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TR 388 Mouse Pathology Tables

NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11 
LAB: Battelle Columbus                                         DATE: 09/10/94   
EXP: 05076                    ETHYLENETHIOUREA                 TIME: 02:18:36   
TEST: 02              CAGES FROM 0000 TO LAST CAGE             PAGE:   1        
TEST TYPE: CHRONIC          ROUTE: DOSED FEED                  NTP C#: 03372    
CONT: N01ES82151                                               CAS: 96-45-7     
PATHOLOGIST: R. PERSING                      S. EUSTIS                          
--------------------------------------------------------------------------------
                                                                                
                                                                                
                                                                                


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NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11
LAB: Battelle Columbus                                         DATE: 09/10/94  
EXP: 05076                    ETHYLENETHIOUREA                 TIME: 02:18:36  
TEST: 02              CAGES FROM 0000 TO LAST CAGE                             
TEST TYPE: CHRONIC          ROUTE: DOSED FEED                  NTP C#: 03372   
CONT: N01ES82151                                               CAS: 96-45-7    
PATHOLOGIST: R. PERSING                      S. EUSTIS                         

                                 ETHYLENETHIOUREA


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 743 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 0 PPM   0-0                              |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 19     CENSORED DEATHS 0    TERMINAL 31        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      20    178   184   281   283   302   311   427   520   565                 |
 |      566   618   630   656   662   666   666   672   705                       |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = 0 PPM   10-0                                   |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 17     CENSORED DEATHS 6    TERMINAL 27        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      180   234   235   279   307   309   351   351   351   368                 |
 |      578   628   663   711   716   722   735                                   |
 |  CENSORED DEATHS                                                               |
 |      51    51    51    51    51    171                                         |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = 100 PPM   1-1                                  |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 34     UNCENSORED DEATHS 7      CENSORED DEATHS 1    TERMINAL 26        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      345   424   516   532   557   593   705                                   |
 |  CENSORED DEATHS                                                               |
 |      641                                                                       |
 |                                                                                |
 ==================================================================================

                                 ETHYLENETHIOUREA


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 743 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                          DOSE = 333 PPM   0-3                                  |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 18     CENSORED DEATHS 0    TERMINAL 32        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      95    142   241   602   619   622   623   627   662   677                 |
 |      690   690   695   704   718   729   734   740                             |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = 333 PPM   3-3                                  |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 18     CENSORED DEATHS 0    TERMINAL 32        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      8     13    14    25    124   311   526   584   595   649                 |
 |      651   666   676   677   681   690   704   711                             |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = 333 PPM   10-3                                 |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 18     CENSORED DEATHS 1    TERMINAL 31        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      395   532   535   536   562   573   576   613   658   663                 |
 |      669   674   693   705   707   724   728   740                             |
 |  CENSORED DEATHS                                                               |
 |      311                                                                       |
 |                                                                                |
 ==================================================================================

                                 ETHYLENETHIOUREA


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 743 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                          DOSE = 1000 PPM   0-10                                |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 27     CENSORED DEATHS 0    TERMINAL 23        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      3     199   226   241   525   576   582   618   636   636                 |
 |      650   669   671   671   672   672   688   689   690   694                 |
 |      694   700   710   715   723   726   727                                   |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = 1000 PPM   10-10                               |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 25     CENSORED DEATHS 0    TERMINAL 25        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      260   295   297   449   507   522   529   557   597   641                 |
 |      658   663   669   685   685   685   693   694   697   697                 |
 |      701   718   727   727   737                                               |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================

                                 ETHYLENETHIOUREA


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 743 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   743 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |0 PPM   0-0|    98.0  96.0  94.0  86.0  86.0  84.0  82.0  78.0  70.0  62.0      |
 |           |                                                                    |
 |           |                                                                    |
 |0          |   100.0  97.7  93.2  79.5  77.3  77.3  77.3  75.0  70.5  61.4      |
 |PPM   10-0 |                                                                    |
 |           |                                                                    |
 |100        |   100.0 100.0 100.0  97.1  94.1  94.1  88.2  82.4  82.4  79.3      |
 |PPM   1-1  |                                                                    |
 |           |                                                                    |
 |333        |   100.0  96.0  94.0  94.0  94.0  94.0  94.0  92.0  82.0  64.0      |
 |PPM   0-3  |                                                                    |
 |           |                                                                    |
 |333        |    92.0  90.0  90.0  88.0  88.0  88.0  86.0  82.0  78.0  64.0      |
 |PPM   3-3  |                                                                    |
 |           |                                                                    |
 |333        |   100.0 100.0 100.0 100.0  98.0  98.0  91.8  85.7  79.6  63.3      |
 |PPM   10-3 |                                                                    |
 |           |                                                                    |
 |1000       |    98.0  98.0  92.0  92.0  92.0  92.0  90.0  86.0  78.0  46.0      |
 |PPM   0-10 |                                                                    |
 |           |                                                                    |
 |1000       |   100.0 100.0  98.0  94.0  94.0  92.0  86.0  82.0  76.0  50.0      |
 |PPM   10-10|                                                                    |
 |           |                                                                    |
 ==================================================================================

                                 ETHYLENETHIOUREA


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 743 DAYS


 ===============================================================================================================================
 |                                               SURVIVAL SUMMARY STATISTICS                                                   |
 |                                                                                                                             |
 |                                                                                                                             |
 |-----------------------------------------------------------------------------------------------------------------------------|
 |                                                                        DOSE                                                 |
 |                                                                                                                             |
 |                                0 PPM   0-0 0           100         333         333         333         1000        1000     |
 |                                            PPM   10-0  PPM   1-1   PPM   0-3   PPM   3-3   PPM   10-3  PPM   0-10  PPM   10-|0
 |-----------------------------------------------------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       62.0%       61.4%       79.3%       64.0%       64.0%       63.3%       46.0%       50.0%    |
 |(KAPLAN-MEIER)          |                                                                                                    |
 |                        |                                                                                                    |
 |SIGNIFICANCE (B)        |       P=0.022      -----      P=0.148N    P=0.726N    P=0.894N    P=0.757N    P=0.353     P=0.553  |
 |(LIFE TABLE)            |                                                                                                    |
 |                        |                                                                                                    |
 |MEAN DAY OF             |       469.1       454.0       524.6       589.4       461.4       626.8       592.7       603.6    |
 |NATURAL DEATHS (C)      |       (48.6)      (49.2)      (43.9)      (48.1)      (67.6)      (21.8)      (36.7)      (28.6)   |
 |(STANDARD ERROR)        |                                                                                                    |
 |                        |                                                                                                    |
 |MEAN LIFE SPAN (D)      |       638.9       564.1       695.0       687.7       641.6       692.5       661.8       673.3    |
 |(STANDARD ERROR)        |       (26.3)      (36.1)      (17.6)      (20.0)      (30.7)      (13.5)      (22.4)      (17.3)   |
 |                        |                                                                                                    |
 ===============================================================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                                 ETHYLENETHIOUREA


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 740 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 0 PPM   0-0                              |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 15     CENSORED DEATHS 0    TERMINAL 35        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      327   411   487   499   499   624   648   665   667   667                 |
 |      670   698   701   705   714                                               |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = 0 PPM   10-0                                   |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 12     CENSORED DEATHS 0    TERMINAL 38        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      491   523   540   555   587   609   611   642   698   712                 |
 |      725   737                                                                 |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = 100 PPM   1-1                                  |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 29     UNCENSORED DEATHS 8      CENSORED DEATHS 0    TERMINAL 21        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      359   529   552   562   612   655   668   705                             |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================

                                 ETHYLENETHIOUREA


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 740 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                          DOSE = 333 PPM   0-3                                  |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 7      CENSORED DEATHS 0    TERMINAL 43        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      503   529   569   667   667   668   674                                   |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = 333 PPM   3-3                                  |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 14     CENSORED DEATHS 0    TERMINAL 36        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      605   621   647   648   648   660   663   677   680   688                 |
 |      688   698   706   709                                                     |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = 333 PPM   10-3                                 |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 14     CENSORED DEATHS 0    TERMINAL 36        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      440   619   625   650   653   653   665   698   701   710                 |
 |      734   738   738   738                                                     |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================

                                 ETHYLENETHIOUREA


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 740 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                          DOSE = 1000 PPM   0-10                                |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 19     CENSORED DEATHS 0    TERMINAL 31        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      13    499   539   611   614   619   653   657   663   663                 |
 |      674   691   691   691   697   698   726   733   735                       |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = 1000 PPM   10-10                               |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 21     CENSORED DEATHS 0    TERMINAL 29        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      275   443   457   542   570   579   598   640   642   663                 |
 |      677   678   680   683   697   697   701   709   709   712                 |
 |      733                                                                       |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================

                                 ETHYLENETHIOUREA


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 740 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   740 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |0 PPM   0-0|   100.0 100.0 100.0  98.0  96.0  96.0  90.0  90.0  84.0  70.0      |
 |           |                                                                    |
 |           |                                                                    |
 |0          |   100.0 100.0 100.0 100.0 100.0 100.0  94.0  90.0  84.0  76.0      |
 |PPM   10-0 |                                                                    |
 |           |                                                                    |
 |100        |   100.0 100.0 100.0  96.6  96.6  96.6  93.1  86.2  79.3  72.4      |
 |PPM   1-1  |                                                                    |
 |           |                                                                    |
 |333        |   100.0 100.0 100.0 100.0 100.0 100.0  96.0  94.0  94.0  86.0      |
 |PPM   0-3  |                                                                    |
 |           |                                                                    |
 |333        |   100.0 100.0 100.0 100.0 100.0 100.0 100.0  98.0  86.0  72.0      |
 |PPM   3-3  |                                                                    |
 |           |                                                                    |
 |333        |   100.0 100.0 100.0 100.0 100.0  98.0  98.0  98.0  86.0  72.0      |
 |PPM   10-3 |                                                                    |
 |           |                                                                    |
 |1000       |    98.0  98.0  98.0  98.0  98.0  98.0  94.0  94.0  80.0  62.0      |
 |PPM   0-10 |                                                                    |
 |           |                                                                    |
 |1000       |   100.0 100.0 100.0  98.0  98.0  94.0  92.0  86.0  80.0  58.0      |
 |PPM   10-10|                                                                    |
 |           |                                                                    |
 ==================================================================================

                                 ETHYLENETHIOUREA


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 740 DAYS


 ===============================================================================================================================
 |                                               SURVIVAL SUMMARY STATISTICS                                                   |
 |                                                                                                                             |
 |                                                                                                                             |
 |-----------------------------------------------------------------------------------------------------------------------------|
 |                                                                        DOSE                                                 |
 |                                                                                                                             |
 |                                0 PPM   0-0 0           100         333         333         333         1000        1000     |
 |                                            PPM   10-0  PPM   1-1   PPM   0-3   PPM   3-3   PPM   10-3  PPM   0-10  PPM   10-|0
 |-----------------------------------------------------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       70.0%       76.0%       72.4%       86.0%       72.0%       72.0%       62.0%       58.0%    |
 |(KAPLAN-MEIER)          |                                                                                                    |
 |                        |                                                                                                    |
 |SIGNIFICANCE (B)        |       P=0.026      -----      P=1.000N    P=0.087N    P=0.904N    P=0.849N    P=0.566     P=0.327  |
 |(LIFE TABLE)            |                                                                                                    |
 |                        |                                                                                                    |
 |MEAN DAY OF             |       598.8       619.2       580.3       611.0       667.0       668.7       624.6       623.1    |
 |NATURAL DEATHS (C)      |       (31.5)      (24.3)      (38.4)      (28.3)      ( 8.3)      (20.9)      (36.8)      (24.9)   |
 |(STANDARD ERROR)        |                                                                                                    |
 |                        |                                                                                                    |
 |MEAN LIFE SPAN (D)      |       697.6       711.0       695.9       721.9       719.6       720.0       696.1       690.9    |
 |(STANDARD ERROR)        |       (13.1)      ( 9.3)      (16.8)      ( 7.4)      ( 5.2)      ( 7.3)      (15.9)      (13.2)   |
 |                        |                                                                                                    |
 ===============================================================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                                                          ETHYLENETHIOUREA
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        0 PPM   0-0      = 1
                                                        0 PPM   10-0     = 2
                                                        100 PPM   1-1    = 3
                                                        333 PPM   0-3    = 4
                                                        333 PPM   3-3    = 5
                                                        333 PPM   10-3   = 6
                                                        1000 PPM   0-10  = 7
                                                        1000 PPM   10-10 = 8

------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

           |
           |
       100 +  1751          4           2           8           3      6
           |   7 1          4      4    1  7    2   8    8      3      6   3              6
           |    5 5                4    11 7   7 4     1 8                 3   8        3 66        4
           |      5             5               27    2                        8       8 7 6   6    4  4
     P  90 +                    5                     21  15                           8373    667
     E     |                                              11     2                       83   3 667
     R     |                                               1               1             15   3  6538 6447   4
     C     |                                                                             1     1   38 6   8564 4   3
     E  80 +                                                     2 2                                     7878664 4 3     3
     N     |                                                       2                           1 2     1   58856
     T     |                                                                                     2     11   18558444
           |                                                                                            2   11 556 4 4
     S  70 +                                                                                                 11 55 62464
     U     |                                                                                                  7 85 522
     R     |                                                                                                  1  881522444
     V     |                                                                                                     771  2261
     I  60 +                                                                                                      88
     V     |                                                                                                       8 8
     A     |                                                                                                      7 778
     L     |                                                                                                         77 8
        50 +                                                                                                            88
           |
           |                                                                                                          7  7
           |
        40 +
           |
           ---+---------+---------+---------+---------+---------+---------+---------+---------+---------+---------+---------+--
              0        10        20        30        40        50        60        70        80        90        100       110

                                                                   WEEK

NOTE: 61 obs hidden.

                                                          ETHYLENETHIOUREA
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        0 PPM   0-0      = 1
                                                        0 PPM   10-0     = 2
                                                        100 PPM   1-1    = 3
                                                        333 PPM   0-3    = 4
                                                        333 PPM   3-3    = 5
                                                        333 PPM   10-3   = 6
                                                        1000 PPM   0-10  = 7
                                                        1000 PPM   10-10 = 8

----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
  100 + 1 7                                         8       1    3           6        24                5
      |
      |   7                                         8       1            1   68       24   24           5 5
      |                                                          3       1    8  8   1 7   2372   4       56  5
   95 +
      |                                                                          8   1 1     72 2 4      7 6  6   4
      |                                                                                     3 832 8 2         66
      |
   90 +                                                                                1       3 3882   2771  5  5
      |
P     |                                                                                            8   82271  16 644
E     |                                                                                          3     8 2   21  1 4  6      4
R  85 +
C     |                                                                                                      2 7 1155 26
E     |                                                                                                  3   8 3 8  55262
N     |
T  80 +                                                                                                          7 7    2 2 6
      |                                                                                                        3  3
S     |                                                                                                           17 51   2 62
U     |                                                                                                           388 11     2
R  75 +
V     |                                                                                                                55
I     |                                                                                                             87711    3
V     |
A  70 +                                                                                                                 1    1
L     |
      |                                                                                                               78  7
      |                                                                                                                88 7 7
   65 +
      |
      |                                                                                                                     77
      |
   60 +                                                                                                                 8   8
      |
      |                                                                                                                     88
      |
   55 +
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 36 obs hidden.

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