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TR 388 Mouse Pathology Tables

NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Columbus                                      ETHYLENETHIOUREA                                   DATE: 09/10/94       
EXPERIMENT: 05076 TEST: 02                                                                                     TIME: 02:17:18       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: N01ES82151            ROUTE: DOSED FEED                                                                  NTP C#: 03372        
PATHOLOGIST: R. PERSING                      S. EUSTIS                                                         CAS: 96-45-7         
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               REASONS FOR REMOVAL:    ALL                                                                                          
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
                                                                                                                                    
               REMOVAL DATE RANGE:     ALL                                                                                          
                                                                                                                                    
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08    
LAB: Battelle Columbus                                      ETHYLENETHIOUREA                                   DATE: 09/10/94      
EXPERIMENT: 05076 TEST: 02                                                                                     TIME: 02:17:18      
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                       
CONT: N01ES82151            ROUTE: DOSED FEED                                                                  NTP C#: 03372       
PATHOLOGIST: R. PERSING                      S. EUSTIS                                                         CAS: 96-45-7        
 
 
 
 
 
                                                    MICE(B6C3F1)
                                              ----------------------------
             FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
             IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
 
 
                                                    ----------------
 
                                                    Adrenal Gland
                                                    Bone Marrow
                                                    Brain
                                                    Clitoral Gland
                                                    Epididymis
                                                    Gallbladder
                                                    Heart
                                                    Islets, Pancreatic
                                                    Kidney
                                                    Liver
                                                    Lung
                                                    Nose
                                                    Ovary
                                                    Pancreas
                                                    Parathyroid Gland
                                                    Pituitary Gland
                                                    Preputial Gland
                                                    Prostate
                                                    Salivary Glands
                                                    Spleen
                                                    Testes
                                                    Thymus
                                                    Thyroid Gland
                                                    Urinary Bladder
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Columbus                                      ETHYLENETHIOUREA                                   DATE: 09/10/94       
EXPERIMENT: 05076 TEST: 02                                                                                     TIME: 02:17:18       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01ES82151            ROUTE: DOSED FEED                                                                  NTP C#: 03372        
PATHOLOGIST: R. PERSING                      S. EUSTIS                                                         CAS: 96-45-7         
 
 
 
 
 
                                     SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
                                        IN THE ANALYSIS OF THE STUDY OF ETHYLENETHIOUREA
 
              ====================================================================================================
 
                                                           MALE MICE
                                                          -------------
                                 ORGAN                               MORPHOLOGY
                                -------                             ------------
 
                             Liver                         Hepatoblastoma
                                                           Hepatocellular Adenoma
                                                           Hepatocellular Carcinoma
                                                           Hepatocellular Carcinoma or Hepatoblastoma
                                                           Hepatocellular Carcinoma or Hepatocellular Adenoma
                                                           Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma
                             Lung                          Alveolar/Bronchiolar Adenoma
                                                           Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma
                             Pituitary Gland: Pars Distalis or Unspecified Site
                                                           Adenoma
                                                           Carcinoma or Adenoma
                             Thyroid Gland: Follicular Cell
                                                           Adenoma
                                                           Carcinoma
                                                           Carcinoma or Adenoma
                             All Organs                    Hemangioma
                                                           Hemangiosarcoma or Hemangioma
                                                           Benign Tumors
                                                           Malignant Tumors
                                                           Malignant and Benign Tumors
 
              ====================================================================================================
 
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Battelle Columbus                                      ETHYLENETHIOUREA                                   DATE: 09/10/94       
EXPERIMENT: 05076 TEST: 02                                                                                     TIME: 02:17:18       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01ES82151            ROUTE: DOSED FEED                                                                  NTP C#: 03372        
PATHOLOGIST: R. PERSING                      S. EUSTIS                                                         CAS: 96-45-7         
 
 
 
 
 
                                     SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
                                        IN THE ANALYSIS OF THE STUDY OF ETHYLENETHIOUREA
 
              ====================================================================================================
 
                                                           FEMALE MICE
                                                          -------------
                                 ORGAN                               MORPHOLOGY
                                -------                             ------------
 
                             Liver                         Hepatoblastoma
                                                           Hepatocellular Adenoma
                                                           Hepatocellular Carcinoma
                                                           Hepatocellular Carcinoma or Hepatoblastoma
                                                           Hepatocellular Carcinoma or Hepatocellular Adenoma
                                                           Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma
                             Mammary Gland                 Carcinoma
                             Pituitary Gland: Pars Distalis or Unspecified Site
                                                           Adenoma
                                                           Carcinoma or Adenoma
                             Pituitary Gland: Pars Intermedia
                                                           Adenoma
                             Thyroid Gland: Follicular Cell
                                                           Adenoma
                                                           Carcinoma
                                                           Carcinoma or Adenoma
                             All Organs                    Histiocytic Sarcoma
                                                           Benign Tumors
                                                           Malignant Tumors
                                                           Malignant and Benign Tumors
 
              ====================================================================================================
         DATE: 09/10/94                     EXPERIMENT: 05076 TEST: 02                                                 PAGE   1
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ETHYLENETHIOUREA
 
                                                 MALE TERMINAL SACRIFICE AT 107 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 106 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 PPM        100 PPM      333 PPM      1000 PPM  |   0 PPM        100 PPM      333 PPM      1000 PPM  |
|                       |   10-0         1-1          10-3         10-10     |   10-0         1-1          10-3         10-10     |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Gland: Non-medullary, Non-cortical                                                                                       |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/71 (3%)    0/8 (0%)     0/51 (0%)    0/99 (0%)  |  0/62 (0%)    0/8 (0%)     1/36 (3%)    0/100 (0%) |
|ADJUSTED (b)           |   6.5%         0.0%         0.0%         0.0%      |   0.0%         0.0%         0.7%         0.0%      |
|TERMINAL (d)           |  2/31 (6%)    0/1 (0%)     0/2 (0%)     0/48 (0%)  |  0/35 (0%)    0/0          0/3 (0%)     0/60 (0%)  |
|FIRST INCIDENCE (DAYS) |   743 (T)      ---          ---          ---       |   ---          ---          605          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.104N     P=0.965N     P=0.873N     P=0.149N   |  P=0.759N       (e)        P=0.596        (e)      |
|INCIDENTAL TUMOR       |  P=0.104N     P=0.965N     P=0.873N     P=0.149N   |  P=0.682N       (e)        P=0.419        (e)      |
|LOGISTIC REGRESSION    |  P=0.104N     P=0.965N     P=0.873N     P=0.149N   |  P=0.608N       (e)        P=0.388        (e)      |
|COCHRAN-ARMITAGE       |  P=0.136N                                          |  P=0.604N                                          |
|FISHER EXACT           |               P=0.807N     P=0.337N     P=0.173N   |                 (e)        P=0.367        (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Pheochromocytoma Benign                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/71 (1%)    0/8 (0%)     0/51 (0%)    3/99 (3%)  |  1/61 (2%)    0/8 (0%)     0/35 (0%)    2/100 (2%) |
|ADJUSTED (b)           |   3.2%         0.0%         0.0%         5.4%      |   2.9%         0.0%         0.0%         3.3%      |
|TERMINAL (d)           |  1/31 (3%)    0/1 (0%)     0/2 (0%)     2/48 (4%)  |  1/35 (3%)    0/0          0/3 (0%)     2/60 (3%)  |
|FIRST INCIDENCE (DAYS) |   743 (T)      ---          ---          671       |   740 (T)      ---          ---          740 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.303      P=0.996N     P=0.967N     P=0.444    |  P=0.597        (e)        P=0.941N     P=0.684    |
|INCIDENTAL TUMOR       |  P=0.369      P=0.996N     P=0.967N     P=0.528    |  P=0.597        (e)        P=0.941N     P=0.684    |
|LOGISTIC REGRESSION    |  P=0.358      P=0.996N     P=0.967N     P=0.529    |  P=0.597        (e)        P=0.941N     P=0.684    |
|COCHRAN-ARMITAGE       |  P=0.238                                           |  P=0.493                                           |
|FISHER EXACT           |               P=0.899N     P=0.582N     P=0.444    |               P=0.884N     P=0.635N     P=0.679    |
|=================================================================================================================================|
 
         DATE: 09/10/94                     EXPERIMENT: 05076 TEST: 02                                                 PAGE   2
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ETHYLENETHIOUREA
 
                                                 MALE TERMINAL SACRIFICE AT 107 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 106 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 PPM        100 PPM      333 PPM      1000 PPM  |   0 PPM        100 PPM      333 PPM      1000 PPM  |
|                       |   10-0         1-1          10-3         10-10     |   10-0         1-1          10-3         10-10     |
|=================================================================================================================================|
|                                                                                                                                 |
|Bone                                                                                                                             |
|     Osteosarcoma                                                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/99 (0%)    0/33 (0%)    0/149 (0%)   0/100 (0%) |  2/100 (2%)   0/29 (0%)    1/150 (1%)   0/100 (0%) |
|ADJUSTED (b)           |   0.0%         0.0%         0.0%         0.0%      |   2.5%         0.0%         0.7%         0.0%      |
|TERMINAL (d)           |  0/58 (0%)    0/26 (0%)    0/95 (0%)    0/48 (0%)  |  1/73 (1%)    0/21 (0%)    0/115 (0%)   0/60 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          ---          ---       |   642          ---          625          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |    (e)          (e)          (e)          (e)      |  P=0.214N     P=0.541N     P=0.337N     P=0.263N   |
|INCIDENTAL TUMOR       |    (e)          (e)          (e)          (e)      |  P=0.189N     P=0.464N     P=0.490N     P=0.228N   |
|LOGISTIC REGRESSION    |    (e)          (e)          (e)          (e)      |  P=0.187N     P=0.531N     P=0.431N     P=0.236N   |
|COCHRAN-ARMITAGE       |    (e)                                             |  P=0.205N                                          |
|FISHER EXACT           |                 (e)          (e)          (e)      |               P=0.600N     P=0.351N     P=0.249N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Harderian Gland                                                                                                                  |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/99 (2%)    3/33 (9%)    4/149 (3%)   5/100 (5%) |  4/100 (4%)   0/29 (0%)    4/150 (3%)   2/100 (2%) |
|ADJUSTED (b)           |   3.2%        11.5%         3.8%         9.2%      |   5.2%         0.0%         3.4%         3.3%      |
|TERMINAL (d)           |  1/58 (2%)    3/26 (12%)   2/95 (2%)    3/48 (6%)  |  2/73 (3%)    0/21 (0%)    3/115 (3%)   2/60 (3%)  |
|FIRST INCIDENCE (DAYS) |   666          743 (T)      669          694       |   698          ---          738          740 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.215      P=0.169      P=0.595      P=0.189    |  P=0.472N     P=0.323N     P=0.387N     P=0.426N   |
|INCIDENTAL TUMOR       |  P=0.448      P=0.107      P=0.660N     P=0.355    |  P=0.347N     P=0.342N     P=0.331N     P=0.300N   |
|LOGISTIC REGRESSION    |  P=0.325      P=0.142      P=0.599      P=0.261    |  P=0.412N     P=0.319N     P=0.384N     P=0.361N   |
|COCHRAN-ARMITAGE       |  P=0.314                                           |  P=0.379N                                          |
|FISHER EXACT           |               P=0.099      P=0.546      P=0.227    |               P=0.356N     P=0.405N     P=0.341N   |
|=================================================================================================================================|
 
         DATE: 09/10/94                     EXPERIMENT: 05076 TEST: 02                                                 PAGE   3
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ETHYLENETHIOUREA
 
                                                 MALE TERMINAL SACRIFICE AT 107 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 106 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 PPM        100 PPM      333 PPM      1000 PPM  |   0 PPM        100 PPM      333 PPM      1000 PPM  |
|                       |   10-0         1-1          10-3         10-10     |   10-0         1-1          10-3         10-10     |
|=================================================================================================================================|
|                                                                                                                                 |
|Harderian Gland                                                                                                                  |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/99 (0%)    0/33 (0%)    1/149 (1%)   1/100 (1%) |  1/100 (1%)   1/29 (3%)    2/150 (1%)   1/100 (1%) |
|ADJUSTED (b)           |   0.0%         0.0%         1.1%         2.1%      |   1.4%         3.8%         1.7%         1.7%      |
|TERMINAL (d)           |  0/58 (0%)    0/26 (0%)    1/95 (1%)    1/48 (2%)  |  1/73 (1%)    0/21 (0%)    2/115 (2%)   1/60 (2%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          743 (T)      743 (T)   |   740 (T)      562          740 (T)      740 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.293        (e)        P=0.598      P=0.462    |  P=0.598N     P=0.463      P=0.655      P=0.717    |
|INCIDENTAL TUMOR       |  P=0.293        (e)        P=0.598      P=0.462    |  P=0.573N     P=0.536      P=0.655      P=0.717    |
|LOGISTIC REGRESSION    |  P=0.293        (e)        P=0.598      P=0.462    |  P=0.537N     P=0.481      P=0.655      P=0.717    |
|COCHRAN-ARMITAGE       |  P=0.357                                           |  P=0.539N                                          |
|FISHER EXACT           |                 (e)        P=0.601      P=0.503    |               P=0.400      P=0.649      P=0.751N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Harderian Gland                                                                                                                  |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/99 (2%)    3/33 (9%)    5/149 (3%)   6/100 (6%) |  5/100 (5%)   1/29 (3%)    6/150 (4%)   3/100 (3%) |
|ADJUSTED (b)           |   3.2%        11.5%         4.9%        11.2%      |   6.5%         3.8%         5.2%         5.0%      |
|TERMINAL (d)           |  1/58 (2%)    3/26 (12%)   3/95 (3%)    4/48 (8%)  |  3/73 (4%)    0/21 (0%)    5/115 (4%)   3/60 (5%)  |
|FIRST INCIDENCE (DAYS) |   666          743 (T)      669          694       |   698          562          738          740 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.121      P=0.169      P=0.470      P=0.111    |  P=0.440N     P=0.569N     P=0.443N     P=0.463N   |
|INCIDENTAL TUMOR       |  P=0.293      P=0.107      P=0.552      P=0.223    |  P=0.327N     P=0.548N     P=0.395N     P=0.351N   |
|LOGISTIC REGRESSION    |  P=0.213      P=0.142      P=0.479      P=0.169    |  P=0.352N     P=0.557N     P=0.437N     P=0.394N   |
|COCHRAN-ARMITAGE       |  P=0.209                                           |  P=0.335N                                          |
|FISHER EXACT           |               P=0.099      P=0.420      P=0.143    |               P=0.593N     P=0.467N     P=0.360N   |
|=================================================================================================================================|
 
         DATE: 09/10/94                     EXPERIMENT: 05076 TEST: 02                                                 PAGE   4
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ETHYLENETHIOUREA
 
                                                 MALE TERMINAL SACRIFICE AT 107 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 106 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 PPM        100 PPM      333 PPM      1000 PPM  |   0 PPM        100 PPM      333 PPM      1000 PPM  |
|                       |   10-0         1-1          10-3         10-10     |   10-0         1-1          10-3         10-10     |
|=================================================================================================================================|
|                                                                                                                                 |
|Heart                                                                                                                            |
|     Hemangioma                                                                                                                  |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/73 (0%)    0/8 (0%)     0/53 (0%)    2/100 (2%) |  0/63 (0%)    0/8 (0%)     0/38 (0%)    0/100 (0%) |
|ADJUSTED (b)           |   0.0%         0.0%         0.0%         3.7%      |   0.0%         0.0%         0.0%         0.0%      |
|TERMINAL (d)           |  0/32 (0%)    0/1 (0%)     0/2 (0%)     1/48 (2%)  |  0/36 (0%)    0/0          0/3 (0%)     0/60 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          ---          700       |   ---          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.125        (e)          (e)        P=0.276    |    (e)          (e)          (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.209        (e)          (e)        P=0.406    |    (e)          (e)          (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.210        (e)          (e)        P=0.369    |    (e)          (e)          (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.147                                           |    (e)                                             |
|FISHER EXACT           |                 (e)          (e)        P=0.333    |                 (e)          (e)          (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|Intestine Small: Jejunum                                                                                                         |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/99 (2%)    1/33 (3%)    0/149 (0%)   0/100 (0%) |  0/100 (0%)   0/29 (0%)    0/150 (0%)   0/100 (0%) |
|ADJUSTED (b)           |   3.4%         3.8%         0.0%         0.0%      |   0.0%         0.0%         0.0%         0.0%      |
|TERMINAL (d)           |  2/58 (3%)    1/26 (4%)    0/95 (0%)    0/48 (0%)  |  0/73 (0%)    0/21 (0%)    0/115 (0%)   0/60 (0%)  |
|FIRST INCIDENCE (DAYS) |   743 (T)      743 (T)      ---          ---       |   ---          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.145N     P=0.706      P=0.139N     P=0.281N   |    (e)          (e)          (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.145N     P=0.706      P=0.139N     P=0.281N   |    (e)          (e)          (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.145N     P=0.706      P=0.139N     P=0.281N   |    (e)          (e)          (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.121N                                          |    (e)                                             |
|FISHER EXACT           |               P=0.581      P=0.158N     P=0.246N   |                 (e)          (e)          (e)      |
|=================================================================================================================================|
 
         DATE: 09/10/94                     EXPERIMENT: 05076 TEST: 02                                                 PAGE   5
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ETHYLENETHIOUREA
 
                                                 MALE TERMINAL SACRIFICE AT 107 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 106 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 PPM        100 PPM      333 PPM      1000 PPM  |   0 PPM        100 PPM      333 PPM      1000 PPM  |
|                       |   10-0         1-1          10-3         10-10     |   10-0         1-1          10-3         10-10     |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hemangiosarcoma                                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  4/98 (4%)    1/33 (3%)    6/146 (4%)   4/99 (4%)  |  2/99 (2%)    0/28 (0%)    8/150 (5%)   2/100 (2%) |
|ADJUSTED (b)           |   6.4%         3.8%         5.9%         6.9%      |   2.7%         0.0%         6.5%         3.3%      |
|TERMINAL (d)           |  3/58 (5%)    1/26 (4%)    4/95 (4%)    2/48 (4%)  |  2/73 (3%)    0/20 (0%)    5/115 (4%)   2/60 (3%)  |
|FIRST INCIDENCE (DAYS) |   565          743 (T)      623          685       |   740 (T)      ---          605          740 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.462      P=0.496N     P=0.564N     P=0.597    |  P=0.568      P=0.548N     P=0.186      P=0.622    |
|INCIDENTAL TUMOR       |  P=0.561N     P=0.505N     P=0.536N     P=0.552N   |  P=0.567N     P=0.548N     P=0.139      P=0.622    |
|LOGISTIC REGRESSION    |  P=0.589N     P=0.538N     P=0.551N     P=0.584N   |  P=0.557N     P=0.548N     P=0.163      P=0.622    |
|COCHRAN-ARMITAGE       |  P=0.570                                           |  P=0.541N                                          |
|FISHER EXACT           |               P=0.629N     P=0.631      P=0.634N   |               P=0.606N     P=0.166      P=0.686N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatoblastoma                                                                                                              |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/98 (0%)    1/33 (3%)    5/146 (3%)  16/99 (16%) |  0/99 (0%)    0/28 (0%)    2/150 (1%)  11/100 (11%)|
|ADJUSTED (b)           |   0.0%         3.8%         5.2%        27.0%      |   0.0%         0.0%         1.6%        16.2%      |
|TERMINAL (d)           |  0/58 (0%)    1/26 (4%)    4/95 (4%)    9/48 (19%) |  0/73 (0%)    0/20 (0%)    1/115 (1%)   7/60 (12%) |
|FIRST INCIDENCE (DAYS) |   ---          743 (T)      740          618       |   ---          ---          653          642       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P<0.001 **   P=0.340      P=0.098      P<0.001 ** |  P<0.001 **     (e)        P=0.348      P<0.001 ** |
|INCIDENTAL TUMOR       |  P<0.001 **   P=0.340      P=0.111      P<0.001 ** |  P<0.001 **     (e)        P=0.376      P=0.001 ** |
|LOGISTIC REGRESSION    |  P<0.001 **   P=0.340      P=0.099      P<0.001 ** |  P<0.001 **     (e)        P=0.313      P<0.001 ** |
|COCHRAN-ARMITAGE       |  P<0.001 **                                        |  P<0.001 **                                        |
|FISHER EXACT           |               P=0.252      P=0.075      P<0.001 ** |                 (e)        P=0.362      P<0.001 ** |
|=================================================================================================================================|
 
         DATE: 09/10/94                     EXPERIMENT: 05076 TEST: 02                                                 PAGE   6
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ETHYLENETHIOUREA
 
                                                 MALE TERMINAL SACRIFICE AT 107 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 106 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 PPM        100 PPM      333 PPM      1000 PPM  |   0 PPM        100 PPM      333 PPM      1000 PPM  |
|                       |   10-0         1-1          10-3         10-10     |   10-0         1-1          10-3         10-10     |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Adenoma                                                                                                      |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 17/98 (17%)   6/33 (18%)  51/146 (35%) 24/99 (24%) |  3/99 (3%)    2/28 (7%)  102/150 (68%) 31/100 (31%)|
|ADJUSTED (b)           |  26.1%        21.9%        45.8%        36.0%      |   4.1%        10.0%        74.8%        43.7%      |
|TERMINAL (d)           | 12/58 (21%)   5/26 (19%)  37/95 (39%)  11/48 (23%) |  3/73 (4%)    2/20 (10%)  81/115 (70%) 22/60 (37%) |
|FIRST INCIDENCE (DAYS) |   351          532          526          449       |   740 (T)      740 (T)      503          443       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.088      P=0.413N     P=0.012 *    P=0.111    |  P<0.001 **   P=0.318      P<0.001 **   P<0.001 ** |
|INCIDENTAL TUMOR       |  P=0.371      P=0.470N     P=0.012 *    P=0.301    |  P=0.003 **   P=0.318      P<0.001 **   P<0.001 ** |
|LOGISTIC REGRESSION    |  P=0.489      P=0.521N     P=0.011 *    P=0.395    |  P=0.003 **   P=0.318      P<0.001 **   P<0.001 ** |
|COCHRAN-ARMITAGE       |  P=0.278                                           |  P=0.006 **                                        |
|FISHER EXACT           |               P=0.550      P=0.002 **   P=0.155    |               P=0.304      P<0.001 **   P<0.001 ** |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma                                                                                                    |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 21/98 (21%)   4/33 (12%)  53/146 (36%) 90/99 (91%) |  7/99 (7%)    2/28 (7%)   83/150 (55%) 95/100 (95%)|
|ADJUSTED (b)           |  32.8%        14.1%        50.5%       100.0%      |   8.8%         8.0%        64.6%        98.9%      |
|TERMINAL (d)           | 16/58 (28%)   2/26 (8%)   44/95 (46%)  48/48 (100%)|  5/73 (7%)    0/20 (0%)   70/115 (61%) 59/60 (98%) |
|FIRST INCIDENCE (DAYS) |   520          532          535          507       |   523          529          621          443       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P<0.001 **   P=0.072N     P=0.033 *    P<0.001 ** |  P<0.001 **   P=0.652      P<0.001 **   P<0.001 ** |
|INCIDENTAL TUMOR       |  P<0.001 **   P=0.089N     P=0.048 *    P<0.001 ** |  P<0.001 **   P=0.569      P<0.001 **   P<0.001 ** |
|LOGISTIC REGRESSION    |  P<0.001 **   P=0.096N     P=0.056      P<0.001 ** |  P<0.001 **   P=0.634N     P<0.001 **   P<0.001 ** |
|COCHRAN-ARMITAGE       |  P<0.001 **                                        |  P<0.001 **                                        |
|FISHER EXACT           |               P=0.180N     P=0.009 **   P<0.001 ** |               P=0.632      P<0.001 **   P<0.001 ** |
|=================================================================================================================================|
 
         DATE: 09/10/94                     EXPERIMENT: 05076 TEST: 02                                                 PAGE   7
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ETHYLENETHIOUREA
 
                                                 MALE TERMINAL SACRIFICE AT 107 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 106 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 PPM        100 PPM      333 PPM      1000 PPM  |   0 PPM        100 PPM      333 PPM      1000 PPM  |
|                       |   10-0         1-1          10-3         10-10     |   10-0         1-1          10-3         10-10     |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma or Hepatoblastoma                                                                                  |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 21/98 (21%)   4/33 (12%)  53/146 (36%) 90/99 (91%) |  7/99 (7%)    2/28 (7%)   83/150 (55%) 95/100 (95%)|
|ADJUSTED (b)           |  32.8%        14.1%        50.5%       100.0%      |   8.8%         8.0%        64.6%        98.9%      |
|TERMINAL (d)           | 16/58 (28%)   2/26 (8%)   44/95 (46%)  48/48 (100%)|  5/73 (7%)    0/20 (0%)   70/115 (61%) 59/60 (98%) |
|FIRST INCIDENCE (DAYS) |   520          532          535          507       |   523          529          621          443       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P<0.001 **   P=0.072N     P=0.033 *    P<0.001 ** |  P<0.001 **   P=0.652      P<0.001 **   P<0.001 ** |
|INCIDENTAL TUMOR       |  P<0.001 **   P=0.089N     P=0.048 *    P<0.001 ** |  P<0.001 **   P=0.569      P<0.001 **   P<0.001 ** |
|LOGISTIC REGRESSION    |  P<0.001 **   P=0.096N     P=0.056      P<0.001 ** |  P<0.001 **   P=0.634N     P<0.001 **   P<0.001 ** |
|COCHRAN-ARMITAGE       |  P<0.001 **                                        |  P<0.001 **                                        |
|FISHER EXACT           |               P=0.180N     P=0.009 **   P<0.001 ** |               P=0.632      P<0.001 **   P<0.001 ** |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma or Hepatocellular Adenoma                                                                          |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 33/98 (34%)   9/33 (27%)  92/146 (63%) 93/99 (94%) |  9/99 (9%)    4/28 (14%) 136/150 (91%) 97/100 (97%)|
|ADJUSTED (b)           |  49.3%        32.0%        78.3%       100.0%      |  11.5%        17.2%        96.4%       100.0%      |
|TERMINAL (d)           | 25/58 (43%)   7/26 (27%)  70/95 (74%)  48/48 (100%)|  7/73 (10%)   2/20 (10%) 110/115 (96%) 60/60 (100%)|
|FIRST INCIDENCE (DAYS) |   351          532          526          449       |   523          529          503          443       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P<0.001 **   P=0.097N     P<0.001 **   P<0.001 ** |  P<0.001 **   P=0.324      P<0.001 **   P<0.001 ** |
|INCIDENTAL TUMOR       |  P<0.001 **   P=0.137N     P<0.001 **   P<0.001 ** |  P<0.001 **   P=0.239      P<0.001 **   P<0.001 ** |
|LOGISTIC REGRESSION    |  P<0.001 **   P=0.152N     P<0.001 **   P<0.001 ** |  P<0.001 **   P=0.343      P<0.001 **   P<0.001 ** |
|COCHRAN-ARMITAGE       |  P<0.001 **                                        |  P<0.001 **                                        |
|FISHER EXACT           |               P=0.325N     P<0.001 **   P<0.001 ** |               P=0.313      P<0.001 **   P<0.001 ** |
|=================================================================================================================================|
 
         DATE: 09/10/94                     EXPERIMENT: 05076 TEST: 02                                                 PAGE   8
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ETHYLENETHIOUREA
 
                                                 MALE TERMINAL SACRIFICE AT 107 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 106 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 PPM        100 PPM      333 PPM      1000 PPM  |   0 PPM        100 PPM      333 PPM      1000 PPM  |
|                       |   10-0         1-1          10-3         10-10     |   10-0         1-1          10-3         10-10     |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Carcinoma, Hepatocellular Adenoma, or Hepatoblastoma                                                         |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 33/98 (34%)   9/33 (27%)  92/146 (63%) 93/99 (94%) |  9/99 (9%)    4/28 (14%) 136/150 (91%) 97/100 (97%)|
|ADJUSTED (b)           |  49.3%        32.0%        78.3%       100.0%      |  11.5%        17.2%        96.4%       100.0%      |
|TERMINAL (d)           | 25/58 (43%)   7/26 (27%)  70/95 (74%)  48/48 (100%)|  7/73 (10%)   2/20 (10%) 110/115 (96%) 60/60 (100%)|
|FIRST INCIDENCE (DAYS) |   351          532          526          449       |   523          529          503          443       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P<0.001 **   P=0.097N     P<0.001 **   P<0.001 ** |  P<0.001 **   P=0.324      P<0.001 **   P<0.001 ** |
|INCIDENTAL TUMOR       |  P<0.001 **   P=0.137N     P<0.001 **   P<0.001 ** |  P<0.001 **   P=0.239      P<0.001 **   P<0.001 ** |
|LOGISTIC REGRESSION    |  P<0.001 **   P=0.152N     P<0.001 **   P<0.001 ** |  P<0.001 **   P=0.343      P<0.001 **   P<0.001 ** |
|COCHRAN-ARMITAGE       |  P<0.001 **                                        |  P<0.001 **                                        |
|FISHER EXACT           |               P=0.325N     P<0.001 **   P<0.001 ** |               P=0.313      P<0.001 **   P<0.001 ** |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Adenoma                                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 11/99 (11%)  10/33 (30%)  29/146 (20%) 12/99 (12%) |  5/100 (5%)   1/29 (3%)   15/150 (10%)  4/100 (4%) |
|ADJUSTED (b)           |  18.6%        38.5%        29.0%        18.8%      |   6.3%         4.8%        12.9%         6.7%      |
|TERMINAL (d)           | 10/58 (17%)  10/26 (38%)  25/95 (26%)   5/48 (10%) |  3/73 (4%)    1/21 (5%)   14/115 (12%)  4/60 (7%)  |
|FIRST INCIDENCE (DAYS) |   716          743 (T)      649          641       |   491          740 (T)      738          740 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.519N     P=0.054      P=0.094      P=0.407    |  P=0.514N     P=0.564N     P=0.140      P=0.603N   |
|INCIDENTAL TUMOR       |  P=0.236N     P=0.039 *    P=0.122      P=0.486N   |  P=0.462N     P=0.620N     P=0.119      P=0.573N   |
|LOGISTIC REGRESSION    |  P=0.246N     P=0.042 *    P=0.122      P=0.578N   |  P=0.402N     P=0.555N     P=0.135      P=0.507N   |
|COCHRAN-ARMITAGE       |  P=0.253N                                          |  P=0.362N                                          |
|FISHER EXACT           |               P=0.012 *    P=0.048 *    P=0.500    |               P=0.593N     P=0.116      P=0.500N   |
|=================================================================================================================================|
 
         DATE: 09/10/94                     EXPERIMENT: 05076 TEST: 02                                                 PAGE   9
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ETHYLENETHIOUREA
 
                                                 MALE TERMINAL SACRIFICE AT 107 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 106 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 PPM        100 PPM      333 PPM      1000 PPM  |   0 PPM        100 PPM      333 PPM      1000 PPM  |
|                       |   10-0         1-1          10-3         10-10     |   10-0         1-1          10-3         10-10     |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Carcinoma                                                                                              |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/99 (1%)    1/33 (3%)    9/146 (6%)   2/99 (2%)  |  5/100 (5%)   0/29 (0%)    4/150 (3%)   1/100 (1%) |
|ADJUSTED (b)           |   1.7%         3.7%         8.5%         3.4%      |   6.8%         0.0%         3.3%         1.7%      |
|TERMINAL (d)           |  1/58 (2%)    0/26 (0%)    6/95 (6%)    1/48 (2%)  |  5/73 (7%)    0/21 (0%)    3/115 (3%)   1/60 (2%)  |
|FIRST INCIDENCE (DAYS) |   743 (T)      705          562          671       |   740 (T)      ---          647          740 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.549      P=0.567      P=0.071      P=0.475    |  P=0.168N     P=0.249N     P=0.240N     P=0.156N   |
|INCIDENTAL TUMOR       |  P=0.481N     P=0.421      P=0.076      P=0.572    |  P=0.148N     P=0.249N     P=0.228N     P=0.156N   |
|LOGISTIC REGRESSION    |  P=0.542N     P=0.547      P=0.064      P=0.534    |  P=0.138N     P=0.249N     P=0.240N     P=0.156N   |
|COCHRAN-ARMITAGE       |  P=0.566N                                          |  P=0.126N                                          |
|FISHER EXACT           |               P=0.439      P=0.041 *    P=0.500    |               P=0.274N     P=0.263N     P=0.106N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma                                                              |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 12/99 (12%)  11/33 (33%)  35/146 (24%) 14/99 (14%) | 10/100 (10%)  1/29 (3%)   19/150 (13%)  5/100 (5%) |
|ADJUSTED (b)           |  20.3%        40.7%        33.6%        21.7%      |  13.0%         4.8%        16.1%         8.3%      |
|TERMINAL (d)           | 11/58 (19%)  10/26 (38%)  28/95 (29%)   6/48 (13%) |  8/73 (11%)   1/21 (5%)   17/115 (15%)  5/60 (8%)  |
|FIRST INCIDENCE (DAYS) |   716          705          562          641       |   491          740 (T)      647          740 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.541      P=0.041 *    P=0.040 *    P=0.325    |  P=0.253N     P=0.237N     P=0.381      P=0.237N   |
|INCIDENTAL TUMOR       |  P=0.216N     P=0.021 *    P=0.054      P=0.549N   |  P=0.205N     P=0.263N     P=0.359      P=0.217N   |
|LOGISTIC REGRESSION    |  P=0.231N     P=0.026 *    P=0.059      P=0.525    |  P=0.164N     P=0.237N     P=0.376      P=0.156N   |
|COCHRAN-ARMITAGE       |  P=0.276N                                          |  P=0.137N                                          |
|FISHER EXACT           |               P=0.008 **   P=0.015 *    P=0.417    |               P=0.242N     P=0.332      P=0.141N   |
|=================================================================================================================================|
 
         DATE: 09/10/94                     EXPERIMENT: 05076 TEST: 02                                                 PAGE  10
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ETHYLENETHIOUREA
 
                                                 MALE TERMINAL SACRIFICE AT 107 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 106 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 PPM        100 PPM      333 PPM      1000 PPM  |   0 PPM        100 PPM      333 PPM      1000 PPM  |
|                       |   10-0         1-1          10-3         10-10     |   10-0         1-1          10-3         10-10     |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/99 (0%)    0/33 (0%)    0/149 (0%)   0/100 (0%) |  1/100 (1%)   1/29 (3%)    7/150 (5%)   1/100 (1%) |
|ADJUSTED (b)           |   0.0%         0.0%         0.0%         0.0%      |   1.4%         4.8%         5.3%         1.3%      |
|TERMINAL (d)           |  0/58 (0%)    0/26 (0%)    0/95 (0%)    0/48 (0%)  |  1/73 (1%)    1/21 (5%)    2/115 (2%)   0/60 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          ---          ---       |   740 (T)      740 (T)      440          677       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |    (e)          (e)          (e)          (e)      |  P=0.470N     P=0.464      P=0.121      P=0.736    |
|INCIDENTAL TUMOR       |    (e)          (e)          (e)          (e)      |  P=0.338N     P=0.464      P=0.059      P=0.715N   |
|LOGISTIC REGRESSION    |    (e)          (e)          (e)          (e)      |  P=0.360N     P=0.464      P=0.044 *    P=0.759    |
|COCHRAN-ARMITAGE       |    (e)                                             |  P=0.411N                                          |
|FISHER EXACT           |                 (e)          (e)          (e)      |               P=0.400      P=0.103      P=0.751N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Fibroadenoma                                                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/99 (0%)    0/33 (0%)    0/149 (0%)   0/100 (0%) |  2/100 (2%)   0/29 (0%)    0/150 (0%)   1/100 (1%) |
|ADJUSTED (b)           |   0.0%         0.0%         0.0%         0.0%      |   2.7%         0.0%         0.0%         1.7%      |
|TERMINAL (d)           |  0/58 (0%)    0/26 (0%)    0/95 (0%)    0/48 (0%)  |  2/73 (3%)    0/21 (0%)    0/115 (0%)   1/60 (2%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          ---          ---       |   740 (T)      ---          ---          740 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |    (e)          (e)          (e)          (e)      |  P=0.634N     P=0.536N     P=0.146N     P=0.568N   |
|INCIDENTAL TUMOR       |    (e)          (e)          (e)          (e)      |  P=0.634N     P=0.536N     P=0.146N     P=0.568N   |
|LOGISTIC REGRESSION    |    (e)          (e)          (e)          (e)      |  P=0.634N     P=0.536N     P=0.146N     P=0.568N   |
|COCHRAN-ARMITAGE       |    (e)                                             |  P=0.574N                                          |
|FISHER EXACT           |                 (e)          (e)          (e)      |               P=0.600N     P=0.159N     P=0.500N   |
|=================================================================================================================================|
 
         DATE: 09/10/94                     EXPERIMENT: 05076 TEST: 02                                                 PAGE  11
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ETHYLENETHIOUREA
 
                                                 MALE TERMINAL SACRIFICE AT 107 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 106 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 PPM        100 PPM      333 PPM      1000 PPM  |   0 PPM        100 PPM      333 PPM      1000 PPM  |
|                       |   10-0         1-1          10-3         10-10     |   10-0         1-1          10-3         10-10     |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Fibroma, Fibroadenoma, Carcinoma, or Adenoma                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/99 (0%)    0/33 (0%)    0/149 (0%)   0/100 (0%) |  3/100 (3%)   1/29 (3%)    7/150 (5%)   2/100 (2%) |
|ADJUSTED (b)           |   0.0%         0.0%         0.0%         0.0%      |   4.1%         4.8%         5.3%         2.9%      |
|TERMINAL (d)           |  0/58 (0%)    0/26 (0%)    0/95 (0%)    0/48 (0%)  |  3/73 (4%)    1/21 (5%)    2/115 (2%)   1/60 (2%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          ---          ---       |   740 (T)      740 (T)      440          677       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |    (e)          (e)          (e)          (e)      |  P=0.438N     P=0.684      P=0.400      P=0.573N   |
|INCIDENTAL TUMOR       |    (e)          (e)          (e)          (e)      |  P=0.323N     P=0.684      P=0.289      P=0.514N   |
|LOGISTIC REGRESSION    |    (e)          (e)          (e)          (e)      |  P=0.332N     P=0.684      P=0.257      P=0.524N   |
|COCHRAN-ARMITAGE       |    (e)                                             |  P=0.362N                                          |
|FISHER EXACT           |                 (e)          (e)          (e)      |               P=0.644      P=0.379      P=0.500N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Ovary                                                                                                                            |
|     Cystadenoma                                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |                                                    |  1/75 (1%)    0/20 (0%)    3/64 (5%)    3/98 (3%)  |
|ADJUSTED (b)           |                                                    |   2.0%         0.0%         9.7%         4.7%      |
|TERMINAL (d)           |                                                    |  1/49 (2%)    0/12 (0%)    3/31 (10%)   2/59 (3%)  |
|FIRST INCIDENCE (DAYS) |                                                    |   740 (T)      ---          740 (T)      691       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                                                    |  P=0.338      P=0.777N     P=0.160      P=0.350    |
|INCIDENTAL TUMOR       |                                                    |  P=0.378      P=0.777N     P=0.160      P=0.418    |
|LOGISTIC REGRESSION    |                                                    |  P=0.382      P=0.777N     P=0.160      P=0.404    |
|COCHRAN-ARMITAGE       |                                                    |  P=0.374                                           |
|FISHER EXACT           |                                                    |               P=0.789N     P=0.253      P=0.417    |
|=================================================================================================================================|
 
         DATE: 09/10/94                     EXPERIMENT: 05076 TEST: 02                                                 PAGE  12
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ETHYLENETHIOUREA
 
                                                 MALE TERMINAL SACRIFICE AT 107 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 106 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 PPM        100 PPM      333 PPM      1000 PPM  |   0 PPM        100 PPM      333 PPM      1000 PPM  |
|                       |   10-0         1-1          10-3         10-10     |   10-0         1-1          10-3         10-10     |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/86 (0%)    0/28 (0%)    0/128 (0%)  12/80 (15%) | 21/95 (22%)   6/28 (21%)  59/144 (41%) 50/96 (52%) |
|ADJUSTED (b)           |   0.0%         0.0%         0.0%        23.7%      |  27.3%        28.6%        48.8%        66.0%      |
|TERMINAL (d)           |  0/54 (0%)    0/22 (0%)    0/93 (0%)    7/40 (18%) | 17/72 (24%)   6/21 (29%)  51/112 (46%) 35/60 (58%) |
|FIRST INCIDENCE (DAYS) |   ---          ---          ---          669       |   587          740 (T)      569          611       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P<0.001 **     (e)          (e)        P<0.001 ** |  P<0.001 **   P=0.591N     P=0.004 **   P<0.001 ** |
|INCIDENTAL TUMOR       |  P<0.001 **     (e)          (e)        P=0.001 ** |  P<0.001 **   P=0.559N     P=0.003 **   P<0.001 ** |
|LOGISTIC REGRESSION    |  P<0.001 **     (e)          (e)        P<0.001 ** |  P<0.001 **   P=0.595N     P=0.003 **   P<0.001 ** |
|COCHRAN-ARMITAGE       |  P<0.001 **                                        |  P<0.001 **                                        |
|FISHER EXACT           |                 (e)          (e)        P<0.001 ** |               P=0.583N     P=0.002 **   P<0.001 ** |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/86 (0%)    0/28 (0%)    0/128 (0%)  12/80 (15%) | 22/95 (23%)   7/28 (25%)  59/144 (41%) 50/96 (52%) |
|ADJUSTED (b)           |   0.0%         0.0%         0.0%        23.7%      |  28.6%        31.0%        48.8%        66.0%      |
|TERMINAL (d)           |  0/54 (0%)    0/22 (0%)    0/93 (0%)    7/40 (18%) | 18/72 (25%)   6/21 (29%)  51/112 (46%) 35/60 (58%) |
|FIRST INCIDENCE (DAYS) |   ---          ---          ---          669       |   587          359          569          611       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P<0.001 **     (e)          (e)        P<0.001 ** |  P<0.001 **   P=0.502      P=0.006 **   P<0.001 ** |
|INCIDENTAL TUMOR       |  P<0.001 **     (e)          (e)        P=0.001 ** |  P<0.001 **   P=0.586      P=0.006 **   P<0.001 ** |
|LOGISTIC REGRESSION    |  P<0.001 **     (e)          (e)        P<0.001 ** |  P<0.001 **   P=0.511      P=0.006 **   P<0.001 ** |
|COCHRAN-ARMITAGE       |  P<0.001 **                                        |  P<0.001 **                                        |
|FISHER EXACT           |                 (e)          (e)        P<0.001 ** |               P=0.511      P=0.003 **   P<0.001 ** |
|=================================================================================================================================|
 
         DATE: 09/10/94                     EXPERIMENT: 05076 TEST: 02                                                 PAGE  13
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ETHYLENETHIOUREA
 
                                                 MALE TERMINAL SACRIFICE AT 107 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 106 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 PPM        100 PPM      333 PPM      1000 PPM  |   0 PPM        100 PPM      333 PPM      1000 PPM  |
|                       |   10-0         1-1          10-3         10-10     |   10-0         1-1          10-3         10-10     |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Intermedia                                                                                                 |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/86 (1%)    0/28 (0%)    0/128 (0%)   1/80 (1%)  |  0/95 (0%)    2/28 (7%)    2/144 (1%)   0/96 (0%)  |
|ADJUSTED (b)           |   1.9%         0.0%         0.0%         2.5%      |   0.0%         9.5%         1.6%         0.0%      |
|TERMINAL (d)           |  1/54 (2%)    0/22 (0%)    0/93 (0%)    1/40 (3%)  |  0/72 (0%)    2/21 (10%)   1/112 (1%)   0/60 (0%)  |
|FIRST INCIDENCE (DAYS) |   743 (T)      ---          ---          743 (T)   |   ---          740 (T)      605          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.528      P=0.679N     P=0.392N     P=0.693    |  P=0.328N     P=0.037 *    P=0.346        (e)      |
|INCIDENTAL TUMOR       |  P=0.528      P=0.679N     P=0.392N     P=0.693    |  P=0.323N     P=0.037 *    P=0.261        (e)      |
|LOGISTIC REGRESSION    |  P=0.528      P=0.680N     P=0.392N     P=0.693    |  P=0.289N     P=0.037 *    P=0.281        (e)      |
|COCHRAN-ARMITAGE       |  P=0.584                                           |  P=0.291N                                          |
|FISHER EXACT           |               P=0.754N     P=0.402N     P=0.733    |               P=0.050      P=0.362        (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Squamous Cell Carcinoma, Papilloma Squamous, or Papilloma                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/99 (0%)    0/33 (0%)    2/149 (1%)   1/100 (1%) |  0/100 (0%)   0/29 (0%)    0/150 (0%)   1/100 (1%) |
|ADJUSTED (b)           |   0.0%         0.0%         1.8%         2.1%      |   0.0%         0.0%         0.0%         1.7%      |
|TERMINAL (d)           |  0/58 (0%)    0/26 (0%)    1/95 (1%)    1/48 (2%)  |  0/73 (0%)    0/21 (0%)    0/115 (0%)   1/60 (2%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          622          743 (T)   |   ---          ---          ---          740 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.380        (e)        P=0.364      P=0.462    |  P=0.210        (e)          (e)        P=0.461    |
|INCIDENTAL TUMOR       |  P=0.395        (e)        P=0.367      P=0.462    |  P=0.210        (e)          (e)        P=0.461    |
|LOGISTIC REGRESSION    |  P=0.433        (e)        P=0.348      P=0.462    |  P=0.210        (e)          (e)        P=0.461    |
|COCHRAN-ARMITAGE       |  P=0.423                                           |  P=0.245                                           |
|FISHER EXACT           |                 (e)        P=0.360      P=0.503    |                 (e)          (e)        P=0.500    |
|=================================================================================================================================|
 
         DATE: 09/10/94                     EXPERIMENT: 05076 TEST: 02                                                 PAGE  14
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ETHYLENETHIOUREA
 
                                                 MALE TERMINAL SACRIFICE AT 107 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 106 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 PPM        100 PPM      333 PPM      1000 PPM  |   0 PPM        100 PPM      333 PPM      1000 PPM  |
|                       |   10-0         1-1          10-3         10-10     |   10-0         1-1          10-3         10-10     |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Trichoepithelioma, Kertatocanthoma, Squamous Cell Carcinoma,                                                                |
|     Basal Cell Carcinoma or Adenoma, Papilloma Squamous, or Papilloma                                                           |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/99 (0%)    0/33 (0%)    2/149 (1%)   1/100 (1%) |  0/100 (0%)   0/29 (0%)    0/150 (0%)   1/100 (1%) |
|ADJUSTED (b)           |   0.0%         0.0%         1.8%         2.1%      |   0.0%         0.0%         0.0%         1.7%      |
|TERMINAL (d)           |  0/58 (0%)    0/26 (0%)    1/95 (1%)    1/48 (2%)  |  0/73 (0%)    0/21 (0%)    0/115 (0%)   1/60 (2%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          622          743 (T)   |   ---          ---          ---          740 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.380        (e)        P=0.364      P=0.462    |  P=0.210        (e)          (e)        P=0.461    |
|INCIDENTAL TUMOR       |  P=0.395        (e)        P=0.367      P=0.462    |  P=0.210        (e)          (e)        P=0.461    |
|LOGISTIC REGRESSION    |  P=0.433        (e)        P=0.348      P=0.462    |  P=0.210        (e)          (e)        P=0.461    |
|COCHRAN-ARMITAGE       |  P=0.423                                           |  P=0.245                                           |
|FISHER EXACT           |                 (e)        P=0.360      P=0.503    |                 (e)          (e)        P=0.500    |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin: Subcutaneous Tissue                                                                                                        |
|     Fibrosarcoma                                                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  6/99 (6%)    4/33 (12%)  21/149 (14%) 10/100 (10%)|  2/100 (2%)   0/29 (0%)    1/150 (1%)   1/100 (1%) |
|ADJUSTED (b)           |   9.1%        13.9%        19.1%        13.5%      |   2.3%         0.0%         0.8%         1.7%      |
|TERMINAL (d)           |  1/58 (2%)    2/26 (8%)   11/95 (12%)   1/48 (2%)  |  0/73 (0%)    0/21 (0%)    0/115 (0%)   1/60 (2%)  |
|FIRST INCIDENCE (DAYS) |   578          516          576          525       |   487          ---          738          740 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.298      P=0.355      P=0.079      P=0.240    |  P=0.576N     P=0.540N     P=0.346N     P=0.543N   |
|INCIDENTAL TUMOR       |  P=0.268N     P=0.149      P=0.139      P=0.497N   |  P=0.452N     P=0.643N     P=0.425N     P=0.488N   |
|LOGISTIC REGRESSION    |  P=0.365N     P=0.269      P=0.117      P=0.590    |  P=0.498N     P=0.506N     P=0.466N     P=0.474N   |
|COCHRAN-ARMITAGE       |  P=0.397                                           |  P=0.528N                                          |
|FISHER EXACT           |               P=0.217      P=0.035 *    P=0.224    |               P=0.600N     P=0.351N     P=0.500N   |
|=================================================================================================================================|
 
         DATE: 09/10/94                     EXPERIMENT: 05076 TEST: 02                                                 PAGE  15
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ETHYLENETHIOUREA
 
                                                 MALE TERMINAL SACRIFICE AT 107 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 106 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 PPM        100 PPM      333 PPM      1000 PPM  |   0 PPM        100 PPM      333 PPM      1000 PPM  |
|                       |   10-0         1-1          10-3         10-10     |   10-0         1-1          10-3         10-10     |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin: Subcutaneous Tissue                                                                                                        |
|     Fibrous Histiocytoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/99 (1%)    1/33 (3%)    2/149 (1%)   0/100 (0%) |  0/100 (0%)   0/29 (0%)    0/150 (0%)   0/100 (0%) |
|ADJUSTED (b)           |   1.7%         3.8%         2.1%         0.0%      |   0.0%         0.0%         0.0%         0.0%      |
|TERMINAL (d)           |  1/58 (2%)    1/26 (4%)    2/95 (2%)    0/48 (0%)  |  0/73 (0%)    0/21 (0%)    0/115 (0%)   0/60 (0%)  |
|FIRST INCIDENCE (DAYS) |   743 (T)      743 (T)      743 (T)      ---       |   ---          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.311N     P=0.573      P=0.668      P=0.538N   |    (e)          (e)          (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.311N     P=0.573      P=0.668      P=0.538N   |    (e)          (e)          (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.311N     P=0.573      P=0.668      P=0.538N   |    (e)          (e)          (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.253N                                          |    (e)                                             |
|FISHER EXACT           |               P=0.439      P=0.650      P=0.497N   |                 (e)          (e)          (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin: Subcutaneous Tissue                                                                                                        |
|     Hemangiosarcoma                                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/99 (0%)    0/33 (0%)    0/149 (0%)   0/100 (0%) |  2/100 (2%)   0/29 (0%)    0/150 (0%)   0/100 (0%) |
|ADJUSTED (b)           |   0.0%         0.0%         0.0%         0.0%      |   2.3%         0.0%         0.0%         0.0%      |
|TERMINAL (d)           |  0/58 (0%)    0/26 (0%)    0/95 (0%)    0/48 (0%)  |  0/73 (0%)    0/21 (0%)    0/115 (0%)   0/60 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          ---          ---       |   609          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |    (e)          (e)          (e)          (e)      |  P=0.190N     P=0.549N     P=0.144N     P=0.242N   |
|INCIDENTAL TUMOR       |    (e)          (e)          (e)          (e)      |  P=0.143N     P=0.486N     P=0.179N     P=0.144N   |
|LOGISTIC REGRESSION    |    (e)          (e)          (e)          (e)      |  P=0.162N     P=0.516N     P=0.215N     P=0.214N   |
|COCHRAN-ARMITAGE       |    (e)                                             |  P=0.190N                                          |
|FISHER EXACT           |                 (e)          (e)          (e)      |               P=0.600N     P=0.159N     P=0.249N   |
|=================================================================================================================================|
 
         DATE: 09/10/94                     EXPERIMENT: 05076 TEST: 02                                                 PAGE  16
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ETHYLENETHIOUREA
 
                                                 MALE TERMINAL SACRIFICE AT 107 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 106 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 PPM        100 PPM      333 PPM      1000 PPM  |   0 PPM        100 PPM      333 PPM      1000 PPM  |
|                       |   10-0         1-1          10-3         10-10     |   10-0         1-1          10-3         10-10     |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin: Subcutaneous Tissue                                                                                                        |
|     Neurofibrosarcoma                                                                                                           |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/99 (0%)    0/33 (0%)    2/149 (1%)   0/100 (0%) |  0/100 (0%)   0/29 (0%)    0/150 (0%)   0/100 (0%) |
|ADJUSTED (b)           |   0.0%         0.0%         2.1%         0.0%      |   0.0%         0.0%         0.0%         0.0%      |
|TERMINAL (d)           |  0/58 (0%)    0/26 (0%)    2/95 (2%)    0/48 (0%)  |  0/73 (0%)    0/21 (0%)    0/115 (0%)   0/60 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          743 (T)      ---       |   ---          ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.707N       (e)        P=0.353        (e)      |    (e)          (e)          (e)          (e)      |
|INCIDENTAL TUMOR       |  P=0.707N       (e)        P=0.353        (e)      |    (e)          (e)          (e)          (e)      |
|LOGISTIC REGRESSION    |  P=0.707N       (e)        P=0.353        (e)      |    (e)          (e)          (e)          (e)      |
|COCHRAN-ARMITAGE       |  P=0.643N                                          |    (e)                                             |
|FISHER EXACT           |                 (e)        P=0.360        (e)      |                 (e)          (e)          (e)      |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin: Subcutaneous Tissue                                                                                                        |
|     Neurofibrosarcoma, Fibrosarcoma, Sarcoma,                                                                                   |
|     Neurofibroma, or Fibroma                                                                                                    |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 10/99 (10%)   5/33 (15%)  27/149 (18%) 12/100 (12%)|  2/100 (2%)   0/29 (0%)    2/150 (1%)   1/100 (1%) |
|ADJUSTED (b)           |  14.6%        17.4%        24.1%        16.4%      |   2.3%         0.0%         1.7%         1.7%      |
|TERMINAL (d)           |  2/58 (3%)    3/26 (12%)  14/95 (15%)   2/48 (4%)  |  0/73 (0%)    0/21 (0%)    1/115 (1%)   1/60 (2%)  |
|FIRST INCIDENCE (DAYS) |   565          516          576          525       |   487          ---          738          740 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.441      P=0.486      P=0.132      P=0.429    |  P=0.549N     P=0.540N     P=0.522N     P=0.543N   |
|INCIDENTAL TUMOR       |  P=0.098N     P=0.193      P=0.252      P=0.210N   |  P=0.438N     P=0.643N     P=0.601N     P=0.488N   |
|LOGISTIC REGRESSION    |  P=0.158N     P=0.341      P=0.208      P=0.292N   |  P=0.473N     P=0.506N     P=0.621N     P=0.474N   |
|COCHRAN-ARMITAGE       |  P=0.523N                                          |  P=0.492N                                          |
|FISHER EXACT           |               P=0.307      P=0.058      P=0.421    |               P=0.600N     P=0.525N     P=0.500N   |
|=================================================================================================================================|
 
         DATE: 09/10/94                     EXPERIMENT: 05076 TEST: 02                                                 PAGE  17
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ETHYLENETHIOUREA
 
                                                 MALE TERMINAL SACRIFICE AT 107 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 106 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 PPM        100 PPM      333 PPM      1000 PPM  |   0 PPM        100 PPM      333 PPM      1000 PPM  |
|                       |   10-0         1-1          10-3         10-10     |   10-0         1-1          10-3         10-10     |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin: Subcutaneous Tissue                                                                                                        |
|     Neurofibrosarcoma, Fibrosarcoma, or Sarcoma                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  9/99 (9%)    5/33 (15%)  27/149 (18%) 12/100 (12%)|  2/100 (2%)   0/29 (0%)    2/150 (1%)   1/100 (1%) |
|ADJUSTED (b)           |  13.1%        17.4%        24.1%        16.4%      |   2.3%         0.0%         1.7%         1.7%      |
|TERMINAL (d)           |  1/58 (2%)    3/26 (12%)  14/95 (15%)   2/48 (4%)  |  0/73 (0%)    0/21 (0%)    1/115 (1%)   1/60 (2%)  |
|FIRST INCIDENCE (DAYS) |   565          516          576          525       |   487          ---          738          740 (T)   |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.386      P=0.413      P=0.089      P=0.351    |  P=0.549N     P=0.540N     P=0.522N     P=0.543N   |
|INCIDENTAL TUMOR       |  P=0.124N     P=0.125      P=0.176      P=0.278N   |  P=0.438N     P=0.643N     P=0.601N     P=0.488N   |
|LOGISTIC REGRESSION    |  P=0.197N     P=0.259      P=0.141      P=0.387N   |  P=0.473N     P=0.506N     P=0.621N     P=0.474N   |
|COCHRAN-ARMITAGE       |  P=0.518                                           |  P=0.492N                                          |
|FISHER EXACT           |               P=0.249      P=0.034 *    P=0.332    |               P=0.600N     P=0.525N     P=0.500N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin: Subcutaneous Tissue                                                                                                        |
|     Sarcoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  3/99 (3%)    1/33 (3%)    4/149 (3%)   2/100 (2%) |  0/100 (0%)   0/29 (0%)    1/150 (1%)   0/100 (0%) |
|ADJUSTED (b)           |   4.4%         3.8%         3.8%         3.2%      |   0.0%         0.0%         0.9%         0.0%      |
|TERMINAL (d)           |  0/58 (0%)    1/26 (4%)    1/95 (1%)    1/48 (2%)  |  0/73 (0%)    0/21 (0%)    1/115 (1%)   0/60 (0%)  |
|FIRST INCIDENCE (DAYS) |   565          743 (T)      693          618       |   ---          ---          740 (T)      ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.471N     P=0.644N     P=0.526N     P=0.487N   |  P=0.790N       (e)        P=0.591        (e)      |
|INCIDENTAL TUMOR       |  P=0.185N     P=0.621      P=0.368N     P=0.286N   |  P=0.790N       (e)        P=0.591        (e)      |
|LOGISTIC REGRESSION    |  P=0.401N     P=0.691N     P=0.555N     P=0.477N   |  P=0.790N       (e)        P=0.591        (e)      |
|COCHRAN-ARMITAGE       |  P=0.417N                                          |  P=0.755N                                          |
|FISHER EXACT           |               P=0.740N     P=0.580N     P=0.495N   |                 (e)        P=0.600        (e)      |
|=================================================================================================================================|
 
         DATE: 09/10/94                     EXPERIMENT: 05076 TEST: 02                                                 PAGE  18
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ETHYLENETHIOUREA
 
                                                 MALE TERMINAL SACRIFICE AT 107 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 106 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 PPM        100 PPM      333 PPM      1000 PPM  |   0 PPM        100 PPM      333 PPM      1000 PPM  |
|                       |   10-0         1-1          10-3         10-10     |   10-0         1-1          10-3         10-10     |
|=================================================================================================================================|
|                                                                                                                                 |
|Spleen                                                                                                                           |
|     Hemangiosarcoma                                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/74 (1%)    0/12 (0%)    1/69 (1%)    3/95 (3%)  |  2/73 (3%)    0/13 (0%)    5/93 (5%)    2/99 (2%)  |
|ADJUSTED (b)           |   2.9%         0.0%         0.9%         5.8%      |   2.3%         0.0%         6.6%         3.2%      |
|TERMINAL (d)           |  1/35 (3%)    0/5 (0%)     0/20 (0%)    2/47 (4%)  |  0/46 (0%)    0/5 (0%)     3/58 (5%)    1/59 (2%)  |
|FIRST INCIDENCE (DAYS) |   743 (T)      ---          690          694       |   609          ---          621          709       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.229      P=0.872N     P=0.767N     P=0.389    |  P=0.556N     P=0.549N     P=0.391      P=0.684N   |
|INCIDENTAL TUMOR       |  P=0.365      P=0.872N     P=0.737N     P=0.485    |  P=0.404N     P=0.486N     P=0.327      P=0.521N   |
|LOGISTIC REGRESSION    |  P=0.347      P=0.872N     P=0.755      P=0.478    |  P=0.417N     P=0.606N     P=0.313      P=0.580N   |
|COCHRAN-ARMITAGE       |  P=0.258                                           |  P=0.418N                                          |
|FISHER EXACT           |               P=0.860N     P=0.734      P=0.409    |               P=0.719N     P=0.333      P=0.568N   |
|=================================================================================================================================|
|                                                                                                                                 |
|Stomach, Forestomach                                                                                                             |
|     Squamous Cell Papilloma                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/99 (2%)    0/33 (0%)    2/149 (1%)   0/100 (0%) |  2/100 (2%)   0/29 (0%)    2/150 (1%)   0/100 (0%) |
|ADJUSTED (b)           |   3.4%         0.0%         2.1%         0.0%      |   2.7%         0.0%         1.7%         0.0%      |
|TERMINAL (d)           |  2/58 (3%)    0/26 (0%)    2/95 (2%)    0/48 (0%)  |  2/73 (3%)    0/21 (0%)    2/115 (2%)   0/60 (0%)  |
|FIRST INCIDENCE (DAYS) |   743 (T)      ---          743 (T)      ---       |   740 (T)      ---          740 (T)      ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.263N     P=0.427N     P=0.507N     P=0.281N   |  P=0.247N     P=0.536N     P=0.522N     P=0.283N   |
|INCIDENTAL TUMOR       |  P=0.263N     P=0.427N     P=0.507N     P=0.281N   |  P=0.247N     P=0.536N     P=0.522N     P=0.283N   |
|LOGISTIC REGRESSION    |  P=0.263N     P=0.427N     P=0.507N     P=0.281N   |  P=0.247N     P=0.536N     P=0.522N     P=0.283N   |
|COCHRAN-ARMITAGE       |  P=0.212N                                          |  P=0.210N                                          |
|FISHER EXACT           |               P=0.561N     P=0.524N     P=0.246N   |               P=0.600N     P=0.525N     P=0.249N   |
|=================================================================================================================================|
 
         DATE: 09/10/94                     EXPERIMENT: 05076 TEST: 02                                                 PAGE  19
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ETHYLENETHIOUREA
 
                                                 MALE TERMINAL SACRIFICE AT 107 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 106 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 PPM        100 PPM      333 PPM      1000 PPM  |   0 PPM        100 PPM      333 PPM      1000 PPM  |
|                       |   10-0         1-1          10-3         10-10     |   10-0         1-1          10-3         10-10     |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicular Cell                                                                                                   |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/96 (1%)    1/33 (3%)    4/144 (3%)  59/99 (60%) |  1/99 (1%)    1/29 (3%)   17/149 (11%) 73/100 (73%)|
|ADJUSTED (b)           |   1.8%         3.8%         4.2%        75.9%      |   1.4%         4.8%        14.6%        87.7%      |
|TERMINAL (d)           |  1/55 (2%)    1/26 (4%)    4/95 (4%)   30/48 (63%) |  1/72 (1%)    1/21 (5%)   16/115 (14%) 50/60 (83%) |
|FIRST INCIDENCE (DAYS) |   743 (T)      743 (T)      743 (T)      241       |   740 (T)      740 (T)      710          598       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P<0.001 **   P=0.586      P=0.377      P<0.001 ** |  P<0.001 **   P=0.467      P=0.003 **   P<0.001 ** |
|INCIDENTAL TUMOR       |  P<0.001 **   P=0.586      P=0.377      P<0.001 ** |  P<0.001 **   P=0.467      P=0.003 **   P<0.001 ** |
|LOGISTIC REGRESSION    |  P<0.001 **   P=0.586      P=0.377      P<0.001 ** |  P<0.001 **   P=0.467      P=0.003 **   P<0.001 ** |
|COCHRAN-ARMITAGE       |  P<0.001 **                                        |  P<0.001 **                                        |
|FISHER EXACT           |               P=0.448      P=0.335      P<0.001 ** |               P=0.403      P<0.001 **   P<0.001 ** |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicular Cell                                                                                                   |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/96 (1%)    0/33 (0%)    0/144 (0%)  14/99 (14%) |  0/99 (0%)    0/29 (0%)    1/149 (1%)  12/100 (12%)|
|ADJUSTED (b)           |   1.8%         0.0%         0.0%        24.5%      |   0.0%         0.0%         0.9%        17.9%      |
|TERMINAL (d)           |  1/55 (2%)    0/26 (0%)    0/95 (0%)    8/48 (17%) |  0/72 (0%)    0/21 (0%)    1/115 (1%)   8/60 (13%) |
|FIRST INCIDENCE (DAYS) |   743 (T)      ---          ---          669       |   ---          ---          740 (T)      674       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P<0.001 **   P=0.649N     P=0.391N     P<0.001 ** |  P<0.001 **     (e)        P=0.593      P<0.001 ** |
|INCIDENTAL TUMOR       |  P<0.001 **   P=0.649N     P=0.391N     P=0.003 ** |  P<0.001 **     (e)        P=0.593      P<0.001 ** |
|LOGISTIC REGRESSION    |  P<0.001 **   P=0.649N     P=0.391N     P=0.001 ** |  P<0.001 **     (e)        P=0.593      P<0.001 ** |
|COCHRAN-ARMITAGE       |  P<0.001 **                                        |  P<0.001 **                                        |
|FISHER EXACT           |               P=0.744N     P=0.400N     P<0.001 ** |                 (e)        P=0.601      P<0.001 ** |
|=================================================================================================================================|
 
         DATE: 09/10/94                     EXPERIMENT: 05076 TEST: 02                                                 PAGE  20
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ETHYLENETHIOUREA
 
                                                 MALE TERMINAL SACRIFICE AT 107 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 106 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 PPM        100 PPM      333 PPM      1000 PPM  |   0 PPM        100 PPM      333 PPM      1000 PPM  |
|                       |   10-0         1-1          10-3         10-10     |   10-0         1-1          10-3         10-10     |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: Follicular Cell                                                                                                   |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  2/96 (2%)    1/33 (3%)    4/144 (3%)  64/99 (65%) |  1/99 (1%)    1/29 (3%)   17/149 (11%) 76/100 (76%)|
|ADJUSTED (b)           |   3.6%         3.8%         4.2%        82.6%      |   1.4%         4.8%        14.6%        90.3%      |
|TERMINAL (d)           |  2/55 (4%)    1/26 (4%)    4/95 (4%)   35/48 (73%) |  1/72 (1%)    1/21 (5%)   16/115 (14%) 52/60 (87%) |
|FIRST INCIDENCE (DAYS) |   743 (T)      743 (T)      743 (T)      241       |   740 (T)      740 (T)      710          598       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P<0.001 **   P=0.719      P=0.602      P<0.001 ** |  P<0.001 **   P=0.467      P=0.003 **   P<0.001 ** |
|INCIDENTAL TUMOR       |  P<0.001 **   P=0.719      P=0.602      P<0.001 ** |  P<0.001 **   P=0.467      P=0.003 **   P<0.001 ** |
|LOGISTIC REGRESSION    |  P<0.001 **   P=0.719      P=0.602      P<0.001 ** |  P<0.001 **   P=0.467      P=0.003 **   P<0.001 ** |
|COCHRAN-ARMITAGE       |  P<0.001 **                                        |  P<0.001 **                                        |
|FISHER EXACT           |               P=0.591      P=0.544      P<0.001 ** |               P=0.403      P<0.001 **   P<0.001 ** |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Hemangioma                                                                                                                  |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/99 (0%)    0/33 (0%)    1/149 (1%)   3/100 (3%) |  2/100 (2%)   0/29 (0%)    0/150 (0%)   0/100 (0%) |
|ADJUSTED (b)           |   0.0%         0.0%         0.8%         5.8%      |   2.7%         0.0%         0.0%         0.0%      |
|TERMINAL (d)           |  0/58 (0%)    0/26 (0%)    0/95 (0%)    2/48 (4%)  |  2/73 (3%)    0/21 (0%)    0/115 (0%)   0/60 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          662          700       |   740 (T)      ---          ---          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.021 *      (e)        P=0.615      P=0.098    |  P=0.210N     P=0.536N     P=0.146N     P=0.283N   |
|INCIDENTAL TUMOR       |  P=0.065        (e)        P=0.693      P=0.151    |  P=0.210N     P=0.536N     P=0.146N     P=0.283N   |
|LOGISTIC REGRESSION    |  P=0.034 *      (e)        P=0.589      P=0.132    |  P=0.210N     P=0.536N     P=0.146N     P=0.283N   |
|COCHRAN-ARMITAGE       |  P=0.033 *                                         |  P=0.190N                                          |
|FISHER EXACT           |                 (e)        P=0.601      P=0.125    |               P=0.600N     P=0.159N     P=0.249N   |
|=================================================================================================================================|
 
         DATE: 09/10/94                     EXPERIMENT: 05076 TEST: 02                                                 PAGE  21
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ETHYLENETHIOUREA
 
                                                 MALE TERMINAL SACRIFICE AT 107 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 106 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 PPM        100 PPM      333 PPM      1000 PPM  |   0 PPM        100 PPM      333 PPM      1000 PPM  |
|                       |   10-0         1-1          10-3         10-10     |   10-0         1-1          10-3         10-10     |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Hemangiosarcoma                                                                                                             |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  5/99 (5%)    1/33 (3%)    7/149 (5%)   7/100 (7%) |  5/100 (5%)   0/29 (0%)   11/150 (7%)   4/100 (4%) |
|ADJUSTED (b)           |   8.1%         3.8%         6.7%        12.4%      |   6.3%         0.0%         8.9%         6.4%      |
|TERMINAL (d)           |  4/58 (7%)    1/26 (4%)    4/95 (4%)    4/48 (8%)  |  3/73 (4%)    0/21 (0%)    7/115 (6%)   3/60 (5%)  |
|FIRST INCIDENCE (DAYS) |   565          743 (T)      623          685       |   609          ---          605          709       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.159      P=0.386N     P=0.496N     P=0.319    |  P=0.567      P=0.257N     P=0.361      P=0.590N   |
|INCIDENTAL TUMOR       |  P=0.343      P=0.393N     P=0.448N     P=0.482    |  P=0.444N     P=0.231N     P=0.297      P=0.474N   |
|LOGISTIC REGRESSION    |  P=0.280      P=0.426N     P=0.480N     P=0.454    |  P=0.492N     P=0.247N     P=0.298      P=0.512N   |
|COCHRAN-ARMITAGE       |  P=0.260                                           |  P=0.483N                                          |
|FISHER EXACT           |               P=0.532N     P=0.562N     P=0.391    |               P=0.274N     P=0.323      P=0.500N   |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Hemangiosarcoma or Hemangioma                                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  5/99 (5%)    1/33 (3%)    8/149 (5%)  10/100 (10%)|  7/100 (7%)   0/29 (0%)   11/150 (7%)   4/100 (4%) |
|ADJUSTED (b)           |   8.1%         3.8%         7.5%        17.8%      |   9.0%         0.0%         8.9%         6.4%      |
|TERMINAL (d)           |  4/58 (7%)    1/26 (4%)    4/95 (4%)    6/48 (13%) |  5/73 (7%)    0/21 (0%)    7/115 (6%)   3/60 (5%)  |
|FIRST INCIDENCE (DAYS) |   565          743 (T)      623          685       |   609          ---          605          709       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.025 *    P=0.386N     P=0.579N     P=0.100    |  P=0.417N     P=0.166N     P=0.590N     P=0.363N   |
|INCIDENTAL TUMOR       |  P=0.114      P=0.393N     P=0.515N     P=0.214    |  P=0.286N     P=0.150N     P=0.546      P=0.267N   |
|LOGISTIC REGRESSION    |  P=0.068      P=0.426N     P=0.573N     P=0.189    |  P=0.317N     P=0.161N     P=0.552      P=0.283N   |
|COCHRAN-ARMITAGE       |  P=0.061                                           |  P=0.307N                                          |
|FISHER EXACT           |               P=0.532N     P=0.578      P=0.146    |               P=0.160N     P=0.565      P=0.269N   |
|=================================================================================================================================|
 
         DATE: 09/10/94                     EXPERIMENT: 05076 TEST: 02                                                 PAGE  22
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ETHYLENETHIOUREA
 
                                                 MALE TERMINAL SACRIFICE AT 107 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 106 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 PPM        100 PPM      333 PPM      1000 PPM  |   0 PPM        100 PPM      333 PPM      1000 PPM  |
|                       |   10-0         1-1          10-3         10-10     |   10-0         1-1          10-3         10-10     |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Histiocytic Sarcoma                                                                                                         |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  1/99 (1%)    1/33 (3%)    4/149 (3%)   2/100 (2%) |  0/100 (0%)   1/29 (3%)    5/150 (3%)   4/100 (4%) |
|ADJUSTED (b)           |   1.7%         3.8%         3.3%         3.2%      |   0.0%         4.3%         3.6%         5.3%      |
|TERMINAL (d)           |  1/58 (2%)    1/26 (4%)    0/95 (0%)    0/48 (0%)  |  0/73 (0%)    0/21 (0%)    1/115 (1%)   1/60 (2%)  |
|FIRST INCIDENCE (DAYS) |   743 (T)      743 (T)      536          582       |   ---          668          529          570       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.503      P=0.573      P=0.385      P=0.479    |  P=0.102      P=0.248      P=0.096      P=0.056    |
|INCIDENTAL TUMOR       |  P=0.504N     P=0.573      P=0.440      P=0.627    |  P=0.229      P=0.212      P=0.046 *    P=0.097    |
|LOGISTIC REGRESSION    |  P=0.547      P=0.573      P=0.327      P=0.530    |  P=0.199      P=0.262      P=0.028 *    P=0.071    |
|COCHRAN-ARMITAGE       |  P=0.542                                           |  P=0.120                                           |
|FISHER EXACT           |               P=0.439      P=0.336      P=0.504    |               P=0.225      P=0.076      P=0.061    |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant Lymphoma And Histiocytic Sarcoma                                                                                  |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 14/99 (14%)   5/33 (15%)  26/149 (17%) 15/100 (15%)| 37/100 (37%)  9/29 (31%)  58/150 (39%) 32/100 (32%)|
|ADJUSTED (b)           |  21.5%        19.2%        22.5%        22.1%      |  42.5%        35.4%        42.5%        42.7%      |
|TERMINAL (d)           | 10/58 (17%)   5/26 (19%)  12/95 (13%)   3/48 (6%)  | 24/73 (33%)   5/21 (24%)  38/115 (33%) 20/60 (33%) |
|FIRST INCIDENCE (DAYS) |   180          743 (T)      536          522       |   327          552          529          443       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.370      P=0.443N     P=0.454      P=0.443    |  P=0.488      P=0.391N     P=0.532N     P=0.545    |
|INCIDENTAL TUMOR       |  P=0.221N     P=0.495N     P=0.540      P=0.329N   |  P=0.150N     P=0.317N     P=0.502      P=0.229N   |
|LOGISTIC REGRESSION    |  P=0.378N     P=0.573N     P=0.392      P=0.580N   |  P=0.250N     P=0.344N     P=0.385      P=0.276N   |
|COCHRAN-ARMITAGE       |  P=0.538                                           |  P=0.259N                                          |
|FISHER EXACT           |               P=0.543      P=0.305      P=0.512    |               P=0.360N     P=0.448      P=0.276N   |
|=================================================================================================================================|
 
         DATE: 09/10/94                     EXPERIMENT: 05076 TEST: 02                                                 PAGE  23
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ETHYLENETHIOUREA
 
                                                 MALE TERMINAL SACRIFICE AT 107 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 106 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 PPM        100 PPM      333 PPM      1000 PPM  |   0 PPM        100 PPM      333 PPM      1000 PPM  |
|                       |   10-0         1-1          10-3         10-10     |   10-0         1-1          10-3         10-10     |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant Lymphoma: Histiocytic, Lymphocytic, Mixed,                                                                        |
|     NOS, or Undifferentiated Cell Type                                                                                          |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 13/99 (13%)   4/33 (12%)  22/149 (15%) 13/100 (13%)| 37/100 (37%)  8/29 (28%)  53/150 (35%) 28/100 (28%)|
|ADJUSTED (b)           |  19.9%        15.4%        19.8%        19.6%      |  42.5%        32.5%        40.1%        39.1%      |
|TERMINAL (d)           |  9/58 (16%)   4/26 (15%)  12/95 (13%)   3/48 (6%)  | 24/73 (33%)   5/21 (24%)  37/115 (32%) 19/60 (32%) |
|FIRST INCIDENCE (DAYS) |   180          743 (T)      619          522       |   327          552          647          443       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P=0.410      P=0.359N     P=0.569      P=0.528    |  P=0.387N     P=0.276N     P=0.349N     P=0.337N   |
|INCIDENTAL TUMOR       |  P=0.247N     P=0.407N     P=0.511N     P=0.286N   |  P=0.078N     P=0.202N     P=0.359N     P=0.100N   |
|LOGISTIC REGRESSION    |  P=0.485N     P=0.480N     P=0.533      P=0.511N   |  P=0.129N     P=0.228N     P=0.469N     P=0.117N   |
|COCHRAN-ARMITAGE       |  P=0.529N                                          |  P=0.125N                                          |
|FISHER EXACT           |               P=0.574N     P=0.434      P=0.572N   |               P=0.239N     P=0.446N     P=0.114N   |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Osteosarcoma                                                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/99 (0%)    0/33 (0%)    0/149 (0%)   0/100 (0%) |  2/100 (2%)   0/29 (0%)    1/150 (1%)   0/100 (0%) |
|ADJUSTED (b)           |   0.0%         0.0%         0.0%         0.0%      |   2.5%         0.0%         0.7%         0.0%      |
|TERMINAL (d)           |  0/58 (0%)    0/26 (0%)    0/95 (0%)    0/48 (0%)  |  1/73 (1%)    0/21 (0%)    0/115 (0%)   0/60 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          ---          ---       |   642          ---          625          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |    (e)          (e)          (e)          (e)      |  P=0.214N     P=0.541N     P=0.337N     P=0.263N   |
|INCIDENTAL TUMOR       |    (e)          (e)          (e)          (e)      |  P=0.189N     P=0.464N     P=0.490N     P=0.228N   |
|LOGISTIC REGRESSION    |    (e)          (e)          (e)          (e)      |  P=0.187N     P=0.531N     P=0.431N     P=0.236N   |
|COCHRAN-ARMITAGE       |    (e)                                             |  P=0.205N                                          |
|FISHER EXACT           |                 (e)          (e)          (e)      |               P=0.600N     P=0.351N     P=0.249N   |
|=================================================================================================================================|
 
         DATE: 09/10/94                     EXPERIMENT: 05076 TEST: 02                                                 PAGE  24
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ETHYLENETHIOUREA
 
                                                 MALE TERMINAL SACRIFICE AT 107 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 106 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 PPM        100 PPM      333 PPM      1000 PPM  |   0 PPM        100 PPM      333 PPM      1000 PPM  |
|                       |   10-0         1-1          10-3         10-10     |   10-0         1-1          10-3         10-10     |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Osteosarcoma or Osteoma                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |  0/99 (0%)    0/33 (0%)    0/149 (0%)   0/100 (0%) |  2/100 (2%)   0/29 (0%)    1/150 (1%)   0/100 (0%) |
|ADJUSTED (b)           |   0.0%         0.0%         0.0%         0.0%      |   2.5%         0.0%         0.7%         0.0%      |
|TERMINAL (d)           |  0/58 (0%)    0/26 (0%)    0/95 (0%)    0/48 (0%)  |  1/73 (1%)    0/21 (0%)    0/115 (0%)   0/60 (0%)  |
|FIRST INCIDENCE (DAYS) |   ---          ---          ---          ---       |   642          ---          625          ---       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |    (e)          (e)          (e)          (e)      |  P=0.214N     P=0.541N     P=0.337N     P=0.263N   |
|INCIDENTAL TUMOR       |    (e)          (e)          (e)          (e)      |  P=0.189N     P=0.464N     P=0.490N     P=0.228N   |
|LOGISTIC REGRESSION    |    (e)          (e)          (e)          (e)      |  P=0.187N     P=0.531N     P=0.431N     P=0.236N   |
|COCHRAN-ARMITAGE       |    (e)                                             |  P=0.205N                                          |
|FISHER EXACT           |                 (e)          (e)          (e)      |               P=0.600N     P=0.351N     P=0.249N   |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Benign Tumors                                                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 30/99 (30%)  15/33 (45%)  78/149 (52%) 77/100 (77%)| 36/100 (36%)  9/29 (31%) 126/150 (84%) 84/100 (84%)|
|ADJUSTED (b)           |  45.5%        55.4%        68.5%        91.4%      |  44.1%        42.9%        89.3%        96.5%      |
|TERMINAL (d)           | 23/58 (40%)  14/26 (54%)  60/95 (63%)  41/48 (85%) | 28/73 (38%)   9/21 (43%) 100/115 (87%) 57/60 (95%) |
|FIRST INCIDENCE (DAYS) |   351          532          526          241       |   491          740 (T)      503          443       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P<0.001 **   P=0.377      P=0.005 **   P<0.001 ** |  P<0.001 **   P=0.413N     P<0.001 **   P<0.001 ** |
|INCIDENTAL TUMOR       |  P<0.001 **   P=0.258      P=0.006 **   P<0.001 ** |  P<0.001 **   P=0.437N     P<0.001 **   P<0.001 ** |
|LOGISTIC REGRESSION    |  P<0.001 **   P=0.231      P=0.007 **   P<0.001 ** |  P<0.001 **   P=0.432N     P<0.001 **   P<0.001 ** |
|COCHRAN-ARMITAGE       |  P<0.001 **                                        |  P<0.001 **                                        |
|FISHER EXACT           |               P=0.085      P<0.001 **   P<0.001 ** |               P=0.397N     P<0.001 **   P<0.001 ** |
|=================================================================================================================================|
 
         DATE: 09/10/94                     EXPERIMENT: 05076 TEST: 02                                                 PAGE  25
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ETHYLENETHIOUREA
 
                                                 MALE TERMINAL SACRIFICE AT 107 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 106 WEEKS
 
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |   0 PPM        100 PPM      333 PPM      1000 PPM  |   0 PPM        100 PPM      333 PPM      1000 PPM  |
|                       |   10-0         1-1          10-3         10-10     |   10-0         1-1          10-3         10-10     |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant Tumors                                                                                                            |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 47/99 (47%)  16/33 (48%) 102/149 (68%) 92/100 (92%)| 55/100 (55%) 13/29 (45%) 126/150 (84%) 98/100 (98%)|
|ADJUSTED (b)           |  63.2%        51.6%        76.0%       100.0%      |  60.1%        44.8%        85.1%       100.0%      |
|TERMINAL (d)           | 31/58 (53%)  11/26 (42%)  63/95 (66%)  48/48 (100%)| 37/73 (51%)   5/21 (24%)  93/115 (81%) 60/60 (100%)|
|FIRST INCIDENCE (DAYS) |   180          516          532          507       |   327          359          440          275       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P<0.001 **   P=0.199N     P=0.040 *    P<0.001 ** |  P<0.001 **   P=0.292N     P<0.001 **   P<0.001 ** |
|INCIDENTAL TUMOR       |  P<0.001 **   P=0.353N     P=0.054      P<0.001 ** |  P<0.001 **   P=0.179N     P<0.001 **   P<0.001 ** |
|LOGISTIC REGRESSION    |  P<0.001 **   P=0.278N     P=0.032 *    P<0.001 ** |  P<0.001 **   P=0.194N     P<0.001 **   P<0.001 ** |
|COCHRAN-ARMITAGE       |  P<0.001 **                                        |  P<0.001 **                                        |
|FISHER EXACT           |               P=0.539      P<0.001 **   P<0.001 ** |               P=0.225N     P<0.001 **   P<0.001 ** |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant and Benign Tumors                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |    #            #            #            #        |    #            #            #            #        |
|-----------            |                                                    |                                                    |
|OVERALL (a)            | 63/99 (64%)  25/33 (76%) 127/149 (85%) 94/100 (94%)| 69/100 (69%) 20/29 (69%) 148/150 (99%) 98/100 (98%)|
|ADJUSTED (b)           |  80.7%        80.6%        92.0%       100.0%      |  74.0%        69.0%        99.3%       100.0%      |
|TERMINAL (d)           | 43/58 (74%)  20/26 (77%)  84/95 (88%)  48/48 (100%)| 49/73 (67%)  12/21 (57%) 114/115 (99%) 60/60 (100%)|
|FIRST INCIDENCE (DAYS) |   180          516          526          241       |   327          359          440          275       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |  P<0.001 **   P=0.347N     P=0.046 *    P<0.001 ** |  P<0.001 **   P=0.539      P<0.001 **   P<0.001 ** |
|INCIDENTAL TUMOR       |  P<0.001 **   P=0.502      P=0.029 *    P<0.001 ** |  P<0.001 **   P=0.564N     P<0.001 **   P<0.001 ** |
|LOGISTIC REGRESSION    |  P<0.001 **   P=0.576N     P=0.016 *    P<0.001 ** |  P<0.001 **   P=0.570N     P<0.001 **   P<0.001 ** |
|COCHRAN-ARMITAGE       |  P<0.001 **                                        |  P<0.001 **                                        |
|FISHER EXACT           |               P=0.143      P<0.001 **   P<0.001 ** |               P=0.583N     P<0.001 **   P<0.001 ** |
|=================================================================================================================================|
 
         DATE: 09/10/94                     EXPERIMENT: 05076 TEST: 02                                                 PAGE  26
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN MICE(B6C3F1) -- ETHYLENETHIOUREA
 
                                                 MALE TERMINAL SACRIFICE AT 107 WEEKS
                                                 FEMALE TERMINAL SACRIFICE AT 106 WEEKS
 
 
 (a)  Number of tumor-bearing animals / number of animals examined at site.
 (b)  Kaplan-Meier estimated lifetime tumor incidence after adjustment for 
      intercurrent mortality.
 (d)  Observed incidence at terminal kill.
 (f)  Beneath the control incidence are the P-values associated with the trend 
      test.  Beneath the dosed group incidence are the P-values corresponding to 
      pairwise comparisons between the controls and that dosed group.  The life
      table analysis regards tumors in animals dying  prior to terminal kill as
      being (directly or indirectly) the cause of death.  The incidental tumor 
      test regards these lesions as non-fatal.  Logistic regression is an alternative
      method for analyzing the incidence of non-fatal tumors.  The Cochran-Armitage
      and Fisher's exact tests compare directly the overall incidence rates.  
      For all tests, a negative trend is indicated by "N".
 (e)  Value of Statistic cannot be computed. 
 (I)  Interim sacrifice
 (T)  Terminal sacrifice
  #   Tumor rates based on number of animals necropsied.
 
  *   To the right of any statistical result, indicates significance at (P<=0.05).
  **  To the right of any statistical result, indicates significance at (P<=0.01).

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