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TR 388 Mouse Pathology Tables

NTP Experiment-Test: 05076-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/29/97
Route: DOSED FEED                                                                                                 Time: 18:14:58




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  96-45-7

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All






































                                                              Page   1

NTP Experiment-Test: 05076-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 18:14:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 6| 6| 7| 4| 4| 7| 7|             
                             DAY ON TEST   | 4| 4| 4| 4| 9| 4| 0| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 8| 9| 4| 4| 1| 9| 4| 4|             
                                           | 0| 0| 0| 0| 9| 0| 5| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 7| 8| 8| 3| 1| 9| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0 PPM                                  | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    0-0                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  A  A  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                            X                                             |             
      Hematopoietic Cell Proliferation     | 2     2           2                             2           2            |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Infarct                              |                                                                         2|             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic Active         |                   2                 2                                    |             
      Necrosis                             |                                                          1               |             
      Centrilobular, Vacuolization         |                                                                          |             
          Cytoplasmic                      |                                                          3               |             
                                            __________________________________________________________________________|             
   Mesentery                               |                +                                                         |             
      Inflammation, Chronic Active         |                3                                                         |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |                                  4                                       |             
      Duct, Ectasia                        |                                  3                                       |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Perivascular, Inflammation, Chronic  |                                                                          |             
          Active, Multifocal               |             3                                                            |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Dysplasia                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bacterium, Acute, Multiple           |                                                       X                  |             
      Thrombosis                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Fatty                  |                                     2     3                              |             
      Hyperplasia                          |                                     2                                    |             
      Hypertrophy                          |                                           2           2                 2|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05076-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 18:14:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 6| 6| 7| 4| 4| 7| 7|             
                             DAY ON TEST   | 4| 4| 4| 4| 9| 4| 0| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 8| 9| 4| 4| 1| 9| 4| 4|             
                                           | 0| 0| 0| 0| 9| 0| 5| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 7| 8| 8| 3| 1| 9| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0 PPM                                  | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    0-0                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |          3                                                               |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Pars Distalis, Hyperplasia           | 2  3  3  2                 2        2  2  3  2  2                        |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Hyperplasia         |                                                                          |             
      Follicular Cell, Vacuolization       |                                                                          |             
          Cytoplasmic                      |                                                    2                     |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |                                                                          |             
      Dilatation                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                          4               |             
      Follicle, Cyst                       |    X              X  X  X     X  X  X  X  X  X  X                       X|             
      Periovarian Tissue, Cyst             |                      X                                            X  X   |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +|             
      Dilatation                           |                            3                                             |             
      Endometrium, Hyperplasia, Cystic,    |                                                                          |             
           Glandular                       | 3  3  3  2  2  3  3  2  3     3  3  3  3  2  3  3  2        2     3  2  2|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lumbar, Sinus, Lymphatic, Ectasia    |                                                                          |             
      Mandibular, Hyperplasia, Lymphoid    |                                                                          |             
      Mandibular, Infiltration Cellular,   |                                                                          |             
           Plasma Cell                     |                                        3                                 |             
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +     +        +  M              +                                   +   |             
      Hematopoietic Cell Proliferation     | 2                                                                    3   |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Thoracic                    |                +                                               +         |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                              2                           |             
      Hematopoietic Cell Proliferation     | 2                 4                                3     3               |             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  M  M  A  A  +  M  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05076-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 18:14:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4| 6| 6| 7| 4| 4| 7| 7|             
                             DAY ON TEST   | 4| 4| 4| 4| 9| 4| 0| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 8| 9| 4| 4| 1| 9| 4| 4|             
                                           | 0| 0| 0| 0| 9| 0| 5| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 7| 8| 8| 3| 1| 9| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0 PPM                                  | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    0-0                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  M  +  +  +  +  +  M  M  M  +  +  +  M  +  +  +  +  M  M  M  M  +  +  +|             
      Hyperplasia, Cystic                  |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                               2  2  2  2  2                              |             
      Parasite External                    |                               X  X  X  X  X                              |             
      Ulcer                                |                                        3                                 |             
      Subcutaneous Tissue, Fibrosis        |                            2                                             |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Hydrocephalus                        |                                                                          |             
      Perivascular, Inflammation, Chronic  |                                                                          |             
          Active                           |             3                                                            |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |             +                                                            |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Interstitium, Inflammation, Acute    |                                                       3                  |             
      Mediastinum, Hyperplasia, Lymphoid   |                                                                          |             
      Peribronchiolar, Inflammation,       |                                                                          |             
          Chronic Active                   | 2  2                 1                 1  3                 1            |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +                             +                                          |             
                                            __________________________________________________________________________|             
   Lacrimal Gland                          |                               +                                          |             
      Inflammation, Chronic Active         |                               3                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infarct                              |                                                                          |             
      Pelvis, Inflammation, Suppurative    |                                                       3                  |             
      Renal Tubule, Cyst                   |                   X                                                      |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                                                       3                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05076-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 18:14:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 6| 3|            |
                             DAY ON TEST   | 4| 4| 4| 4| 6| 4| 4| 4| 4| 4| 4| 6| 4| 4| 2| 4| 5| 5| 0| 1| 5| 6| 5| 7| 2|            |
                                           | 3| 0| 7| 7| 7| 7| 8| 8| 8| 8| 9| 5| 9| 9| 4| 9| 0| 0| 1| 4| 0| 7| 0| 0| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|      A     |
    0 PPM                                  | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|      L     |
    0-0                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  A  +  +  +  +  +  +  +  +  +  A  +  +  A  +  +  +  +  +  +  +  +  +  A|  41        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  M  +  +  +  +  +  +  +  +  +  A  +  +  A  +  +  +  +  +  +  +  +  +  +|  44        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  M  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  M  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  M  +  +  +  +  +  +  +  +  +  A  +  +  A  +  +  +  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     |                                        X                                 |      2     |
      Hematopoietic Cell Proliferation     | 2           2                                               2            |      8  2.0|
      Hyperplasia, Lymphoid                |          2                                                               |      1  2.0|
      Infarct                              |                                  2                       3               |      3  2.3|
      Inflammation, Acute                  |                            2                                             |      1  2.0|
      Inflammation, Chronic Active         |                                                                          |      2  2.0|
      Necrosis                             |                                                       1                  |      2  1.0|
      Centrilobular, Vacuolization         |                                                                          |            |
          Cytoplasmic                      |                                                       4                  |      2  3.5|
                                            __________________________________________________________________________|____________|
   Mesentery                               |          +        +  +                                +  +               |   6        |
      Inflammation, Chronic Active         |          3                                                               |      2  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acinus, Atrophy                      |                                                             4            |      2  4.0|
      Duct, Ectasia                        |                                                             3            |      2  3.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Perivascular, Inflammation, Chronic  |                                                                          |            |
          Active, Multifocal               |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Dysplasia                            |                                                                   2      |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Bacterium, Acute, Multiple           |                                                                          |      1     |
      Thrombosis                           |                                  X                                       |      1     |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   5                                                               
NTP Experiment-Test: 05076-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 18:14:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 6| 3|            |
                             DAY ON TEST   | 4| 4| 4| 4| 6| 4| 4| 4| 4| 4| 4| 6| 4| 4| 2| 4| 5| 5| 0| 1| 5| 6| 5| 7| 2|            |
                                           | 3| 0| 7| 7| 7| 7| 8| 8| 8| 8| 9| 5| 9| 9| 4| 9| 0| 0| 1| 4| 0| 7| 0| 0| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|      A     |
    0 PPM                                  | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|      L     |
    0-0                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Degeneration, Fatty                  |                            3                    3                        |      4  2.8|
      Hyperplasia                          |                                                                          |      1  2.0|
      Hypertrophy                          |                                                                          |      3  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia, Focal                   |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  M  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Pars Distalis, Hyperplasia           |          2              2           3        2     3  2  1  1     2      |     19  2.2|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Follicular Cell, Hyperplasia         |                   2        3                                             |      2  2.5|
      Follicular Cell, Vacuolization       |                                                                          |            |
          Cytoplasmic                      |                   2        2                                             |      3  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |                                  +                                       |   1        |
      Dilatation                           |                                  3                                       |      1  3.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Suppurative            |                                                                          |      1  4.0|
      Follicle, Cyst                       | X           X           X                       X                        |     16     |
      Periovarian Tissue, Cyst             |                                                                          |      3     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Dilatation                           |                                                       3                  |      2  3.0|
      Endometrium, Hyperplasia, Cystic,    |                                                                          |            |
           Glandular                       | 2        3  2  3  2  3  3     2  2  3  2     3  3           3  3  2  3  2|     39  2.6|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Lumbar, Sinus, Lymphatic, Ectasia    |                                                    4                     |      1  4.0|
      Mandibular, Hyperplasia, Lymphoid    | 2                                            2                           |      2  2.0|
      Mandibular, Infiltration Cellular,   |                                                                          |            |
           Plasma Cell                     |                                                                          |      1  3.0|
      Mediastinal, Hyperplasia, Lymphoid   |          2                                                               |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   6                                                               
NTP Experiment-Test: 05076-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 18:14:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 6| 3|            |
                             DAY ON TEST   | 4| 4| 4| 4| 6| 4| 4| 4| 4| 4| 4| 6| 4| 4| 2| 4| 5| 5| 0| 1| 5| 6| 5| 7| 2|            |
                                           | 3| 0| 7| 7| 7| 7| 8| 8| 8| 8| 9| 5| 9| 9| 4| 9| 0| 0| 1| 4| 0| 7| 0| 0| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|      A     |
    0 PPM                                  | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|      L     |
    0-0                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |          +  +     +           +  +     +  +              +              +|  14        |
      Hematopoietic Cell Proliferation     |                                                                          |      2  2.5|
      Hemorrhage                           |             2                                                            |      1  2.0|
      Hyperplasia, Lymphoid                |          2                                                               |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Thoracic                    |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fibrosis                             |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     |             3                                                            |      5  3.0|
      Hyperplasia, Lymphoid                | 2        2                                   2                           |      3  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  M  +  +  +  +  +  M  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  M  +|  39        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  M  +  M  M  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|  35        |
      Hyperplasia, Cystic                  |                                                                4         |      1  4.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acanthosis                           |                                                                          |      5  2.0|
      Parasite External                    |                                                          X               |      6     |
      Ulcer                                |                                                                          |      1  3.0|
      Subcutaneous Tissue, Fibrosis        |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression                          |       X                                                        X         |      2     |
      Hemorrhage                           |                                                       2  2               |      2  2.0|
      Hydrocephalus                        |       2                                                              3   |      2  2.5|
      Perivascular, Inflammation, Chronic  |                                                                          |            |
          Active                           |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Alveolar Epithelium, Hyperplasia     |                            2                                             |      1  2.0|
      Interstitium, Inflammation, Acute    |                                                                          |      1  3.0|
      Mediastinum, Hyperplasia, Lymphoid   | 2                                                                        |      1  2.0|
      Peribronchiolar, Inflammation,       |                                                                          |            |
          Chronic Active                   |                2        2  1                 1  2     3              2   |     13  1.8|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   7                                                               
NTP Experiment-Test: 05076-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 18:14:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 6| 3|            |
                             DAY ON TEST   | 4| 4| 4| 4| 6| 4| 4| 4| 4| 4| 4| 6| 4| 4| 2| 4| 5| 5| 0| 1| 5| 6| 5| 7| 2|            |
                                           | 3| 0| 7| 7| 7| 7| 8| 8| 8| 8| 9| 5| 9| 9| 4| 9| 0| 0| 1| 4| 0| 7| 0| 0| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|      A     |
    0 PPM                                  | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|      L     |
    0-0                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +     +     +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                       +                  |   3        |
                                            __________________________________________________________________________|____________|
   Lacrimal Gland                          |                                                                          |   1        |
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infarct                              | 2                                                                        |      1  2.0|
      Pelvis, Inflammation, Suppurative    |                                                                          |      1  3.0|
      Renal Tubule, Cyst                   |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Inflammation, Acute                  |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   8                                                               
NTP Experiment-Test: 05076-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 18:14:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 7| 7| 7| 7| 7| 5| 5| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 6| 7| 7|             
                             DAY ON TEST   | 4| 4| 4| 9| 4| 4| 4| 2| 4| 2| 5| 4| 4| 4| 4| 4| 4| 4| 1| 4| 1| 4| 9| 4| 4|             
                                           | 0| 0| 0| 1| 0| 1| 1| 5| 1| 3| 5| 1| 1| 2| 2| 0| 2| 2| 2| 2| 1| 3| 8| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    0 PPM                                  | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    10-0                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |          +           +     +  +              +        +     +     +      |             
                                            __________________________________________________________________________|             
   Gallbladder                             |          A           A     M  +              A        +     +     +      |             
                                            __________________________________________________________________________|             
   Intestine Large                         |          A     +     +     +  +              +        +     +     +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |          A           A     +  +              +        +     +     +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |          A           +     +  +              +        +     +     +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |          A           +     +  +              +        +     +     +      |             
                                            __________________________________________________________________________|             
   Intestine Small                         |          A           A     +  +              +     +  +     +     +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |          A           A     +  +              +        +     +     +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |          A           A     +  +              +        +     +     +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |          A           A     +  +              +     +  +     +     +      |             
      Inflammation, Chronic Active         |                                                             3            |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                                                         X|             
      Clear Cell Focus                     |                                                                      X   |             
      Hematopoietic Cell Proliferation     |                                                             2            |             
      Infarct                              |                                              4                           |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |          A           A     +  +              +        +     +     +      |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |          A           +     +  +              +        +     +     +      |             
                                            __________________________________________________________________________|             
   Stomach                                 |       +  A           A     +  +     +        +        +     +     +      |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |       +  A           A     +  +     +        +        +     +     +      |             
      Cyst Epithelial Inclusion            |                                     X                                    |             
      Hyperkeratosis, Focal                |                                                                          |             
      Inflammation, Chronic Active         |                                     3                                    |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |          A           A     +  +              +        +     +     +      |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |          +           +     +  +              +        +     +     +      |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |          +           +     +  +              +        +     +     +      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |          +           +     +  +              +        +     +     +      |             
      Hematopoietic Cell Proliferation     |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |          +           +     +  +              +        +     +     +      |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |          A     +     A     +  +              +        +     +     +      |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |          M           +     +  +              +        +     +     +      |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                                                                          |             
      Pars Distalis, Hyperplasia           | 3     3     2           2        2     1  1        2                 2  2|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Hyperplasia         | 1                 2                 2                          2         |             
      Follicular Cell, Vacuolization       |                                                                          |             
          Cytoplasmic                      |                      2                                                   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   9                                                               
NTP Experiment-Test: 05076-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 18:14:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 7| 7| 7| 7| 7| 5| 5| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 6| 7| 7|             
                             DAY ON TEST   | 4| 4| 4| 9| 4| 4| 4| 2| 4| 2| 5| 4| 4| 4| 4| 4| 4| 4| 1| 4| 1| 4| 9| 4| 4|             
                                           | 0| 0| 0| 1| 0| 1| 1| 5| 1| 3| 5| 1| 1| 2| 2| 0| 2| 2| 2| 2| 1| 3| 8| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    0 PPM                                  | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    10-0                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   |    +  +  A           +     +  +  +           +  +     +  +  +  +  +      |             
      Follicle, Cyst                       |       X              X        X                          X  X            |             
      Periovarian Tissue, Cyst             |    X                             X              X              X         |             
                                            __________________________________________________________________________|             
   Uterus                                  |       +  A     +  +  +  +  +  +  +     +     +  +     +  +  +  +  +      |             
      Endometrium, Hyperplasia, Cystic,    |                                                                          |             
           Glandular                       |       3        3  3  3  2  2     3     3        3        3  2  3  3      |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |          +           +     +  +              +        +     +     +      |             
      Femoral, Necrosis, Acute             |                                                             3            |             
                                            __________________________________________________________________________|             
   Lymph Node                              |          A           +  +  +  +           +  +     +  +     +     +      |             
      Mandibular, Angiectasis              |                                                                          |             
      Mandibular, Hyperplasia, Lymphoid    |                         3                                                |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                            +              +           +           +      |             
      Hematopoietic Cell Proliferation     |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  |       +  +  +        +     +  +  +        +  +     +  +     +     +      |             
      Hematopoietic Cell Proliferation     |          2                                   3                           |             
      Hyperplasia, Lymphoid                |             2                                                            |             
                                            __________________________________________________________________________|             
   Thymus                                  |          A           +     M  +              M        +     I     M      |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |          M           +     +  +              +        +     +     +      |             
                                            __________________________________________________________________________|             
   Skin                                    |          +           +     +  +              +        +     +     +      |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |          +           +     +  +              +        +     +     +      |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |          +           +     +  +              +        +     +     +      |             
      Compression                          |                                                       X                  |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Artery, Embolus                      |                                                             2            |             
      Peribronchiolar, Inflammation,       |                                                                          |             
          Chronic Active                   |                                  2  2  2              2  1               |             
                                            __________________________________________________________________________|             
   Nose                                    |          A           +     +  +              +        +     +     +      |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Acute                           |                                              2                           |             
                                            __________________________________________________________________________|             
   Trachea                                 |          A           +     +  +              +        +     +     +      |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                              +                           |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  10                                                               
NTP Experiment-Test: 05076-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 18:14:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 7| 7| 7| 7| 7| 5| 5| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 6| 7| 7|             
                             DAY ON TEST   | 4| 4| 4| 9| 4| 4| 4| 2| 4| 2| 5| 4| 4| 4| 4| 4| 4| 4| 1| 4| 1| 4| 9| 4| 4|             
                                           | 0| 0| 0| 1| 0| 1| 1| 5| 1| 3| 5| 1| 1| 2| 2| 0| 2| 2| 2| 2| 1| 3| 8| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    0 PPM                                  | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    10-0                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Atrophy                              |                                                                          |             
      Lens, Cataract                       |                                              4                           |             
      Retina, Degeneration                 |                                              4                           |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                         +                                         +      |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |          A           +     +  +              +        +     +     +      |             
      Glomerulus, Dilatation               |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |          A           +     +  +              +        +     +     +      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  11                                                               
NTP Experiment-Test: 05076-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 18:14:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 6| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 8| 4| 3| 0| 5| 5| 4| 5| 5|            |
                                           | 3| 3| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 7| 2| 7| 9| 0| 0| 6| 0| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|      A     |
    0 PPM                                  | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|      L     |
    10-0                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |                                                 +  +  +  +        +      |  13        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |                               +                 A  +  +  A        A      |   7        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |                                                 +  +  +  +        +      |  13        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |                                                 +  M  +  +        +      |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |                                                 +  +  +  +        +      |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |                                                 +  M  +  +        +      |  11        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |                                                 +  +  +  +        +      |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |                                                 +  +  +  +        +      |  11        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                                                 +  M  +  +        +      |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                                                 +  +  +  +        +      |  12        |
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Basophilic Focus                     |                                                                          |      1     |
      Clear Cell Focus                     |                                                                      X   |      2     |
      Hematopoietic Cell Proliferation     |                                                             3            |      2  2.5|
      Infarct                              |                                                          3               |      2  3.5|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                       +           +      |   2        |
                                            __________________________________________________________________________|____________|
   Pancreas                                |                                                 +  +  +  +        +      |  11        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |    +                                            +  +  +  +        +      |  13        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |                                     +     +     +  +  +  +        +      |  15        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |                                     +     +     +  +  +  +        +      |  15        |
      Cyst Epithelial Inclusion            |                                           X                              |      2     |
      Hyperkeratosis, Focal                |                                     2                                    |      1  2.0|
      Inflammation, Chronic Active         |                                           2                              |      2  2.5|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |                                                 +  +  +  +        +      |  11        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |                                                 +  +  +  +        +      |  13        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |                                                 +  +  +  +        +      |  13        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |                                                 +  +  +  +        +      |  13        |
      Hematopoietic Cell Proliferation     |                                                          2               |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |                                                 +  +  +  +        +      |  13        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |                                        +        +  +  +  +        +      |  13        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |                                                 +  +  +  +        +      |  12        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|  48        |
      Pars Distalis, Angiectasis           |                                           2                              |      1  2.0|
      Pars Distalis, Hyperplasia           | 1  1        2     2           2  2     2     2                       2   |     19  1.9|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  12                                                               
NTP Experiment-Test: 05076-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 18:14:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 6| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 8| 4| 3| 0| 5| 5| 4| 5| 5|            |
                                           | 3| 3| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 7| 2| 7| 9| 0| 0| 6| 0| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|      A     |
    0 PPM                                  | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|      L     |
    10-0                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Follicular Cell, Hyperplasia         | 1                 1                    2  2                              |      8  1.6|
      Follicular Cell, Vacuolization       |                                                                          |            |
          Cytoplasmic                      |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   |    +        +  +     +  +                       +  +  +  +     +  +  +  +|  26        |
      Follicle, Cyst                       |                      X                             X                 X   |      8     |
      Periovarian Tissue, Cyst             |    X           X     X                                         X        X|      9     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +     +  +  +        +     +     +  +  +  +  +        +     +|  33        |
      Endometrium, Hyperplasia, Cystic,    |                                                                          |            |
           Glandular                       | 3  3  3  3  3     3  3  3        3     3     3  2  3  3                 3|     28  2.9|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |                                                 +  +  +  +        +      |  13        |
      Femoral, Necrosis, Acute             |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                     +           +  +  +  +  +     +  +   |  18        |
      Mandibular, Angiectasis              |                                                             3            |      1  3.0|
      Mandibular, Hyperplasia, Lymphoid    |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                                     +           +  +  +           +  +   |  10        |
      Hematopoietic Cell Proliferation     |                                     2                                    |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  |    +     +  +                                   +  +  +  +  +     +  +   |  23        |
      Hematopoietic Cell Proliferation     |                                                       3                  |      3  2.7|
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  |                                                 +  +  +  M        +      |   7        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |                                                 +  +  +  +  +     +      |  13        |
                                            __________________________________________________________________________|____________|
   Skin                                    |                                                 +  +  +  +        +      |  13        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |                                                 +  +  +  +        +      |  13        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |                                                 +  +  +  +        +      |  13        |
      Compression                          |                                                                          |      1     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  13                                                               
NTP Experiment-Test: 05076-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 18:14:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 6| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 8| 4| 3| 0| 5| 5| 4| 5| 5|            |
                                           | 3| 3| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 7| 2| 7| 9| 0| 0| 6| 0| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|      A     |
    0 PPM                                  | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|      L     |
    10-0                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Alveolar Epithelium, Hyperplasia     |             2                                                            |      1  2.0|
      Artery, Embolus                      |                                                                          |      1  2.0|
      Peribronchiolar, Inflammation,       |                                                                          |            |
          Chronic Active                   |                                                                          |      5  1.8|
                                            __________________________________________________________________________|____________|
   Nose                                    |                                                 +  +  +  +        +      |  12        |
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Acute                           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 |                                                 +  +  +  +        +      |  12        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                               +                                          |   2        |
      Atrophy                              |                               4                                          |      1  4.0|
      Lens, Cataract                       |                                                                          |      1  4.0|
      Retina, Degeneration                 |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                               +                                          |   3        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |                                                 +  +  +  +        +      |  12        |
      Glomerulus, Dilatation               |                                                    2                     |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |                                                 +  +  +  +        +      |  12        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  14                                                               
NTP Experiment-Test: 05076-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 18:14:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 7| 3| 7| 7| 7| 5| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 6| 0| 5| 4| 4| 4| 6| 4| 4| 4| 5| 4| 4| 5| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                                           | 9| 8| 5| 9| 0| 0| 1| 2| 1| 2| 2| 2| 3| 3| 5| 3| 7| 7| 7| 8| 8| 8| 9| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    100 PPM                                | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
      1-1                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +           +           +        +                              |             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +           +           +        +                              |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +           +           +        +                              |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +           +           +        +                              |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +           +           +        +                              |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +           +           +        +                              |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +           +           +        +                 +     +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +           +           +        +                              |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +           +           +        +                              |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +           +           +        +                 +     +      |             
      Peyer's Patch, Hyperplasia, Lymphoid |                                                             2            |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Eosinophilic Focus                   |                                                                X         |             
      Hematopoietic Cell Proliferation     |                         2                                                |             
      Infarct                              |             3                                                            |             
      Centrilobular, Cytomegaly            |                                     2           2                        |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +           +           +        +                              |             
      Acinus, Atrophy                      |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +           +           +        +                              |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +           +           +        +                       +     +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +           +           +        +                       +     +|             
      Cyst Epithelial Inclusion            |                                                                   X      |             
      Hyperplasia, Squamous                |                                                                         3|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +           +           +        +                              |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +           +           +        +                              |             
      Mineralization                       |                                  2                                       |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +           +           +        +                              |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +           +           +        +                              |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +           +           +        +                              |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +           +           +        +                              |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +           +           +        M                              |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Hyperplasia           |                   3           2  1        1           2  2           2   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Vacuolization       |                                                                          |             
          Cytoplasmic                      | 1  2  1     1  1  1  2     1     1     3  2     1  1  1  2     2  2      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  15                                                               
NTP Experiment-Test: 05076-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 18:14:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 7| 3| 7| 7| 7| 5| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 6| 0| 5| 4| 4| 4| 6| 4| 4| 4| 5| 4| 4| 5| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                                           | 9| 8| 5| 9| 0| 0| 1| 2| 1| 2| 2| 2| 3| 3| 5| 3| 7| 7| 7| 8| 8| 8| 9| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    100 PPM                                | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
      1-1                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +     +  +  +     +  +     +  +  +  +  +  +           +  +  +|             
      Angiectasis                          |                                                    3                 2   |             
      Thrombosis                           |             X                                                            |             
      Follicle, Cyst                       |                   X     X     X        X     X        X           X      |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +        +  +     +     +  +     +              +               |             
      Endometrium, Hyperplasia, Cystic,    |                                                                          |             
           Glandular                       | 2  3              3        2        3                    2               |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +           +           +        +                              |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +        +        +  +        +              +  +     +     +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |    +        +                 +  +        +              +  +            |             
      Hematopoietic Cell Proliferation     |             2                                               2            |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +           +     +  +  +        +              +        +  +   |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  M  +  M           +           M        +                              |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +           +        +  +        +                              |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +           +           +        +                              |             
      Acanthosis                           | 2  2                 2                    2                              |             
      Parasite External                    | X  X  X  X           X                    X                              |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +        +           +        +                              |             
      Tarsal, Hyperostosis                 |             X                             X                              |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +           +           +        +                              |             
      Compression                          |          X                                                               |             
      Hemorrhage                           |                                           3                              |             
                                            __________________________________________________________________________|             
   Spinal Cord                             | +                                                                        |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Peribronchiolar, Inflammation,       |                                                                          |             
          Chronic Active                   |                      2              1                                    |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +           +           +        +                              |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +           +           +        +                              |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                      +                                                   |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  16                                                               
NTP Experiment-Test: 05076-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 18:14:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 7| 3| 7| 7| 7| 5| 7| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 6| 0| 5| 4| 4| 4| 6| 4| 4| 4| 5| 4| 4| 5| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                                           | 9| 8| 5| 9| 0| 0| 1| 2| 1| 2| 2| 2| 3| 3| 5| 3| 7| 7| 7| 8| 8| 8| 9| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    100 PPM                                | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
      1-1                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +           +           +        +                              |             
      Hemorrhage                           |                                  3                                       |             
      Nephropathy, Chronic                 | 1                                                                        |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +           +           +        +                              |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  17                                                               
NTP Experiment-Test: 05076-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 18:14:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7|                                                              |            |
                             DAY ON TEST   | 5| 5| 1| 5|                                                              |            |
                                           | 0| 0| 2| 0|                                                              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0|                                                              |      O     |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1|                                                              |      T     |
                               ANIMAL ID   | 0| 0| 0| 0|                                                              |      A     |
    100 PPM                                | 3| 3| 3| 3|                                                              |      L     |
      1-1                                  | 1| 2| 3| 4|                                                              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |       +                                                                  |   8        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |       +                                                                  |   8        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |       +                                                                  |   8        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |       +                                                                  |   8        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |       +                                                                  |   8        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |       +                                                                  |   8        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |       +                                                                  |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |       +                                                                  |   8        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |       +                                                                  |   8        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |       +                                                                  |  10        |
      Peyer's Patch, Hyperplasia, Lymphoid |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +                                                               |  28        |
      Eosinophilic Focus                   |          X                                                               |      2     |
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
      Infarct                              |       2                                                                  |      2  2.5|
      Centrilobular, Cytomegaly            |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                |       +                                                                  |   8        |
      Acinus, Atrophy                      |       3                                                                  |      1  3.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |       +                                                                  |   8        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |       +                                                                  |  10        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |       +                                                                  |  10        |
      Cyst Epithelial Inclusion            |                                                                          |      1     |
      Hyperplasia, Squamous                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |       +                                                                  |   8        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |       +                                                                  |   8        |
      Mineralization                       |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |       +                                                                  |   8        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |       +                                                                  |   8        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |       +                                                                  |   8        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |       +                                                                  |   8        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |       +                                                                  |   7        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +                                                               |  28        |
      Pars Distalis, Hyperplasia           |    3                                                                     |      8  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +                                                               |  29        |
      Follicular Cell, Vacuolization       |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  18                                                               
NTP Experiment-Test: 05076-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 18:14:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7|                                                              |            |
                             DAY ON TEST   | 5| 5| 1| 5|                                                              |            |
                                           | 0| 0| 2| 0|                                                              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0|                                                              |      O     |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1|                                                              |      T     |
                               ANIMAL ID   | 0| 0| 0| 0|                                                              |      A     |
    100 PPM                                | 3| 3| 3| 3|                                                              |      L     |
      1-1                                  | 1| 2| 3| 4|                                                              |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
          Cytoplasmic                      | 2     2                                                                  |     19  1.5|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   |       +                                                                  |  20        |
      Angiectasis                          |                                                                          |      2  2.5|
      Thrombosis                           |                                                                          |      1     |
      Follicle, Cyst                       |       X                                                                  |      8     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +     +                                                                  |  13        |
      Endometrium, Hyperplasia, Cystic,    |                                                                          |            |
           Glandular                       | 3                                                                        |      7  2.6|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |       +                                                                  |   8        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +     +                                                                  |  15        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |       +                                                                  |   8        |
      Hematopoietic Cell Proliferation     |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  |       +                                                                  |  13        |
                                            __________________________________________________________________________|____________|
   Thymus                                  |       M                                                                  |   4        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |       M                                                                  |   8        |
                                            __________________________________________________________________________|____________|
   Skin                                    |       +                                                                  |   8        |
      Acanthosis                           |                                                                          |      4  2.0|
      Parasite External                    |                                                                          |      6     |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |       +                                                                  |   9        |
      Tarsal, Hyperostosis                 |                                                                          |      2     |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |       +                                                                  |   8        |
      Compression                          |                                                                          |      1     |
      Hemorrhage                           |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  19                                                               
NTP Experiment-Test: 05076-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 18:14:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7|                                                              |            |
                             DAY ON TEST   | 5| 5| 1| 5|                                                              |            |
                                           | 0| 0| 2| 0|                                                              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0|                                                              |      O     |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1|                                                              |      T     |
                               ANIMAL ID   | 0| 0| 0| 0|                                                              |      A     |
    100 PPM                                | 3| 3| 3| 3|                                                              |      L     |
      1-1                                  | 1| 2| 3| 4|                                                              |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +                                                               |  29        |
      Peribronchiolar, Inflammation,       |                                                                          |            |
          Chronic Active                   |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Nose                                    |       +                                                                  |   8        |
                                            __________________________________________________________________________|____________|
   Trachea                                 |       +                                                                  |   8        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |       +                                                                  |   8        |
      Hemorrhage                           |                                                                          |      1  3.0|
      Nephropathy, Chronic                 |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |       +                                                                  |   8        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  20                                                               
NTP Experiment-Test: 05076-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 18:14:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 4| 6| 4| 4| 6| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0| 4| 6| 4| 4| 4| 4| 4| 4| 4| 4|             
                                           | 0| 8| 0| 0| 9| 0| 0| 0| 1| 1| 1| 1| 1| 1| 3| 2| 7| 2| 2| 2| 2| 2| 3| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    333 PPM                                | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
      0-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +        +                             +     +                        |             
                                            __________________________________________________________________________|             
   Gallbladder                             |    +        +                             +     +                        |             
                                            __________________________________________________________________________|             
   Intestine Large                         |    +        +                          +  +     +                        |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    +        +                             +     +                        |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +        +                          +  +     +                        |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +        +                             +     +                        |             
                                            __________________________________________________________________________|             
   Intestine Small                         |    +        +                          +  +     +                        |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +        +                             +     +                        |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    +        +                             +     +                        |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +        +                          +  +     +                        |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                X                                   X     X               |             
      Clear Cell Focus                     | X                                                                        |             
      Eosinophilic Focus                   | X        X  X                    X                    X                  |             
      Hematopoietic Cell Proliferation     |                                                 2                        |             
      Infarct                              |                                                                      3   |             
      Necrosis                             |          1                                                               |             
      Vacuolization Cytoplasmic            |                                                 2                        |             
      Bile Duct, Mineralization, Multifocal|                                                 2                        |             
      Centrilobular, Cytomegaly            |          2  2     2     2           2              1        2  2         |             
      Centrilobular, Necrosis              |                                           2                              |             
      Centrilobular, Vacuolization         |                                                                          |             
          Cytoplasmic                      |                                           3                              |             
      Oval Cell, Hyperplasia               |             3                                                            |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                 +                        |             
      Inflammation, Chronic Active         |                                                 4                        |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +        +                             +     +                        |             
      Acinus, Atrophy                      |                                                 3                        |             
      Acinus, Inflammation, Chronic Active |                                                 3                        |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +        +                             +     +                        |             
                                            __________________________________________________________________________|             
   Stomach                                 |    +        +  +        +                 +     +                        |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +        +  +        +                 +     +                        |             
      Acanthosis                           |                         4                                                |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +        +                             +     +                        |             
      Subserosa, Inflammation, Chronic     |             2                                                            |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |    +        +                             +     +                        |             
      Mineralization                       |                                                 2                        |             
      Thrombosis                           |             X                                                            |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |    +        +                             +     +                        |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |    +        +                             +     +                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  21                                                               
NTP Experiment-Test: 05076-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 18:14:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 4| 6| 4| 4| 6| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0| 4| 6| 4| 4| 4| 4| 4| 4| 4| 4|             
                                           | 0| 8| 0| 0| 9| 0| 0| 0| 1| 1| 1| 1| 1| 1| 3| 2| 7| 2| 2| 2| 2| 2| 3| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    333 PPM                                | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
      0-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |    +        +                             +     +                        |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +        +                             +     +                        |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    +        +                             +     +                        |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Hyperplasia           |    3     2        2     1  2                 3     2  2     3  2  2  2   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Hyperplasia         |                                        2  3  2              1            |             
      Follicular Cell, Vacuolization       |                                                                          |             
          Cytoplasmic                      | 2  2  2  2  3  3  3  2  3  3  3  2  3  4  3  4  2  3  3  2  1  3  3  3  3|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   |    +     +  +  +                          +     +     +  +               |             
      Follicle, Cyst                       |    X     X                                            X  X               |             
      Periovarian Tissue, Cyst             |                X                                                         |             
                                            __________________________________________________________________________|             
   Uterus                                  |    +  +     +  +     +     +              +  +  +                       +|             
      Endometrium, Hyperplasia, Cystic,    |                                                                          |             
           Glandular                       |       3        3     3     3                 2  3                       3|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +        +                             +     +                        |             
      Angiectasis                          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +        +  +        +           +  +  +     +     +        +        +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |    +           +                       +              +        +        +|             
      Hematopoietic Cell Proliferation     |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  |    +     +  +  +  +  +  +              +  +  +  +  +  +  +     +  +      |             
      Hematopoietic Cell Proliferation     |                                                                3  3      |             
      Hyperplasia, Lymphoid                |                   2  2                                                   |             
                                            __________________________________________________________________________|             
   Thymus                                  |    +     +  +                             +     M                        |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    +        +                             +     +                        |             
                                            __________________________________________________________________________|             
   Skin                                    |    +        +                             +     +                        |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +        +                             +     +                        |             
      Tarsal, Hyperostosis                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +        +                             +     +                        |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  22                                                               
NTP Experiment-Test: 05076-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 18:14:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 4| 6| 4| 4| 6| 4| 4| 4| 4| 4| 4| 4| 4| 4| 0| 4| 6| 4| 4| 4| 4| 4| 4| 4| 4|             
                                           | 0| 8| 0| 0| 9| 0| 0| 0| 1| 1| 1| 1| 1| 1| 3| 2| 7| 2| 2| 2| 2| 2| 3| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    333 PPM                                | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
      0-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Peribronchiolar, Inflammation,       |                                                                          |             
          Chronic Active                   |                                                                   2      |             
                                            __________________________________________________________________________|             
   Nose                                    |    +        +                             +     +                        |             
                                            __________________________________________________________________________|             
   Trachea                                 |    +        +                             +     +                        |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Atrophy                              |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +                                                                        |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |    +        +           +                 +     +                        |             
      Nephropathy, Chronic                 |                                                 1                        |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +        +                             +     +                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  23                                                               
NTP Experiment-Test: 05076-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 18:14:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 7| 6| 4| 4| 2| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 4| 5|            |
                                           | 4| 7| 3| 3| 9| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 3| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    333 PPM                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      L     |
      0-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +        +                                                        +   |   8        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +        +                                                        A   |   7        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +        +                                                        +   |   9        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +        +                                                        A   |   7        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +        +                                                        +   |   9        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +        +                                                        A   |   7        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +        +                                                        +   |   9        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +        +                                                        +   |   8        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +        +                                                        A   |   7        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +        +                                                        A   |   8        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     |                                                                          |      3     |
      Clear Cell Focus                     |                                                                          |      1     |
      Eosinophilic Focus                   |       X  X        X     X              X                    X            |     11     |
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
      Infarct                              |    2                 3                       2  3                        |      5  2.6|
      Necrosis                             |                                                                          |      1  1.0|
      Vacuolization Cytoplasmic            |                                                                          |      1  2.0|
      Bile Duct, Mineralization, Multifocal|                                                                          |      1  2.0|
      Centrilobular, Cytomegaly            |       2           2                       2                              |     11  1.9|
      Centrilobular, Necrosis              |                                                                          |      1  2.0|
      Centrilobular, Vacuolization         |                                                                          |            |
          Cytoplasmic                      |                                                                          |      1  3.0|
      Oval Cell, Hyperplasia               |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   1        |
      Inflammation, Chronic Active         |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +        +                                                        A   |   7        |
      Acinus, Atrophy                      |                                                                          |      1  3.0|
      Acinus, Inflammation, Chronic Active |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +        +                                                        +   |   8        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +        +                                               +        +   |  11        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +        +                                               +        +   |  11        |
      Acanthosis                           |                                                             2            |      2  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +        +                                                        +   |   8        |
      Subserosa, Inflammation, Chronic     |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +        +                                                        +   |   8        |
      Mineralization                       |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  24                                                               
NTP Experiment-Test: 05076-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 18:14:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 7| 6| 4| 4| 2| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 4| 5|            |
                                           | 4| 7| 3| 3| 9| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 3| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    333 PPM                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      L     |
      0-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Thrombosis                           |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +        +                                                        +   |   8        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +        +                                                        +   |   8        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +        +                                                        +   |   8        |
      Hyperplasia                          |    2                                                                     |      1  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +        +                                                        A   |   7        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +        +                                                        +   |   8        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Pars Distalis, Hyperplasia           |    2        2  2              3        2     2        2  1  3           2|     22  2.1|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Follicular Cell, Hyperplasia         |       2  3           2        2           2           2     2  2  2      |     13  2.1|
      Follicular Cell, Vacuolization       |                                                                          |            |
          Cytoplasmic                      | 2  3  3  3  1  3  3  3  1  3  3  3  3  3  4  3     3  2  3  4  4  4  2  3|     49  2.8|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +        +                 +        +           +                 +   |  15        |
      Follicle, Cyst                       |                                        X           X                     |      6     |
      Periovarian Tissue, Cyst             |                               X                                          |      2     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +     +  +              +     +           +        +              +   |  19        |
      Endometrium, Hyperplasia, Cystic,    |                                                                          |            |
           Glandular                       | 2        3                 3     3           3        2                  |     13  2.8|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +        +                                                        +   |   8        |
      Angiectasis                          |    3                                                                     |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +     +              +              +        +                 +   |  19        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +                    +                       +                 +   |  12        |
      Hematopoietic Cell Proliferation     |       2                                            2                     |      2  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +     +  +        +     +              +  +     +              +  +  +|  28        |
      Hematopoietic Cell Proliferation     |    3     3           3                             2                     |      6  2.8|
      Hyperplasia, Lymphoid                |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  M        M                                                        +   |   6        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  25                                                               
NTP Experiment-Test: 05076-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 18:14:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 7| 6| 4| 4| 2| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 4| 5|            |
                                           | 4| 7| 3| 3| 9| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 3| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      A     |
    333 PPM                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      L     |
      0-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +     +  +                                                            |   8        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +        +                                                        +   |   8        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +        +                                +                       +   |   9        |
      Tarsal, Hyperostosis                 |                                              X                           |      1     |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +        +                                                        +   |   8        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Peribronchiolar, Inflammation,       |                                                                          |            |
          Chronic Active                   |                3        3  2        2     3                             2|      7  2.4|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +        +                                                        +   |   8        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +        +                                                        +   |   8        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                +                                               +         |   2        |
      Atrophy                              |                4                                               4         |      2  4.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                +                 +                             +         |   4        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +        +              +                             +           +   |  11        |
      Nephropathy, Chronic                 |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +        +                                                        +   |   9        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  26                                                               
NTP Experiment-Test: 05076-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 18:14:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 6| 7| 7| 7| 7| 6| 6|             
                             DAY ON TEST   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 6| 4| 8| 4| 0| 4| 4| 4| 4| 9| 8|             
                                           | 0| 8| 7| 8| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 0| 2| 8| 2| 5| 2| 2| 3| 3| 8| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    333 PPM                                | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
      3-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +  +  +                                +     +     +              +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             |    +  +  +                                +     +     +              +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         |    +  +  +                                +     +     +              +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    +  +  +                                +     +     +              +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +  +  +                                +     +     +              +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +  +  +                                M     +     +              +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         |    +  +  +                                +     +     +  +           +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +  +  +                                +     +     +              +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    +  +  +                                +     +     +              +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +  +  +                                +     +     +  +           +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                                                          |             
      Eosinophilic Focus                   |             X                                                            |             
      Fatty Change, Focal                  |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                 2  2  4  3               |             
      Infarct                              |             3                             2                              |             
      Inflammation, Chronic Active         |             3                                                            |             
      Centrilobular, Cytomegaly            |             2  2                    1                    2  1            |             
      Centrilobular, Necrosis, Acute       |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                 +                        |             
      Inflammation, Chronic Active         |                                                 4                        |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +  +  +                          +     +     +     +              +  +|             
      Acinus, Atrophy                      |                                     3                                    |             
      Duct, Ectasia                        |                                     3                                    |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +  +  +                                +     +     +              +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 |    +  +  +  +                             +     +     +              +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +  +  +  +                             +     +     +              +  +|             
      Diverticulum                         |             2                                                            |             
      Hyperplasia, Squamous                |                                           2                              |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +  +  +                                +     +     +              +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |    +  +  +                                +     +     +              +  +|             
      Bacterium, Acute, Multiple           |                                                                          |             
      Degeneration, Chronic                |                                           4                              |             
      Inflammation, Acute                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |    +  +  +                                +     +     +              +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |    +  +  +                                +     +     +              +  +|             
      Hypertrophy                          |          2                                                               |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |    +  +  +                                +     +     +              +  +|             
      Hyperplasia                          |                                           2                              |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  27                                                               
NTP Experiment-Test: 05076-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 18:14:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 6| 7| 7| 7| 7| 6| 6|             
                             DAY ON TEST   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 6| 4| 8| 4| 0| 4| 4| 4| 4| 9| 8|             
                                           | 0| 8| 7| 8| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 0| 2| 8| 2| 5| 2| 2| 3| 3| 8| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    333 PPM                                | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
      3-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +  +  +                                +     +     +              +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    M  +  +                                +     +     +              +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +|             
      Pars Distalis, Hyperplasia           |    2     2              3  2                    2        3  2  2  4     2|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Hyperplasia         |             2  2        3     2              2     2                    2|             
      Follicular Cell, Vacuolization       |                                                                          |             
          Cytoplasmic                      | 3  3  2  2  4  3  2  3  3  2  3  3  3  3  2  4  2  3  3  3  3  3  3  2  3|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |                                                                          |             
      Dilatation                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   |    +  +  +     +              +     +     +     M  +  +              +  +|             
      Follicle, Cyst                       |                X              X     X              X  X                  |             
      Periovarian Tissue, Cyst             |                                           X                              |             
                                            __________________________________________________________________________|             
   Uterus                                  |    +  +  +  +     +                 +  +        +     +              +  +|             
      Endometrium, Hyperplasia, Cystic,    |                                                                          |             
           Glandular                       |       2     2     3                 3  3                             3  3|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +  +  +                                +     +     +              +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +  +  +  +  +        +           +     +  +  +     +           M  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |    +  +     +                       +     +  +                    M  +  +|             
      Hematopoietic Cell Proliferation     |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +     +                       +  +  +     +  +  +     +  +  +|             
      Hematopoietic Cell Proliferation     |                                                 3     3                  |             
      Hyperplasia, Lymphoid                |                   2                                               4      |             
      Necrosis, Acute                      |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  |    +  +  M                                +     +     +              +  +|             
      Depletion Lymphoid                   |       2                                                                  |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    M  +  +                                +  +  +     +              +  +|             
                                            __________________________________________________________________________|             
   Skin                                    |    +  +  +                                +     +     +              +  +|             
      Acanthosis                           |    2  2  2                                                               |             
      Parasite External                    |    X  X  X                                                           X  X|             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic Active                  |    2                                                                     |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +  +  +                                +     +     +              +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  28                                                               
NTP Experiment-Test: 05076-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 18:14:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 6| 7| 7| 7| 7| 6| 6|             
                             DAY ON TEST   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 6| 4| 8| 4| 0| 4| 4| 4| 4| 9| 8|             
                                           | 0| 8| 7| 8| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 0| 2| 8| 2| 5| 2| 2| 3| 3| 8| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    333 PPM                                | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
      3-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +  +  +                                +     +     +              +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Peribronchiolar, Inflammation,       |                                                                          |             
          Chronic Active                   |                                  2                                       |             
                                            __________________________________________________________________________|             
   Nose                                    |    +  +  +                                +     +     +              +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 |    +  +  +                                +     +     +              +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Atrophy                              |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |    +  +  +                                +     +     +              +  +|             
      Renal Tubule, Dilatation             |                                                       3                  |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    M  +  +                                +     +     +              +  +|             
      Inflammation, Chronic Active         |                                                 2                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  29                                                               
NTP Experiment-Test: 05076-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 18:14:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 4| 7| 4| 0| 4| 4| 4| 4| 2| 4| 0| 4| 4| 4| 6| 4| 4| 8| 4| 4| 4| 5| 5| 4| 5|            |
                                           | 3| 7| 3| 6| 3| 7| 7| 7| 1| 7| 9| 8| 8| 8| 3| 1| 9| 8| 9| 9| 9| 0| 0| 9| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    333 PPM                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      L     |
      3-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |    +     +              +     +           +  +     +                 +   |  16        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |    +     A              +     +           A  M     +                 A   |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |    +     +              +     +           +  +     +                 +   |  16        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |    +     +              +     +           +  A     +                 A   |  14        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |    +     +              +     +           +  +     +                 +   |  16        |
      Parasite Metazoan                    |          X                                                               |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |    +     +              +     +           +  A     +                 +   |  14        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |    +     +        +     +     +        +  +  +     +                 +   |  19        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |    +     +              +     +           +        +                 A   |  14        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |    +     +              +     +           M        +                 A   |  13        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |    +     +        +     +     +        +  +  +     +                 +   |  19        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     |                   X                    X                                 |      2     |
      Eosinophilic Focus                   |                            X                    X     X                  |      4     |
      Fatty Change, Focal                  |                                                                   1      |      1  1.0|
      Hematopoietic Cell Proliferation     |                                                                          |      4  2.8|
      Infarct                              |          3              3                 3                 4            |      6  3.0|
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
      Centrilobular, Cytomegaly            |             2                       1                       1            |      8  1.5|
      Centrilobular, Necrosis, Acute       |          3                                                               |      1  3.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   1        |
      Inflammation, Chronic Active         |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                |    +     +              +     +           +  +     +                 A   |  16        |
      Acinus, Atrophy                      |                                                                          |      1  3.0|
      Duct, Ectasia                        |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |    +     +              +     +           +  +     +                 M   |  15        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |    +     +              +     +           +  A     +           +     +   |  17        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |    +     +              +     +           +  A     +           +     +   |  17        |
      Diverticulum                         |                                                                          |      1  2.0|
      Hyperplasia, Squamous                |                                           1                    2         |      3  1.7|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |    +     +              +     +           +  A     +                 +   |  15        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |    +     +              +     +           +  +     +                 +   |  16        |
      Bacterium, Acute, Multiple           |                                                    3                 3   |      2  3.0|
      Degeneration, Chronic                |                                                                          |      1  4.0|
      Inflammation, Acute                  |          2                                         3                     |      2  2.5|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  30                                                               
NTP Experiment-Test: 05076-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 18:14:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 4| 7| 4| 0| 4| 4| 4| 4| 2| 4| 0| 4| 4| 4| 6| 4| 4| 8| 4| 4| 4| 5| 5| 4| 5|            |
                                           | 3| 7| 3| 6| 3| 7| 7| 7| 1| 7| 9| 8| 8| 8| 3| 1| 9| 8| 9| 9| 9| 0| 0| 9| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    333 PPM                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      L     |
      3-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |    +     +              +     +           +  +     +                 +   |  16        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |    +     +              +     +           +  +     +                 +   |  16        |
      Hypertrophy                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |    +     +              +     +           +  +     +                 +   |  16        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |    +     +              +     +           +  +     +                 A   |  15        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |    +     +              +     +           +  +     +                 +   |  15        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Pars Distalis, Hyperplasia           | 2           2        2     3  2  2  2  2  2  2              2     2     2|     23  2.2|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Follicular Cell, Hyperplasia         | 2              2  1  2  2  1           2        2        3     2         |     17  2.0|
      Follicular Cell, Vacuolization       |                                                                          |            |
          Cytoplasmic                      | 3  3  3  3  2  3  3  3  3  3  2  3  3  3  2  2  4  2  3  4  2  4  3     2|     49  2.8|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |                                           +                              |   1        |
      Dilatation                           |                                           3                              |      1  3.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   |    +     +              +     +  +        +  +  +  +           +  +  +  +|  24        |
      Follicle, Cyst                       |          X                    X  X              X              X        X|     11     |
      Periovarian Tissue, Cyst             |                                                 X                 X      |      3     |
                                            __________________________________________________________________________|____________|
   Uterus                                  |    +     +              +     +           +  +     +              +  +   |  20        |
      Endometrium, Hyperplasia, Cystic,    |                                                                          |            |
           Glandular                       |                                                                   3      |      8  2.8|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |    +     +              +     +           +  +     +                 +   |  16        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |    +     A        +     +     +           +  +  +  +  +     +        +  +|  25        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |          A        +           +              +  +           +        +   |  14        |
      Hematopoietic Cell Proliferation     |                                                 2                        |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  |    +  +  +  +     +     +  +  +        +  +  +  +  +  +              +  +|  31        |
      Hematopoietic Cell Proliferation     |          3                                2     2                    3   |      6  2.7|
      Hyperplasia, Lymphoid                |                            2                                             |      3  2.7|
      Necrosis, Acute                      |                                                    3                     |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  |    +     M              +     +           +  M     +                 M   |  12        |
      Depletion Lymphoid                   |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  31                                                               
NTP Experiment-Test: 05076-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 18:14:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 4| 7| 4| 0| 4| 4| 4| 4| 2| 4| 0| 4| 4| 4| 6| 4| 4| 8| 4| 4| 4| 5| 5| 4| 5|            |
                                           | 3| 7| 3| 6| 3| 7| 7| 7| 1| 7| 9| 8| 8| 8| 3| 1| 9| 8| 9| 9| 9| 0| 0| 9| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|      A     |
    333 PPM                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      L     |
      3-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |    +     +              +     +           +  +     +                 +   |  16        |
                                            __________________________________________________________________________|____________|
   Skin                                    |    +     +              +     +           +  +     +                 +   |  16        |
      Acanthosis                           |    3     2              2     2           2                              |      8  2.1|
      Parasite External                    |    X     X              X     X           X  X                           |     11     |
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Chronic Active                  |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |    +     +              +     +           +  +     +                 +   |  16        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |    +     +              +     +           +  +     +                 +   |  16        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Alveolar Epithelium, Hyperplasia     |       2                                                                  |      1  2.0|
      Peribronchiolar, Inflammation,       |                                                                          |            |
          Chronic Active                   |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    |    +     +              +     +           +  +     +                 +   |  16        |
                                            __________________________________________________________________________|____________|
   Trachea                                 |    +     +              +     +           +  +     +                 +   |  16        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                 +                        |   1        |
      Atrophy                              |                                                 4                        |      1  4.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                 +                        |   1        |
      Inflammation, Chronic Active         |                                                 4                        |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |    +     +              +     +           +  +     +                 +   |  16        |
      Renal Tubule, Dilatation             |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |    +     +              +     +           +  A     +                 A   |  13        |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  32                                                               
NTP Experiment-Test: 05076-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 18:14:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 0| 3| 2| 9| 4| 4| 3| 1| 4| 4| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 4| 4| 4| 4|             
                                           | 1| 8| 5| 8| 0| 0| 8| 0| 1| 1| 8| 0| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    333 PPM                                | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
      10-3                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +        +  +        +  +                       +  +            |             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +        +  +        +  A                       M  +            |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +        +  +        +  +                       +  +            |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +        +  +        +  +                       +  +            |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +        +  +        +  +                       +  +            |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +        +  +        +  +                       +  +            |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +        +  +        +  +  +                    +  +            |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +        +  +        +  +                       +  +            |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +        +  +        +  +                       +  +            |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +        +  +        +  +  +                    +  +            |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                                                          |             
      Clear Cell Focus                     |                                                                          |             
      Eosinophilic Focus                   |    X                       X                                      X     X|             
      Hematopoietic Cell Proliferation     |          2                                                  3            |             
      Infarct                              | 3                             3                          2               |             
      Inflammation, Acute                  |          3                                                               |             
      Inflammation, Chronic Active         |                                                          1               |             
      Centrilobular, Cytomegaly            |       2     2                       1           1           1  2         |             
                                            __________________________________________________________________________|             
   Mesentery                               |    +                                                                     |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +        +  +        +  +                       +  +  +         |             
      Acinus, Atrophy                      |       3  2                                                               |             
      Duct, Ectasia                        |       3                                                        3         |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +        +  +        +  +                       +  +            |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +        +  +        +  +                       +  +            |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +        +  +        +  +                       +  +            |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +        +  +        +  +                       +  +            |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +        +  +        +  +                       +  +            |             
      Inflammation, Chronic                |                                  2                                       |             
      Interstitium, Hyperplasia, Diffuse   |          3                                                               |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +        +  +        +  +                       +  +            |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +        +           +  +                       +  +            |             
      Hypertrophy                          |                   3                                                      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +        +           +  +                       +  +            |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +        +  +        +  +                       +  +            |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +        +  +        +  +                       +  +            |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +|             
      Pars Distalis, Hyperplasia           |       2        2           2     2        3  2        3     2  3         |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  33                                                               
NTP Experiment-Test: 05076-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 18:14:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 0| 3| 2| 9| 4| 4| 3| 1| 4| 4| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 4| 4| 4| 4|             
                                           | 1| 8| 5| 8| 0| 0| 8| 0| 1| 1| 8| 0| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    333 PPM                                | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
      10-3                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Follicular Cell, Hyperplasia         |          2  2     2           2     3     2  2  3  2                    2|             
      Follicular Cell, Vacuolization       |                                                                          |             
          Cytoplasmic                      | 2  3  2  2  2  2  2  1  3  3  2  3  3  3  3  2  3  3  3  2  2  2  3  3  3|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +     +  +  +  +  +  +  +        +  +        +  +  +         |             
      Hemorrhage                           |                         4                                                |             
      Inflammation, Suppurative            |       4  4                                                               |             
      Follicle, Cyst                       |    X  X     X              X        X           X                        |             
      Periovarian Tissue, Cyst             |                                              X                 X         |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +        +  +        +  +     +  +     +        +  +  +         |             
      Angiectasis                          |                                        2                                 |             
      Dilatation                           |       3           2                                                      |             
      Endometrium, Hyperplasia, Cystic,    |                                                                          |             
           Glandular                       |                               2        2  3     3        1     3         |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +        +  +        +  +                       +  +            |             
      Femoral, Hyperplasia, Neutrophil     |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +        +  +        +  +     +                 +  +        +   |             
      Mandibular, Hyperplasia, Lymphoid    |                                        2                                 |             
      Mandibular, Hyperplasia, Reticulum   |                                                                          |             
          Cell                             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +        +        +  +                                               +   |             
      Hematopoietic Cell Proliferation     |          3                                                               |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +        +  +  +  +  +  +  +  +  +  +     +     +  +  +     +  +|             
      Fibrosis                             |                                  2                                       |             
      Hematopoietic Cell Proliferation     |    2                                                                     |             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  +  +        M  +        M  +                       M  M            |             
      Depletion Lymphoid                   |          3                                                               |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +        +  +        +  +                       M  M            |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +        +  +        +  +                       +  +            |             
      Parasite External                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +        +  +        +  +                       +  +            |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  34                                                               
NTP Experiment-Test: 05076-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 18:14:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 0| 3| 2| 9| 4| 4| 3| 1| 4| 4| 3| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 4| 4| 4| 4|             
                                           | 1| 8| 5| 8| 0| 0| 8| 0| 1| 1| 8| 0| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    333 PPM                                | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
      10-3                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +        +  +        +  +                       +  +            |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar Epithelium, Hyperplasia     |                               2                                          |             
      Peribronchiolar, Inflammation,       |                                                                          |             
          Chronic Active                   |       2                                                                  |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +        +  +        +  +                       +  +            |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +        +  +        +  +                          +            |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |    +                                                                     |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +        +  +        +  +                       +  +            |             
      Glomerulus, Inflammation, Acute      |          3                                                               |             
      Glomerulus, Inflammation, Chronic    |                                  2                                       |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +        +  +        +  +                       +  +            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  35                                                               
NTP Experiment-Test: 05076-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 18:14:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7|            |
                             DAY ON TEST   | 3| 4| 4| 4| 4| 4| 6| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 4| 4| 5| 5| 5| 5| 1| 5|            |
                                           | 4| 3| 7| 7| 7| 7| 5| 7| 8| 8| 8| 8| 8| 9| 9| 9| 0| 9| 9| 0| 0| 0| 0| 9| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    333 PPM                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      L     |
      10-3                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +                 +                             +                    +   |  14        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | A                 A                             A                    A   |   8        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +                 +                             A                    A   |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +                 A                             A                    A   |  11        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +                 +                             A                    A   |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +                 A                             A                    A   |  11        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +                 A                             A                    +   |  13        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +                 A                             A                    A   |  11        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +                 A                             A                    A   |  11        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +                 A                             A                    +   |  13        |
      Necrosis                             |                                                                      4   |      1  4.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     |                                                             X            |      1     |
      Clear Cell Focus                     |                               X                                          |      1     |
      Eosinophilic Focus                   |       X        X        X  X  X  X           X        X        X        X|     14     |
      Hematopoietic Cell Proliferation     |                                                                          |      2  2.5|
      Infarct                              |                                                 3                        |      4  2.8|
      Inflammation, Acute                  |                                                                          |      1  3.0|
      Inflammation, Chronic Active         |                                                                          |      1  1.0|
      Centrilobular, Cytomegaly            |                                        2                 2              2|      9  1.7|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +                 A                             A                    +   |  13        |
      Acinus, Atrophy                      |                                                                          |      2  2.5|
      Duct, Ectasia                        |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +                 +                             +                    +   |  14        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +                 +              +              +                    A   |  14        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +                 +              +              +                    A   |  14        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +                 +                             +                    A   |  13        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +                 +                             +                    +   |  14        |
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Interstitium, Hyperplasia, Diffuse   |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | I                 +                             +                    A   |  12        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | I                 +                             +                    A   |  11        |
      Hypertrophy                          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | I                 +                             +                    A   |  11        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  36                                                               
NTP Experiment-Test: 05076-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 18:14:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7|            |
                             DAY ON TEST   | 3| 4| 4| 4| 4| 4| 6| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 4| 4| 5| 5| 5| 5| 1| 5|            |
                                           | 4| 3| 7| 7| 7| 7| 5| 7| 8| 8| 8| 8| 8| 9| 9| 9| 0| 9| 9| 0| 0| 0| 0| 9| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    333 PPM                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      L     |
      10-3                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +                 A                             A                    +   |  12        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M                 +                             +                    M   |  12        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|  47        |
      Pars Distalis, Hyperplasia           |    2                    2     2  2        2        2     2  3     2      |     18  2.2|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Follicular Cell, Hyperplasia         |       2  2     3     2                 2     2     2  3  2     2  2     3|     22  2.2|
      Follicular Cell, Vacuolization       |                                                                          |            |
          Cytoplasmic                      |    2     3  2  2  1  3  3  3  3  3  2     3  3           2  3  2  3  1  3|     44  2.5|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +              M                             +        +  +     +  +  +|  25        |
      Hemorrhage                           |                                                                          |      1  4.0|
      Inflammation, Suppurative            |                                                                          |      2  4.0|
      Follicle, Cyst                       | X                                                           X            |      8     |
      Periovarian Tissue, Cyst             |                                                                   X     X|      4     |
                                            __________________________________________________________________________|____________|
   Uterus                                  |                   +     +     +           +  +  +                    A   |  20        |
      Angiectasis                          |                         2                                                |      2  2.0|
      Dilatation                           |                                                                          |      2  2.5|
      Endometrium, Hyperplasia, Cystic,    |                                                                          |            |
           Glandular                       |                               2           2  3                           |      9  2.3|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +                 +                             A                    +   |  13        |
      Femoral, Hyperplasia, Neutrophil     |                                                                      3   |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | M              +  +     +                 +     +  +              +  A   |  19        |
      Mandibular, Hyperplasia, Lymphoid    |                                                                          |      1  2.0|
      Mandibular, Hyperplasia, Reticulum   |                                                                          |            |
          Cell                             |                         3                                                |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                +                          +        +              +      |   9        |
      Hematopoietic Cell Proliferation     |                                                                          |      1  3.0|
      Inflammation, Chronic Active         |                4                                                         |      1  4.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +           +  +  +        +     +  +  +     +     +  +        +  +  M|  34        |
      Fibrosis                             |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     |                      3                 3  3                          4   |      5  3.0|
      Hyperplasia, Lymphoid                |                               2                       4  4               |      3  3.3|
                                            __________________________________________________________________________|____________|
   Thymus                                  | M                 M                             M                    M   |   5        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  37                                                               
NTP Experiment-Test: 05076-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 18:14:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 7|            |
                             DAY ON TEST   | 3| 4| 4| 4| 4| 4| 6| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 4| 4| 5| 5| 5| 5| 1| 5|            |
                                           | 4| 3| 7| 7| 7| 7| 5| 7| 8| 8| 8| 8| 8| 9| 9| 9| 0| 9| 9| 0| 0| 0| 0| 9| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    333 PPM                                | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      L     |
      10-3                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Depletion Lymphoid                   |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +                 +                             M                    +   |  11        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +                 +                             +                 +  +   |  15        |
      Parasite External                    |                                                                      X   |      1     |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +                 +                             +                    +   |  14        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +                 +                             +                    +   |  14        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Alveolar Epithelium, Hyperplasia     |                                                                          |      1  2.0|
      Peribronchiolar, Inflammation,       |                                                                          |            |
          Chronic Active                   |                                                                         2|      2  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | M                 +                             +                    +   |  13        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | M                 +                             +                    A   |  11        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +                 +                             +                 +  +   |  15        |
      Glomerulus, Inflammation, Acute      |                                                                          |      1  3.0|
      Glomerulus, Inflammation, Chronic    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +                 A                             A                    A   |  11        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  38                                                               
NTP Experiment-Test: 05076-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 18:14:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 7| 7| 0| 6| 6| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 5| 4| 4| 4| 4| 4| 4| 1| 7| 5| 4| 4| 1| 1| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                                           | 7| 0| 0| 0| 0| 1| 1| 3| 4| 3| 1| 1| 4| 9| 2| 2| 2| 2| 3| 3| 3| 3| 0| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1000 PPM                               | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
       0-10                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  M  +  M  +  +  +  +  +  M  +  +  A  M  +  +  +  +  +  +  +  +  M  +  M|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                              X     X                     |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Eosinophilic Focus                   |                                                             X  X         |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Infarct                              |       2     2  3  3     3           3                 2        2         |             
      Mixed Cell Focus                     |                                                                          |             
      Centrilobular, Vacuolization         |                                                                          |             
          Cytoplasmic                      |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                         +                                         +      |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |                                                          4               |             
      Duct, Ectasia                        |                                                          3               |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                      2   |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |             2                                                            |             
      Diverticulum                         |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                         3                                                |             
      Mineralization                       |    3                                                                     |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                      X                                                   |             
      Hematopoietic Cell Proliferation     |                                                                   3      |             
      Hypertrophy                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  39                                                               
NTP Experiment-Test: 05076-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 18:14:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 7| 7| 0| 6| 6| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 5| 4| 4| 4| 4| 4| 4| 1| 7| 5| 4| 4| 1| 1| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                                           | 7| 0| 0| 0| 0| 1| 1| 3| 4| 3| 1| 1| 4| 9| 2| 2| 2| 2| 3| 3| 3| 3| 0| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1000 PPM                               | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
       0-10                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage, Chronic                  |                         3                                                |             
      Hyperplasia                          |    3                                                                     |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  M  +  +  M  +  +  +  +  +  M  +  +  M  +  M  M  M  +  M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Hyperplasia           |    3        2  3        3     3     2  2  3  2  3  3  2  3  3  3  2      |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Hyperplasia         | 4  2  3  4  2  3  3     4  4  3  4     2     3  3  3  3     3  3  3  2  3|             
      Follicular Cell, Vacuolization       |                                                                          |             
          Cytoplasmic                      | 1  2  2  3  3     2  2  3  3  3  3  3  3     3  1  2  3  2  3  3     3  3|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Tubular                 |                                                       2                  |             
      Follicle, Cyst                       |    X  X     X     X                                   X  X               |             
      Periovarian Tissue, Cyst             |                                  X                                       |             
      Periovarian Tissue, Hyperplasia,     |                                                                          |             
           Lymphoid                        |                                                                      2   |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +   |             
      Dilatation                           |                               4                                          |             
      Endometrium, Hyperplasia, Cystic,    |                                                                          |             
           Glandular                       |                                                       2  2               |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +|             
      Femoral, Hyperplasia, Neutrophil     |                                                                      4   |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mandibular, Hyperplasia, Lymphoid    | 2                                                        2  2        2   |             
      Mediastinal, Hyperplasia, Lymphoid   |                                                          2               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                                     +                 +           +      |             
      Inflammation, Chronic Active         |                                                                   4      |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Hyperplasia, Lymphoid                | 2                                                        2  2        2   |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  M  +  +  +  M  M  +  M  M  +  M  M  M  M  +  M  +  M  M  M  M  M  +  M|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  +  +  +  +  M  +  +  M  +  M  +  M  M  +  +  M  +  +  +  +  +  M  M  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                2  1                                         2  2  2  2  2|             
      Parasite External                    |                X  X           X                       X  X  X  X  X  X  X|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  40                                                               
NTP Experiment-Test: 05076-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 18:14:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 7| 7| 0| 6| 6| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 5| 4| 4| 4| 4| 4| 4| 1| 7| 5| 4| 4| 1| 1| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                                           | 7| 0| 0| 0| 0| 1| 1| 3| 4| 3| 1| 1| 4| 9| 2| 2| 2| 2| 3| 3| 3| 3| 0| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    1000 PPM                               | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
       0-10                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Lip, Inflammation, Chronic           |                                  2                                       |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic Active                  |                      2                                            4      |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |          2                       3                                       |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                | 2                                                        2  2        2   |             
      Alveolar Epithelium, Hyperplasia     |                                                       2                  |             
      Peribronchiolar, Inflammation,       |                                                                          |             
          Chronic Active                   |                   2  2  4     2                 2              2         |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mucosa, Inflammation, Acute          |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |    +                                                                     |             
      Atrophy                              |    4                                                                     |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |    +                                                           +         |             
      Inflammation, Chronic Active         |                                                                4         |             
      Acinus, Dilatation                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy, Chronic                 |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Hyperplasia, Lymphoid                |                                                          2           2   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  41                                                               
NTP Experiment-Test: 05076-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 18:14:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 6| 7| 7| 4| 6| 7| 6| 7| 7| 5| 7| 7| 6| 7| 7| 7| 6| 6| 6| 7|            |
                             DAY ON TEST   | 4| 9| 4| 4| 4| 9| 3| 3| 9| 9| 4| 9| 4| 2| 3| 4| 4| 9| 5| 5| 5| 6| 1| 6| 5|            |
                                           | 7| 1| 8| 8| 8| 1| 5| 3| 9| 1| 9| 7| 9| 6| 9| 9| 9| 8| 0| 0| 0| 3| 1| 3| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    1000 PPM                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      L     |
       0-10                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  M  +  +  +  +  +  +  +  +  +  M  +  A  +  M  +  +  +  +  +  +  +  +|  39        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |                                                    3                     |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    | X                                                                        |      3     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |             2                                                            |      1  2.0|
      Eosinophilic Focus                   |             X                                                            |      3     |
      Hematopoietic Cell Proliferation     |                                                                   3      |      1  3.0|
      Hyperplasia, Lymphoid                |                                                    2                     |      1  2.0|
      Infarct                              |       2                 3              3     2                    3      |     13  2.5|
      Mixed Cell Focus                     |                                                          X               |      1     |
      Centrilobular, Vacuolization         |                                                                          |            |
          Cytoplasmic                      |                                        4                                 |      1  4.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acinus, Atrophy                      |                                                                          |      1  4.0|
      Duct, Ectasia                        |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Acanthosis                           |                                                                          |      1  2.0|
      Diverticulum                         |                                                                         2|      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic                |                                                                          |      1  3.0|
      Mineralization                       |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  42                                                               
NTP Experiment-Test: 05076-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 18:14:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 6| 7| 7| 4| 6| 7| 6| 7| 7| 5| 7| 7| 6| 7| 7| 7| 6| 6| 6| 7|            |
                             DAY ON TEST   | 4| 9| 4| 4| 4| 9| 3| 3| 9| 9| 4| 9| 4| 2| 3| 4| 4| 9| 5| 5| 5| 6| 1| 6| 5|            |
                                           | 7| 1| 8| 8| 8| 1| 5| 3| 9| 1| 9| 7| 9| 6| 9| 9| 9| 8| 0| 0| 0| 3| 1| 3| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    1000 PPM                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      L     |
       0-10                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Accessory Adrenal Cortical Nodule    |                                                                          |      1     |
      Hematopoietic Cell Proliferation     |                                                                          |      1  3.0|
      Hypertrophy                          |       2                                                                  |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage, Chronic                  |                                                                          |      1  3.0|
      Hyperplasia                          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  M  +  M  +  +  +  M  M  M  +  +  +  M  +  +  M  +  +  M  M  +  +  +  +|  31        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Pars Distalis, Hyperplasia           |       3     2     2     2     3           3  2     2        3  3        3|     27  2.6|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Follicular Cell, Hyperplasia         | 3  3  3  3  3  3  2  3  2  3  2  3  3  2  2  2  3  2  3  3  2  3  2  3  2|     46  2.8|
      Follicular Cell, Vacuolization       |                                                                          |            |
          Cytoplasmic                      | 2  3  3  2  3  3  3  3  3  3  3  3  3  2  2  3  2  3  3  3  3  3  3  3  3|     47  2.7|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                      +   |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Tubular                 |                                                                          |      1  2.0|
      Follicle, Cyst                       |                   X                                X                     |      8     |
      Periovarian Tissue, Cyst             |                                                             X            |      2     |
      Periovarian Tissue, Hyperplasia,     |                                                                          |            |
           Lymphoid                        |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Dilatation                           |                                                             3            |      2  3.5|
      Endometrium, Hyperplasia, Cystic,    |                                                                          |            |
           Glandular                       |                3        3     2        2              2              3   |      8  2.4|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Femoral, Hyperplasia, Neutrophil     |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  M  +  M  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  47        |
      Mandibular, Hyperplasia, Lymphoid    |                                                                          |      4  2.0|
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +                                                                        |   4        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  43                                                               
NTP Experiment-Test: 05076-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 18:14:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 6| 7| 7| 4| 6| 7| 6| 7| 7| 5| 7| 7| 6| 7| 7| 7| 6| 6| 6| 7|            |
                             DAY ON TEST   | 4| 9| 4| 4| 4| 9| 3| 3| 9| 9| 4| 9| 4| 2| 3| 4| 4| 9| 5| 5| 5| 6| 1| 6| 5|            |
                                           | 7| 1| 8| 8| 8| 1| 5| 3| 9| 1| 9| 7| 9| 6| 9| 9| 9| 8| 0| 0| 0| 3| 1| 3| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    1000 PPM                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      L     |
       0-10                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Chronic Active         |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia, Lymphoid                |    2                                               2                     |      6  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  M  +  M  M  +  +  +  +  +  M  +  M  +  M  M  M  +  M  +  M  M  +|  23        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  +  M  M  +  M  M  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|  33        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Acanthosis                           |                2           3                 2  2  1  2     2  2     2  2|     17  1.9|
      Parasite External                    |    X           X     X     X                 X  X  X        X  X  X  X  X|     22     |
      Lip, Inflammation, Chronic           |                                                                          |      1  2.0|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Chronic Active                  |                                                                          |      2  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression                          |                                                                          |      2  2.5|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Lymphoid                |    2                                                                     |      5  2.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      1  2.0|
      Peribronchiolar, Inflammation,       |                                                                          |            |
          Chronic Active                   |       1                             2                       2            |      9  2.1|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  49        |
      Mucosa, Inflammation, Acute          |                3                                                         |      1  3.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
      Atrophy                              |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                   +  +                                                   |   4        |
      Inflammation, Chronic Active         |                                                                          |      1  4.0|
      Acinus, Dilatation                   |                   3  2                                                   |      2  2.5|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  44                                                               
NTP Experiment-Test: 05076-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 18:14:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 7| 6| 7| 7| 4| 6| 7| 6| 7| 7| 5| 7| 7| 6| 7| 7| 7| 6| 6| 6| 7|            |
                             DAY ON TEST   | 4| 9| 4| 4| 4| 9| 3| 3| 9| 9| 4| 9| 4| 2| 3| 4| 4| 9| 5| 5| 5| 6| 1| 6| 5|            |
                                           | 7| 1| 8| 8| 8| 1| 5| 3| 9| 1| 9| 7| 9| 6| 9| 9| 9| 8| 0| 0| 0| 3| 1| 3| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    1000 PPM                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      L     |
       0-10                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Nephropathy, Chronic                 |                                                 2                        |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia, Lymphoid                |    2                                               2                     |      4  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  45                                                               
NTP Experiment-Test: 05076-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 18:14:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 6| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 6| 7| 7| 2|             
                             DAY ON TEST   | 9| 4| 4| 4| 4| 4| 4| 7| 8| 0| 4| 4| 4| 4| 4| 4| 8| 3| 4| 4| 0| 7| 4| 0| 7|             
                                           | 7| 0| 0| 0| 0| 0| 1| 9| 3| 1| 1| 1| 2| 2| 2| 2| 0| 3| 3| 3| 9| 8| 3| 9| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    1000 PPM                               | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
       10-10                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  A  +  +  +  +  A  +  +  +  +  +  A  +  +  M  +  +  +  M  M  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Eosinophilic Focus                   |                                                       X                  |             
      Hematopoietic Cell Proliferation     |                                                                         3|             
      Infarct                              |    4  2  4     3           3  3        3        4  3           2         |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Histiocyte                      |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Centrilobular, Cytomegaly            |                               3        2                    1            |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                         +|             
      Inflammation, Chronic Active         |                                                                         3|             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |                                                                          |             
      Duct, Ectasia                        |                                                                          |             
      Perivascular, Inflammation, Chronic  |                                                                          |             
          Active                           |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Perivascular, Inflammation, Chronic  |                                                                          |             
          Active, Multifocal               |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                               3                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hypertrophy                          |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  M  M  M  M  M  M  +  M  M  +  +  +  +  +  M  +  +  +  M  M  M  M  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  46                                                               
NTP Experiment-Test: 05076-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 18:14:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 6| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 6| 7| 7| 2|             
                             DAY ON TEST   | 9| 4| 4| 4| 4| 4| 4| 7| 8| 0| 4| 4| 4| 4| 4| 4| 8| 3| 4| 4| 0| 7| 4| 0| 7|             
                                           | 7| 0| 0| 0| 0| 0| 1| 9| 3| 1| 1| 1| 2| 2| 2| 2| 0| 3| 3| 3| 9| 8| 3| 9| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    1000 PPM                               | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
       10-10                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |             X                                                            |             
      Pars Distalis, Hyperplasia           | 3  3  3     2     3  2        3  2        2  2  2              2  2  3   |             
      Pars Distalis, Vacuolization         |                                                                          |             
          Cytoplasmic                      |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Hyperplasia         | 3  4  3  3  3  3  2  1  3  3  3  2  3  3  2  2  3  3  3  3  4  3     3   |             
      Follicular Cell, Vacuolization       |                                                                          |             
          Cytoplasmic                      | 2  2  2  3  2  2  2  4  3  3  3  2  3  3  2  3  3  2  3  2  2  2     2  2|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |          3                                                               |             
      Follicle, Cyst                       |          X                       X                                       |             
      Periovarian Tissue, Cyst             |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |             
      Angiectasis                          |                                                          4               |             
      Dilatation                           | 3                                                        2               |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Inflammation, Chronic Active         |                                  4                                       |             
      Endometrium, Hyperplasia, Cystic,    |                                                                          |             
           Glandular                       |                                        2  2        1                     |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femoral, Hyperplasia, Neutrophil     |                                                                         4|             
      Femoral, Hyperplasia, Reticulum Cell |                                                                   2      |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mandibular, Hyperplasia, Lymphoid    | 2  2                                                                     |             
      Mandibular, Hyperplasia              |                                                                          |             
      Mediastinal, Hyperplasia, Lymphoid   | 2  2                                                                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                      +                 +                    +        +   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                                         3|             
      Hyperplasia, Lymphoid                | 2  2                                                                     |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  M  +  +  +  +  +  +  +  +  M  M  I  M  +  +  +  M  +  +  M  M  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  +  M  M  +  +  +  +  +  M  +  +  +  +  +  M  +  M  +  +  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  47                                                               
NTP Experiment-Test: 05076-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 18:14:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 6| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 5| 7| 6| 7| 7| 7| 7| 6| 7| 7| 2|             
                             DAY ON TEST   | 9| 4| 4| 4| 4| 4| 4| 7| 8| 0| 4| 4| 4| 4| 4| 4| 8| 3| 4| 4| 0| 7| 4| 0| 7|             
                                           | 7| 0| 0| 0| 0| 0| 1| 9| 3| 1| 1| 1| 2| 2| 2| 2| 0| 3| 3| 3| 9| 8| 3| 9| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    1000 PPM                               | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
       10-10                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Cyst Epithelial Inclusion            |                   X                                                      |             
      Parasite External                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                                                    X        X            |             
      Hydrocephalus                        |                2                                            2            |             
      Perivascular, Inflammation, Chronic  |                                                                          |             
          Active                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |    2                                                                     |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Peribronchiolar, Inflammation,       |                                                                          |             
          Chronic Active                   |                2        1                       1        1           2  2|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                           +                              |             
      Atrophy                              |                                           4                              |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |    +                          +                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                | 2  2                                                                     |             
      Nephropathy, Chronic                 |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  48                                                               
NTP Experiment-Test: 05076-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 18:14:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 7| 7| 4| 7| 7| 4| 6| 7| 7| 7| 7| 6| 7| 5| 7| 5| 7| 7| 6| 7|            |
                             DAY ON TEST   | 1| 4| 4| 6| 4| 4| 4| 4| 4| 4| 5| 7| 4| 4| 4| 4| 4| 4| 9| 5| 7| 5| 5| 9| 5|            |
                                           | 2| 7| 7| 3| 7| 7| 8| 3| 8| 8| 7| 7| 8| 9| 9| 9| 2| 9| 8| 0| 0| 0| 0| 7| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|      A     |
    1000 PPM                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      L     |
       10-10                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  M  +  M  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  M  +  +  +  +  +|  39        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | A  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | A  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +|  48        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Eosinophilic Focus                   |                         X                                                |      2     |
      Hematopoietic Cell Proliferation     |                                  2                                       |      2  2.5|
      Infarct                              |    2  3  3  3                 2     2  2        2  2     4  2     2      |     22  2.7|
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Histiocyte                      |                                                                         2|      1  2.0|
      Inflammation, Chronic Active         |                            2                                             |      1  2.0|
      Centrilobular, Cytomegaly            |             1           2     3  1                                   3   |      8  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   1        |
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acinus, Atrophy                      |                                                    4                     |      1  4.0|
      Duct, Ectasia                        |                                                    3                     |      1  3.0|
      Perivascular, Inflammation, Chronic  |                                                                          |            |
          Active                           |                                                                   3      |      1  3.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Perivascular, Inflammation, Chronic  |                                                                          |            |
          Active, Multifocal               |                                                                   3      |      1  3.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acanthosis                           |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Degeneration, Chronic                |                                                             2            |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  49                                                               
NTP Experiment-Test: 05076-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 18:14:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 7| 7| 4| 7| 7| 4| 6| 7| 7| 7| 7| 6| 7| 5| 7| 5| 7| 7| 6| 7|            |
                             DAY ON TEST   | 1| 4| 4| 6| 4| 4| 4| 4| 4| 4| 5| 7| 4| 4| 4| 4| 4| 4| 9| 5| 7| 5| 5| 9| 5|            |
                                           | 2| 7| 7| 3| 7| 7| 8| 3| 8| 8| 7| 7| 8| 9| 9| 9| 2| 9| 8| 0| 0| 0| 0| 7| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|      A     |
    1000 PPM                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      L     |
       10-10                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hypertrophy                          |                                                                      2   |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  +  M  M  +  M  M  +  M  M  +  M  M  M  +  +  +  M  +  +  +  M  +  +  +|  24        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|  47        |
      Pars Distalis, Cyst                  |                                                                          |      1     |
      Pars Distalis, Hyperplasia           | 2  2     1  3              2  3     3  3     3  2        3  2  3        3|     28  2.5|
      Pars Distalis, Vacuolization         |                                                                          |            |
          Cytoplasmic                      |                                        2                       2         |      2  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Follicular Cell, Hyperplasia         | 2  2  3  3  4  3  4  2  3  2  3  3  4  3  3  3  3  3  3  3     3  3  4   |     46  2.9|
      Follicular Cell, Vacuolization       |                                                                          |            |
          Cytoplasmic                      | 2  2  2  3  3  2  1  2  2  3  3  3  2     3  3  3  3  3  3  3  1  3  2  3|     48  2.5|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +|  48        |
      Inflammation, Suppurative            |                                                                          |      1  3.0|
      Follicle, Cyst                       |       X           X                 X        X           X               |      7     |
      Periovarian Tissue, Cyst             |                            X                                      X      |      2     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Angiectasis                          |                                                                   2      |      2  3.0|
      Dilatation                           |       2                          3              2                        |      5  2.4|
      Hyperplasia, Lymphoid                |                                        2                                 |      1  2.0|
      Inflammation, Chronic Active         |                                                                   3      |      2  3.5|
      Endometrium, Hyperplasia, Cystic,    |                                                                          |            |
           Glandular                       |                         2  3        2  2  2              2           2  2|     11  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Femoral, Hyperplasia, Neutrophil     |                                                                          |      1  4.0|
      Femoral, Hyperplasia, Reticulum Cell |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Mandibular, Hyperplasia, Lymphoid    |                                                                          |      2  2.0|
      Mandibular, Hyperplasia              |                                        2                                 |      1  2.0|
      Mediastinal, Hyperplasia, Lymphoid   |                                        2                                 |      3  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  50                                                               
NTP Experiment-Test: 05076-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 18:14:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 7| 7| 4| 7| 7| 4| 6| 7| 7| 7| 7| 6| 7| 5| 7| 5| 7| 7| 6| 7|            |
                             DAY ON TEST   | 1| 4| 4| 6| 4| 4| 4| 4| 4| 4| 5| 7| 4| 4| 4| 4| 4| 4| 9| 5| 7| 5| 5| 9| 5|            |
                                           | 2| 7| 7| 3| 7| 7| 8| 3| 8| 8| 7| 7| 8| 9| 9| 9| 2| 9| 8| 0| 0| 0| 0| 7| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|      A     |
    1000 PPM                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      L     |
       10-10                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +                    +           +                          +     +      |   9        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hematopoietic Cell Proliferation     |                                                                          |      1  3.0|
      Hyperplasia, Lymphoid                |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  +  +  +  M  +  +  M  +  +  M  +  M  M  +  +  +  +  M  +  M  +  M  +  +|  33        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  +  M  +  M  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +|  37        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acanthosis                           |    2  2     3                                1     2  2  2               |      7  2.0|
      Cyst Epithelial Inclusion            |                                                                          |      1     |
      Parasite External                    |    X  X     X                                X     X  X  X               |      7     |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Compression                          |                                                                          |      2     |
      Hydrocephalus                        |                                                                          |      2  2.0|
      Perivascular, Inflammation, Chronic  |                                                                          |            |
          Active                           |                                                                   2      |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia, Lymphoid                |                                        2                                 |      2  2.0|
      Alveolar Epithelium, Hyperplasia     |                                        2                                 |      1  2.0|
      Peribronchiolar, Inflammation,       |                                                                          |            |
          Chronic Active                   |                                                                          |      6  1.5|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |    +                                                                     |   2        |
      Atrophy                              |    4                                                                     |      2  4.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         | +                                                                        |   3        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  51                                                               
NTP Experiment-Test: 05076-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 18:14:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 7| 7| 4| 7| 7| 4| 6| 7| 7| 7| 7| 6| 7| 5| 7| 5| 7| 7| 6| 7|            |
                             DAY ON TEST   | 1| 4| 4| 6| 4| 4| 4| 4| 4| 4| 5| 7| 4| 4| 4| 4| 4| 4| 9| 5| 7| 5| 5| 9| 5|            |
                                           | 2| 7| 7| 3| 7| 7| 8| 3| 8| 8| 7| 7| 8| 9| 9| 9| 2| 9| 8| 0| 0| 0| 0| 7| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|      A     |
    1000 PPM                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      L     |
       10-10                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia, Lymphoid                |                                                                          |      2  2.0|
      Nephropathy, Chronic                 |                               3                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  52                                                               
NTP Experiment-Test: 05076-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 18:14:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 3| 7| 7| 2| 1| 7| 3| 7| 7| 5| 1| 7| 7| 7| 6| 7| 5| 7| 7| 6| 7| 7| 6| 7|             
                             DAY ON TEST   | 8| 0| 4| 4| 8| 8| 4| 1| 4| 4| 2| 7| 4| 4| 4| 6| 0| 6| 4| 4| 5| 4| 4| 7| 4|             
                                           | 3| 2| 3| 3| 1| 4| 3| 1| 4| 4| 0| 8| 4| 4| 5| 2| 5| 6| 5| 5| 6| 5| 6| 2| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    0-0                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  A  +  +  +  +  +  A  +  +  M  A  M  M  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                   1      |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  A  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |             X           X                       X                        |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  A  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                    4                     |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     | X                 X     X                                                |             
      Clear Cell Focus                     |                                                                          |             
      Eosinophilic Focus                   |                   X                                                      |             
      Fatty Change, Focal                  |                                                                      3   |             
      Hematopoietic Cell Proliferation     |                                                    2                     |             
      Infarct                              |       2                       3     3  3     3           3     3         |             
      Inflammation, Chronic Active         |                                                                2         |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                    +                 +   |             
      Angiectasis                          |                                                                          |             
      Inflammation, Chronic Active         |                                                    3                     |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |                                              4                          1|             
      Acinus, Focal Cellular Change        |                                                                          |             
      Duct, Cyst                           |                                              4                           |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                         1                                                |             
      Acinus, Atrophy                      |                            1                                             |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
      Acanthosis                           |                                                          2               |             
      Inflammation, Acute                  |                                                          2               |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                      +  +|             
      Incisor, Upper, Dysplasia            |                                                                         1|             
      Peridontal Tissue, Infiltration      |                                                                          |             
          Cellular, Mast Cell              |                                                                          |             
      Peridontal Tissue, Inflammation,     |                                                                          |             
           Suppurative                     |                                                                      2   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  53                                                               
NTP Experiment-Test: 05076-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 18:14:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 3| 7| 7| 2| 1| 7| 3| 7| 7| 5| 1| 7| 7| 7| 6| 7| 5| 7| 7| 6| 7| 7| 6| 7|             
                             DAY ON TEST   | 8| 0| 4| 4| 8| 8| 4| 1| 4| 4| 2| 7| 4| 4| 4| 6| 0| 6| 4| 4| 5| 4| 4| 7| 4|             
                                           | 3| 2| 3| 3| 1| 4| 3| 1| 4| 4| 0| 8| 4| 4| 5| 2| 5| 6| 5| 5| 6| 5| 6| 2| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    0-0                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bacterium, Acute, Multiple           |    4                                                                     |             
      Mineralization                       |                               1                                          |             
      Valve, Inflammation, Suppurative     |    2                                                                     |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Corticomedullary Junction, Cyst      |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                            1  1                          2        2      |             
      Hypertrophy                          |                         2  1                                      1     2|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                1         |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                                                          +               |             
      Inflammation, Chronic Active         |                                                          3               |             
      Inflammation, Suppurative            |                                                                          |             
      Duct, Dilatation                     |                                                          3               |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            | 3              3                 3                                       |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +              +                                                     +  +|             
      Dilatation                           |                2                                                        3|             
      Inflammation, Suppurative            | 2                                                                        |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Seminiferous Tubule, Degeneration    |             2                                                            |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femoral, Hyperplasia, Neutrophil     |                                                    4                     |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                                     +           +     +              +   |             
      Hematopoietic Cell Proliferation     |                                     3           2                        |             
      Thrombosis                           |                                     X                                    |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  54                                                               
NTP Experiment-Test: 05076-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 18:14:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 3| 7| 7| 2| 1| 7| 3| 7| 7| 5| 1| 7| 7| 7| 6| 7| 5| 7| 7| 6| 7| 7| 6| 7|             
                             DAY ON TEST   | 8| 0| 4| 4| 8| 8| 4| 1| 4| 4| 2| 7| 4| 4| 4| 6| 0| 6| 4| 4| 5| 4| 4| 7| 4|             
                                           | 3| 2| 3| 3| 1| 4| 3| 1| 4| 4| 0| 8| 4| 4| 5| 2| 5| 6| 5| 5| 6| 5| 6| 2| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    0-0                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Depletion Lymphoid                   | 3           1  3                 2                                       |             
      Hematopoietic Cell Proliferation     |                                                 2  3                     |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  M  +     +  M  +  M  M  M  +  +  M  +  M  M  +  +  M  M  M  +  +|             
      Necrosis, Diffuse                    |    3                                                                     |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite External                    |                                                                          |             
      Ulcer                                |                                                                          |             
      Subcutaneous Tissue, Fibrosis        |                                                                         2|             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Acute                           |                3                                                         |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Tarsal, Hyperostosis                 |       X  X                                                  X  X  X  X  X|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infarct                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Metaplasia, Squamous                 |                                  2                                       |             
      Alveolar Epithelium, Hyperplasia     |                                           1     2                        |             
      Peribronchiolar, Inflammation,       |                                                                          |             
          Chronic Active                   | 1  2  1     2     2  2  2  3     3  2  1  1  3  2  3  1        1         |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mucosa, Inflammation, Acute          |                               2                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
      Hyperplasia                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydronephrosis                       | 2                                                                        |             
      Metaplasia, Osseous                  |                                                                1         |             
      Nephropathy, Chronic                 |       2  2  2     1     1  1        1  1  2  1  1     1        1  1     1|             
      Pelvis, Bacterium                    |                                  2                                       |             
      Pelvis, Inflammation, Suppurative    |             1                    2                                       |             
      Renal Tubule, Necrosis               |    2                                                                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  55                                                               
NTP Experiment-Test: 05076-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 18:14:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 3| 7| 7| 2| 1| 7| 3| 7| 7| 5| 1| 7| 7| 7| 6| 7| 5| 7| 7| 6| 7| 7| 6| 7|             
                             DAY ON TEST   | 8| 0| 4| 4| 8| 8| 4| 1| 4| 4| 2| 7| 4| 4| 4| 6| 0| 6| 4| 4| 5| 4| 4| 7| 4|             
                                           | 3| 2| 3| 3| 1| 4| 3| 1| 4| 4| 0| 8| 4| 4| 5| 2| 5| 6| 5| 5| 6| 5| 6| 2| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    0-0                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Urethra                                 | +                                +                                       |             
      Inflammation, Suppurative            | 2                                2                                       |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +|             
      Dilatation                           | 3  1                                                                     |             
      Inflammation, Chronic Active         |             3  3                 3                                       |             
      Mineralization                       |             3                    2                                       |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  56                                                               
NTP Experiment-Test: 05076-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 18:14:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 7| 7| 6| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 6| 7| 7| 4| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 2| 4| 4| 6| 5| 6| 5| 5| 5| 3| 5| 5| 5| 5| 5| 1| 6| 4| 5| 2| 5| 5| 5| 5| 5|            |
                                           | 0| 6| 6| 6| 0| 5| 0| 0| 0| 0| 1| 1| 1| 1| 2| 8| 6| 7| 2| 7| 2| 3| 3| 3| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    0-0                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +|  40        |
      Inflammation, Chronic Active         |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | M  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite Metazoan                    |          X     X                                                         |      5     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | M  +  +  M  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  44        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | A  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
      Inflammation, Chronic Active         |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Basophilic Focus                     |                                                                          |      3     |
      Clear Cell Focus                     |                                     X                                    |      1     |
      Eosinophilic Focus                   |    X                                                                     |      2     |
      Fatty Change, Focal                  |                                                                          |      1  3.0|
      Hematopoietic Cell Proliferation     |                                                 2     2                  |      3  2.0|
      Infarct                              |    3     3     3              3           3     3                       2|     14  2.9|
      Inflammation, Chronic Active         |    2                 2        2        1                                 |      5  1.8|
                                            __________________________________________________________________________|____________|
   Mesentery                               |    +                             +                 +     +               |   6        |
      Angiectasis                          |    4                                                                     |      1  4.0|
      Inflammation, Chronic Active         |                                                          3               |      2  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Acinus, Atrophy                      |             2                    2                 1                     |      5  2.0|
      Acinus, Focal Cellular Change        |                            X                                             |      1     |
      Duct, Cyst                           |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Pharynx                                 |                                           +                              |   1        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Acute                  |                                                                          |      1  1.0|
      Acinus, Atrophy                      |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Acanthosis                           |                                                                          |      1  2.0|
      Inflammation, Acute                  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                  +              +              +         |   5        |
      Incisor, Upper, Dysplasia            |                                  1                             1         |      3  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  57                                                               
NTP Experiment-Test: 05076-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 18:14:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 7| 7| 6| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 6| 7| 7| 4| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 2| 4| 4| 6| 5| 6| 5| 5| 5| 3| 5| 5| 5| 5| 5| 1| 6| 4| 5| 2| 5| 5| 5| 5| 5|            |
                                           | 0| 6| 6| 6| 0| 5| 0| 0| 0| 0| 1| 1| 1| 1| 2| 8| 6| 7| 2| 7| 2| 3| 3| 3| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    0-0                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Peridontal Tissue, Infiltration      |                                                                          |            |
          Cellular, Mast Cell              |                                                 3                        |      1  3.0|
      Peridontal Tissue, Inflammation,     |                                                                          |            |
           Suppurative                     |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Bacterium, Acute, Multiple           |                                                                          |      1  4.0|
      Mineralization                       |                                                                          |      1  1.0|
      Valve, Inflammation, Suppurative     |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Corticomedullary Junction, Cyst      |                                                                   X      |      1     |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                                1     1   |      6  1.3|
      Hypertrophy                          |                         1                 1           1        1         |      8  1.3|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                      1        3                                          |      3  1.7|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | I  +  +  M  +  M  +  +  +  +  I  +  +  +  +  +  M  +  +  +  +  +  +  +  +|  44        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                                                       +                  |   2        |
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
      Inflammation, Suppurative            |                                                       3                  |      1  3.0|
      Duct, Dilatation                     |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Suppurative            |                                                                          |      3  3.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |                                                                          |   4        |
      Dilatation                           |                                                                          |      2  2.5|
      Inflammation, Suppurative            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  58                                                               
NTP Experiment-Test: 05076-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 18:14:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 7| 7| 6| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 6| 7| 7| 4| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 2| 4| 4| 6| 5| 6| 5| 5| 5| 3| 5| 5| 5| 5| 5| 1| 6| 4| 5| 2| 5| 5| 5| 5| 5|            |
                                           | 0| 6| 6| 6| 0| 5| 0| 0| 0| 0| 1| 1| 1| 1| 2| 8| 6| 7| 2| 7| 2| 3| 3| 3| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    0-0                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Seminiferous Tubule, Degeneration    |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                      +                                                   |   1        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Femoral, Hyperplasia, Neutrophil     |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |    +        +     +  +     +  +  +     +           +                    +|  14        |
      Hematopoietic Cell Proliferation     |    3        2     2  2     1  3  2     2                                2|     11  2.2|
      Thrombosis                           |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Depletion Lymphoid                   |                                                                          |      4  2.3|
      Hematopoietic Cell Proliferation     |                                                          4               |      3  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  +  +  M  +  M  +  +  +  +  M  +  +  +  M  I  I  +  M  +  +  +  +  +  M|  29        |
      Necrosis, Diffuse                    |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Parasite External                    |                                     X                                    |      1     |
      Ulcer                                |                                                    2                     |      1  2.0|
      Subcutaneous Tissue, Fibrosis        |                                                                          |      1  2.0|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Acute                           |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Tarsal, Hyperostosis                 |    X  X     X     X  X  X  X  X  X        X           X     X     X  X  X|     22     |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infarct                              |    2                                                                     |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Metaplasia, Squamous                 |                                                                          |      1  2.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      2  1.5|
      Peribronchiolar, Inflammation,       |                                                                          |            |
          Chronic Active                   | 3     1     2           2  1        1     3                    1     2   |     26  1.8|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  59                                                               
NTP Experiment-Test: 05076-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 18:14:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 7| 7| 6| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 6| 7| 7| 4| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 2| 4| 4| 6| 5| 6| 5| 5| 5| 3| 5| 5| 5| 5| 5| 1| 6| 4| 5| 2| 5| 5| 5| 5| 5|            |
                                           | 0| 6| 6| 6| 0| 5| 0| 0| 0| 0| 1| 1| 1| 1| 2| 8| 6| 7| 2| 7| 2| 3| 3| 3| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    0-0                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Mucosa, Inflammation, Acute          | 3                                                                        |      2  2.5|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |          +        +                       +                 +            |   4        |
      Hyperplasia                          |                                           2                              |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hydronephrosis                       |                                                                          |      1  2.0|
      Metaplasia, Osseous                  |                                                                          |      1  1.0|
      Nephropathy, Chronic                 |    2        1     1  1  1  1  2  1  1  1  1  1  2           1  1  1  1   |     32  1.2|
      Pelvis, Bacterium                    |                                                                          |      1  2.0|
      Pelvis, Inflammation, Suppurative    |                                                                          |      2  1.5|
      Renal Tubule, Necrosis               |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urethra                                 |                                                                          |   2        |
      Inflammation, Suppurative            |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Dilatation                           |                                                                          |      2  2.0|
      Inflammation, Chronic Active         |                                                                          |      3  3.0|
      Mineralization                       |                                                                          |      2  2.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  60                                                               
NTP Experiment-Test: 05076-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 18:14:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 1| 6| 7| 3| 6| 7| 7| 7| 7| 0| 0| 0| 0| 0| 7| 7| 5| 7| 7|             
                             DAY ON TEST   | 4| 3| 4| 4| 1| 4| 7| 2| 4| 6| 6| 4| 4| 4| 4| 5| 5| 5| 5| 5| 4| 1| 7| 4| 4|             
                                           | 3| 5| 3| 3| 1| 3| 1| 8| 4| 8| 3| 4| 4| 5| 5| 1| 1| 1| 1| 1| 5| 6| 8| 5| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    10-0                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +        +        +     +  +              +  +  +  +  +     +  +      |             
                                            __________________________________________________________________________|             
   Gallbladder                             |    +        +        +     +  M              A  A  A  A  A     A  +      |             
                                            __________________________________________________________________________|             
   Intestine Large                         |    +        +        +     +  +              +  +  +  +  +     +  +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    +        +        +     +  +              +  +  +  +  +     A  +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +        +        +     +  +              +  +  +  +  +     +  +      |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +        +        +     +  +              +  +  +  +  +     A  +      |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +        +        +     +  +              +  +  +  +  +     A  +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +        +        +     +  +              +  +  +  +  +     A  +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    +        +        +     +  +              +  +  +  +  +     A  +      |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +        +        +     +  +              +  +  +  +  +     A  +      |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                         X                 X                              |             
      Infarct                              |                         3                                   4            |             
      Inflammation, Chronic Active         |                                                                          |             
      Necrosis                             |                                                                          |             
      Bile Duct, Cyst                      |             X                                                            |             
      Centrilobular, Cytomegaly            |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |    +                                                                     |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +        +        +     +  +              +  +  +  +  +     A  +      |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +        +        +     +  +              +  +  +  +  +     +  +      |             
                                            __________________________________________________________________________|             
   Stomach                                 |    +        +        +     +  +        +     +  +  +  +  +     +  +      |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +        +        +     +  +        +     +  +  +  +  +     +  +      |             
      Acanthosis                           |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +        +        +     +  +              +  +  +  +  +     +  +      |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +        +        +     +  +              +  +  +  +  +     +  +      |             
      Thrombosis                           |                      3                                                   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |    +        +        +     +  +              +  +  +  +  +     +  +      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |    +        +        +     +  +              +  +  +  +  +     +  +      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |    +        +        +     +  +              +  +  +  +  +     +  +      |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +        +        +     +  +              +  +  +  +  +     A  +      |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    +        +        +     +  +              M  +  +  M  M     +  +      |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +     +  +  +  +  +  +     +  +  M  +  M  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |                X        X                                                |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Hyperplasia         |                                        2                                 |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  61                                                               
NTP Experiment-Test: 05076-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 18:14:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 1| 6| 7| 3| 6| 7| 7| 7| 7| 0| 0| 0| 0| 0| 7| 7| 5| 7| 7|             
                             DAY ON TEST   | 4| 3| 4| 4| 1| 4| 7| 2| 4| 6| 6| 4| 4| 4| 4| 5| 5| 5| 5| 5| 4| 1| 7| 4| 4|             
                                           | 3| 5| 3| 3| 1| 3| 1| 8| 4| 8| 3| 4| 4| 5| 5| 1| 1| 1| 1| 1| 5| 6| 8| 5| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    10-0                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |    +        +        +     +  +              +  +  +  +  +     +  +      |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                                                                      +   |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                |    +        +        +     +  +              +  +  +  +  +     +  +      |             
      Inflammation, Suppurative            |                            3                                             |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |                                                                          |             
      Dilatation                           |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  |    +        +        +     +  +              +  +  +  +  +     +  +      |             
      Seminiferous Tubule, Degeneration    |             3                                                            |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +        +        +     +  +              +  +  +  +  +     +  +      |             
      Femoral, Hyperplasia, Neutrophil     |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  M  +  +  +        +     +  M        +     +  +  +  M  M     M  +     +|             
      Lumbar, Hyperplasia, Lymphoid        |             2                                                            |             
      Mandibular, Infiltration Cellular,   |                                                                          |             
           Histiocyte                      |                      3                                                   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +     +  +  +                          +                                +|             
      Hematopoietic Cell Proliferation     | 3     3  3                             3                                 |             
      Hyperplasia, Lymphoid                |             2                                                           3|             
                                            __________________________________________________________________________|             
   Spleen                                  |    +        +        +     +  +              +  +  +  +  +  +  +  +      |             
      Depletion Lymphoid                   |                                                                3         |             
      Hematopoietic Cell Proliferation     |                               3                                          |             
      Hyperplasia, Lymphoid                |             2                                                            |             
                                            __________________________________________________________________________|             
   Thymus                                  |    M        +        +     M  M              +  +  +  +  +     M  M      |             
      Depletion Lymphoid                   |                                                                          |             
      Necrosis, Diffuse                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +        +        +     +  +  +        +  +  +  +  +  +     +  +      |             
      Acanthosis                           |                                  3                       3               |             
      Parasite External                    |                      X        X  X                                       |             
      Ulcer                                |                                  2        3                    3         |             
      Subcutaneous Tissue, Edema           |                                                                          |             
      Subcutaneous Tissue, Fibrosis        | 3                                                                        |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Acute                           |                                                                          |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic Active                  | 3                                                        2               |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +        +  +     +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +|             
      Femur, Hyperostosis                  |                                                                          |             
      Tarsal, Hyperostosis                 |             X  X        X     X  X  X  X  X                          X  X|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  62                                                               
NTP Experiment-Test: 05076-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 18:14:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 1| 6| 7| 3| 6| 7| 7| 7| 7| 0| 0| 0| 0| 0| 7| 7| 5| 7| 7|             
                             DAY ON TEST   | 4| 3| 4| 4| 1| 4| 7| 2| 4| 6| 6| 4| 4| 4| 4| 5| 5| 5| 5| 5| 4| 1| 7| 4| 4|             
                                           | 3| 5| 3| 3| 1| 3| 1| 8| 4| 8| 3| 4| 4| 5| 5| 1| 1| 1| 1| 1| 5| 6| 8| 5| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    0 PPM                                  | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    10-0                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +        +        +     +  +              +  +  +  +  +     +  +      |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar Epithelium, Hyperplasia     |                2                                                         |             
      Artery, Embolus                      |                      2                                                   |             
      Peribronchiolar, Inflammation,       |                                                                          |             
          Chronic Active                   |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |    +        +        +     +  +              +  +  +  +  +     +  +      |             
                                            __________________________________________________________________________|             
   Trachea                                 |    +        +        +     +  +              +  +  +  +  +     +  +      |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                      +                    +                              |             
      Cornea, Inflammation, Chronic Active |                                           3                              |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                           +                              |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |    +        +        +     +  +           +  +  +  +  +  +     +  +      |             
      Hydronephrosis                       |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Nephropathy, Chronic                 |             1        2     2                                             |             
      Capsule, Fibrosis, Focal             |                                           3                              |             
      Renal Tubule, Necrosis               |                                                                          |             
                                            __________________________________________________________________________|             
   Urethra                                 |             +                                                            |             
      Inflammation, Suppurative            |                                                                          |             
      Bulbourethral Gland, Dilatation      |             4                                                            |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    +        +        +     +  +              +  +  +  +  +     A  +      |             
      Calculus Gross Observation           |                                                                          |             
      Dilatation                           |                            4                                             |             
      Inflammation, Chronic Active         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  63                                                               
NTP Experiment-Test: 05076-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 18:14:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 3| 3| 7| 3| 7| 7| 7| 7| 7| 2| 2| 3| 3| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 8| 5| 5| 4| 5| 4| 4| 5| 5| 2| 7| 3| 0| 0| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|            |
                                           | 0| 1| 1| 6| 1| 6| 6| 0| 0| 2| 9| 4| 7| 9| 5| 0| 1| 1| 1| 2| 2| 2| 3| 3| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    10-0                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +     +              +  +  +  +  +  +                              |  22        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +     A              +  +  +  A  A  +                              |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +     A              +  +  +  +  +  +                              |  21        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +     A              +  +  +  M  +  +                              |  19        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +     A              +  +  +  +  +  +                              |  21        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +     A              +  +  +  A  +  +                              |  19        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +     M     +        +  +  +  +  +  +                              |  22        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +     A              +  +  +  A  M  +                              |  18        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | A  +  +     A              +  +  +  M  +  +                              |  18        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | A  +  +     A     +        +  +  +  A  +  +                              |  20        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Basophilic Focus                     |                X        X              X                                 |      5     |
      Infarct                              |                                                             3           3|      4  3.3|
      Inflammation, Chronic Active         |                                                                   2      |      1  2.0|
      Necrosis                             |    3  3                                                                  |      2  3.0|
      Bile Duct, Cyst                      |                                              X  X                        |      3     |
      Centrilobular, Cytomegaly            |                   2                                                      |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +     A              +  +  +  +  +  +                              |  20        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +     M              +  +  +  +  +  +                              |  21        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +     A     +        +  +  +  +  +  +  +                           |  24        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +     A     +        +  +  +  +  +  +  +                           |  24        |
      Acanthosis                           |                   3                                                      |      1  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +     A              +  +  +  +  +  +                              |  21        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +     +              +  +  +  +  +  +                              |  23        |
      Thrombosis                           |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +     M              +  +  +  +  +  +                              |  21        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +     M              +  +  +  +  +  +                              |  21        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +     M              +  +  +  +  +  +                              |  21        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +     A              +  +  +  +  +  +                              |  20        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  +  +     +              +  +  +  +  +  M                              |  17        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | I  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +  +  +|  42        |
      Pars Distalis, Cyst                  |                                                                          |      2     |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +  +  +|  46        |
      Follicular Cell, Hyperplasia         |                                              1                           |      2  1.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  64                                                               
NTP Experiment-Test: 05076-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 18:14:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 3| 3| 7| 3| 7| 7| 7| 7| 7| 2| 2| 3| 3| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 8| 5| 5| 4| 5| 4| 4| 5| 5| 2| 7| 3| 0| 0| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|            |
                                           | 0| 1| 1| 6| 1| 6| 6| 0| 0| 2| 9| 4| 7| 9| 5| 0| 1| 1| 1| 2| 2| 2| 3| 3| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    10-0                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +     +              +  +  +  +  +  +                              |  22        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                                        +                                 |   2        |
      Inflammation, Suppurative            |                                        4                                 |      1  4.0|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +     +              +  +  +  +  +  +                              |  22        |
      Inflammation, Suppurative            |                               3        2                                 |      3  2.7|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |                                  +        +                              |   2        |
      Dilatation                           |                                  2        3                              |      2  2.5|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +     +              +  +  +  +  +  +                              |  22        |
      Seminiferous Tubule, Degeneration    |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +     A              +  +  +  +  +  +                              |  21        |
      Femoral, Hyperplasia, Neutrophil     |                                        4                                 |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  M     +        +  +  M  +  +  +  +              +     +      |  25        |
      Lumbar, Hyperplasia, Lymphoid        |                                                                          |      1  2.0|
      Mandibular, Infiltration Cellular,   |                                                                          |            |
           Histiocyte                      |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |          +        +                          +              +     +      |  11        |
      Hematopoietic Cell Proliferation     |          2                                   2              2            |      7  2.6|
      Hyperplasia, Lymphoid                |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +     +     +        +  +  +  A  +  +     +                 +      |  25        |
      Depletion Lymphoid                   |                                                                          |      1  3.0|
      Hematopoietic Cell Proliferation     |                            3                                             |      2  3.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  M  +     M              +  +  M  M  M  M                              |  11        |
      Depletion Lymphoid                   |       3                                                                  |      1  3.0|
      Necrosis, Diffuse                    |                               3                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +     +     +        +  +  +  M  +  +                             +|  26        |
      Acanthosis                           |                                  3                                       |      3  3.0|
      Parasite External                    |                            X                                             |      4     |
      Ulcer                                |                                                                          |      3  2.7|
      Subcutaneous Tissue, Edema           |                                                                         2|      1  2.0|
      Subcutaneous Tissue, Fibrosis        |                                                                          |      1  3.0|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  65                                                               
NTP Experiment-Test: 05076-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 18:14:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 3| 3| 7| 3| 7| 7| 7| 7| 7| 2| 2| 3| 3| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 8| 5| 5| 4| 5| 4| 4| 5| 5| 2| 7| 3| 0| 0| 3| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|            |
                                           | 0| 1| 1| 6| 1| 6| 6| 0| 0| 2| 9| 4| 7| 9| 5| 0| 1| 1| 1| 2| 2| 2| 3| 3| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
    0 PPM                                  | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    10-0                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
           Acute                           |                                           2                              |      1  2.0|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Chronic Active                  |                                                                          |      2  2.5|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +|  44        |
      Femur, Hyperostosis                  |                                              X                           |      1     |
      Tarsal, Hyperostosis                 |          X     X  X  X  X  X                    X     X  X  X  X  X  X  X|     24     |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +     A              +  +  +  +  +  +                              |  21        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Alveolar Epithelium, Hyperplasia     |             2                                                            |      2  2.0|
      Artery, Embolus                      |                                                                          |      1  2.0|
      Peribronchiolar, Inflammation,       |                                                                          |            |
          Chronic Active                   |    2              1     1                          1              2  1   |      6  1.3|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +     A              +  +  +  +  +  +                              |  21        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +     +              +  +  +  +  +  +                              |  22        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   2        |
      Cornea, Inflammation, Chronic Active |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +     +              +  +  +  +  +  +                              |  23        |
      Hydronephrosis                       |                               3           3                              |      2  3.0|
      Inflammation, Chronic Active         |                                        4                                 |      1  4.0|
      Nephropathy, Chronic                 |                                                                          |      3  1.7|
      Capsule, Fibrosis, Focal             |                                                                          |      1  3.0|
      Renal Tubule, Necrosis               |                                  2                                       |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urethra                                 |                                           +                              |   2        |
      Inflammation, Suppurative            |                                           4                              |      1  4.0|
      Bulbourethral Gland, Dilatation      |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +     A              +  +  +  +  +  +                              |  20        |
      Calculus Gross Observation           |                                  X  X                                    |      2     |
      Dilatation                           |                               4     3                                    |      3  3.7|
      Inflammation, Chronic Active         |                                  3     3                                 |      2  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  66                                                               
NTP Experiment-Test: 05076-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 18:14:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 5| 7| 7| 3| 7|             
                             DAY ON TEST   | 4| 4| 3| 4| 4| 4| 4| 4| 4| 1| 4| 4| 4| 4| 2| 4| 4| 5| 5| 5| 9| 0| 5| 4| 5|             
                                           | 3| 3| 2| 3| 3| 4| 4| 1| 4| 6| 5| 5| 5| 6| 4| 6| 6| 0| 0| 0| 3| 5| 0| 5| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    100 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
      1-1                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |       +                    +              +                 +  +     +   |             
                                            __________________________________________________________________________|             
   Gallbladder                             |       A                    +              +                 +  +     +   |             
                                            __________________________________________________________________________|             
   Intestine Large                         |       +                    +              +                 +  +     +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |       +                    +              +                 +  +     A   |             
      Parasite Metazoan                    |                            X                                             |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |       +                    +              +                 +  +     +   |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |       +                    +              +                 +  +     +   |             
                                            __________________________________________________________________________|             
   Intestine Small                         |       +     +              +              +              +  +  +     A   |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |       +                    +              +                 +  +     A   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |       +                    +              +                 +  +     A   |             
      Parasite Metazoan                    |                            X                                             |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |       +     +              +              +              +  +  +     A   |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |    X                                               X                     |             
      Clear Cell Focus                     |                                                                          |             
      Infarct                              |       3  3                                                               |             
      Centrilobular, Cytomegaly            |             1              2                       2  1                  |             
      Centrilobular, Necrosis, Acute       |    2                                                                     |             
                                            __________________________________________________________________________|             
   Pancreas                                |       +                    +              +                 +  +     A   |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |       +                    +              +                 +  +     +   |             
                                            __________________________________________________________________________|             
   Stomach                                 |       +                    +              +                 +  +     A   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |       +                    +              +                 +  +     A   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |       +                    +              +                 +  +     A   |             
      Infiltration Cellular, Lymphocyte    |                                                             2            |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |       +                    +              +                 +  +     +   |             
      Degeneration, Chronic                |                                           3                              |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |       +                    +              +                 +  +     +   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |       +                    +              +                 +  +     +   |             
      Hypertrophy                          |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |       +                    +              +                 +  +     +   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |       +                    +              +                 +  +     A   |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |       +                    +              +                 +  +     +   |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | M  M  +  +  +  +  +     +  +  +  +  I  I  +  +  +  +  +  +  +  M  +  +  +|             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hyperplasia           |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Hyperplasia         |                                                             2            |             
      Follicular Cell, Vacuolization       |                                                                          |             
          Cytoplasmic                      |    1  2  1  1  2  2     2           1  2     2  2  2  2  2  3  2  2  2  2|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  67                                                               
NTP Experiment-Test: 05076-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 18:14:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 5| 7| 7| 3| 7|             
                             DAY ON TEST   | 4| 4| 3| 4| 4| 4| 4| 4| 4| 1| 4| 4| 4| 4| 2| 4| 4| 5| 5| 5| 9| 0| 5| 4| 5|             
                                           | 3| 3| 2| 3| 3| 4| 4| 1| 4| 6| 5| 5| 5| 6| 4| 6| 6| 0| 0| 0| 3| 5| 0| 5| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    100 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
      1-1                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |       +                    +              +                 +  +     +   |             
                                            __________________________________________________________________________|             
   Penis                                   |                                                                +         |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                |       +                    +              +                 +  +     +   |             
                                            __________________________________________________________________________|             
   Testes                                  |       +                    +              +                 +  +     +   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |       +                    +              +                 +  +     +   |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +     +     +              +              +     +        +  +  +  +  +   |             
      Mandibular, Infiltration Cellular,   |                                                                          |             
           Histiocyte                      |                                                                3         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +           +                                   +        +     +  +      |             
      Hematopoietic Cell Proliferation     |                                                 2                        |             
      Hyperplasia, Lymphoid                |                                                                3         |             
      Infiltration Cellular, Plasma Cell   |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  |       +     +              +              +                 +  +     +   |             
      Hematopoietic Cell Proliferation     |                                           3                              |             
                                            __________________________________________________________________________|             
   Thymus                                  |       M     +              M              +                 +  M     +   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |                                                                +         |             
                                            __________________________________________________________________________|             
   Skin                                    |    +  +                    +              +        +        +  +     +   |             
      Acanthosis                           |                                                                3         |             
      Alopecia                             |                                                                          |             
      Hyperplasia, Basal Cell              |                                                                          |             
      Parasite External                    |       X                                                        X         |             
      Subcutaneous Tissue, Fibrosis        |                                                                          |             
      Subcutaneous Tissue, Granuloma       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +     +        +  +  +     +  +  +  +        +  +  +  +  +   |             
      Tarsal, Hyperostosis                 | X  X     X  X     X           X  X     X     X  X        X     X  X      |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |       +                    +              +                 +  +     +   |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar Epithelium, Hyperplasia     |                               1                 1                        |             
      Mediastinum, Inflammation            |                                           2                              |             
      Peribronchiolar, Inflammation,       |                                                                          |             
          Chronic Active                   | 2  2                                                           2     2  1|             
                                            __________________________________________________________________________|             
   Nose                                    |       +                    +              +                 +  +     +   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  68                                                               
NTP Experiment-Test: 05076-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 18:14:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 7| 7| 7| 7| 6| 7| 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 7| 5| 7| 7| 3| 7|             
                             DAY ON TEST   | 4| 4| 3| 4| 4| 4| 4| 4| 4| 1| 4| 4| 4| 4| 2| 4| 4| 5| 5| 5| 9| 0| 5| 4| 5|             
                                           | 3| 3| 2| 3| 3| 4| 4| 1| 4| 6| 5| 5| 5| 6| 4| 6| 6| 0| 0| 0| 3| 5| 0| 5| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    100 PPM                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
      1-1                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 |       +                    +              +                 +  +     +   |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                +                                                         |             
      Atrophy                              |                2                                                         |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |          +     +                 +                                       |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +     +  +                 +              +                 +  +     +   |             
      Capsule, Fibrosis, Focal             |          2                                                               |             
      Cortex, Cyst                         | X                                                                        |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |       +                    +              +                 +  +     +   |             
      Dilatation                           |                                                                      3   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  69                                                               
NTP Experiment-Test: 05076-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 18:14:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 5|                                               |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5|                                               |            |
                                           | 1| 1| 2| 2| 1| 3| 3| 3| 7|                                               |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0|                                               |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0|                                               |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2|                                               |      A     |
    100 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7|                                               |      L     |
      1-1                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4|                                               |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |             +           +                                                |   8        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |             A           +                                                |   6        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |             +           +                                                |   8        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |             +           +                                                |   7        |
      Parasite Metazoan                    |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |             +           +                                                |   8        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |             +           +                                                |   8        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +           +           +                                                |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |             +           +                                                |   7        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |             +           +                                                |   7        |
      Parasite Metazoan                    |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +           +           +                                                |  10        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +                                                |  33        |
      Basophilic Focus                     | X                                                                        |      3     |
      Clear Cell Focus                     |                   X                                                      |      1     |
      Infarct                              |                                                                          |      2  3.0|
      Centrilobular, Cytomegaly            |       2                 1                                                |      6  1.5|
      Centrilobular, Necrosis, Acute       |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                |             +           +                                                |   7        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |             +           +                                                |   8        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |             +           +                                                |   7        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |             +           +                                                |   7        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |             +           +                                                |   7        |
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |             +           +                                                |   8        |
      Degeneration, Chronic                |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |             +           +                                                |   8        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |             +           +                                                |   8        |
      Hypertrophy                          |             2                                                            |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |             +           +                                                |   8        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |             +           +                                                |   7        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |             M           +                                                |   7        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +                                                |  28        |
      Pars Distalis, Cyst                  |                      X                                                   |      1     |
      Pars Distalis, Hyperplasia           |    2                                                                     |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  70                                                               
NTP Experiment-Test: 05076-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 18:14:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 5|                                               |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5|                                               |            |
                                           | 1| 1| 2| 2| 1| 3| 3| 3| 7|                                               |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0|                                               |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0|                                               |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2|                                               |      A     |
    100 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7|                                               |      L     |
      1-1                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4|                                               |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +                                                |  33        |
      Follicular Cell, Hyperplasia         |                                                                          |      1  2.0|
      Follicular Cell, Vacuolization       |                                                                          |            |
          Cytoplasmic                      | 1        2     2  2  2  2                                                |     25  1.8|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              |             +           +                                                |   8        |
                                            __________________________________________________________________________|____________|
   Penis                                   |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |       +                                                                  |   1        |
      Inflammation, Chronic Active         |       3                                                                  |      1  3.0|
                                            __________________________________________________________________________|____________|
   Prostate                                |             +           +                                                |   8        |
                                            __________________________________________________________________________|____________|
   Testes                                  |             +           +                                                |   8        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |             +           +                                                |   8        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +     +     +           +                                                |  15        |
      Mandibular, Infiltration Cellular,   |                                                                          |            |
           Histiocyte                      |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +                                                                        |   7        |
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
      Infiltration Cellular, Plasma Cell   | 2                                                                        |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +     +           +                                                |  12        |
      Hematopoietic Cell Proliferation     | 3                                                                        |      2  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  |             M           M                                                |   4        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |             M                                                            |   1        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +     +  +  +  +        +                                                |  14        |
      Acanthosis                           |       2        3        2                                                |      4  2.5|
      Alopecia                             |                         X                                                |      1     |
      Hyperplasia, Basal Cell              | 4                                                                        |      1  4.0|
      Parasite External                    | X     X     X  X                                                         |      6     |
      Subcutaneous Tissue, Fibrosis        | 3                                                                        |      1  3.0|
      Subcutaneous Tissue, Granuloma       |       3                                                                  |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  71                                                               
NTP Experiment-Test: 05076-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 18:14:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 5|                                               |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5|                                               |            |
                                           | 1| 1| 2| 2| 1| 3| 3| 3| 7|                                               |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0|                                               |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0|                                               |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2|                                               |      A     |
    100 PPM                                | 6| 6| 6| 6| 6| 7| 7| 7| 7|                                               |      L     |
      1-1                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4|                                               |            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |    +  +  +  +  +     +  +                                                |  25        |
      Tarsal, Hyperostosis                 |    X  X  X     X     X                                                   |     18     |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |             +           +                                                |   8        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +                                                |  33        |
      Alveolar Epithelium, Hyperplasia     | 2                                                                        |      3  1.3|
      Mediastinum, Inflammation            |                                                                          |      1  2.0|
      Peribronchiolar, Inflammation,       |                                                                          |            |
          Chronic Active                   |                                                                          |      5  1.8|
                                            __________________________________________________________________________|____________|
   Nose                                    |             +           +                                                |   8        |
                                            __________________________________________________________________________|____________|
   Trachea                                 |             +           +                                                |   8        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
      Atrophy                              |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   3        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |       +     +           +                                                |  11        |
      Capsule, Fibrosis, Focal             |                                                                          |      1  2.0|
      Cortex, Cyst                         |       X                                                                  |      2     |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |             +           +                                                |   8        |
      Dilatation                           |                         3                                                |      2  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  72                                                               
NTP Experiment-Test: 05076-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 18:14:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 0| 7| 7| 6| 7| 7| 7| 7| 7| 7| 2| 7| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 4| 9| 4| 4| 9| 4| 4| 4| 4| 1| 0| 4| 4| 4| 2| 2| 4| 4| 4| 7| 9| 4| 4| 4| 4|             
                                           | 2| 5| 3| 3| 5| 3| 3| 4| 4| 8| 4| 1| 4| 4| 9| 7| 5| 5| 5| 7| 0| 0| 6| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    333 PPM                                | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
      0-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +        +              +  +  +        +  A           +  +  +         |             
                                            __________________________________________________________________________|             
   Gallbladder                             | M  A        A              +  +  +        A  A           +  +  A         |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +        +              +  +  +        +  A           +  +  A         |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +        +              +  +  +        +  A           +  +  A         |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +        +              +  +  +        +  A           +  +  A         |             
      Parasite Metazoan                    | X                                         X                              |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +        +              +  +  +        +  A           +  +  A         |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +        +              +  +  +        +  +           +  +  A         |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +           +              +  +  +        +  A           +  +  A         |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +           +              +  +  +        +  A           +  +  A         |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +           +              +  +  +        +  +           +  +  A         |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |       X                                         X                        |             
      Clear Cell Focus                     |                                                 X     X                  |             
      Eosinophilic Focus                   |                                                    X  X           X  X   |             
      Hematopoietic Cell Proliferation     |                            4                                             |             
      Infarct                              |       3                                                                  |             
      Inflammation, Chronic Active         |                                                                          |             
      Bile Duct, Hyperplasia               |                                                                          |             
      Central Vein, Thrombosis             |                                                                          |             
      Centrilobular, Cytomegaly            |       2  2     2     2  2  3  2     2  2  2     2  2  2  2        2  2  2|             
      Centrilobular, Necrosis, Acute       |                                           2                              |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +        +              +  +  +        +  A           +  +  A         |             
      Acinus, Inflammation, Chronic Active |             3                                                            |             
      Duct, Cyst                           |             4                                                            |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +        +              +  +  +        +  +           +  +  +         |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +        +              +  +  +        +  A           +  +  A         |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +        +              +  +  +        +  A           +  +  A         |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +        +              +  +  +        +  A           +  +  A         |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +        +              +  +  +        +  +           +  +  +         |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +        +              +  +  +        +  A           +  +  +         |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +        +              +  +  +        +  A           +  +  +         |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +        +              +  +  +        +  A           +  +  +         |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +        +              +  +  +        +  A           +  +  A         |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M        +              +  +  M        M  M           +  +  +         |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  I  +  +  +  +  +  +  M  +  +  +  M  M  +  +  +  +  +  +  +  +  +|             
      Ectasia                              |                                        3                                 |             
      Craniopharyngeal Duct, Inflammation, |                                                                          |             
           Chronic Active                  |                                        3                                 |             
      Pars Distalis, Cyst                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  73                                                               
NTP Experiment-Test: 05076-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 18:14:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 0| 7| 7| 6| 7| 7| 7| 7| 7| 7| 2| 7| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 4| 9| 4| 4| 9| 4| 4| 4| 4| 1| 0| 4| 4| 4| 2| 2| 4| 4| 4| 7| 9| 4| 4| 4| 4|             
                                           | 2| 5| 3| 3| 5| 3| 3| 4| 4| 8| 4| 1| 4| 4| 9| 7| 5| 5| 5| 7| 0| 0| 6| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    333 PPM                                | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
      0-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pars Distalis, Hyperplasia           |                         2                                                |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Vacuolization       |                                                                          |             
          Cytoplasmic                      | 3  3  3  3  3  3  2  3  3  2  3     3  3  3     2  2  3  3  2  3  3  3  3|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +        +              +  +  +        +  A           +  +  +         |             
      Inflammation, Acute                  | 2                                                                        |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                                     +                                +   |             
      Inflammation, Chronic Active         |                                     3                                3   |             
      Duct, Dilatation                     |                                     3                                4   |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +        +              +  +  +        +  A           +  +  +         |             
      Inflammation, Chronic Active         |                                  3                                       |             
      Inflammation, Suppurative            | 2           2                                                            |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +                                                                        |             
      Dilatation                           | 3                                                                        |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +        +              +  +  +        +  +           +  +  +         |             
      Seminiferous Tubule, Degeneration    |             2                                               3            |             
      Seminiferous Tubule, Mineralization  |                                                                2         |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +        +              +  +  +        +  A           +  +  +         |             
      Femoral, Hyperplasia, Neutrophil     |                               3                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +        +              +  +  +        M  +           +  +  +         |             
      Mandibular, Hyperplasia, Lymphoid    |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                                              +                           |             
      Hematopoietic Cell Proliferation     |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +        +  +           +  +  +     +  +  A           +  +  A         |             
      Hematopoietic Cell Proliferation     |             2  2              3        3                                 |             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  M        +              +  M  M        M  M           +  +  +         |             
      Depletion Lymphoid                   |             3                                                            |             
      Necrosis, Diffuse                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |                                           M                              |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +        +           +  +  +  +     +  +  +           +  +  +         |             
      Acanthosis                           |                         2  3                                             |             
      Parasite External                    |                         X  X  X           X                              |             
      Ulcer                                |                         2  2                                             |             
      Prepuce, Inflammation, Acute         | 3                                                                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  74                                                               
NTP Experiment-Test: 05076-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 18:14:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 0| 7| 7| 6| 7| 7| 7| 7| 7| 7| 2| 7| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 4| 9| 4| 4| 9| 4| 4| 4| 4| 1| 0| 4| 4| 4| 2| 2| 4| 4| 4| 7| 9| 4| 4| 4| 4|             
                                           | 2| 5| 3| 3| 5| 3| 3| 4| 4| 8| 4| 1| 4| 4| 9| 7| 5| 5| 5| 7| 0| 0| 6| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    333 PPM                                | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
      0-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Prepuce, Subcutaneous Tissue,        |                                                                          |             
          Foreign Body                     | 4                                                                        |             
      Subcutaneous Tissue, Fibrosis        |                                                                3         |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic Active                  |                                                                          |             
      Subcutaneous Tissue, Sebaceous Gland,|                                                                          |             
           Hyperplasia                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +        +  +     +  +  +  +  +        +  +  +  +     +  +  +  +  +  +|             
      Tarsal, Hyperostosis                 |                X     X  X  X  X                 X  X     X        X  X  X|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +        +              +  +  +        +  +           +  +  +         |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Peribronchiolar, Inflammation,       |                                                                          |             
          Chronic Active                   |                3  1        4     2  2  2  1     1              2        2|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +        +              +  +  +        +  +           +  +  +         |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +        +              +  +  +        +  A           +  +  +         |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                               +                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +        +              +  +  +     +  +  +           +  +  +         |             
      Nephropathy, Chronic                 |             1                                               1            |             
      Pelvis, Inflammation, Suppurative    |                                  3                                       |             
                                            __________________________________________________________________________|             
   Urethra                                 |                                  +                                       |             
      Inflammation, Chronic Active         |                                  3                                       |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +        +              +  +  +        +  A           +  +  A         |             
      Dilatation                           | 3  3                                                                     |             
      Inflammation, Chronic Active         |                                  3                                       |             
      Mucosa, Hyperplasia                  |                                  3                                       |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  75                                                               
NTP Experiment-Test: 05076-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 18:14:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 6| 6| 6| 7| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 4| 5| 3| 5| 5| 5| 5| 5| 9| 5| 5| 5| 5| 5| 5| 2| 6| 2| 0| 5| 1| 5| 4| 5| 5|            |
                                           | 6| 0| 4| 0| 0| 0| 1| 1| 0| 1| 1| 2| 2| 2| 2| 3| 2| 2| 2| 3| 9| 3| 3| 3| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    333 PPM                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|      L     |
      0-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |       +                 +                    +  +  +  +     +     +      |  18        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |       A                 +                    M  +  +  A     +     +      |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |       +                 +                    +  +  +  +     +     +      |  17        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |       +                 +                    +  +  +  +     +     +      |  17        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |       +                 +                    +  +  +  +     +     +      |  17        |
      Parasite Metazoan                    |                                                                   X      |      3     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |       +                 +                    +  +  +  +     +     +      |  17        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |       +                 +                    +  +  +  +     +     +     +|  19        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |       +                 +                    +  +  +  +     +     +      |  16        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |       +                 +                    +  +  +  +     +     +      |  16        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |       +                 +                    +  +  +  +     +     +     +|  18        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     |       X                       X     X                                    |      5     |
      Clear Cell Focus                     |                   X                                                      |      3     |
      Eosinophilic Focus                   |                   X        X  X           X                              |      8     |
      Hematopoietic Cell Proliferation     |                                                                          |      1  4.0|
      Infarct                              |                3        4        2  3                 4           3      |      7  3.1|
      Inflammation, Chronic Active         |                                                    3                     |      1  3.0|
      Bile Duct, Hyperplasia               |                                              2     2                     |      2  2.0|
      Central Vein, Thrombosis             |                                                                X         |      1     |
      Centrilobular, Cytomegaly            | 2  2  2  2  2     2  2  2  2  2  2  2  2  2        2     2     2     2  2|     36  2.0|
      Centrilobular, Necrosis, Acute       |                                              2                           |      2  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                |       +                 +                    +  +  +  +     +     +      |  17        |
      Acinus, Inflammation, Chronic Active |                                                                          |      1  3.0|
      Duct, Cyst                           |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |       +                 +                    +  +  +  +     +     +      |  19        |
                                            __________________________________________________________________________|____________|
   Stomach                                 |       +                 +                    +  +  +  +     +     +      |  17        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |       +                 +                    +  +  +  +     +     +      |  17        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |       +                 +                    +  +  +  +     +     +      |  17        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |       +                 +                    +  +  +  +     +     +      |  19        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |       +                 +                    +  +  +  +     +     +      |  18        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |       +                 +                    +  +  +  +     +     +      |  18        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |       +                 +                    +  +  +  +     +     +      |  18        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |       +                 +                    +  +  +  +     +     +      |  17        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |       +                 +                    M  +  +  +     +     +      |  14        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  76                                                               
NTP Experiment-Test: 05076-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 18:14:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 6| 6| 6| 7| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 4| 5| 3| 5| 5| 5| 5| 5| 9| 5| 5| 5| 5| 5| 5| 2| 6| 2| 0| 5| 1| 5| 4| 5| 5|            |
                                           | 6| 0| 4| 0| 0| 0| 1| 1| 0| 1| 1| 2| 2| 2| 2| 3| 2| 2| 2| 3| 9| 3| 3| 3| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    333 PPM                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|      L     |
      0-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  I  +  M  +  +  +  +|  42        |
      Ectasia                              |                                                                          |      1  3.0|
      Craniopharyngeal Duct, Inflammation, |                                                                          |            |
           Chronic Active                  |                                                                          |      1  3.0|
      Pars Distalis, Cyst                  |                            X                                             |      1     |
      Pars Distalis, Hyperplasia           |       1                                                                  |      2  1.5|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Follicular Cell, Vacuolization       |                                                                          |            |
          Cytoplasmic                      | 2  3  2  3  3  3  3  3  2  2  3     2  2  2  2  3     3  3  3  3  2  3  3|     46  2.7|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              |       +                 +                    +  +  +  +     +     +      |  18        |
      Inflammation, Acute                  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                                                                          |   2        |
      Inflammation, Chronic Active         |                                                                          |      2  3.0|
      Duct, Dilatation                     |                                                                          |      2  3.5|
                                            __________________________________________________________________________|____________|
   Prostate                                |       +                 +                    +  +  +  +     +     +      |  18        |
      Inflammation, Chronic Active         |       1                                                                  |      2  2.0|
      Inflammation, Suppurative            |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |                                                                          |   1        |
      Dilatation                           |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Testes                                  |       +              +  +                    +  +  +  +     +     +      |  20        |
      Seminiferous Tubule, Degeneration    |                                                                          |      2  2.5|
      Seminiferous Tubule, Mineralization  |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |       +                 +                    +  +  +  +     +     +      |  18        |
      Femoral, Hyperplasia, Neutrophil     |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |       +  +     +     +  +                    +  +  +  +     +     +     +|  22        |
      Mandibular, Hyperplasia, Lymphoid    |                                              2                          3|      2  2.5|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |          +     +                                +                        |   4        |
      Hematopoietic Cell Proliferation     |          2     3                                                         |      2  2.5|
                                            __________________________________________________________________________|____________|
   Spleen                                  |       +        +     +  +                    +  +  +  +     +     +      |  21        |
      Hematopoietic Cell Proliferation     |                                                                          |      4  2.5|
      Hyperplasia, Lymphoid                |                4                                                         |      1  4.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  |       +                 +                    +  +  +  +     M     M      |  11        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  77                                                               
NTP Experiment-Test: 05076-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 18:14:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 6| 6| 6| 7| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 4| 5| 3| 5| 5| 5| 5| 5| 9| 5| 5| 5| 5| 5| 5| 2| 6| 2| 0| 5| 1| 5| 4| 5| 5|            |
                                           | 6| 0| 4| 0| 0| 0| 1| 1| 0| 1| 1| 2| 2| 2| 2| 3| 2| 2| 2| 3| 9| 3| 3| 3| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    333 PPM                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|      L     |
      0-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Depletion Lymphoid                   |                                                                          |      1  3.0|
      Necrosis, Diffuse                    |                                                       2                  |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Skin                                    |       +                 +                    +  +  +  +     +  +  +  +   |  23        |
      Acanthosis                           |                                                    3           3         |      4  2.8|
      Parasite External                    |                                                                X         |      5     |
      Ulcer                                |                                                                2         |      3  2.0|
      Prepuce, Inflammation, Acute         |                                                                          |      1  3.0|
      Prepuce, Subcutaneous Tissue,        |                                                                          |            |
          Foreign Body                     |                                                                          |      1  4.0|
      Subcutaneous Tissue, Fibrosis        |                                                                2         |      2  2.5|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Chronic Active                  |                                                    3                     |      1  3.0|
      Subcutaneous Tissue, Sebaceous Gland,|                                                                          |            |
           Hyperplasia                     |                                                                2         |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +   |  42        |
      Tarsal, Hyperostosis                 | X  X     X     X  X  X     X  X  X  X  X  X        X  X  X     X     X   |     28     |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |       +                 +                    +  +  +  +     +     +      |  19        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Alveolar Epithelium, Hyperplasia     |                                           1     3                        |      2  2.0|
      Peribronchiolar, Inflammation,       |                                                                          |            |
          Chronic Active                   |          2     1  2  2                                      2     2     3|     17  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    |       +                 +                    +  +  +  +     +     +      |  19        |
                                            __________________________________________________________________________|____________|
   Trachea                                 |       +                 +                    +  +  +  +     +     +      |  18        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                   +     +|   3        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |       +        +        +                    +  +  +  +     +     +      |  21        |
      Nephropathy, Chronic                 |       1                                                                  |      3  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  78                                                               
NTP Experiment-Test: 05076-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 18:14:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 6| 6| 6| 6| 7| 6| 7| 7| 7| 7|            |
                             DAY ON TEST   | 4| 5| 3| 5| 5| 5| 5| 5| 9| 5| 5| 5| 5| 5| 5| 2| 6| 2| 0| 5| 1| 5| 4| 5| 5|            |
                                           | 6| 0| 4| 0| 0| 0| 1| 1| 0| 1| 1| 2| 2| 2| 2| 3| 2| 2| 2| 3| 9| 3| 3| 3| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|      A     |
    333 PPM                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|      L     |
      0-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Pelvis, Inflammation, Suppurative    |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Urethra                                 |                                                                          |   1        |
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |       +                 +                    +  +  +  +     +     +      |  17        |
      Dilatation                           |                                                                          |      2  3.0|
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
      Mucosa, Hyperplasia                  |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  79                                                               
NTP Experiment-Test: 05076-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 18:14:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 3| 0| 0| 0| 1| 0| 7| 7| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 4| 4| 4| 4| 1| 2| 1| 1| 2| 0| 0| 4| 8| 4| 7| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                                           | 3| 3| 3| 3| 1| 5| 4| 3| 4| 8| 4| 4| 1| 4| 6| 4| 4| 9| 5| 5| 5| 5| 6| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    333 PPM                                | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
      3-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |             +  +  M  M  +  M  +     +     +        +                     |             
                                            __________________________________________________________________________|             
   Gallbladder                             |             +  +  M  M  +  M  +     A     A        +                     |             
                                            __________________________________________________________________________|             
   Intestine Large                         |             +  +  +  +  +  M  +     +     +        +                     |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |             +  +  M  M  +  M  +     +     A        +                     |             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |             +  +  A  +  +  M  +     +     +        +                     |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |             +  +  M  +  +  M  +     +     M        +                     |             
      Parasite Metazoan                    |                      X                                                   |             
                                            __________________________________________________________________________|             
   Intestine Small                         |             +  +  +  M  +  M  +     +     +        +                     |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |             +  +  M  M  +  M  +     +     +        +                     |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |             +  +  M  M  +  M  +     +     A        +                     |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |             +  +  A  M  +  M  +     +     +        +                     |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  M  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                        X  X                              |             
      Clear Cell Focus                     |                                                                          |             
      Eosinophilic Focus                   |                                     X                                X   |             
      Hematopoietic Cell Proliferation     |                                                                      2   |             
      Infarct                              |                                                    4                     |             
      Centrilobular, Cytomegaly            | 2  2  2                       2  2  1  2     2  2     2     2  2  2  2  2|             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |             +  +  M  M  +  M  +     +     +        +                     |             
      Inflammation, Chronic Active         |                                                                          |             
      Acinus, Atrophy                      |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |             +  +  M  M  +  M  +     +     +        +                     |             
                                            __________________________________________________________________________|             
   Stomach                                 |             +  +  M  M  +  M  +     +     +        +                     |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |             +  +  M  M  +  M  +     +     +        +                     |             
      Acanthosis                           |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |             +  +  M  M  +  M  +     +     +        +                     |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |             +  +  M  M  +  M  +     +     +        +                     |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |             +  +  M  M  +  M  +     +     +        +                     |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |             +  +  M  M  +  M  +     +     +        +                     |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |             +  +  M  M  +  M  +     +     +        +                     |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |             +  +  M  M  +  M  +     +     +        +                     |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |             +  M  M  M  +  M  +     +     +        +                     |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  M  +  +  M  M  +  M  I  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |                                                                      X   |             
      Pars Distalis, Hyperplasia           |    2                                                                     |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  M  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Hyperplasia         |                                  2     2                 3               |             
      Follicular Cell, Vacuolization       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  80                                                               
NTP Experiment-Test: 05076-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 18:14:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 3| 0| 0| 0| 1| 0| 7| 7| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 4| 4| 4| 4| 1| 2| 1| 1| 2| 0| 0| 4| 8| 4| 7| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                                           | 3| 3| 3| 3| 1| 5| 4| 3| 4| 8| 4| 4| 1| 4| 6| 4| 4| 9| 5| 5| 5| 5| 6| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    333 PPM                                | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
      3-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
          Cytoplasmic                      | 2  2  3  2  1                 2  2  2     2  3  3  2  2     3  2  2  3  2|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |             +  +  M  M  +  M  +     +     +        +                     |             
                                            __________________________________________________________________________|             
   Penis                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                                                             +            |             
      Inflammation, Chronic Active         |                                                                          |             
      Duct, Dilatation                     |                                                             3            |             
                                            __________________________________________________________________________|             
   Prostate                                |             +  +  M  M  +  M  +     +     +        +                     |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |                                                                          |             
      Dilatation                           |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  |             +  +  M  M     M  +     +     +        +                     |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |             +  +  +  I  +  I  +     A     +                              |             
                                            __________________________________________________________________________|             
   Lymph Node                              |             +  +  M  M  +  M  +     +     +        +        +        +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                                                             +        +  +|             
      Hematopoietic Cell Proliferation     |                                                                         2|             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  |          +  +  +  M  M  +  M  +  +  +     +     +  +     +  +        +   |             
      Depletion Lymphoid                   |                2                                                         |             
      Hematopoietic Cell Proliferation     |                                           4     3                    3   |             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  |             +  +  M  M  +  M  +     +     M        M                     |             
      Depletion Lymphoid                   |                3        3                                                |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |                                                    M                     |             
                                            __________________________________________________________________________|             
   Skin                                    |             +  +  M  M  +  M  +  +  +     +  +  +  +     +  +        +   |             
      Acanthosis                           |                                  3  2                                2   |             
      Parasite External                    |             X                    X  X                                X   |             
      Ulcer                                |                                                                      2   |             
      Subcutaneous Tissue, Fibrosis        |                                                                      2   |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic Active                  |                3                                                         |             
      Subcutaneous Tissue, Metaplasia,     |                                                                          |             
           Osseous                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |             +  +  +  +  +  I  +  +  +  +  +     +  +  +  +  +  +  +     +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  81                                                               
NTP Experiment-Test: 05076-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 18:14:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 3| 0| 0| 0| 1| 0| 7| 7| 6| 7| 6| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 4| 4| 4| 4| 1| 2| 1| 1| 2| 0| 0| 4| 8| 4| 7| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                                           | 3| 3| 3| 3| 1| 5| 4| 3| 4| 8| 4| 4| 1| 4| 6| 4| 4| 9| 5| 5| 5| 5| 6| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    333 PPM                                | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
      3-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
      Tarsal, Hyperostosis                 |                               X  X     X  X     X  X  X  X  X  X  X     X|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |             +  +  M  M  +  M  +     +     +        +                     |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  M  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic, Diffuse       |                                                                          |             
      Alveolar Epithelium, Hyperplasia     | 1                                            1                           |             
      Alveolus, Hyperplasia, Macrophage    |                                                                          |             
      Peribronchial, Inflammation, Chronic |                                                                          |             
          Active                           |                                                                          |             
      Peribronchiolar, Inflammation,       |                                                                          |             
          Chronic Active                   | 2     2  2  2  2                             1        1  1     3  2  1   |             
      Perivascular, Inflammation, Chronic  |                                                                          |             
          Active                           |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |             +  +  M  +  +  M  +     +     +        +                     |             
                                            __________________________________________________________________________|             
   Trachea                                 |             +  +  M  M  +  M  +     +     +        +                     |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |             +  +  M  M  +  M  +     +     +        +                 +   |             
      Cortex, Cyst                         |                                                                      X   |             
      Cortex, Infiltration Cellular, Focal,|                                                                          |             
           Histiocyte                      |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |             +  +  M  M  +  M  +     +     +        +                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  82                                                               
NTP Experiment-Test: 05076-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 18:14:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 6| 6| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 5| 7|            |
                             DAY ON TEST   | 9| 4| 5| 6| 2| 5| 7| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 9| 5| 5| 5| 8| 1|            |
                                           | 0| 6| 1| 6| 6| 0| 7| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 3| 5| 3| 3| 3| 4| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    333 PPM                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|      L     |
      3-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +     +  +  +     +                                      +           +  +|  15        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +     +  +  +     +                                      +           +  +|  13        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +     +  +  +     +                                      +           +  +|  17        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +     +  +  +     +                                      +           +  +|  14        |
      Inflammation, Acute                  |          2                                                               |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +     +  +  +     +                                      +           +  +|  16        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +     +  +  +     +                                      +           +  +|  15        |
      Parasite Metazoan                    |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +     +  +  +     +                                      +  +        +  +|  17        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +     +  +  +     +                                      +           +  +|  15        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +     +  +  +     +                                      +           +  +|  14        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +     +  +  +     +                                      +  +        +  +|  16        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Basophilic Focus                     |                                              X     X                     |      4     |
      Clear Cell Focus                     |                            X                                             |      1     |
      Eosinophilic Focus                   |                                                                X         |      3     |
      Hematopoietic Cell Proliferation     | 2                 3                                                      |      3  2.3|
      Infarct                              |          2              4                                                |      3  3.3|
      Centrilobular, Cytomegaly            | 1  2  2     2  2     2     2  2  2  2  2  2  2     2  2     2     2     1|     33  1.9|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                      +   |   1        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +     +  +  +     +                                      +           +  +|  15        |
      Inflammation, Chronic Active         |                   2                                                      |      1  2.0|
      Acinus, Atrophy                      |                   2                                                      |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +     +  +  +     +                                      +           +  +|  15        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +     +  +  +     +                 +                    +           +  +|  16        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +     +  +  +     +                 +                    +           +  +|  16        |
      Acanthosis                           |                                     3                                    |      1  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +     +  +  +     +                                      +           +  +|  15        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +     +  +  +     +                                      +           +  +|  15        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +     +  +  +     +                                      +           +  +|  15        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +     +  +  +     +                                      +           +  +|  15        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +     +  +  +     +                                      +           +  +|  15        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +     +  +  +     +                                      +           +  +|  15        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +     M  +  +     +                                      M           +  +|  12        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  I  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +|  41        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  83                                                               
NTP Experiment-Test: 05076-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 18:14:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 6| 6| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 5| 7|            |
                             DAY ON TEST   | 9| 4| 5| 6| 2| 5| 7| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 9| 5| 5| 5| 8| 1|            |
                                           | 0| 6| 1| 6| 6| 0| 7| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 3| 5| 3| 3| 3| 4| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    333 PPM                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|      L     |
      3-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Pars Distalis, Cyst                  |                                                                          |      1     |
      Pars Distalis, Hyperplasia           |                                                    2                     |      2  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Follicular Cell, Hyperplasia         |                                                                          |      3  2.3|
      Follicular Cell, Vacuolization       |                                                                          |            |
          Cytoplasmic                      | 2  3  2  2  2  3  2  3  3  3  3  3  3  3  3  3  3  3  2  3  2  3  3  1  3|     43  2.5|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +     +  +  +     +                                      +           +  +|  15        |
                                            __________________________________________________________________________|____________|
   Penis                                   | +                                                                        |   1        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +     +                                +                                 |   4        |
      Inflammation, Chronic Active         | 3     3                                                                  |      2  3.0|
      Duct, Dilatation                     |       3                                                                  |      2  3.0|
                                            __________________________________________________________________________|____________|
   Prostate                                | +     +  +  +     +                                      +           +  +|  15        |
      Inflammation, Chronic Active         |             4                                                            |      1  4.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |             +                                                            |   1        |
      Dilatation                           |             2                                                            |      1  2.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +     +  +  +     +                                      +           +  +|  14        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +     +  +  +     +                                      +           +  I|  13        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +     +  +  +     +                             +        +  +        +  +|  20        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +                 +                             +        M  +        +   |   8        |
      Hematopoietic Cell Proliferation     | 3                                               2                        |      3  2.3|
      Inflammation, Chronic Active         |                                                                      3   |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +     +  +  +     +                       +  +  +        +           +  +|  24        |
      Depletion Lymphoid                   |             2                                                            |      2  2.0|
      Hematopoietic Cell Proliferation     |                                                 3        3               |      5  3.2|
      Hyperplasia, Lymphoid                |                                              3                           |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +     +  M  +     +                                      +           +  M|  11        |
      Depletion Lymphoid                   |                                                                          |      2  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +                                                                        |   1        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +     +  +  +     +                    +     +  +        +  +        +  +|  25        |
      Acanthosis                           |                                                                          |      3  2.3|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  84                                                               
NTP Experiment-Test: 05076-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 18:14:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 6| 6| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 5| 7|            |
                             DAY ON TEST   | 9| 4| 5| 6| 2| 5| 7| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 9| 5| 5| 5| 8| 1|            |
                                           | 0| 6| 1| 6| 6| 0| 7| 0| 0| 0| 1| 1| 1| 1| 2| 2| 2| 2| 3| 5| 3| 3| 3| 4| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|      A     |
    333 PPM                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|      L     |
      3-3                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Parasite External                    |                                                                          |      4     |
      Ulcer                                |          3                                      3           2           3|      5  2.6|
      Subcutaneous Tissue, Fibrosis        |                                                                          |      1  2.0|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Chronic Active                  |          3                                                               |      2  3.0|
      Subcutaneous Tissue, Metaplasia,     |                                                                          |            |
           Osseous                         |                                                             2            |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +     I  +  +  +  +  +     +  +  +  +     +  +  +|  39        |
      Tarsal, Hyperostosis                 |    X  X        X  X  X  X        X  X  X  X  X     X  X     X     X  X  X|     29     |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +     +  +  +     +                                      +           +  +|  15        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Inflammation, Chronic, Diffuse       |                   3                                                      |      1  3.0|
      Alveolar Epithelium, Hyperplasia     |             2  1                                                  1      |      5  1.2|
      Alveolus, Hyperplasia, Macrophage    |                      3                                                   |      1  3.0|
      Peribronchial, Inflammation, Chronic |                                                                          |            |
          Active                           |                                                    1              1      |      2  1.0|
      Peribronchiolar, Inflammation,       |                                                                          |            |
          Chronic Active                   | 1        1                       2              2                    2   |     16  1.7|
      Perivascular, Inflammation, Chronic  |                                                                          |            |
          Active                           |                      3        2                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Nose                                    | +     +  +  +     +                                      +           +  +|  16        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +     +  +  +     +                                      +           +  +|  15        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                         +                                                |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +     +                                      +           +  +|  17        |
      Cortex, Cyst                         |                                                                          |      1     |
      Cortex, Infiltration Cellular, Focal,|                                                                          |            |
           Histiocyte                      |    3                                                                     |      1  3.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +     +  +  +     +                                      +           +  +|  15        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  85                                                               
NTP Experiment-Test: 05076-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 18:14:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 5| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 7| 4| 0| 3| 4| 4| 1| 4| 4| 4| 4| 4| 4| 4| 4| 5| 3| 4| 3| 4| 4| 4| 4| 5| 9|             
                                           | 6| 3| 5| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 8| 6| 5| 5| 6| 6| 6| 6| 0| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    333 PPM                                | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
      10-3                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +     +  +        +                          +  +     +                 +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | A     +  M        M                          A  +     +                 A|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +     +  +        +                 +        A  +     +                 +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | A     +  +        +                 +        A  +     A                 +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +     +  +        +                          A  +     +                 +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +     +  +        +                          A  +     +                 +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +        +                          A  +     +                 +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | A     +  +        +                          A  +     +                 +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | A     +  +        +                          A  +     A                 +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +        +                          A  +     +                 +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                                          X               |             
      Clear Cell Focus                     |                                           X        X     X           X   |             
      Eosinophilic Focus                   |                                     X     X        X                     |             
      Fibrosis                             |                            2                                             |             
      Hematopoietic Cell Proliferation     |                            4                                             |             
      Infarct                              |                                                                         2|             
      Mixed Cell Focus                     |                                                                          |             
      Bile Duct, Cyst                      |                                                                          |             
      Central Vein, Thrombosis             |                                                                          |             
      Centrilobular, Cytomegaly            |    2  1     2  2  1  2  2        2  2  2  3        2  1  2     2     2   |             
      Centrilobular, Necrosis              | 2                                                                        |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +     +  +        +                          +  +     +                 +|             
      Acinus, Inflammation, Chronic Active |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +     +  +        +                          +  +     +                 +|             
                                            __________________________________________________________________________|             
   Stomach                                 | A     +  +        +                          +  +     +  +     +        +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | A     +  +        +                          +  +     +  +     +        +|             
      Acanthosis                           |                                                                          |             
      Cyst Epithelial Inclusion            |                                                                          |             
      Ulcer                                |                                                          2               |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | A     +  +        +                          +  +     +                 +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +     +  +        +                          +  +     +                 +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +     +  +        +                          +  +     +                 I|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +     +  +        +                          +  +     +                 I|             
      Hyperplasia                          |                   3                                                      |             
      Hypertrophy                          |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +     +  +        +                          +  +     +                 I|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  86                                                               
NTP Experiment-Test: 05076-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 18:14:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 5| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 7| 4| 0| 3| 4| 4| 1| 4| 4| 4| 4| 4| 4| 4| 4| 5| 3| 4| 3| 4| 4| 4| 4| 5| 9|             
                                           | 6| 3| 5| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 8| 6| 5| 5| 6| 6| 6| 6| 0| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    333 PPM                                | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
      10-3                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +     +  +        +                          +  +     +                 +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +     +  +        +                          +  +     +                 M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Pars Distalis, Hyperplasia           |                                                    2                     |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Artery, Inflammation, Chronic Active |                                                                          |             
      Follicular Cell, Hyperplasia         |                                           2                 2            |             
      Follicular Cell, Vacuolization       |                                                                          |             
          Cytoplasmic                      | 3  3  2  3  3  2  2  3  3  2  3  3  3  3  3  1  2  3  2  2  3  3  3  2  2|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +     +  +        +                          +  +     +                 +|             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |             +           +                                                |             
      Inflammation, Chronic Active         |             3                                                            |             
      Duct, Dilatation                     |             4           4                                                |             
                                            __________________________________________________________________________|             
   Prostate                                | +     +  +        +                          +  +     +                 +|             
      Inflammation, Chronic Active         |                                                       2                  |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |                   +                                                      |             
      Dilatation                           |                   2                                                      |             
                                            __________________________________________________________________________|             
   Testes                                  | +     +  +        +                          +  +     +                 +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +     +  +        +                          +  +     +                 +|             
      Femoral, Hyperplasia, Neutrophil     |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +        +           +     +        +  +  +  +        +        M|             
      Mandibular, Hyperplasia, Lymphoid    |                                     2                                    |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |    +                          A              +     +           +         |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +        +                          +  +     +        +        +|             
      Hematopoietic Cell Proliferation     | 3                                               3              3        4|             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | M     +  +        +                          +  +     +                 M|             
      Depletion Lymphoid                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +     +  +     +  +  +     +           +     +  +     +                 +|             
      Acanthosis                           |                                        2                                 |             
      Parasite External                    |                      X                 X                                 |             
      Ulcer                                |                      3                 2                                 |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  87                                                               
NTP Experiment-Test: 05076-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 18:14:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 5| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 5| 7| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 7| 4| 0| 3| 4| 4| 1| 4| 4| 4| 4| 4| 4| 4| 4| 5| 3| 4| 3| 4| 4| 4| 4| 5| 9|             
                                           | 6| 3| 5| 2| 3| 3| 3| 3| 4| 4| 4| 4| 5| 5| 5| 8| 6| 5| 5| 6| 6| 6| 6| 0| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    333 PPM                                | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
      10-3                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Subcutaneous Tissue, Fibrosis        |                4                                                         |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |       +  +        +     +        +        +  +  +  +  +  +  +  +        +|             
      Tarsal, Hyperostosis                 |                         X        X        X  X  X  X     X  X  X         |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +     +  +        +                          +  +     +                 +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar Epithelium, Hyperplasia     |                                        2  2                              |             
      Alveolus, Hyperplasia, Macrophage    |                                                                          |             
      Peribronchial, Inflammation, Chronic |                                                                          |             
          Active                           |                                                                          |             
      Peribronchiolar, Inflammation,       |                                                                          |             
          Chronic Active                   |                                  1                                   1   |             
      Perivascular, Inflammation, Chronic  |                                                                          |             
          Active                           |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +     +  +        +                          +  +     +                 A|             
      Mucosa, Inflammation, Acute          |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +     +  +        +                          +  +     +                 +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +     +  +        +                          +  +     +                 +|             
      Nephropathy, Chronic                 |       1                                                                  |             
      Renal Tubule, Mineralization         |                                                       2                  |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | A     +  +        +                          A  +     +                 +|             
      Dilatation                           |                                                       4                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  88                                                               
NTP Experiment-Test: 05076-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 18:14:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 3| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 3| 7| 7| 7| 5| 7|            |
                             DAY ON TEST   | 4| 2| 7| 1| 5| 5| 5| 7| 2| 5| 5| 0| 5| 5| 5| 6| 5| 5| 6| 9| 5| 5| 5| 6| 4|            |
                                           | 0| 4| 3| 1| 0| 1| 1| 4| 8| 1| 1| 7| 2| 2| 2| 3| 2| 2| 9| 5| 3| 3| 3| 2| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|      A     |
    333 PPM                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|      L     |
      10-3                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +              +  +        +           +        +  +           +  +|  19        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | A  +  +              A  +        +           +        +  +           A  +|  11        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +              A  +        +           +        +  +           +  +|  18        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | A  +  +              A  +        +           +        +  A           A  +|  13        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +              A  +        +           +        +  M           +  +|  16        |
      Parasite Metazoan                    |    X                                                                     |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | M  +  +              A  +        +           +        +  +           +  +|  16        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +              A  +        +           +  +     +  +           +  +|  19        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +              A  +        +           +        +  A           A  +|  14        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +              A  +        +           +        +  A           A  +|  13        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +              A  +        +           +        +  +           +  +|  18        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Basophilic Focus                     |                X     X                                                   |      3     |
      Clear Cell Focus                     |                   X                                                      |      5     |
      Eosinophilic Focus                   |                                                                          |      3     |
      Fibrosis                             |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     |                         3        3                                      2|      4  3.0|
      Infarct                              |                4                                                         |      2  3.0|
      Mixed Cell Focus                     |                               X                                   X      |      2     |
      Bile Duct, Cyst                      |    X                                                              X      |      2     |
      Central Vein, Thrombosis             |                                                    X                     |      1     |
      Centrilobular, Cytomegaly            | 2     3     2              2  2           2  1  2  2  2     2     2     2|     29  1.9|
      Centrilobular, Necrosis              |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                              +                           |   1        |
      Inflammation, Chronic Active         |                                              3                           |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +              A  +        +           +        +  A           +  +|  17        |
      Acinus, Inflammation, Chronic Active |                                              4                           |      1  4.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +              +  M        M           +        +  +           +  +|  17        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +              A  +     +  +     +     +        +  +  +        +  +|  22        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +              A  +     +  +     +     +        +  +  +        +  +|  22        |
      Acanthosis                           |                               3                                          |      1  3.0|
      Cyst Epithelial Inclusion            |                                                             X            |      1     |
      Ulcer                                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +              A  +        +           +        +  +  +        +  +|  18        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +              +  +        +           +        +  +           +  +|  19        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  89                                                               
NTP Experiment-Test: 05076-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 18:14:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 3| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 3| 7| 7| 7| 5| 7|            |
                             DAY ON TEST   | 4| 2| 7| 1| 5| 5| 5| 7| 2| 5| 5| 0| 5| 5| 5| 6| 5| 5| 6| 9| 5| 5| 5| 6| 4|            |
                                           | 0| 4| 3| 1| 0| 1| 1| 4| 8| 1| 1| 7| 2| 2| 2| 3| 2| 2| 9| 5| 3| 3| 3| 2| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|      A     |
    333 PPM                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|      L     |
      10-3                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +              +  +        +           +        +  +           +  +|  18        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +              +  +        +           +        +  +           +  +|  18        |
      Hyperplasia                          |                                                                          |      1  3.0|
      Hypertrophy                          |                                                                      2   |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +              +  +        +           +        +  +           +  +|  18        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +              A  +        +           +        +  A           +  +|  17        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +              +  +        M           +        M  +           +  +|  16        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|  45        |
      Pars Distalis, Hyperplasia           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|  48        |
      Artery, Inflammation, Chronic Active |                                                          3               |      1  3.0|
      Follicular Cell, Hyperplasia         |                   2        2  2        2                          2      |      7  2.0|
      Follicular Cell, Vacuolization       |                                                                          |            |
          Cytoplasmic                      | 3     1     3  3  3  3  2  3  2  2  3  3  3  2  3  3     1  2     2  1  3|     46  2.5|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +              +  +        +           +        +  +           +  +|  19        |
      Inflammation, Chronic Active         | 4                       2                                                |      2  3.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                                        +                                 |   3        |
      Inflammation, Chronic Active         |                                        4                                 |      2  3.5|
      Duct, Dilatation                     |                                                                          |      2  4.0|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +              +  +        +           +        +  +           +  +|  19        |
      Inflammation, Chronic Active         | 2                                                        2               |      3  2.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |                                                                          |   1        |
      Dilatation                           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +              +  +        +           +        +  +           +  +|  19        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +              +  +        +           +        +  +           +  +|  19        |
      Femoral, Hyperplasia, Neutrophil     |                      3  3                                                |      2  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +              +  M        +           +        +  +           +  +|  22        |
      Mandibular, Hyperplasia, Lymphoid    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +     +                                                                  |   6        |
      Hemorrhage                           |       4                                                                  |      1  4.0|
      Inflammation, Chronic Active         | 2                                                                        |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +              +  +        +     +  +  +        +  +  +        +  +|  24        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  90                                                               
NTP Experiment-Test: 05076-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 18:14:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 3| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 3| 7| 7| 7| 5| 7|            |
                             DAY ON TEST   | 4| 2| 7| 1| 5| 5| 5| 7| 2| 5| 5| 0| 5| 5| 5| 6| 5| 5| 6| 9| 5| 5| 5| 6| 4|            |
                                           | 0| 4| 3| 1| 0| 1| 1| 4| 8| 1| 1| 7| 2| 2| 2| 3| 2| 2| 9| 5| 3| 3| 3| 2| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|      A     |
    333 PPM                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|      L     |
      10-3                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Hematopoietic Cell Proliferation     |                      4  3        4                                      3|      8  3.4|
      Hyperplasia, Lymphoid                |                                           3                              |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  M  +              A  +        M           +        +  M           M  +|  11        |
      Depletion Lymphoid                   |       3                                                                  |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +              +  +        +  +  +     +        +  +        +  +  +|  26        |
      Acanthosis                           | 2                                                                        |      2  2.0|
      Parasite External                    | X  X                                         X                           |      5     |
      Ulcer                                |                                        2                                 |      3  2.3|
      Subcutaneous Tissue, Fibrosis        |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  38        |
      Tarsal, Hyperostosis                 | X  X  X     X  X  X  X  X  X  X     X  X  X  X  X  X     X  X  X  X      |     29     |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +              +  +        +           +        +  +           +  +|  19        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Alveolar Epithelium, Hyperplasia     |                                                                         1|      3  1.7|
      Alveolus, Hyperplasia, Macrophage    |       4                                                                  |      1  4.0|
      Peribronchial, Inflammation, Chronic |                                                                          |            |
          Active                           |                                                    1                     |      1  1.0|
      Peribronchiolar, Inflammation,       |                                                                          |            |
          Chronic Active                   | 2  2        1  1                       2                                 |      7  1.4|
      Perivascular, Inflammation, Chronic  |                                                                          |            |
          Active                           |                                           2                              |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +              +  +        +           +        +  +           +  +|  18        |
      Mucosa, Inflammation, Acute          |                                                                      3   |      1  3.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +              +  +        +           +        +  +           +  +|  19        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                   +              +                    +                  |   3        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +              +  +        +           +        +  +           +  +|  19        |
      Nephropathy, Chronic                 |                                                       1                  |      2  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  91                                                               
NTP Experiment-Test: 05076-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 18:14:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 5| 3| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 6| 3| 7| 7| 7| 5| 7|            |
                             DAY ON TEST   | 4| 2| 7| 1| 5| 5| 5| 7| 2| 5| 5| 0| 5| 5| 5| 6| 5| 5| 6| 9| 5| 5| 5| 6| 4|            |
                                           | 0| 4| 3| 1| 0| 1| 1| 4| 8| 1| 1| 7| 2| 2| 2| 3| 2| 2| 9| 5| 3| 3| 3| 2| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|      A     |
    333 PPM                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|      L     |
      10-3                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Renal Tubule, Mineralization         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +              A  +        +           +        +  +           +  +|  16        |
      Dilatation                           |                                                          4               |      2  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  92                                                               
NTP Experiment-Test: 05076-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 18:14:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 6| 5| 6| 0| 2| 1| 6| 7| 7| 7| 7| 7| 7| 7| 2| 7| 7| 7| 6| 6| 6| 6|             
                             DAY ON TEST   | 4| 7| 8| 3| 2| 6| 0| 4| 9| 7| 4| 4| 4| 2| 4| 4| 4| 2| 4| 4| 4| 9| 7| 7| 5|             
                                           | 3| 1| 8| 6| 5| 9| 3| 1| 9| 1| 3| 4| 4| 6| 4| 5| 5| 6| 5| 6| 6| 4| 2| 2| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    1000 PPM                               | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
       0-10                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  M  M  +  +  +  A  +  A  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  A  +  +  +  A  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute, Necrotizing     |                                                                          |             
      Parasite Metazoan                    |       X                                                           X  X   |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  M|             
      Parasite Metazoan                    |    X                                            X                        |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  A|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  A  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  M|             
      Inflammation, Chronic Active         |       4                                                                  |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Eosinophilic Focus                   | X                                                                        |             
      Hematopoietic Cell Proliferation     |                                                                3         |             
      Infarct                              | 2        4  3  1           2     2     3     2        2  2  1  2  2  2  3|             
      Centrilobular, Cytomegaly            | 1        2  1  1     2  2  1  1     2     2     1  1  2  1           1   |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                        +              +                  |             
      Angiectasis                          |                                                       2                  |             
      Inflammation, Acute, Necrotizing     |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |    4                                   4              1                  |             
      Perivascular, Inflammation, Chronic  |                                                                          |             
          Active                           |                                                       2                  |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |                                                                          |             
      Perivascular, Inflammation,          |                                                                          |             
          Suppurative                      |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                                                          |             
      Inflammation, Acute                  |                                  2                                       |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dysplasia                            |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                            +                                             |             
      Incisor, Upper, Dysplasia            |                                                                          |             
      Peridontal Tissue, Inflammation,     |                                                                          |             
           Suppurative                     |                            2                                             |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  93                                                               
NTP Experiment-Test: 05076-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 18:14:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 6| 5| 6| 0| 2| 1| 6| 7| 7| 7| 7| 7| 7| 7| 2| 7| 7| 7| 6| 6| 6| 6|             
                             DAY ON TEST   | 4| 7| 8| 3| 2| 6| 0| 4| 9| 7| 4| 4| 4| 2| 4| 4| 4| 2| 4| 4| 4| 9| 7| 7| 5|             
                                           | 3| 1| 8| 6| 5| 9| 3| 1| 9| 1| 3| 4| 4| 6| 4| 5| 5| 6| 5| 6| 6| 4| 2| 2| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    1000 PPM                               | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
       0-10                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bacterium, Acute, Multiple           |                                                                          |             
      Artery, Inflammation, Chronic Active |                                                       2                  |             
      Valve, Inflammation, Suppurative     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 2        2                                                               |             
      Hypertrophy                          |                2                 2  1     1        1     3  1            |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                           2                              |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  +  M  M  +  M  +  +  +  M  M  +  M  M  M  M  M  +  M  M  M  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  M  +  +  I  +  +  +  I  +  I  +  +  +  +  +  +  M  +  +|             
      Pars Distalis, Hyperplasia           | 3  3  2  3  2  3              2  3  2     2     2     2  2  2  2     2   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Hyperplasia         | 3  3  3  3  2  4           2  2  3  2  4  3  3  3     4  3  3  3  1  3   |             
      Follicular Cell, Vacuolization       |                                                                          |             
          Cytoplasmic                      | 2  4  3  3  3  2     3  4  3  4  2  3  3  4  3  2  4  3  4  3  3  4  3  4|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Arteriole, Inflammation, Chronic     |                                                                          |             
          Active                           |                                     1                                    |             
                                            __________________________________________________________________________|             
   Penis                                   |                +                                                         |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                +                                                         |             
      Inflammation, Chronic Active         |                2                                                         |             
      Inflammation, Suppurative            |                                                                          |             
      Duct, Dilatation                     |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                   1      |             
      Arteriole, Inflammation, Chronic     |                                                                          |             
          Active                           |                                     1                                    |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |                         +                                +               |             
      Dilatation                           |                         2                                                |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Arteriole, Inflammation, Chronic     |                                                                          |             
          Active                           |                                     1                                    |             
      Seminiferous Tubule, Degeneration    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  94                                                               
NTP Experiment-Test: 05076-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 18:14:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 6| 5| 6| 0| 2| 1| 6| 7| 7| 7| 7| 7| 7| 7| 2| 7| 7| 7| 6| 6| 6| 6|             
                             DAY ON TEST   | 4| 7| 8| 3| 2| 6| 0| 4| 9| 7| 4| 4| 4| 2| 4| 4| 4| 2| 4| 4| 4| 9| 7| 7| 5|             
                                           | 3| 1| 8| 6| 5| 9| 3| 1| 9| 1| 3| 4| 4| 6| 4| 5| 5| 6| 5| 6| 6| 4| 2| 2| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    1000 PPM                               | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
       0-10                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Femoral, Hyperplasia, Neutrophil     |             4                                                            |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                +           +                          +  +  +            |             
      Hematopoietic Cell Proliferation     |                                                       3  2  2            |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |             3                                                            |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  M  +  M  +  +  M  +  +  M  +  M  +  M  M  +  M  +  M  M  M  +  M  +  M|             
      Necrosis, Diffuse                    |                      3  3                                                |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite External                    |          X     X           X  X     X        X  X     X  X  X  X  X  X  X|             
      Subcutaneous Tissue, Edema           |                                                                          |             
      Subcutaneous Tissue, Fibrosis        |                                                                          |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic Active                  |                                        1                          1  1   |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Tarsal, Hyperostosis                 |                                  X        X     X           X     X  X   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infarct                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic, Diffuse       |                                  3                                       |             
      Alveolar Epithelium, Hyperplasia     |    2                                                        3            |             
      Alveolus, Hyperplasia, Macrophage    |                                                                          |             
      Arteriole, Capillary, Inflammation,  |                                                                          |             
           Suppurative                     |                                                                          |             
      Artery, Mediastinum, Inflammation,   |                                                                          |             
           Suppurative                     |                                                                          |             
      Peribronchiolar, Inflammation, Acute,|                                                                          |             
           Necrotizing                     |                   4                                                      |             
      Peribronchiolar, Inflammation,       |                                                                          |             
          Chronic Active                   |                            2  2           2     1     1     2  3     1  1|             
      Perivascular, Inflammation, Chronic  |                                                                          |             
          Active                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  95                                                               
NTP Experiment-Test: 05076-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 18:14:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 6| 5| 6| 0| 2| 1| 6| 7| 7| 7| 7| 7| 7| 7| 2| 7| 7| 7| 6| 6| 6| 6|             
                             DAY ON TEST   | 4| 7| 8| 3| 2| 6| 0| 4| 9| 7| 4| 4| 4| 2| 4| 4| 4| 2| 4| 4| 4| 9| 7| 7| 5|             
                                           | 3| 1| 8| 6| 5| 9| 3| 1| 9| 1| 3| 4| 4| 6| 4| 5| 5| 6| 5| 6| 6| 4| 2| 2| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    1000 PPM                               | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
       0-10                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mucosa, Inflammation, Acute          |                                  1                                       |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                  +                                       |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                +  +      |             
      Atrophy                              |                                                                4  2      |             
      Inflammation                         |                                                                          |             
      Inflammation, Suppurative            |                                                                   3      |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                            +  +        +        +     +     +  +  +  +   |             
      Inflammation, Chronic Active         |                            4                    2              4  4  3   |             
      Inflammation, Suppurative            |                                        4              2     4            |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy, Chronic                 |    2           1           1  1           1  1  1     1  1  1  1     1   |             
      Pelvis, Inflammation, Suppurative    |                                                    2                     |             
      Renal Tubule, Necrosis               |                      2                                                   |             
                                            __________________________________________________________________________|             
   Urethra                                 |                      +  +                          +                     |             
      Inflammation, Suppurative            |                      3  1                          2                     |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                    3                     |             
      Arteriole, Inflammation, Chronic     |                                                                          |             
          Active                           |                                     1                                    |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  96                                                               
NTP Experiment-Test: 05076-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 18:14:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 5| 6| 7| 6| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 1| 4| 5| 5| 1| 2| 5| 5| 9| 5| 0| 7| 3| 1| 9| 5| 5| 5| 8| 8| 5| 2| 5| 5| 5|            |
                                           | 0| 6| 0| 0| 8| 3| 0| 1| 0| 0| 0| 6| 6| 5| 4| 1| 2| 2| 2| 9| 2| 7| 3| 3| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|      A     |
    1000 PPM                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|      L     |
       0-10                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | A  M  M  +  +  +  +  +  +  A  M  +  M  +  A  +  +  +  +  A  M  +  M  +  +|  33        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  A  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  42        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Acute, Necrotizing     |                            4                                             |      1  4.0|
      Parasite Metazoan                    | X                          X                       X              X  X   |      8     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Parasite Metazoan                    |                            X                                      X      |      4     |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | M  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  A  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  43        |
      Parasite Metazoan                    |                      X                             X              X  X   |      4     |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  44        |
      Inflammation, Chronic Active         |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Eosinophilic Focus                   |                                                    X                     |      2     |
      Hematopoietic Cell Proliferation     |                                                                          |      1  3.0|
      Infarct                              | 3  2  1  2  3           4     4  2  3     3  4  1     3  3  3  1  2  4   |     33  2.5|
      Centrilobular, Cytomegaly            |    1                             2  2  2  1  1     1           2  1  1   |     25  1.4|
                                            __________________________________________________________________________|____________|
   Mesentery                               |             +              +                             +               |   5        |
      Angiectasis                          |                                                                          |      1  2.0|
      Inflammation, Acute, Necrotizing     |                            3                                             |      1  3.0|
      Inflammation, Chronic Active         |             2                                                            |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  A  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  45        |
      Acinus, Atrophy                      |       1                                                                  |      4  2.5|
      Perivascular, Inflammation, Chronic  |                                                                          |            |
          Active                           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acinus, Atrophy                      |    2                                                                     |      1  2.0|
      Perivascular, Inflammation,          |                                                                          |            |
          Suppurative                      |                3                                                         |      1  3.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Acanthosis                           |                                              2                           |      1  2.0|
      Inflammation, Acute                  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  48        |
      Dysplasia                            |       2                                                                  |      1  2.0|
      Inflammation, Chronic                |    2                                2                                    |      2  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  97                                                               
NTP Experiment-Test: 05076-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 18:14:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 5| 6| 7| 6| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 1| 4| 5| 5| 1| 2| 5| 5| 9| 5| 0| 7| 3| 1| 9| 5| 5| 5| 8| 8| 5| 2| 5| 5| 5|            |
                                           | 0| 6| 0| 0| 8| 3| 0| 1| 0| 0| 0| 6| 6| 5| 4| 1| 2| 2| 2| 9| 2| 7| 3| 3| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|      A     |
    1000 PPM                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|      L     |
       0-10                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                          +           +  +|   4        |
      Incisor, Upper, Dysplasia            |                                                                      1   |      1  1.0|
      Peridontal Tissue, Inflammation,     |                                                                          |            |
           Suppurative                     |                                                                         2|      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Bacterium, Acute, Multiple           |                1                                                         |      1  1.0|
      Artery, Inflammation, Chronic Active |                                                                          |      1  2.0|
      Valve, Inflammation, Suppurative     |                1                                                         |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                  1                                       |      3  1.7|
      Hypertrophy                          |                                              2  3                       1|     10  1.7|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                             1            |      2  1.5|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  A  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  M  +  M  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  M  +|  30        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  A  M  +  +  +  +  +  +  +  +  M  M  +  +  +  +|  41        |
      Pars Distalis, Hyperplasia           | 2     2  2  2  2  2  2  3        1  2  2     2  2     2              2  2|     32  2.2|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Follicular Cell, Hyperplasia         | 3  2  2  3  1  2  2  2  2  2  3  2  2  3  2  2  2     2  2  4  3  3  2  2|     44  2.5|
      Follicular Cell, Vacuolization       |                                                                          |            |
          Cytoplasmic                      | 3  2  3  3  3  4  3     4  3  3  4  3  3  2  3  4  4  4  3  2     3  3  4|     47  3.2|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Arteriole, Inflammation, Chronic     |                                                                          |            |
          Active                           |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Penis                                   |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                                                          +               |   2        |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Inflammation, Suppurative            |                                                          3               |      1  3.0|
      Duct, Dilatation                     |                                                          3               |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  98                                                               
NTP Experiment-Test: 05076-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 18:14:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 5| 6| 7| 6| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 1| 4| 5| 5| 1| 2| 5| 5| 9| 5| 0| 7| 3| 1| 9| 5| 5| 5| 8| 8| 5| 2| 5| 5| 5|            |
                                           | 0| 6| 0| 0| 8| 3| 0| 1| 0| 0| 0| 6| 6| 5| 4| 1| 2| 2| 2| 9| 2| 7| 3| 3| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|      A     |
    1000 PPM                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|      L     |
       0-10                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +     +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Inflammation, Suppurative            |                                                                          |      1  1.0|
      Arteriole, Inflammation, Chronic     |                                                                          |            |
          Active                           |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |                                                                          |   2        |
      Dilatation                           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Arteriole, Inflammation, Chronic     |                                                                          |            |
          Active                           |                                                                          |      1  1.0|
      Seminiferous Tubule, Degeneration    |                                     2                                    |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                          +               |   1        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Femoral, Hyperplasia, Neutrophil     |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                                              +        +                  |   7        |
      Hematopoietic Cell Proliferation     |                                                                          |      3  2.3|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hematopoietic Cell Proliferation     |             3                                         2                  |      3  2.7|
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  M  M  +  M  M  +  M  I  M  +  M  I  M  M  M  I  M  M  M  +  +  M  M  M|  16        |
      Necrosis, Diffuse                    |                                                                          |      2  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|  49        |
      Parasite External                    |    X     X     X  X     X     X        X     X  X  X        X     X  X  X|     28     |
      Subcutaneous Tissue, Edema           |                                  4                                       |      1  4.0|
      Subcutaneous Tissue, Fibrosis        |                                  3                                       |      1  3.0|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Chronic Active                  |                      1                       1                           |      5  1.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Tarsal, Hyperostosis                 |       X  X        X                             X  X        X  X  X  X   |     15     |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Infarct                              |                                                          3               |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  99                                                               
NTP Experiment-Test: 05076-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 18:14:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 6| 7| 7| 5| 6| 7| 6| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7|            |
                             DAY ON TEST   | 1| 4| 5| 5| 1| 2| 5| 5| 9| 5| 0| 7| 3| 1| 9| 5| 5| 5| 8| 8| 5| 2| 5| 5| 5|            |
                                           | 0| 6| 0| 0| 8| 3| 0| 1| 0| 0| 0| 6| 6| 5| 4| 1| 2| 2| 2| 9| 2| 7| 3| 3| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|      A     |
    1000 PPM                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|      L     |
       0-10                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic, Diffuse       |                                                                          |      1  3.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      2  2.5|
      Alveolus, Hyperplasia, Macrophage    |                                                    2                     |      1  2.0|
      Arteriole, Capillary, Inflammation,  |                                                                          |            |
           Suppurative                     |                4                                                         |      1  4.0|
      Artery, Mediastinum, Inflammation,   |                                                                          |            |
           Suppurative                     |                4                                                         |      1  4.0|
      Peribronchiolar, Inflammation, Acute,|                                                                          |            |
           Necrotizing                     |                                                                          |      1  4.0|
      Peribronchiolar, Inflammation,       |                                                                          |            |
          Chronic Active                   | 2     2  1              1  1        2     2                 3  2  2  3  1|     21  1.8|
      Perivascular, Inflammation, Chronic  |                                                                          |            |
          Active                           |                                                    2                     |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mucosa, Inflammation, Acute          |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Eye                                     | +  +                 +                                      +            |   6        |
      Atrophy                              | 4                    4                                      2            |      5  3.2|
      Inflammation                         |    4                                                                     |      1  4.0|
      Inflammation, Suppurative            |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |    +        +  +           +     +  +                       +  +     +   |  18        |
      Inflammation, Chronic Active         |    4           4                 3  1                                1   |     10  3.0|
      Inflammation, Suppurative            |             3              4                                             |      5  3.4|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Nephropathy, Chronic                 |    1  1  1  1        1  2                                   2     2  1  1|     22  1.2|
      Pelvis, Inflammation, Suppurative    |                                                                          |      1  2.0|
      Renal Tubule, Necrosis               |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urethra                                 |                                                                          |   3        |
      Inflammation, Suppurative            |                                                                          |      3  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
      Arteriole, Inflammation, Chronic     |                                                                          |            |
          Active                           |                                                                          |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 100                                                               
NTP Experiment-Test: 05076-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 18:14:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 4| 7| 7| 6| 2| 6| 6| 7| 7| 5| 7| 7| 6| 7| 7| 5| 7| 6| 7| 7| 7| 5| 6| 7|             
                             DAY ON TEST   | 6| 4| 4| 4| 8| 6| 5| 6| 4| 4| 2| 4| 2| 8| 4| 4| 2| 1| 4| 2| 4| 4| 0| 9| 4|             
                                           | 3| 9| 3| 3| 5| 0| 8| 9| 3| 3| 9| 4| 7| 5| 4| 4| 2| 8| 1| 7| 5| 5| 7| 3| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    1000 PPM                               | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
       10-10                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  A  +  +  +  A  A  +  +  M  M  M  M  M  +  +  A  +  M  M  +  M  A  M  +|             
      Epithelium, Hypertrophy, Focal       |                                                                         2|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  A  +  +  +  A  A  +  +  +  +  +  +  A  +  +  A  +  A  +  +  +  A  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Parasite Metazoan                    |                                  X                    X  X     X         |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  A  +  +  +  A  A  +  +  +  M  +  +  +  +  +  A  +  A  +  +  +  A  +  +|             
      Parasite Metazoan                    |                                                                X         |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  A  +  +  +  A  +  +  +  +  +  +  +  A  +  +  A  +  A  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  A  +  +  +  A  +  +  +  +  +  +  +  A  +  +  A  +  A  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  A  +  +  +  A  M  +  +  +  +  M  +  A  +  +  A  +  A  +  +  +  A  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  A  +  +  +  A  A  +  +  +  +  +  +  A  +  +  A  +  A  +  +  +  A  +  +|             
      Lymphatic, Ectasia                   |                                                    2                     |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                                                   X      |             
      Eosinophilic Focus                   | X           X              X              X  X              X     X     X|             
      Infarct                              |          2  3           3  3  3     3  3     2     2  3     2  4  4  2   |             
      Centrilobular, Cytomegaly            | 3  3     2  3        2     2  2  2  2  2  2  2     2  3  2  2  2  2     2|             
      Oval Cell, Hyperplasia               |                         3                 3                              |             
                                            __________________________________________________________________________|             
   Mesentery                               |                   +                             +  +                     |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Acinus, Atrophy                      |                                                                         2|             
      Duct, Ectasia                        |                            1                                             |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  A  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  A  +  +  +  A  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Infiltration Cellular, Mast Cell     |                                                                         2|             
      Inflammation, Acute                  |                                           1                              |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Peridontal Tissue, Inflammation,     |                                                                          |             
           Suppurative                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Chronic                |                         3                                                |             
      Mineralization                       |                   2                                                      |             
      Thrombosis                           |                   X                                                      |             
      Valve, Bacterium                     |                                                 3                        |             
      Valve, Inflammation, Suppurative     |                                                 2                        |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 101                                                               
NTP Experiment-Test: 05076-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 18:14:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 4| 7| 7| 6| 2| 6| 6| 7| 7| 5| 7| 7| 6| 7| 7| 5| 7| 6| 7| 7| 7| 5| 6| 7|             
                             DAY ON TEST   | 6| 4| 4| 4| 8| 6| 5| 6| 4| 4| 2| 4| 2| 8| 4| 4| 2| 1| 4| 2| 4| 4| 0| 9| 4|             
                                           | 3| 9| 3| 3| 5| 0| 8| 9| 3| 3| 9| 4| 7| 5| 4| 4| 2| 8| 1| 7| 5| 5| 7| 3| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    1000 PPM                               | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
       10-10                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    1                                   1                                 |             
      Hypertrophy                          |             1                             2                              |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                         2        1                                       |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  A  +  +  M  +  M  +  +  M  +  +  +  +  +  +  M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  I  +  M  +  A  +  M  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Pars Distalis, Hyperplasia           | 2     2     3     1        2     2  3  1  3  2     2     2  2  2         |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Hyperplasia         | 3  2  4  3  3     2  4     3  2  2  4  3  3  3  1  3  2  3  2  2  4  4  2|             
      Follicular Cell, Vacuolization       |                                                                          |             
          Cytoplasmic                      | 3  2  2  2  2     2  3     3  2  3  2  2  2  3  3  3  3  2  3  3  3  3  3|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Penis                                   | +                                                                        |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +                                                                        |             
      Duct, Dilatation                     | 2                                                                        |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Seminiferous Tubule, Degeneration    |                         3                                                |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  A  +  +  +  +  +  +  +  A  +  +  A  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Lumbar, Necrosis                     |                   3                                                      |             
      Pancreatic, Necrosis                 |                   3                                                      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                   +                             +  +                     |             
      Hematopoietic Cell Proliferation     |                   2                                                      |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Hematopoietic Cell Proliferation     |                                        3                                 |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  M  +  M  A  M  M  M  M  +  +  M  M  M  M  M  M  M  +  M  M  M  M  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 102                                                               
NTP Experiment-Test: 05076-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 18:14:58  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 4| 7| 7| 6| 2| 6| 6| 7| 7| 5| 7| 7| 6| 7| 7| 5| 7| 6| 7| 7| 7| 5| 6| 7|             
                             DAY ON TEST   | 6| 4| 4| 4| 8| 6| 5| 6| 4| 4| 2| 4| 2| 8| 4| 4| 2| 1| 4| 2| 4| 4| 0| 9| 4|             
                                           | 3| 9| 3| 3| 5| 0| 8| 9| 3| 3| 9| 4| 7| 5| 4| 4| 2| 8| 1| 7| 5| 5| 7| 3| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    1000 PPM                               | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
       10-10                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Parasite External                    |                                                             X  X         |             
      Subcutaneous Tissue, Fibrosis        |                      2                                                   |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Tarsal, Hyperostosis                 |          X  X                    X  X     X  X     X     X              X|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Alveolar Epithelium, Hyperplasia     |                                                    1              3      |             
      Peribronchiolar, Inflammation,       |                                                                          |             
          Chronic Active                   | 1  1     2        3  3  2           1                                    |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mucosa, Inflammation, Acute          |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                      +  +                                                |             
      Atrophy                              |                      4  4                                                |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                      +  +                          +     +               |             
      Inflammation, Chronic Active         |                      3  2                                                |             
      Inflammation, Suppurative            |                                                    4                     |             
      Necrosis                             |                         4                                                |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infarct                              |                                           2                              |             
      Nephropathy, Chronic                 | 1     1  1                 1  2  1  1                       1        1  1|             
      Renal Tubule, Necrosis               |                                                                   3      |             
                                            __________________________________________________________________________|             
   Urethra                                 |    +                                                                     |             
      Inflammation, Suppurative            |    3                                                                     |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page 103                                                               
NTP Experiment-Test: 05076-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 18:14:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 6| 7| 6| 6| 6| 5| 7| 2| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5|            |
                             DAY ON TEST   | 4| 4| 4| 5| 5| 8| 5| 9| 9| 9| 5| 5| 9| 9| 0| 5| 5| 5| 5| 5| 3| 5| 4| 5| 9|            |
                                           | 6| 6| 6| 0| 0| 5| 0| 7| 4| 7| 7| 1| 5| 7| 1| 1| 1| 2| 2| 2| 7| 3| 9| 3| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|      A     |
    1000 PPM                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|      L     |
       10-10                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  M  +  +  +  +  +  +  M  M  A  M  M  +  +  +  +  A  +  M  +  M|  27        |
      Epithelium, Hypertrophy, Focal       |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  A  +  +|  40        |
      Parasite Metazoan                    |                            X                 X                 X         |      3     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +|  45        |
      Parasite Metazoan                    |       X     X     X                                         X  X         |      9     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +|  41        |
      Parasite Metazoan                    | X                 X                             X                        |      4     |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +|  42        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  A  +  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +|  41        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +|  40        |
      Parasite Metazoan                    |             X                                                            |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +  A  +  +  +  +|  40        |
      Lymphatic, Ectasia                   |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Basophilic Focus                     |                                                                          |      1     |
      Eosinophilic Focus                   |                X  X              X                                       |     11     |
      Infarct                              | 1  2  2  2  3  3  2     2     2  2        2     2  2  3  1  4  1  3  2  2|     34  2.4|
      Centrilobular, Cytomegaly            | 2  2     2  2  1  2  2  2  2  2  2        2  2  2  2  2  2  1  1     1  1|     40  2.0|
      Oval Cell, Hyperplasia               |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   3        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Acinus, Atrophy                      |                                                    2                     |      2  2.0|
      Duct, Ectasia                        |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +     +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +     +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|  44        |
      Infiltration Cellular, Mast Cell     |                                                                          |      1  2.0|
      Inflammation, Acute                  |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                            +                                             |   1        |
      Peridontal Tissue, Inflammation,     |                                                                          |            |
           Suppurative                     |                            2                                             |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Degeneration, Chronic                |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 104                                                               
NTP Experiment-Test: 05076-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 18:14:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 6| 7| 6| 6| 6| 5| 7| 2| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5|            |
                             DAY ON TEST   | 4| 4| 4| 5| 5| 8| 5| 9| 9| 9| 5| 5| 9| 9| 0| 5| 5| 5| 5| 5| 3| 5| 4| 5| 9|            |
                                           | 6| 6| 6| 0| 0| 5| 0| 7| 4| 7| 7| 1| 5| 7| 1| 1| 1| 2| 2| 2| 7| 3| 9| 3| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|      A     |
    1000 PPM                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|      L     |
       10-10                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Mineralization                       |                                                                          |      1  2.0|
      Thrombosis                           |                                                                          |      1     |
      Valve, Bacterium                     |                                                                          |      1  3.0|
      Valve, Inflammation, Suppurative     |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |                                                                         1|      3  1.0|
      Hypertrophy                          | 2              1        1                 1              2               |      7  1.4|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |       2  2                                                               |      4  1.8|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  M  +  M  M  +  +  +  +  +  +  M  +  +  +  +  M  +|  40        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  I  +  M  +  +  +  +  +  M  +  +  I  +  +  +  M  +  +  +  +  +  +  +|  39        |
      Pars Distalis, Hyperplasia           | 2  2     2        3  2           2           2  2     2  2     2         |     25  2.1|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Follicular Cell, Hyperplasia         | 3  2  2  2  4  3  4  4  4  3  3  3     1  3  4  3  3  3  3  1  2  3  3  3|     47  2.8|
      Follicular Cell, Vacuolization       |                                                                          |            |
          Cytoplasmic                      | 2  2  3  3  2  2  1  3  2  2  3  4     3  3  1  2  2  2  2  4  3  3     1|     46  2.5|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Chronic Active         |       2                                                                  |      1  2.0|
                                            __________________________________________________________________________|____________|
   Penis                                   |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                                                                          |   1        |
      Duct, Dilatation                     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Suppurative            |                                     4                                   2|      2  3.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Seminiferous Tubule, Degeneration    |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Lumbar, Necrosis                     |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 105                                                               
NTP Experiment-Test: 05076-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 18:14:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 6| 7| 6| 6| 6| 5| 7| 2| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5|            |
                             DAY ON TEST   | 4| 4| 4| 5| 5| 8| 5| 9| 9| 9| 5| 5| 9| 9| 0| 5| 5| 5| 5| 5| 3| 5| 4| 5| 9|            |
                                           | 6| 6| 6| 0| 0| 5| 0| 7| 4| 7| 7| 1| 5| 7| 1| 1| 1| 2| 2| 2| 7| 3| 9| 3| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|      A     |
    1000 PPM                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|      L     |
       10-10                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Pancreatic, Necrosis                 |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                                                             +           +|   5        |
      Hematopoietic Cell Proliferation     |                                                             2            |      2  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Hematopoietic Cell Proliferation     |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  M  +  +  I  M  M  M  M  M  M  I  M  A  M  M  M  +  +  +  +  +  I  +  M|  16        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acanthosis                           |       1                                                                  |      1  1.0|
      Parasite External                    |                         X  X     X        X                              |      6     |
      Subcutaneous Tissue, Fibrosis        |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Tarsal, Hyperostosis                 | X  X  X  X        X     X        X        X  X  X  X  X  X        X  X   |     24     |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Alveolar Epithelium, Hyperplasia     |                                  2        2                              |      4  2.0|
      Peribronchiolar, Inflammation,       |                                                                          |            |
          Chronic Active                   | 1  2  3  2  3           2  2  2  2              1                 2      |     18  1.9|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Mucosa, Inflammation, Acute          | 3                                                                        |      1  3.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +|  48        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   2        |
      Atrophy                              |                                                                          |      2  4.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |          +                 +                                             |   6        |
      Inflammation, Chronic Active         |                                                                          |      2  2.5|
      Inflammation, Suppurative            |                                                                          |      1  4.0|
      Necrosis                             |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 106                                                               
NTP Experiment-Test: 05076-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 04/29/97  
Route: DOSED FEED                                                                                                 Time: 18:14:58  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 6| 7| 6| 6| 6| 5| 7| 2| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5|            |
                             DAY ON TEST   | 4| 4| 4| 5| 5| 8| 5| 9| 9| 9| 5| 5| 9| 9| 0| 5| 5| 5| 5| 5| 3| 5| 4| 5| 9|            |
                                           | 6| 6| 6| 0| 0| 5| 0| 7| 4| 7| 7| 1| 5| 7| 1| 1| 1| 2| 2| 2| 7| 3| 9| 3| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|      A     |
    1000 PPM                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|      L     |
       10-10                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
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 URINARY SYSTEM - cont                     |