|__________________________________________________________________________|
Vagina | + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 |
Myelofibrosis, Multifocal | 1 1 |
|__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + M + + + + + + + + + + + + + + + + +|
Degeneration, Cystic, Focal | |
Pigmentation | |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 4 |
Hyperplasia, Lymphoid | |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 3 |
Hematopoietic Cell Proliferation | 2 |
Lymphoid Follicle, Atrophy | 4 |
Lymphoid Follicle, Hyperplasia, Focal| 3 |
|__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + M +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + M + + +|
Acinus, Hyperplasia, Focal | |
__________________________________________|__________________________________________________________________________|
Page 20
NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| 6| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
20 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
LOW M/F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
INTEGUMENTARY SYSTEM - cont | |
Duct, Ectasia | 2 2 2 2 2 3 3 2 2|
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 3 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cerebrum, Necrosis, Focal | 2 |
Hypothalamus, Compression | 2 3 |
|__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Multifocal, | |
Histiocyte | 1 1 1 1 1 1 1 1 1 1 1 1 1 |
Pigmentation, Multifocal | 3 |
Alveolar Epithelium, Hyperplasia, | |
Focal | 4 2 |
Interstitium, Inflammation, Chronic, | |
Diffuse | |
Pleura, Fibrosis, Focal | 3 |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | |
Fungus | 2 2 2 |
Mucosa, Cytoplasmic Alteration, | |
Multifocal | 2 1 1 1 2 1 1 1 2 1 2 1 2 2 2 1 1 1 1 2 2 1 1|
Mucosa, Inflammation, Chronic, Focal | 1 |
__________________________________________|__________________________________________________________________________|
Page 21
NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 6| 6| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
20 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
LOW M/F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
Mucosa, Inflammation, Chronic Active,| |
Multifocal | 3 2 2 |
Mucosa, Inflammation, Multifocal, | |
Subacute | |
Mucosa, Metaplasia, Focal, Squamous | 2 2 |
Nasolacrimal Duct, Inflammation, | |
Chronic | 1 1 |
Nasolacrimal Duct, Inflammation, | |
Chronic Active | 2 |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Ear | M M|
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lens, Cataract | 4 |
Retina, Atrophy | 3 1 2 |
Sclera, Metaplasia, Focal, Osseous | 1 1 1 1|
Sclera, Metaplasia, Multifocal, | |
Osseous | 1 1 2 1 1 2 2 1 2 |
|__________________________________________________________________________|
Harderian Gland | |
Inflammation, Acute | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bacterium | X |
Cyst | 2 |
Inflammation, Acute, Multifocal | 4 |
Nephropathy, Chronic, Multifocal | 2 1 2 3 1 1 1 1|
Pelvis, Mineralization, Multifocal | 1 |
Renal Tubule, Pigmentation | |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________
Page 22
NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 3| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| |
DAY ON TEST | 3| 3| 3| 3| 7| 3| 3| 4| 3| 3| 3| 3| 3| 6| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| |
| 3| 3| 3| 3| 8| 2| 2| 0| 2| 2| 2| 2| 2| 9| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
20 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
LOW M/F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + M + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + M| 49 |
Inflammation, Acute | | 1 3.0|
Submucosa, Hemorrhage | | 1 4.0|
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fatty Change | 4 4 3| 4 3.3|
Focal Cellular Change | X X X X X X X X X X X X X X X X X X X X | 42 |
Hematopoietic Cell Proliferation, | | |
Multifocal | | 1 2.0|
Hepatodiaphragmatic Nodule | X X X X X | 9 1.0|
Hyperplasia, Focal | 3 | 2 3.5|
Hyperplasia, Multifocal | 2 | 2 2.5|
Inflammation, Chronic, Multifocal | 2 2 1 2 3 2 2 2 1 1 1 | 25 1.8|
Bile Duct, Hyperplasia, Multifocal | 2 2 1 2 2 2 2 2 2 3 1 2 1 2 1 3| 36 1.8|
Centrilobular, Necrosis, Acute | | 1 3.0|
|__________________________________________________________________________|____________|
Mesentery | + | 1 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 23
NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 3| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| |
DAY ON TEST | 3| 3| 3| 3| 7| 3| 3| 4| 3| 3| 3| 3| 3| 6| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| |
| 3| 3| 3| 3| 8| 2| 2| 0| 2| 2| 2| 2| 2| 9| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
20 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
LOW M/F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Fat, Necrosis | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Necrosis, Acute, Multifocal | | 1 4.0|
Acinus, Atrophy, Diffuse | | 1 2.0|
Acinus, Atrophy, Focal | 1 2 | 5 1.2|
Acinus, Atrophy, Multifocal | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Pharynx | | 1 |
Palate, Ulcer | | 1 2.0|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Atrophy, Diffuse | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ulcer | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Tooth | + | 1 |
Abscess | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | | 2 |
Aorta, Inflammation, Chronic, Focal | | 1 4.0|
Artery, Thrombosis | | 1 4.0|
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy, Multifocal | 3 2 2 1 1 2 2 1 1 1 2 1 2 1 | 27 1.5|
Inflammation, Acute, Multifocal | | 1 3.0|
Atrium, Thrombosis | | 1 3.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 24
NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 3| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| |
DAY ON TEST | 3| 3| 3| 3| 7| 3| 3| 4| 3| 3| 3| 3| 3| 6| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| |
| 3| 3| 3| 3| 8| 2| 2| 0| 2| 2| 2| 2| 2| 9| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
20 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
LOW M/F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
_____________________________________________________________________________________________________________________|____________|
CARDIOVASCULAR SYSTEM - cont | | |
Valve, Inflammation, Chronic Active | | 1 4.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + M + + + + + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + M + + + + + + + + + + + +| 48 |
Degeneration, Focal | 2 2 2 3 | 6 2.0|
Degeneration, Multifocal | 2 2 | 3 2.0|
Hematocyst, Focal | | 1 2.0|
Hematocyst | 2 2 | 4 2.0|
Hyperplasia, Focal | 2 2 2 1 | 7 2.0|
Hyperplasia, Multifocal | 2 | 3 2.7|
|__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + M + + + + + + + + + + + +| 47 |
Hyperplasia, Focal | 1 2 1 4 | 8 2.0|
Hyperplasia, Multifocal | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + M +| 48 |
Hyperplasia, Focal | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + M M M + + + + M + M + + + + + + M| 44 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + M + + + + + + + + + + + + +| 48 |
Pars Distalis, Angiectasis, Focal | 2 | 3 2.0|
Pars Distalis, Cyst | 2 2| 4 2.0|
Pars Distalis, Hemorrhage | 2 | 1 2.0|
Pars Distalis, Hyperplasia, Focal | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia, Focal | 2 3 2 | 4 2.3|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 25
NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 3| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| |
DAY ON TEST | 3| 3| 3| 3| 7| 3| 3| 4| 3| 3| 3| 3| 3| 6| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| |
| 3| 3| 3| 3| 8| 2| 2| 0| 2| 2| 2| 2| 2| 9| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
20 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
LOW M/F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + + + + + M + M M + + + + + + + M + M + M + +| 37 |
Hyperplasia, Focal | 3 | 2 2.5|
Inflammation, Chronic, Multifocal | 1 | 2 1.0|
Inflammation, Chronic Active, | | |
Multifocal | 1 3 | 3 2.0|
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | X | 4 2.0|
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Abscess | | 1 3.0|
Amyloid Deposition | | 1 1.0|
Cervix, Cyst | | 1 2.0|
Cervix, Dilatation | 3 | 2 3.0|
Cervix, Inflammation, Acute | | 1 2.0|
Endometrium, Cyst, Multiple | 1 | 4 1.8|
|__________________________________________________________________________|____________|
Vagina | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | | 2 2.0|
Myelofibrosis, Multifocal | | 2 1.0|
|__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Degeneration, Cystic, Focal | 1 | 1 1.0|
Pigmentation | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + M + + + + + + + + + + + + + +| 49 |
Congestion | | 1 4.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 26
NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 3| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| |
DAY ON TEST | 3| 3| 3| 3| 7| 3| 3| 4| 3| 3| 3| 3| 3| 6| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| |
| 3| 3| 3| 3| 8| 2| 2| 0| 2| 2| 2| 2| 2| 9| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
20 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
LOW M/F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Hyperplasia, Lymphoid | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | | 1 3.0|
Hematopoietic Cell Proliferation | 2 | 2 2.0|
Lymphoid Follicle, Atrophy | | 1 4.0|
Lymphoid Follicle, Hyperplasia, Focal| | 1 3.0|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + M + + + + M + + + + + + + + +| 47 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Acinus, Hyperplasia, Focal | 4 | 1 4.0|
Duct, Ectasia | 2 2 2 2 2 3 3 4 3 4 2| 20 2.5|
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ulcer | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperostosis | 3 3 | 4 3.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cerebrum, Necrosis, Focal | | 1 2.0|
Hypothalamus, Compression | 4 2 4 2 3 | 7 2.9|
|__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + M + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 27
NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 3| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| |
DAY ON TEST | 3| 3| 3| 3| 7| 3| 3| 4| 3| 3| 3| 3| 3| 6| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| |
| 3| 3| 3| 3| 8| 2| 2| 0| 2| 2| 2| 2| 2| 9| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
20 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
LOW M/F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Multifocal, | | |
Histiocyte | 1 1 1 1 1 1 1 1 1| 22 1.0|
Pigmentation, Multifocal | | 1 3.0|
Alveolar Epithelium, Hyperplasia, | | |
Focal | 4 | 3 3.3|
Interstitium, Inflammation, Chronic, | | |
Diffuse | 2 | 1 2.0|
Pleura, Fibrosis, Focal | | 1 3.0|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | 2 | 1 2.0|
Fungus | | 3 2.0|
Mucosa, Cytoplasmic Alteration, | | |
Multifocal | 1 1 2 1 1 1 2 2 2 2 1 2 1 1 1 1 | 39 1.4|
Mucosa, Inflammation, Chronic, Focal | | 1 1.0|
Mucosa, Inflammation, Chronic Active,| | |
Multifocal | 2 | 4 2.3|
Mucosa, Inflammation, Multifocal, | | |
Subacute | 2 2 1 | 3 1.7|
Mucosa, Metaplasia, Focal, Squamous | | 2 2.0|
Nasolacrimal Duct, Inflammation, | | |
Chronic | 2 1 | 4 1.3|
Nasolacrimal Duct, Inflammation, | | |
Chronic Active | | 1 2.0|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Ear | M | |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 28
NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 3| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| |
DAY ON TEST | 3| 3| 3| 3| 7| 3| 3| 4| 3| 3| 3| 3| 3| 6| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 9| |
| 3| 3| 3| 3| 8| 2| 2| 0| 2| 2| 2| 2| 2| 9| 4| 2| 2| 2| 2| 2| 2| 2| 2| 2| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
20 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
LOW M/F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
_____________________________________________________________________________________________________________________|____________|
SPECIAL SENSES SYSTEM - cont | | |
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lens, Cataract | 2 2 2 4 2 1 | 7 2.4|
Retina, Atrophy | 3 3 3 1 2 2 3 2 3 2 3 3 2 2 | 17 2.4|
Sclera, Metaplasia, Focal, Osseous | 1 1 1 1 1 1 | 10 1.0|
Sclera, Metaplasia, Multifocal, | | |
Osseous | 1 2 2 1 1 2 | 15 1.5|
|__________________________________________________________________________|____________|
Harderian Gland | + + | 2 |
Inflammation, Acute | 4 | 1 4.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Bacterium | | 1 |
Cyst | | 1 2.0|
Inflammation, Acute, Multifocal | | 1 4.0|
Nephropathy, Chronic, Multifocal | 2 2 3 2 2 3 2 1 1 1 | 18 1.7|
Pelvis, Mineralization, Multifocal | 2 | 2 1.5|
Renal Tubule, Pigmentation | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + M + + + + + M + + + + +| 48 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 29
NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 2| 7| 7| 7| 7| 7| 7| 5|
DAY ON TEST | 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 6| 0| 3| 3| 2| 2| 1| 3| 3| 3| 3| 3|
| 1| 1| 1| 1| 1| 3| 1| 1| 1| 1| 2| 2| 2| 9| 4| 2| 2| 0| 4| 0| 2| 2| 2| 2| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
100 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
HIGH M/F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + A + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fatty Change | 2 |
Focal Cellular Change | X X X X X X X X X X X X X X X X X X |
Hematopoietic Cell Proliferation, | |
Multifocal | |
Hepatodiaphragmatic Nodule | X X X X |
Hyperplasia, Focal | 2 |
Hyperplasia, Multifocal | 3 |
Inflammation, Chronic, Multifocal | 2 2 1 1 2 |
Inflammation, Focal, Granulomatous | 4 |
Necrosis, Multifocal | 3 |
Bile Duct, Hyperplasia, Focal | 1 |
Bile Duct, Hyperplasia, Multifocal | 2 1 2 2 2 2 3 2 1 2 2 2 2 2 2 1 2 2|
Vein, Thrombosis | 4 |
|__________________________________________________________________________|
Mesentery | + |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + A + + + + + +|
Acinus, Atrophy, Focal | 1 2 1 |
__________________________________________|__________________________________________________________________________|
Page 30
NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 2| 7| 7| 7| 7| 7| 7| 5|
DAY ON TEST | 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 6| 0| 3| 3| 2| 2| 1| 3| 3| 3| 3| 3|
| 1| 1| 1| 1| 1| 3| 1| 1| 1| 1| 2| 2| 2| 9| 4| 2| 2| 0| 4| 0| 2| 2| 2| 2| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
100 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
HIGH M/F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Acinus, Atrophy, Multifocal | 1 2 2 2 1 2|
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion, Focal | |
Hyperplasia, Diffuse, Squamous | 2|
Inflammation, Chronic Active | 4|
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 3|
|__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy, Multifocal | 1 2 1 2 2 2 2 3 1 2 1 |
Atrium, Thrombosis | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Focal | 2 1 2 |
Hematocyst | 2 |
Hyperplasia, Focal | 3 |
Hyperplasia, Multifocal | 2 |
|__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 1 |
Hyperplasia, Multifocal | 3 |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 31
NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 2| 7| 7| 7| 7| 7| 7| 5|
DAY ON TEST | 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 6| 0| 3| 3| 2| 2| 1| 3| 3| 3| 3| 3|
| 1| 1| 1| 1| 1| 3| 1| 1| 1| 1| 2| 2| 2| 9| 4| 2| 2| 0| 4| 0| 2| 2| 2| 2| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
100 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
HIGH M/F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Angiectasis, Focal | |
Pars Distalis, Cyst | X X |
Pars Distalis, Fibrosis | 4|
Pars Distalis, Hyperplasia, Focal | 2 |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia, Focal | |
C-Cell, Hyperplasia, Multifocal | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Clitoral Gland | + + M + M + + M + M + M + + + + + M M + + + + + +|
Inflammation, Chronic, Focal | |
|__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | X |
|__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | |
Endometrium, Cyst | 2 X X|
Endometrium, Cyst, Multiple | X X X 1 1 |
Endometrium, Inflammation, Focal, | |
Subacute | 1 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Blood | + |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + A + + + + + +|
Atrophy | 3 |
Hyperplasia | |
Myelofibrosis, Focal | 2 |
__________________________________________|__________________________________________________________________________|
Page 32
NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 2| 7| 7| 7| 7| 7| 7| 5|
DAY ON TEST | 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 6| 0| 3| 3| 2| 2| 1| 3| 3| 3| 3| 3|
| 1| 1| 1| 1| 1| 3| 1| 1| 1| 1| 2| 2| 2| 9| 4| 2| 2| 0| 4| 0| 2| 2| 2| 2| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
100 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
HIGH M/F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
Myelofibrosis, Multifocal | 2 1 2 1 |
|__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Pigmentation | |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 2 |
Infiltration Cellular, Histiocyte | 2 2 |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + A + + + + + +|
Infarct | 4 |
|__________________________________________________________________________|
Thymus | + + + + + + + + M + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Hyperplasia, Focal | 2 |
Duct, Ectasia | 3 |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 2 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cerebrum, Hydrocephalus | |
Hypothalamus, Compression | |
|__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 33
NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 2| 7| 7| 7| 7| 7| 7| 5|
DAY ON TEST | 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 6| 0| 3| 3| 2| 2| 1| 3| 3| 3| 3| 3|
| 1| 1| 1| 1| 1| 3| 1| 1| 1| 1| 2| 2| 2| 9| 4| 2| 2| 0| 4| 0| 2| 2| 2| 2| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
100 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
HIGH M/F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | |
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Infiltration Cellular, Multifocal, | |
Histiocyte | 1 1 1 1 1 1 1 1 1 1 1 |
Pigmentation, Multifocal | 3 |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | |
Mucosa, Cytoplasmic Alteration, | |
Multifocal | 2 1 2 2 1 2 2 1 2 2 1 2 1 1 2 2 2 1 2 2|
Mucosa, Inflammation, Acute, | |
Multifocal | |
Mucosa, Inflammation, Chronic Active,| |
Focal | 1 |
Mucosa, Metaplasia, Focal, Squamous | |
Nasolacrimal Duct, Inflammation, | |
Chronic | 2 |
Nasolacrimal Duct, Inflammation, | |
Chronic Active | |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Ear | + |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lens, Cataract | 2 2 2 2 2 2 2 2 1 2 2 2 2 |
Retina, Atrophy | 3 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1|
Sclera, Metaplasia, Focal, Osseous | 1 1 1 1 1 1 1 |
Sclera, Metaplasia, Multifocal, | |
Osseous | 1 2 |
|__________________________________________________________________________|
Harderian Gland | + + |
Infiltration Cellular, Multifocal, | |
__________________________________________|__________________________________________________________________________|
Page 34
NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 2| 7| 7| 7| 7| 7| 7| 5|
DAY ON TEST | 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 6| 0| 3| 3| 2| 2| 1| 3| 3| 3| 3| 3|
| 1| 1| 1| 1| 1| 3| 1| 1| 1| 1| 2| 2| 2| 9| 4| 2| 2| 0| 4| 0| 2| 2| 2| 2| 5|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
100 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
HIGH M/F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
Lymphocyte | 2 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bacterium | X |
Cyst | |
Inflammation, Acute, Multifocal | 3 |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Calculus Gross Observation | X |
Inflammation, Chronic | 2 |
Transitional Epithelium, Hyperplasia | 3 |
__________________________________________|__________________________________________________________________________
Page 35
NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 4| 7| 7| 7| 6| 7| 7| 7| 6| 6| |
DAY ON TEST | 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 5| 3| 3| 3| 9| 3| 3| 3| 9| 7| |
| 2| 2| 2| 2| 4| 2| 1| 2| 2| 2| 2| 2| 2| 2| 6| 3| 2| 2| 2| 4| 2| 2| 2| 6| 6| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
100 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
HIGH M/F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fatty Change | 1 | 2 1.5|
Focal Cellular Change | X X X X X X X X X X X X X X X X X X X X X X X| 41 |
Hematopoietic Cell Proliferation, | | |
Multifocal | 2 | 1 2.0|
Hepatodiaphragmatic Nodule | X X X X X| 9 |
Hyperplasia, Focal | | 1 2.0|
Hyperplasia, Multifocal | | 1 3.0|
Inflammation, Chronic, Multifocal | 2 2 1 1 1 1 2 1 1 2 1 2 1 2 | 19 1.5|
Inflammation, Focal, Granulomatous | | 1 4.0|
Necrosis, Multifocal | | 1 3.0|
Bile Duct, Hyperplasia, Focal | | 1 1.0|
Bile Duct, Hyperplasia, Multifocal | 1 1 2 1 2 2 1 1 1 2 2 3| 30 1.8|
Vein, Thrombosis | | 1 4.0|
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 36
NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 4| 7| 7| 7| 6| 7| 7| 7| 6| 6| |
DAY ON TEST | 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 5| 3| 3| 3| 9| 3| 3| 3| 9| 7| |
| 2| 2| 2| 2| 4| 2| 1| 2| 2| 2| 2| 2| 2| 2| 6| 3| 2| 2| 2| 4| 2| 2| 2| 6| 6| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
100 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
HIGH M/F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Mesentery | | 1 |
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Acinus, Atrophy, Focal | 1 1 1 1 1 2 | 9 1.2|
Acinus, Atrophy, Multifocal | 2 2 1 | 9 1.7|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + M + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Erosion, Focal | 2 | 1 2.0|
Hyperplasia, Diffuse, Squamous | | 1 2.0|
Inflammation, Chronic Active | | 1 4.0|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ulcer | | 1 3.0|
|__________________________________________________________________________|____________|
Tooth | + | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy, Multifocal | 2 1 2 2 1 2 1 1 1 2 1 1 1 1 2 2 1 | 28 1.5|
Atrium, Thrombosis | | 1 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Focal | | 3 1.7|
Hematocyst | 2 2 2 | 4 2.0|
Hyperplasia, Focal | 1 2 2 2 2 | 6 2.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 37
NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 4| 7| 7| 7| 6| 7| 7| 7| 6| 6| |
DAY ON TEST | 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 5| 3| 3| 3| 9| 3| 3| 3| 9| 7| |
| 2| 2| 2| 2| 4| 2| 1| 2| 2| 2| 2| 2| 2| 2| 6| 3| 2| 2| 2| 4| 2| 2| 2| 6| 6| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
100 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
HIGH M/F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
Hyperplasia, Multifocal | | 1 2.0|
|__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + M + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia, Focal | 2 | 3 1.7|
Hyperplasia, Multifocal | | 1 3.0|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + M + + + + + + M + + + + + + + + + + + + M| 47 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Pars Distalis, Angiectasis, Focal | 2 | 1 2.0|
Pars Distalis, Cyst | X X 2 X X 2 | 8 2.0|
Pars Distalis, Fibrosis | | 1 4.0|
Pars Distalis, Hyperplasia, Focal | 3 1 1 | 4 1.8|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia, Focal | 4 2 3 | 3 3.0|
C-Cell, Hyperplasia, Multifocal | | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Clitoral Gland | + + + M M + + + + + + M M + + + + + + + + + + + +| 39 |
Inflammation, Chronic, Focal | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 1 |
|__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Dilatation | 2 2 3 2 | 4 2.3|
Endometrium, Cyst | 2 | 4 2.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 38
NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 4| 7| 7| 7| 6| 7| 7| 7| 6| 6| |
DAY ON TEST | 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 5| 3| 3| 3| 9| 3| 3| 3| 9| 7| |
| 2| 2| 2| 2| 4| 2| 1| 2| 2| 2| 2| 2| 2| 2| 6| 3| 2| 2| 2| 4| 2| 2| 2| 6| 6| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
100 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
HIGH M/F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
Endometrium, Cyst, Multiple | 2 X 1 X X X| 11 1.3|
Endometrium, Inflammation, Focal, | | |
Subacute | | 1 1.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Blood | | 1 |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Atrophy | | 1 3.0|
Hyperplasia | 2 | 1 2.0|
Myelofibrosis, Focal | | 1 2.0|
Myelofibrosis, Multifocal | 4 1 1 1 1 2 | 10 1.6|
|__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mediastinal, Pigmentation | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + M + + + + + + + + + + + + + + + + +| 48 |
Congestion | | 1 2.0|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + M + + + + + + + + + + + + + + + + + + + + +| 49 |
Congestion | 1 1 1 | 4 1.3|
Infiltration Cellular, Histiocyte | 1 | 3 1.7|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Infarct | 2 | 2 3.0|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + + M + + + + + + + M + + + + + + + +| 47 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + M + + + M + + + M + + + + + + + + + + + +| 47 |
Acinus, Hyperplasia, Focal | | 1 2.0|
Duct, Ectasia | 2 2 2 2 | 5 2.2|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 39
NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 4| 7| 7| 7| 6| 7| 7| 7| 6| 6| |
DAY ON TEST | 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 5| 3| 3| 3| 9| 3| 3| 3| 9| 7| |
| 2| 2| 2| 2| 4| 2| 1| 2| 2| 2| 2| 2| 2| 2| 6| 3| 2| 2| 2| 4| 2| 2| 2| 6| 6| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
100 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
HIGH M/F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
_____________________________________________________________________________________________________________________|____________|
INTEGUMENTARY SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | 3 3 | 2 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperostosis | 4 2 4 2 | 6 2.7|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cerebrum, Hydrocephalus | 2 | 1 2.0|
Hypothalamus, Compression | 2 2 | 2 2.0|
|__________________________________________________________________________|____________|
Spinal Cord | + + M + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic, Focal | 1 | 1 1.0|
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Infiltration Cellular, Multifocal, | | |
Histiocyte | 1 1 1 1 1 1 1 1 1| 20 1.0|
Pigmentation, Multifocal | | 1 3.0|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fungus | 3 | 1 3.0|
Mucosa, Cytoplasmic Alteration, | | |
Multifocal | 1 1 2 1 2 1 2 1 2 1 2 2 2 1| 34 1.6|
Mucosa, Inflammation, Acute, | | |
Multifocal | 3 2 | 2 2.5|
Mucosa, Inflammation, Chronic Active,| | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 40
NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 4| 7| 7| 7| 6| 7| 7| 7| 6| 6| |
DAY ON TEST | 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 5| 3| 3| 3| 9| 3| 3| 3| 9| 7| |
| 2| 2| 2| 2| 4| 2| 1| 2| 2| 2| 2| 2| 2| 2| 6| 3| 2| 2| 2| 4| 2| 2| 2| 6| 6| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
100 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
HIGH M/F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
Focal | | 1 1.0|
Mucosa, Metaplasia, Focal, Squamous | 2 | 1 2.0|
Nasolacrimal Duct, Inflammation, | | |
Chronic | 2 | 2 2.0|
Nasolacrimal Duct, Inflammation, | | |
Chronic Active | 2 2 2 | 3 2.0|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Ear | | 1 |
|__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lens, Cataract | 2 2 2 1 3 4 2 2 2 2 2 2 3 2 1 1 1 2 2 1 3 3 1| 37 2.0|
Retina, Atrophy | 2 2 3 2 2 3 3 3 3 2 2 2 2 2 3 2 2 2 3 2 2 2 2| 42 2.2|
Sclera, Metaplasia, Focal, Osseous | 1 1 1 1 2 | 12 1.1|
Sclera, Metaplasia, Multifocal, | | |
Osseous | 1 1 1 | 5 1.2|
|__________________________________________________________________________|____________|
Harderian Gland | | 2 |
Infiltration Cellular, Multifocal, | | |
Lymphocyte | | 1 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Bacterium | | 1 |
Cyst | 2 | 1 2.0|
Inflammation, Acute, Multifocal | | 1 3.0|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Calculus Gross Observation | | 1 |
Inflammation, Chronic | | 1 2.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 41
NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 4| 7| 7| 7| 6| 7| 7| 7| 6| 6| |
DAY ON TEST | 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 5| 3| 3| 3| 9| 3| 3| 3| 9| 7| |
| 2| 2| 2| 2| 4| 2| 1| 2| 2| 2| 2| 2| 2| 2| 6| 3| 2| 2| 2| 4| 2| 2| 2| 6| 6| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
100 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
HIGH M/F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
_____________________________________________________________________________________________________________________|____________|
URINARY SYSTEM - cont | | |
Transitional Epithelium, Hyperplasia | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 42
NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 3| 7| 6| 7| 6| 7| 6| 7| 5| 5| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6|
DAY ON TEST | 2| 2| 2| 0| 7| 1| 2| 9| 2| 8| 2| 3| 2| 5| 3| 2| 2| 2| 9| 3| 2| 2| 2| 5| 3|
| 9| 9| 9| 8| 6| 6| 9| 1| 2| 4| 9| 7| 9| 8| 3| 9| 9| 9| 5| 8| 9| 9| 9| 9| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Subacute | 3 |
|__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + M + + + + + M + + + + + + +|
|__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + A + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + A + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Multifocal | |
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + A + + + + + + + + + + + + + + + + +|
Inflammation, Chronic, Focal | |
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic, Focal | 1 |
Degeneration, Cystic, Multifocal | 3 |
Fatty Change | 2 1 3 |
Focal Cellular Change | X X X X X X X X X X |
Hematopoietic Cell Proliferation, | |
Multifocal | 2 2 |
Hepatodiaphragmatic Nodule | X X X X X |
Hyperplasia, Focal | 2 2 |
Inflammation, Chronic, Multifocal | 1 2 |
Bile Duct, Hyperplasia, Multifocal | 3 2 2 2 3 2 3 3 3 3 2 1 2 2 2 1 3 1 2 2 3 3 2|
Centrilobular, Necrosis, Acute | 3 |
|__________________________________________________________________________|
Mesentery | + + + + |
Inflammation, Chronic, Multifocal | 2 |
Fat, Necrosis | 4 4 4 |
__________________________________________|__________________________________________________________________________|
Page 43
NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 3| 7| 6| 7| 6| 7| 6| 7| 5| 5| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6|
DAY ON TEST | 2| 2| 2| 0| 7| 1| 2| 9| 2| 8| 2| 3| 2| 5| 3| 2| 2| 2| 9| 3| 2| 2| 2| 5| 3|
| 9| 9| 9| 8| 6| 6| 9| 1| 2| 4| 9| 7| 9| 8| 3| 9| 9| 9| 5| 8| 9| 9| 9| 9| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + A + + + + + + + + + + + + +|
Acinus, Atrophy, Diffuse | 3 |
Acinus, Atrophy, Focal | 1 2 2 1 2 2 2 1 1 2 |
Acinus, Atrophy, Multifocal | 3 3 2 |
Acinus, Focal Cellular Change | X |
Acinus, Hyperplasia, Focal | 4 |
Artery, Inflammation, Chronic | 2 |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Focal | |
Inflammation, Chronic | |
|__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + M + + + + + + + + + + + + + +|
Hyperplasia, Multifocal, Squamous | 2 |
Hyperplasia, Squamous | 2 |
Inflammation, Acute | 1 |
Ulcer | 2 |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | 3 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy, Multifocal | 2 2 2 3 2 1 2 2 2 2 2 1 3 2 2 2 2 2 1 2 |
Atrium, Thrombosis | X |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + M + + + +|
|__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + M + + + +|
Degeneration, Focal | 1 1 2 |
Hematopoietic Cell Proliferation, | |
Multifocal | |
__________________________________________|__________________________________________________________________________|
Page 44
NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 3| 7| 6| 7| 6| 7| 6| 7| 5| 5| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6|
DAY ON TEST | 2| 2| 2| 0| 7| 1| 2| 9| 2| 8| 2| 3| 2| 5| 3| 2| 2| 2| 9| 3| 2| 2| 2| 5| 3|
| 9| 9| 9| 8| 6| 6| 9| 1| 2| 4| 9| 7| 9| 8| 3| 9| 9| 9| 5| 8| 9| 9| 9| 9| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
Hemorrhage | 4 |
Hyperplasia, Focal | 1 |
Hyperplasia, Multifocal | 2 |
|__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + M + + + +|
Hemorrhage | 4 |
Hyperplasia, Focal | 1 1 4 1 |
Hyperplasia, Multifocal | 4 3 |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | |
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + + M + + + + + + + M + + M M|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Pars Distalis, Abscess | |
Pars Distalis, Cyst | |
Pars Distalis, Hemorrhage | 2 |
Pars Distalis, Hyperplasia, Focal | 1 2 1 4|
Pars Intermedia, Cyst | |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia, Focal | 2 |
C-Cell, Hyperplasia, Multifocal | 3 3 2 |
Follicle, Cyst | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Preputial Gland | + + + M + M + + + + + + + + + + + + + + + + + + +|
Abscess | 3 |
Inflammation, Acute, Focal | 2|
Inflammation, Acute, Multifocal | 2 |
Inflammation, Chronic, Focal | |
__________________________________________|__________________________________________________________________________|
Page 45
NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 3| 7| 6| 7| 6| 7| 6| 7| 5| 5| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6|
DAY ON TEST | 2| 2| 2| 0| 7| 1| 2| 9| 2| 8| 2| 3| 2| 5| 3| 2| 2| 2| 9| 3| 2| 2| 2| 5| 3|
| 9| 9| 9| 8| 6| 6| 9| 1| 2| 4| 9| 7| 9| 8| 3| 9| 9| 9| 5| 8| 9| 9| 9| 9| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
Inflammation, Chronic, Multifocal | 2 1 2 1 2 2 2 1 |
Inflammation, Chronic Active, Focal | |
Inflammation, Chronic Active, | |
Multifocal | |
Inflammation, Multifocal, Subacute | |
|__________________________________________________________________________|
Prostate | + + + + + + + + M + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 1 2 |
Inflammation, Acute, Focal | |
Inflammation, Chronic, Focal | 2 |
Inflammation, Chronic, Multifocal | |
Inflammation, Chronic Active, | |
Multifocal | 3 |
|__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + M + + + + + + + + + + + + + + + +|
Atrophy, Diffuse | 3 1 3 4 2 4 4 3 3 4 2 4 3 3 |
Dilatation | 2 |
Inflammation, Chronic, Multifocal | 2 |
|__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Diffuse | 3 2 |
Atrophy, Focal | |
Atrophy | 2 |
Granuloma Sperm | |
Interstitial Cell, Hyperplasia, | |
Multifocal | 2 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Blood | + |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 |
Infiltration Cellular, Focal, | |
Histiocyte | 2 |
|__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 46
NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 3| 7| 6| 7| 6| 7| 6| 7| 5| 5| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6|
DAY ON TEST | 2| 2| 2| 0| 7| 1| 2| 9| 2| 8| 2| 3| 2| 5| 3| 2| 2| 2| 9| 3| 2| 2| 2| 5| 3|
| 9| 9| 9| 8| 6| 6| 9| 1| 2| 4| 9| 7| 9| 8| 3| 9| 9| 9| 5| 8| 9| 9| 9| 9| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | 2 |
Hyperplasia, Plasma Cell | 1 |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + M + + + + + + + +|
Congestion | 2 |
Degeneration, Cystic | 3 |
Hyperplasia, Lymphoid | |
Infiltration Cellular, Histiocyte | 2 |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Focal | 2 |
Fibrosis, Diffuse | 2 |
Fibrosis, Focal | 4 |
Hematopoietic Cell Proliferation | 2 2 |
Lymphoid Follicle, Atrophy | |
|__________________________________________________________________________|
Thymus | M + M M + + + + + + + + M + + M + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | M + M + + M + + M + + M + + + + + + + + + + + + +|
Inflammation, Chronic | |
Acinus, Hyperplasia, Focal | 3 |
Duct, Ectasia | 2 2 3 2 2 |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst Epithelial Inclusion | |
Inflammation, Acute, Focal | 1 |
Inflammation, Chronic, Focal | |
Subcutaneous Tissue, Fibrosis, Focal | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 2 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
__________________________________________|__________________________________________________________________________|
Page 47
NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 3| 7| 6| 7| 6| 7| 6| 7| 5| 5| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6|
DAY ON TEST | 2| 2| 2| 0| 7| 1| 2| 9| 2| 8| 2| 3| 2| 5| 3| 2| 2| 2| 9| 3| 2| 2| 2| 5| 3|
| 9| 9| 9| 8| 6| 6| 9| 1| 2| 4| 9| 7| 9| 8| 3| 9| 9| 9| 5| 8| 9| 9| 9| 9| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
NERVOUS SYSTEM - cont | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hydrocephalus | 2 |
Cerebellum, Necrosis, Focal | |
Hypothalamus, Compression | 3 2 2 |
|__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Larynx | + + + + + + + + + + + + M + + + + + + + + + + + +|
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis, Focal | |
Foreign Body | 2 |
Infiltration Cellular, Multifocal, | |
Histiocyte | 1 1 |
Inflammation, Acute, Multifocal | 3 |
Inflammation, Granulomatous, | |
Multifocal | |
Alveolar Epithelium, Hyperplasia, | |
Focal | 4 3 |
Interstitium, Inflammation, Chronic, | |
Multifocal | 2 2 |
Peribronchiolar, Hyperplasia, | |
Lymphoid | |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | |
Fungus | 2 2 2|
Mucosa, Cytoplasmic Alteration, | |
Multifocal | |
Mucosa, Foreign Body, Focal | |
Mucosa, Inflammation, Acute, Focal | 3|
Mucosa, Inflammation, Acute, | |
Multifocal | 2 1 |
Mucosa, Inflammation, Chronic, | |
__________________________________________|__________________________________________________________________________|
Page 48
NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 3| 7| 6| 7| 6| 7| 6| 7| 5| 5| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6|
DAY ON TEST | 2| 2| 2| 0| 7| 1| 2| 9| 2| 8| 2| 3| 2| 5| 3| 2| 2| 2| 9| 3| 2| 2| 2| 5| 3|
| 9| 9| 9| 8| 6| 6| 9| 1| 2| 4| 9| 7| 9| 8| 3| 9| 9| 9| 5| 8| 9| 9| 9| 9| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
Multifocal | |
Mucosa, Inflammation, Chronic Active,| |
Multifocal | 2 |
Mucosa, Inflammation, Focal, Subacute| |
Mucosa, Inflammation, Multifocal, | |
Subacute | 2 |
Mucosa, Metaplasia, Multifocal, | |
Squamous | 2 |
Nasolacrimal Duct, Inflammation, | |
Chronic | 2 1 1 |
Nasolacrimal Duct, Inflammation, | |
Chronic Active | 2 2 |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lens, Cataract | 3 2|
Retina, Atrophy | 2 2|
Sclera, Metaplasia, Focal, Osseous | 1 1 1 1 2 2 1 1 1|
Sclera, Metaplasia, Multifocal, | |
Osseous | 2 2 3 1 1 2 2 2 2 3 2 2 2 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
Nephropathy, Chronic, Multifocal | 3 3 3 2 1 2 2 3 2 3 2 3 2 1 2 3 2 2 3 3 3 2 2 2|
Renal Tubule, Pigmentation | 2 |
Transitional Epithelium, Hyperplasia | |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
Dilatation | 4 |
__________________________________________|__________________________________________________________________________
Page 49
NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 6| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| |
DAY ON TEST | 2| 2| 6| 2| 1| 2| 2| 8| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 7| |
| 9| 9| 4| 9| 7| 9| 9| 4| 5| 2| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 6| 9| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Subacute | | 1 3.0|
|__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Chronic, Multifocal | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Chronic, Focal | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Cystic, Focal | 2 2 1 | 4 1.5|
Degeneration, Cystic, Multifocal | | 1 3.0|
Fatty Change | 2 2 | 5 2.0|
Focal Cellular Change | X X X X X X X X X X X X X X X X X X X | 29 |
Hematopoietic Cell Proliferation, | | |
Multifocal | | 2 2.0|
Hepatodiaphragmatic Nodule | X | 6 |
Hyperplasia, Focal | 2 | 3 2.0|
Inflammation, Chronic, Multifocal | 2 1 1 2 1 | 7 1.4|
Bile Duct, Hyperplasia, Multifocal | 1 2 2 2 2 2 2 3 1 2 2 2 2 2 2 2 2 2 2 2 1 2 2| 46 2.1|
Centrilobular, Necrosis, Acute | | 1 3.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 50
NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 6| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| |
DAY ON TEST | 2| 2| 6| 2| 1| 2| 2| 8| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 7| |
| 9| 9| 4| 9| 7| 9| 9| 4| 5| 2| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 6| 9| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Mesentery | + + | 6 |
Inflammation, Chronic, Multifocal | | 1 2.0|
Fat, Necrosis | 2 | 4 3.5|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Acinus, Atrophy, Diffuse | | 1 3.0|
Acinus, Atrophy, Focal | 3 2 2 2 | 14 1.8|
Acinus, Atrophy, Multifocal | 2 2 2 2 2 1 2 2 | 11 2.1|
Acinus, Focal Cellular Change | | 1 |
Acinus, Hyperplasia, Focal | | 1 4.0|
Artery, Inflammation, Chronic | | 1 2.0|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage, Focal | 2 | 1 2.0|
Inflammation, Chronic | 4 | 1 4.0|
|__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + M + + + + + + + + + + + + + + + + +| 48 |
Hyperplasia, Multifocal, Squamous | | 1 2.0|
Hyperplasia, Squamous | | 1 2.0|
Inflammation, Acute | | 1 1.0|
Ulcer | | 1 2.0|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ulcer | | 1 3.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy, Multifocal | 2 1 2 2 2 2 2 2 3 2 3 2 3 3 1 2 1 2 2 2 | 40 2.0|
Atrium, Thrombosis | | 1 |
_____________________________________________________________________________________________________________________| |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 51
NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 6| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| |
DAY ON TEST | 2| 2| 6| 2| 1| 2| 2| 8| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 7| |
| 9| 9| 4| 9| 7| 9| 9| 4| 5| 2| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 6| 9| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Degeneration, Focal | 2 1 2 | 6 1.5|
Hematopoietic Cell Proliferation, | | |
Multifocal | 2 2 | 2 2.0|
Hemorrhage | | 1 4.0|
Hyperplasia, Focal | 2 2 2 | 4 1.8|
Hyperplasia, Multifocal | 2 | 2 2.0|
|__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hemorrhage | | 1 4.0|
Hyperplasia, Focal | 1 | 5 1.6|
Hyperplasia, Multifocal | 3 | 3 3.3|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Focal | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Parathyroid Gland | + M + + M + + + + + + + + + + M + + + M + M + + +| 41 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + M + + + + + + + + + + + + + + + + + + + + + +| 49 |
Pars Distalis, Abscess | 4 | 1 4.0|
Pars Distalis, Cyst | 2 | 1 2.0|
Pars Distalis, Hemorrhage | | 1 2.0|
Pars Distalis, Hyperplasia, Focal | 2 2 2 | 7 2.0|
Pars Intermedia, Cyst | X | 1 |
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia, Focal | 2 2 | 3 2.0|
C-Cell, Hyperplasia, Multifocal | | 3 2.7|
Follicle, Cyst | X | 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 52
NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 6| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| |
DAY ON TEST | 2| 2| 6| 2| 1| 2| 2| 8| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 7| |
| 9| 9| 4| 9| 7| 9| 9| 4| 5| 2| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 6| 9| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Abscess | | 1 3.0|
Inflammation, Acute, Focal | | 1 2.0|
Inflammation, Acute, Multifocal | | 1 2.0|
Inflammation, Chronic, Focal | 2 2 1 | 3 1.7|
Inflammation, Chronic, Multifocal | 2 2 2 2 2 2 2 | 15 1.8|
Inflammation, Chronic Active, Focal | 2 2 | 2 2.0|
Inflammation, Chronic Active, | | |
Multifocal | 2 | 1 2.0|
Inflammation, Multifocal, Subacute | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia, Focal | 1 1 1 2 | 7 1.4|
Inflammation, Acute, Focal | 3 | 1 3.0|
Inflammation, Chronic, Focal | 2 2 2| 4 2.0|
Inflammation, Chronic, Multifocal | 2 | 1 2.0|
Inflammation, Chronic Active, | | |
Multifocal | | 1 3.0|
|__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Atrophy, Diffuse | 3 3 4 3 2 3 3 2 3 4 3 3 3| 27 3.0|
Dilatation | | 1 2.0|
Inflammation, Chronic, Multifocal | | 1 2.0|
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy, Diffuse | 3 3| 4 2.8|
Atrophy, Focal | 1 | 1 1.0|
Atrophy | | 1 2.0|
Granuloma Sperm | 2 | 1 2.0|
Interstitial Cell, Hyperplasia, | | |
Multifocal | 2 2 2| 5 2.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 53
NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 6| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| |
DAY ON TEST | 2| 2| 6| 2| 1| 2| 2| 8| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 7| |
| 9| 9| 4| 9| 7| 9| 9| 4| 5| 2| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 6| 9| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Blood | | 1 |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 | 3 2.0|
Infiltration Cellular, Focal, | | |
Histiocyte | | 1 2.0|
|__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + M + + + M + + +| 48 |
Degeneration, Cystic | 2 3 | 3 2.3|
Hyperplasia, Plasma Cell | | 1 1.0|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + M + + + + + + + + + + + + + + + + + + + + + +| 48 |
Congestion | | 1 2.0|
Degeneration, Cystic | | 1 3.0|
Hyperplasia, Lymphoid | 2 | 1 2.0|
Infiltration Cellular, Histiocyte | 3 2 | 3 2.3|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy, Focal | | 1 2.0|
Fibrosis, Diffuse | | 1 2.0|
Fibrosis, Focal | 2 2 | 3 2.7|
Hematopoietic Cell Proliferation | | 2 2.0|
Lymphoid Follicle, Atrophy | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Thymus | + + + + + + + M M + + + M + + + + M M M + + + + +| 39 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + M M M + + M + M + M + + M + + + + + M| 37 |
Inflammation, Chronic | 3 | 1 3.0|
Acinus, Hyperplasia, Focal | | 1 3.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 54
NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 6| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| |
DAY ON TEST | 2| 2| 6| 2| 1| 2| 2| 8| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 7| |
| 9| 9| 4| 9| 7| 9| 9| 4| 5| 2| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 6| 9| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
_____________________________________________________________________________________________________________________|____________|
INTEGUMENTARY SYSTEM - cont | | |
Duct, Ectasia | 2 2 3 | 8 2.3|
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst Epithelial Inclusion | X | 1 |
Inflammation, Acute, Focal | | 1 1.0|
Inflammation, Chronic, Focal | 2 | 1 2.0|
Subcutaneous Tissue, Fibrosis, Focal | 3 | 1 3.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperostosis | 3 | 2 2.5|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hydrocephalus | | 1 2.0|
Cerebellum, Necrosis, Focal | 2| 1 2.0|
Hypothalamus, Compression | | 3 2.3|
|__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 1 2.0|
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis, Focal | 1 | 1 1.0|
Foreign Body | 2 | 2 2.0|
Infiltration Cellular, Multifocal, | | |
Histiocyte | 1 1 | 4 1.0|
Inflammation, Acute, Multifocal | | 1 3.0|
Inflammation, Granulomatous, | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 55
NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 6| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| |
DAY ON TEST | 2| 2| 6| 2| 1| 2| 2| 8| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 7| |
| 9| 9| 4| 9| 7| 9| 9| 4| 5| 2| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 6| 9| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
Multifocal | 2 | 1 2.0|
Alveolar Epithelium, Hyperplasia, | | |
Focal | 4 | 3 3.7|
Interstitium, Inflammation, Chronic, | | |
Multifocal | | 2 2.0|
Peribronchiolar, Hyperplasia, | | |
Lymphoid | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | 2 2 | 2 2.0|
Fungus | 2 2 2 2 | 7 2.0|
Mucosa, Cytoplasmic Alteration, | | |
Multifocal | 1 1 | 2 1.0|
Mucosa, Foreign Body, Focal | 2 | 1 2.0|
Mucosa, Inflammation, Acute, Focal | | 1 3.0|
Mucosa, Inflammation, Acute, | | |
Multifocal | | 2 1.5|
Mucosa, Inflammation, Chronic, | | |
Multifocal | 2 2 | 2 2.0|
Mucosa, Inflammation, Chronic Active,| | |
Multifocal | 2 2 2 2 | 5 2.0|
Mucosa, Inflammation, Focal, Subacute| 1 | 1 1.0|
Mucosa, Inflammation, Multifocal, | | |
Subacute | 2 | 2 2.0|
Mucosa, Metaplasia, Multifocal, | | |
Squamous | | 1 2.0|
Nasolacrimal Duct, Inflammation, | | |
Chronic | 1 2 2 1 | 7 1.4|
Nasolacrimal Duct, Inflammation, | | |
Chronic Active | | 2 2.0|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 56
NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
__________________________________________________________________________________________________________________________________
| 7| 7| 6| 7| 7| 7| 7| 6| 6| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| |
DAY ON TEST | 2| 2| 6| 2| 1| 2| 2| 8| 2| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 7| |
| 9| 9| 4| 9| 7| 9| 9| 4| 5| 2| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 6| 9| 9| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
CONTROL | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
_____________________________________________________________________________________________________________________|____________|
SPECIAL SENSES SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Lens, Cataract | 4 4 3 2 | 6 3.0|
Retina, Atrophy | 4 3 1 1 1 2 2 2 2 1 2 3 | 14 2.0|
Sclera, Metaplasia, Focal, Osseous | 1 1 1 1 1 2 1 1 1 1 2 1 | 21 1.2|
Sclera, Metaplasia, Multifocal, | | |
Osseous | 3 2 2 2 1 1 2 2 2 | 22 2.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 1 2.0|
Nephropathy, Chronic, Multifocal | 3 2 2 4 3 3 1 2 2 3 3 3 1 3 3 3 2 3 3 3 2 3 2| 47 2.4|
Renal Tubule, Pigmentation | 3 | 2 2.5|
Transitional Epithelium, Hyperplasia | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Dilatation | | 1 4.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 57
NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
_____________________________________________________________________________________________________________________
| 2| 7| 7| 7| 5| 7| 7| 6| 5| 4| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 3|
DAY ON TEST | 3| 3| 3| 3| 7| 2| 2| 7| 8| 1| 2| 2| 2| 6| 5| 3| 3| 3| 8| 8| 3| 3| 3| 2| 8|
| 6| 1| 1| 1| 6| 9| 9| 4| 5| 5| 9| 9| 9| 6| 5| 0| 0| 0| 8| 2| 0| 0| 0| 3| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
20 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
LOW M/F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + M + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | M + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + M + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + M + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic, Focal | 2 2 2 |
Degeneration, Cystic, Multifocal | 2 2 |
Fatty Change | 1 2 3 1 3 |
Focal Cellular Change | X X X X X X X X X X X |
Hepatodiaphragmatic Nodule | X |
Hyperplasia, Focal | |
Hyperplasia, Multifocal | |
Inflammation, Chronic, Multifocal | 1 |
Necrosis, Acute, Multifocal | 4 |
Bile Duct, Hyperplasia, Multifocal | 2 2 2 3 3 2 2 3 2 2 3 3 1 2 2 1 2 2 1 2 1 3 1|
Centrilobular, Necrosis, Acute | 3 4 |
Vein, Thrombosis | |
|__________________________________________________________________________|
Mesentery | + + + |
Fat, Necrosis | 2 |
|__________________________________________________________________________|
Pancreas | M + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy, Focal | 2 2 1 1 |
__________________________________________|__________________________________________________________________________|
Page 58
NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
_____________________________________________________________________________________________________________________
| 2| 7| 7| 7| 5| 7| 7| 6| 5| 4| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 3|
DAY ON TEST | 3| 3| 3| 3| 7| 2| 2| 7| 8| 1| 2| 2| 2| 6| 5| 3| 3| 3| 8| 8| 3| 3| 3| 2| 8|
| 6| 1| 1| 1| 6| 9| 9| 4| 5| 5| 9| 9| 9| 6| 5| 0| 0| 0| 8| 2| 0| 0| 0| 3| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
20 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
LOW M/F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Acinus, Atrophy, Multifocal | 2 2 3 2 2 |
Acinus, Focal Cellular Change | |
Acinus, Hyperplasia, Focal | 2 |
Artery, Inflammation, Chronic | |
|__________________________________________________________________________|
Salivary Glands | + + + + + M + + + + + + + + + + + + + + + + + M +|
|__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Ulcer | |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion, Focal | |
Erosion, Multifocal | 3 |
|__________________________________________________________________________|
Tooth | + |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Blood Vessel | +|
Aorta, Arteriosclerosis | 4|
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy, Multifocal | 2 2 1 2 2 2 2 2 2 1 1 2 2 2 2 2 2 1 2 2 |
Mineralization, Multifocal | |
Atrium, Thrombosis | X X |
Valve, Inflammation, Chronic | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + M +|
Accessory Adrenal Cortical Nodule | |
Degeneration, Focal | 2 |
Hyperplasia, Focal | 2 |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 59
NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
_____________________________________________________________________________________________________________________
| 2| 7| 7| 7| 5| 7| 7| 6| 5| 4| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 3|
DAY ON TEST | 3| 3| 3| 3| 7| 2| 2| 7| 8| 1| 2| 2| 2| 6| 5| 3| 3| 3| 8| 8| 3| 3| 3| 2| 8|
| 6| 1| 1| 1| 6| 9| 9| 4| 5| 5| 9| 9| 9| 6| 5| 0| 0| 0| 8| 2| 0| 0| 0| 3| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
20 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
LOW M/F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
Adrenal Gland, Medulla | + + + + + + + + + + + M + + + + + + + M + + M +|
Hyperplasia, Focal | |
Hyperplasia, Multifocal | 2 |
|__________________________________________________________________________|
Islets, Pancreatic | M + + + + + + + + + + + + + + + + + + + + + + M +|
|__________________________________________________________________________|
Parathyroid Gland | + + M M + + + + + + + + M M + M + + M + M + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + M|
Pars Distalis, Angiectasis | 2 2 |
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia, Focal | 2 2 2 2 |
Pars Distalis, Hyperplasia, | |
Multifocal | 2 |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia, Focal | 2 2 1 2 |
C-Cell, Hyperplasia, Multifocal | 2 2 2 |
Follicle, Cyst | 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + M + + + + + + + + + + M +|
Hyperplasia, Focal | 1 |
Inflammation, Acute, Multifocal | |
Inflammation, Chronic, Diffuse | 2 2 4 |
Inflammation, Chronic, Focal | |
Inflammation, Chronic, Multifocal | 2 2 1 2 2 1 2 2 |
Inflammation, Chronic Active, Focal | 2 |
Inflammation, Chronic Active, | |
Multifocal | 2 2 |
|__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + M + + + +|
__________________________________________|__________________________________________________________________________|
Page 60
NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
_____________________________________________________________________________________________________________________
| 2| 7| 7| 7| 5| 7| 7| 6| 5| 4| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 3|
DAY ON TEST | 3| 3| 3| 3| 7| 2| 2| 7| 8| 1| 2| 2| 2| 6| 5| 3| 3| 3| 8| 8| 3| 3| 3| 2| 8|
| 6| 1| 1| 1| 6| 9| 9| 4| 5| 5| 9| 9| 9| 6| 5| 0| 0| 0| 8| 2| 0| 0| 0| 3| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
20 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
LOW M/F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
Hyperplasia, Focal | |
Inflammation, Chronic, Focal | 2 |
Inflammation, Chronic Active, Diffuse| |
Inflammation, Focal, Subacute | |
Epithelium, Hyperplasia, Multifocal | 2 |
|__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + M + + + +|
Atrophy, Diffuse | 2 2 2 3 4 2 2 4 3 2 4 3 3 2 |
Inflammation, Acute | |
|__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Diffuse | 3 4 4 4 |
Interstitial Cell, Hyperplasia, | |
Multifocal | 2 1 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 4 2 |
|__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mediastinal, Hemorrhage | 4 |
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + M + + + + + + + + + + + + + + + + + M +|
Congestion | 2 |
Degeneration, Cystic | |
Hyperplasia, Lymphoid | 2 |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Cystic | |
Hemorrhage | 2 |
Hyperplasia, Lymphoid | 2 |
Infiltration Cellular, Histiocyte | |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 4 |
Fibrosis, Focal | 3 |
Hematopoietic Cell Proliferation | 2 2 2 |
__________________________________________|__________________________________________________________________________|
Page 61
NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
_____________________________________________________________________________________________________________________
| 2| 7| 7| 7| 5| 7| 7| 6| 5| 4| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 3|
DAY ON TEST | 3| 3| 3| 3| 7| 2| 2| 7| 8| 1| 2| 2| 2| 6| 5| 3| 3| 3| 8| 8| 3| 3| 3| 2| 8|
| 6| 1| 1| 1| 6| 9| 9| 4| 5| 5| 9| 9| 9| 6| 5| 0| 0| 0| 8| 2| 0| 0| 0| 3| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
20 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
LOW M/F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
Artery, Thrombosis | X |
|__________________________________________________________________________|
Thymus | + + + + + + + + M + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + M + + + + + + + + + + + + + + + + + M + M|
Acinus, Hyperplasia, Diffuse | 2 |
Acinus, Hyperplasia, Focal | |
Duct, Ectasia | 2 3 2 |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active, Focal | |
Subcutaneous Tissue, Inflammation, | |
Chronic, Focal | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperostosis | 3 |
|__________________________________________________________________________|
Skeletal Muscle | + |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hypothalamus, Compression | 2 |
|__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage, Multifocal | 2 |
Hyperplasia, Lymphoid | 2 |
Infiltration Cellular, Focal, | |
__________________________________________|__________________________________________________________________________|
Page 62
NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
_____________________________________________________________________________________________________________________
| 2| 7| 7| 7| 5| 7| 7| 6| 5| 4| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 3|
DAY ON TEST | 3| 3| 3| 3| 7| 2| 2| 7| 8| 1| 2| 2| 2| 6| 5| 3| 3| 3| 8| 8| 3| 3| 3| 2| 8|
| 6| 1| 1| 1| 6| 9| 9| 4| 5| 5| 9| 9| 9| 6| 5| 0| 0| 0| 8| 2| 0| 0| 0| 3| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
20 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
LOW M/F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
Histiocyte | 1 |
Infiltration Cellular, Multifocal, | |
Histiocyte | 1 1 |
Inflammation, Acute, Multifocal | |
Leukocytosis | 3|
Alveolar Epithelium, Hyperplasia, | |
Multifocal | |
Interstitium, Inflammation, Chronic, | |
Multifocal | 2 1 |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fungus | 2 2 3 3 |
Inflammation, Chronic Active, | |
Multifocal | |
Mucosa, Inflammation, Acute, Focal | 2 |
Mucosa, Inflammation, Acute, | |
Multifocal | 4 |
Mucosa, Inflammation, Chronic, Focal | 2 |
Mucosa, Inflammation, Chronic, | |
Multifocal | 1 |
Mucosa, Inflammation, Chronic Active,| |
Multifocal | 1 2 2 2 3 |
Mucosa, Metaplasia, Focal, Squamous | 2 |
Nasolacrimal Duct, Inflammation, | |
Chronic | 2 2 2 |
Nasolacrimal Duct, Inflammation, | |
Chronic Active | 2 |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Ear | M M |
|__________________________________________________________________________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +|
Anterior Chamber, Hemorrhage | |
Cornea, Inflammation, Chronic Active | 2 |
Lens, Cataract | 2 3 2 1 2 2 |
__________________________________________|__________________________________________________________________________|
Page 63
NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
_____________________________________________________________________________________________________________________
| 2| 7| 7| 7| 5| 7| 7| 6| 5| 4| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 3|
DAY ON TEST | 3| 3| 3| 3| 7| 2| 2| 7| 8| 1| 2| 2| 2| 6| 5| 3| 3| 3| 8| 8| 3| 3| 3| 2| 8|
| 6| 1| 1| 1| 6| 9| 9| 4| 5| 5| 9| 9| 9| 6| 5| 0| 0| 0| 8| 2| 0| 0| 0| 3| 4|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
20 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
LOW M/F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
SPECIAL SENSES SYSTEM - cont | |
Retina, Atrophy | 4 2 4 2 |
Sclera, Metaplasia, Focal, Osseous | 1 1 1 2 2 1|
Sclera, Metaplasia, Multifocal, | |
Osseous | 2 2 1 2 2 2 2 2 1 2 2 1 2 2 2 |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
Nephropathy, Chronic, Multifocal | 2 3 3 1 2 2 2 2 2 2 2 2 1 2 2 2 2 2 3 2 3 3 |
Papilla, Necrosis | |
Pelvis, Dilatation | 2|
Renal Tubule, Mineralization, | |
Multifocal | 3|
Renal Tubule, Pigmentation | 3 |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + M + + + +|
Calculus Micro Observation Only | |
Inflammation, Hemorrhagic | 3|
Inflammation, Subacute | |
__________________________________________|__________________________________________________________________________
Page 64
NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 5| 4| 7| 7| 7| 7| 4| 7| 7| 7| 6| 6| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 9| 6| 2| 3| 3| 3| 3| 3| 6| 3| 3| 3| 9| 6| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 5| 0| 4| 0| 4| 7| 0| 0| 0| 0| 7| 0| 0| 0| 5| 7| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
20 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
LOW M/F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + M + + + +| 48 |
|__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Cystic, Focal | 1 1 1 | 6 1.5|
Degeneration, Cystic, Multifocal | | 2 2.0|
Fatty Change | 2 1 1 2| 9 1.8|
Focal Cellular Change | X X X X X X X X X X X X | 23 |
Hepatodiaphragmatic Nodule | X X X | 4 |
Hyperplasia, Focal | 3 | 1 3.0|
Hyperplasia, Multifocal | 3 | 1 3.0|
Inflammation, Chronic, Multifocal | 2 | 2 1.5|
Necrosis, Acute, Multifocal | | 1 4.0|
Bile Duct, Hyperplasia, Multifocal | 2 2 2 2 2 2 1 1 2 2 3 1 2 1 2 2 2 2 2 2 1 2 3 2| 47 2.0|
Centrilobular, Necrosis, Acute | | 2 3.5|
Vein, Thrombosis | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Mesentery | + + | 5 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 65
NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 5| 4| 7| 7| 7| 7| 4| 7| 7| 7| 6| 6| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 9| 6| 2| 3| 3| 3| 3| 3| 6| 3| 3| 3| 9| 6| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 5| 0| 4| 0| 4| 7| 0| 0| 0| 0| 7| 0| 0| 0| 5| 7| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
20 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
LOW M/F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
Fat, Necrosis | 3 | 2 2.5|
|__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Acinus, Atrophy, Focal | 2 2 1 1 2 2 2| 11 1.6|
Acinus, Atrophy, Multifocal | 1 2 2 | 8 2.0|
Acinus, Focal Cellular Change | X | 1 |
Acinus, Hyperplasia, Focal | 2 | 2 2.0|
Artery, Inflammation, Chronic | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
|__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Ulcer | 3 3 | 2 3.0|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Erosion, Focal | 2 | 1 2.0|
Erosion, Multifocal | | 1 3.0|
|__________________________________________________________________________|____________|
Tooth | | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Blood Vessel | + | 2 |
Aorta, Arteriosclerosis | 4 | 2 4.0|
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Cardiomyopathy, Multifocal | 2 2 2 2 2 2 2 2 2 2 2 3 2 2 2 2 2 2 1 2| 40 1.9|
Mineralization, Multifocal | 3 | 1 3.0|
Atrium, Thrombosis | X | 3 |
Valve, Inflammation, Chronic | 3 3 | 2 3.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 66
NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 5| 4| 7| 7| 7| 7| 4| 7| 7| 7| 6| 6| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 9| 6| 2| 3| 3| 3| 3| 3| 6| 3| 3| 3| 9| 6| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 5| 0| 4| 0| 4| 7| 0| 0| 0| 0| 7| 0| 0| 0| 5| 7| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
20 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
LOW M/F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Accessory Adrenal Cortical Nodule | X | 1 |
Degeneration, Focal | 2 2 2 2 2| 6 2.0|
Hyperplasia, Focal | 2 2 1 1 2 2 2 | 8 1.8|
|__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + M + + + + M + + + + + + + + + + + + + + + + + +| 44 |
Hyperplasia, Focal | 2 2 | 2 2.0|
Hyperplasia, Multifocal | 2 | 2 2.0|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + M + + + + +| 47 |
|__________________________________________________________________________|____________|
Parathyroid Gland | M + M + + M M + + + + + + + + + + + + + + + + + +| 39 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + M + + + + + + + + + + + + + + + + + + +| 48 |
Pars Distalis, Angiectasis | | 2 2.0|
Pars Distalis, Cyst | X | 1 |
Pars Distalis, Hyperplasia, Focal | 2 2 | 6 2.0|
Pars Distalis, Hyperplasia, | | |
Multifocal | | 1 2.0|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia, Focal | 2 2 | 6 1.8|
C-Cell, Hyperplasia, Multifocal | | 3 2.0|
Follicle, Cyst | | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 67
NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 5| 4| 7| 7| 7| 7| 4| 7| 7| 7| 6| 6| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 9| 6| 2| 3| 3| 3| 3| 3| 6| 3| 3| 3| 9| 6| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 5| 0| 4| 0| 4| 7| 0| 0| 0| 0| 7| 0| 0| 0| 5| 7| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
20 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
LOW M/F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Preputial Gland | + + M + + + + + + + + + + + + + + + + + + + + + +| 47 |
Hyperplasia, Focal | 2 | 2 1.5|
Inflammation, Acute, Multifocal | 4 | 1 4.0|
Inflammation, Chronic, Diffuse | | 3 2.7|
Inflammation, Chronic, Focal | 2 | 1 2.0|
Inflammation, Chronic, Multifocal | 1 2 2 2 3 2 1 1 1 2 1 1 1 | 21 1.6|
Inflammation, Chronic Active, Focal | | 1 2.0|
Inflammation, Chronic Active, | | |
Multifocal | 1 2 2 2 | 6 1.8|
|__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia, Focal | 2 2 2 | 3 2.0|
Inflammation, Chronic, Focal | 2 | 2 2.0|
Inflammation, Chronic Active, Diffuse| 4 | 1 4.0|
Inflammation, Focal, Subacute | 2 | 1 2.0|
Epithelium, Hyperplasia, Multifocal | | 1 2.0|
|__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Atrophy, Diffuse | 1 3 2 3 2 2 3 3 3 3 2 2 2 2 3 2| 30 2.5|
Inflammation, Acute | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy, Diffuse | 1 | 5 3.2|
Interstitial Cell, Hyperplasia, | | |
Multifocal | 1 2 2 2 2 | 8 1.8|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 2 | 6 2.3|
|__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mediastinal, Hemorrhage | | 1 4.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 68
NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 5| 4| 7| 7| 7| 7| 4| 7| 7| 7| 6| 6| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 9| 6| 2| 3| 3| 3| 3| 3| 6| 3| 3| 3| 9| 6| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 5| 0| 4| 0| 4| 7| 0| 0| 0| 0| 7| 0| 0| 0| 5| 7| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
20 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
LOW M/F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + M + + + + M + M + +| 45 |
Congestion | | 1 2.0|
Degeneration, Cystic | 2 | 1 2.0|
Hyperplasia, Lymphoid | | 1 2.0|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | M + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Degeneration, Cystic | 2 | 1 2.0|
Hemorrhage | | 1 2.0|
Hyperplasia, Lymphoid | | 1 2.0|
Infiltration Cellular, Histiocyte | 2 2 2 | 3 2.0|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + M + + + + + + + + + + + + + + +| 49 |
Congestion | | 1 4.0|
Fibrosis, Focal | | 1 3.0|
Hematopoietic Cell Proliferation | | 3 2.0|
Artery, Thrombosis | | 1 |
|__________________________________________________________________________|____________|
Thymus | + + + + + M M + + + + + + + + M + M + + + + + + +| 45 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + M + + + + + + + + + + + + + M + + + + + M + + +| 44 |
Acinus, Hyperplasia, Diffuse | | 1 2.0|
Acinus, Hyperplasia, Focal | 1 | 1 1.0|
Duct, Ectasia | 2 3 2 2 1 | 8 2.1|
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active, Focal | 2 | 1 2.0|
Subcutaneous Tissue, Inflammation, | | |
Chronic, Focal | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 69
NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 5| 4| 7| 7| 7| 7| 4| 7| 7| 7| 6| 6| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 9| 6| 2| 3| 3| 3| 3| 3| 6| 3| 3| 3| 9| 6| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 5| 0| 4| 0| 4| 7| 0| 0| 0| 0| 7| 0| 0| 0| 5| 7| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
20 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
LOW M/F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
_____________________________________________________________________________________________________________________|____________|
MUSCULOSKELETAL SYSTEM - cont | | |
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperostosis | 2 | 2 2.5|
|__________________________________________________________________________|____________|
Skeletal Muscle | | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hypothalamus, Compression | 3 4 3 | 4 3.0|
|__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage, Multifocal | | 1 2.0|
Hyperplasia, Lymphoid | | 1 2.0|
Infiltration Cellular, Focal, | | |
Histiocyte | | 1 1.0|
Infiltration Cellular, Multifocal, | | |
Histiocyte | 1 1 1 1 1 1 1 | 9 1.0|
Inflammation, Acute, Multifocal | 2 | 1 2.0|
Leukocytosis | | 1 3.0|
Alveolar Epithelium, Hyperplasia, | | |
Multifocal | 2 2| 2 2.0|
Interstitium, Inflammation, Chronic, | | |
Multifocal | | 2 1.5|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fungus | 2 2 2 2 2| 9 2.2|
Inflammation, Chronic Active, | | |
Multifocal | 2 2 | 2 2.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 70
NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 5| 4| 7| 7| 7| 7| 4| 7| 7| 7| 6| 6| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 9| 6| 2| 3| 3| 3| 3| 3| 6| 3| 3| 3| 9| 6| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 5| 0| 4| 0| 4| 7| 0| 0| 0| 0| 7| 0| 0| 0| 5| 7| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
20 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
LOW M/F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
Mucosa, Inflammation, Acute, Focal | | 1 2.0|
Mucosa, Inflammation, Acute, | | |
Multifocal | 2 | 2 3.0|
Mucosa, Inflammation, Chronic, Focal | 1 | 2 1.5|
Mucosa, Inflammation, Chronic, | | |
Multifocal | 1 | 2 1.0|
Mucosa, Inflammation, Chronic Active,| | |
Multifocal | 3 2 2| 8 2.1|
Mucosa, Metaplasia, Focal, Squamous | | 1 2.0|
Nasolacrimal Duct, Inflammation, | | |
Chronic | 2 2 2 2 1 2 2 | 10 1.9|
Nasolacrimal Duct, Inflammation, | | |
Chronic Active | 2 | 2 2.0|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Ear | + | 1 |
|__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Anterior Chamber, Hemorrhage | 4 | 1 4.0|
Cornea, Inflammation, Chronic Active | | 1 2.0|
Lens, Cataract | 1 3 3 2 | 10 2.1|
Retina, Atrophy | 1 4 4 2 2 | 9 2.8|
Sclera, Metaplasia, Focal, Osseous | 2 1 2 1 2 1 1 | 13 1.4|
Sclera, Metaplasia, Multifocal, | | |
Osseous | 2 2 2 1 1 2 2 2 2 2 2 2 2 2 2| 30 1.8|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 1 2.0|
Nephropathy, Chronic, Multifocal | 2 3 2 2 2 2 2 3 3 4 3 2 2 2 2 2 3 2 2 2 2 2 2 2| 46 2.2|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 71
NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 5| 4| 7| 7| 7| 7| 4| 7| 7| 7| 6| 6| |
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 9| 6| 2| 3| 3| 3| 3| 3| 6| 3| 3| 3| 9| 6| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 5| 0| 4| 0| 4| 7| 0| 0| 0| 0| 7| 0| 0| 0| 5| 7| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
20 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
LOW M/F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
_____________________________________________________________________________________________________________________|____________|
URINARY SYSTEM - cont | | |
Papilla, Necrosis | 4 | 1 4.0|
Pelvis, Dilatation | 2 | 2 2.0|
Renal Tubule, Mineralization, | | |
Multifocal | | 1 3.0|
Renal Tubule, Pigmentation | 2 2| 3 2.3|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Calculus Micro Observation Only | 2 | 1 2.0|
Inflammation, Hemorrhagic | | 1 3.0|
Inflammation, Subacute | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 72
NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 7| 7| 6| 6| 4| 7| 7| 7| 7| 5| 7| 7| 7| 6| 6| 7| 7| 6| 7| 6|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 6| 2| 9| 3| 2| 3| 1| 8| 3| 3| 3| 7| 2| 3| 3| 0| 3| 6|
| 0| 0| 0| 0| 6| 0| 0| 6| 7| 8| 0| 6| 0| 1| 2| 0| 0| 0| 5| 1| 0| 0| 7| 0| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
100 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
HIGH M/F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM | |
|__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + A + + + + + + + + + + + + + A + +|
|__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + A + + + + + + + + + + + + + + +|
Ectopic Tissue | X |
|__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + A + + + + + + + + + + + + A + +|
|__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Basophilic Focus | 1 1 |
Degeneration, Cystic, Focal | 4 |
Fatty Change | 1 2 4|
Focal Cellular Change | X X X X X X X X X X X X X |
Hepatodiaphragmatic Nodule | X |
Hyperplasia, Multifocal | 3 |
Inflammation, Chronic, Multifocal | |
Necrosis, Acute, Multifocal | |
Bile Duct, Hyperplasia, Multifocal | 1 2 1 2 2 2 2 1 2 1 2 2 1 2 2 3 3 2 2 2 2 2|
Centrilobular, Congestion, Chronic | 3 |
|__________________________________________________________________________|
Mesentery | |
Fat, Necrosis | |
|__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Atrophy, Diffuse | |
Acinus, Atrophy, Focal | 2 1 1 3 3 |
__________________________________________|__________________________________________________________________________|
Page 73
NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 7| 7| 6| 6| 4| 7| 7| 7| 7| 5| 7| 7| 7| 6| 6| 7| 7| 6| 7| 6|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 6| 2| 9| 3| 2| 3| 1| 8| 3| 3| 3| 7| 2| 3| 3| 0| 3| 6|
| 0| 0| 0| 0| 6| 0| 0| 6| 7| 8| 0| 6| 0| 1| 2| 0| 0| 0| 5| 1| 0| 0| 7| 0| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
100 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
HIGH M/F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ALIMENTARY SYSTEM - cont | |
Acinus, Atrophy, Multifocal | 2 |
Artery, Inflammation, Chronic | 4 |
|__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion | |
Inflammation, Chronic Active, Diffuse| |
Inflammation, Subacute | |
Ulcer | |
|__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Erosion, Focal | 2 2 |
|__________________________________________________________________________|
Tooth | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
|__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy, Multifocal | 1 1 1 1 1 2 2 1 1 2 2 2 2 1 2 2 2 1 2 2 2 |
Atrium, Thrombosis | 2 X X |
Coronary Artery, Inflammation, | |
Chronic | 3 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
|__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Degeneration, Focal | 2 2 |
Degeneration, Multifocal | |
Hematopoietic Cell Proliferation, | |
Multifocal | 2 1 |
Hyperplasia, Focal | 1 |
Hyperplasia, Multifocal | 1 |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 74
NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 7| 7| 6| 6| 4| 7| 7| 7| 7| 5| 7| 7| 7| 6| 6| 7| 7| 6| 7| 6|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 6| 2| 9| 3| 2| 3| 1| 8| 3| 3| 3| 7| 2| 3| 3| 0| 3| 6|
| 0| 0| 0| 0| 6| 0| 0| 6| 7| 8| 0| 6| 0| 1| 2| 0| 0| 0| 5| 1| 0| 0| 7| 0| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
100 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
HIGH M/F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 1 1 |
|__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 |
|__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + + + M + + + + + + + + + + + + +|
|__________________________________________________________________________|
Pituitary Gland | + + + + + + + + + M + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Pars Distalis, Angiectasis | |
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia, Focal | 2 2 4 1 |
Pars Distalis, Hyperplasia, | |
Multifocal | 2 |
|__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
C-Cell, Hyperplasia, Focal | 1 2 |
Follicle, Cyst | X 2 |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
|__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
Granuloma Sperm | |
|__________________________________________________________________________|
Preputial Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 2 |
Hyperplasia, Focal | |
Inflammation, Chronic, Diffuse | |
Inflammation, Chronic, Focal | 1 2 |
Inflammation, Chronic, Multifocal | 1 2 1 2 2 2|
Inflammation, Chronic Active, Focal | |
Inflammation, Chronic Active, | |
Multifocal | 2 2 2 |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 75
NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 7| 7| 6| 6| 4| 7| 7| 7| 7| 5| 7| 7| 7| 6| 6| 7| 7| 6| 7| 6|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 6| 2| 9| 3| 2| 3| 1| 8| 3| 3| 3| 7| 2| 3| 3| 0| 3| 6|
| 0| 0| 0| 0| 6| 0| 0| 6| 7| 8| 0| 6| 0| 1| 2| 0| 0| 0| 5| 1| 0| 0| 7| 0| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
100 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
HIGH M/F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
GENITAL SYSTEM - cont | |
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia, Focal | 2 |
Hyperplasia, Multifocal | 2 2 |
Inflammation, Acute, Multifocal | |
Inflammation, Chronic Active, | |
Multifocal | 2|
|__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Diffuse | 2 3 2 2 3 3 2 4 2 3 4 3 2 3 3 3 2 4 4|
Dilatation | |
Inflammation, Chronic, Focal | |
|__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy, Diffuse | 3 |
Atrophy, Focal | |
Interstitial Cell, Hyperplasia, | |
Multifocal | 2|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
|__________________________________________________________________________|
Blood | |
|__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 2 |
|__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + M + +|
Congestion | 2 |
Degeneration, Cystic | |
Hyperplasia, Lymphoid | 2 |
Hyperplasia, Plasma Cell | 2 |
|__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Infiltration Cellular, Histiocyte | 1 2 2 |
|__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________|
Page 76
NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 7| 7| 6| 6| 4| 7| 7| 7| 7| 5| 7| 7| 7| 6| 6| 7| 7| 6| 7| 6|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 6| 2| 9| 3| 2| 3| 1| 8| 3| 3| 3| 7| 2| 3| 3| 0| 3| 6|
| 0| 0| 0| 0| 6| 0| 0| 6| 7| 8| 0| 6| 0| 1| 2| 0| 0| 0| 5| 1| 0| 0| 7| 0| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
100 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
HIGH M/F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
Fibrosis, Focal | |
Hematopoietic Cell Proliferation | 2 |
Lymphoid Follicle, Atrophy | 2 2 |
|__________________________________________________________________________|
Thymus | + + + + + M M + + + + M + + M + + + M + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
|__________________________________________________________________________|
Mammary Gland | + + + + + + + + M + + + + + + + + + + + + + + + +|
Duct, Ectasia | 2 2 |
|__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hair Follicle, Atrophy | |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
|__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
|__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cerebrum, Necrosis, Focal | |
Hypothalamus, Compression | 3 |
|__________________________________________________________________________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
|__________________________________________________________________________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + +|
|__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess, Multifocal | 3 |
Foreign Body | |
Infiltration Cellular, Multifocal, | |
Histiocyte | 1 1 1 |
Inflammation, Acute, Multifocal | |
Alveolar Epithelium, Hyperplasia, | |
Focal | 4 3 |
__________________________________________|__________________________________________________________________________|
Page 77
NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 7| 7| 6| 6| 4| 7| 7| 7| 7| 5| 7| 7| 7| 6| 6| 7| 7| 6| 7| 6|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 6| 2| 9| 3| 2| 3| 1| 8| 3| 3| 3| 7| 2| 3| 3| 0| 3| 6|
| 0| 0| 0| 0| 6| 0| 0| 6| 7| 8| 0| 6| 0| 1| 2| 0| 0| 0| 5| 1| 0| 0| 7| 0| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
100 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
HIGH M/F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
|__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +|
Foreign Body | 2 |
Fungus | 2 |
Metaplasia, Focal, Squamous | |
Mucosa, Inflammation, Chronic, | |
Multifocal | 2 |
Mucosa, Inflammation, Chronic Active,| |
Multifocal | 4 |
Mucosa, Inflammation, Multifocal, | |
Subacute | |
Mucosa, Metaplasia, Multifocal, | |
Squamous | |
Nasolacrimal Duct, Inflammation, | |
Chronic | 2 |
Nasolacrimal Duct, Inflammation, | |
Chronic Active | |
Nasolacrimal Duct, Inflammation, | |
Subacute | |
|__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
|__________________________________________________________________________|
Ear | M |
|__________________________________________________________________________|
Eye | + + + + + + + M + M + + + + + + + + + + + + + + +|
Inflammation, Chronic | |
Lens, Cataract | 1 2 1 2 |
Retina, Atrophy | 1 3 |
Sclera, Metaplasia, Focal, Osseous | 1 1 1 1 1 1 1 1 1 |
Sclera, Metaplasia, Multifocal, | |
Osseous | 1 2 2 2 2 1 2 2 2|
|__________________________________________________________________________|
Zymbal's Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
|__________________________________________________________________________|
__________________________________________|__________________________________________________________________________|
Page 78
NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 4| 7| 7| 6| 6| 4| 7| 7| 7| 7| 5| 7| 7| 7| 6| 6| 7| 7| 6| 7| 6|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 6| 2| 9| 3| 2| 3| 1| 8| 3| 3| 3| 7| 2| 3| 3| 0| 3| 6|
| 0| 0| 0| 0| 6| 0| 0| 6| 7| 8| 0| 6| 0| 1| 2| 0| 0| 0| 5| 1| 0| 0| 7| 0| 0|
__________________________________________|__________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
100 PPM | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
HIGH M/F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
__________________________________________|__________________________________________________________________________|
URINARY SYSTEM - cont | |
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | 2 |
Nephropathy, Chronic, Multifocal | 2 3 1 2 1 2 2 2 3 1 3 2 2 1 3 1 2 2 1 2 2|
Renal Tubule, Pigmentation | 2 |
|__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________|__________________________________________________________________________
Page 79
NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| |
DAY ON TEST | 3| 3| 3| 0| 5| 3| 3| 3| 9| 3| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| |
| 0| 0| 0| 3| 9| 0| 0| 0| 5| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 2| 9| 9| 9| 6| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
100 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
HIGH M/F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Intestine Large | + + + + A + + + + + + + + + + + + + A + + + + +| 46 |
|__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + A + + + + + + + + + + + + + A + + + + +| 44 |
|__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + A + + + + + + + + + + + + + A + + + + +| 46 |
|__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + A + + + + + + + M + + + + + A + + + + +| 45 |
|__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + A + + + + +| 49 |
|__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + A + + + + +| 48 |
Ectopic Tissue | | 1 |
|__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + A + + + + + + + + + + + + + + A + + + + +| 48 |
|__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + A + + + + + + + + + + + + + + A + + + + +| 46 |
|__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Basophilic Focus | | 2 1.0|
Degeneration, Cystic, Focal | 1 1 | 3 2.0|
Fatty Change | 2 3 2| 6 2.3|
Focal Cellular Change | X X X X X X X X X X X X X X X X X X X| 32 |
Hepatodiaphragmatic Nodule | X | 2 |
Hyperplasia, Multifocal | 2 | 2 2.5|
Inflammation, Chronic, Multifocal | 1 1 | 2 1.0|
Necrosis, Acute, Multifocal | 2 | 1 2.0|
Bile Duct, Hyperplasia, Multifocal | 2 3 2 2 2 3 2 2 3 2 3 2 2 1 2 3 2 2 2 1 2 2 3| 45 2.0|
Centrilobular, Congestion, Chronic | | 1 3.0|
|__________________________________________________________________________|____________|
Mesentery | + + + + + | 5 |
Fat, Necrosis | 3 3 3 3 | 4 3.0|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 80
NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| |
DAY ON TEST | 3| 3| 3| 0| 5| 3| 3| 3| 9| 3| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| |
| 0| 0| 0| 3| 9| 0| 0| 0| 5| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 2| 9| 9| 9| 6| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
100 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
HIGH M/F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
_____________________________________________________________________________________________________________________|____________|
ALIMENTARY SYSTEM - cont | | |
|__________________________________________________________________________|____________|
Pancreas | + + + + A + + + + + + + + + + + + + + + + + + + +| 49 |
Acinus, Atrophy, Diffuse | 4 2| 2 3.0|
Acinus, Atrophy, Focal | 1 2 | 7 1.9|
Acinus, Atrophy, Multifocal | 2 2 3 2 1 2 2 | 8 2.0|
Artery, Inflammation, Chronic | | 1 4.0|
|__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Erosion | 2 | 1 2.0|
Inflammation, Chronic Active, Diffuse| 3 | 1 3.0|
Inflammation, Subacute | 2 | 1 2.0|
Ulcer | 2 2 | 2 2.0|
|__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Erosion, Focal | | 2 2.0|
|__________________________________________________________________________|____________|
Tooth | + | 1 |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
|__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cardiomyopathy, Multifocal | 1 3 2 2 2 1 2 2 2 2 2 2 1 1 2 2 1 2 2| 40 1.7|
Atrium, Thrombosis | 4 | 4 3.0|
Coronary Artery, Inflammation, | | |
Chronic | 2 | 2 2.5|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
|__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 81
NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| |
DAY ON TEST | 3| 3| 3| 0| 5| 3| 3| 3| 9| 3| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| |
| 0| 0| 0| 3| 9| 0| 0| 0| 5| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 2| 9| 9| 9| 6| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
100 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
HIGH M/F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
_____________________________________________________________________________________________________________________|____________|
ENDOCRINE SYSTEM - cont | | |
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Degeneration, Focal | 2 | 3 2.0|
Degeneration, Multifocal | 1 | 1 1.0|
Hematopoietic Cell Proliferation, | | |
Multifocal | 2 1 1 | 5 1.4|
Hyperplasia, Focal | 1 2 | 3 1.3|
Hyperplasia, Multifocal | 3 | 2 2.0|
|__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Focal | | 2 1.0|
|__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Focal | 3 | 2 2.5|
|__________________________________________________________________________|____________|
Parathyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
|__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hemorrhage | | 1 2.0|
Pars Distalis, Angiectasis | 2 | 1 2.0|
Pars Distalis, Cyst | 2 2 2 | 3 2.0|
Pars Distalis, Hyperplasia, Focal | 3 2 3 | 7 2.4|
Pars Distalis, Hyperplasia, | | |
Multifocal | 2 | 2 2.0|
|__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
C-Cell, Hyperplasia, Focal | 3 3 2 | 5 2.2|
Follicle, Cyst | | 2 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
|__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 82
NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| |
DAY ON TEST | 3| 3| 3| 0| 5| 3| 3| 3| 9| 3| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| |
| 0| 0| 0| 3| 9| 0| 0| 0| 5| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 2| 9| 9| 9| 6| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
100 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
HIGH M/F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
_____________________________________________________________________________________________________________________|____________|
GENITAL SYSTEM - cont | | |
Granuloma Sperm | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Preputial Gland | + + + M + + + + + + + + + + + + + + + + + + + + +| 49 |
Abscess | 4 | 2 3.0|
Hyperplasia, Focal | 3 | 1 3.0|
Inflammation, Chronic, Diffuse | 2 | 1 2.0|
Inflammation, Chronic, Focal | 2 1 2 | 5 1.6|
Inflammation, Chronic, Multifocal | 1 1 2 3 2 2 2 1 3 1 1 | 17 1.7|
Inflammation, Chronic Active, Focal | 2 | 1 2.0|
Inflammation, Chronic Active, | | |
Multifocal | 2 1| 5 1.8|
|__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia, Focal | 1 1 | 3 1.3|
Hyperplasia, Multifocal | | 2 2.0|
Inflammation, Acute, Multifocal | 2 | 1 2.0|
Inflammation, Chronic Active, | | |
Multifocal | | 1 2.0|
|__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + M + + + + + + + + +| 49 |
Atrophy, Diffuse | 3 3 3 3 3 4 3 3 4 4 2 3 4 4 3 3 2| 36 3.0|
Dilatation | 3 | 1 3.0|
Inflammation, Chronic, Focal | 3 | 1 3.0|
|__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy, Diffuse | | 1 3.0|
Atrophy, Focal | 2| 1 2.0|
Interstitial Cell, Hyperplasia, | | |
Multifocal | 2| 2 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
|__________________________________________________________________________|____________|
Blood | + | 1 |
|__________________________________________________________________________|____________|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 83
NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| |
DAY ON TEST | 3| 3| 3| 0| 5| 3| 3| 3| 9| 3| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| |
| 0| 0| 0| 3| 9| 0| 0| 0| 5| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 2| 9| 9| 9| 6| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
100 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
HIGH M/F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
_____________________________________________________________________________________________________________________|____________|
HEMATOPOIETIC SYSTEM - cont | | |
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 2 2 2 2 | 6 2.0|
|__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
|__________________________________________________________________________|____________|
Lymph Node, Mandibular | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Congestion | | 1 2.0|
Degeneration, Cystic | 2 | 1 2.0|
Hyperplasia, Lymphoid | 2 2 | 3 2.0|
Hyperplasia, Plasma Cell | | 1 2.0|
|__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hemorrhage | 3 | 1 3.0|
Infiltration Cellular, Histiocyte | 1 1 | 5 1.4|
|__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fibrosis, Focal | 2 | 1 2.0|
Hematopoietic Cell Proliferation | | 1 2.0|
Lymphoid Follicle, Atrophy | 2 4 | 4 2.5|
|__________________________________________________________________________|____________|
Thymus | + + + M M + + + + + + + + + + + + + + + + + + + +| 43 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
|__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + + + M + + + + + + + + + + + + +| 48 |
Duct, Ectasia | 3 2 | 4 2.3|
|__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hair Follicle, Atrophy | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
|__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 84
NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| |
DAY ON TEST | 3| 3| 3| 0| 5| 3| 3| 3| 9| 3| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| |
| 0| 0| 0| 3| 9| 0| 0| 0| 5| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 2| 9| 9| 9| 6| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
100 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
HIGH M/F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
_____________________________________________________________________________________________________________________|____________|
NERVOUS SYSTEM | | |
|__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cerebrum, Necrosis, Focal | 4 | 1 4.0|
Hypothalamus, Compression | | 1 3.0|
|__________________________________________________________________________|____________|
Spinal Cord | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
|__________________________________________________________________________|____________|
Larynx | + + + + + + + + + + + + + + + + + + + + + + + + | 49 |
|__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Abscess, Multifocal | | 1 3.0|
Foreign Body | 2 | 1 2.0|
Infiltration Cellular, Multifocal, | | |
Histiocyte | 1 1 1 | 6 1.0|
Inflammation, Acute, Multifocal | 2 | 1 2.0|
Alveolar Epithelium, Hyperplasia, | | |
Focal | 3 3 | 4 3.3|
|__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Foreign Body | 2 1 | 3 1.7|
Fungus | 2 2 2 | 4 2.0|
Metaplasia, Focal, Squamous | 1 | 1 1.0|
Mucosa, Inflammation, Chronic, | | |
Multifocal | | 1 2.0|
Mucosa, Inflammation, Chronic Active,| | |
Multifocal | 2 2 2 3 | 5 2.6|
Mucosa, Inflammation, Multifocal, | | |
Subacute | 2 2 | 2 2.0|
Mucosa, Metaplasia, Multifocal, | | |
Squamous | 3 | 1 3.0|
Nasolacrimal Duct, Inflammation, | | |
Chronic | 2 2 1 1 1 | 6 1.5|
_____________________________________________________________________________________________________________________|____________|
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 85
NTP Experiment-Test: 05029-01 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC DL AMPHETAMINE SULFATE Date: 12/20/01
Route: DOSED FEED Time: 10:01:32
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 7| |
DAY ON TEST | 3| 3| 3| 0| 5| 3| 3| 3| 9| 3| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| |
| 0| 0| 0| 3| 9| 0| 0| 0| 5| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 2| 9| 9| 9| 6| 0| |
__________________________________________|__________________________________________________________________________| T (*) |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
FISCHER 344 RATS MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
100 PPM | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
HIGH M/F | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
_____________________________________________________________________________________________________________________|____________|
RESPIRATORY SYSTEM - cont | | |
Nasolacrimal Duct, Inflammation, | | |
Chronic Active | 2 | 1 2.0|
Nasolacrimal Duct, Inflammation, | | |
Subacute | 2 | 1 2.0|
|__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
|__________________________________________________________________________|____________|
Ear | M | |
|__________________________________________________________________________|____________|
Eye | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Inflammation, Chronic | 4 | 1 4.0|
Lens, Cataract | 2 1 | 6 1.5|
Retina, Atrophy | 1 | 3 1.7|
Sclera, Metaplasia, Focal, Osseous | 1 1 1 1 1 | 14 1.0|
Sclera, Metaplasia, Multifocal, | | |
Osseous | 2 2 1 1 1 2 2 2 2 2 1 1 1 2 2 1 2| 26 1.7|
|__________________________________________________________________________|____________|
Zymbal's Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
|__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | | 1 2.0|
Nephropathy, Chronic, Multifocal | 2 2 1 2 1 2 2 2 2 2 2 1 2 2 2 1 1 2 2 2 2 1 1 2| 45 1.8|
Renal Tubule, Pigmentation | 2 2 2 | 4 2.0|
|__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 86
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