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TR 388 Mouse Pathology Tables


                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                          ETHYLENETHIOUREA


NTP Experiment-Test: 05076-02                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 09/10/94
Route: DOSED FEED                                                                                                 Time: 02:00:01




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  96-45-7

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05076-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 09/10/94  
Route: DOSED FEED                                                                                                 Time: 02:00:01  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 PPM        0 PPM        100 PPM      333 PPM      333 PPM      333 PPM         
                                                   0-0          10-0           1-1          0-3          3-3          10-3          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           50           29           50           50           50           
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 9            4            6            6           11            9           
    Natural Death                                      6            8            2            1            3            5           
  Survivors                                                                                                                         
    Terminal Sacrifice                                34           37           21           42           34           36           
    Natural Death                                      1            1                         1            2                        
  Animals Examined Microscopically                    50           50           29           50           50           50           
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (49)         (13)         (8)          (8)          (16)         (14)         
      Squamous Cell Carcinoma                          1 (2%)                                                                       
   Gallbladder                                        (41)         (7)          (8)          (7)          (12)         (8)          
   Intestine Large, Cecum                             (44)         (10)         (8)          (7)          (14)         (11)         
      Leiomyosarcoma                                   1 (2%)                                                                       
   Intestine Large, Colon                             (49)         (12)         (8)          (9)          (16)         (12)         
      Leiomyosarcoma                                                                          1 (11%)                               
   Intestine Small, Jejunum                           (46)         (12)         (10)         (8)          (19)         (13)         
   Liver                                              (50)         (49)         (28)         (50)         (50)         (50)         
      Carcinoma, Metastatic, Islets, Pancreatic                     1 (2%)                                                          
      Fibrosarcoma, Metastatic, Skin                   1 (2%)                                                                       
      Hemangioma                                                    1 (2%)                                                          
      Hemangiosarcoma                                               1 (2%)                    4 (8%)       2 (4%)       1 (2%)      
      Hemangiosarcoma, Multiple                        1 (2%)                                              1 (2%)                   
      Hepatoblastoma                                                                                       1 (2%)       1 (2%)      
      Hepatocellular Carcinoma                         2 (4%)       5 (10%)      2 (7%)      14 (28%)     11 (22%)      9 (18%)     
      Hepatocellular Carcinoma, Multiple                                                     15 (30%)     20 (40%)     14 (28%)     
      Hepatocellular Adenoma                           2 (4%)       1 (2%)       2 (7%)      19 (38%)     17 (34%)     14 (28%)     
      Hepatocellular Adenoma, Multiple                                                       14 (28%)     17 (34%)     21 (42%)     
      Histiocytic Sarcoma, Single                                                1 (4%)       2 (4%)       1 (2%)       2 (4%)      
   Mesentery                                          (6)          (2)                       (1)          (1)          (1)          
      Fibrosarcoma, Metastatic, Skin                                                                                    1 (100%)    
      Hemangiosarcoma                                  1 (17%)                                                                      
      Lipoma                                           1 (17%)                                                                      
   Pancreas                                           (50)         (11)         (8)          (7)          (16)         (13)         
   Salivary Glands                                    (50)         (13)         (8)          (8)          (15)         (14)         
   Stomach, Forestomach                               (48)         (15)         (10)         (11)         (17)         (14)         
      Squamous Cell Papilloma                          1 (2%)       1 (7%)                    1 (9%)       1 (6%)                   
   Stomach, Glandular                                 (48)         (11)         (8)          (8)          (15)         (13)         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   2                                                               
NTP Experiment-Test: 05076-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 09/10/94  
Route: DOSED FEED                                                                                                 Time: 02:00:01  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 PPM        0 PPM        100 PPM      333 PPM      333 PPM      333 PPM         
                                                   0-0          10-0           1-1          0-3          3-3          10-3          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (13)         (8)          (8)          (16)         (14)         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (49)         (13)         (8)          (8)          (16)         (12)         
      Capsule, Adenoma                                                                                     1 (6%)                   
   Adrenal Gland, Cortex                              (49)         (13)         (8)          (8)          (16)         (11)         
   Adrenal Gland, Medulla                             (48)         (13)         (8)          (8)          (16)         (11)         
      Pheochromocytoma Benign                          1 (2%)                                                                       
   Islets, Pancreatic                                 (49)         (13)         (8)          (7)          (15)         (12)         
      Carcinoma                                                     1 (8%)                                                          
   Pituitary Gland                                    (47)         (48)         (28)         (49)         (48)         (47)         
      Pars Distalis, Adenoma                          10 (21%)     11 (23%)      6 (21%)     19 (39%)     14 (29%)     26 (55%)     
      Pars Distalis, Carcinoma                         1 (2%)                    1 (4%)                                             
      Pars Intermedia, Adenoma                                                   2 (7%)                    1 (2%)       1 (2%)      
   Thyroid Gland                                      (50)         (49)         (29)         (50)         (50)         (49)         
      Follicular Cell, Adenoma                                      1 (2%)       1 (3%)       1 (2%)       3 (6%)       1 (2%)      
      Follicular Cell, Adenoma, Multiple                                                      1 (2%)       2 (4%)       9 (18%)     
      Follicular Cell, Carcinoma                                                                                        1 (2%)      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (49)         (26)         (20)         (15)         (24)         (25)         
      Cystadenoma                                      1 (2%)                                                                       
      Cystadenoma, Papillary                                                                  1 (7%)                    2 (8%)      
      Hemangioma                                                    1 (4%)                                                          
      Luteoma                                                       1 (4%)                                                          
   Uterus                                             (48)         (33)         (13)         (19)         (20)         (20)         
      Hemangiosarcoma                                                                                      1 (5%)                   
      Histiocytic Sarcoma, Single                                                                                       1 (5%)      
      Leiomyosarcoma                                                                          1 (5%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (49)         (13)         (8)          (8)          (16)         (13)         
      Femoral, Hemangiosarcoma                         1 (2%)                                                                       
      Femoral, Histiocytic Sarcoma, Single                                       1 (13%)      1 (13%)                               
   Lymph Node                                         (49)         (18)         (15)         (19)         (25)         (19)         
                                                             Page   3                                                               
NTP Experiment-Test: 05076-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 09/10/94  
Route: DOSED FEED                                                                                                 Time: 02:00:01  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 PPM        0 PPM        100 PPM      333 PPM      333 PPM      333 PPM         
                                                   0-0          10-0           1-1          0-3          3-3          10-3          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - cont                                                                                                         
      Mandibular, Hemangiosarcoma, Metastatic,                                                                                      
           Liver                                                                                           1 (4%)                   
      Mandibular, Histiocytic Sarcoma, Single                                    1 (7%)       2 (11%)                   1 (5%)      
      Mandibular, Sarcoma, Metastatic, Uncertain                                                                                    
          Primary Site                                                                        1 (5%)                                
      Pancreatic, Leiomyosarcoma, Metastatic,                                                                                       
          Intestine Large                                                                     1 (5%)                                
   Lymph Node, Mesenteric                             (14)         (10)         (8)          (12)         (14)         (9)          
      Histiocytic Sarcoma, Single                                                1 (13%)      1 (8%)                    1 (11%)     
   Lymph Node, Thoracic                               (2)                                                                           
   Spleen                                             (50)         (23)         (13)         (28)         (31)         (34)         
      Hemangiosarcoma                                  1 (2%)       1 (4%)                    3 (11%)      1 (3%)       1 (3%)      
      Histiocytic Sarcoma, Single                                                1 (8%)       1 (4%)                    2 (6%)      
   Thymus                                             (39)         (7)          (4)          (6)          (12)         (5)          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (35)         (13)         (8)          (8)          (16)         (11)         
      Adenocarcinoma                                   1 (3%)                    1 (13%)      2 (25%)      2 (13%)      3 (27%)     
      Fibroadenoma                                     1 (3%)       1 (8%)                                                          
   Skin                                               (50)         (13)         (8)          (8)          (16)         (15)         
      Subcutaneous Tissue, Fibrosarcoma                1 (2%)       1 (8%)                                              1 (7%)      
      Subcutaneous Tissue, Hemangiosarcoma             1 (2%)       1 (8%)                                                          
      Subcutaneous Tissue, Sarcoma                                                                                      1 (7%)      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (13)         (9)          (9)          (16)         (14)         
      Cranium, Osteosarcoma                            1 (2%)       1 (8%)                                                          
      Lumbar, Osteosarcoma                                                                                              1 (7%)      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (13)         (8)          (8)          (16)         (14)         
      Carcinoma, Metastatic, Pituitary Gland           1 (2%)                                                                       
      Histiocytic Sarcoma, Single                                                             1 (13%)                   1 (7%)      
      Osteosarcoma, Metastatic, Bone                                1 (8%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   4                                                               
NTP Experiment-Test: 05076-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 09/10/94  
Route: DOSED FEED                                                                                                 Time: 02:00:01  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 PPM        0 PPM        100 PPM      333 PPM      333 PPM      333 PPM         
                                                   0-0          10-0           1-1          0-3          3-3          10-3          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (29)         (50)         (50)         (50)         
      Adenocarcinoma, Metastatic, Harderian Gland                                1 (3%)                                             
      Alveolar/Bronchiolar Adenoma                     2 (4%)       3 (6%)       1 (3%)       7 (14%)      2 (4%)       5 (10%)     
      Alveolar/Bronchiolar Adenoma, Multiple                                                                            1 (2%)      
      Alveolar/Bronchiolar Carcinoma                   3 (6%)       2 (4%)                    1 (2%)       1 (2%)       2 (4%)      
      Fibrosarcoma, Metastatic, Skin                                                                                    1 (2%)      
      Hepatocellular Carcinoma, Metastatic, Liver                                             1 (2%)                                
      Histiocytic Sarcoma, Single                                                1 (3%)       2 (4%)       1 (2%)       2 (4%)      
      Osteosarcoma, Metastatic, Bone                                1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (3)          (3)          (1)          (4)          (1)          (1)          
      Adenocarcinoma                                                1 (33%)      1 (100%)     2 (50%)                               
      Adenoma                                          2 (67%)      2 (67%)                   1 (25%)      1 (100%)     1 (100%)    
      Bilateral, Adenoma                                                                      1 (25%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (12)         (8)          (11)         (16)         (15)         
      Histiocytic Sarcoma, Single                                                             1 (9%)                                
      Renal Tubule, Adenoma, Multiple                  1 (2%)                                                                       
   Urinary Bladder                                    (48)         (12)         (8)          (9)          (13)         (11)         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(29)        *(50)        *(50)        *(50)         
      Histiocytic Sarcoma                                                        1 (3%)       2 (4%)       1 (2%)       2 (4%)      
      Lymphoma Malignant                                                                      1 (2%)       1 (2%)                   
      Lymphoma Malignant Histiocytic                   1 (2%)       1 (2%)       1 (3%)       1 (2%)                                
      Lymphoma Malignant Lymphocytic                   5 (10%)      2 (4%)       2 (7%)       2 (4%)       6 (12%)      3 (6%)      
      Lymphoma Malignant Mixed                        14 (28%)     11 (22%)      5 (17%)     10 (20%)     17 (34%)      7 (14%)     
      Lymphoma Malignant Undifferentiated Cell         1 (2%)       2 (4%)                                 2 (4%)       3 (6%)      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   5                                                               
NTP Experiment-Test: 05076-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 09/10/94  
Route: DOSED FEED                                                                                                 Time: 02:00:01  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        0 PPM        0 PPM        100 PPM      333 PPM      333 PPM      333 PPM         
                                                   0-0          10-0           1-1          0-3          3-3          10-3          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            36          33          20          49          49          50               
     Total Primary Neoplasms                           59          53          26         124         126         131               
                                                                                                                                    
   Total Animals with Benign Neoplasms                 17          19           9          42          40          44               
     Total Benign Neoplasms                            22          23          12          65          59          81               
                                                                                                                                    
   Total Animals with Malignant Neoplasms              30          25          13          44          44          38               
     Total Malignant Neoplasms                         37          30          14          59          67          50               
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              2           2           1           3           1           1               
     Total Metastatic Neoplasm                          2           3           1           3           1           2               
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                   1                                       
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   6                                                               
NTP Experiment-Test: 05076-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 09/10/94  
Route: DOSED FEED                                                                                                 Time: 02:00:01  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        1000 PPM     1000 PPM                                                            
                                                      0-10         10-10                                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           50                                                               
  Early Deaths                                                                                                                      
    Natural Death                                      9            7                                                               
    Moribund Sacrifice                                10           14                                                               
  Survivors                                                                                                                         
    Natural Death                                      1                                                                            
    Terminal Sacrifice                                30           29                                                               
  Animals Examined Microscopically                    50           50                                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (39)         (39)                                                             
   Intestine Small, Jejunum                           (50)         (48)                                                             
   Liver                                              (50)         (50)                                                             
      Hemangiosarcoma                                  2 (4%)                                                                       
      Hepatoblastoma                                   2 (4%)       8 (16%)                                                         
      Hepatoblastoma, Multiple                                      1 (2%)                                                          
      Hepatocellular Carcinoma                         3 (6%)       3 (6%)                                                          
      Hepatocellular Carcinoma, Multiple              44 (88%)     45 (90%)                                                         
      Hepatocellular Adenoma                          11 (22%)     10 (20%)                                                         
      Hepatocellular Adenoma, Multiple                 3 (6%)       7 (14%)                                                         
      Histiocytic Sarcoma, Single                      1 (2%)       2 (4%)                                                          
   Mesentery                                          (2)          (1)                                                              
   Pancreas                                           (50)         (50)                                                             
   Salivary Glands                                    (49)         (50)                                                             
      Histiocytic Sarcoma, Single                                   1 (2%)                                                          
   Stomach, Forestomach                               (49)         (50)                                                             
   Stomach, Glandular                                 (49)         (50)                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (49)         (50)                                                             
      Histiocytic Sarcoma, Single                      1 (2%)                                                                       
   Adrenal Gland, Medulla                             (50)         (50)                                                             
      Pheochromocytoma Benign                          1 (2%)       1 (2%)                                                          
   Pituitary Gland                                    (49)         (47)                                                             
      Pars Distalis, Adenoma                          26 (53%)     24 (51%)                                                         
                                                             Page   7                                                               
NTP Experiment-Test: 05076-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 09/10/94  
Route: DOSED FEED                                                                                                 Time: 02:00:01  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        1000 PPM     1000 PPM                                                            
                                                      0-10         10-10                                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - cont                                                                                                             
   Thyroid Gland                                      (50)         (50)                                                             
      Follicular Cell, Adenoma                         4 (8%)      12 (24%)                                                         
      Follicular Cell, Adenoma, Multiple              31 (62%)     26 (52%)                                                         
      Follicular Cell, Carcinoma                       8 (16%)      4 (8%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                         (1)                                                                           
      Hepatocellular Carcinoma, Metastatic, Liver      1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (50)         (48)                                                             
      Cystadenoma                                      2 (4%)                                                                       
      Cystadenoma, Papillary                                        1 (2%)                                                          
      Granulosa Cell Tumor Benign                      1 (2%)                                                                       
      Yolk Sac Carcinoma                                            1 (2%)                                                          
   Uterus                                             (48)         (48)                                                             
      Histiocytic Sarcoma, Single                      1 (2%)                                                                       
      Polyp Stromal                                                 1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (49)         (49)                                                             
      Femoral, Histiocytic Sarcoma, Single             1 (2%)                                                                       
   Lymph Node                                         (47)         (49)                                                             
      Mandibular, Histiocytic Sarcoma, Single          1 (2%)       2 (4%)                                                          
      Mediastinal, Histiocytic Sarcoma, Single                      2 (4%)                                                          
      Renal, Histiocytic Sarcoma, Single                            1 (2%)                                                          
   Lymph Node, Mesenteric                             (4)          (9)                                                              
      Hepatocellular Carcinoma, Metastatic, Liver                   1 (11%)                                                         
      Histiocytic Sarcoma, Single                                   2 (22%)                                                         
   Spleen                                             (49)         (50)                                                             
      Hemangiosarcoma                                  1 (2%)       1 (2%)                                                          
      Histiocytic Sarcoma, Single                      1 (2%)       2 (4%)                                                          
   Thymus                                             (23)         (33)                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (33)         (37)                                                             
      Adenocarcinoma                                                1 (3%)                                                          
      Fibroadenoma                                                  1 (3%)                                                          
   Skin                                               (49)         (50)                                                             
                                                             Page   8                                                               
NTP Experiment-Test: 05076-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 09/10/94  
Route: DOSED FEED                                                                                                 Time: 02:00:01  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        1000 PPM     1000 PPM                                                            
                                                      0-10         10-10                                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - cont                                                                                                         
      Squamous Cell Papilloma                          1 (2%)                                                                       
      Subcutaneous Tissue, Fibrosarcoma                             1 (2%)                                                          
      Subcutaneous Tissue, Mast Cell Tumor Benign      1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)                                                             
      Alveolar/Bronchiolar Adenoma                                  4 (8%)                                                          
      Alveolar/Bronchiolar Carcinoma                                1 (2%)                                                          
      Carcinoma, Metastatic, Thyroid Gland             1 (2%)                                                                       
      Carcinoma, Metastatic, Uncertain Primary Site    1 (2%)                                                                       
      Hepatoblastoma, Metastatic, Liver                             4 (8%)                                                          
      Hepatocellular Carcinoma, Multiple,                                                                                           
          Metastatic, Liver                                         1 (2%)                                                          
      Hepatocellular Carcinoma, Metastatic, Liver      7 (14%)      5 (10%)                                                         
      Histiocytic Sarcoma, Single                      1 (2%)       2 (4%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (4)          (3)                                                              
      Adenocarcinoma                                                1 (33%)                                                         
      Adenoma                                          1 (25%)      1 (33%)                                                         
      Histiocytic Sarcoma, Single                                   1 (33%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)                                                             
      Renal Tubule, Adenocarcinoma                                  1 (2%)                                                          
   Urinary Bladder                                    (49)         (49)                                                             
                                                             Page   9                                                               
NTP Experiment-Test: 05076-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 09/10/94  
Route: DOSED FEED                                                                                                 Time: 02:00:01  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        1000 PPM     1000 PPM                                                            
                                                      0-10         10-10                                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)                                                             
      Histiocytic Sarcoma                              2 (4%)       2 (4%)                                                          
      Lymphoma Malignant Histiocytic                                1 (2%)                                                          
      Lymphoma Malignant Lymphocytic                   6 (12%)      5 (10%)                                                         
      Lymphoma Malignant Mixed                         5 (10%)      8 (16%)                                                         
      Lymphoma Malignant Undifferentiated Cell         3 (6%)       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  10                                                               
NTP Experiment-Test: 05076-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 09/10/94  
Route: DOSED FEED                                                                                                 Time: 02:00:01  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        1000 PPM     1000 PPM                                                            
                                                      0-10         10-10                                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            48          50                                                               
     Total Primary Neoplasms                          158         173                                                               
                                                                                                                                    
   Total Animals with Benign Neoplasms                 41          43                                                               
     Total Benign Neoplasms                            82          88                                                               
                                                                                                                                    
   Total Animals with Malignant Neoplasms              48          50                                                               
     Total Malignant Neoplasms                         76          85                                                               
                                                                                                                                    
   Total Animals with Metastatic Neoplasms             10           9                                                               
     Total Metastatic Neoplasm                         10          11                                                               
                                                                                                                                    
   Total Animals with Malignant Neoplasms               1                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  11                                                               
NTP Experiment-Test: 05076-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 09/10/94  
Route: DOSED FEED                                                                                                 Time: 02:00:01  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 PPM        0 PPM        100 PPM      333 PPM      333 PPM      333 PPM         
                                                   0-0          10-0           1-1          0-3          3-3          10-3          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           50           34           50           50           50           
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                 8            7            5            8           10            5           
    Natural Death                                     11           10            2           10            8           13           
    Accidently Killed                                               5                                                               
  Survivors                                                                                                                         
    Moribund Sacrifice                                                                                                  1           
    Natural Death                                      1                         1            1                                     
    Terminal Sacrifice                                30           27           25           31           32           30           
  Missing                                                           1            1                                      1           
  Animals Examined Microscopically                    50           49           33           50           50           49           
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (50)         (22)         (8)          (18)         (15)         (19)         
      Periesophageal Tissue, Sarcoma, Metastatic,                                                                                   
           Skin                                                                  1 (13%)                                            
   Gallbladder                                        (40)         (12)         (6)          (10)         (13)         (11)         
      Fibrosarcoma, Metastatic, Skin                                1 (8%)                                                          
   Intestine Large, Colon                             (50)         (21)         (8)          (17)         (16)         (16)         
   Intestine Large, Rectum                            (48)         (19)         (8)          (17)         (15)         (16)         
      Squamous Cell Carcinoma                          1 (2%)                                                                       
   Intestine Small, Ileum                             (44)         (18)         (7)          (16)         (14)         (13)         
   Intestine Small, Jejunum                           (45)         (20)         (10)         (18)         (16)         (18)         
      Adenocarcinoma                                   1 (2%)       1 (5%)       1 (10%)                                            
   Liver                                              (49)         (49)         (33)         (50)         (47)         (49)         
      Fibrosarcoma, Metastatic, Skin                                1 (2%)                                 1 (2%)                   
      Hemangioma                                                                              1 (2%)                                
      Hemangiosarcoma                                  2 (4%)       1 (2%)       1 (3%)       2 (4%)                    1 (2%)      
      Hemangiosarcoma, Multiple                        1 (2%)                                 1 (2%)       2 (4%)                   
      Hepatoblastoma                                                             1 (3%)       1 (2%)                    3 (6%)      
      Hepatoblastoma, Multiple                                                                                          1 (2%)      
      Hepatocellular Carcinoma                         9 (18%)      6 (12%)      3 (9%)      11 (22%)      7 (15%)     12 (24%)     
      Hepatocellular Carcinoma, Multiple               4 (8%)       2 (4%)       1 (3%)       8 (16%)      8 (17%)      7 (14%)     
      Hepatocellular Adenoma                           8 (16%)      2 (4%)       4 (12%)     12 (24%)     12 (26%)     14 (29%)     
      Hepatocellular Adenoma, Multiple                 3 (6%)       4 (8%)       2 (6%)       4 (8%)       3 (6%)       6 (12%)     
      Histiocytic Sarcoma                                           1 (2%)       1 (3%)       1 (2%)       2 (4%)       1 (2%)      
   Mesentery                                          (6)          (1)                                    (1)          (1)          
      Fibrosarcoma, Metastatic, Skin                                1 (100%)                                                        
      Histiocytic Sarcoma                                                                                  1 (100%)                 
   Pancreas                                           (48)         (20)         (7)          (17)         (15)         (17)         
   Pharynx                                            (1)                                                                           
      Squamous Cell Papilloma                          1 (100%)                                                                     
                                                             Page  12                                                               
NTP Experiment-Test: 05076-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 09/10/94  
Route: DOSED FEED                                                                                                 Time: 02:00:01  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 PPM        0 PPM        100 PPM      333 PPM      333 PPM      333 PPM         
                                                   0-0          10-0           1-1          0-3          3-3          10-3          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - cont                                                                                                            
   Salivary Glands                                    (50)         (21)         (8)          (19)         (15)         (17)         
      Sarcoma, Metastatic, Skin                                                  1 (13%)                                            
   Stomach, Forestomach                               (49)         (24)         (7)          (17)         (16)         (22)         
      Squamous Cell Papilloma                                       2 (8%)                                              2 (9%)      
   Stomach, Glandular                                 (48)         (21)         (7)          (17)         (15)         (18)         
   Tooth                                              (5)                                                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (23)         (8)          (19)         (15)         (19)         
      Adenocarcinoma, Metastatic, Uncertain                                                                                         
          Primary Site                                              2 (9%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (50)         (21)         (8)          (18)         (15)         (18)         
      Spindle Cell, Subcapsular, Adenoma               1 (2%)                                                                       
      Spindle Cell, Subcapsular, Adenoma, Multiple     1 (2%)                                                                       
   Adrenal Gland, Medulla                             (50)         (21)         (8)          (18)         (15)         (18)         
      Pheochromocytoma Benign                          1 (2%)                                                                       
   Islets, Pancreatic                                 (48)         (20)         (7)          (17)         (15)         (17)         
   Pituitary Gland                                    (44)         (42)         (28)         (42)         (41)         (45)         
      Pars Intermedia, Adenoma                         1 (2%)                                                                       
   Thyroid Gland                                      (50)         (46)         (33)         (49)         (47)         (48)         
      Follicular Cell, Adenoma                                      1 (2%)       1 (3%)       1 (2%)       1 (2%)       2 (4%)      
      Follicular Cell, Carcinoma                       1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (49)         (22)         (8)          (18)         (15)         (19)         
   Preputial Gland                                    (2)          (2)          (1)          (2)          (4)          (3)          
      Carcinoma                                                                                            1 (25%)                  
   Prostate                                           (50)         (22)         (8)          (18)         (15)         (19)         
   Seminal Vesicle                                    (4)          (2)                       (1)          (1)          (1)          
   Testes                                             (50)         (22)         (8)          (20)         (14)         (19)         
      Interstitial Cell, Adenoma                                                              1 (5%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page  13                                                               
NTP Experiment-Test: 05076-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 09/10/94  
Route: DOSED FEED                                                                                                 Time: 02:00:01  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 PPM        0 PPM        100 PPM      333 PPM      333 PPM      333 PPM         
                                                   0-0          10-0           1-1          0-3          3-3          10-3          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Blood                                              (1)                                                                           
   Bone Marrow                                        (49)         (21)         (8)          (18)         (13)         (19)         
   Lymph Node                                         (48)         (25)         (15)         (22)         (20)         (22)         
      Axillary, Fibrosarcoma, Metastatic, Skin                                                                          1 (5%)      
      Axillary, Sarcoma, Metastatic                                 1 (4%)                                                          
      Deep Cervical, Sarcoma, Metastatic, Skin                                   1 (7%)                                             
      Inguinal, Hepatoblastoma, Metastatic, Liver                                                                       1 (5%)      
      Mandibular, Histiocytic Sarcoma                                                                      1 (5%)                   
   Lymph Node, Mesenteric                             (14)         (11)         (7)          (4)          (8)          (6)          
      Fibrosarcoma, Metastatic, Skin                                                                       1 (13%)                  
      Histiocytic Sarcoma                                                        1 (14%)                   1 (13%)                  
   Spleen                                             (49)         (25)         (12)         (21)         (24)         (24)         
      Hemangiosarcoma                                  1 (2%)                                              1 (4%)                   
      Histiocytic Sarcoma                                                                                  1 (4%)                   
   Thymus                                             (29)         (11)         (4)          (11)         (11)         (11)         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (50)         (26)         (14)         (23)         (25)         (26)         
      Schwannoma Malignant                                                                                 1 (4%)                   
      Squamous Cell Carcinoma                                                                 1 (4%)                                
      Squamous Cell Papilloma                                                                              1 (4%)                   
      Subcutaneous Tissue, Fibroma                     1 (2%)                                                                       
      Subcutaneous Tissue, Fibrosarcoma                1 (2%)       5 (19%)      4 (29%)      6 (26%)      6 (24%)      8 (31%)     
      Subcutaneous Tissue, Fibrosarcoma, Multiple                                                          1 (4%)                   
      Subcutaneous Tissue, Fibrous Histiocytoma        1 (2%)                    1 (7%)                    2 (8%)                   
      Subcutaneous Tissue, Histiocytic Sarcoma                                                             1 (4%)                   
      Subcutaneous Tissue, Neurofibrosarcoma                                                               1 (4%)       1 (4%)      
      Subcutaneous Tissue, Sarcoma                     2 (4%)       1 (4%)       1 (7%)       1 (4%)                    3 (12%)     
      Subcutaneous Tissue, Schwannoma Malignant                                  1 (7%)                                 1 (4%)      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (21)         (8)          (19)         (15)         (19)         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page  14                                                               
NTP Experiment-Test: 05076-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 09/10/94  
Route: DOSED FEED                                                                                                 Time: 02:00:01  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 PPM        0 PPM        100 PPM      333 PPM      333 PPM      333 PPM         
                                                   0-0          10-0           1-1          0-3          3-3          10-3          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (49)         (33)         (50)         (47)         (49)         
      Adenocarcinoma, Metastatic, Uncertain                                                                                         
          Primary Site                                              1 (2%)                                                          
      Alveolar/Bronchiolar Adenoma                     4 (8%)       6 (12%)     10 (30%)      6 (12%)     11 (23%)      8 (16%)     
      Alveolar/Bronchiolar Adenoma, Multiple                        1 (2%)                                 1 (2%)       3 (6%)      
      Alveolar/Bronchiolar Carcinoma                   1 (2%)                    1 (3%)       1 (2%)                    6 (12%)     
      Alveolar/Bronchiolar Carcinoma, Multiple                                                             1 (2%)       1 (2%)      
      Fibrosarcoma, Metastatic, Skin                                                                                    1 (2%)      
      Hepatoblastoma, Metastatic, Liver                                                                                 1 (2%)      
      Hepatocellular Carcinoma, Metastatic, Liver     10 (20%)      1 (2%)       1 (3%)       2 (4%)       1 (2%)       1 (2%)      
      Histiocytic Sarcoma                                                                                  2 (4%)       1 (2%)      
   Nose                                               (50)         (21)         (8)          (19)         (16)         (18)         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (4)          (1)          (3)          (3)          (1)          (3)          
      Adenocarcinoma                                                                                                    1 (33%)     
      Adenoma                                          1 (25%)      1 (100%)     3 (100%)     2 (67%)      1 (100%)     1 (33%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (49)         (23)         (11)         (21)         (17)         (19)         
      Hepatocellular Carcinoma, Metastatic, Liver                                             1 (5%)       1 (6%)                   
   Urinary Bladder                                    (49)         (20)         (8)          (17)         (15)         (16)         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(49)        *(33)        *(50)        *(50)        *(49)         
      Histiocytic Sarcoma                                           1 (2%)       1 (3%)       1 (2%)       2 (4%)       1 (2%)      
      Lymphoma Malignant Histiocytic                   1 (2%)                                              1 (2%)                   
      Lymphoma Malignant Lymphocytic                   4 (8%)       1 (2%)       1 (3%)       3 (6%)       1 (2%)       2 (4%)      
      Lymphoma Malignant Mixed                         2 (4%)       3 (6%)       3 (9%)       2 (4%)       6 (12%)      6 (12%)     
      Lymphoma Malignant Undifferentiated Cell         2 (4%)                                              1 (2%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  15                                                               
NTP Experiment-Test: 05076-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 09/10/94  
Route: DOSED FEED                                                                                                 Time: 02:00:01  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          0 PPM        0 PPM        100 PPM      333 PPM      333 PPM      333 PPM         
                                                   0-0          10-0           1-1          0-3          3-3          10-3          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            35          28          25          40          39          48               
     Total Primary Neoplasms                           56          38          40          65          72          90               
                                                                                                                                    
   Total Animals with Benign Neoplasms                 16          14          15          23          25          30               
     Total Benign Neoplasms                            22          17          20          27          30          36               
                                                                                                                                    
   Total Animals with Malignant Neoplasms              28          19          16          31          30          41               
     Total Malignant Neoplasms                         34          21          20          38          42          54               
                                                                                                                                    
   Total Animals with Metastatic Neoplasms             10           3           2           3           2           4               
     Total Metastatic Neoplasm                         10           8           4           3           4           5               
                                                                                                                                    
   Total Animals with Malignant Neoplasms                           2                                                               
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  16                                                               
NTP Experiment-Test: 05076-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 09/10/94  
Route: DOSED FEED                                                                                                 Time: 02:00:01  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          1000 PPM     1000 PPM                                                            
                                                      0-10         10-10                                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           50                                                               
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                14           10                                                               
    Natural Death                                     13           15                                                               
  Survivors                                                                                                                         
    Terminal Sacrifice                                22           24                                                               
    Natural Death                                      1            1                                                               
  Animals Examined Microscopically                    50           50                                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Small, Jejunum                           (44)         (40)                                                             
   Liver                                              (50)         (49)                                                             
      Fibrosarcoma, Metastatic, Skin                   1 (2%)                                                                       
      Hemangiosarcoma                                  1 (2%)       2 (4%)                                                          
      Hemangiosarcoma, Multiple                                     1 (2%)                                                          
      Hepatoblastoma                                   4 (8%)       7 (14%)                                                         
      Hepatoblastoma, Multiple                         2 (4%)       3 (6%)                                                          
      Hepatocellular Carcinoma                         3 (6%)       5 (10%)                                                         
      Hepatocellular Carcinoma, Multiple              42 (84%)     40 (82%)                                                         
      Hepatocellular Adenoma                           4 (8%)       9 (18%)                                                         
      Hepatocellular Adenoma, Multiple                 5 (10%)      6 (12%)                                                         
      Histiocytic Sarcoma                              1 (2%)       1 (2%)                                                          
      Sarcoma, Metastatic                              1 (2%)                                                                       
   Mesentery                                          (5)          (3)                                                              
   Pancreas                                           (45)         (47)                                                             
   Salivary Glands                                    (50)         (49)                                                             
   Stomach, Glandular                                 (48)         (44)                                                             
   Tooth                                              (4)          (1)                                                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)                                                             
      Fibrosarcoma, Metastatic, Skin                                1 (2%)                                                          
      Hemangioma                                       2 (4%)                                                                       
      Hepatocellular Carcinoma, Metastatic, Liver                   1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page  17                                                               
NTP Experiment-Test: 05076-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 09/10/94  
Route: DOSED FEED                                                                                                 Time: 02:00:01  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          1000 PPM     1000 PPM                                                            
                                                      0-10         10-10                                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (49)                                                             
   Adrenal Gland, Medulla                             (50)         (49)                                                             
      Pheochromocytoma Benign                          1 (2%)       2 (4%)                                                          
   Pituitary Gland                                    (41)         (39)                                                             
      Pars Distalis, Adenoma                           8 (20%)      4 (10%)                                                         
      Pars Intermedia, Adenoma                         1 (2%)                                                                       
   Thyroid Gland                                      (50)         (49)                                                             
      Follicular Cell, Adenoma                         8 (16%)     11 (22%)                                                         
      Follicular Cell, Adenoma, Multiple              18 (36%)     22 (45%)                                                         
      Follicular Cell, Carcinoma                                    8 (16%)                                                         
      Follicular Cell, Carcinoma, Multiple             5 (10%)      1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (49)         (49)                                                             
   Preputial Gland                                    (2)          (1)                                                              
   Prostate                                           (47)         (49)                                                             
   Seminal Vesicle                                    (2)                                                                           
   Testes                                             (50)         (49)                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Blood                                              (1)                                                                           
   Bone Marrow                                        (49)         (47)                                                             
   Lymph Node                                         (47)         (48)                                                             
      Pancreatic, Sarcoma, Metastatic, Skin            1 (2%)                                                                       
   Lymph Node, Mesenteric                             (7)          (5)                                                              
      Histiocytic Sarcoma                              1 (14%)                                                                      
   Spleen                                             (48)         (47)                                                             
      Fibrosarcoma, Metastatic, Skin                   1 (2%)                                                                       
      Hemangiosarcoma                                  2 (4%)       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (49)         (50)                                                             
      Basosquamous Tumor Malignant                     1 (2%)                                                                       
      Squamous Cell Carcinoma                                       1 (2%)                                                          
      Subcutaneous Tissue, Fibrosarcoma                5 (10%)      5 (10%)                                                         
                                                             Page  18                                                               
NTP Experiment-Test: 05076-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 09/10/94  
Route: DOSED FEED                                                                                                 Time: 02:00:01  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          1000 PPM     1000 PPM                                                            
                                                      0-10         10-10                                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - cont                                                                                                         
      Subcutaneous Tissue, Sarcoma                     1 (2%)                                                                       
      Subcutaneous Tissue, Sarcoma, Multiple           1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (49)                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (49)                                                             
      Alveolar/Bronchiolar Adenoma                     4 (8%)       6 (12%)                                                         
      Alveolar/Bronchiolar Adenoma, Multiple           2 (4%)                                                                       
      Alveolar/Bronchiolar Carcinoma                   2 (4%)                                                                       
      Carcinoma, Metastatic, Thyroid Gland             1 (2%)       2 (4%)                                                          
      Carcinoma, Metastatic, Uncertain Primary Site                 1 (2%)                                                          
      Fibrosarcoma, Metastatic, Skin                   1 (2%)       1 (2%)                                                          
      Hepatoblastoma, Metastatic, Liver                2 (4%)       3 (6%)                                                          
      Hepatoblastoma, Metastatic, Uncertain                                                                                         
          Primary Site                                 1 (2%)                                                                       
      Hepatocellular Carcinoma, Metastatic, Liver     11 (22%)     21 (43%)                                                         
      Histiocytic Sarcoma                              1 (2%)                                                                       
   Nose                                               (50)         (49)                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                (1)                                                                           
      Pinna, Hemangioma                                1 (100%)                                                                     
   Harderian Gland                                    (18)         (6)                                                              
      Adenocarcinoma                                                1 (17%)                                                         
      Adenoma                                          4 (22%)      1 (17%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (49)                                                             
      Fibrosarcoma, Metastatic, Skin                   1 (2%)                                                                       
      Renal Tubule, Adenoma                            1 (2%)                                                                       
   Urinary Bladder                                    (48)         (48)                                                             
                                                             Page  19                                                               
NTP Experiment-Test: 05076-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 09/10/94  
Route: DOSED FEED                                                                                                 Time: 02:00:01  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          1000 PPM     1000 PPM                                                            
                                                      0-10         10-10                                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)                                                             
      Histiocytic Sarcoma                              1 (2%)       1 (2%)                                                          
      Lymphoma Malignant Lymphocytic                   3 (6%)       2 (4%)                                                          
      Lymphoma Malignant Mixed                         3 (6%)       3 (6%)                                                          
      Lymphoma Malignant Undifferentiated Cell         1 (2%)       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  20                                                               
NTP Experiment-Test: 05076-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 09/10/94  
Route: DOSED FEED                                                                                                 Time: 02:00:01  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          1000 PPM     1000 PPM                                                            
                                                      0-10         10-10                                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            47          47                                                               
     Total Primary Neoplasms                          136         143                                                               
                                                                                                                                    
   Total Animals with Benign Neoplasms                 36          41                                                               
     Total Benign Neoplasms                            59          61                                                               
                                                                                                                                    
   Total Animals with Malignant Neoplasms              46          46                                                               
     Total Malignant Neoplasms                         77          82                                                               
                                                                                                                                    
   Total Animals with Metastatic Neoplasms             17          27                                                               
     Total Metastatic Neoplasm                         21          30                                                               
                                                                                                                                    
   Total Animals with Malignant Neoplasms               1           1                                                               
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  21                                                               
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