National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/2431

TR 388 Rat Pathology Tables


                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                          ETHYLENETHIOUREA


NTP Experiment-Test: 05076-01                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 09/09/94
Route: DOSED FEED                                                                                                 Time: 20:35:00




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  96-45-7

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05076-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 09/09/94  
Route: DOSED FEED                                                                                                 Time: 20:35:00  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 PPM        0 PPM        25 PPM       83 PPM       83 PPM       83 PPM          
                                                   0-0          10-0         1-1           0-3          3-3          10-3           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           50           50           50           50           50           
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                20           15           13            8           10           13           
    Natural Death                                      6            5            3            9           13            4           
  Survivors                                                                                                                         
    Moribund Sacrifice                                                                        2            1                        
    Terminal Sacrifice                                23           30           34           30           26           32           
    Natural Death                                      1                                      1                         1           
  Animals Examined Microscopically                    50           50           50           50           50           50           
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (50)         (50)         (49)         (50)         (49)         (50)         
   Intestine Large, Colon                             (47)         (47)         (50)         (45)         (43)         (47)         
   Intestine Small, Duodenum                          (49)         (49)         (50)         (48)         (48)         (49)         
   Intestine Small, Ileum                             (45)         (47)         (48)         (42)         (42)         (44)         
      Jejunum, Sarcoma Stromal, Metastatic                          1 (2%)                                                          
   Intestine Small, Jejunum                           (47)         (47)         (50)         (44)         (45)         (48)         
      Leiomyoma                                                                                            1 (2%)                   
   Liver                                              (50)         (50)         (50)         (50)         (50)         (50)         
      Adenocarcinoma, Metastatic, Uterus               1 (2%)                                                                       
      Hepatocellular Adenoma                                        1 (2%)                    1 (2%)       1 (2%)                   
      Histiocytic Sarcoma                                           1 (2%)                                                          
      Neoplastic Nodule                                             1 (2%)                                                          
   Mesentery                                          (3)          (2)          (2)          (1)          (4)          (8)          
      Adenocarcinoma, Metastatic, Uterus               1 (33%)                                                                      
      Sarcoma Stromal, Metastatic, Uterus                           1 (50%)                                                         
   Pancreas                                           (50)         (49)         (50)         (49)         (49)         (50)         
      Adenocarcinoma, Metastatic, Uterus               1 (2%)                                                                       
   Salivary Glands                                    (50)         (50)         (50)         (50)         (50)         (49)         
   Stomach, Forestomach                               (49)         (49)         (50)         (49)         (48)         (50)         
      Glandular, Adenocarcinoma, Metastatic, Uterus    1 (2%)                                                                       
   Stomach, Glandular                                 (48)         (49)         (50)         (48)         (48)         (50)         
   Tongue                                             (1)                       (1)          (1)          (1)          (1)          
      Squamous Cell Carcinoma                                                    1 (100%)                                           
      Squamous Cell Papilloma                          1 (100%)                               1 (100%)     1 (100%)     1 (100%)    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   2                                                               
NTP Experiment-Test: 05076-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 09/09/94  
Route: DOSED FEED                                                                                                 Time: 20:35:00  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 PPM        0 PPM        25 PPM       83 PPM       83 PPM       83 PPM          
                                                   0-0          10-0         1-1           0-3          3-3          10-3           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)         (50)         (50)         (50)         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (49)         (49)         (48)         (49)         (50)         
      Adenoma                                          2 (4%)       1 (2%)       6 (12%)                                2 (4%)      
      Capsule, Adenocarcinoma, Metastatic, Uterus      1 (2%)                                                                       
   Adrenal Gland, Medulla                             (50)         (49)         (49)         (49)         (49)         (50)         
      Pheochromocytoma Malignant                                                              2 (4%)                                
      Pheochromocytoma Benign                          2 (4%)       8 (16%)      1 (2%)       1 (2%)       5 (10%)      7 (14%)     
      Bilateral, Pheochromocytoma Benign                                         2 (4%)       1 (2%)       1 (2%)       3 (6%)      
   Islets, Pancreatic                                 (50)         (49)         (50)         (50)         (50)         (50)         
      Adenoma                                                                    1 (2%)       1 (2%)                                
      Carcinoma                                                                                            1 (2%)                   
   Parathyroid Gland                                  (46)         (47)         (48)         (46)         (46)         (47)         
      Adenoma                                                       1 (2%)       2 (4%)                    1 (2%)       1 (2%)      
   Pituitary Gland                                    (50)         (50)         (49)         (49)         (49)         (49)         
      Pars Distalis, Adenoma                          24 (48%)     23 (46%)     26 (53%)     25 (51%)     20 (41%)     25 (51%)     
      Pars Distalis, Adenoma, Multiple                                           1 (2%)                                 1 (2%)      
      Pars Distalis, Carcinoma                                                   1 (2%)       1 (2%)                    1 (2%)      
   Thyroid Gland                                      (50)         (48)         (49)         (44)         (46)         (47)         
      Bilateral, C-Cell, Adenoma                                                 3 (6%)                    2 (4%)                   
      Bilateral, Follicular Cell, Adenoma, Multiple                                           1 (2%)                                
      C-Cell, Adenoma                                 11 (22%)     10 (21%)     14 (29%)     12 (27%)      6 (13%)      6 (13%)     
      C-Cell, Carcinoma                                1 (2%)       3 (6%)       1 (2%)                    1 (2%)       2 (4%)      
      Follicular Cell, Adenocarcinoma                  2 (4%)                    1 (2%)       1 (2%)       1 (2%)       2 (4%)      
      Follicular Cell, Adenoma                         1 (2%)                                 5 (11%)      5 (11%)      7 (15%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (48)         (50)         (49)         (47)         (49)         (45)         
      Adenoma                                          3 (6%)       1 (2%)                    2 (4%)       1 (2%)                   
      Carcinoma                                                     1 (2%)                    1 (2%)                    1 (2%)      
   Ovary                                              (50)         (50)         (50)         (50)         (50)         (50)         
      Adenocarcinoma, Metastatic, Uterus               1 (2%)                                                                       
      Cystadenoma                                                                                                       1 (2%)      
      Granulosa-Theca Tumor Malignant                                                         1 (2%)                                
   Uterus                                             (50)         (50)         (50)         (50)         (50)         (50)         
      Adenocarcinoma                                   1 (2%)                                                                       
                                                             Page   3                                                               
NTP Experiment-Test: 05076-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 09/09/94  
Route: DOSED FEED                                                                                                 Time: 20:35:00  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 PPM        0 PPM        25 PPM       83 PPM       83 PPM       83 PPM          
                                                   0-0          10-0         1-1           0-3          3-3          10-3           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - cont                                                                                                               
      Leiomyoma                                        1 (2%)                    1 (2%)       1 (2%)                                
      Polyp Stromal                                    8 (16%)      6 (12%)     13 (26%)     15 (30%)      7 (14%)      6 (12%)     
      Polyp Stromal, Multiple                          1 (2%)                                                                       
      Sarcoma Stromal                                               1 (2%)                                 1 (2%)                   
      Cervix, Squamous Cell Carcinoma                               1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Blood                                              (10)         (10)         (16)         (14)         (18)         (11)         
   Bone Marrow                                        (50)         (50)         (49)         (50)         (47)         (50)         
   Lymph Node                                         (50)         (49)         (50)         (50)         (50)         (50)         
      Deep Cervical, Carcinoma, Metastatic,                                                                                         
          Thyroid Gland                                             1 (2%)                                                          
   Lymph Node, Mesenteric                             (5)          (8)          (6)          (14)         (14)         (6)          
   Spleen                                             (50)         (50)         (50)         (50)         (50)         (50)         
      Adenocarcinoma, Metastatic, Uterus               1 (2%)                                                                       
      Fibrosarcoma                                                                                                      2 (4%)      
      Hemangiosarcoma                                                                         1 (2%)                                
   Thymus                                             (43)         (46)         (44)         (44)         (45)         (42)         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (47)         (50)         (50)         (50)         (50)         
      Adenocarcinoma                                                             1 (2%)       1 (2%)       2 (4%)                   
      Adenoma                                                       1 (2%)       1 (2%)                                 2 (4%)      
      Fibroadenoma                                    10 (20%)     11 (23%)      7 (14%)     11 (22%)     11 (22%)      9 (18%)     
      Fibroadenoma, Multiple                           3 (6%)       2 (4%)       1 (2%)       2 (4%)                                
      Mixed Tumor Malignant                                                                                             1 (2%)      
   Skin                                               (50)         (49)         (50)         (50)         (50)         (48)         
      Basal Cell Adenoma                                            1 (2%)                                                          
      Basal Cell Carcinoma                                          1 (2%)                                                          
      Keratoacanthoma                                  1 (2%)                    1 (2%)                                             
      Squamous Cell Carcinoma                                                                              1 (2%)                   
      Subcutaneous Tissue, Fibroma                                                                         1 (2%)       1 (2%)      
      Subcutaneous Tissue, Fibrosarcoma                1 (2%)                                                           1 (2%)      
      Subcutaneous Tissue, Lip, Osteosarcoma,                                                                                       
          Metastatic, Bone                             1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (49)         (50)         (50)         (50)         (50)         
      Chondrosarcoma                                                             2 (4%)                                             
      Mandible, Osteosarcoma                           1 (2%)                                                                       
   Skeletal Muscle                                                 (1)                                                              
                                                             Page   4                                                               
NTP Experiment-Test: 05076-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 09/09/94  
Route: DOSED FEED                                                                                                 Time: 20:35:00  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 PPM        0 PPM        25 PPM       83 PPM       83 PPM       83 PPM          
                                                   0-0          10-0         1-1           0-3          3-3          10-3           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
MUSCULOSKELETAL SYSTEM - cont                                                                                                       
      Diaphragm, Sarcoma Stromal, Metastatic,                                                                                       
          Uterus                                                    1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)         (50)         (50)         
      Astrocytoma Malignant                            1 (2%)                    1 (2%)                                             
      Carcinoma, Metastatic, Pituitary Gland                                     1 (2%)                                 1 (2%)      
      Meningioma Benign                                                                                    1 (2%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)         (50)         (50)         
      Adenocarcinoma, Metastatic, Uterus               1 (2%)                                                                       
      Alveolar/Bronchiolar Carcinoma                                                                                    1 (2%)      
      Carcinoma, Metastatic, Thyroid Gland                                                                 1 (2%)                   
      Chordoma, Metastatic, Uncertain Primary Site     1 (2%)                                 1 (2%)                                
      Histiocytic Sarcoma                                           1 (2%)                                                          
      Mixed Tumor Malignant, Metastatic, Mammary                                                                                    
          Gland                                                                                                         1 (2%)      
      Pheochromocytoma Malignant, Metastatic,                                                                                       
          Adrenal Gland                                                                       1 (2%)                                
   Nose                                               (50)         (50)         (49)         (50)         (49)         (50)         
   Trachea                                            (50)         (50)         (49)         (50)         (50)         (50)         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                                                       (1)                                    
      Fibrosarcoma                                                                            1 (100%)                              
   Harderian Gland                                    (50)         (50)         (50)         (50)         (50)         (50)         
   Zymbal's Gland                                     (1)                                                              (3)          
      Adenoma                                                                                                           2 (67%)     
      Carcinoma                                        1 (100%)                                                         1 (33%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (49)         (50)         (50)         (50)         (50)         
      Adenocarcinoma, Metastatic, Uterus               1 (2%)                                                                       
      Lipoma                                                        1 (2%)                                                          
      Mixed Tumor Benign                                                                      1 (2%)                                
      Renal Tubule, Adenoma                                                                   1 (2%)       1 (2%)                   
   Urinary Bladder                                    (49)         (48)         (50)         (47)         (48)         (50)         
      Adenocarcinoma, Metastatic, Uterus               1 (2%)                                                                       
                                                             Page   5                                                               
NTP Experiment-Test: 05076-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 09/09/94  
Route: DOSED FEED                                                                                                 Time: 20:35:00  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 PPM        0 PPM        25 PPM       83 PPM       83 PPM       83 PPM          
                                                   0-0          10-0         1-1           0-3          3-3          10-3           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - cont                                                                                                               
      Hemangioma                                                    1 (2%)                                                          
      Sarcoma Stromal, Metastatic, Uterus                           1 (2%)                                                          
      Transitional Epithelium, Carcinoma                                                                   1 (2%)                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)        *(50)        *(50)        *(50)         
      Histiocytic Sarcoma                                           1 (2%)                                                          
      Leukemia Mononuclear                            18 (36%)     18 (36%)     19 (38%)     22 (44%)     29 (58%)     23 (46%)     
      Mesothelioma Malignant                           1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   6                                                               
NTP Experiment-Test: 05076-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 09/09/94  
Route: DOSED FEED                                                                                                 Time: 20:35:00  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 PPM        0 PPM        25 PPM       83 PPM       83 PPM       83 PPM          
                                                   0-0          10-0         1-1           0-3          3-3          10-3           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            48          46          46          46          46          47               
     Total Primary Neoplasms                           95          95         107         112         102         109               
                                                                                                                                    
   Total Animals with Benign Neoplasms                 40          38          39          39          40          38               
     Total Benign Neoplasms                            68          69          80          81          65          74               
                                                                                                                                    
   Total Animals with Malignant Neoplasms              25          23          24          28          35          30               
     Total Malignant Neoplasms                         27          26          27          31          37          35               
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              3           2           1           2           1           2               
     Total Metastatic Neoplasm                         12           5           1           2           1           2               
                                                                                                                                    
   Total Animals with Malignant Neoplasms               1                                   1                                       
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   7                                                               
NTP Experiment-Test: 05076-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 09/09/94  
Route: DOSED FEED                                                                                                 Time: 20:35:00  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   250 PPM      250 PPM                                                             
                                                     0-10         10-10                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           50                                                               
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                26           30                                                               
    Natural Death                                      4            6                                                               
  Survivors                                                                                                                         
    Terminal Sacrifice                                20           13                                                               
    Natural Death                                                   1                                                               
  Animals Examined Microscopically                    50           50                                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Rectum                            (45)         (49)                                                             
      Polyp Adenomatous                                             1 (2%)                                                          
   Intestine Small, Ileum                             (45)         (50)                                                             
   Liver                                              (50)         (50)                                                             
      Hepatocellular Carcinoma                                      1 (2%)                                                          
   Pancreas                                           (49)         (50)                                                             
   Salivary Glands                                    (50)         (50)                                                             
   Stomach, Forestomach                               (50)         (50)                                                             
   Stomach, Glandular                                 (50)         (50)                                                             
   Tongue                                             (1)                                                                           
      Squamous Cell Papilloma                          1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (49)                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (50)                                                             
      Adenoma                                          1 (2%)       1 (2%)                                                          
      Carcinoma                                        1 (2%)                                                                       
   Adrenal Gland, Medulla                             (50)         (50)                                                             
      Pheochromocytoma Benign                          6 (12%)      4 (8%)                                                          
      Bilateral, Pheochromocytoma Benign                            1 (2%)                                                          
   Pituitary Gland                                    (50)         (50)                                                             
      Pars Distalis, Adenoma                          18 (36%)     24 (48%)                                                         
      Pars Distalis, Carcinoma                         3 (6%)       2 (4%)                                                          
      Pars Intermedia, Adenoma                         1 (2%)                                                                       
   Thyroid Gland                                      (49)         (50)                                                             
      Bilateral, C-Cell, Adenoma                       1 (2%)       2 (4%)                                                          
                                                             Page   8                                                               
NTP Experiment-Test: 05076-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 09/09/94  
Route: DOSED FEED                                                                                                 Time: 20:35:00  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   250 PPM      250 PPM                                                             
                                                     0-10         10-10                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - cont                                                                                                             
      Bilateral, Follicular Cell, Adenocarcinoma       1 (2%)       4 (8%)                                                          
      Bilateral, Follicular Cell, Adenoma              6 (12%)      9 (18%)                                                         
      Bilateral, Follicular Cell, Adenoma, Multiple    7 (14%)      2 (4%)                                                          
      C-Cell, Adenoma                                  9 (18%)      6 (12%)                                                         
      C-Cell, Carcinoma                                1 (2%)                                                                       
      Follicular Cell, Adenocarcinoma                  7 (14%)     13 (26%)                                                         
      Follicular Cell, Adenoma                        12 (24%)     11 (22%)                                                         
      Follicular Cell, Adenoma, Multiple               3 (6%)       7 (14%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (47)         (47)                                                             
      Adenoma                                          2 (4%)       2 (4%)                                                          
   Ovary                                              (50)         (50)                                                             
      Granulosa-Theca Tumor Benign                     1 (2%)                                                                       
   Uterus                                             (50)         (50)                                                             
      Polyp Stromal                                    7 (14%)      3 (6%)                                                          
      Sarcoma Stromal                                               1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Blood                                              (22)         (17)                                                             
   Bone Marrow                                        (49)         (50)                                                             
   Lymph Node                                         (50)         (50)                                                             
   Lymph Node, Mesenteric                             (3)          (8)                                                              
   Spleen                                             (50)         (50)                                                             
   Thymus                                             (41)         (44)                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (50)                                                             
      Adenocarcinoma                                   2 (4%)       2 (4%)                                                          
      Fibroadenoma                                     7 (14%)      9 (18%)                                                         
      Fibroadenoma, Multiple                           1 (2%)                                                                       
   Skin                                               (49)         (50)                                                             
      Subcutaneous Tissue, Fibroma                                  1 (2%)                                                          
      Subcutaneous Tissue, Fibrosarcoma                1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   9                                                               
NTP Experiment-Test: 05076-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 09/09/94  
Route: DOSED FEED                                                                                                 Time: 20:35:00  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   250 PPM      250 PPM                                                             
                                                     0-10         10-10                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                                 (1)                                                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)                                                             
      Carcinoma, Metastatic, Pituitary Gland           3 (6%)       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)                                                             
      Carcinoma, Metastatic                                         1 (2%)                                                          
   Nose                                               (50)         (50)                                                             
      Nasolacrimal Duct, Squamous Cell Papilloma                    1 (2%)                                                          
   Trachea                                            (50)         (50)                                                             
      Adenocarcinoma, Metastatic, Thyroid Gland                     1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                (1)          (1)                                                              
      Squamous Cell Papilloma                          1 (100%)                                                                     
   Eye                                                (12)         (8)                                                              
   Harderian Gland                                    (50)         (50)                                                             
   Zymbal's Gland                                     (2)          (4)                                                              
      Carcinoma                                        2 (100%)     4 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)                                                             
   Urinary Bladder                                    (49)         (50)                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)                                                             
      Leukemia Mononuclear                            27 (54%)     25 (50%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  10                                                               
NTP Experiment-Test: 05076-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 09/09/94  
Route: DOSED FEED                                                                                                 Time: 20:35:00  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   250 PPM      250 PPM                                                             
                                                     0-10         10-10                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            49          50                                                               
     Total Primary Neoplasms                          129         136                                                               
                                                                                                                                    
   Total Animals with Benign Neoplasms                 44          42                                                               
     Total Benign Neoplasms                            84          84                                                               
                                                                                                                                    
   Total Animals with Malignant Neoplasms              35          41                                                               
     Total Malignant Neoplasms                         45          52                                                               
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              3           3                                                               
     Total Metastatic Neoplasm                          3           3                                                               
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  11                                                               
NTP Experiment-Test: 05076-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 09/09/94  
Route: DOSED FEED                                                                                                 Time: 20:35:00  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 PPM        0 PPM        25 PPM       83 PPM       83 PPM       83 PPM          
                                                   0-0          10-0          1-1          0-3          3-3          10-3           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           50           50           50           50           50           
  Early Deaths                                                                                                                      
    Natural Death                                     10            5            8            7            7           10           
    Moribund Sacrifice                                21           27           20           26           23           25           
  Survivors                                                                                                                         
    Terminal Sacrifice                                18           15           17           15           18           14           
    Natural Death                                      1            1            3                         1            1           
    Moribund Sacrifice                                              2            2            2            1                        
  Animals Examined Microscopically                    50           50           50           50           50           50           
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (45)         (47)         (40)         (44)         (43)         (43)         
   Intestine Large, Colon                             (48)         (49)         (42)         (45)         (45)         (50)         
      Polyp Adenomatous                                                          1 (2%)                                             
   Intestine Large, Rectum                            (47)         (46)         (40)         (43)         (44)         (45)         
   Intestine Small, Duodenum                          (48)         (49)         (46)         (47)         (49)         (49)         
   Intestine Small, Ileum                             (45)         (47)         (42)         (43)         (45)         (46)         
   Intestine Small, Jejunum                           (48)         (49)         (44)         (46)         (47)         (50)         
      Leiomyoma                                                                                            1 (2%)                   
   Liver                                              (50)         (50)         (50)         (50)         (50)         (50)         
      Hepatocellular Adenoma                                                                                            3 (6%)      
      Hepatocellular Adenoma, Multiple                              1 (2%)                                                          
   Mesentery                                          (3)          (5)          (6)          (2)          (2)          (3)          
      Sarcoma                                                                                                           1 (33%)     
   Pancreas                                           (48)         (50)         (50)         (50)         (49)         (50)         
      Sarcoma, Metastatic, Mesentery                                                                                    1 (2%)      
   Pharynx                                                                                                (1)                       
      Palate, Squamous Cell Papilloma                                                                      1 (100%)                 
   Salivary Glands                                    (50)         (49)         (50)         (50)         (50)         (50)         
      Adenoma                                                       1 (2%)                                                          
   Stomach, Forestomach                               (49)         (50)         (47)         (50)         (48)         (49)         
   Stomach, Glandular                                 (49)         (50)         (47)         (49)         (49)         (49)         
   Tongue                                                          (2)                                    (1)                       
      Squamous Cell Papilloma                                       1 (50%)                                1 (100%)                 
   Tooth                                              (50)         (50)         (49)         (50)         (50)         (50)         
      Gingiva, Squamous Cell Carcinoma                                           1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page  12                                                               
NTP Experiment-Test: 05076-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 09/09/94  
Route: DOSED FEED                                                                                                 Time: 20:35:00  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 PPM        0 PPM        25 PPM       83 PPM       83 PPM       83 PPM          
                                                   0-0          10-0          1-1          0-3          3-3          10-3           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)         (50)         (50)         (50)         (50)         
      Schwannoma Malignant                                                                    1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (50)         (49)         (50)         (49)         (50)         
      Adenoma                                                       1 (2%)                                 1 (2%)       1 (2%)      
   Adrenal Gland, Medulla                             (50)         (50)         (49)         (49)         (49)         (50)         
      Pheochromocytoma Malignant                       2 (4%)       1 (2%)       1 (2%)       1 (2%)       4 (8%)       1 (2%)      
      Pheochromocytoma Benign                         16 (32%)     16 (32%)     18 (37%)     15 (31%)     13 (27%)     19 (38%)     
      Bilateral, Pheochromocytoma Benign               6 (12%)     15 (30%)      6 (12%)      7 (14%)     11 (22%)      5 (10%)     
   Islets, Pancreatic                                 (48)         (50)         (50)         (50)         (49)         (50)         
      Adenoma                                          2 (4%)       2 (4%)                    1 (2%)       1 (2%)       2 (4%)      
      Carcinoma                                        1 (2%)       1 (2%)       2 (4%)       1 (2%)                                
   Parathyroid Gland                                  (44)         (46)         (48)         (45)         (45)         (47)         
      Adenoma                                          1 (2%)       1 (2%)       2 (4%)                    1 (2%)       1 (2%)      
   Pituitary Gland                                    (50)         (50)         (48)         (47)         (49)         (49)         
      Pars Distalis, Adenoma                          19 (38%)     15 (30%)     10 (21%)     10 (21%)     13 (27%)     11 (22%)     
      Pars Distalis, Adenoma, Multiple                                                                                  1 (2%)      
      Pars Distalis, Carcinoma                                      1 (2%)                    1 (2%)                                
      Pars Intermedia, Adenoma                         1 (2%)                                                                       
   Thyroid Gland                                      (49)         (49)         (46)         (46)         (47)         (50)         
      Bilateral, C-Cell, Adenoma                       2 (4%)       1 (2%)       1 (2%)                                 1 (2%)      
      Bilateral, Follicular Cell, Adenoma                                                     1 (2%)       1 (2%)       1 (2%)      
      C-Cell, Adenoma                                  8 (16%)     10 (20%)      9 (20%)     12 (26%)     16 (34%)     12 (24%)     
      C-Cell, Carcinoma                                2 (4%)       1 (2%)       1 (2%)                                             
      Follicular Cell, Adenocarcinoma                  1 (2%)       3 (6%)       2 (4%)       3 (7%)       4 (9%)       6 (12%)     
      Follicular Cell, Adenoma                                      1 (2%)       1 (2%)       8 (17%)      9 (19%)      7 (14%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                                                                             (1)                       
      Carcinoma                                                                                            1 (100%)                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (50)         (50)         (50)         (50)         (49)         (50)         
      Sarcoma, Metastatic, Mesentery                                                                                    1 (2%)      
   Preputial Gland                                    (49)         (49)         (49)         (49)         (46)         (50)         
      Adenoma                                          2 (4%)       4 (8%)       1 (2%)                                 1 (2%)      
      Carcinoma                                        1 (2%)       1 (2%)       1 (2%)       1 (2%)                                
      Bilateral, Adenoma                                            1 (2%)                                                          
   Prostate                                           (50)         (50)         (50)         (50)         (50)         (49)         
                                                             Page  13                                                               
NTP Experiment-Test: 05076-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 09/09/94  
Route: DOSED FEED                                                                                                 Time: 20:35:00  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 PPM        0 PPM        25 PPM       83 PPM       83 PPM       83 PPM          
                                                   0-0          10-0          1-1          0-3          3-3          10-3           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - cont                                                                                                               
   Seminal Vesicle                                    (1)          (1)          (4)          (1)                                    
   Testes                                             (50)         (50)         (50)         (50)         (50)         (50)         
      Sarcoma, Metastatic, Mesentery                                                                                    1 (2%)      
      Bilateral, Interstitial Cell, Adenoma           35 (70%)     34 (68%)     39 (78%)     36 (72%)     40 (80%)     40 (80%)     
      Interstitial Cell, Adenoma                       7 (14%)     11 (22%)      5 (10%)      4 (8%)       5 (10%)      8 (16%)     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Blood                                              (17)         (25)         (24)         (21)         (24)         (26)         
   Bone Marrow                                        (50)         (50)         (50)         (50)         (49)         (50)         
   Lymph Node                                         (50)         (50)         (50)         (50)         (48)         (50)         
      Deep Cervical, Carcinoma, Metastatic,                                                                                         
          Thyroid Gland                                             1 (2%)                                                          
      Deep Cervical, Mediastinal, Mandibular,                                                                                       
          Fibrous Histiocytoma, Metastatic, Skin       1 (2%)                                                                       
      Lumbar, Fibrosarcoma, Metastatic, Skin                        1 (2%)                                                          
      Mandibular, Carcinoma, Metastatic, Zymbal's                                                                                   
          Gland                                        1 (2%)                                                                       
      Mediastinal, Pheochromocytoma Malignant,                                                                                      
           Metastatic, Adrenal Gland                                                                       1 (2%)                   
      Mediastinal, Sarcoma, Metastatic, Mesentery                                                                       1 (2%)      
   Lymph Node, Mesenteric                             (2)          (10)         (14)         (10)         (9)          (10)         
      Hemangiosarcoma                                               1 (10%)                                                         
   Spleen                                             (50)         (50)         (50)         (50)         (50)         (50)         
      Fibrosarcoma                                                  1 (2%)                                 1 (2%)                   
      Hemangiosarcoma                                  1 (2%)                                                                       
   Thymus                                             (40)         (39)         (45)         (42)         (40)         (38)         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (42)         (40)         (42)         (37)         (45)         (41)         
      Adenocarcinoma                                                                                       1 (2%)                   
      Adenoma                                                                                 1 (3%)                                
      Fibroadenoma                                                  1 (3%)       4 (10%)      2 (5%)       1 (2%)       1 (2%)      
   Skin                                               (50)         (49)         (50)         (50)         (49)         (50)         
      Basal Cell Adenoma, Multiple                                                            1 (2%)                                
      Basosquamous Tumor Benign                        1 (2%)                    2 (4%)                                             
      Basosquamous Tumor Benign, Multiple                                                                  1 (2%)                   
      Keratoacanthoma                                  1 (2%)       2 (4%)                    1 (2%)       1 (2%)                   
      Lipoma                                           1 (2%)                                                                       
      Squamous Cell Carcinoma                                                                              1 (2%)                   
      Squamous Cell Papilloma                                       1 (2%)                                 1 (2%)                   
      Trichoepithelioma                                                                                    1 (2%)                   
      Subcutaneous Tissue, Fibroma                                  2 (4%)       3 (6%)       1 (2%)       8 (16%)      1 (2%)      
      Subcutaneous Tissue, Fibrosarcoma                1 (2%)       1 (2%)       2 (4%)       2 (4%)       1 (2%)       3 (6%)      
                                                             Page  14                                                               
NTP Experiment-Test: 05076-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 09/09/94  
Route: DOSED FEED                                                                                                 Time: 20:35:00  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 PPM        0 PPM        25 PPM       83 PPM       83 PPM       83 PPM          
                                                   0-0          10-0          1-1          0-3          3-3          10-3           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - cont                                                                                                         
      Subcutaneous Tissue, Fibrous Histiocytoma        1 (2%)                                                                       
      Subcutaneous Tissue, Leiomyosarcoma                                                     1 (2%)                                
      Subcutaneous Tissue, Neurofibrosarcoma                                     1 (2%)                    1 (2%)                   
      Subcutaneous Tissue, Osteosarcoma,                                                                                            
          Metastatic, Bone                                          1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)         (50)         (50)         
      Squamous Cell Carcinoma, Metastatic, Skin                                                            1 (2%)                   
      Cervical, Osteoma                                                                       1 (2%)                                
      Femur, Osteosarcoma                                           1 (2%)                                              1 (2%)      
   Skeletal Muscle                                    (1)                                                 (1)          (1)          
      Diaphragm, Sarcoma, Metastatic, Mesentery                                                                         1 (100%)    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)         (50)         (50)         (50)         (50)         
      Carcinoma, Metastatic, Pituitary Gland                        1 (2%)                    1 (2%)                                
      Meningioma Benign                                                                                    1 (2%)                   
      Oligodendroglioma Malignant                                                1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)         (50)         (50)         
      Alveolar/Bronchiolar Adenoma                                               2 (4%)                    1 (2%)       1 (2%)      
      Alveolar/Bronchiolar Carcinoma                   1 (2%)                                              1 (2%)       1 (2%)      
      Carcinoma, Metastatic, Thyroid Gland             1 (2%)                                                                       
      Carcinoma, Metastatic, Zymbal's Gland            1 (2%)                                                                       
      Fibrosarcoma, Metastatic, Skin                                1 (2%)                                                          
      Pheochromocytoma Malignant, Metastatic,                                                                                       
          Adrenal Gland                                                                                    1 (2%)                   
      Schwannoma Malignant, Metastatic, Heart                                                 1 (2%)                                
   Nose                                               (50)         (50)         (50)         (50)         (49)         (50)         
      Squamous Cell Carcinoma, Metastatic, Skin                                                            1 (2%)                   
   Trachea                                            (50)         (50)         (50)         (50)         (50)         (50)         
      Adenocarcinoma, Metastatic, Thyroid Gland                                  1 (2%)                                 1 (2%)      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page  15                                                               
NTP Experiment-Test: 05076-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 09/09/94  
Route: DOSED FEED                                                                                                 Time: 20:35:00  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 PPM        0 PPM        25 PPM       83 PPM       83 PPM       83 PPM          
                                                   0-0          10-0          1-1          0-3          3-3          10-3           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                (1)                                    (2)          (1)                       
      Squamous Cell Papilloma                                                                 1 (50%)                               
   Harderian Gland                                    (48)         (50)         (49)         (49)         (50)         (50)         
   Zymbal's Gland                                     (1)          (1)          (1)          (3)          (2)          (2)          
      Carcinoma                                        1 (100%)     1 (100%)     1 (100%)     3 (100%)     1 (50%)      2 (100%)    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (49)         (50)         (50)         (50)         
      Cystadenocarcinoma                                                                                                1 (2%)      
      Myxoma                                                                     1 (2%)                                             
      Nephroblastoma                                                                          1 (2%)                                
      Capsule, Sarcoma, Metastatic, Mesentery                                                                           1 (2%)      
      Renal Tubule, Adenoma                                         1 (2%)       1 (2%)       4 (8%)       1 (2%)       1 (2%)      
      Renal Tubule, Adenoma, Multiple                                                                                   1 (2%)      
      Renal Tubule, Carcinoma, Multiple                                          1 (2%)                                             
   Urinary Bladder                                    (49)         (50)         (48)         (49)         (48)         (50)         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)        *(50)        *(50)        *(50)         
      Leukemia Monocytic                                                                                                1 (2%)      
      Leukemia Mononuclear                            22 (44%)     32 (64%)     29 (58%)     25 (50%)     31 (62%)     34 (68%)     
      Mesothelioma Malignant                                        2 (4%)       2 (4%)       1 (2%)       2 (4%)       1 (2%)      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  16                                                               
NTP Experiment-Test: 05076-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 09/09/94  
Route: DOSED FEED                                                                                                 Time: 20:35:00  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 PPM        0 PPM        25 PPM       83 PPM       83 PPM       83 PPM          
                                                   0-0          10-0          1-1          0-3          3-3          10-3           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            48          50          49          49          49          50               
     Total Primary Neoplasms                          136         173         151         147         179         170               
                                                                                                                                    
   Total Animals with Benign Neoplasms                 48          50          46          48          49          49               
     Total Benign Neoplasms                           102         126         106         106         130         118               
                                                                                                                                    
   Total Animals with Malignant Neoplasms              26          40          36          37          39          40               
     Total Malignant Neoplasms                         34          47          45          41          49          52               
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              3           4           1           2           2           2               
     Total Metastatic Neoplasm                          4           5           1           2           4           7               
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  17                                                               
NTP Experiment-Test: 05076-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 09/09/94  
Route: DOSED FEED                                                                                                 Time: 20:35:00  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     250 PPM      250 PPM                                                             
                                                     0-10        10-10                                                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           50                                                               
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                23           30                                                               
    Natural Death                                      8           14                                                               
    Accidently Killed                                  5                                                                            
  Survivors                                                                                                                         
    Moribund Sacrifice                                              1                                                               
    Natural Death                                                   1                                                               
    Terminal Sacrifice                                14            4                                                               
  Animals Examined Microscopically                    50           50                                                               
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (50)         (50)                                                             
      Adenocarcinoma, Metastatic, Thyroid Gland                     1 (2%)                                                          
   Intestine Small, Jejunum                           (42)         (45)                                                             
      Adenocarcinoma                                   1 (2%)                                                                       
   Liver                                              (50)         (50)                                                             
      Hepatocellular Carcinoma                                      1 (2%)                                                          
      Hepatocellular Adenoma                           1 (2%)       1 (2%)                                                          
      Osteosarcoma, Metastatic, Uncertain Primary                                                                                   
          Site                                                      1 (2%)                                                          
   Mesentery                                          (2)          (3)                                                              
   Pancreas                                           (49)         (50)                                                             
   Salivary Glands                                    (50)         (49)                                                             
      Adenocarcinoma, Metastatic, Thyroid Gland                     1 (2%)                                                          
   Stomach, Forestomach                               (49)         (50)                                                             
   Stomach, Glandular                                 (49)         (49)                                                             
   Tongue                                             (1)                                                                           
      Squamous Cell Papilloma                          1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (50)                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (50)                                                             
      Osteosarcoma, Metastatic, Uncertain Primary                                                                                   
          Site                                                      1 (2%)                                                          
      Bilateral, Adenoma                               1 (2%)                                                                       
                                                             Page  18                                                               
NTP Experiment-Test: 05076-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 09/09/94  
Route: DOSED FEED                                                                                                 Time: 20:35:00  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     250 PPM      250 PPM                                                             
                                                     0-10        10-10                                                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - cont                                                                                                             
   Adrenal Gland, Medulla                             (50)         (50)                                                             
      Pheochromocytoma Malignant                       1 (2%)       2 (4%)                                                          
      Pheochromocytoma Benign                         11 (22%)     15 (30%)                                                         
      Bilateral, Pheochromocytoma Benign              13 (26%)      7 (14%)                                                         
   Islets, Pancreatic                                 (50)         (50)                                                             
      Adenoma                                                       2 (4%)                                                          
      Carcinoma                                        1 (2%)       1 (2%)                                                          
   Parathyroid Gland                                  (33)         (21)                                                             
      Adenoma                                          1 (3%)                                                                       
   Pituitary Gland                                    (50)         (49)                                                             
      Pars Distalis, Adenoma                          11 (22%)     11 (22%)                                                         
   Thyroid Gland                                      (50)         (50)                                                             
      Bilateral, Follicular Cell, Adenocarcinoma      11 (22%)     23 (46%)                                                         
      Bilateral, Follicular Cell, Adenocarcinoma,                                                                                   
           Multiple                                    1 (2%)       1 (2%)                                                          
      Bilateral, Follicular Cell, Adenoma              6 (12%)      2 (4%)                                                          
      Bilateral, Follicular Cell, Adenoma, Multiple    2 (4%)       4 (8%)                                                          
      C-Cell, Adenoma                                  9 (18%)      3 (6%)                                                          
      Follicular Cell, Adenocarcinoma                 14 (28%)     20 (40%)                                                         
      Follicular Cell, Adenoma                        11 (22%)     20 (40%)                                                         
      Follicular Cell, Adenoma, Multiple               4 (8%)       8 (16%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (49)         (50)                                                             
   Preputial Gland                                    (49)         (50)                                                             
      Adenoma                                                       3 (6%)                                                          
      Carcinoma                                        1 (2%)                                                                       
      Squamous Cell Carcinoma                          1 (2%)                                                                       
   Prostate                                           (49)         (50)                                                             
   Seminal Vesicle                                                 (2)                                                              
   Testes                                             (50)         (50)                                                             
      Bilateral, Interstitial Cell, Adenoma           30 (60%)     33 (66%)                                                         
      Interstitial Cell, Adenoma                      10 (20%)     12 (24%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page  19                                                               
NTP Experiment-Test: 05076-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 09/09/94  
Route: DOSED FEED                                                                                                 Time: 20:35:00  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     250 PPM      250 PPM                                                             
                                                     0-10        10-10                                                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Blood                                              (14)         (22)                                                             
   Bone Marrow                                        (49)         (50)                                                             
      Femoral, Osteosarcoma, Metastatic, Uncertain                                                                                  
          Primary Site                                              1 (2%)                                                          
   Lymph Node                                         (50)         (49)                                                             
      Mediastinal, Adenocarcinoma, Metastatic,                                                                                      
           Thyroid Gland                                            1 (2%)                                                          
   Lymph Node, Mesenteric                             (14)         (10)                                                             
   Spleen                                             (50)         (50)                                                             
   Thymus                                             (43)         (44)                                                             
      Thymoma Benign                                                2 (5%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (49)         (49)                                                             
      Keratoacanthoma                                  1 (2%)       1 (2%)                                                          
      Subcutaneous Tissue, Adenocarcinoma,                                                                                          
          Metastatic, Thyroid Gland                    1 (2%)                                                                       
      Subcutaneous Tissue, Fibroma                                  1 (2%)                                                          
      Subcutaneous Tissue, Fibrosarcoma                             1 (2%)                                                          
      Subcutaneous Tissue, Hemangiosarcoma             1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                    (5)          (2)                                                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (50)                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)                                                             
      Adenocarcinoma, Metastatic, Thyroid Gland        1 (2%)       1 (2%)                                                          
      Osteosarcoma, Metastatic, Uncertain Primary                                                                                   
          Site                                         1 (2%)       1 (2%)                                                          
      Pheochromocytoma Malignant, Metastatic,                                                                                       
          Adrenal Gland                                             1 (2%)                                                          
   Nose                                               (50)         (50)                                                             
      Nasolacrimal Duct, Squamous Cell Carcinoma       1 (2%)                                                                       
   Trachea                                            (50)         (50)                                                             
      Adenocarcinoma, Metastatic, Thyroid Gland                     2 (4%)                                                          
                                                             Page  20                                                               
NTP Experiment-Test: 05076-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 09/09/94  
Route: DOSED FEED                                                                                                 Time: 20:35:00  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     250 PPM      250 PPM                                                             
                                                     0-10        10-10                                                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (49)         (50)                                                             
   Zymbal's Gland                                     (3)          (5)                                                              
      Adenoma                                          1 (33%)                                                                      
      Carcinoma                                        2 (67%)      4 (80%)                                                         
      Bilateral, Carcinoma                                          1 (20%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)                                                             
      Renal Tubule, Adenoma                            3 (6%)                                                                       
      Renal Tubule, Carcinoma                          1 (2%)                                                                       
      Transitional Epithelium, Carcinoma                            1 (2%)                                                          
   Urinary Bladder                                    (49)         (50)                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)                                                             
      Leukemia Mononuclear                            26 (52%)     29 (58%)                                                         
      Lymphoma Malignant Histiocytic                   1 (2%)                                                                       
      Mesothelioma Malignant                                        3 (6%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  21                                                               
NTP Experiment-Test: 05076-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          ETHYLENETHIOUREA                                     Date: 09/09/94  
Route: DOSED FEED                                                                                                 Time: 20:35:00  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     250 PPM      250 PPM                                                             
                                                     0-10        10-10                                                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            45          50                                                               
     Total Primary Neoplasms                          179         212                                                               
                                                                                                                                    
   Total Animals with Benign Neoplasms                 45          49                                                               
     Total Benign Neoplasms                           116         125                                                               
                                                                                                                                    
   Total Animals with Malignant Neoplasms              41          50                                                               
     Total Malignant Neoplasms                         63          87                                                               
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              3           6                                                               
     Total Metastatic Neoplasm                          3          11                                                               
                                                                                                                                    
   Total Animals with Malignant Neoplasms               1           1                                                               
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  22                                                               
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                             ----------              END OF REPORT             ----------                                           
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NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.