National Toxicology Program

National Toxicology Program
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TR 389 Rat Pathology Tables

NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11 
LAB: Microbiological Assoc.                                    DATE: 09/04/94   
EXP: 05026                       SODIUM AZIDE                  TIME: 07:56:14   
TEST: 01              CAGES FROM 0000 TO LAST CAGE             PAGE:   1        
TEST TYPE: CHRONIC          ROUTE: GAVAGE                      NTP C#: 06462    
CONT: N01C09565001                                             CAS: 26628228    
PATHOLOGIST: G. PARKER                                                          
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REASONS FOR REMOVAL:                                                            
                                                                                
ALL                                                                             
                                                                                
                                                                                
REMOVAL DATE RANGE:                                                             


ALL                                                                             
                                                                                
TREATMENT GROUPS:                                                               
                                                                                
INCLUDE ALL                                                                     

NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11
LAB: Microbiological Assoc.                                    DATE: 09/04/94  
EXP: 05026                       SODIUM AZIDE                  TIME: 07:56:14  
TEST: 01              CAGES FROM 0000 TO LAST CAGE                             
TEST TYPE: CHRONIC          ROUTE: GAVAGE                      NTP C#: 06462   
CONT: N01C09565001                                             CAS: 26628228   
PATHOLOGIST: G. PARKER                                                         

                                   SODIUM AZIDE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE RATS
                       FIRST TERMINAL SACRIFICE AT 729 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                          DOSE = 0 G/KG  VEHICLEM                               |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 35     CENSORED DEATHS 1    TERMINAL 24        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      151   300   495   495   520   549   555   561   568   572                 |
 |      589   590   603   604   627   633   640   652   654   658                 |
 |      674   678   681   681   690   693   694   694   695   697                 |
 |      703   703   711   719   727                                               |
 |  CENSORED DEATHS                                                               |
 |      626                                                                       |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 5 MG/KG LOW                              |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 31     CENSORED DEATHS 2    TERMINAL 27        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      226   403   437   502   516   529   547   576   579   589                 |
 |      591   632   639   640   641   648   659   660   673   681                 |
 |      683   690   690   693   698   702   704   708   712   717                 |
 |      723                                                                       |
 |  CENSORED DEATHS                                                               |
 |      227   716                                                                 |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = 10 MG/KGHIGH                                   |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 42     CENSORED DEATHS 9    TERMINAL 9         |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      220   348   414   415   415   432   432   466   474   512                 |
 |      543   557   557   563   563   569   579   591   596   607                 |
 |      617   637   640   645   645   648   649   650   654   659                 |
 |      662   662   662   667   667   669   670   677   677   677                 |
 |      681   719                                                                 |
 |  CENSORED DEATHS                                                               |
 |      233   235   332   339   341   341   341   526   701                       |
 |                                                                                |
 ==================================================================================

                                   SODIUM AZIDE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE RATS
                       FIRST TERMINAL SACRIFICE AT 729 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   729 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |0          |   100.0  98.3  98.3  96.7  96.7  96.7  91.7  76.7  66.4  40.9      |
 |G/KG  VEHIC|EM                                                                  |
 |           |                                                                    |
 |5 MG/KG LOW|   100.0 100.0  98.3  98.3  96.6  94.9  89.9  81.4  69.5  47.4      |
 |           |                                                                    |
 |           |                                                                    |
 |10         |   100.0 100.0  98.3  96.4  90.8  83.2  79.4  63.9  36.8  19.2      |
 |MG/KGHIGH  |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                    DOSE                        |
 |                                                                                |
 |                                0                5 MG/KG LOW      10            |
 |                                G/KG  VEHICLEM                    MG/KGHIGH     |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       40.9%            47.4%            19.2%         |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=0.003          P=0.555N         P=0.002       |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       613.0            615.7            580.6         |
 |NATURAL DEATHS (C)      |       (20.0)           (19.8)           (16.9)        |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       659.6            661.9            572.3         |
 |(STANDARD ERROR)        |       (13.7)           (14.5)           (18.7)        |
 |                        |                                                       |
 ==================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                                   SODIUM AZIDE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE RATS
                       FIRST TERMINAL SACRIFICE AT 729 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                          DOSE = 0 G/KG  VEHICLEF                               |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 23     CENSORED DEATHS 0    TERMINAL 37        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      306   316   352   429   457   488   496   569   575   578                 |
 |      594   596   603   643   649   671   680   684   693   699                 |
 |      705   714   719                                                           |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = 5 MG/KG LOW    A                               |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 17     CENSORED DEATHS 0    TERMINAL 43        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      453   502   540   549   603   604   628   648   670   684                 |
 |      695   705   719   721   722   728   728                                   |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = 10MG/KG HIGH                                   |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 59     UNCENSORED DEATHS 33     CENSORED DEATHS 5    TERMINAL 21        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      106   141   152   201   206   395   449   468   488   495                 |
 |      502   502   516   549   569   610   612   642   646   646                 |
 |      646   647   649   650   653   654   654   659   660   667                 |
 |      688   691   705                                                           |
 |  CENSORED DEATHS                                                               |
 |      103   104   108   108   109                                               |
 |                                                                                |
 ==================================================================================

                                   SODIUM AZIDE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE RATS
                       FIRST TERMINAL SACRIFICE AT 729 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   729 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |0          |   100.0 100.0 100.0  95.0  95.0  91.7  88.3  78.3  75.0  61.7      |
 |G/KG  VEHIC|EF                                                                  |
 |           |                                                                    |
 |5          |   100.0 100.0 100.0 100.0 100.0  98.3  95.0  90.0  86.7  71.7      |
 |MG/KG LOW  | A                                                                  |
 |           |                                                                    |
 |10MG/KG    |   100.0  94.5  90.8  90.8  89.0  85.3  76.0  72.3  46.3  38.9      |
 |HIGH       |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                    DOSE                        |
 |                                                                                |
 |                                0                5                10MG/KG       |
 |                                G/KG  VEHICLEF   MG/KG LOW    A   HIGH          |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       61.7%            71.7%            38.9%         |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=0.010          P=0.223N         P=0.015       |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       574.6            641.1            530.8         |
 |NATURAL DEATHS (C)      |       (27.0)           (21.0)           (30.9)        |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       669.8            704.1            565.4         |
 |(STANDARD ERROR)        |       (14.1)           ( 7.8)           (27.9)        |
 |                        |                                                       |
 ==================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                                                            SODIUM AZIDE
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        0 G/KG  VEHICLEM = 1
                                                        5 MG/KG LOW      = 2
                                                        10 MG/KGHIGH     = 3

------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  100 + 1                       1          32
      |                         1          32          1       3        2 3  2        1
      |                                                                      2         2
      |                                                                               12 2 12  1
   90 +                                                                   3 3               2  11
      |                                                                     3     3            21112
      |                                                                           33               2  2
      |                                                                            3     3    3   1   1     2
P  80 +                                                                                       3 3     1 1   22
E     |                                                                                                 1  1
R     |                                                                                         33         1122
C     |                                                                                          33         1121 2
E  70 +                                                                                           33             2 2
N     |                                                                                            3  3        1   12
T     |                                                                                               333           22
      |                                                                                                 3 3        11
S  60 +                                                                                                   3 3       112
U     |                                                                                                     33        22
R     |                                                                                                      33      1122
V     |
I  50 +                                                                                                               11222
V     |                                                                                                       33          2 2
A     |                                                                                                        3 3     111
L     |                                                                                                                  11
   40 +                                                                                                                   1 1
      |                                                                                                          33
      |
      |
   30 +                                                                                                           33
      |
      |
      |                                                                                                            33    3
   20 +                                                                                                                  3  3
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 18 obs hidden.

                                                            SODIUM AZIDE
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        0 G/KG  VEHICLEF = 1
                                                        5 MG/KG LOW    A = 2
                                                        10MG/KG HIGH     = 3

----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  100 + 1                 3                             1                       2
      |                   3    33                       1  1    1               2      2      2
      |                         3       3                       1           1                 22
      |                                 33                                  1    1   1         2        2
   90 +                                  3                             3        3    11                 2  2
      |                                                                         3 3   1           11       2  2   2
P     |                                                                           3  3                            2 2
E     |                                                                              333           1  11            2 22
R  80 +                                                                                                11              2 2
C     |                                                                                3 3              1    11          22
E     |                                                                                  3     3  3           1   1
N     |                                                                                           3      3        1 1     2 2
T  70 +                                                                                                             11
      |                                                                                                  3   33      111
S     |                                                                                                                11
U     |                                                                                                                 11  1
R  60 +
V     |
I     |                                                                                                       33
V     |
A  50 +                                                                                                        3 3
L     |                                                                                                          33
      |                                                                                                           3  3
      |
   40 +                                                                                                              3 3    3
      |
      |
      |
   30 +
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 18 obs hidden.

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