https://ntp.niehs.nih.gov/go/3770

TR 389 Rat Pathology Tables

NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Microbiological Assoc.                                   SODIUM AZIDE                                     DATE: 09/04/94       
EXPERIMENT: 05026 TEST: 01                                                                                     TIME: 07:56:00       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                   PAGE:       1        
CONT: N01C09565001          ROUTE: GAVAGE                                                                      NTP C#: 06462        
PATHOLOGIST: G. PARKER                                                                                         CAS: 26628228        
------------------------------------------------------------------------------------------------------------------------------------
               REASONS FOR REMOVAL:    ALL                                                                                          
               REMOVAL DATE RANGE:     ALL                                                                                          
               TREATMENT GROUPS:       INCLUDE ALL                                                                                  
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08    
LAB: Microbiological Assoc.                                   SODIUM AZIDE                                     DATE: 09/04/94      
EXPERIMENT: 05026 TEST: 01                                                                                     TIME: 07:56:00      
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                       
CONT: N01C09565001          ROUTE: GAVAGE                                                                      NTP C#: 06462       
PATHOLOGIST: G. PARKER                                                                                         CAS: 26628228       
                                                    RATS(FISCHER344)
                                              ----------------------------
             FOR ALL DOSES THE TUMOR RATES IN THE FOLLOWING TISSUES/ORGANS ARE BASED ON NUMBER OF TISSUES EXAMINED.
             IN OTHER TISSUES/ORGANS, RATES ARE BASED ON NUMBER OF ANIMALS NECROPSIED.
                                                    ----------------
                                                    Adrenal Gland
                                                    Bone Marrow
                                                    Brain
                                                    Clitoral Gland
                                                    Epididymis
                                                    Heart
                                                    Islets, Pancreatic
                                                    Kidney
                                                    Liver
                                                    Lung
                                                    Nose
                                                    Ovary
                                                    Pancreas
                                                    Parathyroid Gland
                                                    Pituitary Gland
                                                    Preputial Gland
                                                    Prostate
                                                    Salivary Glands
                                                    Spleen
                                                    Testes
                                                    Thymus
                                                    Thyroid Gland
                                                    Urinary Bladder
NTP                                        STATISTICAL ANALYSIS OF PRIMARY TUMORS                              REPORT: PEIRPT08     
LAB: Microbiological Assoc.                                   SODIUM AZIDE                                     DATE: 09/04/94       
EXPERIMENT: 05026 TEST: 01                                                                                     TIME: 07:56:00       
TEST TYPE:  CHRONIC                             CAGES FROM 0000 TO LAST CAGE                                                        
CONT: N01C09565001          ROUTE: GAVAGE                                                                      NTP C#: 06462        
PATHOLOGIST: G. PARKER                                                                                         CAS: 26628228        
                                     SUMMARY OF STATISTICALLY SIGNIFICANT (P<=.05) RESULTS
                                          IN THE ANALYSIS OF THE STUDY OF SODIUM AZIDE
              ====================================================================================================
                                                           MALE RATS
                                                          -------------
                                 ORGAN                               MORPHOLOGY
                                -------                             ------------
                             Adrenal Medulla               Pheochromocytoma Benign
                                                           Pheochromocytoma: Benign, Complex, Malignant, NOS
                             Mammary Gland                 Fibroma, Fibroadenoma or Adenoma
                                                           Fibroma, Fibroadenoma, Carcinoma, or Adenoma
                             Testes                        Adenoma
                             Zymbal's Gland                Carcinoma
                             All Organs                    Leukemia: Lymphocytic, Monocytic, Mononuclear,
                                                            or Undifferentiated
                                                           Osteosarcoma
                                                           Osteosarcoma or Osteoma
                                                           Benign Tumors
                                                           Malignant Tumors
                                                           Malignant and Benign Tumors
              ====================================================================================================
                                                           FEMALE RATS
                                                          -------------
                                 ORGAN                               MORPHOLOGY
                                -------                             ------------
                             Mammary Gland                 Fibroadenoma
                                                           Fibroma, Fibroadenoma or Adenoma
                                                           Fibroma, Fibroadenoma, Carcinoma, or Adenoma
                             Pituitary Gland: Pars Distalis or Unspecified Site
                                                           Adenoma
                                                           Carcinoma or Adenoma
                             Skin: Subcutaneous Tissue     Neurofibrosarcoma, Fibrosarcoma, Sarcoma,
                                                            Neurofibroma, or Fibroma
                             All Organs                    Benign Tumors
                                                           Malignant and Benign Tumors
              ====================================================================================================
         DATE: 09/04/94                     EXPERIMENT: 05026 TEST: 01                                                 PAGE   1
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- SODIUM AZIDE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      0 G/KG          5 MG/KG         10 MG/KG      |      0 G/KG          5 MG/KG         10MG/KG       |
|                       |      VEHICLEM        LOW MALE        HIGHMALE      |      VEHICLEF        LOW FEMA        HIGH FEM      |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Cortex                                                                                                                   |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     0/60 (0%)       0/60 (0%)       0/60 (0%)      |     1/60 (2%)       2/60 (3%)       0/58 (0%)      |
|ADJUSTED (b)           |      0.0%            0.0%            0.0%          |      2.3%            4.7%            0.0%          |
|TERMINAL (d)           |     0/24 (0%)       0/27 (0%)       0/9 (0%)       |     0/37 (0%)       2/43 (5%)       0/20 (0%)      |
|FIRST INCIDENCE (DAYS) |      ---             ---             ---           |      684             729 (T)         ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |       (e)             (e)             (e)          |     P=0.500N        P=0.554         P=0.616N       |
|INCIDENTAL TUMOR       |       (e)             (e)             (e)          |     P=0.400N        P=0.547         P=0.398N       |
|LOGISTIC REGRESSION    |       (e)             (e)             (e)          |     P=0.456N        P=0.540         P=0.556N       |
|COCHRAN-ARMITAGE       |       (e)                                          |     P=0.369N                                       |
|FISHER EXACT           |                       (e)             (e)          |                     P=0.500         P=0.508N       |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Pheochromocytoma Benign                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |    25/55 (45%)     15/56 (27%)      4/54 (7%)      |     1/58 (2%)       4/54 (7%)       1/56 (2%)      |
|ADJUSTED (b)           |     70.5%           50.0%           35.6%          |      2.3%            9.5%            4.8%          |
|TERMINAL (d)           |    14/24 (58%)     11/25 (44%)      2/8 (25%)      |     0/36 (0%)       4/42 (10%)      1/21 (5%)      |
|FIRST INCIDENCE (DAYS) |      555             579             662           |      684             729 (T)         729 (T)       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.011N*       P=0.027N*       P=0.056N       |     P=0.407         P=0.231         P=0.631        |
|INCIDENTAL TUMOR       |     P<0.001N**      P=0.016N*       P<0.001N**     |     P=0.489         P=0.182         P=0.765        |
|LOGISTIC REGRESSION    |     P<0.001N**      P=0.015N*       P=0.002N**     |     P=0.441         P=0.199         P=0.690        |
|COCHRAN-ARMITAGE       |     P<0.001N**                                     |     P=0.586                                        |
|FISHER EXACT           |                     P=0.032N*       P<0.001N**     |                     P=0.160         P=0.743        |
|=================================================================================================================================|
         DATE: 09/04/94                     EXPERIMENT: 05026 TEST: 01                                                 PAGE   2
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- SODIUM AZIDE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      0 G/KG          5 MG/KG         10 MG/KG      |      0 G/KG          5 MG/KG         10MG/KG       |
|                       |      VEHICLEM        LOW MALE        HIGHMALE      |      VEHICLEF        LOW FEMA        HIGH FEM      |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Pheochromocytoma Malignant                                                                                                  |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     1/55 (2%)       1/56 (2%)       2/54 (4%)      |     0/58 (0%)       1/54 (2%)       0/56 (0%)      |
|ADJUSTED (b)           |      4.2%            4.0%           19.8%          |      0.0%            2.4%            0.0%          |
|TERMINAL (d)           |     1/24 (4%)       1/25 (4%)       1/8 (13%)      |     0/36 (0%)       1/42 (2%)       0/21 (0%)      |
|FIRST INCIDENCE (DAYS) |      729 (T)         729 (T)         681           |      ---             729 (T)         ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.118         P=0.754N        P=0.154        |     P=0.680         P=0.531           (e)          |
|INCIDENTAL TUMOR       |     P=0.194         P=0.754N        P=0.293        |     P=0.680         P=0.531           (e)          |
|LOGISTIC REGRESSION    |     P=0.159         P=0.754N        P=0.229        |     P=0.680         P=0.531           (e)          |
|COCHRAN-ARMITAGE       |     P=0.372                                        |     P=0.724                                        |
|FISHER EXACT           |                     P=0.748N        P=0.493        |                     P=0.482           (e)          |
|=================================================================================================================================|
|                                                                                                                                 |
|Adrenal Medulla                                                                                                                  |
|     Pheochromocytoma: Benign, Complex, Malignant, NOS                                                                           |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |    26/55 (47%)     16/56 (29%)      6/54 (11%)     |     1/58 (2%)       5/54 (9%)       1/56 (2%)      |
|ADJUSTED (b)           |     73.4%           53.6%           50.8%          |      2.3%           11.9%            4.8%          |
|TERMINAL (d)           |    15/24 (63%)     12/25 (48%)      3/8 (38%)      |     0/36 (0%)       5/42 (12%)      1/21 (5%)      |
|FIRST INCIDENCE (DAYS) |      555             579             662           |      684             729 (T)         729 (T)       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.041N*       P=0.026N*       P=0.169N       |     P=0.383         P=0.144         P=0.631        |
|INCIDENTAL TUMOR       |     P<0.001N**      P=0.015N*       P=0.001N**     |     P=0.459         P=0.111         P=0.765        |
|LOGISTIC REGRESSION    |     P=0.003N**      P=0.014N*       P=0.010N*      |     P=0.413         P=0.120         P=0.690        |
|COCHRAN-ARMITAGE       |     P<0.001N**                                     |     P=0.577                                        |
|FISHER EXACT           |                     P=0.033N*       P<0.001N**     |                     P=0.087         P=0.743        |
|=================================================================================================================================|
         DATE: 09/04/94                     EXPERIMENT: 05026 TEST: 01                                                 PAGE   3
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- SODIUM AZIDE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      0 G/KG          5 MG/KG         10 MG/KG      |      0 G/KG          5 MG/KG         10MG/KG       |
|                       |      VEHICLEM        LOW MALE        HIGHMALE      |      VEHICLEF        LOW FEMA        HIGH FEM      |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral/Preputial Gland                                                                                                         |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     7/59 (12%)      9/59 (15%)      3/55 (5%)      |     4/55 (7%)       2/57 (4%)       5/49 (10%)     |
|ADJUSTED (b)           |     21.3%           26.7%           18.4%          |     10.4%            4.0%           21.7%          |
|TERMINAL (d)           |     3/24 (13%)      6/27 (22%)      1/9 (11%)      |     2/34 (6%)       1/42 (2%)       4/20 (20%)     |
|FIRST INCIDENCE (DAYS) |      495             502             649           |      684             502             449           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.543N        P=0.461         P=0.582N       |     P=0.210         P=0.260N        P=0.215        |
|INCIDENTAL TUMOR       |     P=0.235N        P=0.501         P=0.267N       |     P=0.415         P=0.312N        P=0.412        |
|LOGISTIC REGRESSION    |     P=0.276N        P=0.394         P=0.321N       |     P=0.353         P=0.325N        P=0.366        |
|COCHRAN-ARMITAGE       |     P=0.180N                                       |     P=0.362                                        |
|FISHER EXACT           |                     P=0.394         P=0.191N       |                     P=0.323N        P=0.426        |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral/Preputial Gland                                                                                                         |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     0/59 (0%)       1/59 (2%)       0/55 (0%)      |     1/55 (2%)       2/57 (4%)       0/49 (0%)      |
|ADJUSTED (b)           |      0.0%            3.6%            0.0%          |      2.0%            4.0%            0.0%          |
|TERMINAL (d)           |     0/24 (0%)       0/27 (0%)       0/9 (0%)       |     0/34 (0%)       1/42 (2%)       0/20 (0%)      |
|FIRST INCIDENCE (DAYS) |      ---             723             ---           |      594             453             ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.636         P=0.523           (e)          |     P=0.434N        P=0.545         P=0.550N       |
|INCIDENTAL TUMOR       |     P=0.720N        P=0.489           (e)          |     P=0.348N        P=0.445         P=0.536N       |
|LOGISTIC REGRESSION    |     P=0.645         P=0.520           (e)          |     P=0.355N        P=0.348         P=0.504N       |
|COCHRAN-ARMITAGE       |     P=0.722                                        |     P=0.389N                                       |
|FISHER EXACT           |                     P=0.500           (e)          |                     P=0.514         P=0.529N       |
|=================================================================================================================================|
         DATE: 09/04/94                     EXPERIMENT: 05026 TEST: 01                                                 PAGE   4
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- SODIUM AZIDE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      0 G/KG          5 MG/KG         10 MG/KG      |      0 G/KG          5 MG/KG         10MG/KG       |
|                       |      VEHICLEM        LOW MALE        HIGHMALE      |      VEHICLEF        LOW FEMA        HIGH FEM      |
|=================================================================================================================================|
|                                                                                                                                 |
|Clitoral/Preputial Gland                                                                                                         |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     7/59 (12%)     10/59 (17%)      3/55 (5%)      |     5/55 (9%)       4/57 (7%)       5/49 (10%)     |
|ADJUSTED (b)           |     21.3%           29.3%           18.4%          |     12.2%            7.9%           21.7%          |
|TERMINAL (d)           |     3/24 (13%)      6/27 (22%)      1/9 (11%)      |     2/34 (6%)       2/42 (5%)       4/20 (20%)     |
|FIRST INCIDENCE (DAYS) |      495             502             649           |      594             453             449           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.552         P=0.369         P=0.582N       |     P=0.327         P=0.399N        P=0.326        |
|INCIDENTAL TUMOR       |     P=0.240N        P=0.393         P=0.267N       |     P=0.568N        P=0.509N        P=0.540        |
|LOGISTIC REGRESSION    |     P=0.301N        P=0.301         P=0.321N       |     P=0.513         P=0.575N        P=0.514        |
|COCHRAN-ARMITAGE       |     P=0.187N                                       |     P=0.497                                        |
|FISHER EXACT           |                     P=0.301         P=0.191N       |                     P=0.477N        P=0.554        |
|=================================================================================================================================|
|                                                                                                                                 |
|Islets, Pancreatic                                                                                                               |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     3/59 (5%)       2/60 (3%)       1/60 (2%)      |     1/60 (2%)       1/60 (2%)       0/58 (0%)      |
|ADJUSTED (b)           |     10.6%            5.8%            2.2%          |      2.7%            2.3%            0.0%          |
|TERMINAL (d)           |     2/24 (8%)       1/27 (4%)       0/9 (0%)       |     1/37 (3%)       1/43 (2%)       0/21 (0%)      |
|FIRST INCIDENCE (DAYS) |      658             641             466           |      729 (T)         729 (T)         ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.411N        P=0.455N        P=0.563N       |     P=0.430N        P=0.728N        P=0.613N       |
|INCIDENTAL TUMOR       |     P=0.262N        P=0.499N        P=0.352N       |     P=0.430N        P=0.728N        P=0.613N       |
|LOGISTIC REGRESSION    |     P=0.256N        P=0.484N        P=0.349N       |     P=0.430N        P=0.728N        P=0.613N       |
|COCHRAN-ARMITAGE       |     P=0.217N                                       |     P=0.338N                                       |
|FISHER EXACT           |                     P=0.492N        P=0.303N       |                     P=0.752N        P=0.508N       |
|=================================================================================================================================|
         DATE: 09/04/94                     EXPERIMENT: 05026 TEST: 01                                                 PAGE   5
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- SODIUM AZIDE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      0 G/KG          5 MG/KG         10 MG/KG      |      0 G/KG          5 MG/KG         10MG/KG       |
|                       |      VEHICLEM        LOW MALE        HIGHMALE      |      VEHICLEF        LOW FEMA        HIGH FEM      |
|=================================================================================================================================|
|                                                                                                                                 |
|Islets, Pancreatic                                                                                                               |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     2/59 (3%)       2/60 (3%)       0/60 (0%)      |     0/60 (0%)       0/60 (0%)       0/58 (0%)      |
|ADJUSTED (b)           |      7.0%            6.4%            0.0%          |      0.0%            0.0%            0.0%          |
|TERMINAL (d)           |     0/24 (0%)       1/27 (4%)       0/9 (0%)       |     0/37 (0%)       0/43 (0%)       0/21 (0%)      |
|FIRST INCIDENCE (DAYS) |      703             693             ---           |      ---             ---             ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.372N        P=0.652N        P=0.483N       |       (e)             (e)             (e)          |
|INCIDENTAL TUMOR       |     P=0.194N        P=0.691         P=0.214N       |       (e)             (e)             (e)          |
|LOGISTIC REGRESSION    |     P=0.294N        P=0.675N        P=0.389N       |       (e)             (e)             (e)          |
|COCHRAN-ARMITAGE       |     P=0.173N                                       |       (e)                                          |
|FISHER EXACT           |                     P=0.684N        P=0.244N       |                       (e)             (e)          |
|=================================================================================================================================|
|                                                                                                                                 |
|Islets, Pancreatic                                                                                                               |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     5/59 (8%)       4/60 (7%)       1/60 (2%)      |     1/60 (2%)       1/60 (2%)       0/58 (0%)      |
|ADJUSTED (b)           |     16.9%           12.0%            2.2%          |      2.7%            2.3%            0.0%          |
|TERMINAL (d)           |     2/24 (8%)       2/27 (7%)       0/9 (0%)       |     1/37 (3%)       1/43 (2%)       0/21 (0%)      |
|FIRST INCIDENCE (DAYS) |      658             641             466           |      729 (T)         729 (T)         ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.274N        P=0.437N        P=0.367N       |     P=0.430N        P=0.728N        P=0.613N       |
|INCIDENTAL TUMOR       |     P=0.103N        P=0.503N        P=0.108N       |     P=0.430N        P=0.728N        P=0.613N       |
|LOGISTIC REGRESSION    |     P=0.134N        P=0.473N        P=0.164N       |     P=0.430N        P=0.728N        P=0.613N       |
|COCHRAN-ARMITAGE       |     P=0.078N                                       |     P=0.338N                                       |
|FISHER EXACT           |                     P=0.489N        P=0.100N       |                     P=0.752N        P=0.508N       |
|=================================================================================================================================|
         DATE: 09/04/94                     EXPERIMENT: 05026 TEST: 01                                                 PAGE   6
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- SODIUM AZIDE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      0 G/KG          5 MG/KG         10 MG/KG      |      0 G/KG          5 MG/KG         10MG/KG       |
|                       |      VEHICLEM        LOW MALE        HIGHMALE      |      VEHICLEF        LOW FEMA        HIGH FEM      |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney: Renal Tubule                                                                                                             |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     2/60 (3%)       1/60 (2%)       1/60 (2%)      |     0/60 (0%)       0/60 (0%)       0/59 (0%)      |
|ADJUSTED (b)           |      8.3%            3.7%            3.4%          |      0.0%            0.0%            0.0%          |
|TERMINAL (d)           |     2/24 (8%)       1/27 (4%)       0/9 (0%)       |     0/37 (0%)       0/43 (0%)       0/21 (0%)      |
|FIRST INCIDENCE (DAYS) |      729 (T)         729 (T)         645           |      ---             ---             ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.601N        P=0.459N        P=0.717        |       (e)             (e)             (e)          |
|INCIDENTAL TUMOR       |     P=0.559N        P=0.459N        P=0.705N       |       (e)             (e)             (e)          |
|LOGISTIC REGRESSION    |     P=0.558N        P=0.459N        P=0.709N       |       (e)             (e)             (e)          |
|COCHRAN-ARMITAGE       |     P=0.378N                                       |       (e)                                          |
|FISHER EXACT           |                     P=0.500N        P=0.500N       |                       (e)             (e)          |
|=================================================================================================================================|
|                                                                                                                                 |
|Kidney: Renal Tubule                                                                                                             |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     2/60 (3%)       1/60 (2%)       1/60 (2%)      |     0/60 (0%)       0/60 (0%)       1/59 (2%)      |
|ADJUSTED (b)           |      8.3%            3.7%            3.4%          |      0.0%            0.0%            2.7%          |
|TERMINAL (d)           |     2/24 (8%)       1/27 (4%)       0/9 (0%)       |     0/37 (0%)       0/43 (0%)       0/21 (0%)      |
|FIRST INCIDENCE (DAYS) |      729 (T)         729 (T)         645           |      ---             ---             642           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.601N        P=0.459N        P=0.717        |     P=0.231           (e)           P=0.452        |
|INCIDENTAL TUMOR       |     P=0.559N        P=0.459N        P=0.705N       |     P=0.233           (e)           P=0.433        |
|LOGISTIC REGRESSION    |     P=0.558N        P=0.459N        P=0.709N       |     P=0.262           (e)           P=0.480        |
|COCHRAN-ARMITAGE       |     P=0.378N                                       |     P=0.267                                        |
|FISHER EXACT           |                     P=0.500N        P=0.500N       |                       (e)           P=0.496        |
|=================================================================================================================================|
         DATE: 09/04/94                     EXPERIMENT: 05026 TEST: 01                                                 PAGE   7
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- SODIUM AZIDE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      0 G/KG          5 MG/KG         10 MG/KG      |      0 G/KG          5 MG/KG         10MG/KG       |
|                       |      VEHICLEM        LOW MALE        HIGHMALE      |      VEHICLEF        LOW FEMA        HIGH FEM      |
|=================================================================================================================================|
|                                                                                                                                 |
|Liver                                                                                                                            |
|     Hepatocellular Adenoma                                                                                                      |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     3/60 (5%)       3/60 (5%)       0/60 (0%)      |     1/60 (2%)       0/60 (0%)       0/59 (0%)      |
|ADJUSTED (b)           |     11.5%            8.8%            0.0%          |      2.7%            0.0%            0.0%          |
|TERMINAL (d)           |     2/24 (8%)       1/27 (4%)       0/9 (0%)       |     1/37 (3%)       0/43 (0%)       0/21 (0%)      |
|FIRST INCIDENCE (DAYS) |      703             632             ---           |      729 (T)         ---             ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.254N        P=0.602N        P=0.345N       |     P=0.322N        P=0.470N        P=0.613N       |
|INCIDENTAL TUMOR       |     P=0.169N        P=0.652         P=0.236N       |     P=0.322N        P=0.470N        P=0.613N       |
|LOGISTIC REGRESSION    |     P=0.201N        P=0.644N        P=0.309N       |     P=0.322N        P=0.470N        P=0.613N       |
|COCHRAN-ARMITAGE       |     P=0.102N                                       |     P=0.272N                                       |
|FISHER EXACT           |                     P=0.660N        P=0.122N       |                     P=0.500N        P=0.504N       |
|=================================================================================================================================|
|                                                                                                                                 |
|Lung                                                                                                                             |
|     Alveolar/Bronchiolar Carcinoma or Alveolar/Bronchiolar Adenoma                                                              |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     2/60 (3%)       1/60 (2%)       0/60 (0%)      |     0/60 (0%)       1/60 (2%)       0/59 (0%)      |
|ADJUSTED (b)           |      5.9%            3.7%            0.0%          |      0.0%            2.3%            0.0%          |
|TERMINAL (d)           |     1/24 (4%)       1/27 (4%)       0/9 (0%)       |     0/37 (0%)       1/43 (2%)       0/21 (0%)      |
|FIRST INCIDENCE (DAYS) |      555             729 (T)         ---           |      ---             729 (T)         ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.235N        P=0.477N        P=0.380N       |     P=0.678         P=0.530           (e)          |
|INCIDENTAL TUMOR       |     P=0.228N        P=0.515N        P=0.353N       |     P=0.678         P=0.530           (e)          |
|LOGISTIC REGRESSION    |     P=0.169N        P=0.499N        P=0.258N       |     P=0.678         P=0.530           (e)          |
|COCHRAN-ARMITAGE       |     P=0.142N                                       |     P=0.728                                        |
|FISHER EXACT           |                     P=0.500N        P=0.248N       |                     P=0.500           (e)          |
|=================================================================================================================================|
         DATE: 09/04/94                     EXPERIMENT: 05026 TEST: 01                                                 PAGE   8
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- SODIUM AZIDE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      0 G/KG          5 MG/KG         10 MG/KG      |      0 G/KG          5 MG/KG         10MG/KG       |
|                       |      VEHICLEM        LOW MALE        HIGHMALE      |      VEHICLEF        LOW FEMA        HIGH FEM      |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     1/60 (2%)       0/60 (0%)       0/60 (0%)      |     2/60 (3%)       0/60 (0%)       0/59 (0%)      |
|ADJUSTED (b)           |      4.2%            0.0%            0.0%          |      4.8%            0.0%            0.0%          |
|TERMINAL (d)           |     1/24 (4%)       0/27 (0%)       0/9 (0%)       |     1/37 (3%)       0/43 (0%)       0/21 (0%)      |
|FIRST INCIDENCE (DAYS) |      729 (T)         ---             ---           |      649             ---             ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.360N        P=0.477N        P=0.695N       |     P=0.124N        P=0.210N        P=0.346N       |
|INCIDENTAL TUMOR       |     P=0.360N        P=0.477N        P=0.695N       |     P=0.085N        P=0.212N        P=0.238N       |
|LOGISTIC REGRESSION    |     P=0.360N        P=0.477N        P=0.695N       |     P=0.106N        P=0.232N        P=0.296N       |
|COCHRAN-ARMITAGE       |     P=0.270N                                       |     P=0.097N                                       |
|FISHER EXACT           |                     P=0.500N        P=0.500N       |                     P=0.248N        P=0.252N       |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     0/60 (0%)       0/60 (0%)       0/60 (0%)      |     2/60 (3%)       1/60 (2%)       3/59 (5%)      |
|ADJUSTED (b)           |      0.0%            0.0%            0.0%          |      4.5%            2.3%           11.2%          |
|TERMINAL (d)           |     0/24 (0%)       0/27 (0%)       0/9 (0%)       |     1/37 (3%)       1/43 (2%)       1/21 (5%)      |
|FIRST INCIDENCE (DAYS) |      ---             ---             ---           |      488             729 (T)         502           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |       (e)             (e)             (e)          |     P=0.248         P=0.457N        P=0.319        |
|INCIDENTAL TUMOR       |       (e)             (e)             (e)          |     P=0.445         P=0.498N        P=0.569        |
|LOGISTIC REGRESSION    |       (e)             (e)             (e)          |     P=0.389         P=0.562N        P=0.472        |
|COCHRAN-ARMITAGE       |       (e)                                          |     P=0.393                                        |
|FISHER EXACT           |                       (e)             (e)          |                     P=0.500N        P=0.492        |
|=================================================================================================================================|
         DATE: 09/04/94                     EXPERIMENT: 05026 TEST: 01                                                 PAGE   9
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- SODIUM AZIDE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      0 G/KG          5 MG/KG         10 MG/KG      |      0 G/KG          5 MG/KG         10MG/KG       |
|                       |      VEHICLEM        LOW MALE        HIGHMALE      |      VEHICLEF        LOW FEMA        HIGH FEM      |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     1/60 (2%)       0/60 (0%)       0/60 (0%)      |     4/60 (7%)       1/60 (2%)       3/59 (5%)      |
|ADJUSTED (b)           |      4.2%            0.0%            0.0%          |      9.1%            2.3%           11.2%          |
|TERMINAL (d)           |     1/24 (4%)       0/27 (0%)       0/9 (0%)       |     2/37 (5%)       1/43 (2%)       1/21 (5%)      |
|FIRST INCIDENCE (DAYS) |      729 (T)         ---             ---           |      488             729 (T)         502           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.360N        P=0.477N        P=0.695N       |     P=0.590         P=0.147N        P=0.581        |
|INCIDENTAL TUMOR       |     P=0.360N        P=0.477N        P=0.695N       |     P=0.366N        P=0.167N        P=0.445N       |
|LOGISTIC REGRESSION    |     P=0.360N        P=0.477N        P=0.695N       |     P=0.439N        P=0.203N        P=0.565N       |
|COCHRAN-ARMITAGE       |     P=0.270N                                       |     P=0.420N                                       |
|FISHER EXACT           |                     P=0.500N        P=0.500N       |                     P=0.182N        P=0.509N       |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Fibroadenoma                                                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     2/60 (3%)       0/60 (0%)       0/60 (0%)      |    20/60 (33%)     11/60 (18%)      8/59 (14%)     |
|ADJUSTED (b)           |      8.3%            0.0%            0.0%          |     47.0%           24.9%           27.3%          |
|TERMINAL (d)           |     2/24 (8%)       0/27 (0%)       0/9 (0%)       |    15/37 (41%)     10/43 (23%)      4/21 (19%)     |
|FIRST INCIDENCE (DAYS) |      729 (T)         ---             ---           |      575             719             502           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.154N        P=0.212N        P=0.471N       |     P=0.080N        P=0.016N*       P=0.179N       |
|INCIDENTAL TUMOR       |     P=0.154N        P=0.212N        P=0.471N       |     P=0.030N*       P=0.022N*       P=0.059N       |
|LOGISTIC REGRESSION    |     P=0.154N        P=0.212N        P=0.471N       |     P=0.030N*       P=0.017N*       P=0.060N       |
|COCHRAN-ARMITAGE       |     P=0.096N                                       |     P=0.006N**                                     |
|FISHER EXACT           |                     P=0.248N        P=0.248N       |                     P=0.047N*       P=0.009N**     |
|=================================================================================================================================|
         DATE: 09/04/94                     EXPERIMENT: 05026 TEST: 01                                                 PAGE  10
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- SODIUM AZIDE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      0 G/KG          5 MG/KG         10 MG/KG      |      0 G/KG          5 MG/KG         10MG/KG       |
|                       |      VEHICLEM        LOW MALE        HIGHMALE      |      VEHICLEF        LOW FEMA        HIGH FEM      |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Fibroma, Fibroadenoma or Adenoma                                                                                            |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     3/60 (5%)       0/60 (0%)       0/60 (0%)      |    21/60 (35%)     11/60 (18%)      8/59 (14%)     |
|ADJUSTED (b)           |     12.5%            0.0%            0.0%          |     48.1%           24.9%           27.3%          |
|TERMINAL (d)           |     3/24 (13%)      0/27 (0%)       0/9 (0%)       |    15/37 (41%)     10/43 (23%)      4/21 (19%)     |
|FIRST INCIDENCE (DAYS) |      729 (T)         ---             ---           |      575             719             502           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.070N        P=0.099N        P=0.335N       |     P=0.056N        P=0.010N*       P=0.141N       |
|INCIDENTAL TUMOR       |     P=0.070N        P=0.099N        P=0.335N       |     P=0.017N*       P=0.013N*       P=0.034N*      |
|LOGISTIC REGRESSION    |     P=0.070N        P=0.099N        P=0.335N       |     P=0.018N*       P=0.011N*       P=0.040N*      |
|COCHRAN-ARMITAGE       |     P=0.037N*                                      |     P=0.003N**                                     |
|FISHER EXACT           |                     P=0.122N        P=0.122N       |                     P=0.031N*       P=0.006N**     |
|=================================================================================================================================|
|                                                                                                                                 |
|Mammary Gland                                                                                                                    |
|     Fibroma, Fibroadenoma, Carcinoma, or Adenoma                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     3/60 (5%)       0/60 (0%)       0/60 (0%)      |    22/60 (37%)     12/60 (20%)     11/59 (19%)     |
|ADJUSTED (b)           |     12.5%            0.0%            0.0%          |     49.1%           27.1%           36.2%          |
|TERMINAL (d)           |     3/24 (13%)      0/27 (0%)       0/9 (0%)       |    15/37 (41%)     11/43 (26%)      5/21 (24%)     |
|FIRST INCIDENCE (DAYS) |      729 (T)         ---             ---           |      488             719             502           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.070N        P=0.099N        P=0.335N       |     P=0.179N        P=0.011N*       P=0.326N       |
|INCIDENTAL TUMOR       |     P=0.070N        P=0.099N        P=0.335N       |     P=0.048N*       P=0.016N*       P=0.074N       |
|LOGISTIC REGRESSION    |     P=0.070N        P=0.099N        P=0.335N       |     P=0.058N        P=0.015N*       P=0.101N       |
|COCHRAN-ARMITAGE       |     P=0.037N*                                      |     P=0.015N*                                      |
|FISHER EXACT           |                     P=0.122N        P=0.122N       |                     P=0.034N*       P=0.023N*      |
|=================================================================================================================================|
         DATE: 09/04/94                     EXPERIMENT: 05026 TEST: 01                                                 PAGE  11
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- SODIUM AZIDE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      0 G/KG          5 MG/KG         10 MG/KG      |      0 G/KG          5 MG/KG         10MG/KG       |
|                       |      VEHICLEM        LOW MALE        HIGHMALE      |      VEHICLEF        LOW FEMA        HIGH FEM      |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |    23/59 (39%)     23/60 (38%)     15/60 (25%)     |    35/60 (58%)     27/60 (45%)     17/59 (29%)     |
|ADJUSTED (b)           |     65.2%           58.7%           56.9%          |     73.9%           52.2%           60.1%          |
|TERMINAL (d)           |    13/24 (54%)     13/27 (48%)      2/9 (22%)      |    25/37 (68%)     19/43 (44%)     11/21 (52%)     |
|FIRST INCIDENCE (DAYS) |      495             502             432           |      429             453             502           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.206         P=0.428N        P=0.156        |     P=0.124N        P=0.030N*       P=0.225N       |
|INCIDENTAL TUMOR       |     P=0.199N        P=0.452N        P=0.198N       |     P=0.008N**      P=0.049N*       P=0.014N*      |
|LOGISTIC REGRESSION    |     P=0.270N        P=0.536N        P=0.359N       |     P=0.010N*       P=0.056N        P=0.020N*      |
|COCHRAN-ARMITAGE       |     P=0.065N                                       |     P<0.001N**                                     |
|FISHER EXACT           |                     P=0.546N        P=0.075N       |                     P=0.100N        P=0.001N**     |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     0/59 (0%)       0/60 (0%)       0/60 (0%)      |     2/60 (3%)       1/60 (2%)       0/59 (0%)      |
|ADJUSTED (b)           |      0.0%            0.0%            0.0%          |      4.9%            2.0%            0.0%          |
|TERMINAL (d)           |     0/24 (0%)       0/27 (0%)       0/9 (0%)       |     0/37 (0%)       0/43 (0%)       0/21 (0%)      |
|FIRST INCIDENCE (DAYS) |      ---             ---             ---           |      693             684             ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |       (e)             (e)             (e)          |     P=0.213N        P=0.434N        P=0.384N       |
|INCIDENTAL TUMOR       |       (e)             (e)             (e)          |     P=0.071N        P=0.461N        P=0.131N       |
|LOGISTIC REGRESSION    |       (e)             (e)             (e)          |     P=0.172N        P=0.482N        P=0.316N       |
|COCHRAN-ARMITAGE       |       (e)                                          |     P=0.145N                                       |
|FISHER EXACT           |                       (e)             (e)          |                     P=0.500N        P=0.252N       |
|=================================================================================================================================|
         DATE: 09/04/94                     EXPERIMENT: 05026 TEST: 01                                                 PAGE  12
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- SODIUM AZIDE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      0 G/KG          5 MG/KG         10 MG/KG      |      0 G/KG          5 MG/KG         10MG/KG       |
|                       |      VEHICLEM        LOW MALE        HIGHMALE      |      VEHICLEF        LOW FEMA        HIGH FEM      |
|=================================================================================================================================|
|                                                                                                                                 |
|Pituitary Gland: Pars Distalis or Unspecified Site                                                                               |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |    23/59 (39%)     23/60 (38%)     15/60 (25%)     |    37/60 (62%)     28/60 (47%)     17/59 (29%)     |
|ADJUSTED (b)           |     65.2%           58.7%           56.9%          |     75.2%           53.2%           60.1%          |
|TERMINAL (d)           |    13/24 (54%)     13/27 (48%)      2/9 (22%)      |    25/37 (68%)     19/43 (44%)     11/21 (52%)     |
|FIRST INCIDENCE (DAYS) |      495             502             432           |      429             453             502           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.206         P=0.428N        P=0.156        |     P=0.081N        P=0.022N*       P=0.161N       |
|INCIDENTAL TUMOR       |     P=0.199N        P=0.452N        P=0.198N       |     P=0.002N**      P=0.029N*       P=0.003N**     |
|LOGISTIC REGRESSION    |     P=0.270N        P=0.536N        P=0.359N       |     P=0.004N**      P=0.036N*       P=0.008N**     |
|COCHRAN-ARMITAGE       |     P=0.065N                                       |     P<0.001N**                                     |
|FISHER EXACT           |                     P=0.546N        P=0.075N       |                     P=0.071N        P<0.001N**     |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Squamous Cell Carcinoma                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     2/60 (3%)       0/60 (0%)       0/60 (0%)      |     0/60 (0%)       0/60 (0%)       0/59 (0%)      |
|ADJUSTED (b)           |      6.6%            0.0%            0.0%          |      0.0%            0.0%            0.0%          |
|TERMINAL (d)           |     1/24 (4%)       0/27 (0%)       0/9 (0%)       |     0/37 (0%)       0/43 (0%)       0/21 (0%)      |
|FIRST INCIDENCE (DAYS) |      674             ---             ---           |      ---             ---             ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.160N        P=0.224N        P=0.468N       |       (e)             (e)             (e)          |
|INCIDENTAL TUMOR       |     P=0.118N        P=0.233N        P=0.327N       |       (e)             (e)             (e)          |
|LOGISTIC REGRESSION    |     P=0.128N        P=0.230N        P=0.373N       |       (e)             (e)             (e)          |
|COCHRAN-ARMITAGE       |     P=0.096N                                       |       (e)                                          |
|FISHER EXACT           |                     P=0.248N        P=0.248N       |                       (e)             (e)          |
|=================================================================================================================================|
         DATE: 09/04/94                     EXPERIMENT: 05026 TEST: 01                                                 PAGE  13
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- SODIUM AZIDE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      0 G/KG          5 MG/KG         10 MG/KG      |      0 G/KG          5 MG/KG         10MG/KG       |
|                       |      VEHICLEM        LOW MALE        HIGHMALE      |      VEHICLEF        LOW FEMA        HIGH FEM      |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Squamous Cell Carcinoma, Papilloma Squamous, or Papilloma                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     3/60 (5%)       0/60 (0%)       2/60 (3%)      |     0/60 (0%)       0/60 (0%)       0/59 (0%)      |
|ADJUSTED (b)           |      8.7%            0.0%            7.7%          |      0.0%            0.0%            0.0%          |
|TERMINAL (d)           |     1/24 (4%)       0/27 (0%)       0/9 (0%)       |     0/37 (0%)       0/43 (0%)       0/21 (0%)      |
|FIRST INCIDENCE (DAYS) |      633             ---             563           |      ---             ---             ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.596N        P=0.112N        P=0.583        |       (e)             (e)             (e)          |
|INCIDENTAL TUMOR       |     P=0.442N        P=0.141N        P=0.579N       |       (e)             (e)             (e)          |
|LOGISTIC REGRESSION    |     P=0.432N        P=0.120N        P=0.597N       |       (e)             (e)             (e)          |
|COCHRAN-ARMITAGE       |     P=0.391N                                       |       (e)                                          |
|FISHER EXACT           |                     P=0.122N        P=0.500N       |                       (e)             (e)          |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Squamous Cell Papilloma                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     1/60 (2%)       0/60 (0%)       2/60 (3%)      |     0/60 (0%)       0/60 (0%)       0/59 (0%)      |
|ADJUSTED (b)           |      2.3%            0.0%            7.7%          |      0.0%            0.0%            0.0%          |
|TERMINAL (d)           |     0/24 (0%)       0/27 (0%)       0/9 (0%)       |     0/37 (0%)       0/43 (0%)       0/21 (0%)      |
|FIRST INCIDENCE (DAYS) |      633             ---             563           |      ---             ---             ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.250         P=0.487N        P=0.347        |       (e)             (e)             (e)          |
|INCIDENTAL TUMOR       |     P=0.360         P=0.573N        P=0.494        |       (e)             (e)             (e)          |
|LOGISTIC REGRESSION    |     P=0.370         P=0.500N        P=0.491        |       (e)             (e)             (e)          |
|COCHRAN-ARMITAGE       |     P=0.361                                        |       (e)                                          |
|FISHER EXACT           |                     P=0.500N        P=0.500        |                       (e)             (e)          |
|=================================================================================================================================|
         DATE: 09/04/94                     EXPERIMENT: 05026 TEST: 01                                                 PAGE  14
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- SODIUM AZIDE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      0 G/KG          5 MG/KG         10 MG/KG      |      0 G/KG          5 MG/KG         10MG/KG       |
|                       |      VEHICLEM        LOW MALE        HIGHMALE      |      VEHICLEF        LOW FEMA        HIGH FEM      |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Trichoepithelioma                                                                                                           |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     2/60 (3%)       1/60 (2%)       0/60 (0%)      |     0/60 (0%)       0/60 (0%)       0/59 (0%)      |
|ADJUSTED (b)           |      8.3%            3.7%            0.0%          |      0.0%            0.0%            0.0%          |
|TERMINAL (d)           |     2/24 (8%)       1/27 (4%)       0/9 (0%)       |     0/37 (0%)       0/43 (0%)       0/21 (0%)      |
|FIRST INCIDENCE (DAYS) |      729 (T)         729 (T)         ---           |      ---             ---             ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.264N        P=0.459N        P=0.471N       |       (e)             (e)             (e)          |
|INCIDENTAL TUMOR       |     P=0.264N        P=0.459N        P=0.471N       |       (e)             (e)             (e)          |
|LOGISTIC REGRESSION    |     P=0.264N        P=0.459N        P=0.471N       |       (e)             (e)             (e)          |
|COCHRAN-ARMITAGE       |     P=0.142N                                       |       (e)                                          |
|FISHER EXACT           |                     P=0.500N        P=0.248N       |                       (e)             (e)          |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin                                                                                                                             |
|     Trichoepithelioma, Kertatocanthoma, Squamous Cell Carcinoma,                                                                |
|     Basal Cell Carcinoma or Adenoma, Papilloma Squamous, or Papilloma                                                           |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     6/60 (10%)      2/60 (3%)       3/60 (5%)      |     0/60 (0%)       0/60 (0%)       0/59 (0%)      |
|ADJUSTED (b)           |     18.1%            7.4%           10.9%          |      0.0%            0.0%            0.0%          |
|TERMINAL (d)           |     3/24 (13%)      2/27 (7%)       0/9 (0%)       |     0/37 (0%)       0/43 (0%)       0/21 (0%)      |
|FIRST INCIDENCE (DAYS) |      300             729 (T)         563           |      ---             ---             ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.423N        P=0.113N        P=0.595N       |       (e)             (e)             (e)          |
|INCIDENTAL TUMOR       |     P=0.231N        P=0.131N        P=0.312N       |       (e)             (e)             (e)          |
|LOGISTIC REGRESSION    |     P=0.194N        P=0.136N        P=0.269N       |       (e)             (e)             (e)          |
|COCHRAN-ARMITAGE       |     P=0.170N                                       |       (e)                                          |
|FISHER EXACT           |                     P=0.136N        P=0.245N       |                       (e)             (e)          |
|=================================================================================================================================|
         DATE: 09/04/94                     EXPERIMENT: 05026 TEST: 01                                                 PAGE  15
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- SODIUM AZIDE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      0 G/KG          5 MG/KG         10 MG/KG      |      0 G/KG          5 MG/KG         10MG/KG       |
|                       |      VEHICLEM        LOW MALE        HIGHMALE      |      VEHICLEF        LOW FEMA        HIGH FEM      |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin: Subcutaneous Tissue                                                                                                        |
|     Fibroma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     2/60 (3%)       5/60 (8%)       2/60 (3%)      |     4/60 (7%)       1/60 (2%)       1/59 (2%)      |
|ADJUSTED (b)           |      6.6%           14.6%           11.2%          |     10.0%            2.3%            3.4%          |
|TERMINAL (d)           |     1/24 (4%)       2/27 (7%)       0/9 (0%)       |     3/37 (8%)       1/43 (2%)       0/21 (0%)      |
|FIRST INCIDENCE (DAYS) |      658             640             617           |      596             729 (T)         654           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.251         P=0.267         P=0.412        |     P=0.179N        P=0.141N        P=0.347N       |
|INCIDENTAL TUMOR       |     P=0.472         P=0.209         P=0.624        |     P=0.154N        P=0.176N        P=0.279N       |
|LOGISTIC REGRESSION    |     P=0.405         P=0.227         P=0.577        |     P=0.136N        P=0.159N        P=0.263N       |
|COCHRAN-ARMITAGE       |     P=0.583                                        |     P=0.105N                                       |
|FISHER EXACT           |                     P=0.219         P=0.691N       |                     P=0.182N        P=0.187N       |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin: Subcutaneous Tissue                                                                                                        |
|     Neurofibrosarcoma, Fibrosarcoma, Sarcoma,                                                                                   |
|     Neurofibroma, or Fibroma                                                                                                    |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     2/60 (3%)       5/60 (8%)       3/60 (5%)      |     5/60 (8%)       1/60 (2%)       1/59 (2%)      |
|ADJUSTED (b)           |      6.6%           14.6%           21.1%          |     11.5%            2.3%            3.4%          |
|TERMINAL (d)           |     1/24 (4%)       2/27 (7%)       1/9 (11%)      |     3/37 (8%)       1/43 (2%)       0/21 (0%)      |
|FIRST INCIDENCE (DAYS) |      658             640             617           |      352             729 (T)         654           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.116         P=0.267         P=0.180        |     P=0.094N        P=0.080N        P=0.229N       |
|INCIDENTAL TUMOR       |     P=0.280         P=0.209         P=0.345        |     P=0.047N*       P=0.176N        P=0.112N       |
|LOGISTIC REGRESSION    |     P=0.224         P=0.227         P=0.310        |     P=0.044N*       P=0.142N        P=0.110N       |
|COCHRAN-ARMITAGE       |     P=0.421                                        |     P=0.051N                                       |
|FISHER EXACT           |                     P=0.219         P=0.500        |                     P=0.103N        P=0.107N       |
|=================================================================================================================================|
         DATE: 09/04/94                     EXPERIMENT: 05026 TEST: 01                                                 PAGE  16
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- SODIUM AZIDE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      0 G/KG          5 MG/KG         10 MG/KG      |      0 G/KG          5 MG/KG         10MG/KG       |
|                       |      VEHICLEM        LOW MALE        HIGHMALE      |      VEHICLEF        LOW FEMA        HIGH FEM      |
|=================================================================================================================================|
|                                                                                                                                 |
|Skin: Subcutaneous Tissue                                                                                                        |
|     Schwannoma Malignant                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     0/60 (0%)       0/60 (0%)       2/60 (3%)      |     0/60 (0%)       0/60 (0%)       0/59 (0%)      |
|ADJUSTED (b)           |      0.0%            0.0%            6.1%          |      0.0%            0.0%            0.0%          |
|TERMINAL (d)           |     0/24 (0%)       0/27 (0%)       0/9 (0%)       |     0/37 (0%)       0/43 (0%)       0/21 (0%)      |
|FIRST INCIDENCE (DAYS) |      ---             ---             569           |      ---             ---             ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.061           (e)           P=0.168        |       (e)             (e)             (e)          |
|INCIDENTAL TUMOR       |     P=0.105           (e)           P=0.242        |       (e)             (e)             (e)          |
|LOGISTIC REGRESSION    |     P=0.101           (e)           P=0.235        |       (e)             (e)             (e)          |
|COCHRAN-ARMITAGE       |     P=0.096                                        |       (e)                                          |
|FISHER EXACT           |                       (e)           P=0.248        |                       (e)             (e)          |
|=================================================================================================================================|
|                                                                                                                                 |
|Testes                                                                                                                           |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |    52/60 (87%)     51/60 (85%)     44/60 (73%)     |                                                    |
|ADJUSTED (b)           |    100.0%           96.2%          100.0%          |                                                    |
|TERMINAL (d)           |    24/24 (100%)    25/27 (93%)      9/9 (100%)     |                                                    |
|FIRST INCIDENCE (DAYS) |      495             437             341           |                                                    |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.002 **      P=0.271N        P=0.001 **     |                                                    |
|INCIDENTAL TUMOR       |     P=0.408         P=0.575N        P=0.458        |                                                    |
|LOGISTIC REGRESSION    |     P=0.425         P=0.532N        P=0.530        |                                                    |
|COCHRAN-ARMITAGE       |     P=0.038N*                                      |                                                    |
|FISHER EXACT           |                     P=0.500N        P=0.054N       |                                                    |
|=================================================================================================================================|
         DATE: 09/04/94                     EXPERIMENT: 05026 TEST: 01                                                 PAGE  17
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- SODIUM AZIDE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      0 G/KG          5 MG/KG         10 MG/KG      |      0 G/KG          5 MG/KG         10MG/KG       |
|                       |      VEHICLEM        LOW MALE        HIGHMALE      |      VEHICLEF        LOW FEMA        HIGH FEM      |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: C-Cell                                                                                                            |
|     Adenoma                                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     3/57 (5%)       7/58 (12%)      3/59 (5%)      |     3/60 (5%)       3/60 (5%)       3/56 (5%)      |
|ADJUSTED (b)           |     11.5%           23.9%           23.6%          |      8.1%            6.8%           14.3%          |
|TERMINAL (d)           |     2/23 (9%)       5/26 (19%)      2/9 (22%)      |     3/37 (8%)       2/43 (5%)       3/21 (14%)     |
|FIRST INCIDENCE (DAYS) |      694             648             341           |      729 (T)         728             729 (T)       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.168         P=0.207         P=0.277        |     P=0.334         P=0.587N        P=0.385        |
|INCIDENTAL TUMOR       |     P=0.344         P=0.187         P=0.482        |     P=0.389         P=0.595N        P=0.385        |
|LOGISTIC REGRESSION    |     P=0.242         P=0.191         P=0.578        |     P=0.333         P=0.568N        P=0.385        |
|COCHRAN-ARMITAGE       |     P=0.549N                                       |     P=0.550                                        |
|FISHER EXACT           |                     P=0.168         P=0.644N       |                     P=0.660N        P=0.627        |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: C-Cell                                                                                                            |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     0/57 (0%)       1/58 (2%)       0/59 (0%)      |     3/60 (5%)       1/60 (2%)       0/56 (0%)      |
|ADJUSTED (b)           |      0.0%            3.8%            0.0%          |      7.3%            2.3%            0.0%          |
|TERMINAL (d)           |     0/23 (0%)       1/26 (4%)       0/9 (0%)       |     2/37 (5%)       1/43 (2%)       0/21 (0%)      |
|FIRST INCIDENCE (DAYS) |      ---             729 (T)         ---           |      578             729 (T)         ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.644         P=0.524           (e)          |     P=0.096N        P=0.260N        P=0.216N       |
|INCIDENTAL TUMOR       |     P=0.644         P=0.524           (e)          |     P=0.108N        P=0.313N        P=0.221N       |
|LOGISTIC REGRESSION    |     P=0.644         P=0.524           (e)          |     P=0.077N        P=0.296N        P=0.165N       |
|COCHRAN-ARMITAGE       |     P=0.726N                                       |     P=0.067N                                       |
|FISHER EXACT           |                     P=0.504           (e)          |                     P=0.309N        P=0.135N       |
|=================================================================================================================================|
         DATE: 09/04/94                     EXPERIMENT: 05026 TEST: 01                                                 PAGE  18
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- SODIUM AZIDE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      0 G/KG          5 MG/KG         10 MG/KG      |      0 G/KG          5 MG/KG         10MG/KG       |
|                       |      VEHICLEM        LOW MALE        HIGHMALE      |      VEHICLEF        LOW FEMA        HIGH FEM      |
|=================================================================================================================================|
|                                                                                                                                 |
|Thyroid Gland: C-Cell                                                                                                            |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |                                                    |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     3/57 (5%)       8/58 (14%)      3/59 (5%)      |     6/60 (10%)      4/60 (7%)       3/56 (5%)      |
|ADJUSTED (b)           |     11.5%           27.5%           23.6%          |     15.2%            9.0%           14.3%          |
|TERMINAL (d)           |     2/23 (9%)       6/26 (23%)      2/9 (22%)      |     5/37 (14%)      3/43 (7%)       3/21 (14%)     |
|FIRST INCIDENCE (DAYS) |      694             648             341           |      578             728             729 (T)       |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.151         P=0.139         P=0.277        |     P=0.420N        P=0.283N        P=0.550N       |
|INCIDENTAL TUMOR       |     P=0.314         P=0.123         P=0.482        |     P=0.382N        P=0.324N        P=0.554N       |
|LOGISTIC REGRESSION    |     P=0.216         P=0.126         P=0.578        |     P=0.362N        P=0.300N        P=0.474N       |
|COCHRAN-ARMITAGE       |     P=0.546N                                       |     P=0.217N                                       |
|FISHER EXACT           |                     P=0.107         P=0.644N       |                     P=0.372N        P=0.281N       |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Polyp Stromal                                                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |                                                    |    12/60 (20%)     20/60 (33%)     11/59 (19%)     |
|ADJUSTED (b)           |                                                    |     29.9%           42.8%           36.9%          |
|TERMINAL (d)           |                                                    |    10/37 (27%)     17/43 (40%)      5/21 (24%)     |
|FIRST INCIDENCE (DAYS) |                                                    |      578             540             488           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                                                    |     P=0.138         P=0.164         P=0.207        |
|INCIDENTAL TUMOR       |                                                    |     P=0.301         P=0.106         P=0.423        |
|LOGISTIC REGRESSION    |                                                    |     P=0.343         P=0.119         P=0.423        |
|COCHRAN-ARMITAGE       |                                                    |     P=0.478N                                       |
|FISHER EXACT           |                                                    |                     P=0.074         P=0.518N       |
|=================================================================================================================================|
         DATE: 09/04/94                     EXPERIMENT: 05026 TEST: 01                                                 PAGE  19
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- SODIUM AZIDE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      0 G/KG          5 MG/KG         10 MG/KG      |      0 G/KG          5 MG/KG         10MG/KG       |
|                       |      VEHICLEM        LOW MALE        HIGHMALE      |      VEHICLEF        LOW FEMA        HIGH FEM      |
|=================================================================================================================================|
|                                                                                                                                 |
|Uterus                                                                                                                           |
|     Sarcoma Stromal or Polyp Stromal                                                                                            |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |                                                    |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |                                                    |    12/60 (20%)     20/60 (33%)     12/59 (20%)     |
|ADJUSTED (b)           |                                                    |     29.9%           42.8%           40.9%          |
|TERMINAL (d)           |                                                    |    10/37 (27%)     17/43 (40%)      6/21 (29%)     |
|FIRST INCIDENCE (DAYS) |                                                    |      578             540             488           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |                                                    |     P=0.088         P=0.164         P=0.135        |
|INCIDENTAL TUMOR       |                                                    |     P=0.217         P=0.106         P=0.310        |
|LOGISTIC REGRESSION    |                                                    |     P=0.256         P=0.119         P=0.316        |
|COCHRAN-ARMITAGE       |                                                    |     P=0.522                                        |
|FISHER EXACT           |                                                    |                     P=0.074         P=0.572        |
|=================================================================================================================================|
|                                                                                                                                 |
|Zymbal's Gland                                                                                                                   |
|     Carcinoma                                                                                                                   |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     3/60 (5%)       0/60 (0%)       0/60 (0%)      |     0/60 (0%)       0/60 (0%)       0/59 (0%)      |
|ADJUSTED (b)           |      7.6%            0.0%            0.0%          |      0.0%            0.0%            0.0%          |
|TERMINAL (d)           |     0/24 (0%)       0/27 (0%)       0/9 (0%)       |     0/37 (0%)       0/43 (0%)       0/21 (0%)      |
|FIRST INCIDENCE (DAYS) |      627             ---             ---           |      ---             ---             ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.060N        P=0.110N        P=0.240N       |       (e)             (e)             (e)          |
|INCIDENTAL TUMOR       |     P=0.044N*       P=0.170N        P=0.124N       |       (e)             (e)             (e)          |
|LOGISTIC REGRESSION    |     P=0.038N*       P=0.121N        P=0.148N       |       (e)             (e)             (e)          |
|COCHRAN-ARMITAGE       |     P=0.037N*                                      |       (e)                                          |
|FISHER EXACT           |                     P=0.122N        P=0.122N       |                       (e)             (e)          |
|=================================================================================================================================|
         DATE: 09/04/94                     EXPERIMENT: 05026 TEST: 01                                                 PAGE  20
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- SODIUM AZIDE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      0 G/KG          5 MG/KG         10 MG/KG      |      0 G/KG          5 MG/KG         10MG/KG       |
|                       |      VEHICLEM        LOW MALE        HIGHMALE      |      VEHICLEF        LOW FEMA        HIGH FEM      |
|=================================================================================================================================|
|                                                                                                                                 |
|Zymbal's Gland                                                                                                                   |
|     Carcinoma or Adenoma                                                                                                        |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     3/60 (5%)       1/60 (2%)       0/60 (0%)      |     0/60 (0%)       0/60 (0%)       0/59 (0%)      |
|ADJUSTED (b)           |      7.6%            3.7%            0.0%          |      0.0%            0.0%            0.0%          |
|TERMINAL (d)           |     0/24 (0%)       1/27 (4%)       0/9 (0%)       |     0/37 (0%)       0/43 (0%)       0/21 (0%)      |
|FIRST INCIDENCE (DAYS) |      627             729 (T)         ---           |      ---             ---             ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.115N        P=0.276N        P=0.240N       |       (e)             (e)             (e)          |
|INCIDENTAL TUMOR       |     P=0.084N        P=0.367N        P=0.124N       |       (e)             (e)             (e)          |
|LOGISTIC REGRESSION    |     P=0.077N        P=0.304N        P=0.148N       |       (e)             (e)             (e)          |
|COCHRAN-ARMITAGE       |     P=0.061N                                       |       (e)                                          |
|FISHER EXACT           |                     P=0.309N        P=0.122N       |                       (e)             (e)          |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Leukemia: Lymphocytic, Monocytic, Mononuclear,                                                                              |
|     or Undifferentiated                                                                                                         |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |    33/60 (55%)     28/60 (47%)     14/60 (23%)     |    16/60 (27%)     18/60 (30%)     11/59 (19%)     |
|ADJUSTED (b)           |     69.0%           60.3%           57.7%          |     36.1%           35.0%           31.5%          |
|TERMINAL (d)           |    10/24 (42%)     10/27 (37%)      2/9 (22%)      |    10/37 (27%)     11/43 (26%)      3/21 (14%)     |
|FIRST INCIDENCE (DAYS) |      520             226             474           |      457             540             449           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.306N        P=0.188N        P=0.433N       |     P=0.454         P=0.531N        P=0.498        |
|INCIDENTAL TUMOR       |     P<0.001N**      P=0.261N        P=0.001N**     |     P=0.230N        P=0.491         P=0.248N       |
|LOGISTIC REGRESSION    |     P=0.003N**      P=0.229N        P=0.009N**     |     P=0.300N        P=0.466         P=0.339N       |
|COCHRAN-ARMITAGE       |     P<0.001N**                                     |     P=0.185N                                       |
|FISHER EXACT           |                     P=0.233N        P<0.001N**     |                     P=0.420         P=0.205N       |
|=================================================================================================================================|
         DATE: 09/04/94                     EXPERIMENT: 05026 TEST: 01                                                 PAGE  21
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- SODIUM AZIDE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      0 G/KG          5 MG/KG         10 MG/KG      |      0 G/KG          5 MG/KG         10MG/KG       |
|                       |      VEHICLEM        LOW MALE        HIGHMALE      |      VEHICLEF        LOW FEMA        HIGH FEM      |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Mesothelioma Benign, Malignant, NOS                                                                                         |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     1/60 (2%)       2/60 (3%)       2/60 (3%)      |     0/60 (0%)       0/60 (0%)       0/59 (0%)      |
|ADJUSTED (b)           |      2.0%            4.7%           13.0%          |      0.0%            0.0%            0.0%          |
|TERMINAL (d)           |     0/24 (0%)       0/27 (0%)       1/9 (11%)      |     0/37 (0%)       0/43 (0%)       0/21 (0%)      |
|FIRST INCIDENCE (DAYS) |      590             632             466           |      ---             ---             ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.216         P=0.519         P=0.329        |       (e)             (e)             (e)          |
|INCIDENTAL TUMOR       |     P=0.415         P=0.408         P=0.511        |       (e)             (e)             (e)          |
|LOGISTIC REGRESSION    |     P=0.406         P=0.499         P=0.536        |       (e)             (e)             (e)          |
|COCHRAN-ARMITAGE       |     P=0.391                                        |       (e)                                          |
|FISHER EXACT           |                     P=0.500         P=0.500        |                       (e)             (e)          |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Osteosarcoma                                                                                                                |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     0/60 (0%)       0/60 (0%)       2/60 (3%)      |     0/60 (0%)       0/60 (0%)       0/59 (0%)      |
|ADJUSTED (b)           |      0.0%            0.0%           13.6%          |      0.0%            0.0%            0.0%          |
|TERMINAL (d)           |     0/24 (0%)       0/27 (0%)       1/9 (11%)      |     0/37 (0%)       0/43 (0%)       0/21 (0%)      |
|FIRST INCIDENCE (DAYS) |      ---             ---             579           |      ---             ---             ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.039 *         (e)           P=0.112        |       (e)             (e)             (e)          |
|INCIDENTAL TUMOR       |     P=0.054           (e)           P=0.132        |       (e)             (e)             (e)          |
|LOGISTIC REGRESSION    |     P=0.074           (e)           P=0.181        |       (e)             (e)             (e)          |
|COCHRAN-ARMITAGE       |     P=0.096                                        |       (e)                                          |
|FISHER EXACT           |                       (e)           P=0.248        |                       (e)             (e)          |
|=================================================================================================================================|
         DATE: 09/04/94                     EXPERIMENT: 05026 TEST: 01                                                 PAGE  22
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- SODIUM AZIDE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      0 G/KG          5 MG/KG         10 MG/KG      |      0 G/KG          5 MG/KG         10MG/KG       |
|                       |      VEHICLEM        LOW MALE        HIGHMALE      |      VEHICLEF        LOW FEMA        HIGH FEM      |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Osteosarcoma or Osteoma                                                                                                     |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |     0/60 (0%)       0/60 (0%)       2/60 (3%)      |     0/60 (0%)       0/60 (0%)       0/59 (0%)      |
|ADJUSTED (b)           |      0.0%            0.0%           13.6%          |      0.0%            0.0%            0.0%          |
|TERMINAL (d)           |     0/24 (0%)       0/27 (0%)       1/9 (11%)      |     0/37 (0%)       0/43 (0%)       0/21 (0%)      |
|FIRST INCIDENCE (DAYS) |      ---             ---             579           |      ---             ---             ---           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.039 *         (e)           P=0.112        |       (e)             (e)             (e)          |
|INCIDENTAL TUMOR       |     P=0.054           (e)           P=0.132        |       (e)             (e)             (e)          |
|LOGISTIC REGRESSION    |     P=0.074           (e)           P=0.181        |       (e)             (e)             (e)          |
|COCHRAN-ARMITAGE       |     P=0.096                                        |       (e)                                          |
|FISHER EXACT           |                       (e)           P=0.248        |                       (e)             (e)          |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Benign Tumors                                                                                                               |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |    58/60 (97%)     57/60 (95%)     49/60 (82%)     |    47/60 (78%)     44/60 (73%)     34/59 (58%)     |
|ADJUSTED (b)           |    100.0%          100.0%          100.0%          |     90.3%           79.7%           88.4%          |
|TERMINAL (d)           |    24/24 (100%)    27/27 (100%)     9/9 (100%)     |    32/37 (86%)     32/43 (74%)     17/21 (81%)     |
|FIRST INCIDENCE (DAYS) |      300             437             341           |      429             453             449           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.002 **      P=0.272N        P=0.001 **     |     P=0.247         P=0.083N        P=0.201        |
|INCIDENTAL TUMOR       |     P=0.240N        P=0.516N        P=0.286N       |     P=0.096N        P=0.153N        P=0.132N       |
|LOGISTIC REGRESSION    |     P=0.237N        P=0.614N        P=0.304N       |     P=0.154N        P=0.175N        P=0.220N       |
|COCHRAN-ARMITAGE       |     P=0.003N**                                     |     P=0.009N**                                     |
|FISHER EXACT           |                     P=0.500N        P=0.008N**     |                     P=0.335N        P=0.013N*      |
|=================================================================================================================================|
         DATE: 09/04/94                     EXPERIMENT: 05026 TEST: 01                                                 PAGE  23
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- SODIUM AZIDE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
|=================================================================================================================================|
|                       |                                                    |                                                    |
|                       |                       MALES                        |                      FEMALES                       |
|                       |                                                    |                                                    |
|DOSE                   |      0 G/KG          5 MG/KG         10 MG/KG      |      0 G/KG          5 MG/KG         10MG/KG       |
|                       |      VEHICLEM        LOW MALE        HIGHMALE      |      VEHICLEF        LOW FEMA        HIGH FEM      |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant Tumors                                                                                                            |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |    40/60 (67%)     33/60 (55%)     23/60 (38%)     |    25/60 (42%)     27/60 (45%)     16/59 (27%)     |
|ADJUSTED (b)           |     77.6%           68.7%           80.7%          |     49.9%           49.4%           43.8%          |
|TERMINAL (d)           |    13/24 (54%)     13/27 (48%)      5/9 (56%)      |    13/37 (35%)     16/43 (37%)      4/21 (19%)     |
|FIRST INCIDENCE (DAYS) |      520             226             466           |      352             453             449           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.403         P=0.125N        P=0.297        |     P=0.532N        P=0.448N        P=0.552N       |
|INCIDENTAL TUMOR       |     P=0.005N**      P=0.159N        P=0.014N*      |     P=0.059N        P=0.396         P=0.070N       |
|LOGISTIC REGRESSION    |     P=0.014N*       P=0.128N        P=0.020N*      |     P=0.092N        P=0.379         P=0.084N       |
|COCHRAN-ARMITAGE       |     P=0.001N**                                     |     P=0.063N                                       |
|FISHER EXACT           |                     P=0.131N        P=0.002N**     |                     P=0.427         P=0.070N       |
|=================================================================================================================================|
|                                                                                                                                 |
|All Organs                                                                                                                       |
|     Malignant and Benign Tumors                                                                                                 |
|                                                                                                                                 |
|---------------------------------------------------------------------------------------------------------------------------------|
|TUMOR RATES            |       #               #               #            |       #               #               #            |
|-----------            |                                                    |                                                    |
|OVERALL (a)            |    59/60 (98%)     58/60 (97%)     50/60 (83%)     |    53/60 (88%)     54/60 (90%)     39/59 (66%)     |
|ADJUSTED (b)           |    100.0%          100.0%          100.0%          |     93.0%           90.0%           90.3%          |
|TERMINAL (d)           |    24/24 (100%)    27/27 (100%)     9/9 (100%)     |    33/37 (89%)     37/43 (86%)     17/21 (81%)     |
|FIRST INCIDENCE (DAYS) |      300             226             341           |      352             453             449           |
|-----------------------|                                                    |                                                    |
|STATISTICAL TESTS (f)  |                                                    |                                                    |
|-----------------------|                                                    |                                                    |
|LIFE TABLE             |     P=0.002 **      P=0.274N        P=0.001 **     |     P=0.189         P=0.192N        P=0.183        |
|INCIDENTAL TUMOR       |     P=0.126N        P=0.566N        P=0.219N       |     P=0.017N*       P=0.577N        P=0.034N*      |
|LOGISTIC REGRESSION    |     P=0.040N*       P=0.570N        P=0.116N       |     P=0.041N*       P=0.561N        P=0.118N       |
|COCHRAN-ARMITAGE       |     P=0.001N**                                     |     P=0.001N**                                     |
|FISHER EXACT           |                     P=0.500N        P=0.004N**     |                     P=0.500         P=0.003N**     |
|=================================================================================================================================|
         DATE: 09/04/94                     EXPERIMENT: 05026 TEST: 01                                                 PAGE  24
                              STATISTICAL ANALYSIS OF PRIMARY TUMORS IN RATS(FISCHER344) -- SODIUM AZIDE
                                                 TERMINAL SACRIFICE AT 105 WEEKS
 (a)  Number of tumor-bearing animals / number of animals examined at site.
 (b)  Kaplan-Meier estimated lifetime tumor incidence after adjustment for 
      intercurrent mortality.
 (d)  Observed incidence at terminal kill.
 (f)  Beneath the control incidence are the P-values associated with the trend 
      test.  Beneath the dosed group incidence are the P-values corresponding to 
      pairwise comparisons between the controls and that dosed group.  The life
      table analysis regards tumors in animals dying  prior to terminal kill as
      being (directly or indirectly) the cause of death.  The incidental tumor 
      test regards these lesions as non-fatal.  Logistic regression is an alternative
      method for analyzing the incidence of non-fatal tumors.  The Cochran-Armitage
      and Fisher's exact tests compare directly the overall incidence rates.  
      For all tests, a negative trend is indicated by "N".
 (e)  Value of Statistic cannot be computed. 
 (I)  Interim sacrifice
 (T)  Terminal sacrifice
  #   Tumor rates based on number of animals necropsied.
  *   To the right of any statistical result, indicates significance at (P<=0.05).
  **  To the right of any statistical result, indicates significance at (P<=0.01).
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