TR 388 Mouse Pathology Tables
INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
ETHYLENETHIOUREA
NTP Experiment-Test: 05076-02 Report: PEIRPT03
Study Type: CHRONIC Date: 09/10/94
Route: DOSED FEED Time: 02:00:00
Facility: Battelle Columbus Laboratory
Chemical CAS #: 96-45-7
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05076-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ETHYLENETHIOUREA Date: 09/10/94
Route: DOSED FEED Time: 02:00:00
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 0 PPM 100 PPM 333 PPM 333 PPM 333 PPM
0-0 10-0 1-1 0-3 3-3 10-3
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 29 50 50 50
Early Deaths
Moribund Sacrifice 9 4 6 6 11 9
Natural Death 6 8 2 1 3 5
Survivors
Terminal Sacrifice 34 37 21 42 34 36
Natural Death 1 1 1 2
Animals Examined Microscopically 50 50 29 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (49) (12) (8) (9) (16) (12)
Parasite Metazoan 1 (6%)
Intestine Small, Jejunum (46) (12) (10) (8) (19) (13)
Inflammation, Chronic Active 1 (8%)
Necrosis 1 (8%)
Peyer's Patch, Hyperplasia, Lymphoid 1 (10%)
Liver (50) (49) (28) (50) (50) (50)
Basophilic Focus 2 (4%) 1 (2%) 3 (6%) 2 (4%) 1 (2%)
Clear Cell Focus 2 (4%) 1 (2%) 1 (2%)
Eosinophilic Focus 2 (7%) 11 (22%) 4 (8%) 14 (28%)
Fatty Change, Focal 1 (2%)
Hematopoietic Cell Proliferation 8 (16%) 2 (4%) 1 (4%) 1 (2%) 4 (8%) 2 (4%)
Hyperplasia, Lymphoid 1 (2%)
Infarct 3 (6%) 2 (4%) 2 (7%) 5 (10%) 6 (12%) 4 (8%)
Inflammation, Acute 1 (2%) 1 (2%)
Inflammation, Chronic Active 2 (4%) 1 (2%) 1 (2%)
Necrosis 2 (4%) 1 (2%)
Vacuolization Cytoplasmic 1 (2%)
Bile Duct, Mineralization, Multifocal 1 (2%)
Centrilobular, Cytomegaly 2 (7%) 11 (22%) 8 (16%) 9 (18%)
Centrilobular, Necrosis 1 (2%)
Centrilobular, Necrosis, Acute 1 (2%)
Centrilobular, Vacuolization Cytoplasmic 2 (4%) 1 (2%)
Oval Cell, Hyperplasia 1 (2%)
Mesentery (6) (2) (1) (1) (1)
Inflammation, Chronic Active 2 (33%) 1 (100%) 1 (100%)
Pancreas (50) (11) (8) (7) (16) (13)
Acinus, Atrophy 2 (4%) 1 (13%) 1 (14%) 1 (6%) 2 (15%)
Acinus, Inflammation, Chronic Active 1 (14%)
Duct, Ectasia 2 (4%) 1 (6%) 2 (15%)
Salivary Glands (50) (13) (8) (8) (15) (14)
Perivascular, Inflammation, Chronic Active,
Multifocal 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05076-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ETHYLENETHIOUREA Date: 09/10/94
Route: DOSED FEED Time: 02:00:00
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 0 PPM 100 PPM 333 PPM 333 PPM 333 PPM
0-0 10-0 1-1 0-3 3-3 10-3
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Stomach, Forestomach (48) (15) (10) (11) (17) (14)
Acanthosis 2 (18%)
Cyst Epithelial Inclusion 2 (13%) 1 (10%)
Diverticulum 1 (6%)
Hyperkeratosis, Focal 1 (7%)
Hyperplasia, Squamous 1 (10%) 3 (18%)
Inflammation, Chronic Active 2 (13%)
Stomach, Glandular (48) (11) (8) (8) (15) (13)
Dysplasia 1 (2%)
Subserosa, Inflammation, Chronic 1 (13%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (13) (8) (8) (16) (14)
Bacterium, Acute, Multiple 1 (2%) 2 (13%)
Degeneration, Chronic 1 (6%)
Inflammation, Acute 2 (13%)
Inflammation, Chronic 1 (7%)
Mineralization 1 (13%) 1 (13%)
Thrombosis 1 (2%) 1 (13%)
Interstitium, Hyperplasia, Diffuse 1 (7%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (49) (13) (8) (8) (16) (11)
Degeneration, Fatty 4 (8%)
Hematopoietic Cell Proliferation 1 (8%)
Hyperplasia 1 (2%)
Hypertrophy 3 (6%) 1 (6%) 1 (9%)
Adrenal Gland, Medulla (48) (13) (8) (8) (16) (11)
Hyperplasia 1 (13%) 1 (6%)
Islets, Pancreatic (49) (13) (8) (7) (15) (12)
Hyperplasia, Focal 1 (2%)
Pituitary Gland (47) (48) (28) (49) (48) (47)
Pars Distalis, Angiectasis 1 (2%)
Pars Distalis, Hyperplasia 19 (40%) 19 (40%) 8 (29%) 22 (45%) 23 (48%) 18 (38%)
Thyroid Gland (50) (49) (29) (50) (50) (49)
Follicular Cell, Hyperplasia 2 (4%) 8 (16%) 13 (26%) 17 (34%) 22 (45%)
Follicular Cell, Vacuolization Cytoplasmic 3 (6%) 1 (2%) 19 (66%) 49 (98%) 49 (98%) 44 (90%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05076-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ETHYLENETHIOUREA Date: 09/10/94
Route: DOSED FEED Time: 02:00:00
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 0 PPM 100 PPM 333 PPM 333 PPM 333 PPM
0-0 10-0 1-1 0-3 3-3 10-3
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (1) (1)
Dilatation 1 (100%) 1 (100%)
Ovary (49) (26) (20) (15) (24) (25)
Angiectasis 2 (10%)
Hemorrhage 1 (4%)
Inflammation, Suppurative 1 (2%) 2 (8%)
Thrombosis 1 (5%)
Follicle, Cyst 16 (33%) 8 (31%) 8 (40%) 6 (40%) 11 (46%) 8 (32%)
Periovarian Tissue, Cyst 3 (6%) 9 (35%) 2 (13%) 3 (13%) 4 (16%)
Uterus (48) (33) (13) (19) (20) (20)
Angiectasis 2 (10%)
Dilatation 2 (4%) 2 (10%)
Endometrium, Hyperplasia, Cystic, Glandular 39 (81%) 28 (85%) 7 (54%) 13 (68%) 8 (40%) 9 (45%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (49) (13) (8) (8) (16) (13)
Angiectasis 1 (13%)
Femoral, Hyperplasia, Neutrophil 1 (8%)
Femoral, Necrosis, Acute 1 (8%)
Lymph Node (49) (18) (15) (19) (25) (19)
Lumbar, Sinus, Lymphatic, Ectasia 1 (2%)
Mandibular, Angiectasis 1 (6%)
Mandibular, Hyperplasia, Lymphoid 2 (4%) 1 (6%) 1 (5%)
Mandibular, Hyperplasia, Reticulum Cell 1 (5%)
Mandibular, Infiltration Cellular, Plasma
Cell 1 (2%)
Mediastinal, Hyperplasia, Lymphoid 1 (2%)
Lymph Node, Mesenteric (14) (10) (8) (12) (14) (9)
Hematopoietic Cell Proliferation 2 (14%) 1 (10%) 2 (25%) 2 (17%) 1 (7%) 1 (11%)
Hemorrhage 1 (7%)
Hyperplasia, Lymphoid 1 (7%)
Inflammation, Chronic Active 1 (11%)
Spleen (50) (23) (13) (28) (31) (34)
Fibrosis 1 (2%) 1 (3%)
Hematopoietic Cell Proliferation 5 (10%) 3 (13%) 6 (21%) 6 (19%) 5 (15%)
Hyperplasia, Lymphoid 3 (6%) 1 (4%) 2 (7%) 3 (10%) 3 (9%)
Necrosis, Acute 1 (3%)
Thymus (39) (7) (4) (6) (12) (5)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05076-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ETHYLENETHIOUREA Date: 09/10/94
Route: DOSED FEED Time: 02:00:00
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 0 PPM 100 PPM 333 PPM 333 PPM 333 PPM
0-0 10-0 1-1 0-3 3-3 10-3
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Depletion Lymphoid 1 (8%) 1 (20%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (35) (13) (8) (8) (16) (11)
Hyperplasia, Cystic 1 (3%)
Skin (50) (13) (8) (8) (16) (15)
Acanthosis 5 (10%) 4 (50%) 8 (50%)
Parasite External 6 (12%) 6 (75%) 11 (69%) 1 (7%)
Ulcer 1 (2%)
Subcutaneous Tissue, Fibrosis 1 (2%)
Subcutaneous Tissue, Inflammation, Chronic
Active 1 (6%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (13) (9) (9) (16) (14)
Tarsal, Hyperostosis 2 (22%) 1 (11%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (13) (8) (8) (16) (14)
Compression 2 (4%) 1 (8%) 1 (13%)
Hemorrhage 2 (4%) 1 (13%)
Hydrocephalus 2 (4%)
Perivascular, Inflammation, Chronic Active 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (29) (50) (50) (50)
Alveolar Epithelium, Hyperplasia 1 (2%) 1 (2%) 1 (2%) 1 (2%)
Artery, Embolus 1 (2%)
Interstitium, Inflammation, Acute 1 (2%)
Mediastinum, Hyperplasia, Lymphoid 1 (2%)
Peribronchiolar, Inflammation, Chronic Active 13 (26%) 5 (10%) 2 (7%) 7 (14%) 1 (2%) 2 (4%)
Nose (47) (12) (8) (8) (16) (13)
Nasolacrimal Duct, Inflammation, Acute 1 (8%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05076-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ETHYLENETHIOUREA Date: 09/10/94
Route: DOSED FEED Time: 02:00:00
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 0 PPM 0 PPM 100 PPM 333 PPM 333 PPM 333 PPM
0-0 10-0 1-1 0-3 3-3 10-3
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (2) (2) (1)
Atrophy 1 (50%) 2 (100%) 1 (100%)
Lens, Cataract 1 (50%)
Retina, Degeneration 1 (50%)
Harderian Gland (3) (3) (1) (4) (1) (1)
Inflammation, Chronic Active 1 (100%)
Lacrimal Gland (1)
Inflammation, Chronic Active 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (12) (8) (11) (16) (15)
Hemorrhage 1 (13%)
Infarct 1 (2%)
Nephropathy, Chronic 1 (13%) 1 (9%)
Glomerulus, Dilatation 1 (8%)
Glomerulus, Inflammation, Acute 1 (7%)
Glomerulus, Inflammation, Chronic 1 (7%)
Pelvis, Inflammation, Suppurative 1 (2%)
Renal Tubule, Cyst 1 (2%)
Renal Tubule, Dilatation 1 (6%)
Urinary Bladder (48) (12) (8) (9) (13) (11)
Inflammation, Acute 1 (2%)
Inflammation, Chronic Active 1 (8%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05076-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ETHYLENETHIOUREA Date: 09/10/94
Route: DOSED FEED Time: 02:00:00
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 1000 PPM 1000 PPM
0-10 10-10
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50
Early Deaths
Natural Death 9 7
Moribund Sacrifice 10 14
Survivors
Natural Death 1
Terminal Sacrifice 30 29
Animals Examined Microscopically 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Cecum (50) (48)
Inflammation, Chronic Active 1 (2%)
Intestine Large, Colon (50) (49)
Parasite Metazoan 3 (6%)
Liver (50) (50)
Angiectasis 1 (2%)
Eosinophilic Focus 3 (6%) 2 (4%)
Hematopoietic Cell Proliferation 1 (2%) 2 (4%)
Hyperplasia, Lymphoid 1 (2%)
Infarct 13 (26%) 22 (44%)
Infiltration Cellular, Multifocal, Histiocyte 1 (2%)
Inflammation, Chronic Active 1 (2%)
Mixed Cell Focus 1 (2%)
Centrilobular, Cytomegaly 8 (16%)
Centrilobular, Vacuolization Cytoplasmic 1 (2%)
Mesentery (2) (1)
Inflammation, Chronic Active 1 (100%)
Pancreas (50) (50)
Acinus, Atrophy 1 (2%) 1 (2%)
Duct, Ectasia 1 (2%) 1 (2%)
Perivascular, Inflammation, Chronic Active 1 (2%)
Salivary Glands (49) (50)
Hyperplasia, Lymphoid 1 (2%)
Perivascular, Inflammation, Chronic Active,
Multifocal 1 (2%)
Stomach, Forestomach (49) (50)
Acanthosis 1 (2%) 1 (2%)
Diverticulum 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05076-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ETHYLENETHIOUREA Date: 09/10/94
Route: DOSED FEED Time: 02:00:00
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 1000 PPM 1000 PPM
0-10 10-10
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50)
Degeneration, Chronic 1 (2%)
Inflammation, Chronic 1 (2%)
Mineralization 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (49) (50)
Accessory Adrenal Cortical Nodule 1 (2%)
Hematopoietic Cell Proliferation 1 (2%)
Hypertrophy 1 (2%) 1 (2%)
Adrenal Gland, Medulla (50) (50)
Hemorrhage, Chronic 1 (2%)
Hyperplasia 1 (2%)
Pituitary Gland (49) (47)
Pars Distalis, Cyst 1 (2%)
Pars Distalis, Hyperplasia 27 (55%) 28 (60%)
Pars Distalis, Vacuolization Cytoplasmic 2 (4%)
Thyroid Gland (50) (50)
Follicular Cell, Hyperplasia 46 (92%) 46 (92%)
Follicular Cell, Vacuolization Cytoplasmic 47 (94%) 48 (96%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (50) (48)
Hyperplasia, Tubular 1 (2%)
Inflammation, Suppurative 1 (2%)
Follicle, Cyst 8 (16%) 7 (15%)
Periovarian Tissue, Cyst 2 (4%) 2 (4%)
Periovarian Tissue, Hyperplasia, Lymphoid 1 (2%)
Uterus (48) (48)
Angiectasis 2 (4%)
Dilatation 2 (4%) 5 (10%)
Hyperplasia, Lymphoid 1 (2%)
Inflammation, Chronic Active 2 (4%)
Endometrium, Hyperplasia, Cystic, Glandular 8 (17%) 11 (23%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 05076-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ETHYLENETHIOUREA Date: 09/10/94
Route: DOSED FEED Time: 02:00:00
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 1000 PPM 1000 PPM
0-10 10-10
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (49) (49)
Femoral, Hyperplasia, Neutrophil 1 (2%) 1 (2%)
Femoral, Hyperplasia, Reticulum Cell 1 (2%)
Lymph Node (47) (49)
Mandibular, Hyperplasia 1 (2%)
Mandibular, Hyperplasia, Lymphoid 4 (9%) 2 (4%)
Mediastinal, Hyperplasia, Lymphoid 1 (2%) 3 (6%)
Lymph Node, Mesenteric (4) (9)
Inflammation, Chronic Active 1 (25%)
Spleen (49) (50)
Hematopoietic Cell Proliferation 1 (2%)
Hyperplasia, Lymphoid 6 (12%) 2 (4%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (49) (50)
Acanthosis 17 (35%) 7 (14%)
Cyst Epithelial Inclusion 1 (2%)
Parasite External 22 (45%) 7 (14%)
Lip, Inflammation, Chronic 1 (2%)
Subcutaneous Tissue, Inflammation, Chronic
Active 2 (4%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50)
Compression 2 (4%) 2 (4%)
Hydrocephalus 2 (4%)
Perivascular, Inflammation, Chronic Active 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50)
Hyperplasia, Lymphoid 5 (10%) 2 (4%)
Alveolar Epithelium, Hyperplasia 1 (2%) 1 (2%)
Peribronchiolar, Inflammation, Chronic Active 9 (18%) 6 (12%)
Nose (49) (50)
Mucosa, Inflammation, Acute 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 05076-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ETHYLENETHIOUREA Date: 09/10/94
Route: DOSED FEED Time: 02:00:00
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE 1000 PPM 1000 PPM
0-10 10-10
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (1) (2)
Atrophy 1 (100%) 2 (100%)
Harderian Gland (4) (3)
Inflammation, Chronic Active 1 (25%)
Acinus, Dilatation 2 (50%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50)
Hyperplasia, Lymphoid 2 (4%)
Nephropathy, Chronic 1 (2%) 1 (2%)
Urinary Bladder (49) (49)
Hyperplasia, Lymphoid 4 (8%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 05076-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ETHYLENETHIOUREA Date: 09/10/94
Route: DOSED FEED Time: 02:00:00
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 0 PPM 100 PPM 333 PPM 333 PPM 333 PPM
0-0 10-0 1-1 0-3 3-3 10-3
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 34 50 50 50
Early Deaths
Moribund Sacrifice 8 7 5 8 10 5
Natural Death 11 10 2 10 8 13
Accidently Killed 5
Survivors
Moribund Sacrifice 1
Natural Death 1 1 1
Terminal Sacrifice 30 27 25 31 32 30
Missing 1 1 1
Animals Examined Microscopically 50 49 33 50 50 49
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (40) (12) (6) (10) (13) (11)
Inflammation, Chronic Active 1 (3%)
Intestine Large, Cecum (45) (19) (7) (17) (14) (13)
Inflammation, Acute 1 (7%)
Parasite Metazoan 1 (14%)
Intestine Large, Colon (50) (21) (8) (17) (16) (16)
Parasite Metazoan 5 (10%) 3 (18%) 1 (6%)
Intestine Large, Rectum (48) (19) (8) (17) (15) (16)
Parasite Metazoan 1 (7%)
Intestine Small, Ileum (44) (18) (7) (16) (14) (13)
Parasite Metazoan 1 (14%)
Intestine Small, Jejunum (45) (20) (10) (18) (16) (18)
Inflammation, Chronic Active 1 (2%)
Liver (49) (49) (33) (50) (47) (49)
Basophilic Focus 3 (6%) 5 (10%) 3 (9%) 5 (10%) 4 (9%) 3 (6%)
Clear Cell Focus 1 (2%) 1 (3%) 3 (6%) 1 (2%) 5 (10%)
Eosinophilic Focus 2 (4%) 8 (16%) 3 (6%) 3 (6%)
Fatty Change, Focal 1 (2%)
Fibrosis 1 (2%)
Hematopoietic Cell Proliferation 3 (6%) 1 (2%) 3 (6%) 4 (8%)
Infarct 14 (29%) 4 (8%) 2 (6%) 7 (14%) 3 (6%) 2 (4%)
Inflammation, Chronic Active 5 (10%) 1 (2%) 1 (2%)
Mixed Cell Focus 2 (4%)
Necrosis 2 (4%)
Bile Duct, Cyst 3 (6%) 2 (4%)
Bile Duct, Hyperplasia 2 (4%)
Central Vein, Thrombosis 1 (2%) 1 (2%)
Centrilobular, Cytomegaly 1 (2%) 6 (18%) 36 (72%) 33 (70%) 29 (59%)
Centrilobular, Necrosis 1 (2%)
Centrilobular, Necrosis, Acute 1 (3%) 2 (4%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 05076-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ETHYLENETHIOUREA Date: 09/10/94
Route: DOSED FEED Time: 02:00:00
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 0 PPM 100 PPM 333 PPM 333 PPM 333 PPM
0-0 10-0 1-1 0-3 3-3 10-3
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Mesentery (6) (1) (1) (1)
Angiectasis 1 (17%)
Inflammation, Chronic Active 2 (33%) 1 (100%)
Pancreas (48) (20) (7) (17) (15) (17)
Inflammation, Chronic Active 1 (7%)
Acinus, Atrophy 5 (10%) 1 (7%)
Acinus, Focal Cellular Change 1 (2%)
Acinus, Inflammation, Chronic Active 1 (6%) 1 (6%)
Duct, Cyst 1 (2%) 1 (6%)
Salivary Glands (50) (21) (8) (19) (15) (17)
Inflammation, Acute 1 (2%)
Acinus, Atrophy 1 (2%)
Stomach, Forestomach (49) (24) (7) (17) (16) (22)
Acanthosis 1 (2%) 1 (4%) 1 (6%) 1 (5%)
Cyst Epithelial Inclusion 1 (5%)
Inflammation, Acute 1 (2%)
Ulcer 1 (5%)
Stomach, Glandular (48) (21) (7) (17) (15) (18)
Infiltration Cellular, Lymphocyte 1 (14%)
Tooth (5)
Incisor, Upper, Dysplasia 3 (60%)
Peridontal Tissue, Infiltration Cellular,
Mast Cell 1 (20%)
Peridontal Tissue, Inflammation, Suppurative 1 (20%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (23) (8) (19) (15) (19)
Bacterium, Acute, Multiple 1 (2%)
Degeneration, Chronic 1 (13%)
Mineralization 1 (2%)
Thrombosis 1 (4%)
Valve, Inflammation, Suppurative 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland (50) (21) (8) (18) (15) (18)
Corticomedullary Junction, Cyst 1 (2%)
Adrenal Gland, Cortex (50) (21) (8) (18) (15) (18)
Hyperplasia 6 (12%) 1 (6%)
Hypertrophy 8 (16%) 1 (13%) 1 (6%)
Adrenal Gland, Medulla (50) (21) (8) (18) (15) (18)
Hyperplasia 3 (6%)
Pituitary Gland (44) (42) (28) (42) (41) (45)
Ectasia 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 12
NTP Experiment-Test: 05076-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ETHYLENETHIOUREA Date: 09/10/94
Route: DOSED FEED Time: 02:00:00
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 0 PPM 100 PPM 333 PPM 333 PPM 333 PPM
0-0 10-0 1-1 0-3 3-3 10-3
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Craniopharyngeal Duct, Inflammation, Chronic
Active 1 (2%)
Pars Distalis, Cyst 2 (5%) 1 (4%) 1 (2%) 1 (2%)
Pars Distalis, Hyperplasia 1 (4%) 2 (5%) 2 (5%) 1 (2%)
Thyroid Gland (50) (46) (33) (49) (47) (48)
Artery, Inflammation, Chronic Active 1 (2%)
Follicular Cell, Hyperplasia 2 (4%) 1 (3%) 3 (6%) 7 (15%)
Follicular Cell, Vacuolization Cytoplasmic 25 (76%) 46 (94%) 43 (91%) 46 (96%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (49) (22) (8) (18) (15) (19)
Inflammation, Acute 1 (6%)
Inflammation, Chronic Active 2 (11%)
Preputial Gland (2) (2) (1) (2) (4) (3)
Inflammation, Chronic Active 1 (50%) 1 (100%) 2 (100%) 2 (50%) 2 (67%)
Inflammation, Suppurative 1 (50%) 1 (50%)
Duct, Dilatation 1 (50%) 2 (100%) 2 (50%) 2 (67%)
Prostate (50) (22) (8) (18) (15) (19)
Inflammation, Chronic Active 2 (11%) 1 (7%) 3 (16%)
Inflammation, Suppurative 3 (6%) 3 (14%) 2 (11%)
Seminal Vesicle (4) (2) (1) (1) (1)
Dilatation 2 (50%) 2 (100%) 1 (100%) 1 (100%) 1 (100%)
Inflammation, Suppurative 1 (25%)
Testes (50) (22) (8) (20) (14) (19)
Seminiferous Tubule, Degeneration 1 (2%) 1 (5%) 2 (10%)
Seminiferous Tubule, Mineralization 1 (5%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (49) (21) (8) (18) (13) (19)
Femoral, Hyperplasia, Neutrophil 1 (2%) 1 (5%) 1 (6%) 2 (11%)
Lymph Node (48) (25) (15) (22) (20) (22)
Lumbar, Hyperplasia, Lymphoid 1 (4%)
Mandibular, Hyperplasia, Lymphoid 2 (9%) 1 (5%)
Mandibular, Infiltration Cellular, Histiocyte 1 (4%) 1 (7%)
Lymph Node, Mesenteric (14) (11) (7) (4) (8) (6)
Hematopoietic Cell Proliferation 11 (79%) 7 (64%) 1 (14%) 2 (50%) 3 (38%)
Hemorrhage 1 (17%)
Hyperplasia, Lymphoid 2 (18%) 1 (14%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 13
NTP Experiment-Test: 05076-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ETHYLENETHIOUREA Date: 09/10/94
Route: DOSED FEED Time: 02:00:00
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 0 PPM 100 PPM 333 PPM 333 PPM 333 PPM
0-0 10-0 1-1 0-3 3-3 10-3
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Infiltration Cellular, Plasma Cell 1 (14%)
Inflammation, Chronic Active 1 (13%) 1 (17%)
Thrombosis 1 (7%)
Spleen (49) (25) (12) (21) (24) (24)
Depletion Lymphoid 4 (8%) 1 (4%) 2 (8%)
Hematopoietic Cell Proliferation 3 (6%) 2 (8%) 2 (17%) 4 (19%) 5 (21%) 8 (33%)
Hyperplasia, Lymphoid 1 (4%) 1 (5%) 1 (4%) 1 (4%)
Thymus (29) (11) (4) (11) (11) (11)
Depletion Lymphoid 1 (9%) 1 (9%) 2 (18%) 1 (9%)
Necrosis, Diffuse 1 (3%) 1 (9%) 1 (9%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (50) (26) (14) (23) (25) (26)
Acanthosis 3 (12%) 4 (29%) 4 (17%) 3 (12%) 2 (8%)
Alopecia 1 (7%)
Hyperplasia, Basal Cell 1 (7%)
Parasite External 1 (2%) 4 (15%) 6 (43%) 5 (22%) 4 (16%) 5 (19%)
Ulcer 1 (2%) 3 (12%) 3 (13%) 5 (20%) 3 (12%)
Prepuce, Inflammation, Acute 1 (4%)
Prepuce, Subcutaneous Tissue, Foreign Body 1 (4%)
Subcutaneous Tissue, Edema 1 (4%)
Subcutaneous Tissue, Fibrosis 1 (2%) 1 (4%) 1 (7%) 2 (9%) 1 (4%) 1 (4%)
Subcutaneous Tissue, Granuloma 1 (7%)
Subcutaneous Tissue, Inflammation, Acute 1 (2%) 1 (4%)
Subcutaneous Tissue, Inflammation, Chronic
Active 2 (8%) 1 (4%) 2 (8%)
Subcutaneous Tissue, Metaplasia, Osseous 1 (4%)
Subcutaneous Tissue, Sebaceous Gland,
Hyperplasia 1 (4%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (44) (25) (42) (39) (38)
Femur, Hyperostosis 1 (2%)
Tarsal, Hyperostosis 22 (44%) 24 (55%) 18 (72%) 28 (67%) 29 (74%) 29 (76%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (21) (8) (19) (15) (19)
Infarct 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 14
NTP Experiment-Test: 05076-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ETHYLENETHIOUREA Date: 09/10/94
Route: DOSED FEED Time: 02:00:00
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 0 PPM 100 PPM 333 PPM 333 PPM 333 PPM
0-0 10-0 1-1 0-3 3-3 10-3
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (49) (33) (50) (47) (49)
Inflammation, Chronic, Diffuse 1 (2%)
Metaplasia, Squamous 1 (2%)
Alveolar Epithelium, Hyperplasia 2 (4%) 2 (4%) 3 (9%) 2 (4%) 5 (11%) 3 (6%)
Alveolus, Hyperplasia, Macrophage 1 (2%) 1 (2%)
Artery, Embolus 1 (2%)
Mediastinum, Inflammation 1 (3%)
Peribronchial, Inflammation, Chronic Active 2 (4%) 1 (2%)
Peribronchiolar, Inflammation, Chronic Active 26 (52%) 6 (12%) 5 (15%) 17 (34%) 16 (34%) 7 (14%)
Perivascular, Inflammation, Chronic Active 2 (4%) 1 (2%)
Nose (50) (21) (8) (19) (16) (18)
Mucosa, Inflammation, Acute 2 (4%) 1 (6%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (2) (1)
Atrophy 1 (100%)
Cornea, Inflammation, Chronic Active 1 (50%)
Harderian Gland (4) (1) (3) (3) (1) (3)
Hyperplasia 1 (25%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (49) (23) (11) (21) (17) (19)
Hydronephrosis 1 (2%) 2 (9%)
Inflammation, Chronic Active 1 (4%)
Metaplasia, Osseous 1 (2%)
Nephropathy, Chronic 32 (65%) 3 (13%) 3 (14%) 2 (11%)
Capsule, Fibrosis, Focal 1 (4%) 1 (9%)
Cortex, Cyst 2 (18%) 1 (6%)
Cortex, Infiltration Cellular, Focal,
Histiocyte 1 (6%)
Pelvis, Bacterium 1 (2%)
Pelvis, Inflammation, Suppurative 2 (4%) 1 (5%)
Renal Tubule, Mineralization 1 (5%)
Renal Tubule, Necrosis 1 (2%) 1 (4%)
Urethra (2) (2) (1)
Inflammation, Chronic Active 1 (100%)
Inflammation, Suppurative 2 (100%) 1 (50%)
Bulbourethral Gland, Dilatation 1 (50%)
Urinary Bladder (49) (20) (8) (17) (15) (16)
Calculus Gross Observation 2 (10%)
Dilatation 2 (4%) 3 (15%) 2 (25%) 2 (12%) 2 (13%)
Inflammation, Chronic Active 3 (6%) 2 (10%) 1 (6%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 15
NTP Experiment-Test: 05076-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ETHYLENETHIOUREA Date: 09/10/94
Route: DOSED FEED Time: 02:00:00
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 0 PPM 0 PPM 100 PPM 333 PPM 333 PPM 333 PPM
0-0 10-0 1-1 0-3 3-3 10-3
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Mineralization 2 (4%)
Mucosa, Hyperplasia 1 (6%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 16
NTP Experiment-Test: 05076-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ETHYLENETHIOUREA Date: 09/10/94
Route: DOSED FEED Time: 02:00:00
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 1000 PPM 1000 PPM
0-10 10-10
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50
Early Deaths
Moribund Sacrifice 14 10
Natural Death 13 15
Survivors
Terminal Sacrifice 22 24
Natural Death 1 1
Animals Examined Microscopically 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (33) (27)
Epithelium, Hypertrophy, Focal 1 (4%)
Intestine Large, Cecum (42) (40)
Parasite Metazoan 3 (8%)
Intestine Large, Colon (49) (45)
Inflammation, Acute, Necrotizing 1 (2%)
Parasite Metazoan 8 (16%) 9 (20%)
Intestine Large, Rectum (46) (41)
Parasite Metazoan 4 (9%) 4 (10%)
Intestine Small, Ileum (43) (40)
Parasite Metazoan 4 (9%) 1 (3%)
Intestine Small, Jejunum (44) (40)
Inflammation, Chronic Active 1 (2%)
Lymphatic, Ectasia 1 (3%)
Liver (50) (49)
Basophilic Focus 1 (2%)
Eosinophilic Focus 2 (4%) 11 (22%)
Hematopoietic Cell Proliferation 1 (2%)
Infarct 33 (66%) 34 (69%)
Centrilobular, Cytomegaly 25 (50%) 40 (82%)
Oval Cell, Hyperplasia 2 (4%)
Mesentery (5) (3)
Angiectasis 1 (20%)
Inflammation, Acute, Necrotizing 1 (20%)
Inflammation, Chronic Active 1 (20%)
Pancreas (45) (47)
Acinus, Atrophy 4 (9%) 2 (4%)
Duct, Ectasia 1 (2%)
Perivascular, Inflammation, Chronic Active 1 (2%)
Salivary Glands (50) (49)
Acinus, Atrophy 1 (2%)
Perivascular, Inflammation, Suppurative 1 (2%)
Stomach, Forestomach (49) (45)
a Number of animals examined microscopically at site and number of animals with lesion
Page 17
NTP Experiment-Test: 05076-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ETHYLENETHIOUREA Date: 09/10/94
Route: DOSED FEED Time: 02:00:00
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 1000 PPM 1000 PPM
0-10 10-10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Acanthosis 1 (2%)
Inflammation, Acute 1 (2%)
Stomach, Glandular (48) (44)
Dysplasia 1 (2%)
Infiltration Cellular, Mast Cell 1 (2%)
Inflammation, Acute 1 (2%)
Inflammation, Chronic 2 (4%)
Tooth (4) (1)
Incisor, Upper, Dysplasia 1 (25%)
Peridontal Tissue, Inflammation, Suppurative 2 (50%) 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50)
Bacterium, Acute, Multiple 1 (2%)
Degeneration, Chronic 1 (2%)
Mineralization 1 (2%)
Thrombosis 1 (2%)
Artery, Inflammation, Chronic Active 1 (2%)
Valve, Bacterium 1 (2%)
Valve, Inflammation, Suppurative 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (50) (49)
Hyperplasia 3 (6%) 3 (6%)
Hypertrophy 10 (20%) 7 (14%)
Adrenal Gland, Medulla (50) (49)
Hyperplasia 2 (4%) 4 (8%)
Pituitary Gland (41) (39)
Pars Distalis, Hyperplasia 32 (78%) 25 (64%)
Thyroid Gland (50) (49)
Follicular Cell, Hyperplasia 44 (88%) 47 (96%)
Follicular Cell, Vacuolization Cytoplasmic 47 (94%) 46 (94%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 18
NTP Experiment-Test: 05076-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ETHYLENETHIOUREA Date: 09/10/94
Route: DOSED FEED Time: 02:00:00
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 1000 PPM 1000 PPM
0-10 10-10
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (49) (49)
Inflammation, Chronic Active 1 (2%)
Arteriole, Inflammation, Chronic Active 1 (2%)
Preputial Gland (2) (1)
Inflammation, Chronic Active 1 (50%)
Inflammation, Suppurative 1 (50%)
Duct, Dilatation 1 (50%) 1 (100%)
Prostate (47) (49)
Inflammation, Suppurative 1 (2%) 2 (4%)
Arteriole, Inflammation, Chronic Active 1 (2%)
Seminal Vesicle (2)
Dilatation 1 (50%)
Testes (50) (49)
Arteriole, Inflammation, Chronic Active 1 (2%)
Seminiferous Tubule, Degeneration 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (49) (47)
Femoral, Hyperplasia, Neutrophil 1 (2%)
Lymph Node (47) (48)
Lumbar, Necrosis 1 (2%)
Pancreatic, Necrosis 1 (2%)
Lymph Node, Mesenteric (7) (5)
Hematopoietic Cell Proliferation 3 (43%) 2 (40%)
Spleen (48) (47)
Hematopoietic Cell Proliferation 3 (6%) 1 (2%)
Thymus (16) (16)
Necrosis, Diffuse 2 (13%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (49) (50)
Acanthosis 1 (2%)
Parasite External 28 (57%) 6 (12%)
Subcutaneous Tissue, Edema 1 (2%)
Subcutaneous Tissue, Fibrosis 1 (2%) 1 (2%)
Subcutaneous Tissue, Inflammation, Chronic
Active 5 (10%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 19
NTP Experiment-Test: 05076-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ETHYLENETHIOUREA Date: 09/10/94
Route: DOSED FEED Time: 02:00:00
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 1000 PPM 1000 PPM
0-10 10-10
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50)
Tarsal, Hyperostosis 15 (30%) 24 (48%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (49)
Infarct 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (49)
Inflammation, Chronic, Diffuse 1 (2%)
Alveolar Epithelium, Hyperplasia 2 (4%) 4 (8%)
Alveolus, Hyperplasia, Macrophage 1 (2%)
Arteriole, Capillary, Inflammation,
Suppurative 1 (2%)
Artery, Mediastinum, Inflammation,
Suppurative 1 (2%)
Peribronchiolar, Inflammation, Acute,
Necrotizing 1 (2%)
Peribronchiolar, Inflammation, Chronic Active 21 (42%) 18 (37%)
Perivascular, Inflammation, Chronic Active 1 (2%)
Nose (50) (49)
Mucosa, Inflammation, Acute 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (6) (2)
Atrophy 5 (83%) 2 (100%)
Inflammation 1 (17%)
Inflammation, Suppurative 1 (17%)
Harderian Gland (18) (6)
Inflammation, Chronic Active 10 (56%) 2 (33%)
Inflammation, Suppurative 5 (28%) 1 (17%)
Necrosis 1 (17%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (49)
Infarct 1 (2%)
Nephropathy, Chronic 22 (44%) 17 (35%)
Pelvis, Inflammation, Suppurative 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 20
NTP Experiment-Test: 05076-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ETHYLENETHIOUREA Date: 09/10/94
Route: DOSED FEED Time: 02:00:00
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE 1000 PPM 1000 PPM
0-10 10-10
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Renal Tubule, Necrosis 1 (2%) 1 (2%)
Urethra (3) (1)
Inflammation, Suppurative 3 (100%) 1 (100%)
Urinary Bladder (48) (48)
Inflammation, Chronic Active 1 (2%)
Arteriole, Inflammation, Chronic Active 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 21
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