National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/2427

TR 388 Rat Pathology Tables


                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                          ETHYLENETHIOUREA


NTP Experiment-Test: 05076-01                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 09/09/94
Route: DOSED FEED                                                                                                 Time: 20:34:58




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  96-45-7

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05076-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 09/09/94  
Route: DOSED FEED                                                                                                 Time: 20:34:58  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0 PPM        0 PPM        25 PPM       83 PPM       83 PPM       83 PPM          
                                                   0-0          10-0         1-1           0-3          3-3          10-3           
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          50           50           50           50           50           50           
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                20           15           13            8           10           13           
    Natural Death                                      6            5            3            9           13            4           
  Survivors                                                                                                                         
    Moribund Sacrifice                                                                        2            1                        
    Terminal Sacrifice                                23           30           34           30           26           32           
    Natural Death                                      1                                      1                         1           
  Animals Examined Microscopically                    50           50           50           50           50           50           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (50)         (50)         (49)         (50)         (49)         (50)         
      Foreign Body                                                                                                      1 (2%)      
   Intestine Large, Cecum                             (46)         (46)         (48)         (42)         (39)         (46)         
      Artery, Necrosis, Fibrinoid                                                1 (2%)                                             
      Perivascular, Inflammation, Chronic Active                                 1 (2%)                                             
   Intestine Large, Colon                             (47)         (47)         (50)         (45)         (43)         (47)         
      Parasite Metazoan                                             1 (2%)                    1 (2%)       1 (2%)       1 (2%)      
   Intestine Large, Rectum                            (48)         (46)         (49)         (43)         (41)         (47)         
      Parasite Metazoan                                2 (4%)       6 (13%)      4 (8%)       2 (5%)       7 (17%)      4 (9%)      
   Intestine Small, Duodenum                          (49)         (49)         (50)         (48)         (48)         (49)         
      Inflammation, Chronic Active                                                            1 (2%)       2 (4%)                   
   Liver                                              (50)         (50)         (50)         (50)         (50)         (50)         
      Angiectasis                                      1 (2%)                                                                       
      Atrophy                                                                                                           1 (2%)      
      Basophilic Focus                                36 (72%)     31 (62%)     34 (68%)     31 (62%)     23 (46%)     28 (56%)     
      Clear Cell Focus                                 2 (4%)       4 (8%)       2 (4%)       1 (2%)       1 (2%)       1 (2%)      
      Degeneration, Cystic                             1 (2%)       2 (4%)       1 (2%)       2 (4%)       1 (2%)       1 (2%)      
      Eosinophilic Focus                                            1 (2%)                                                          
      Fibrosis                                         1 (2%)                                                                       
      Hematopoietic Cell Proliferation                              1 (2%)                                                          
      Hepatodiaphragmatic Nodule                       2 (4%)       1 (2%)                    1 (2%)       2 (4%)       1 (2%)      
      Hyperplasia                                                                1 (2%)       1 (2%)                                
      Inflammation, Chronic                           14 (28%)     17 (34%)     21 (42%)     18 (36%)     16 (32%)     20 (40%)     
      Leukocytosis                                                                                         1 (2%)                   
      Necrosis, Coagulative                            2 (4%)       1 (2%)       2 (4%)       3 (6%)       3 (6%)       1 (2%)      
      Thrombosis                                                                 1 (2%)                                             
      Vacuolization Cytoplasmic                        8 (16%)      4 (8%)       9 (18%)                   1 (2%)                   
      Hepatocyte, Hyperplasia                                                                                           1 (2%)      
   Mesentery                                          (3)          (2)          (2)          (1)          (4)          (8)          
      Inflammation, Chronic Active                     1 (33%)      1 (50%)      1 (50%)      1 (100%)     2 (50%)      5 (63%)     
      Artery, Inflammation, Chronic Active                                                                 1 (25%)                  
      Artery, Necrosis, Fibrinoid                                                                          1 (25%)                  
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05076-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 09/09/94  
Route: DOSED FEED                                                                                                 Time: 20:34:58  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0 PPM        0 PPM        25 PPM       83 PPM       83 PPM       83 PPM          
                                                   0-0          10-0         1-1           0-3          3-3          10-3           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
   Pancreas                                           (50)         (49)         (50)         (49)         (49)         (50)         
      Cyst                                                          1 (2%)                                                          
      Ectopic Liver                                                                                        1 (2%)                   
      Acinus, Atrophy                                 16 (32%)     12 (24%)     17 (34%)     15 (31%)     14 (29%)     17 (34%)     
      Artery, Necrosis, Fibrinoid                                                1 (2%)                                             
      Perivascular, Inflammation, Chronic Active                                 3 (6%)                                             
   Salivary Glands                                    (50)         (50)         (50)         (50)         (50)         (49)         
      Inflammation, Chronic Active                                                                                      1 (2%)      
      Acinus, Atrophy                                  1 (2%)                                                                       
   Stomach, Forestomach                               (49)         (49)         (50)         (49)         (48)         (50)         
      Acanthosis                                                    2 (4%)       3 (6%)       3 (6%)                    1 (2%)      
      Hyperkeratosis                                                2 (4%)       3 (6%)       3 (6%)                    1 (2%)      
      Hyperplasia, Focal, Squamous                                               1 (2%)                                             
      Inflammation, Chronic Active                     3 (6%)       3 (6%)       5 (10%)      3 (6%)       1 (2%)       2 (4%)      
      Necrosis, Coagulative                                                                                             2 (4%)      
   Stomach, Glandular                                 (48)         (49)         (50)         (48)         (48)         (50)         
      Infiltration Cellular, Lymphocyte                             1 (2%)                                                          
      Inflammation, Chronic Active                     4 (8%)       4 (8%)       3 (6%)       9 (19%)      9 (19%)      5 (10%)     
      Mineralization                                   1 (2%)       3 (6%)       5 (10%)      2 (4%)       4 (8%)       6 (12%)     
      Necrosis, Coagulative                            1 (2%)                                                                       
      Mucosa, Degeneration, Chronic                                 1 (2%)                                                          
   Tooth                                              (50)         (49)         (50)         (49)         (50)         (49)         
      Caries                                                                                               1 (2%)                   
      Inflammation, Chronic Active                     1 (2%)                                 1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)         (50)         (50)         (50)         
      Bacterium                                                                                                         1 (2%)      
      Cardiomyopathy, Chronic                         30 (60%)     25 (50%)     27 (54%)     38 (76%)     33 (66%)     35 (70%)     
      Inflammation, Chronic Active                                                                                      1 (2%)      
      Mineralization                                   1 (2%)       1 (2%)                    1 (2%)                                
      Artery, Necrosis, Fibrinoid                                                                                       1 (2%)      
      Atrium, Thrombosis                                            2 (4%)       1 (2%)       2 (4%)       1 (2%)                   
      Perivascular, Inflammation, Chronic Active                                                                        1 (2%)      
      Ventricle, Thrombosis                                                      1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (50)         (49)         (50)         (50)         (49)         (50)         
      Capsule, Inflammation, Chronic                                                                                    1 (2%)      
   Adrenal Gland, Cortex                              (50)         (49)         (49)         (48)         (49)         (50)         
      Accessory Adrenal Cortical Nodule                                                       1 (2%)                                
      Atypia Cellular                                                            2 (4%)                    1 (2%)       1 (2%)      
      Degeneration, Fatty                             16 (32%)     20 (41%)     23 (47%)     22 (46%)     20 (41%)     23 (46%)     
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05076-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 09/09/94  
Route: DOSED FEED                                                                                                 Time: 20:34:58  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0 PPM        0 PPM        25 PPM       83 PPM       83 PPM       83 PPM          
                                                   0-0          10-0         1-1           0-3          3-3          10-3           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Hematocyst                                                    1 (2%)                    2 (4%)                    1 (2%)      
      Hyperplasia                                     25 (50%)     33 (67%)     26 (53%)     31 (65%)     27 (55%)     36 (72%)     
      Hypertrophy                                      3 (6%)      11 (22%)      8 (16%)      7 (15%)      8 (16%)      4 (8%)      
      Hypertrophy, Focal                                                                                                1 (2%)      
      Necrosis, Coagulative                            2 (4%)       1 (2%)                    2 (4%)                    2 (4%)      
   Adrenal Gland, Medulla                             (50)         (49)         (49)         (49)         (49)         (50)         
      Hematocyst                                                    1 (2%)                                                          
      Hyperplasia                                     11 (22%)     16 (33%)      8 (16%)     14 (29%)     15 (31%)     13 (26%)     
      Infiltration Cellular, Lymphocyte                                                                                 1 (2%)      
   Islets, Pancreatic                                 (50)         (49)         (50)         (50)         (50)         (50)         
      Hyperplasia                                                                                                       1 (2%)      
   Parathyroid Gland                                  (46)         (47)         (48)         (46)         (46)         (47)         
      Hyperplasia                                      2 (4%)       3 (6%)       1 (2%)       1 (2%)       1 (2%)       2 (4%)      
   Pituitary Gland                                    (50)         (50)         (49)         (49)         (49)         (49)         
      Pars Distalis, Angiectasis                                    1 (2%)                    1 (2%)                    2 (4%)      
      Pars Distalis, Atypia Cellular                                                          1 (2%)                                
      Pars Distalis, Cyst                             27 (54%)     17 (34%)     27 (55%)     28 (57%)     29 (59%)     31 (63%)     
      Pars Distalis, Fibrosis                                                                              1 (2%)                   
      Pars Distalis, Hemorrhage                                                               1 (2%)                                
      Pars Distalis, Hyperplasia                      18 (36%)     12 (24%)     13 (27%)     13 (27%)     12 (24%)     12 (24%)     
      Pars Distalis, Vacuolization Cytoplasmic                                                             1 (2%)                   
      Pars Intermedia, Angiectasis                     1 (2%)                                                                       
      Pars Intermedia, Cyst                            1 (2%)       1 (2%)       1 (2%)       1 (2%)                                
   Thyroid Gland                                      (50)         (48)         (49)         (44)         (46)         (47)         
      Inflammation, Chronic Active                                  1 (2%)                                                          
      Ultimobranchial Cyst                             1 (2%)       3 (6%)       1 (2%)       3 (7%)       2 (4%)                   
      Artery, Inflammation, Chronic Active                                                                 1 (2%)                   
      Artery, Necrosis, Fibrinoid                                                                          1 (2%)                   
      C-Cell, Hyperplasia                             31 (62%)     36 (75%)     41 (84%)     35 (80%)     33 (72%)     39 (83%)     
      Follicular Cell, Hyperplasia                                  8 (17%)     15 (31%)     33 (75%)     30 (65%)     41 (87%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (48)         (50)         (49)         (47)         (49)         (45)         
      Hyperplasia                                      3 (6%)       4 (8%)       3 (6%)       3 (6%)       2 (4%)                   
      Inflammation, Chronic Active                    11 (23%)     11 (22%)      9 (18%)     15 (32%)      8 (16%)     14 (31%)     
      Duct, Dilatation                                11 (23%)     14 (28%)      8 (16%)      8 (17%)      6 (12%)     13 (29%)     
   Ovary                                              (50)         (50)         (50)         (50)         (50)         (50)         
      Atrophy                                                       2 (4%)       3 (6%)       3 (6%)       2 (4%)       1 (2%)      
      Cyst                                            11 (22%)     19 (38%)     18 (36%)     21 (42%)     14 (28%)     13 (26%)     
      Inflammation, Chronic Active                                               1 (2%)                    1 (2%)                   
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05076-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 09/09/94  
Route: DOSED FEED                                                                                                 Time: 20:34:58  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0 PPM        0 PPM        25 PPM       83 PPM       83 PPM       83 PPM          
                                                   0-0          10-0         1-1           0-3          3-3          10-3           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
   Uterus                                             (50)         (50)         (50)         (50)         (50)         (50)         
      Dilatation                                                    5 (10%)      3 (6%)       6 (12%)      1 (2%)       1 (2%)      
      Hemorrhage                                       2 (4%)       1 (2%)                    3 (6%)                    2 (4%)      
      Inflammation, Chronic Active                                  3 (6%)       1 (2%)       1 (2%)       1 (2%)                   
      Prolapse                                                      1 (2%)                                                          
      Cervix, Diverticulum                             1 (2%)       3 (6%)       1 (2%)       1 (2%)       1 (2%)                   
      Cervix, Inflammation, Suppurative                             2 (4%)       1 (2%)       1 (2%)       1 (2%)                   
      Endometrium, Hyperplasia, Cystic, Glandular     12 (24%)     12 (24%)     10 (20%)     14 (28%)     11 (22%)     15 (30%)     
   Vagina                                                          (2)                                                 (1)          
      Dilatation                                                                                                        1 (100%)    
      Epithelium, Hyperplasia                                                                                           1 (100%)    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (49)         (50)         (47)         (50)         
      Femoral, Hyperplasia, Reticulum Cell             1 (2%)       1 (2%)                    2 (4%)       1 (2%)                   
      Femoral, Myelofibrosis                           1 (2%)                                              1 (2%)       1 (2%)      
   Lymph Node                                         (50)         (49)         (50)         (50)         (50)         (50)         
      Mandibular, Cyst                                 1 (2%)                                                                       
      Mediastinal, Infiltration Cellular,                                                                                           
          Histiocyte                                                                          1 (2%)                                
   Spleen                                             (50)         (50)         (50)         (50)         (50)         (50)         
      Atrophy                                          1 (2%)       1 (2%)                                 1 (2%)                   
      Fibrosis                                         1 (2%)                    2 (4%)       2 (4%)       1 (2%)       1 (2%)      
      Hematopoietic Cell Proliferation                 3 (6%)       4 (8%)       1 (2%)                    1 (2%)       2 (4%)      
      Necrosis, Coagulative                                         1 (2%)       2 (4%)                    1 (2%)       1 (2%)      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (47)         (50)         (50)         (50)         (50)         
      Hyperplasia, Cystic                             48 (96%)     45 (96%)     50 (100%)    47 (94%)     49 (98%)     47 (94%)     
      Inflammation, Chronic Active                                               2 (4%)       1 (2%)                                
   Skin                                               (50)         (49)         (50)         (50)         (50)         (48)         
      Alopecia                                         1 (2%)                                 1 (2%)                                
      Cyst Epithelial Inclusion                                                  1 (2%)                    1 (2%)                   
      Inflammation, Chronic Active                                                            1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (49)         (50)         (50)         (50)         (50)         
      Cranium, Fibrous Osteodystrophy                  1 (2%)       2 (4%)                    2 (4%)       1 (2%)       1 (2%)      
      Femur, Fibrous Osteodystrophy                    1 (2%)       2 (4%)                    2 (4%)       1 (2%)       1 (2%)      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05076-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 09/09/94  
Route: DOSED FEED                                                                                                 Time: 20:34:58  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0 PPM        0 PPM        25 PPM       83 PPM       83 PPM       83 PPM          
                                                   0-0          10-0         1-1           0-3          3-3          10-3           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)         (50)         (50)         
      Compression                                     11 (22%)      7 (14%)      8 (16%)      9 (18%)      3 (6%)       5 (10%)     
      Hemorrhage                                       1 (2%)                                              4 (8%)                   
      Hydrocephalus                                   10 (20%)      6 (12%)      9 (18%)      8 (16%)      3 (6%)       4 (8%)      
      Inflammation, Chronic Active                                                                                      1 (2%)      
      Thrombosis                                                                              1 (2%)                                
      Artery, Inflammation, Chronic Active                                                                 1 (2%)                   
      Artery, Necrosis, Fibrinoid                                                                          1 (2%)                   
   Spinal Cord                                        (1)                                                 (1)          (1)          
      Hemorrhage                                       1 (100%)                                                                     
      White Matter, Degeneration                                                                           1 (100%)     1 (100%)    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)         (50)         (50)         
      Inflammation, Chronic Active                     7 (14%)     11 (22%)     13 (26%)     12 (24%)     10 (20%)      9 (18%)     
      Leukocytosis                                                                                         1 (2%)                   
      Necrosis, Coagulative                                                                                1 (2%)                   
      Alveolar Epithelium, Hyperplasia                              1 (2%)       2 (4%)                                             
      Artery, Mediastinum, Mineralization                           1 (2%)                                                          
      Artery, Mediastinum, Necrosis, Fibrinoid                                   1 (2%)                                             
      Bronchiole, Epithelium, Hyperplasia                                                                               1 (2%)      
      Mediastinum, Perivascular, Inflammation,                                                                                      
           Chronic Active                              1 (2%)                    2 (4%)                                             
   Nose                                               (50)         (50)         (49)         (50)         (49)         (50)         
      Foreign Body                                                                            1 (2%)                                
      Fungus                                                                                               2 (4%)       1 (2%)      
      Inflammation, Chronic Active                     3 (6%)       3 (6%)       1 (2%)                    4 (8%)       3 (6%)      
      Nasolacrimal Duct, Inflammation, Suppurative     7 (14%)      4 (8%)       5 (10%)      4 (8%)       7 (14%)      6 (12%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (8)          (9)          (7)          (7)          (12)         (10)         
      Hemorrhage                                       3 (38%)                   1 (14%)                                            
      Inflammation, Chronic Active                                               1 (14%)      1 (14%)                   1 (10%)     
      Lens, Cataract                                   6 (75%)      7 (78%)      4 (57%)      6 (86%)     11 (92%)      9 (90%)     
      Retina, Atrophy                                  6 (75%)      8 (89%)      5 (71%)      6 (86%)     10 (83%)      7 (70%)     
   Harderian Gland                                    (50)         (50)         (50)         (50)         (50)         (50)         
      Inflammation, Chronic Active                                                            1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05076-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 09/09/94  
Route: DOSED FEED                                                                                                 Time: 20:34:58  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   0 PPM        0 PPM        25 PPM       83 PPM       83 PPM       83 PPM          
                                                   0-0          10-0         1-1           0-3          3-3          10-3           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (49)         (50)         (50)         (50)         (50)         
      Cyst                                                                       1 (2%)                    1 (2%)       2 (4%)      
      Fibrosis                                         1 (2%)                                                                       
      Hydronephrosis                                                                                       1 (2%)                   
      Inflammation, Chronic Active                                                            1 (2%)                                
      Mineralization                                   1 (2%)                                                                       
      Necrosis, Coagulative                            1 (2%)                                                           2 (4%)      
      Nephropathy, Chronic                            49 (98%)     43 (88%)     46 (92%)     43 (86%)     41 (82%)     45 (90%)     
   Urinary Bladder                                    (49)         (48)         (50)         (47)         (48)         (50)         
      Dilatation                                                                                           1 (2%)                   
      Inflammation, Chronic Active                                                                                      1 (2%)      
      Transitional Epithelium, Hyperplasia                                                                              1 (2%)      
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 05076-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 09/09/94  
Route: DOSED FEED                                                                                                 Time: 20:34:58  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   250 PPM      250 PPM                                                             
                                                     0-10         10-10                                                             
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          50           50                                                               
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                26           30                                                               
    Natural Death                                      4            6                                                               
  Survivors                                                                                                                         
    Terminal Sacrifice                                20           13                                                               
    Natural Death                                                   1                                                               
  Animals Examined Microscopically                    50           50                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (46)         (48)                                                             
      Inflammation, Chronic Active                                  1 (2%)                                                          
      Parasite Metazoan                                1 (2%)                                                                       
   Intestine Large, Colon                             (46)         (49)                                                             
      Parasite Metazoan                                2 (4%)       2 (4%)                                                          
   Intestine Large, Rectum                            (45)         (49)                                                             
      Inflammation, Chronic Active                                  1 (2%)                                                          
   Intestine Small, Duodenum                          (48)         (50)                                                             
      Hyperplasia, Glandular                           1 (2%)                                                                       
   Liver                                              (50)         (50)                                                             
      Basophilic Focus                                16 (32%)     11 (22%)                                                         
      Clear Cell Focus                                 2 (4%)       4 (8%)                                                          
      Cyst                                                          1 (2%)                                                          
      Degeneration, Cystic                             3 (6%)                                                                       
      Hepatodiaphragmatic Nodule                       3 (6%)                                                                       
      Inflammation, Chronic                           15 (30%)     15 (30%)                                                         
      Leukocytosis                                     3 (6%)                                                                       
      Necrosis, Coagulative                            4 (8%)       4 (8%)                                                          
      Vacuolization Cytoplasmic                        4 (8%)       2 (4%)                                                          
      Bile Duct, Hyperplasia                           1 (2%)                                                                       
   Mesentery                                          (2)                                                                           
      Inflammation, Chronic Active                     2 (100%)                                                                     
   Pancreas                                           (49)         (50)                                                             
      Acinus, Atrophy                                 14 (29%)     10 (20%)                                                         
   Salivary Glands                                    (50)         (50)                                                             
      Granuloma                                                     1 (2%)                                                          
   Stomach, Forestomach                               (50)         (50)                                                             
      Acanthosis                                                    1 (2%)                                                          
      Hyperkeratosis                                                1 (2%)                                                          
      Inflammation, Chronic Active                     5 (10%)      6 (12%)                                                         
   Stomach, Glandular                                 (50)         (50)                                                             
      Inflammation, Chronic Active                     6 (12%)      6 (12%)                                                         
      Mineralization                                   2 (4%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 05076-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 09/09/94  
Route: DOSED FEED                                                                                                 Time: 20:34:58  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   250 PPM      250 PPM                                                             
                                                     0-10         10-10                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
   Tooth                                              (50)         (50)                                                             
      Inflammation, Chronic Active                     2 (4%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (49)                                                             
      Cardiomyopathy, Chronic                         29 (58%)     27 (55%)                                                         
      Inflammation, Chronic Active                     1 (2%)       1 (2%)                                                          
      Atrium, Thrombosis                               2 (4%)       3 (6%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (50)                                                             
      Atypia Cellular                                  1 (2%)                                                                       
      Degeneration, Fatty                             22 (44%)     15 (30%)                                                         
      Hyperplasia                                     22 (44%)     23 (46%)                                                         
      Hypertrophy                                      4 (8%)       3 (6%)                                                          
      Necrosis, Coagulative                            1 (2%)                                                                       
   Adrenal Gland, Medulla                             (50)         (50)                                                             
      Hyperplasia                                      8 (16%)     10 (20%)                                                         
   Parathyroid Gland                                  (37)         (42)                                                             
      Hyperplasia                                      3 (8%)       2 (5%)                                                          
   Pituitary Gland                                    (50)         (50)                                                             
      Pars Distalis, Atypia Cellular                                2 (4%)                                                          
      Pars Distalis, Cyst                             17 (34%)     25 (50%)                                                         
      Pars Distalis, Hyperplasia                      12 (24%)     11 (22%)                                                         
      Pars Intermedia, Cyst                            1 (2%)       3 (6%)                                                          
      Pars Nervosa, Cyst                                            1 (2%)                                                          
   Thyroid Gland                                      (49)         (50)                                                             
      Ultimobranchial Cyst                             1 (2%)                                                                       
      C-Cell, Hyperplasia                             33 (67%)     27 (54%)                                                         
      Follicular Cell, Hyperplasia                    45 (92%)     47 (94%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (47)         (47)                                                             
      Hyperplasia                                      2 (4%)       1 (2%)                                                          
      Inflammation, Chronic Active                     9 (19%)      8 (17%)                                                         
      Duct, Dilatation                                 6 (13%)      9 (19%)                                                         
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    9                                                              
NTP Experiment-Test: 05076-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 09/09/94  
Route: DOSED FEED                                                                                                 Time: 20:34:58  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   250 PPM      250 PPM                                                             
                                                     0-10         10-10                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
   Ovary                                              (50)         (50)                                                             
      Atrophy                                                       1 (2%)                                                          
      Cyst                                             9 (18%)     16 (32%)                                                         
   Uterus                                             (50)         (50)                                                             
      Dilatation                                       1 (2%)                                                                       
      Inflammation, Chronic Active                     1 (2%)                                                                       
      Cervix, Diverticulum                             2 (4%)       1 (2%)                                                          
      Cervix, Inflammation, Suppurative                2 (4%)       1 (2%)                                                          
      Endometrium, Hyperplasia, Cystic, Glandular      4 (8%)       8 (16%)                                                         
   Vagina                                             (1)                                                                           
      Inflammation, Suppurative                        1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Lymph Node                                         (50)         (50)                                                             
      Lumbar, Inflammation, Chronic Active                          1 (2%)                                                          
      Mandibular, Hyperplasia, Lymphoid                             1 (2%)                                                          
      Mandibular, Hyperplasia, Plasma Cell                          1 (2%)                                                          
      Pancreatic, Cyst                                 1 (2%)                                                                       
   Spleen                                             (50)         (50)                                                             
      Fibrosis                                         1 (2%)                                                                       
      Hematopoietic Cell Proliferation                 3 (6%)       2 (4%)                                                          
   Thymus                                             (41)         (44)                                                             
      Cyst                                             2 (5%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (50)                                                             
      Hyperplasia, Cystic                             47 (94%)     49 (98%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)                                                             
      Cranium, Fibrous Osteodystrophy                  2 (4%)       1 (2%)                                                          
      Femur, Fibrous Osteodystrophy                    2 (4%)       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)                                                             
      Compression                                      7 (14%)     13 (26%)                                                         
      Hemorrhage                                       1 (2%)       1 (2%)                                                          
      Hydrocephalus                                    8 (16%)     11 (22%)                                                         
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   10                                                              
NTP Experiment-Test: 05076-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 09/09/94  
Route: DOSED FEED                                                                                                 Time: 20:34:58  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   250 PPM      250 PPM                                                             
                                                     0-10         10-10                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)                                                             
      Fungus                                                        1 (2%)                                                          
      Inflammation, Chronic Active                     5 (10%)     10 (20%)                                                         
      Leukocytosis                                     2 (4%)                                                                       
      Alveolar Epithelium, Hyperplasia                 1 (2%)       1 (2%)                                                          
      Artery, Mediastinum, Inflammation, Chronic                                                                                    
          Active                                       1 (2%)                                                                       
      Artery, Mediastinum, Necrosis, Fibrinoid         1 (2%)                                                                       
      Mediastinum, Hemorrhage                          1 (2%)                                                                       
   Nose                                               (50)         (50)                                                             
      Foreign Body                                     1 (2%)                                                                       
      Fungus                                           2 (4%)       2 (4%)                                                          
      Hemorrhage                                       1 (2%)                                                                       
      Inflammation, Chronic Active                     4 (8%)       6 (12%)                                                         
      Mucosa, Nasolacrimal Duct, Hyperplasia                        1 (2%)                                                          
      Nasolacrimal Duct, Dilatation                                 1 (2%)                                                          
      Nasolacrimal Duct, Hyperkeratosis                             1 (2%)                                                          
      Nasolacrimal Duct, Inflammation, Suppurative     4 (8%)       5 (10%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (12)         (8)                                                              
      Hemorrhage                                       1 (8%)                                                                       
      Lens, Cataract                                   9 (75%)      5 (63%)                                                         
      Retina, Atrophy                                  8 (67%)      5 (63%)                                                         
   Harderian Gland                                    (50)         (50)                                                             
      Inflammation, Chronic Active                                  1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)                                                             
      Cyst                                             1 (2%)       1 (2%)                                                          
      Inflammation, Chronic Active                                  1 (2%)                                                          
      Necrosis, Coagulative                                         1 (2%)                                                          
      Nephropathy, Chronic                            48 (96%)     47 (94%)                                                         
   Urinary Bladder                                    (49)         (50)                                                             
      Transitional Epithelium, Hyperplasia                          1 (2%)                                                          
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   11                                                              
NTP Experiment-Test: 05076-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 09/09/94  
Route: DOSED FEED                                                                                                 Time: 20:34:58  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0 PPM        0 PPM        25 PPM       83 PPM       83 PPM       83 PPM          
                                                   0-0          10-0          1-1          0-3          3-3          10-3           
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          50           50           50           50           50           50           
  Early Deaths                                                                                                                      
    Natural Death                                     10            5            8            7            7           10           
    Moribund Sacrifice                                21           27           20           26           23           25           
  Survivors                                                                                                                         
    Terminal Sacrifice                                18           15           17           15           18           14           
    Natural Death                                      1            1            3                         1            1           
    Moribund Sacrifice                                              2            2            2            1                        
  Animals Examined Microscopically                    50           50           50           50           50           50           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (50)         (50)         (50)         (50)         (50)         (50)         
      Hemorrhage                                                                                                        1 (2%)      
   Intestine Large, Cecum                             (45)         (47)         (40)         (44)         (43)         (43)         
      Inflammation, Chronic Active                     1 (2%)       1 (2%)                    2 (5%)       1 (2%)                   
      Parasite Metazoan                                                          1 (3%)       1 (2%)                                
      Perivascular, Inflammation, Chronic Active                    5 (11%)                                                         
   Intestine Large, Colon                             (48)         (49)         (42)         (45)         (45)         (50)         
      Necrosis, Coagulative                                                                   1 (2%)                                
      Parasite Metazoan                                3 (6%)       1 (2%)       3 (7%)       3 (7%)       2 (4%)       3 (6%)      
   Intestine Large, Rectum                            (47)         (46)         (40)         (43)         (44)         (45)         
      Edema                                                                                                1 (2%)                   
      Inflammation, Chronic Active                                  1 (2%)                                                          
      Parasite Metazoan                                7 (15%)      2 (4%)       3 (8%)       9 (21%)      5 (11%)      5 (11%)     
      Artery, Necrosis, Fibrinoid                      1 (2%)                                                                       
      Perivascular, Inflammation, Chronic Active       1 (2%)                                                                       
   Intestine Small, Duodenum                          (48)         (49)         (46)         (47)         (49)         (49)         
      Inflammation, Chronic Active                     1 (2%)                    1 (2%)       1 (2%)                                
      Necrosis, Coagulative                                                                                             1 (2%)      
   Intestine Small, Ileum                             (45)         (47)         (42)         (43)         (45)         (46)         
      Edema                                                                                                1 (2%)                   
      Necrosis, Coagulative                                                                   1 (2%)                                
   Intestine Small, Jejunum                           (48)         (49)         (44)         (46)         (47)         (50)         
      Dilatation                                                                              1 (2%)                                
      Edema                                                                                                1 (2%)                   
      Inflammation, Chronic Active                                               1 (2%)       1 (2%)                                
      Metaplasia, Osseous                                                                     1 (2%)                                
   Liver                                              (50)         (50)         (50)         (50)         (50)         (50)         
      Basophilic Focus                                12 (24%)      4 (8%)       9 (18%)      7 (14%)     14 (28%)      5 (10%)     
      Clear Cell Focus                                 1 (2%)       2 (4%)                    2 (4%)       2 (4%)       1 (2%)      
      Cyst                                                                                                 1 (2%)                   
      Degeneration, Cystic                            17 (34%)     19 (38%)     18 (36%)     13 (26%)     20 (40%)     21 (42%)     
      Eosinophilic Focus                                            1 (2%)                                                          
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   12                                                              
NTP Experiment-Test: 05076-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 09/09/94  
Route: DOSED FEED                                                                                                 Time: 20:34:58  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0 PPM        0 PPM        25 PPM       83 PPM       83 PPM       83 PPM          
                                                   0-0          10-0          1-1          0-3          3-3          10-3           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Hematopoietic Cell Proliferation                 1 (2%)                                                                       
      Hepatodiaphragmatic Nodule                       1 (2%)                                                                       
      Hepatodiaphragmatic Nodule, Multiple                                                    1 (2%)                                
      Hyperplasia                                                                1 (2%)                                 2 (4%)      
      Inflammation, Chronic                            2 (4%)       3 (6%)       7 (14%)      3 (6%)       1 (2%)       1 (2%)      
      Leukocytosis                                                                            1 (2%)       1 (2%)                   
      Necrosis, Coagulative                            2 (4%)       4 (8%)       3 (6%)       4 (8%)                    6 (12%)     
      Vacuolization Cytoplasmic                        1 (2%)       1 (2%)       2 (4%)                    2 (4%)                   
      Bile Duct, Hyperplasia                                        4 (8%)                    1 (2%)       1 (2%)                   
   Mesentery                                          (3)          (5)          (6)          (2)          (2)          (3)          
      Hemorrhage                                                                 1 (17%)                                            
      Inflammation, Chronic Active                     3 (100%)     2 (40%)      4 (67%)      1 (50%)      1 (50%)      1 (33%)     
      Thrombosis                                                                                           1 (50%)                  
   Pancreas                                           (48)         (50)         (50)         (50)         (49)         (50)         
      Cyst                                             1 (2%)                    1 (2%)                                 1 (2%)      
      Inflammation, Chronic Active                                  1 (2%)                                              1 (2%)      
      Acinus, Atrophy                                 20 (42%)     30 (60%)     24 (48%)     24 (48%)     27 (55%)     18 (36%)     
      Acinus, Hyperplasia                              1 (2%)                                                                       
      Acinus, Hyperplasia, Focal                                                 1 (2%)                    1 (2%)                   
      Artery, Necrosis, Fibrinoid                      1 (2%)                                                                       
      Perivascular, Inflammation, Chronic Active       1 (2%)       3 (6%)       1 (2%)       1 (2%)       5 (10%)                  
   Salivary Glands                                    (50)         (49)         (50)         (50)         (50)         (50)         
      Inflammation, Chronic Active                     1 (2%)                                              1 (2%)                   
   Stomach, Forestomach                               (49)         (50)         (47)         (50)         (48)         (49)         
      Acanthosis                                       4 (8%)                    3 (6%)       2 (4%)       4 (8%)       3 (6%)      
      Hyperkeratosis                                   4 (8%)                    3 (6%)       2 (4%)       4 (8%)       3 (6%)      
      Hyperplasia                                                                             1 (2%)                                
      Hyperplasia, Squamous                            1 (2%)                                                           1 (2%)      
      Inflammation, Chronic Active                     3 (6%)       4 (8%)       3 (6%)       5 (10%)      6 (13%)      3 (6%)      
   Stomach, Glandular                                 (49)         (50)         (47)         (49)         (49)         (49)         
      Cyst Epithelial Inclusion                                                               1 (2%)                                
      Inflammation, Chronic Active                     1 (2%)       2 (4%)       3 (6%)       4 (8%)       6 (12%)                  
      Mineralization                                   2 (4%)       4 (8%)       1 (2%)       2 (4%)       2 (4%)       3 (6%)      
      Necrosis, Coagulative                            1 (2%)                                                           1 (2%)      
   Tooth                                              (50)         (50)         (49)         (50)         (50)         (50)         
      Cyst                                             1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)         (50)         (50)         (50)         
      Cardiomyopathy, Chronic                         46 (92%)     44 (88%)     47 (94%)     41 (82%)     44 (88%)     47 (94%)     
      Inflammation, Chronic Active                     1 (2%)       1 (2%)                    1 (2%)                                
      Mineralization                                   2 (4%)                    1 (2%)       2 (4%)       1 (2%)       3 (6%)      
      Atrium, Thrombosis                               3 (6%)       8 (16%)      1 (2%)       7 (14%)      1 (2%)       4 (8%)      
      Ventricle, Thrombosis                                         1 (2%)                                                          
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   13                                                              
NTP Experiment-Test: 05076-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 09/09/94  
Route: DOSED FEED                                                                                                 Time: 20:34:58  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0 PPM        0 PPM        25 PPM       83 PPM       83 PPM       83 PPM          
                                                   0-0          10-0          1-1          0-3          3-3          10-3           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (50)         (49)         (50)         (49)         (50)         
      Accessory Adrenal Cortical Nodule                                                                                 1 (2%)      
      Degeneration, Fatty                             14 (28%)     15 (30%)     11 (22%)     15 (30%)     13 (27%)     10 (20%)     
      Hyperplasia                                     15 (30%)     18 (36%)     19 (39%)     17 (34%)     21 (43%)     16 (32%)     
      Hypertrophy                                      4 (8%)       2 (4%)       5 (10%)      2 (4%)       5 (10%)      5 (10%)     
      Necrosis, Coagulative                                         1 (2%)                                 1 (2%)                   
   Adrenal Gland, Medulla                             (50)         (50)         (49)         (49)         (49)         (50)         
      Hematocyst                                                                                                        1 (2%)      
      Hyperplasia                                     21 (42%)     21 (42%)     23 (47%)     21 (43%)     30 (61%)     21 (42%)     
      Necrosis, Coagulative                                         1 (2%)                                                          
   Islets, Pancreatic                                 (48)         (50)         (50)         (50)         (49)         (50)         
      Hyperplasia, Focal                                                                                                1 (2%)      
   Parathyroid Gland                                  (44)         (46)         (48)         (45)         (45)         (47)         
      Hyperplasia                                      8 (18%)      5 (11%)      3 (6%)       4 (9%)       6 (13%)      5 (11%)     
   Pituitary Gland                                    (50)         (50)         (48)         (47)         (49)         (49)         
      Pars Distalis, Angiectasis                                    1 (2%)                                                          
      Pars Distalis, Cyst                              4 (8%)       3 (6%)       4 (8%)       4 (9%)       7 (14%)      3 (6%)      
      Pars Distalis, Hemorrhage                                                               2 (4%)       4 (8%)                   
      Pars Distalis, Hyperplasia                      12 (24%)      9 (18%)     12 (25%)      9 (19%)     10 (20%)     12 (24%)     
      Pars Distalis, Vacuolization Cytoplasmic                      1 (2%)                                                          
      Pars Intermedia, Cyst                            1 (2%)       2 (4%)       3 (6%)       4 (9%)       5 (10%)      4 (8%)      
      Rathke's Cleft, Cyst                                                       1 (2%)                                             
   Thyroid Gland                                      (49)         (49)         (46)         (46)         (47)         (50)         
      Inflammation, Chronic Active                                  1 (2%)                                                          
      Ultimobranchial Cyst                                          3 (6%)                                                          
      C-Cell, Hyperplasia                             29 (59%)     33 (67%)     22 (48%)     30 (65%)     35 (74%)     27 (54%)     
      Follicle, Cyst                                   1 (2%)                                                                       
      Follicular Cell, Hyperplasia                     4 (8%)      12 (24%)     13 (28%)     30 (65%)     35 (74%)     47 (94%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Coagulating Gland                                               (3)                                                              
      Inflammation, Chronic Active                                  2 (67%)                                                         
   Epididymis                                         (50)         (50)         (50)         (50)         (49)         (50)         
      Inflammation, Chronic Active                     1 (2%)                    1 (2%)                                             
      Perivascular, Inflammation, Chronic Active                    1 (2%)                                                          
   Preputial Gland                                    (49)         (49)         (49)         (49)         (46)         (50)         
      Hyperplasia                                      3 (6%)       1 (2%)       1 (2%)                    1 (2%)       2 (4%)      
      Hypertrophy                                                                                                       1 (2%)      
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   14                                                              
NTP Experiment-Test: 05076-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 09/09/94  
Route: DOSED FEED                                                                                                 Time: 20:34:58  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0 PPM        0 PPM        25 PPM       83 PPM       83 PPM       83 PPM          
                                                   0-0          10-0          1-1          0-3          3-3          10-3           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Inflammation, Chronic                                         1 (2%)                                                          
      Inflammation, Chronic Active                    45 (92%)     45 (92%)     46 (94%)     46 (94%)     42 (91%)     47 (94%)     
      Duct, Dilatation                                              1 (2%)       1 (2%)                    1 (2%)                   
   Prostate                                           (50)         (50)         (50)         (50)         (50)         (49)         
      Cyst                                                                       1 (2%)       3 (6%)                    1 (2%)      
      Inflammation, Chronic Active                    29 (58%)     27 (54%)     23 (46%)     24 (48%)     21 (42%)     25 (51%)     
      Epithelium, Hyperplasia                                                                 1 (2%)                    2 (4%)      
   Seminal Vesicle                                    (1)          (1)          (4)          (1)                                    
      Inflammation, Chronic Active                                               1 (25%)      1 (100%)                              
   Testes                                             (50)         (50)         (50)         (50)         (50)         (50)         
      Cyst                                                                       1 (2%)                                             
      Inflammation, Chronic Active                     1 (2%)                                                                       
      Necrosis, Coagulative                            1 (2%)                                                           1 (2%)      
      Interstitial Cell, Hyperplasia                   9 (18%)     12 (24%)      9 (18%)      7 (14%)      4 (8%)       5 (10%)     
      Seminiferous Tubule, Atrophy                     9 (18%)      8 (16%)     11 (22%)     11 (22%)      8 (16%)      6 (12%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (50)         (49)         (50)         
      Femoral, Hyperplasia, Reticulum Cell                          1 (2%)                    1 (2%)                                
      Femoral, Myelofibrosis                           1 (2%)       1 (2%)                    1 (2%)       1 (2%)                   
      Femoral, Myeloid Cell, Atrophy                                                                                    1 (2%)      
      Femoral, Myeloid Cell, Hyperplasia               1 (2%)                                                                       
   Lymph Node                                         (50)         (50)         (50)         (50)         (48)         (50)         
      Inguinal, Necrosis                                                                                   1 (2%)                   
      Mandibular, Cyst                                 1 (2%)       2 (4%)       1 (2%)                    3 (6%)       2 (4%)      
      Mandibular, Hyperplasia, Lymphoid                             1 (2%)                    1 (2%)                                
      Mandibular, Hyperplasia, Plasma Cell             2 (4%)                                 1 (2%)                    1 (2%)      
      Mandibular, Necrosis                                          1 (2%)                                 1 (2%)                   
      Mediastinal, Cyst                                             2 (4%)                                 1 (2%)                   
      Mediastinal, Inflammation, Chronic Active        1 (2%)                                                                       
      Mediastinal, Inflammation, Suppurative                                                  1 (2%)                                
      Renal, Infiltration Cellular, Histiocyte                                                1 (2%)                                
   Lymph Node, Mesenteric                             (2)          (10)         (14)         (10)         (9)          (10)         
      Cyst                                                                                                              1 (10%)     
      Necrosis                                                      1 (10%)                                                         
   Spleen                                             (50)         (50)         (50)         (50)         (50)         (50)         
      Fibrosis                                         6 (12%)      8 (16%)      2 (4%)       4 (8%)       3 (6%)       4 (8%)      
      Hematopoietic Cell Proliferation                 1 (2%)       3 (6%)       1 (2%)       1 (2%)                    2 (4%)      
      Necrosis, Coagulative                                                      2 (4%)       1 (2%)       1 (2%)       1 (2%)      
      Thrombosis                                       1 (2%)                                              2 (4%)                   
   Thymus                                             (40)         (39)         (45)         (42)         (40)         (38)         
      Cyst                                                                                    1 (2%)                                
      Ectopic Parathyroid Gland                                                                                         1 (3%)      
      Necrosis                                                                                             1 (3%)                   
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   15                                                              
NTP Experiment-Test: 05076-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 09/09/94  
Route: DOSED FEED                                                                                                 Time: 20:34:58  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0 PPM        0 PPM        25 PPM       83 PPM       83 PPM       83 PPM          
                                                   0-0          10-0          1-1          0-3          3-3          10-3           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (42)         (40)         (42)         (37)         (45)         (41)         
      Hyperplasia, Cystic                             42 (100%)    36 (90%)     39 (93%)     35 (95%)     40 (89%)     37 (90%)     
   Skin                                               (50)         (49)         (50)         (50)         (49)         (50)         
      Abscess                                                                                              1 (2%)                   
      Acanthosis                                                    1 (2%)                    1 (2%)                                
      Cyst Epithelial Inclusion                                                                            1 (2%)       1 (2%)      
      Hyperkeratosis                                                1 (2%)                                                          
      Hyperplasia, Basal Cell                                                                 1 (2%)                                
      Inflammation, Chronic Active                     1 (2%)                    2 (4%)                                 1 (2%)      
      Subcutaneous Tissue, Fibrosis                                 1 (2%)                                                          
      Vein, Dilatation                                                                        1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)         (50)         (50)         
      Cranium, Fibrous Osteodystrophy                  4 (8%)       4 (8%)       3 (6%)       1 (2%)       6 (12%)      3 (6%)      
      Femur, Fibrous Osteodystrophy                    4 (8%)       4 (8%)       3 (6%)       1 (2%)       6 (12%)      3 (6%)      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)         (50)         (50)         
      Compression                                      5 (10%)      5 (10%)      1 (2%)       5 (10%)      3 (6%)                   
      Hemorrhage                                       1 (2%)       2 (4%)       1 (2%)       3 (6%)       3 (6%)       1 (2%)      
      Hydrocephalus                                    4 (8%)       5 (10%)      2 (4%)       5 (10%)      3 (6%)                   
      Necrosis                                         1 (2%)       1 (2%)                                                          
   Peripheral Nerve                                   (2)                                    (1)          (1)                       
      Sciatic, Degeneration                                                                   1 (100%)                              
   Spinal Cord                                        (2)                                    (1)          (2)                       
      Hemorrhage                                       1 (50%)                                                                      
      White Matter, Degeneration                       2 (100%)                               1 (100%)     1 (50%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)         (50)         (50)         
      Granuloma                                        1 (2%)                                                                       
      Hemorrhage                                       1 (2%)                                              1 (2%)                   
      Inflammation, Chronic Active                     9 (18%)      4 (8%)       5 (10%)      5 (10%)      5 (10%)      3 (6%)      
      Leukocytosis                                                                            1 (2%)                                
      Metaplasia, Osseous                                                        1 (2%)                    1 (2%)                   
      Mineralization                                   1 (2%)                                                                       
      Necrosis, Coagulative                                                                   1 (2%)                                
      Alveolar Epithelium, Hyperplasia                 1 (2%)       1 (2%)                    2 (4%)       2 (4%)                   
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   16                                                              
NTP Experiment-Test: 05076-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 09/09/94  
Route: DOSED FEED                                                                                                 Time: 20:34:58  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0 PPM        0 PPM        25 PPM       83 PPM       83 PPM       83 PPM          
                                                   0-0          10-0          1-1          0-3          3-3          10-3           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Artery, Mediastinum, Necrosis, Fibrinoid                                                             1 (2%)                   
      Mediastinum, Mineralization                                                                                       1 (2%)      
      Mediastinum, Perivascular, Inflammation,                                                                                      
           Chronic Active                                           1 (2%)                                 1 (2%)                   
   Nose                                               (50)         (50)         (50)         (50)         (49)         (50)         
      Cyst                                                                                    1 (2%)                                
      Fungus                                           5 (10%)                   1 (2%)       5 (10%)                   1 (2%)      
      Hemorrhage                                                    1 (2%)                                                          
      Inflammation, Chronic Active                    15 (30%)     10 (20%)     12 (24%)     11 (22%)     13 (27%)     13 (26%)     
      Nasolacrimal Duct, Hyperkeratosis                                                                    1 (2%)                   
      Nasolacrimal Duct, Inflammation, Suppurative     6 (12%)      4 (8%)       7 (14%)      5 (10%)      8 (16%)      5 (10%)     
   Trachea                                            (50)         (50)         (50)         (50)         (50)         (50)         
      Cyst                                                                       1 (2%)                                             
      Hemorrhage                                                                                                        1 (2%)      
      Inflammation, Chronic Active                                                                                      1 (2%)      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (11)         (10)         (6)          (8)          (4)          (5)          
      Hemorrhage                                       1 (9%)                                                           1 (20%)     
      Inflammation, Chronic Active                     1 (9%)                                                           1 (20%)     
      Lens, Cataract                                   9 (82%)      7 (70%)      4 (67%)      6 (75%)      3 (75%)      3 (60%)     
      Retina, Atrophy                                 10 (91%)      9 (90%)      4 (67%)      6 (75%)      3 (75%)      3 (60%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (49)         (50)         (50)         (50)         
      Bacterium                                                                  1 (2%)                                             
      Hydronephrosis                                   1 (2%)                                                                       
      Infarct                                                       1 (2%)                                                          
      Infiltration Cellular, Mixed Cell                                                                    1 (2%)                   
      Inflammation, Chronic Active                                               1 (2%)                    1 (2%)                   
      Necrosis, Coagulative                                                                   2 (4%)                                
      Nephropathy, Chronic                            49 (98%)     50 (100%)    47 (96%)     49 (98%)     49 (98%)     50 (100%)    
      Artery, Necrosis, Fibrinoid                      1 (2%)                                                                       
      Perivascular, Inflammation, Chronic Active       1 (2%)                                                                       
      Renal Tubule, Hyperplasia                                                                            1 (2%)                   
      Renal Tubule, Mineralization                                               1 (2%)                                             
      Renal Tubule, Epithelium, Hyperplasia                         3 (6%)       1 (2%)                                 3 (6%)      
   Urethra                                            (1)                                                                           
      Transitional Epithelium, Hyperplasia             1 (100%)                                                                     
   Urinary Bladder                                    (49)         (50)         (48)         (49)         (48)         (50)         
      Dilatation                                       1 (2%)                                                                       
      Hemorrhage                                       1 (2%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   17                                                              
NTP Experiment-Test: 05076-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 09/09/94  
Route: DOSED FEED                                                                                                 Time: 20:34:58  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     0 PPM        0 PPM        25 PPM       83 PPM       83 PPM       83 PPM          
                                                   0-0          10-0          1-1          0-3          3-3          10-3           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Inflammation, Chronic Active                                  1 (2%)       1 (2%)                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   18                                                              
NTP Experiment-Test: 05076-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 09/09/94  
Route: DOSED FEED                                                                                                 Time: 20:34:58  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     250 PPM      250 PPM                                                             
                                                     0-10        10-10                                                              
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          50           50                                                               
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                23           30                                                               
    Natural Death                                      8           14                                                               
    Accidently Killed                                  5                                                                            
  Survivors                                                                                                                         
    Moribund Sacrifice                                              1                                                               
    Natural Death                                                   1                                                               
    Terminal Sacrifice                                14            4                                                               
  Animals Examined Microscopically                    50           50                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (50)         (50)                                                             
      Inflammation, Chronic Active                                  1 (2%)                                                          
   Intestine Large, Cecum                             (44)         (39)                                                             
      Artery, Inflammation, Chronic Active                          1 (3%)                                                          
   Intestine Large, Colon                             (47)         (47)                                                             
      Parasite Metazoan                                2 (4%)       3 (6%)                                                          
   Intestine Large, Rectum                            (43)         (45)                                                             
      Parasite Metazoan                                4 (9%)       3 (7%)                                                          
      Artery, Inflammation, Chronic Active                          1 (2%)                                                          
   Intestine Small, Duodenum                          (50)         (49)                                                             
      Inflammation, Chronic Active                                  1 (2%)                                                          
      Necrosis, Coagulative                                         1 (2%)                                                          
   Liver                                              (50)         (50)                                                             
      Angiectasis                                      2 (4%)       2 (4%)                                                          
      Basophilic Focus                                15 (30%)      3 (6%)                                                          
      Clear Cell Focus                                              4 (8%)                                                          
      Degeneration, Cystic                            25 (50%)     17 (34%)                                                         
      Inflammation, Chronic                           10 (20%)      3 (6%)                                                          
      Leukocytosis                                                  1 (2%)                                                          
      Necrosis, Coagulative                            6 (12%)      4 (8%)                                                          
      Thrombosis                                                    1 (2%)                                                          
      Vacuolization Cytoplasmic                        2 (4%)       1 (2%)                                                          
   Mesentery                                          (2)          (3)                                                              
      Inflammation, Chronic Active                     2 (100%)                                                                     
      Artery, Inflammation, Chronic Active                          1 (33%)                                                         
   Pancreas                                           (49)         (50)                                                             
      Necrosis, Coagulative                            1 (2%)                                                                       
      Acinus, Atrophy                                 17 (35%)     19 (38%)                                                         
      Artery, Inflammation, Chronic Active                          1 (2%)                                                          
   Salivary Glands                                    (50)         (49)                                                             
      Inflammation, Chronic Active                                  2 (4%)                                                          
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   19                                                              
NTP Experiment-Test: 05076-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 09/09/94  
Route: DOSED FEED                                                                                                 Time: 20:34:58  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     250 PPM      250 PPM                                                             
                                                     0-10        10-10                                                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Necrosis                                                      1 (2%)                                                          
      Artery, Inflammation, Chronic Active                          1 (2%)                                                          
   Stomach, Forestomach                               (49)         (50)                                                             
      Necrosis, Coagulative                                         3 (6%)                                                          
   Stomach, Glandular                                 (49)         (49)                                                             
      Inflammation, Chronic Active                                  2 (4%)                                                          
      Mineralization                                   1 (2%)       2 (4%)                                                          
      Artery, Inflammation, Chronic Active                          1 (2%)                                                          
   Tooth                                              (49)         (50)                                                             
      Inflammation, Chronic Active                     1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)                                                             
      Cardiomyopathy, Chronic                         39 (78%)     43 (86%)                                                         
      Mineralization                                   1 (2%)                                                                       
      Artery, Inflammation, Chronic Active                          1 (2%)                                                          
      Atrium, Thrombosis                               3 (6%)       4 (8%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (50)                                                             
      Degeneration, Fatty                             14 (28%)     13 (26%)                                                         
      Hyperplasia                                      9 (18%)      6 (12%)                                                         
      Hypertrophy, Focal                                            1 (2%)                                                          
      Necrosis, Coagulative                                         1 (2%)                                                          
      Vacuolization Cytoplasmic                        1 (2%)                                                                       
   Adrenal Gland, Medulla                             (50)         (50)                                                             
      Hyperplasia                                     14 (28%)     17 (34%)                                                         
      Necrosis, Coagulative                                         1 (2%)                                                          
   Islets, Pancreatic                                 (50)         (50)                                                             
      Hyperplasia                                                   3 (6%)                                                          
      Necrosis, Coagulative                            1 (2%)                                                                       
   Pituitary Gland                                    (50)         (49)                                                             
      Pars Distalis, Atypia Cellular                   1 (2%)                                                                       
      Pars Distalis, Cyst                                           8 (16%)                                                         
      Pars Distalis, Hyperplasia                       6 (12%)     16 (33%)                                                         
      Pars Distalis, Vacuolization Cytoplasmic         1 (2%)                                                                       
   Thyroid Gland                                      (50)         (50)                                                             
      Inflammation, Chronic Active                                  1 (2%)                                                          
      Artery, Inflammation, Chronic Active                          1 (2%)                                                          
      C-Cell, Hyperplasia                             12 (24%)      9 (18%)                                                         
      Follicular Cell, Hyperplasia                    41 (82%)     39 (78%)                                                         
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   20                                                              
NTP Experiment-Test: 05076-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 09/09/94  
Route: DOSED FEED                                                                                                 Time: 20:34:58  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     250 PPM      250 PPM                                                             
                                                     0-10        10-10                                                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (49)         (50)                                                             
      Mineralization                                   1 (2%)                                                                       
   Preputial Gland                                    (49)         (50)                                                             
      Inflammation, Chronic Active                    41 (84%)     42 (84%)                                                         
   Prostate                                           (49)         (50)                                                             
      Cyst                                             2 (4%)       1 (2%)                                                          
      Inflammation, Chronic Active                    27 (55%)     27 (54%)                                                         
   Seminal Vesicle                                                 (2)                                                              
      Artery, Inflammation, Chronic Active                          1 (50%)                                                         
   Testes                                             (50)         (50)                                                             
      Artery, Inflammation, Chronic Active                          1 (2%)                                                          
      Interstitial Cell, Hyperplasia                   6 (12%)      8 (16%)                                                         
      Seminiferous Tubule, Atrophy                     8 (16%)      7 (14%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (49)         (50)                                                             
      Femoral, Myelofibrosis                                        1 (2%)                                                          
   Lymph Node                                         (50)         (49)                                                             
      Mandibular, Hyperplasia, Plasma Cell             2 (4%)       3 (6%)                                                          
   Lymph Node, Mesenteric                             (14)         (10)                                                             
      Cyst                                             1 (7%)                                                                       
   Spleen                                             (50)         (50)                                                             
      Fibrosis                                         8 (16%)      6 (12%)                                                         
      Hematopoietic Cell Proliferation                 1 (2%)                                                                       
      Necrosis, Coagulative                            2 (4%)                                                                       
      Artery, Inflammation, Chronic Active                          1 (2%)                                                          
   Thymus                                             (43)         (44)                                                             
      Ectopic Parathyroid Gland                                     1 (2%)                                                          
      Hemorrhage                                                    1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (36)         (37)                                                             
      Hyperplasia, Cystic                             31 (86%)     37 (100%)                                                        
   Skin                                               (49)         (49)                                                             
      Hyperkeratosis                                                1 (2%)                                                          
      Inflammation, Chronic Active                     1 (2%)       1 (2%)                                                          
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   21                                                              
NTP Experiment-Test: 05076-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 09/09/94  
Route: DOSED FEED                                                                                                 Time: 20:34:58  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     250 PPM      250 PPM                                                             
                                                     0-10        10-10                                                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (49)         (50)                                                             
      Femur, Fibrous Osteodystrophy                    1 (2%)                                                                       
   Skeletal Muscle                                    (5)          (2)                                                              
      Artery, Inflammation, Chronic Active                          1 (50%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)                                                             
      Compression                                      1 (2%)                                                                       
      Hemorrhage                                                    1 (2%)                                                          
      Hydrocephalus                                    1 (2%)                                                                       
      Artery, Inflammation, Chronic Active                          1 (2%)                                                          
   Peripheral Nerve                                   (6)                                                                           
      Sciatic, Degeneration                            2 (33%)                                                                      
   Spinal Cord                                        (7)                                                                           
      White Matter, Degeneration                       2 (29%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)                                                             
      Congestion                                                    1 (2%)                                                          
      Hemorrhage                                                    1 (2%)                                                          
      Inflammation, Chronic Active                     6 (12%)     10 (20%)                                                         
      Thrombosis                                       1 (2%)       1 (2%)                                                          
      Artery, Mediastinum, Inflammation, Chronic                                                                                    
          Active                                                    1 (2%)                                                          
      Vein, Mediastinum, Thrombosis                    1 (2%)                                                                       
   Nose                                               (50)         (50)                                                             
      Foreign Body                                                  1 (2%)                                                          
      Fungus                                           1 (2%)       5 (10%)                                                         
      Hemorrhage                                       3 (6%)                                                                       
      Inflammation, Chronic Active                     9 (18%)     16 (32%)                                                         
      Nasolacrimal Duct, Foreign Body                               1 (2%)                                                          
      Nasolacrimal Duct, Inflammation, Suppurative     7 (14%)      6 (12%)                                                         
   Trachea                                            (50)         (50)                                                             
      Inflammation, Chronic Active                                  1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   22                                                              
NTP Experiment-Test: 05076-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 09/09/94  
Route: DOSED FEED                                                                                                 Time: 20:34:58  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     250 PPM      250 PPM                                                             
                                                     0-10        10-10                                                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (11)         (10)                                                             
      Lens, Cataract                                   5 (45%)      9 (90%)                                                         
      Retina, Atrophy                                  5 (45%)      8 (80%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)                                                             
      Necrosis, Coagulative                            1 (2%)       1 (2%)                                                          
      Nephropathy, Chronic                            45 (90%)     50 (100%)                                                        
      Artery, Inflammation, Chronic Active                          1 (2%)                                                          
      Renal Tubule, Epithelium, Hyperplasia            7 (14%)      2 (4%)                                                          
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   23                                                              
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
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NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.