National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/3768

TR 389 Rat Pathology Tables


                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                            SODIUM AZIDE


NTP Experiment-Test: 05026-01                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 09/04/94
Route: GAVAGE                                                                                                     Time: 07:44:14




       Facility:  Microbiological Associates

       Chemical CAS #:  26628228

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05026-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            SODIUM AZIDE                                       Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 07:44:14  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 G/KG       5 MG/KG      10MG/KG                                                
                                                   VEHICLEF     LOW FEMA     HIGH FEM                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          60           60           60                                                  
  Early Deaths                                                                                                                      
    Dead                                              13            5           22                                                  
    Moribund                                          10           12           11                                                  
    Gavage Death                                                                 5                                                  
  Survivors                                                                                                                         
    Dead                                               1                                                                            
    Terminal Sacrifice                                36           43           21                                                  
  Wrong Sex                                                                      1                                                  
  Animals Examined Microscopically                    60           60           59                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (54)         (58)         (55)                                                
      Hemangioma                                       1 (2%)                                                                       
   Intestine Large, Colon                             (56)         (59)         (57)                                                
      Polyp Adenomatous                                                          1 (2%)                                             
   Intestine Small, Duodenum                          (55)         (58)         (52)                                                
   Intestine Small, Ileum                             (53)         (58)         (51)                                                
   Intestine Small, Jejunum                           (50)         (57)         (49)                                                
      Carcinoma                                                     1 (2%)                                                          
   Liver                                              (60)         (60)         (59)                                                
      Neoplastic Nodule                                1 (2%)                                                                       
      Sarcoma, Metastatic, Spleen                                   1 (2%)                                                          
   Mesentery                                          (16)         (10)         (7)                                                 
      Sarcoma, Metastatic, Kidney                      1 (6%)                                                                       
      Sarcoma, Metastatic, Spleen                                   1 (10%)                                                         
   Pancreas                                           (60)         (60)         (58)                                                
      Sarcoma, Metastatic, Spleen                                   1 (2%)                                                          
   Stomach                                            (60)         (60)         (58)                                                
      Duodenum, Carcinoma, Metastatic, Intestine                                                                                    
          Small                                                     1 (2%)                                                          
   Stomach, Forestomach                               (60)         (57)         (57)                                                
      Squamous Cell Papilloma                                                    1 (2%)                                             
   Stomach, Glandular                                 (60)         (60)         (57)                                                
   Tongue                                             (1)          (1)                                                              
      Squamous Cell Carcinoma                                       1 (100%)                                                        
      Squamous Cell Papilloma                          1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   2                                                               
NTP Experiment-Test: 05026-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            SODIUM AZIDE                                       Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 07:44:14  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 G/KG       5 MG/KG      10MG/KG                                                
                                                   VEHICLEF     LOW FEMA     HIGH FEM                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (60)         (60)         (58)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (60)         (60)         (59)                                                
      Extra Adrenal Tissue, Sarcoma, Metastatic,                                                                                    
           Spleen                                                   1 (2%)                                                          
   Adrenal Gland, Cortex                              (60)         (60)         (58)                                                
      Adenoma                                          1 (2%)       2 (3%)                                                          
   Adrenal Gland, Medulla                             (58)         (54)         (56)                                                
      Ganglioneuroma                                                1 (2%)                                                          
      Pheochromocytoma Malignant                                    1 (2%)                                                          
      Pheochromocytoma Benign                          1 (2%)       3 (6%)       1 (2%)                                             
      Bilateral, Pheochromocytoma Benign                            1 (2%)                                                          
   Islets, Pancreatic                                 (60)         (60)         (58)                                                
      Adenoma                                          1 (2%)       1 (2%)                                                          
   Parathyroid Gland                                  (48)         (49)         (48)                                                
   Pituitary Gland                                    (60)         (60)         (59)                                                
      Pars Distalis, Adenoma                          35 (58%)     27 (45%)     17 (29%)                                            
      Pars Distalis, Carcinoma                         2 (3%)       1 (2%)                                                          
      Pars Intermedia, Carcinoma                                    1 (2%)                                                          
   Thyroid Gland                                      (60)         (60)         (56)                                                
      Bilateral, C-Cell, Adenoma                                    1 (2%)                                                          
      C-Cell, Adenoma                                  3 (5%)       2 (3%)       3 (5%)                                             
      C-Cell, Carcinoma                                3 (5%)       1 (2%)                                                          
      Follicular Cell, Adenoma                         1 (2%)       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (55)         (57)         (49)                                                
      Adenoma                                          4 (7%)       2 (4%)       5 (10%)                                            
      Carcinoma                                        1 (2%)       2 (4%)                                                          
   Ovary                                              (60)         (60)         (59)                                                
      Carcinoma, Metastatic, Intestine Small                        1 (2%)                                                          
   Uterus                                             (60)         (60)         (59)                                                
      Adenocarcinoma                                                             1 (2%)                                             
      Carcinoma, Metastatic, Intestine Small                        1 (2%)                                                          
      Polyp Stromal                                    9 (15%)     18 (30%)      8 (14%)                                            
      Polyp Stromal, Multiple                          3 (5%)       2 (3%)       3 (5%)                                             
                                                             Page   3                                                               
NTP Experiment-Test: 05026-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            SODIUM AZIDE                                       Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 07:44:14  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 G/KG       5 MG/KG      10MG/KG                                                
                                                   VEHICLEF     LOW FEMA     HIGH FEM                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - cont                                                                                                               
      Sarcoma, Metastatic, Spleen                                   1 (2%)                                                          
      Sarcoma Stromal                                                            1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (60)         (60)         (59)                                                
      Histiocytic Sarcoma                              1 (2%)                                                                       
   Lymph Node                                         (59)         (59)         (59)                                                
      Deep Cervical, Carcinoma, Metastatic             1 (2%)                                                                       
      Mediastinal, Sarcoma, Metastatic, Spleen                      1 (2%)                                                          
      Mesenteric, Carcinoma, Metastatic, Intestine                                                                                  
          Small                                                     1 (2%)                                                          
   Lymph Node, Mandibular                             (51)         (52)         (50)                                                
   Spleen                                             (60)         (60)         (59)                                                
      Sarcoma, Metastatic                                           1 (2%)                                                          
   Thymus                                             (42)         (51)         (49)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (58)         (55)         (56)                                                
      Adenocarcinoma                                   1 (2%)       1 (2%)       2 (4%)                                             
      Adenoma                                          2 (3%)                                                                       
      Carcinoma                                        1 (2%)                    1 (2%)                                             
      Fibroadenoma                                    15 (26%)      9 (16%)      8 (14%)                                            
      Fibroadenoma, Multiple                           5 (9%)       2 (4%)                                                          
   Skin                                               (59)         (60)         (59)                                                
      Subcutaneous Tissue, Fibroma                     4 (7%)       1 (2%)       1 (2%)                                             
      Subcutaneous Tissue, Sarcoma                     1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                                            (2)                                                              
      Vertebra, Chondroma                                           1 (50%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (60)         (60)         (58)                                                
      Astrocytoma Benign                                                         1 (2%)                                             
      Carcinoma, Metastatic, Pituitary Gland           2 (3%)       1 (2%)                                                          
      Oligodendroglioma Benign                                      1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   4                                                               
NTP Experiment-Test: 05026-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            SODIUM AZIDE                                       Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 07:44:14  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 G/KG       5 MG/KG      10MG/KG                                                
                                                   VEHICLEF     LOW FEMA     HIGH FEM                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (60)         (59)                                                
      Alveolar/Bronchiolar Carcinoma                                1 (2%)                                                          
      Carcinoma, Metastatic, Mammary Gland             1 (2%)                                                                       
      Carcinoma, Metastatic, Intestine Small                        1 (2%)                                                          
      Sarcoma, Metastatic, Spleen                                   1 (2%)                                                          
   Nose                                               (60)         (60)         (59)                                                
      Squamous Cell Carcinoma                          1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (4)          (7)          (3)                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (60)         (59)                                                
      Sarcoma                                          1 (2%)                                                                       
      Sarcoma, Metastatic, Spleen                                   1 (2%)                                                          
      Renal Tubule, Carcinoma                                                    1 (2%)                                             
   Urinary Bladder                                    (60)         (58)         (58)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(60)        *(60)        *(59)                                                
      Histiocytic Sarcoma                              1 (2%)                                                                       
      Leukemia Mononuclear                            16 (27%)     18 (30%)     11 (19%)                                            
      Lymphoma Malignant Lymphocytic                                1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   5                                                               
NTP Experiment-Test: 05026-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            SODIUM AZIDE                                       Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 07:44:14  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   0 G/KG       5 MG/KG      10MG/KG                                                
                                                   VEHICLEF     LOW FEMA     HIGH FEM                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            53          54          39                                                   
     Total Primary Neoplasms                          115         104          66                                                   
                                                                                                                                    
   Total Animals with Benign Neoplasms                 47          44          34                                                   
     Total Benign Neoplasms                            87          75          49                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms              25          26          16                                                   
     Total Malignant Neoplasms                         28          29          17                                                   
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              5           3                                                               
     Total Metastatic Neoplasm                          5          15                                                               
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   6                                                               
NTP Experiment-Test: 05026-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            SODIUM AZIDE                                       Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 07:44:14  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 G/KG       5 MG/KG      10 MG/KG                                               
                                                   VEHICLEM     LOW MALE     HIGHMALE                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          60           60           60                                                  
  Early Deaths                                                                                                                      
    Dead                                              16           14           26                                                  
    Moribund                                          19           17           16                                                  
    Gavage Death                                       1            2            9                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                24           27            9                                                  
  Animals Examined Microscopically                    60           60           60                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (50)         (54)         (55)                                                
   Intestine Small, Duodenum                          (46)         (54)         (46)                                                
      Adenocarcinoma                                                1 (2%)                                                          
      Leiomyoma                                        1 (2%)                                                                       
   Intestine Small, Ileum                             (43)         (52)         (48)                                                
   Intestine Small, Jejunum                           (42)         (51)         (44)                                                
   Liver                                              (60)         (60)         (60)                                                
      Hepatocellular Adenoma                                        2 (3%)                                                          
      Neoplastic Nodule                                3 (5%)       1 (2%)                                                          
   Mesentery                                          (9)          (13)         (8)                                                 
   Pancreas                                           (57)         (60)         (60)                                                
      Hemangiosarcoma, Metastatic, Spleen              1 (2%)                                                                       
      Acinus, Adenoma                                                            1 (2%)                                             
   Salivary Glands                                    (59)         (60)         (60)                                                
   Stomach, Forestomach                               (58)         (59)         (60)                                                
   Stomach, Glandular                                 (58)         (60)         (59)                                                
      Leiomyosarcoma                                                1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (60)         (60)         (60)                                                
      Pericardium, Carcinoma, Metastatic, Lung         1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (60)         (60)         (60)                                                
   Adrenal Gland, Medulla                             (55)         (56)         (53)                                                
      Pheochromocytoma Malignant                       1 (2%)       1 (2%)       2 (4%)                                             
      Pheochromocytoma Benign                         17 (31%)     13 (23%)      3 (6%)                                             
      Bilateral, Pheochromocytoma Benign               8 (15%)      2 (4%)       1 (2%)                                             
                                                             Page   7                                                               
NTP Experiment-Test: 05026-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            SODIUM AZIDE                                       Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 07:44:14  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 G/KG       5 MG/KG      10 MG/KG                                               
                                                   VEHICLEM     LOW MALE     HIGHMALE                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - cont                                                                                                             
   Islets, Pancreatic                                 (59)         (60)         (60)                                                
      Adenoma                                          3 (5%)       2 (3%)       1 (2%)                                             
      Carcinoma                                        2 (3%)       2 (3%)                                                          
   Pituitary Gland                                    (59)         (60)         (60)                                                
      Pars Distalis, Adenoma                          23 (39%)     23 (38%)     15 (25%)                                            
   Thyroid Gland                                      (57)         (58)         (59)                                                
      C-Cell, Adenoma                                  3 (5%)       7 (12%)      3 (5%)                                             
      C-Cell, Carcinoma                                             1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (60)         (60)         (60)                                                
   Preputial Gland                                    (59)         (59)         (55)                                                
      Adenoma                                          7 (12%)      9 (15%)      3 (5%)                                             
      Carcinoma                                                     1 (2%)                                                          
   Prostate                                           (60)         (60)         (60)                                                
   Seminal Vesicle                                    (59)         (60)         (60)                                                
   Testes                                             (60)         (60)         (60)                                                
      Bilateral, Interstitial Cell, Adenoma           43 (72%)     35 (58%)     35 (58%)                                            
      Interstitial Cell, Adenoma                       9 (15%)     16 (27%)      9 (15%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (59)         (60)         (60)                                                
   Lymph Node                                         (58)         (56)         (58)                                                
      Mediastinal, Carcinoma, Metastatic, Lung         1 (2%)                                                                       
   Lymph Node, Mandibular                             (55)         (55)         (55)                                                
   Spleen                                             (60)         (60)         (60)                                                
      Fibrosarcoma                                                  1 (2%)                                                          
      Hemangiosarcoma                                  1 (2%)                    1 (2%)                                             
   Thymus                                             (49)         (45)         (49)                                                
      Carcinoma, Metastatic, Lung                      1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (47)         (52)         (50)                                                
      Adenoma                                          1 (2%)                                                                       
      Fibroadenoma                                     2 (4%)                                                                       
   Skin                                               (58)         (59)         (60)                                                
                                                             Page   8                                                               
NTP Experiment-Test: 05026-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            SODIUM AZIDE                                       Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 07:44:14  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 G/KG       5 MG/KG      10 MG/KG                                               
                                                   VEHICLEM     LOW MALE     HIGHMALE                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - cont                                                                                                         
      Keratoacanthoma                                  1 (2%)       1 (2%)       1 (2%)                                             
      Squamous Cell Carcinoma                          2 (3%)                                                                       
      Squamous Cell Papilloma                          1 (2%)                    2 (3%)                                             
      Trichoepithelioma                                2 (3%)       1 (2%)                                                          
      Subcutaneous Tissue, Fibroma                     2 (3%)       4 (7%)       2 (3%)                                             
      Subcutaneous Tissue, Fibroma, Multiple                        1 (2%)                                                          
      Subcutaneous Tissue, Fibrosarcoma                                          1 (2%)                                             
      Subcutaneous Tissue, Schwannoma Malignant                                  2 (3%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (1)                       (2)                                                 
      Femur, Osteosarcoma                                                        1 (50%)                                            
      Sternum, Carcinoma, Metastatic, Lung             1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (60)         (60)         (60)                                                
      Cerebrum, Glioma Benign                                                    1 (2%)                                             
      Cerebrum, Granular Cell Tumor Benign                                       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (60)         (60)                                                
      Alveolar/Bronchiolar Adenoma                     1 (2%)                                                                       
      Alveolar/Bronchiolar Carcinoma                   1 (2%)       1 (2%)                                                          
      Carcinoma, Metastatic, Zymbal's Gland            1 (2%)                                                                       
      Fibrosarcoma, Metastatic, Spleen                              1 (2%)                                                          
      Osteosarcoma, Metastatic, Nose                                             1 (2%)                                             
   Nose                                               (59)         (60)         (60)                                                
      Osteosarcoma                                                               1 (2%)                                             
      Squamous Cell Carcinoma                                       1 (2%)                                                          
   Trachea                                            (58)         (60)         (60)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (10)         (4)          (4)                                                 
   Zymbal's Gland                                     (3)          (1)                                                              
      Adenoma                                                       1 (100%)                                                        
      Carcinoma                                        3 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   9                                                               
NTP Experiment-Test: 05026-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            SODIUM AZIDE                                       Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 07:44:14  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 G/KG       5 MG/KG      10 MG/KG                                               
                                                   VEHICLEM     LOW MALE     HIGHMALE                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (60)         (60)                                                
      Renal Tubule, Adenoma                            2 (3%)       1 (2%)       1 (2%)                                             
   Urinary Bladder                                    (60)         (60)         (59)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(60)        *(60)        *(60)                                                
      Leukemia Mononuclear                            33 (55%)     28 (47%)     14 (23%)                                            
      Mesothelioma Malignant                           1 (2%)       2 (3%)       2 (3%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  10                                                               
NTP Experiment-Test: 05026-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                            SODIUM AZIDE                                       Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 07:44:14  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     0 G/KG       5 MG/KG      10 MG/KG                                               
                                                   VEHICLEM     LOW MALE     HIGHMALE                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            59          58          50                                                   
     Total Primary Neoplasms                          173         159         103                                                   
                                                                                                                                    
   Total Animals with Benign Neoplasms                 58          57          49                                                   
     Total Benign Neoplasms                           129         119          79                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms              40          33          23                                                   
     Total Malignant Neoplasms                         44          40          24                                                   
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              4           2           3                                                   
     Total Metastatic Neoplasm                         10           4           4                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  11                                                               
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NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.