TR 388 Rat Pathology Tables
INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
ETHYLENETHIOUREA
NTP Experiment-Test: 05076-01 Report: PEIRPT03
Study Type: CHRONIC Date: 09/09/94
Route: DOSED FEED Time: 20:34:58
Facility: Battelle Columbus Laboratory
Chemical CAS #: 96-45-7
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05076-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ETHYLENETHIOUREA Date: 09/09/94
Route: DOSED FEED Time: 20:34:58
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 0 PPM 25 PPM 83 PPM 83 PPM 83 PPM
0-0 10-0 1-1 0-3 3-3 10-3
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50 50 50
Early Deaths
Moribund Sacrifice 20 15 13 8 10 13
Natural Death 6 5 3 9 13 4
Survivors
Moribund Sacrifice 2 1
Terminal Sacrifice 23 30 34 30 26 32
Natural Death 1 1 1
Animals Examined Microscopically 50 50 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (50) (50) (49) (50) (49) (50)
Foreign Body 1 (2%)
Intestine Large, Cecum (46) (46) (48) (42) (39) (46)
Artery, Necrosis, Fibrinoid 1 (2%)
Perivascular, Inflammation, Chronic Active 1 (2%)
Intestine Large, Colon (47) (47) (50) (45) (43) (47)
Parasite Metazoan 1 (2%) 1 (2%) 1 (2%) 1 (2%)
Intestine Large, Rectum (48) (46) (49) (43) (41) (47)
Parasite Metazoan 2 (4%) 6 (13%) 4 (8%) 2 (5%) 7 (17%) 4 (9%)
Intestine Small, Duodenum (49) (49) (50) (48) (48) (49)
Inflammation, Chronic Active 1 (2%) 2 (4%)
Liver (50) (50) (50) (50) (50) (50)
Angiectasis 1 (2%)
Atrophy 1 (2%)
Basophilic Focus 36 (72%) 31 (62%) 34 (68%) 31 (62%) 23 (46%) 28 (56%)
Clear Cell Focus 2 (4%) 4 (8%) 2 (4%) 1 (2%) 1 (2%) 1 (2%)
Degeneration, Cystic 1 (2%) 2 (4%) 1 (2%) 2 (4%) 1 (2%) 1 (2%)
Eosinophilic Focus 1 (2%)
Fibrosis 1 (2%)
Hematopoietic Cell Proliferation 1 (2%)
Hepatodiaphragmatic Nodule 2 (4%) 1 (2%) 1 (2%) 2 (4%) 1 (2%)
Hyperplasia 1 (2%) 1 (2%)
Inflammation, Chronic 14 (28%) 17 (34%) 21 (42%) 18 (36%) 16 (32%) 20 (40%)
Leukocytosis 1 (2%)
Necrosis, Coagulative 2 (4%) 1 (2%) 2 (4%) 3 (6%) 3 (6%) 1 (2%)
Thrombosis 1 (2%)
Vacuolization Cytoplasmic 8 (16%) 4 (8%) 9 (18%) 1 (2%)
Hepatocyte, Hyperplasia 1 (2%)
Mesentery (3) (2) (2) (1) (4) (8)
Inflammation, Chronic Active 1 (33%) 1 (50%) 1 (50%) 1 (100%) 2 (50%) 5 (63%)
Artery, Inflammation, Chronic Active 1 (25%)
Artery, Necrosis, Fibrinoid 1 (25%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05076-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ETHYLENETHIOUREA Date: 09/09/94
Route: DOSED FEED Time: 20:34:58
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 0 PPM 25 PPM 83 PPM 83 PPM 83 PPM
0-0 10-0 1-1 0-3 3-3 10-3
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Pancreas (50) (49) (50) (49) (49) (50)
Cyst 1 (2%)
Ectopic Liver 1 (2%)
Acinus, Atrophy 16 (32%) 12 (24%) 17 (34%) 15 (31%) 14 (29%) 17 (34%)
Artery, Necrosis, Fibrinoid 1 (2%)
Perivascular, Inflammation, Chronic Active 3 (6%)
Salivary Glands (50) (50) (50) (50) (50) (49)
Inflammation, Chronic Active 1 (2%)
Acinus, Atrophy 1 (2%)
Stomach, Forestomach (49) (49) (50) (49) (48) (50)
Acanthosis 2 (4%) 3 (6%) 3 (6%) 1 (2%)
Hyperkeratosis 2 (4%) 3 (6%) 3 (6%) 1 (2%)
Hyperplasia, Focal, Squamous 1 (2%)
Inflammation, Chronic Active 3 (6%) 3 (6%) 5 (10%) 3 (6%) 1 (2%) 2 (4%)
Necrosis, Coagulative 2 (4%)
Stomach, Glandular (48) (49) (50) (48) (48) (50)
Infiltration Cellular, Lymphocyte 1 (2%)
Inflammation, Chronic Active 4 (8%) 4 (8%) 3 (6%) 9 (19%) 9 (19%) 5 (10%)
Mineralization 1 (2%) 3 (6%) 5 (10%) 2 (4%) 4 (8%) 6 (12%)
Necrosis, Coagulative 1 (2%)
Mucosa, Degeneration, Chronic 1 (2%)
Tooth (50) (49) (50) (49) (50) (49)
Caries 1 (2%)
Inflammation, Chronic Active 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50) (50) (50) (50)
Bacterium 1 (2%)
Cardiomyopathy, Chronic 30 (60%) 25 (50%) 27 (54%) 38 (76%) 33 (66%) 35 (70%)
Inflammation, Chronic Active 1 (2%)
Mineralization 1 (2%) 1 (2%) 1 (2%)
Artery, Necrosis, Fibrinoid 1 (2%)
Atrium, Thrombosis 2 (4%) 1 (2%) 2 (4%) 1 (2%)
Perivascular, Inflammation, Chronic Active 1 (2%)
Ventricle, Thrombosis 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland (50) (49) (50) (50) (49) (50)
Capsule, Inflammation, Chronic 1 (2%)
Adrenal Gland, Cortex (50) (49) (49) (48) (49) (50)
Accessory Adrenal Cortical Nodule 1 (2%)
Atypia Cellular 2 (4%) 1 (2%) 1 (2%)
Degeneration, Fatty 16 (32%) 20 (41%) 23 (47%) 22 (46%) 20 (41%) 23 (46%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05076-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ETHYLENETHIOUREA Date: 09/09/94
Route: DOSED FEED Time: 20:34:58
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 0 PPM 25 PPM 83 PPM 83 PPM 83 PPM
0-0 10-0 1-1 0-3 3-3 10-3
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Hematocyst 1 (2%) 2 (4%) 1 (2%)
Hyperplasia 25 (50%) 33 (67%) 26 (53%) 31 (65%) 27 (55%) 36 (72%)
Hypertrophy 3 (6%) 11 (22%) 8 (16%) 7 (15%) 8 (16%) 4 (8%)
Hypertrophy, Focal 1 (2%)
Necrosis, Coagulative 2 (4%) 1 (2%) 2 (4%) 2 (4%)
Adrenal Gland, Medulla (50) (49) (49) (49) (49) (50)
Hematocyst 1 (2%)
Hyperplasia 11 (22%) 16 (33%) 8 (16%) 14 (29%) 15 (31%) 13 (26%)
Infiltration Cellular, Lymphocyte 1 (2%)
Islets, Pancreatic (50) (49) (50) (50) (50) (50)
Hyperplasia 1 (2%)
Parathyroid Gland (46) (47) (48) (46) (46) (47)
Hyperplasia 2 (4%) 3 (6%) 1 (2%) 1 (2%) 1 (2%) 2 (4%)
Pituitary Gland (50) (50) (49) (49) (49) (49)
Pars Distalis, Angiectasis 1 (2%) 1 (2%) 2 (4%)
Pars Distalis, Atypia Cellular 1 (2%)
Pars Distalis, Cyst 27 (54%) 17 (34%) 27 (55%) 28 (57%) 29 (59%) 31 (63%)
Pars Distalis, Fibrosis 1 (2%)
Pars Distalis, Hemorrhage 1 (2%)
Pars Distalis, Hyperplasia 18 (36%) 12 (24%) 13 (27%) 13 (27%) 12 (24%) 12 (24%)
Pars Distalis, Vacuolization Cytoplasmic 1 (2%)
Pars Intermedia, Angiectasis 1 (2%)
Pars Intermedia, Cyst 1 (2%) 1 (2%) 1 (2%) 1 (2%)
Thyroid Gland (50) (48) (49) (44) (46) (47)
Inflammation, Chronic Active 1 (2%)
Ultimobranchial Cyst 1 (2%) 3 (6%) 1 (2%) 3 (7%) 2 (4%)
Artery, Inflammation, Chronic Active 1 (2%)
Artery, Necrosis, Fibrinoid 1 (2%)
C-Cell, Hyperplasia 31 (62%) 36 (75%) 41 (84%) 35 (80%) 33 (72%) 39 (83%)
Follicular Cell, Hyperplasia 8 (17%) 15 (31%) 33 (75%) 30 (65%) 41 (87%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (48) (50) (49) (47) (49) (45)
Hyperplasia 3 (6%) 4 (8%) 3 (6%) 3 (6%) 2 (4%)
Inflammation, Chronic Active 11 (23%) 11 (22%) 9 (18%) 15 (32%) 8 (16%) 14 (31%)
Duct, Dilatation 11 (23%) 14 (28%) 8 (16%) 8 (17%) 6 (12%) 13 (29%)
Ovary (50) (50) (50) (50) (50) (50)
Atrophy 2 (4%) 3 (6%) 3 (6%) 2 (4%) 1 (2%)
Cyst 11 (22%) 19 (38%) 18 (36%) 21 (42%) 14 (28%) 13 (26%)
Inflammation, Chronic Active 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05076-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ETHYLENETHIOUREA Date: 09/09/94
Route: DOSED FEED Time: 20:34:58
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 0 PPM 25 PPM 83 PPM 83 PPM 83 PPM
0-0 10-0 1-1 0-3 3-3 10-3
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Uterus (50) (50) (50) (50) (50) (50)
Dilatation 5 (10%) 3 (6%) 6 (12%) 1 (2%) 1 (2%)
Hemorrhage 2 (4%) 1 (2%) 3 (6%) 2 (4%)
Inflammation, Chronic Active 3 (6%) 1 (2%) 1 (2%) 1 (2%)
Prolapse 1 (2%)
Cervix, Diverticulum 1 (2%) 3 (6%) 1 (2%) 1 (2%) 1 (2%)
Cervix, Inflammation, Suppurative 2 (4%) 1 (2%) 1 (2%) 1 (2%)
Endometrium, Hyperplasia, Cystic, Glandular 12 (24%) 12 (24%) 10 (20%) 14 (28%) 11 (22%) 15 (30%)
Vagina (2) (1)
Dilatation 1 (100%)
Epithelium, Hyperplasia 1 (100%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (49) (50) (47) (50)
Femoral, Hyperplasia, Reticulum Cell 1 (2%) 1 (2%) 2 (4%) 1 (2%)
Femoral, Myelofibrosis 1 (2%) 1 (2%) 1 (2%)
Lymph Node (50) (49) (50) (50) (50) (50)
Mandibular, Cyst 1 (2%)
Mediastinal, Infiltration Cellular,
Histiocyte 1 (2%)
Spleen (50) (50) (50) (50) (50) (50)
Atrophy 1 (2%) 1 (2%) 1 (2%)
Fibrosis 1 (2%) 2 (4%) 2 (4%) 1 (2%) 1 (2%)
Hematopoietic Cell Proliferation 3 (6%) 4 (8%) 1 (2%) 1 (2%) 2 (4%)
Necrosis, Coagulative 1 (2%) 2 (4%) 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (47) (50) (50) (50) (50)
Hyperplasia, Cystic 48 (96%) 45 (96%) 50 (100%) 47 (94%) 49 (98%) 47 (94%)
Inflammation, Chronic Active 2 (4%) 1 (2%)
Skin (50) (49) (50) (50) (50) (48)
Alopecia 1 (2%) 1 (2%)
Cyst Epithelial Inclusion 1 (2%) 1 (2%)
Inflammation, Chronic Active 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (49) (50) (50) (50) (50)
Cranium, Fibrous Osteodystrophy 1 (2%) 2 (4%) 2 (4%) 1 (2%) 1 (2%)
Femur, Fibrous Osteodystrophy 1 (2%) 2 (4%) 2 (4%) 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05076-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ETHYLENETHIOUREA Date: 09/09/94
Route: DOSED FEED Time: 20:34:58
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 0 PPM 25 PPM 83 PPM 83 PPM 83 PPM
0-0 10-0 1-1 0-3 3-3 10-3
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50) (50) (50)
Compression 11 (22%) 7 (14%) 8 (16%) 9 (18%) 3 (6%) 5 (10%)
Hemorrhage 1 (2%) 4 (8%)
Hydrocephalus 10 (20%) 6 (12%) 9 (18%) 8 (16%) 3 (6%) 4 (8%)
Inflammation, Chronic Active 1 (2%)
Thrombosis 1 (2%)
Artery, Inflammation, Chronic Active 1 (2%)
Artery, Necrosis, Fibrinoid 1 (2%)
Spinal Cord (1) (1) (1)
Hemorrhage 1 (100%)
White Matter, Degeneration 1 (100%) 1 (100%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50) (50) (50) (50)
Inflammation, Chronic Active 7 (14%) 11 (22%) 13 (26%) 12 (24%) 10 (20%) 9 (18%)
Leukocytosis 1 (2%)
Necrosis, Coagulative 1 (2%)
Alveolar Epithelium, Hyperplasia 1 (2%) 2 (4%)
Artery, Mediastinum, Mineralization 1 (2%)
Artery, Mediastinum, Necrosis, Fibrinoid 1 (2%)
Bronchiole, Epithelium, Hyperplasia 1 (2%)
Mediastinum, Perivascular, Inflammation,
Chronic Active 1 (2%) 2 (4%)
Nose (50) (50) (49) (50) (49) (50)
Foreign Body 1 (2%)
Fungus 2 (4%) 1 (2%)
Inflammation, Chronic Active 3 (6%) 3 (6%) 1 (2%) 4 (8%) 3 (6%)
Nasolacrimal Duct, Inflammation, Suppurative 7 (14%) 4 (8%) 5 (10%) 4 (8%) 7 (14%) 6 (12%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (8) (9) (7) (7) (12) (10)
Hemorrhage 3 (38%) 1 (14%)
Inflammation, Chronic Active 1 (14%) 1 (14%) 1 (10%)
Lens, Cataract 6 (75%) 7 (78%) 4 (57%) 6 (86%) 11 (92%) 9 (90%)
Retina, Atrophy 6 (75%) 8 (89%) 5 (71%) 6 (86%) 10 (83%) 7 (70%)
Harderian Gland (50) (50) (50) (50) (50) (50)
Inflammation, Chronic Active 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05076-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ETHYLENETHIOUREA Date: 09/09/94
Route: DOSED FEED Time: 20:34:58
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 PPM 0 PPM 25 PPM 83 PPM 83 PPM 83 PPM
0-0 10-0 1-1 0-3 3-3 10-3
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (49) (50) (50) (50) (50)
Cyst 1 (2%) 1 (2%) 2 (4%)
Fibrosis 1 (2%)
Hydronephrosis 1 (2%)
Inflammation, Chronic Active 1 (2%)
Mineralization 1 (2%)
Necrosis, Coagulative 1 (2%) 2 (4%)
Nephropathy, Chronic 49 (98%) 43 (88%) 46 (92%) 43 (86%) 41 (82%) 45 (90%)
Urinary Bladder (49) (48) (50) (47) (48) (50)
Dilatation 1 (2%)
Inflammation, Chronic Active 1 (2%)
Transitional Epithelium, Hyperplasia 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05076-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ETHYLENETHIOUREA Date: 09/09/94
Route: DOSED FEED Time: 20:34:58
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 250 PPM 250 PPM
0-10 10-10
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50
Early Deaths
Moribund Sacrifice 26 30
Natural Death 4 6
Survivors
Terminal Sacrifice 20 13
Natural Death 1
Animals Examined Microscopically 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Cecum (46) (48)
Inflammation, Chronic Active 1 (2%)
Parasite Metazoan 1 (2%)
Intestine Large, Colon (46) (49)
Parasite Metazoan 2 (4%) 2 (4%)
Intestine Large, Rectum (45) (49)
Inflammation, Chronic Active 1 (2%)
Intestine Small, Duodenum (48) (50)
Hyperplasia, Glandular 1 (2%)
Liver (50) (50)
Basophilic Focus 16 (32%) 11 (22%)
Clear Cell Focus 2 (4%) 4 (8%)
Cyst 1 (2%)
Degeneration, Cystic 3 (6%)
Hepatodiaphragmatic Nodule 3 (6%)
Inflammation, Chronic 15 (30%) 15 (30%)
Leukocytosis 3 (6%)
Necrosis, Coagulative 4 (8%) 4 (8%)
Vacuolization Cytoplasmic 4 (8%) 2 (4%)
Bile Duct, Hyperplasia 1 (2%)
Mesentery (2)
Inflammation, Chronic Active 2 (100%)
Pancreas (49) (50)
Acinus, Atrophy 14 (29%) 10 (20%)
Salivary Glands (50) (50)
Granuloma 1 (2%)
Stomach, Forestomach (50) (50)
Acanthosis 1 (2%)
Hyperkeratosis 1 (2%)
Inflammation, Chronic Active 5 (10%) 6 (12%)
Stomach, Glandular (50) (50)
Inflammation, Chronic Active 6 (12%) 6 (12%)
Mineralization 2 (4%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 05076-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ETHYLENETHIOUREA Date: 09/09/94
Route: DOSED FEED Time: 20:34:58
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 250 PPM 250 PPM
0-10 10-10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Tooth (50) (50)
Inflammation, Chronic Active 2 (4%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (49)
Cardiomyopathy, Chronic 29 (58%) 27 (55%)
Inflammation, Chronic Active 1 (2%) 1 (2%)
Atrium, Thrombosis 2 (4%) 3 (6%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (50) (50)
Atypia Cellular 1 (2%)
Degeneration, Fatty 22 (44%) 15 (30%)
Hyperplasia 22 (44%) 23 (46%)
Hypertrophy 4 (8%) 3 (6%)
Necrosis, Coagulative 1 (2%)
Adrenal Gland, Medulla (50) (50)
Hyperplasia 8 (16%) 10 (20%)
Parathyroid Gland (37) (42)
Hyperplasia 3 (8%) 2 (5%)
Pituitary Gland (50) (50)
Pars Distalis, Atypia Cellular 2 (4%)
Pars Distalis, Cyst 17 (34%) 25 (50%)
Pars Distalis, Hyperplasia 12 (24%) 11 (22%)
Pars Intermedia, Cyst 1 (2%) 3 (6%)
Pars Nervosa, Cyst 1 (2%)
Thyroid Gland (49) (50)
Ultimobranchial Cyst 1 (2%)
C-Cell, Hyperplasia 33 (67%) 27 (54%)
Follicular Cell, Hyperplasia 45 (92%) 47 (94%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (47) (47)
Hyperplasia 2 (4%) 1 (2%)
Inflammation, Chronic Active 9 (19%) 8 (17%)
Duct, Dilatation 6 (13%) 9 (19%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 05076-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ETHYLENETHIOUREA Date: 09/09/94
Route: DOSED FEED Time: 20:34:58
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 250 PPM 250 PPM
0-10 10-10
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Ovary (50) (50)
Atrophy 1 (2%)
Cyst 9 (18%) 16 (32%)
Uterus (50) (50)
Dilatation 1 (2%)
Inflammation, Chronic Active 1 (2%)
Cervix, Diverticulum 2 (4%) 1 (2%)
Cervix, Inflammation, Suppurative 2 (4%) 1 (2%)
Endometrium, Hyperplasia, Cystic, Glandular 4 (8%) 8 (16%)
Vagina (1)
Inflammation, Suppurative 1 (100%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node (50) (50)
Lumbar, Inflammation, Chronic Active 1 (2%)
Mandibular, Hyperplasia, Lymphoid 1 (2%)
Mandibular, Hyperplasia, Plasma Cell 1 (2%)
Pancreatic, Cyst 1 (2%)
Spleen (50) (50)
Fibrosis 1 (2%)
Hematopoietic Cell Proliferation 3 (6%) 2 (4%)
Thymus (41) (44)
Cyst 2 (5%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (50)
Hyperplasia, Cystic 47 (94%) 49 (98%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50)
Cranium, Fibrous Osteodystrophy 2 (4%) 1 (2%)
Femur, Fibrous Osteodystrophy 2 (4%) 1 (2%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50)
Compression 7 (14%) 13 (26%)
Hemorrhage 1 (2%) 1 (2%)
Hydrocephalus 8 (16%) 11 (22%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 05076-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ETHYLENETHIOUREA Date: 09/09/94
Route: DOSED FEED Time: 20:34:58
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 250 PPM 250 PPM
0-10 10-10
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50)
Fungus 1 (2%)
Inflammation, Chronic Active 5 (10%) 10 (20%)
Leukocytosis 2 (4%)
Alveolar Epithelium, Hyperplasia 1 (2%) 1 (2%)
Artery, Mediastinum, Inflammation, Chronic
Active 1 (2%)
Artery, Mediastinum, Necrosis, Fibrinoid 1 (2%)
Mediastinum, Hemorrhage 1 (2%)
Nose (50) (50)
Foreign Body 1 (2%)
Fungus 2 (4%) 2 (4%)
Hemorrhage 1 (2%)
Inflammation, Chronic Active 4 (8%) 6 (12%)
Mucosa, Nasolacrimal Duct, Hyperplasia 1 (2%)
Nasolacrimal Duct, Dilatation 1 (2%)
Nasolacrimal Duct, Hyperkeratosis 1 (2%)
Nasolacrimal Duct, Inflammation, Suppurative 4 (8%) 5 (10%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (12) (8)
Hemorrhage 1 (8%)
Lens, Cataract 9 (75%) 5 (63%)
Retina, Atrophy 8 (67%) 5 (63%)
Harderian Gland (50) (50)
Inflammation, Chronic Active 1 (2%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50)
Cyst 1 (2%) 1 (2%)
Inflammation, Chronic Active 1 (2%)
Necrosis, Coagulative 1 (2%)
Nephropathy, Chronic 48 (96%) 47 (94%)
Urinary Bladder (49) (50)
Transitional Epithelium, Hyperplasia 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 05076-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ETHYLENETHIOUREA Date: 09/09/94
Route: DOSED FEED Time: 20:34:58
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 0 PPM 25 PPM 83 PPM 83 PPM 83 PPM
0-0 10-0 1-1 0-3 3-3 10-3
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50 50 50 50
Early Deaths
Natural Death 10 5 8 7 7 10
Moribund Sacrifice 21 27 20 26 23 25
Survivors
Terminal Sacrifice 18 15 17 15 18 14
Natural Death 1 1 3 1 1
Moribund Sacrifice 2 2 2 1
Animals Examined Microscopically 50 50 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (50) (50) (50) (50) (50) (50)
Hemorrhage 1 (2%)
Intestine Large, Cecum (45) (47) (40) (44) (43) (43)
Inflammation, Chronic Active 1 (2%) 1 (2%) 2 (5%) 1 (2%)
Parasite Metazoan 1 (3%) 1 (2%)
Perivascular, Inflammation, Chronic Active 5 (11%)
Intestine Large, Colon (48) (49) (42) (45) (45) (50)
Necrosis, Coagulative 1 (2%)
Parasite Metazoan 3 (6%) 1 (2%) 3 (7%) 3 (7%) 2 (4%) 3 (6%)
Intestine Large, Rectum (47) (46) (40) (43) (44) (45)
Edema 1 (2%)
Inflammation, Chronic Active 1 (2%)
Parasite Metazoan 7 (15%) 2 (4%) 3 (8%) 9 (21%) 5 (11%) 5 (11%)
Artery, Necrosis, Fibrinoid 1 (2%)
Perivascular, Inflammation, Chronic Active 1 (2%)
Intestine Small, Duodenum (48) (49) (46) (47) (49) (49)
Inflammation, Chronic Active 1 (2%) 1 (2%) 1 (2%)
Necrosis, Coagulative 1 (2%)
Intestine Small, Ileum (45) (47) (42) (43) (45) (46)
Edema 1 (2%)
Necrosis, Coagulative 1 (2%)
Intestine Small, Jejunum (48) (49) (44) (46) (47) (50)
Dilatation 1 (2%)
Edema 1 (2%)
Inflammation, Chronic Active 1 (2%) 1 (2%)
Metaplasia, Osseous 1 (2%)
Liver (50) (50) (50) (50) (50) (50)
Basophilic Focus 12 (24%) 4 (8%) 9 (18%) 7 (14%) 14 (28%) 5 (10%)
Clear Cell Focus 1 (2%) 2 (4%) 2 (4%) 2 (4%) 1 (2%)
Cyst 1 (2%)
Degeneration, Cystic 17 (34%) 19 (38%) 18 (36%) 13 (26%) 20 (40%) 21 (42%)
Eosinophilic Focus 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 12
NTP Experiment-Test: 05076-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ETHYLENETHIOUREA Date: 09/09/94
Route: DOSED FEED Time: 20:34:58
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 0 PPM 25 PPM 83 PPM 83 PPM 83 PPM
0-0 10-0 1-1 0-3 3-3 10-3
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Hematopoietic Cell Proliferation 1 (2%)
Hepatodiaphragmatic Nodule 1 (2%)
Hepatodiaphragmatic Nodule, Multiple 1 (2%)
Hyperplasia 1 (2%) 2 (4%)
Inflammation, Chronic 2 (4%) 3 (6%) 7 (14%) 3 (6%) 1 (2%) 1 (2%)
Leukocytosis 1 (2%) 1 (2%)
Necrosis, Coagulative 2 (4%) 4 (8%) 3 (6%) 4 (8%) 6 (12%)
Vacuolization Cytoplasmic 1 (2%) 1 (2%) 2 (4%) 2 (4%)
Bile Duct, Hyperplasia 4 (8%) 1 (2%) 1 (2%)
Mesentery (3) (5) (6) (2) (2) (3)
Hemorrhage 1 (17%)
Inflammation, Chronic Active 3 (100%) 2 (40%) 4 (67%) 1 (50%) 1 (50%) 1 (33%)
Thrombosis 1 (50%)
Pancreas (48) (50) (50) (50) (49) (50)
Cyst 1 (2%) 1 (2%) 1 (2%)
Inflammation, Chronic Active 1 (2%) 1 (2%)
Acinus, Atrophy 20 (42%) 30 (60%) 24 (48%) 24 (48%) 27 (55%) 18 (36%)
Acinus, Hyperplasia 1 (2%)
Acinus, Hyperplasia, Focal 1 (2%) 1 (2%)
Artery, Necrosis, Fibrinoid 1 (2%)
Perivascular, Inflammation, Chronic Active 1 (2%) 3 (6%) 1 (2%) 1 (2%) 5 (10%)
Salivary Glands (50) (49) (50) (50) (50) (50)
Inflammation, Chronic Active 1 (2%) 1 (2%)
Stomach, Forestomach (49) (50) (47) (50) (48) (49)
Acanthosis 4 (8%) 3 (6%) 2 (4%) 4 (8%) 3 (6%)
Hyperkeratosis 4 (8%) 3 (6%) 2 (4%) 4 (8%) 3 (6%)
Hyperplasia 1 (2%)
Hyperplasia, Squamous 1 (2%) 1 (2%)
Inflammation, Chronic Active 3 (6%) 4 (8%) 3 (6%) 5 (10%) 6 (13%) 3 (6%)
Stomach, Glandular (49) (50) (47) (49) (49) (49)
Cyst Epithelial Inclusion 1 (2%)
Inflammation, Chronic Active 1 (2%) 2 (4%) 3 (6%) 4 (8%) 6 (12%)
Mineralization 2 (4%) 4 (8%) 1 (2%) 2 (4%) 2 (4%) 3 (6%)
Necrosis, Coagulative 1 (2%) 1 (2%)
Tooth (50) (50) (49) (50) (50) (50)
Cyst 1 (2%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50) (50) (50) (50) (50)
Cardiomyopathy, Chronic 46 (92%) 44 (88%) 47 (94%) 41 (82%) 44 (88%) 47 (94%)
Inflammation, Chronic Active 1 (2%) 1 (2%) 1 (2%)
Mineralization 2 (4%) 1 (2%) 2 (4%) 1 (2%) 3 (6%)
Atrium, Thrombosis 3 (6%) 8 (16%) 1 (2%) 7 (14%) 1 (2%) 4 (8%)
Ventricle, Thrombosis 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 13
NTP Experiment-Test: 05076-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ETHYLENETHIOUREA Date: 09/09/94
Route: DOSED FEED Time: 20:34:58
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 0 PPM 25 PPM 83 PPM 83 PPM 83 PPM
0-0 10-0 1-1 0-3 3-3 10-3
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (50) (50) (49) (50) (49) (50)
Accessory Adrenal Cortical Nodule 1 (2%)
Degeneration, Fatty 14 (28%) 15 (30%) 11 (22%) 15 (30%) 13 (27%) 10 (20%)
Hyperplasia 15 (30%) 18 (36%) 19 (39%) 17 (34%) 21 (43%) 16 (32%)
Hypertrophy 4 (8%) 2 (4%) 5 (10%) 2 (4%) 5 (10%) 5 (10%)
Necrosis, Coagulative 1 (2%) 1 (2%)
Adrenal Gland, Medulla (50) (50) (49) (49) (49) (50)
Hematocyst 1 (2%)
Hyperplasia 21 (42%) 21 (42%) 23 (47%) 21 (43%) 30 (61%) 21 (42%)
Necrosis, Coagulative 1 (2%)
Islets, Pancreatic (48) (50) (50) (50) (49) (50)
Hyperplasia, Focal 1 (2%)
Parathyroid Gland (44) (46) (48) (45) (45) (47)
Hyperplasia 8 (18%) 5 (11%) 3 (6%) 4 (9%) 6 (13%) 5 (11%)
Pituitary Gland (50) (50) (48) (47) (49) (49)
Pars Distalis, Angiectasis 1 (2%)
Pars Distalis, Cyst 4 (8%) 3 (6%) 4 (8%) 4 (9%) 7 (14%) 3 (6%)
Pars Distalis, Hemorrhage 2 (4%) 4 (8%)
Pars Distalis, Hyperplasia 12 (24%) 9 (18%) 12 (25%) 9 (19%) 10 (20%) 12 (24%)
Pars Distalis, Vacuolization Cytoplasmic 1 (2%)
Pars Intermedia, Cyst 1 (2%) 2 (4%) 3 (6%) 4 (9%) 5 (10%) 4 (8%)
Rathke's Cleft, Cyst 1 (2%)
Thyroid Gland (49) (49) (46) (46) (47) (50)
Inflammation, Chronic Active 1 (2%)
Ultimobranchial Cyst 3 (6%)
C-Cell, Hyperplasia 29 (59%) 33 (67%) 22 (48%) 30 (65%) 35 (74%) 27 (54%)
Follicle, Cyst 1 (2%)
Follicular Cell, Hyperplasia 4 (8%) 12 (24%) 13 (28%) 30 (65%) 35 (74%) 47 (94%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Coagulating Gland (3)
Inflammation, Chronic Active 2 (67%)
Epididymis (50) (50) (50) (50) (49) (50)
Inflammation, Chronic Active 1 (2%) 1 (2%)
Perivascular, Inflammation, Chronic Active 1 (2%)
Preputial Gland (49) (49) (49) (49) (46) (50)
Hyperplasia 3 (6%) 1 (2%) 1 (2%) 1 (2%) 2 (4%)
Hypertrophy 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 14
NTP Experiment-Test: 05076-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ETHYLENETHIOUREA Date: 09/09/94
Route: DOSED FEED Time: 20:34:58
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 0 PPM 25 PPM 83 PPM 83 PPM 83 PPM
0-0 10-0 1-1 0-3 3-3 10-3
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Inflammation, Chronic 1 (2%)
Inflammation, Chronic Active 45 (92%) 45 (92%) 46 (94%) 46 (94%) 42 (91%) 47 (94%)
Duct, Dilatation 1 (2%) 1 (2%) 1 (2%)
Prostate (50) (50) (50) (50) (50) (49)
Cyst 1 (2%) 3 (6%) 1 (2%)
Inflammation, Chronic Active 29 (58%) 27 (54%) 23 (46%) 24 (48%) 21 (42%) 25 (51%)
Epithelium, Hyperplasia 1 (2%) 2 (4%)
Seminal Vesicle (1) (1) (4) (1)
Inflammation, Chronic Active 1 (25%) 1 (100%)
Testes (50) (50) (50) (50) (50) (50)
Cyst 1 (2%)
Inflammation, Chronic Active 1 (2%)
Necrosis, Coagulative 1 (2%) 1 (2%)
Interstitial Cell, Hyperplasia 9 (18%) 12 (24%) 9 (18%) 7 (14%) 4 (8%) 5 (10%)
Seminiferous Tubule, Atrophy 9 (18%) 8 (16%) 11 (22%) 11 (22%) 8 (16%) 6 (12%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50) (50) (49) (50)
Femoral, Hyperplasia, Reticulum Cell 1 (2%) 1 (2%)
Femoral, Myelofibrosis 1 (2%) 1 (2%) 1 (2%) 1 (2%)
Femoral, Myeloid Cell, Atrophy 1 (2%)
Femoral, Myeloid Cell, Hyperplasia 1 (2%)
Lymph Node (50) (50) (50) (50) (48) (50)
Inguinal, Necrosis 1 (2%)
Mandibular, Cyst 1 (2%) 2 (4%) 1 (2%) 3 (6%) 2 (4%)
Mandibular, Hyperplasia, Lymphoid 1 (2%) 1 (2%)
Mandibular, Hyperplasia, Plasma Cell 2 (4%) 1 (2%) 1 (2%)
Mandibular, Necrosis 1 (2%) 1 (2%)
Mediastinal, Cyst 2 (4%) 1 (2%)
Mediastinal, Inflammation, Chronic Active 1 (2%)
Mediastinal, Inflammation, Suppurative 1 (2%)
Renal, Infiltration Cellular, Histiocyte 1 (2%)
Lymph Node, Mesenteric (2) (10) (14) (10) (9) (10)
Cyst 1 (10%)
Necrosis 1 (10%)
Spleen (50) (50) (50) (50) (50) (50)
Fibrosis 6 (12%) 8 (16%) 2 (4%) 4 (8%) 3 (6%) 4 (8%)
Hematopoietic Cell Proliferation 1 (2%) 3 (6%) 1 (2%) 1 (2%) 2 (4%)
Necrosis, Coagulative 2 (4%) 1 (2%) 1 (2%) 1 (2%)
Thrombosis 1 (2%) 2 (4%)
Thymus (40) (39) (45) (42) (40) (38)
Cyst 1 (2%)
Ectopic Parathyroid Gland 1 (3%)
Necrosis 1 (3%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 15
NTP Experiment-Test: 05076-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ETHYLENETHIOUREA Date: 09/09/94
Route: DOSED FEED Time: 20:34:58
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 0 PPM 25 PPM 83 PPM 83 PPM 83 PPM
0-0 10-0 1-1 0-3 3-3 10-3
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (42) (40) (42) (37) (45) (41)
Hyperplasia, Cystic 42 (100%) 36 (90%) 39 (93%) 35 (95%) 40 (89%) 37 (90%)
Skin (50) (49) (50) (50) (49) (50)
Abscess 1 (2%)
Acanthosis 1 (2%) 1 (2%)
Cyst Epithelial Inclusion 1 (2%) 1 (2%)
Hyperkeratosis 1 (2%)
Hyperplasia, Basal Cell 1 (2%)
Inflammation, Chronic Active 1 (2%) 2 (4%) 1 (2%)
Subcutaneous Tissue, Fibrosis 1 (2%)
Vein, Dilatation 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50) (50) (50)
Cranium, Fibrous Osteodystrophy 4 (8%) 4 (8%) 3 (6%) 1 (2%) 6 (12%) 3 (6%)
Femur, Fibrous Osteodystrophy 4 (8%) 4 (8%) 3 (6%) 1 (2%) 6 (12%) 3 (6%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50) (50) (50) (50) (50)
Compression 5 (10%) 5 (10%) 1 (2%) 5 (10%) 3 (6%)
Hemorrhage 1 (2%) 2 (4%) 1 (2%) 3 (6%) 3 (6%) 1 (2%)
Hydrocephalus 4 (8%) 5 (10%) 2 (4%) 5 (10%) 3 (6%)
Necrosis 1 (2%) 1 (2%)
Peripheral Nerve (2) (1) (1)
Sciatic, Degeneration 1 (100%)
Spinal Cord (2) (1) (2)
Hemorrhage 1 (50%)
White Matter, Degeneration 2 (100%) 1 (100%) 1 (50%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50) (50) (50) (50)
Granuloma 1 (2%)
Hemorrhage 1 (2%) 1 (2%)
Inflammation, Chronic Active 9 (18%) 4 (8%) 5 (10%) 5 (10%) 5 (10%) 3 (6%)
Leukocytosis 1 (2%)
Metaplasia, Osseous 1 (2%) 1 (2%)
Mineralization 1 (2%)
Necrosis, Coagulative 1 (2%)
Alveolar Epithelium, Hyperplasia 1 (2%) 1 (2%) 2 (4%) 2 (4%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 16
NTP Experiment-Test: 05076-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ETHYLENETHIOUREA Date: 09/09/94
Route: DOSED FEED Time: 20:34:58
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 0 PPM 25 PPM 83 PPM 83 PPM 83 PPM
0-0 10-0 1-1 0-3 3-3 10-3
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM - CONT
Artery, Mediastinum, Necrosis, Fibrinoid 1 (2%)
Mediastinum, Mineralization 1 (2%)
Mediastinum, Perivascular, Inflammation,
Chronic Active 1 (2%) 1 (2%)
Nose (50) (50) (50) (50) (49) (50)
Cyst 1 (2%)
Fungus 5 (10%) 1 (2%) 5 (10%) 1 (2%)
Hemorrhage 1 (2%)
Inflammation, Chronic Active 15 (30%) 10 (20%) 12 (24%) 11 (22%) 13 (27%) 13 (26%)
Nasolacrimal Duct, Hyperkeratosis 1 (2%)
Nasolacrimal Duct, Inflammation, Suppurative 6 (12%) 4 (8%) 7 (14%) 5 (10%) 8 (16%) 5 (10%)
Trachea (50) (50) (50) (50) (50) (50)
Cyst 1 (2%)
Hemorrhage 1 (2%)
Inflammation, Chronic Active 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (11) (10) (6) (8) (4) (5)
Hemorrhage 1 (9%) 1 (20%)
Inflammation, Chronic Active 1 (9%) 1 (20%)
Lens, Cataract 9 (82%) 7 (70%) 4 (67%) 6 (75%) 3 (75%) 3 (60%)
Retina, Atrophy 10 (91%) 9 (90%) 4 (67%) 6 (75%) 3 (75%) 3 (60%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (49) (50) (50) (50)
Bacterium 1 (2%)
Hydronephrosis 1 (2%)
Infarct 1 (2%)
Infiltration Cellular, Mixed Cell 1 (2%)
Inflammation, Chronic Active 1 (2%) 1 (2%)
Necrosis, Coagulative 2 (4%)
Nephropathy, Chronic 49 (98%) 50 (100%) 47 (96%) 49 (98%) 49 (98%) 50 (100%)
Artery, Necrosis, Fibrinoid 1 (2%)
Perivascular, Inflammation, Chronic Active 1 (2%)
Renal Tubule, Hyperplasia 1 (2%)
Renal Tubule, Mineralization 1 (2%)
Renal Tubule, Epithelium, Hyperplasia 3 (6%) 1 (2%) 3 (6%)
Urethra (1)
Transitional Epithelium, Hyperplasia 1 (100%)
Urinary Bladder (49) (50) (48) (49) (48) (50)
Dilatation 1 (2%)
Hemorrhage 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 17
NTP Experiment-Test: 05076-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ETHYLENETHIOUREA Date: 09/09/94
Route: DOSED FEED Time: 20:34:58
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 PPM 0 PPM 25 PPM 83 PPM 83 PPM 83 PPM
0-0 10-0 1-1 0-3 3-3 10-3
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Inflammation, Chronic Active 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 18
NTP Experiment-Test: 05076-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ETHYLENETHIOUREA Date: 09/09/94
Route: DOSED FEED Time: 20:34:58
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 250 PPM 250 PPM
0-10 10-10
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50
Early Deaths
Moribund Sacrifice 23 30
Natural Death 8 14
Accidently Killed 5
Survivors
Moribund Sacrifice 1
Natural Death 1
Terminal Sacrifice 14 4
Animals Examined Microscopically 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (50) (50)
Inflammation, Chronic Active 1 (2%)
Intestine Large, Cecum (44) (39)
Artery, Inflammation, Chronic Active 1 (3%)
Intestine Large, Colon (47) (47)
Parasite Metazoan 2 (4%) 3 (6%)
Intestine Large, Rectum (43) (45)
Parasite Metazoan 4 (9%) 3 (7%)
Artery, Inflammation, Chronic Active 1 (2%)
Intestine Small, Duodenum (50) (49)
Inflammation, Chronic Active 1 (2%)
Necrosis, Coagulative 1 (2%)
Liver (50) (50)
Angiectasis 2 (4%) 2 (4%)
Basophilic Focus 15 (30%) 3 (6%)
Clear Cell Focus 4 (8%)
Degeneration, Cystic 25 (50%) 17 (34%)
Inflammation, Chronic 10 (20%) 3 (6%)
Leukocytosis 1 (2%)
Necrosis, Coagulative 6 (12%) 4 (8%)
Thrombosis 1 (2%)
Vacuolization Cytoplasmic 2 (4%) 1 (2%)
Mesentery (2) (3)
Inflammation, Chronic Active 2 (100%)
Artery, Inflammation, Chronic Active 1 (33%)
Pancreas (49) (50)
Necrosis, Coagulative 1 (2%)
Acinus, Atrophy 17 (35%) 19 (38%)
Artery, Inflammation, Chronic Active 1 (2%)
Salivary Glands (50) (49)
Inflammation, Chronic Active 2 (4%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 19
NTP Experiment-Test: 05076-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ETHYLENETHIOUREA Date: 09/09/94
Route: DOSED FEED Time: 20:34:58
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 250 PPM 250 PPM
0-10 10-10
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Necrosis 1 (2%)
Artery, Inflammation, Chronic Active 1 (2%)
Stomach, Forestomach (49) (50)
Necrosis, Coagulative 3 (6%)
Stomach, Glandular (49) (49)
Inflammation, Chronic Active 2 (4%)
Mineralization 1 (2%) 2 (4%)
Artery, Inflammation, Chronic Active 1 (2%)
Tooth (49) (50)
Inflammation, Chronic Active 1 (2%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (50) (50)
Cardiomyopathy, Chronic 39 (78%) 43 (86%)
Mineralization 1 (2%)
Artery, Inflammation, Chronic Active 1 (2%)
Atrium, Thrombosis 3 (6%) 4 (8%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (50) (50)
Degeneration, Fatty 14 (28%) 13 (26%)
Hyperplasia 9 (18%) 6 (12%)
Hypertrophy, Focal 1 (2%)
Necrosis, Coagulative 1 (2%)
Vacuolization Cytoplasmic 1 (2%)
Adrenal Gland, Medulla (50) (50)
Hyperplasia 14 (28%) 17 (34%)
Necrosis, Coagulative 1 (2%)
Islets, Pancreatic (50) (50)
Hyperplasia 3 (6%)
Necrosis, Coagulative 1 (2%)
Pituitary Gland (50) (49)
Pars Distalis, Atypia Cellular 1 (2%)
Pars Distalis, Cyst 8 (16%)
Pars Distalis, Hyperplasia 6 (12%) 16 (33%)
Pars Distalis, Vacuolization Cytoplasmic 1 (2%)
Thyroid Gland (50) (50)
Inflammation, Chronic Active 1 (2%)
Artery, Inflammation, Chronic Active 1 (2%)
C-Cell, Hyperplasia 12 (24%) 9 (18%)
Follicular Cell, Hyperplasia 41 (82%) 39 (78%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 20
NTP Experiment-Test: 05076-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ETHYLENETHIOUREA Date: 09/09/94
Route: DOSED FEED Time: 20:34:58
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 250 PPM 250 PPM
0-10 10-10
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (49) (50)
Mineralization 1 (2%)
Preputial Gland (49) (50)
Inflammation, Chronic Active 41 (84%) 42 (84%)
Prostate (49) (50)
Cyst 2 (4%) 1 (2%)
Inflammation, Chronic Active 27 (55%) 27 (54%)
Seminal Vesicle (2)
Artery, Inflammation, Chronic Active 1 (50%)
Testes (50) (50)
Artery, Inflammation, Chronic Active 1 (2%)
Interstitial Cell, Hyperplasia 6 (12%) 8 (16%)
Seminiferous Tubule, Atrophy 8 (16%) 7 (14%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (49) (50)
Femoral, Myelofibrosis 1 (2%)
Lymph Node (50) (49)
Mandibular, Hyperplasia, Plasma Cell 2 (4%) 3 (6%)
Lymph Node, Mesenteric (14) (10)
Cyst 1 (7%)
Spleen (50) (50)
Fibrosis 8 (16%) 6 (12%)
Hematopoietic Cell Proliferation 1 (2%)
Necrosis, Coagulative 2 (4%)
Artery, Inflammation, Chronic Active 1 (2%)
Thymus (43) (44)
Ectopic Parathyroid Gland 1 (2%)
Hemorrhage 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (36) (37)
Hyperplasia, Cystic 31 (86%) 37 (100%)
Skin (49) (49)
Hyperkeratosis 1 (2%)
Inflammation, Chronic Active 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 21
NTP Experiment-Test: 05076-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ETHYLENETHIOUREA Date: 09/09/94
Route: DOSED FEED Time: 20:34:58
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 250 PPM 250 PPM
0-10 10-10
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (49) (50)
Femur, Fibrous Osteodystrophy 1 (2%)
Skeletal Muscle (5) (2)
Artery, Inflammation, Chronic Active 1 (50%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (50)
Compression 1 (2%)
Hemorrhage 1 (2%)
Hydrocephalus 1 (2%)
Artery, Inflammation, Chronic Active 1 (2%)
Peripheral Nerve (6)
Sciatic, Degeneration 2 (33%)
Spinal Cord (7)
White Matter, Degeneration 2 (29%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50)
Congestion 1 (2%)
Hemorrhage 1 (2%)
Inflammation, Chronic Active 6 (12%) 10 (20%)
Thrombosis 1 (2%) 1 (2%)
Artery, Mediastinum, Inflammation, Chronic
Active 1 (2%)
Vein, Mediastinum, Thrombosis 1 (2%)
Nose (50) (50)
Foreign Body 1 (2%)
Fungus 1 (2%) 5 (10%)
Hemorrhage 3 (6%)
Inflammation, Chronic Active 9 (18%) 16 (32%)
Nasolacrimal Duct, Foreign Body 1 (2%)
Nasolacrimal Duct, Inflammation, Suppurative 7 (14%) 6 (12%)
Trachea (50) (50)
Inflammation, Chronic Active 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 22
NTP Experiment-Test: 05076-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC ETHYLENETHIOUREA Date: 09/09/94
Route: DOSED FEED Time: 20:34:58
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 250 PPM 250 PPM
0-10 10-10
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (11) (10)
Lens, Cataract 5 (45%) 9 (90%)
Retina, Atrophy 5 (45%) 8 (80%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50)
Necrosis, Coagulative 1 (2%) 1 (2%)
Nephropathy, Chronic 45 (90%) 50 (100%)
Artery, Inflammation, Chronic Active 1 (2%)
Renal Tubule, Epithelium, Hyperplasia 7 (14%) 2 (4%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 23
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