TR 389 Rat Pathology Tables
INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
SODIUM AZIDE
NTP Experiment-Test: 05026-01 Report: PEIRPT05
Study Type: CHRONIC Date: 09/04/94
Route: GAVAGE Time: 07:44:14
Facility: Microbiological Associates
Chemical CAS #: 26628228
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05026-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC SODIUM AZIDE Date: 09/04/94
Route: GAVAGE Time: 07:44:14
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 G/KG 5 MG/KG 10MG/KG
VEHICLEF LOW FEMA HIGH FEM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 60 60 60
Early Deaths
Dead 13 5 22
Moribund 10 12 11
Gavage Death 5
Survivors
Dead 1
Terminal Sacrifice 36 43 21
Wrong Sex 1
Animals Examined Microscopically 60 60 59
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Cecum (54) (58) (55)
Hemangioma 1 (2%)
Intestine Large, Colon (56) (59) (57)
Polyp Adenomatous 1 (2%)
Intestine Small, Duodenum (55) (58) (52)
Intestine Small, Ileum (53) (58) (51)
Intestine Small, Jejunum (50) (57) (49)
Carcinoma 1 (2%)
Liver (60) (60) (59)
Neoplastic Nodule 1 (2%)
Sarcoma, Metastatic, Spleen 1 (2%)
Mesentery (16) (10) (7)
Sarcoma, Metastatic, Kidney 1 (6%)
Sarcoma, Metastatic, Spleen 1 (10%)
Pancreas (60) (60) (58)
Sarcoma, Metastatic, Spleen 1 (2%)
Stomach (60) (60) (58)
Duodenum, Carcinoma, Metastatic, Intestine
Small 1 (2%)
Stomach, Forestomach (60) (57) (57)
Squamous Cell Papilloma 1 (2%)
Stomach, Glandular (60) (60) (57)
Tongue (1) (1)
Squamous Cell Carcinoma 1 (100%)
Squamous Cell Papilloma 1 (100%)
____________________________________________________________________________________________________________________________________
Page 2
NTP Experiment-Test: 05026-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC SODIUM AZIDE Date: 09/04/94
Route: GAVAGE Time: 07:44:14
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 G/KG 5 MG/KG 10MG/KG
VEHICLEF LOW FEMA HIGH FEM
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (60) (60) (58)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland (60) (60) (59)
Extra Adrenal Tissue, Sarcoma, Metastatic,
Spleen 1 (2%)
Adrenal Gland, Cortex (60) (60) (58)
Adenoma 1 (2%) 2 (3%)
Adrenal Gland, Medulla (58) (54) (56)
Ganglioneuroma 1 (2%)
Pheochromocytoma Malignant 1 (2%)
Pheochromocytoma Benign 1 (2%) 3 (6%) 1 (2%)
Bilateral, Pheochromocytoma Benign 1 (2%)
Islets, Pancreatic (60) (60) (58)
Adenoma 1 (2%) 1 (2%)
Parathyroid Gland (48) (49) (48)
Pituitary Gland (60) (60) (59)
Pars Distalis, Adenoma 35 (58%) 27 (45%) 17 (29%)
Pars Distalis, Carcinoma 2 (3%) 1 (2%)
Pars Intermedia, Carcinoma 1 (2%)
Thyroid Gland (60) (60) (56)
Bilateral, C-Cell, Adenoma 1 (2%)
C-Cell, Adenoma 3 (5%) 2 (3%) 3 (5%)
C-Cell, Carcinoma 3 (5%) 1 (2%)
Follicular Cell, Adenoma 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (55) (57) (49)
Adenoma 4 (7%) 2 (4%) 5 (10%)
Carcinoma 1 (2%) 2 (4%)
Ovary (60) (60) (59)
Carcinoma, Metastatic, Intestine Small 1 (2%)
Uterus (60) (60) (59)
Adenocarcinoma 1 (2%)
Carcinoma, Metastatic, Intestine Small 1 (2%)
Polyp Stromal 9 (15%) 18 (30%) 8 (14%)
Polyp Stromal, Multiple 3 (5%) 2 (3%) 3 (5%)
Page 3
NTP Experiment-Test: 05026-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC SODIUM AZIDE Date: 09/04/94
Route: GAVAGE Time: 07:44:14
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 G/KG 5 MG/KG 10MG/KG
VEHICLEF LOW FEMA HIGH FEM
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont
Sarcoma, Metastatic, Spleen 1 (2%)
Sarcoma Stromal 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (60) (60) (59)
Histiocytic Sarcoma 1 (2%)
Lymph Node (59) (59) (59)
Deep Cervical, Carcinoma, Metastatic 1 (2%)
Mediastinal, Sarcoma, Metastatic, Spleen 1 (2%)
Mesenteric, Carcinoma, Metastatic, Intestine
Small 1 (2%)
Lymph Node, Mandibular (51) (52) (50)
Spleen (60) (60) (59)
Sarcoma, Metastatic 1 (2%)
Thymus (42) (51) (49)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (58) (55) (56)
Adenocarcinoma 1 (2%) 1 (2%) 2 (4%)
Adenoma 2 (3%)
Carcinoma 1 (2%) 1 (2%)
Fibroadenoma 15 (26%) 9 (16%) 8 (14%)
Fibroadenoma, Multiple 5 (9%) 2 (4%)
Skin (59) (60) (59)
Subcutaneous Tissue, Fibroma 4 (7%) 1 (2%) 1 (2%)
Subcutaneous Tissue, Sarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (2)
Vertebra, Chondroma 1 (50%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (60) (60) (58)
Astrocytoma Benign 1 (2%)
Carcinoma, Metastatic, Pituitary Gland 2 (3%) 1 (2%)
Oligodendroglioma Benign 1 (2%)
____________________________________________________________________________________________________________________________________
Page 4
NTP Experiment-Test: 05026-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC SODIUM AZIDE Date: 09/04/94
Route: GAVAGE Time: 07:44:14
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 G/KG 5 MG/KG 10MG/KG
VEHICLEF LOW FEMA HIGH FEM
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (60) (60) (59)
Alveolar/Bronchiolar Carcinoma 1 (2%)
Carcinoma, Metastatic, Mammary Gland 1 (2%)
Carcinoma, Metastatic, Intestine Small 1 (2%)
Sarcoma, Metastatic, Spleen 1 (2%)
Nose (60) (60) (59)
Squamous Cell Carcinoma 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (4) (7) (3)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (60) (60) (59)
Sarcoma 1 (2%)
Sarcoma, Metastatic, Spleen 1 (2%)
Renal Tubule, Carcinoma 1 (2%)
Urinary Bladder (60) (58) (58)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(60) *(60) *(59)
Histiocytic Sarcoma 1 (2%)
Leukemia Mononuclear 16 (27%) 18 (30%) 11 (19%)
Lymphoma Malignant Lymphocytic 1 (2%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 5
NTP Experiment-Test: 05026-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC SODIUM AZIDE Date: 09/04/94
Route: GAVAGE Time: 07:44:14
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 G/KG 5 MG/KG 10MG/KG
VEHICLEF LOW FEMA HIGH FEM
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 53 54 39
Total Primary Neoplasms 115 104 66
Total Animals with Benign Neoplasms 47 44 34
Total Benign Neoplasms 87 75 49
Total Animals with Malignant Neoplasms 25 26 16
Total Malignant Neoplasms 28 29 17
Total Animals with Metastatic Neoplasms 5 3
Total Metastatic Neoplasm 5 15
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
Page 6
NTP Experiment-Test: 05026-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC SODIUM AZIDE Date: 09/04/94
Route: GAVAGE Time: 07:44:14
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 G/KG 5 MG/KG 10 MG/KG
VEHICLEM LOW MALE HIGHMALE
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially in Study 60 60 60
Early Deaths
Dead 16 14 26
Moribund 19 17 16
Gavage Death 1 2 9
Survivors
Terminal Sacrifice 24 27 9
Animals Examined Microscopically 60 60 60
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (50) (54) (55)
Intestine Small, Duodenum (46) (54) (46)
Adenocarcinoma 1 (2%)
Leiomyoma 1 (2%)
Intestine Small, Ileum (43) (52) (48)
Intestine Small, Jejunum (42) (51) (44)
Liver (60) (60) (60)
Hepatocellular Adenoma 2 (3%)
Neoplastic Nodule 3 (5%) 1 (2%)
Mesentery (9) (13) (8)
Pancreas (57) (60) (60)
Hemangiosarcoma, Metastatic, Spleen 1 (2%)
Acinus, Adenoma 1 (2%)
Salivary Glands (59) (60) (60)
Stomach, Forestomach (58) (59) (60)
Stomach, Glandular (58) (60) (59)
Leiomyosarcoma 1 (2%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (60) (60) (60)
Pericardium, Carcinoma, Metastatic, Lung 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (60) (60) (60)
Adrenal Gland, Medulla (55) (56) (53)
Pheochromocytoma Malignant 1 (2%) 1 (2%) 2 (4%)
Pheochromocytoma Benign 17 (31%) 13 (23%) 3 (6%)
Bilateral, Pheochromocytoma Benign 8 (15%) 2 (4%) 1 (2%)
Page 7
NTP Experiment-Test: 05026-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC SODIUM AZIDE Date: 09/04/94
Route: GAVAGE Time: 07:44:14
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 G/KG 5 MG/KG 10 MG/KG
VEHICLEM LOW MALE HIGHMALE
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont
Islets, Pancreatic (59) (60) (60)
Adenoma 3 (5%) 2 (3%) 1 (2%)
Carcinoma 2 (3%) 2 (3%)
Pituitary Gland (59) (60) (60)
Pars Distalis, Adenoma 23 (39%) 23 (38%) 15 (25%)
Thyroid Gland (57) (58) (59)
C-Cell, Adenoma 3 (5%) 7 (12%) 3 (5%)
C-Cell, Carcinoma 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (60) (60) (60)
Preputial Gland (59) (59) (55)
Adenoma 7 (12%) 9 (15%) 3 (5%)
Carcinoma 1 (2%)
Prostate (60) (60) (60)
Seminal Vesicle (59) (60) (60)
Testes (60) (60) (60)
Bilateral, Interstitial Cell, Adenoma 43 (72%) 35 (58%) 35 (58%)
Interstitial Cell, Adenoma 9 (15%) 16 (27%) 9 (15%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (59) (60) (60)
Lymph Node (58) (56) (58)
Mediastinal, Carcinoma, Metastatic, Lung 1 (2%)
Lymph Node, Mandibular (55) (55) (55)
Spleen (60) (60) (60)
Fibrosarcoma 1 (2%)
Hemangiosarcoma 1 (2%) 1 (2%)
Thymus (49) (45) (49)
Carcinoma, Metastatic, Lung 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (47) (52) (50)
Adenoma 1 (2%)
Fibroadenoma 2 (4%)
Skin (58) (59) (60)
Page 8
NTP Experiment-Test: 05026-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC SODIUM AZIDE Date: 09/04/94
Route: GAVAGE Time: 07:44:14
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 G/KG 5 MG/KG 10 MG/KG
VEHICLEM LOW MALE HIGHMALE
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont
Keratoacanthoma 1 (2%) 1 (2%) 1 (2%)
Squamous Cell Carcinoma 2 (3%)
Squamous Cell Papilloma 1 (2%) 2 (3%)
Trichoepithelioma 2 (3%) 1 (2%)
Subcutaneous Tissue, Fibroma 2 (3%) 4 (7%) 2 (3%)
Subcutaneous Tissue, Fibroma, Multiple 1 (2%)
Subcutaneous Tissue, Fibrosarcoma 1 (2%)
Subcutaneous Tissue, Schwannoma Malignant 2 (3%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (1) (2)
Femur, Osteosarcoma 1 (50%)
Sternum, Carcinoma, Metastatic, Lung 1 (100%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (60) (60) (60)
Cerebrum, Glioma Benign 1 (2%)
Cerebrum, Granular Cell Tumor Benign 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (60) (60) (60)
Alveolar/Bronchiolar Adenoma 1 (2%)
Alveolar/Bronchiolar Carcinoma 1 (2%) 1 (2%)
Carcinoma, Metastatic, Zymbal's Gland 1 (2%)
Fibrosarcoma, Metastatic, Spleen 1 (2%)
Osteosarcoma, Metastatic, Nose 1 (2%)
Nose (59) (60) (60)
Osteosarcoma 1 (2%)
Squamous Cell Carcinoma 1 (2%)
Trachea (58) (60) (60)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (10) (4) (4)
Zymbal's Gland (3) (1)
Adenoma 1 (100%)
Carcinoma 3 (100%)
____________________________________________________________________________________________________________________________________
Page 9
NTP Experiment-Test: 05026-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC SODIUM AZIDE Date: 09/04/94
Route: GAVAGE Time: 07:44:14
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 G/KG 5 MG/KG 10 MG/KG
VEHICLEM LOW MALE HIGHMALE
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (60) (60) (60)
Renal Tubule, Adenoma 2 (3%) 1 (2%) 1 (2%)
Urinary Bladder (60) (60) (59)
____________________________________________________________________________________________________________________________________
SYSTEMIC LESIONS
Multiple Organs *(60) *(60) *(60)
Leukemia Mononuclear 33 (55%) 28 (47%) 14 (23%)
Mesothelioma Malignant 1 (2%) 2 (3%) 2 (3%)
____________________________________________________________________________________________________________________________________
* Number of animals with any tissue examined microscopically
Page 10
NTP Experiment-Test: 05026-01 INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a) Report: PEIRPT05
Study Type: CHRONIC SODIUM AZIDE Date: 09/04/94
Route: GAVAGE Time: 07:44:14
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 G/KG 5 MG/KG 10 MG/KG
VEHICLEM LOW MALE HIGHMALE
____________________________________________________________________________________________________________________________________
TUMOR SUMMARY
Total Animals with Primary Neoplasms (b) 59 58 50
Total Primary Neoplasms 173 159 103
Total Animals with Benign Neoplasms 58 57 49
Total Benign Neoplasms 129 119 79
Total Animals with Malignant Neoplasms 40 33 23
Total Malignant Neoplasms 44 40 24
Total Animals with Metastatic Neoplasms 4 2 3
Total Metastatic Neoplasm 10 4 4
Total Animals with Malignant Neoplasms
Uncertain Primary Site
Total Animals with Neoplasms Uncertain-
Benign or Malignant
Total Uncertain Neoplasms
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
b Primary tumors: all tumors except metastatic tumors
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