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TR 391 Mouse Pathology Tables

NTP Experiment-Test: 05042-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TRIS (2-CHLOROETHYL) PHOSPHATE                              Date: 04/29/97
Route: GAVAGE                                                                                                     Time: 16:56:49




       Facility:  Microbiological Associates

       Chemical CAS #:  115-96-8

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All






































                                                              Page   1

NTP Experiment-Test: 05042-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TRIS (2-CHLOROETHYL) PHOSPHATE                              Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 16:56:49  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 6| 7| 7| 7| 4| 3| 7| 7| 7| 6| 2|             
                             DAY ON TEST   | 2| 2| 2| 2| 1| 2| 2| 1| 0| 0| 2| 2| 2| 2| 1| 2| 2| 2| 6| 6| 2| 2| 2| 6| 3|             
                                           | 9| 9| 9| 9| 8| 9| 9| 6| 0| 2| 9| 9| 9| 9| 0| 9| 9| 9| 9| 0| 9| 9| 9| 9| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    CONTROL                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Periesophageal Tissue, Foreign Body  |                                                                          |             
      Periesophageal Tissue, Inflammation, |                                                                          |             
           Acute                           |                            2                             1               |             
      Wall, Inflammation, Necrotizing      |                                                                          |             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  A  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  M  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  M  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | M  M  M  M  M  M  M  M  M  A  M  M  +  M  A  M  M  +  A  M  +  M  +  M  M|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  A  +  +  +  +  A  +  +  +  A  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Eosinophilic Focus                   |                                                                          |             
      Hematopoietic Cell Proliferation     |                   1                                                      |             
      Inflammation, Chronic                |                1                                                         |             
      Vacuolization Cytoplasmic            |                                  1                                       |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                  +        +  +                           |             
      Infiltration Cellular, Mast Cell     |                                                                          |             
      Fat, Necrosis                        |                                              2                           |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |                                                                1         |             
      Acinus, Basophilic Focus             |                                                                          |             
      Acinus, Necrosis, Coagulative        |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                2              1              1                       1   |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Squamous                |                                  1                                       |             
      Infiltration Cellular, Mast Cell     |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Mast Cell     |                                                                          |             
      Mucosa, Dilatation                   |                                              2                           |             
      Mucosa, Hyperplasia                  |                                                    1                     |             
                                            __________________________________________________________________________|             
   Tooth                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                                                 2  1                     |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05042-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TRIS (2-CHLOROETHYL) PHOSPHATE                              Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 16:56:49  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 6| 7| 7| 7| 4| 3| 7| 7| 7| 6| 2|             
                             DAY ON TEST   | 2| 2| 2| 2| 1| 2| 2| 1| 0| 0| 2| 2| 2| 2| 1| 2| 2| 2| 6| 6| 2| 2| 2| 6| 3|             
                                           | 9| 9| 9| 9| 8| 9| 9| 6| 0| 2| 9| 9| 9| 9| 0| 9| 9| 9| 9| 0| 9| 9| 9| 9| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    CONTROL                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Epicardium, Inflammation, Acute      |                            3                             3               |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Degeneration, Ballooning             |                                                             2            |             
      Hypertrophy, Focal                   |                1                                                         |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                     2        1                           |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  M  +  +  +  M  +  +  +  +  M  +  +  +  +  +  M  M  M  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Pars Distalis, Angiectasis           |                                                    1                     |             
      Pars Distalis, Hyperplasia           |                                     3                       3        2   |             
      Pars Distalis, Hypertrophy, Focal    |       1                                                                  |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |                                              2  1                        |             
      Follicular Cell, Hyperplasia         |                                  1  1        4                 1     2   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | M  M  +  +  M  M  +  +  +  +  +  M  M  +  M  +  +  +  +  +  +  +  M  +  +|             
      Cyst                                 |       3  3        2           3        4           2                 4   |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Endometrium, Hyperplasia, Cystic     | 3  3  2  3  2  3  2  2  2  1  2  3  3  3  1  2  3  2  2  1  3  3  3  3  1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Myelofibrosis                        | 1     2  1                          1                             1      |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Iliac, Hemorrhage                    |                                                                3         |             
      Iliac, Hyperplasia, Plasma Cell      |                3                                                         |             
      Inguinal, Infiltration Cellular,     |                                                                          |             
           Mast Cell                       |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Plasma Cell             |                2                                                         |             
      Infiltration Cellular, Mast Cell     |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Ectasia                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05042-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TRIS (2-CHLOROETHYL) PHOSPHATE                              Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 16:56:49  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 6| 7| 7| 7| 4| 3| 7| 7| 7| 6| 2|             
                             DAY ON TEST   | 2| 2| 2| 2| 1| 2| 2| 1| 0| 0| 2| 2| 2| 2| 1| 2| 2| 2| 6| 6| 2| 2| 2| 6| 3|             
                                           | 9| 9| 9| 9| 8| 9| 9| 6| 0| 2| 9| 9| 9| 9| 0| 9| 9| 9| 9| 0| 9| 9| 9| 9| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    CONTROL                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                         1                                                |             
      Hematopoietic Cell Proliferation     |                                                          2               |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Hyperplasia, Plasma Cell             |                2                                                         |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |             1                                                            |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Mediastinum, Foreign Body            |                                                                      3   |             
      Mediastinum, Inflammation, Acute     |                                                          2           3   |             
      Thymocyte, Necrosis                  |                                                          3               |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  |                                  1                                       |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                        2                                 |             
      Inflammation, Acute                  |                                                 1                        |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Granulomatous          |                                        2                                 |             
      Subcutaneous Tissue, Abscess         |                                                          4               |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Head, Inflammation, Acute            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                      3                                                   |             
      Meninges, Inflammation, Chronic      |                                                                          |             
      Thalamus, Inflammation               |                                                                          |             
      Thalamus, Mineralization             | 1     1        1  1     1     1        1  1  1  1     1        2  1      |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Foreign Body                         |                                                                          |             
      Hemorrhage                           |                                                                         2|             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |                                                                   1      |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05042-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TRIS (2-CHLOROETHYL) PHOSPHATE                              Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 16:56:49  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 7| 6| 7| 7| 7| 4| 3| 7| 7| 7| 6| 2|             
                             DAY ON TEST   | 2| 2| 2| 2| 1| 2| 2| 1| 0| 0| 2| 2| 2| 2| 1| 2| 2| 2| 6| 6| 2| 2| 2| 6| 3|             
                                           | 9| 9| 9| 9| 8| 9| 9| 6| 0| 2| 9| 9| 9| 9| 0| 9| 9| 9| 9| 0| 9| 9| 9| 9| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    CONTROL                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
           Histiocyte                      |                                                                          |             
      Mediastinum, Foreign Body            |             2              1                                             |             
      Mediastinum, Inflammation, Acute     |                            3                                             |             
      Pleura, Inflammation, Acute          |                            4                             2               |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Mast Cell     |                                                                          |             
      Inflammation, Acute                  |       1                                                                  |             
      Respiratory Epithelium, Inflammation,|                                                                          |             
           Acute                           |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Peritracheal Tissue, Foreign Body    |                                                          2               |             
      Peritracheal Tissue, Inflammation,   |                                                                          |             
           Acute                           |                                                          2               |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                            +                          +  +              +|             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                               2                                          |             
      Inflammation, Chronic                | 4                                                                        |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Metaplasia, Osseous                  |                   1                                                      |             
      Nephropathy                          |                2  2                 1  1     1                           |             
      Glomerulus, Amyloid Deposition       |                         3                                                |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05042-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TRIS (2-CHLOROETHYL) PHOSPHATE                              Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 16:56:49  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 3| 7| 7| 7| 7| 3| 7| 7| 7| 5| 3| 7| 7| 7| 6| 5| 7| 7| 6| 5| 3|             
                             DAY ON TEST   | 2| 2| 2| 6| 0| 2| 2| 2| 2| 0| 2| 2| 2| 4| 6| 2| 2| 2| 3| 3| 2| 2| 3| 4| 9|             
                                           | 9| 9| 9| 9| 2| 9| 9| 9| 9| 4| 9| 9| 9| 0| 5| 9| 9| 9| 2| 7| 9| 9| 9| 4| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    CONTROL                                | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Periesophageal Tissue, Foreign Body  |                            1                                             |             
      Periesophageal Tissue, Inflammation, |                                                                          |             
           Acute                           |                            2                                             |             
      Wall, Inflammation, Necrotizing      |             3                                                            |             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  A  +  +  +  +  M  +  +  +  A  +  +  +  +  M  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  A  +  +  +  +  A  +  +  +  A  +  +  +  +  +  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  M  M  M  A  M  M  +  M  A  M  M  M  A  M  M  +  M  M  A  +  M  M  M  M|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  A  +  +  +  +  A  +  +  +  A  +  +  +  +  +  A  +  +  +  +  +|             
      Hyperplasia, Lymphoid                | 2     2                                                                  |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  A  +  +  +  +  A  +  +  +  A  +  +  +  +  +  A  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |       2                                                                  |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Eosinophilic Focus                   |                3                                                         |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Vacuolization Cytoplasmic            |                      1                 2                                 |             
                                            __________________________________________________________________________|             
   Mesentery                               |    +                                            +                 +     +|             
      Infiltration Cellular, Mast Cell     |    1                                                                     |             
      Fat, Necrosis                        |    2                                            3                        |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |                         2                       4                    2   |             
      Acinus, Basophilic Focus             |                      3                                                   |             
      Acinus, Necrosis, Coagulative        |                                                                2         |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                   2                       1  1  1                        |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Squamous                |    3                                         1           1               |             
      Infiltration Cellular, Mast Cell     |    4                                                                     |             
      Inflammation, Acute                  |                                     1                                    |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Mast Cell     |    1                                                                     |             
      Mucosa, Dilatation                   |                                                                          |             
      Mucosa, Hyperplasia                  |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   6                                                               
NTP Experiment-Test: 05042-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TRIS (2-CHLOROETHYL) PHOSPHATE                              Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 16:56:49  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 3| 7| 7| 7| 7| 3| 7| 7| 7| 5| 3| 7| 7| 7| 6| 5| 7| 7| 6| 5| 3|             
                             DAY ON TEST   | 2| 2| 2| 6| 0| 2| 2| 2| 2| 0| 2| 2| 2| 4| 6| 2| 2| 2| 3| 3| 2| 2| 3| 4| 9|             
                                           | 9| 9| 9| 9| 2| 9| 9| 9| 9| 4| 9| 9| 9| 0| 5| 9| 9| 9| 2| 7| 9| 9| 9| 4| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    CONTROL                                | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Epicardium, Inflammation, Acute      |             3                             2                              |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Atrophy                              |    2                                                                     |             
      Degeneration, Ballooning             |                                                                          |             
      Hypertrophy, Focal                   |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  M  +  M  +  +  +  M  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                                                       4     1  2         |             
      Pars Distalis, Hyperplasia           |                               3  1                             2         |             
      Pars Distalis, Hypertrophy, Focal    |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                               1                                          |             
      Inflammation, Chronic                |                                                                          |             
      Follicular Cell, Hyperplasia         |             1                                                            |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  M  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +|             
      Cyst                                 | 2        3           2  2     4                       3                 2|             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                 2                        |             
      Endometrium, Hyperplasia, Cystic     | 3  1  1  3  2  2  3  2  3     2  3  3  1  1  3  3  3  1  2  1  2  2  2  2|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Myelofibrosis                        | 1              1     1           1              1  1           1         |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Iliac, Hemorrhage                    |                                                                          |             
      Iliac, Hyperplasia, Plasma Cell      |                                                                          |             
      Inguinal, Infiltration Cellular,     |                                                                          |             
           Mast Cell                       |    3                                                                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Hyperplasia, Plasma Cell             |                                                                          |             
      Infiltration Cellular, Mast Cell     |    2                                                                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  M  +|             
      Ectasia                              | 3                                                                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   7                                                               
NTP Experiment-Test: 05042-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TRIS (2-CHLOROETHYL) PHOSPHATE                              Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 16:56:49  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 3| 7| 7| 7| 7| 3| 7| 7| 7| 5| 3| 7| 7| 7| 6| 5| 7| 7| 6| 5| 3|             
                             DAY ON TEST   | 2| 2| 2| 6| 0| 2| 2| 2| 2| 0| 2| 2| 2| 4| 6| 2| 2| 2| 3| 3| 2| 2| 3| 4| 9|             
                                           | 9| 9| 9| 9| 2| 9| 9| 9| 9| 4| 9| 9| 9| 0| 5| 9| 9| 9| 2| 7| 9| 9| 9| 4| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    CONTROL                                | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hyperplasia, Lymphoid                |       2                                                                  |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                         3|             
      Hyperplasia, Lymphoid                |                      1        2                                          |             
      Hyperplasia, Plasma Cell             |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hyperplasia, Lymphoid                |                                                    1                     |             
      Mediastinum, Foreign Body            |                                                                          |             
      Mediastinum, Inflammation, Acute     |             2                                                            |             
      Thymocyte, Necrosis                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  |    2                                                  2                  |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |                                                 2                        |             
      Inflammation, Granulomatous          |                                                                          |             
      Subcutaneous Tissue, Abscess         |             3                                                            |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |          3                                                               |             
      Head, Inflammation, Acute            |                                  1                                       |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Meninges, Inflammation, Chronic      |                                              1                           |             
      Thalamus, Inflammation               |                      1                                                   |             
      Thalamus, Mineralization             | 1     1        1                                1     1  1     1     2   |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                            2           3                                 |             
      Foreign Body                         |             3                                                            |             
      Hemorrhage                           |                                                                      2   |             
      Inflammation, Acute                  |             1                                                            |             
      Inflammation, Chronic                |    1                                                                     |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   8                                                               
NTP Experiment-Test: 05042-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TRIS (2-CHLOROETHYL) PHOSPHATE                              Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 16:56:49  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 3| 7| 7| 7| 7| 3| 7| 7| 7| 5| 3| 7| 7| 7| 6| 5| 7| 7| 6| 5| 3|             
                             DAY ON TEST   | 2| 2| 2| 6| 0| 2| 2| 2| 2| 0| 2| 2| 2| 4| 6| 2| 2| 2| 3| 3| 2| 2| 3| 4| 9|             
                                           | 9| 9| 9| 9| 2| 9| 9| 9| 9| 4| 9| 9| 9| 0| 5| 9| 9| 9| 2| 7| 9| 9| 9| 4| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    CONTROL                                | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
           Histiocyte                      |                         1                                                |             
      Mediastinum, Foreign Body            |                            1           2                                 |             
      Mediastinum, Inflammation, Acute     |                            3                                             |             
      Pleura, Inflammation, Acute          |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Mast Cell     |    2                                                                     |             
      Inflammation, Acute                  |                                                                          |             
      Respiratory Epithelium, Inflammation,|                                                                          |             
           Acute                           |                                     1                                    |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Peritracheal Tissue, Foreign Body    |                                           2                              |             
      Peritracheal Tissue, Inflammation,   |                                                                          |             
           Acute                           |             3                                                            |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                           +                             +|             
                                            __________________________________________________________________________|             
   Eye                                     |             +                             +              +              +|             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Metaplasia, Osseous                  |                                                                          |             
      Nephropathy                          |    2                          1     1                                    |             
      Glomerulus, Amyloid Deposition       |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                1         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   9                                                               
NTP Experiment-Test: 05042-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TRIS (2-CHLOROETHYL) PHOSPHATE                              Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 16:56:49  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 2|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 9|                                            |            |
                                           | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    CONTROL                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |      L     |
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |                                                                          |  50        |
      Periesophageal Tissue, Foreign Body  |                                                                          |      1  1.0|
      Periesophageal Tissue, Inflammation, |                                                                          |            |
           Acute                           |                                                                          |      3  1.7|
      Wall, Inflammation, Necrotizing      |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Gallbladder                             |                                                                          |  41        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |                                                                          |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |                                                                          |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |                                                                          |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |                                                                          |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |                                                                          |  45        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |                                                                          |   8        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                                                                          |  43        |
      Hyperplasia, Lymphoid                |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                                                                          |  45        |
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Liver                                   |                                                                          |  50        |
      Eosinophilic Focus                   |                                                                          |      1  3.0|
      Hematopoietic Cell Proliferation     |                                                                          |      1  1.0|
      Inflammation, Chronic                |                                                                          |      1  1.0|
      Vacuolization Cytoplasmic            |                                                                          |      3  1.3|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   7        |
      Infiltration Cellular, Mast Cell     |                                                                          |      1  1.0|
      Fat, Necrosis                        |                                                                          |      3  2.3|
                                            __________________________________________________________________________|____________|
   Pancreas                                |                                                                          |  49        |
      Acinus, Atrophy                      |                                                                          |      4  2.3|
      Acinus, Basophilic Focus             |                                                                          |      1  3.0|
      Acinus, Necrosis, Coagulative        |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |                                                                          |  50        |
      Inflammation, Chronic                |                                                                          |      8  1.3|
                                            __________________________________________________________________________|____________|
   Stomach                                 |                                                                          |  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |                                                                          |  49        |
      Hyperplasia, Squamous                |                                                                          |      4  1.5|
      Infiltration Cellular, Mast Cell     |                                                                          |      1  4.0|
      Inflammation, Acute                  |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |                                                                          |  48        |
      Infiltration Cellular, Mast Cell     |                                                                          |      1  1.0|
      Mucosa, Dilatation                   |                                                                          |      1  2.0|
      Mucosa, Hyperplasia                  |                                                                          |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  10                                                               
NTP Experiment-Test: 05042-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TRIS (2-CHLOROETHYL) PHOSPHATE                              Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 16:56:49  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 2|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 9|                                            |            |
                                           | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    CONTROL                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |      L     |
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |  49        |
      Inflammation, Acute                  |                                                                          |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |                                                                          |  50        |
      Epicardium, Inflammation, Acute      |                                                                          |      4  2.8|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |                                                                          |  49        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |                                                                          |  49        |
      Atrophy                              |                                                                          |      1  2.0|
      Degeneration, Ballooning             |                                                                          |      1  2.0|
      Hypertrophy, Focal                   |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |                                                                          |  49        |
      Hyperplasia                          |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |                                                                          |  48        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |                                                                          |  39        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |                                                                          |  48        |
      Pars Distalis, Angiectasis           |                                                                          |      4  2.0|
      Pars Distalis, Hyperplasia           |                                                                          |      6  2.3|
      Pars Distalis, Hypertrophy, Focal    |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |                                                                          |  50        |
      Inflammation, Acute                  |                                                                          |      1  1.0|
      Inflammation, Chronic                |                                                                          |      2  1.5|
      Follicular Cell, Hyperplasia         |                                                                          |      6  1.7|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   |                                                                          |  37        |
      Cyst                                 |                                                                          |     14  2.8|
                                            __________________________________________________________________________|____________|
   Uterus                                  |                                                                          |  50        |
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Endometrium, Hyperplasia, Cystic     |                                                                          |     49  2.2|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |                                                                          |  49        |
      Myelofibrosis                        |                                                                          |     12  1.1|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  11                                                               
NTP Experiment-Test: 05042-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TRIS (2-CHLOROETHYL) PHOSPHATE                              Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 16:56:49  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 2|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 9|                                            |            |
                                           | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    CONTROL                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |      L     |
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |  49        |
      Iliac, Hemorrhage                    |                                                                          |      1  3.0|
      Iliac, Hyperplasia, Plasma Cell      |                                                                          |      1  3.0|
      Inguinal, Infiltration Cellular,     |                                                                          |            |
           Mast Cell                       |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |                                                                          |  47        |
      Hyperplasia, Plasma Cell             |                                                                          |      1  2.0|
      Infiltration Cellular, Mast Cell     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                                                                          |  45        |
      Ectasia                              |                                                                          |      1  3.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  |                                                                          |  50        |
      Atrophy                              |                                                                          |      1  1.0|
      Hematopoietic Cell Proliferation     |                                                                          |      2  2.5|
      Hyperplasia, Lymphoid                |                                                                          |      2  1.5|
      Hyperplasia, Plasma Cell             |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  |                                                                          |  45        |
      Cyst                                 |                                                                          |      1  1.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  1.0|
      Mediastinum, Foreign Body            |                                                                          |      1  3.0|
      Mediastinum, Inflammation, Acute     |                                                                          |      3  2.3|
      Thymocyte, Necrosis                  |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |                                                                          |  48        |
      Hyperplasia, Cystic                  |                                                                          |      3  1.7|
                                            __________________________________________________________________________|____________|
   Skin                                    |                                                                          |  50        |
      Foreign Body                         |                                                                          |      1  2.0|
      Inflammation, Acute                  |                                                                          |      1  1.0|
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Inflammation, Granulomatous          |                                                                          |      1  2.0|
      Subcutaneous Tissue, Abscess         |                                                                          |      2  3.5|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |                                                                          |  49        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |  49        |
      Hemorrhage                           |                                                                          |      1  3.0|
      Head, Inflammation, Acute            |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  12                                                               
NTP Experiment-Test: 05042-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TRIS (2-CHLOROETHYL) PHOSPHATE                              Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 16:56:49  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 2|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 9|                                            |            |
                                           | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    CONTROL                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |      L     |
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |                                                                          |  50        |
      Hemorrhage                           |                                                                          |      1  3.0|
      Meninges, Inflammation, Chronic      |                                                                          |      1  1.0|
      Thalamus, Inflammation               |                                                                          |      1  1.0|
      Thalamus, Mineralization             |                                                                          |     21  1.1|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |                                                                          |  50        |
      Congestion                           |                                                                          |      2  2.5|
      Foreign Body                         |                                                                          |      1  3.0|
      Hemorrhage                           |                                                                          |      2  2.0|
      Inflammation, Acute                  |                                                                          |      1  1.0|
      Inflammation, Chronic                |                                                                          |      2  1.0|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |                                                                          |      1  1.0|
      Mediastinum, Foreign Body            |                                                                          |      4  1.5|
      Mediastinum, Inflammation, Acute     |                                                                          |      2  3.0|
      Pleura, Inflammation, Acute          |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Nose                                    |                                                                          |  49        |
      Infiltration Cellular, Mast Cell     |                                                                          |      1  2.0|
      Inflammation, Acute                  |                                                                          |      1  1.0|
      Respiratory Epithelium, Inflammation,|                                                                          |            |
           Acute                           |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 |                                                                          |  50        |
      Peritracheal Tissue, Foreign Body    |                                                                          |      2  2.0|
      Peritracheal Tissue, Inflammation,   |                                                                          |            |
           Acute                           |                                                                          |      2  2.5|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   8        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |  49        |
      Hyperplasia                          |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |                                                                          |  50        |
      Metaplasia, Osseous                  |                                                                          |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  13                                                               
NTP Experiment-Test: 05042-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TRIS (2-CHLOROETHYL) PHOSPHATE                              Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 16:56:49  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 2|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 9|                                            |            |
                                           | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    CONTROL                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |      L     |
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Nephropathy                          |                                                                          |      8  1.4|
      Glomerulus, Amyloid Deposition       |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |                                                                          |  49        |
      Inflammation, Chronic                |                                                                          |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  14                                                               
NTP Experiment-Test: 05042-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TRIS (2-CHLOROETHYL) PHOSPHATE                              Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 16:56:49  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 6| 6|             
                             DAY ON TEST   | 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 2| 3| 3| 3| 3| 3| 3| 6| 2|             
                                           | 0| 0| 0| 0| 4| 0| 0| 0| 0| 0| 0| 0| 0| 0| 8| 0| 6| 0| 0| 0| 0| 0| 0| 6| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    175MG/KG                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    LOW FEM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |             +                             +     +                    +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             |             +                             +     +                    +  A|             
                                            __________________________________________________________________________|             
   Intestine Large                         |             +                             +     +                    +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |             +                             +     A                    +  A|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |             +                             +     +                    +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |             +                             +     A                    +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         |             +                             +     +                    +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |             M                             M     +                    M  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |             +                             +     M                    +  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |             +                             +     +                    +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Eosinophilic Focus                   |                                              2                           |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Inflammation, Chronic                |    2                                                                     |             
      Necrosis, Coagulative                |                                                                          |             
      Vacuolization Cytoplasmic            |          1                                                           3   |             
                                            __________________________________________________________________________|             
   Mesentery                               |                   +  +                          +              +        +|             
      Fat, Necrosis                        |                   2  2                          3              3        3|             
                                            __________________________________________________________________________|             
   Pancreas                                |             +                             +     +                    +  +|             
      Acinus, Atrophy                      |                                                                      2   |             
      Acinus, Basophilic Focus             |                                                                          |             
      Duct, Ectasia                        |                                                                      4   |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |             +                             +     +                    +  +|             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Squamous                |                                                          2               |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Tooth                                   |             +                             +     +                    +  +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |             +                             +     +                    +  +|             
      Inflammation, Chronic                |                                                 1                        |             
      Atrium, Thrombosis                   |                                                                          |             
      Epicardium, Inflammation, Acute      |             2                                                            |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |             +                             +     +                    +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |             +                             +     +                    +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |             +                             +     +                    +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |             +                             +     +                    +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |             +                             +     +                    +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |             +                          +  +     +                    +  M|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  15                                                               
NTP Experiment-Test: 05042-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TRIS (2-CHLOROETHYL) PHOSPHATE                              Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 16:56:49  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 6| 6|             
                             DAY ON TEST   | 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 2| 3| 3| 3| 3| 3| 3| 6| 2|             
                                           | 0| 0| 0| 0| 4| 0| 0| 0| 0| 0| 0| 0| 0| 0| 8| 0| 6| 0| 0| 0| 0| 0| 0| 6| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    175MG/KG                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    LOW FEM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pars Distalis, Hyperplasia           |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |             +                             +     +                    +  +|             
      Follicle, Cyst                       |                                                 2                        |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   |             +  +                          +     +        +           M  +|             
      Cyst                                 |                3                          3     3        2               |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +        +  +  +  +  +|             
      Hydrometra                           |                                                                          |             
      Endometrium, Hyperplasia, Cystic     | 2  3  3     1  3  2  2  3  2  3  2  3     1  4  1  3        3  3  2  2  2|             
      Endometrium, Inflammation, Acute     | 2                                                  1                     |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |             +                             +     +                    +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |             +                             +     +              +     +  +|             
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |             +                             +     +                    M  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |             +                             +     +              +     +  +|             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  |    +  +     +                    +  +     +     +              +     +  +|             
      Hematopoietic Cell Proliferation     |             3                                                           2|             
      Hyperplasia, Lymphoid                |    3                             1                                       |             
                                            __________________________________________________________________________|             
   Thymus                                  |             +                             M     +                    I  +|             
      Mediastinum, Inflammation, Acute     |             3                                                            |             
      Thymocyte, Necrosis                  |             3                                                            |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    +        +  +        +  +  +  +        +     +     +  +  +  +     +  +|             
      Hyperplasia, Cystic                  |                                                 2              2        2|             
      Duct, Hyperplasia                    |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                      2   |             
      Inflammation, Acute                  |                                                          4           1   |             
      Subcutaneous Tissue, Necrosis        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |             +                             +     +                    +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |             +                             +     +                    +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  16                                                               
NTP Experiment-Test: 05042-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TRIS (2-CHLOROETHYL) PHOSPHATE                              Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 16:56:49  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 7| 6| 6|             
                             DAY ON TEST   | 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 2| 3| 3| 3| 3| 3| 3| 6| 2|             
                                           | 0| 0| 0| 0| 4| 0| 0| 0| 0| 0| 0| 0| 0| 0| 8| 0| 6| 0| 0| 0| 0| 0| 0| 6| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    175MG/KG                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
    LOW FEM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |             +                             +     +                    +  +|             
      Necrosis, Liquifactive               |                                                 3                        |             
      Thalamus, Mineralization             |                                                                      1  1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |             2                                                            |             
      Foreign Body                         |                                                                          |             
      Inflammation, Chronic                |                                                       2                  |             
      Alveolar Epithelium, Hyperplasia     |                                                                      2   |             
      Alveolus, Foreign Body               |                1                                      1                  |             
      Fat, Mediastinum, Necrosis           |                                                                          |             
      Mediastinum, Foreign Body            |                                                                          |             
      Mediastinum, Inflammation, Acute     |                                                                          |             
      Pleura, Inflammation, Acute          |             2                                                            |             
                                            __________________________________________________________________________|             
   Nose                                    |             +                             +     +                    +  +|             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Acute                           |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 |             +                             +     +                    +  +|             
      Peritracheal Tissue, Foreign Body    |             2                                                            |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |    +                                                                     |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                2                                                         |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infarct                              |                   2        1                                             |             
      Metaplasia, Osseous                  |                1                                                         |             
      Mineralization                       |                                                                          |             
      Nephropathy                          |                                                                          |             
      Medulla, Inflammation, Acute         |                                                                          |             
      Renal Tubule, Karyomegaly            |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |             +                             +     +                    M  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  17                                                               
NTP Experiment-Test: 05042-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TRIS (2-CHLOROETHYL) PHOSPHATE                              Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 16:56:49  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 7| 6| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 3| 3| 3| 3| 1| 3| 3| 9| 7| 6| 3| 3| 3| 3| 6| 3| 3| 3| 9| 5| 3| 3| 3| 3| 4|             
                                           | 0| 0| 0| 0| 4| 0| 0| 4| 0| 6| 1| 1| 1| 1| 9| 1| 1| 1| 0| 4| 1| 1| 1| 1| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    175MG/KG                               | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    LOW FEM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |             +        +  +  +              +           +  +              +|             
                                            __________________________________________________________________________|             
   Gallbladder                             |             M        M  +  +              +           +  A              A|             
                                            __________________________________________________________________________|             
   Intestine Large                         |             +        +  +  +              +           +  +              +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |             +        +  +  +              +           M  +              +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |             +        +  +  +              +           +  +              +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |             +        +  +  +              +           M  +              +|             
                                            __________________________________________________________________________|             
   Intestine Small                         |             +        +  +  +              +           +  A              +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |             +        M  M  M              M           M  A              A|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |             +        +  +  +              +           +  A              A|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |             +        +  +  +              +           +  A              +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                          3               |             
      Eosinophilic Focus                   |                   1     1                                                |             
      Hematopoietic Cell Proliferation     |                                                    1                     |             
      Inflammation, Chronic                |                                                                          |             
      Necrosis, Coagulative                |          1                                               3              2|             
      Vacuolization Cytoplasmic            |                                           2                             2|             
                                            __________________________________________________________________________|             
   Mesentery                               |                         +                 +        +              +      |             
      Fat, Necrosis                        |                         3                 4        3                     |             
                                            __________________________________________________________________________|             
   Pancreas                                |             +        +  +  +              +           +  +              +|             
      Acinus, Atrophy                      |             1                                                            |             
      Acinus, Basophilic Focus             |                                                                         1|             
      Duct, Ectasia                        |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |             +        +  +  +              +           +  +              +|             
      Inflammation, Chronic                |                                                                         1|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Squamous                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Tooth                                   |             +        +  +  +              +           +  +              +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |             +        +  +  +              +           +  +              +|             
      Inflammation, Chronic                |                                                                          |             
      Atrium, Thrombosis                   |                                                          2               |             
      Epicardium, Inflammation, Acute      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |             +        +  +  +              M           +  +              +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |             +        +  +  +              M           +  +              +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |             +        +  +  +              M           +  +              +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |             +        +  +  M              +           +  +              +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |             +        +  +  M              +           +  M              +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +           +        +  +  +              M           +  +        +     +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  18                                                               
NTP Experiment-Test: 05042-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TRIS (2-CHLOROETHYL) PHOSPHATE                              Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 16:56:49  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 7| 6| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 3| 3| 3| 3| 1| 3| 3| 9| 7| 6| 3| 3| 3| 3| 6| 3| 3| 3| 9| 5| 3| 3| 3| 3| 4|             
                                           | 0| 0| 0| 0| 4| 0| 0| 4| 0| 6| 1| 1| 1| 1| 9| 1| 1| 1| 0| 4| 1| 1| 1| 1| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    175MG/KG                               | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    LOW FEM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pars Distalis, Hyperplasia           |                                                                         2|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |             +        +  +  +              +           +  M              +|             
      Follicle, Cyst                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +     +     +        +  +  +        +     +           M  +              +|             
      Cyst                                 | 3     3                                                                  |             
                                            __________________________________________________________________________|             
   Uterus                                  |    +  +  +  +  +  +  +  +  +  +  +        +  +  +  +  +  +  +  +  +  +  +|             
      Hydrometra                           |                                                          4               |             
      Endometrium, Hyperplasia, Cystic     |    2  3  4  2  3  2  2  2  3  3  3        3  2  3  3  2     3  3  2  3  2|             
      Endometrium, Inflammation, Acute     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |             +        +  +  +              +           +  +              +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |             +        +  +  +        +     +        +  +  +        +     +|             
      Mediastinal, Hyperplasia, Lymphoid   |                         3                                                |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |             +        +  +  +              +           +  +              +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |             +        +  +  +        +     +        +  M  +        +     +|             
      Hematopoietic Cell Proliferation     |                                           3                              |             
      Inflammation, Chronic                |                                     4                                    |             
                                            __________________________________________________________________________|             
   Spleen                                  |             +        +  +  +        +     M        +  +  +        +     +|             
      Hematopoietic Cell Proliferation     |                                                    1              3     2|             
      Hyperplasia, Lymphoid                |                                     2                                    |             
                                            __________________________________________________________________________|             
   Thymus                                  |             M        +  +  +              M           +  M              +|             
      Mediastinum, Inflammation, Acute     |                                                                          |             
      Thymocyte, Necrosis                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |       +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +              +|             
      Hyperplasia, Cystic                  |                                                                          |             
      Duct, Hyperplasia                    |                   3                                                      |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +        +  +|             
      Fibrosis                             |                                                                          |             
      Inflammation, Acute                  |                                                    1                     |             
      Subcutaneous Tissue, Necrosis        |                                           3                              |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |             +        +  +  +              +           +  +              +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |             +        +  +  +              +           +  +        +     +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  19                                                               
NTP Experiment-Test: 05042-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TRIS (2-CHLOROETHYL) PHOSPHATE                              Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 16:56:49  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 7| 6| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6|             
                             DAY ON TEST   | 3| 3| 3| 3| 1| 3| 3| 9| 7| 6| 3| 3| 3| 3| 6| 3| 3| 3| 9| 5| 3| 3| 3| 3| 4|             
                                           | 0| 0| 0| 0| 4| 0| 0| 4| 0| 6| 1| 1| 1| 1| 9| 1| 1| 1| 0| 4| 1| 1| 1| 1| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    175MG/KG                               | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    LOW FEM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |             +        +  +  +              +           +  +              +|             
      Necrosis, Liquifactive               |                                                                          |             
      Thalamus, Mineralization             |                      1  2                             1  1               |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Foreign Body                         |                                                       2                  |             
      Inflammation, Chronic                |    1                    2                    1                           |             
      Alveolar Epithelium, Hyperplasia     |                3                                                         |             
      Alveolus, Foreign Body               |    1                                                                     |             
      Fat, Mediastinum, Necrosis           |                                           2                              |             
      Mediastinum, Foreign Body            |             2                                                            |             
      Mediastinum, Inflammation, Acute     |             3                                                            |             
      Pleura, Inflammation, Acute          |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |             +  +     +  +  +              +           +  +              +|             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Acute                           |                                                       1                  |             
                                            __________________________________________________________________________|             
   Trachea                                 |             +        +  +  +              +           +  M              +|             
      Peritracheal Tissue, Foreign Body    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |       2                                1                    1            |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Infarct                              |    2                                                                     |             
      Metaplasia, Osseous                  |                                                                          |             
      Mineralization                       |             2                                                            |             
      Nephropathy                          |                                     1                                    |             
      Medulla, Inflammation, Acute         |                                                          2               |             
      Renal Tubule, Karyomegaly            | 1                 1  1                          1                    1   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |             +        +  +  +              +           +  +              +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  20                                                               
NTP Experiment-Test: 05042-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TRIS (2-CHLOROETHYL) PHOSPHATE                              Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 16:56:49  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      A     |
    175MG/KG                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |      L     |
    LOW FEM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |                                                                          |  13        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |                                                                          |   8        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |                                                                          |  13        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |                                                                          |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |                                                                          |  13        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |                                                                          |  11        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |                                                                          |  12        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                                                                          |   9        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                                                                          |  12        |
                                            __________________________________________________________________________|____________|
   Liver                                   |                                                                          |  50        |
      Angiectasis                          |                                                                          |      1  3.0|
      Eosinophilic Focus                   |                                                                          |      3  1.3|
      Hematopoietic Cell Proliferation     |                                                                          |      1  1.0|
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Necrosis, Coagulative                |                                                                          |      3  2.0|
      Vacuolization Cytoplasmic            |                                                                          |      4  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   9        |
      Fat, Necrosis                        |                                                                          |      8  2.9|
                                            __________________________________________________________________________|____________|
   Pancreas                                |                                                                          |  13        |
      Acinus, Atrophy                      |                                                                          |      2  1.5|
      Acinus, Basophilic Focus             |                                                                          |      1  1.0|
      Duct, Ectasia                        |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |                                                                          |  13        |
      Inflammation, Chronic                |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 |                                                                          |  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |                                                                          |  49        |
      Hyperplasia, Squamous                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |                                                                          |  49        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |  13        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |                                                                          |  13        |
      Inflammation, Chronic                |                                                                          |      1  1.0|
      Atrium, Thrombosis                   |                                                                          |      1  2.0|
      Epicardium, Inflammation, Acute      |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |                                                                          |  12        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  21                                                               
NTP Experiment-Test: 05042-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TRIS (2-CHLOROETHYL) PHOSPHATE                              Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 16:56:49  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      A     |
    175MG/KG                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |      L     |
    LOW FEM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |                                                                          |  12        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |                                                                          |  12        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |                                                                          |  12        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |                                                                          |  11        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |                                                                          |  14        |
      Pars Distalis, Hyperplasia           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |                                                                          |  12        |
      Follicle, Cyst                       |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   |                                                                          |  16        |
      Cyst                                 |                                                                          |      6  2.8|
                                            __________________________________________________________________________|____________|
   Uterus                                  |                                                                          |  43        |
      Hydrometra                           |                                                                          |      1  4.0|
      Endometrium, Hyperplasia, Cystic     |                                                                          |     42  2.5|
      Endometrium, Inflammation, Acute     |                                                                          |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |                                                                          |  13        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |  17        |
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |                                                                          |  12        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                                                                          |  16        |
      Hematopoietic Cell Proliferation     |                                                                          |      1  3.0|
      Inflammation, Chronic                |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  |                                                                          |  20        |
      Hematopoietic Cell Proliferation     |                                                                          |      5  2.2|
      Hyperplasia, Lymphoid                |                                                                          |      3  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  |                                                                          |   8        |
      Mediastinum, Inflammation, Acute     |                                                                          |      1  3.0|
      Thymocyte, Necrosis                  |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |                                                                          |  33        |
      Hyperplasia, Cystic                  |                                                                          |      3  2.0|
      Duct, Hyperplasia                    |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  22                                                               
NTP Experiment-Test: 05042-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TRIS (2-CHLOROETHYL) PHOSPHATE                              Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 16:56:49  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      A     |
    175MG/KG                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |      L     |
    LOW FEM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Skin                                    |                                                                          |  48        |
      Fibrosis                             |                                                                          |      1  2.0|
      Inflammation, Acute                  |                                                                          |      3  2.0|
      Subcutaneous Tissue, Necrosis        |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |                                                                          |  13        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |  14        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |                                                                          |  13        |
      Necrosis, Liquifactive               |                                                                          |      1  3.0|
      Thalamus, Mineralization             |                                                                          |      6  1.2|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |                                                                          |  50        |
      Congestion                           |                                                                          |      1  2.0|
      Foreign Body                         |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                                                          |      4  1.5|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      2  2.5|
      Alveolus, Foreign Body               |                                                                          |      3  1.0|
      Fat, Mediastinum, Necrosis           |                                                                          |      1  2.0|
      Mediastinum, Foreign Body            |                                                                          |      1  2.0|
      Mediastinum, Inflammation, Acute     |                                                                          |      1  3.0|
      Pleura, Inflammation, Acute          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    |                                                                          |  14        |
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Acute                           |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 |                                                                          |  12        |
      Peritracheal Tissue, Foreign Body    |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |  49        |
      Hyperplasia                          |                                                                          |      4  1.5|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |                                                                          |  49        |
      Infarct                              |                                                                          |      3  1.7|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  23                                                               
NTP Experiment-Test: 05042-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TRIS (2-CHLOROETHYL) PHOSPHATE                              Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 16:56:49  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      A     |
    175MG/KG                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |      L     |
    LOW FEM                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Metaplasia, Osseous                  |                                                                          |      1  1.0|
      Mineralization                       |                                                                          |      1  2.0|
      Nephropathy                          |                                                                          |      1  1.0|
      Medulla, Inflammation, Acute         |                                                                          |      1  2.0|
      Renal Tubule, Karyomegaly            |                                                                          |      5  1.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |                                                                          |  12        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  24                                                               
NTP Experiment-Test: 05042-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TRIS (2-CHLOROETHYL) PHOSPHATE                              Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 16:56:49  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 4| 7| 7| 6| 6| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6|             
                             DAY ON TEST   | 3| 3| 3| 8| 8| 3| 3| 9| 7| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 9|             
                                           | 1| 1| 1| 9| 2| 1| 1| 8| 6| 2| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 4| 1| 1| 1| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    350MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     HIGHFEM                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  M  +  M  A  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | M  +  M  M  A  +  M  M  M  A  M  +  M  M  M  M  M  M  M  M  A  M  M  M  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Clear Cell Focus                     |                                                                          |             
      Eosinophilic Focus                   |                                                       1                  |             
      Hematopoietic Cell Proliferation     |                                  2                                       |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Subacute               |    2                                                                     |             
      Necrosis, Coagulative                |                                           2                       1      |             
      Vacuolization Cytoplasmic            |          2                                                               |             
                                            __________________________________________________________________________|             
   Mesentery                               |                      +                          +                        |             
      Fat, Necrosis                        |                      3                          3                        |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                   2      |             
      Acinus, Atrophy                      |                4                 1                 1     1               |             
      Acinus, Basophilic Focus             |                      1                                                   |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                         1                    1  2                 1      |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Squamous                |       2           1           4                          4           3   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mucosa, Dilatation                   |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                                                    1                     |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Subacute               |                                                                          |             
      Myocardium, Necrosis, Zenkers        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Ballooning             |       3                                                                  |             
      Hematopoietic Cell Proliferation     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  25                                                               
NTP Experiment-Test: 05042-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TRIS (2-CHLOROETHYL) PHOSPHATE                              Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 16:56:49  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 4| 7| 7| 6| 6| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6|             
                             DAY ON TEST   | 3| 3| 3| 8| 8| 3| 3| 9| 7| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 9|             
                                           | 1| 1| 1| 9| 2| 1| 1| 8| 6| 2| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 4| 1| 1| 1| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    350MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     HIGHFEM                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  M  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Pars Distalis, Angiectasis           |                      2                                                   |             
      Pars Distalis, Hyperplasia           |                2     2                 2                                 |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicular Cell, Hyperplasia         |                      2           3                                1      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  M  +  +  +  M  +  +  M  +  M  M  +  +  +  +  M  +  +  +  +  M  M  M  +|             
      Cyst                                 | 2                    3                 3              2                  |             
      Periovarian Tissue, Inflammation,    |                                                                          |             
           Chronic                         |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Endometrium, Hyperplasia, Cystic     | 4  2  2  1  1  2  3  1  3     3  2  3  2  1  3  2  2  2  4  2  3  2  2  2|             
      Endometrium, Inflammation, Acute     |          3                                                               |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Reticulum Cell          |                                                       1                  |             
      Myelofibrosis                        |    1  1                       1  2                             2         |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia, Lymphoid                |    3                                4                                    |             
                                            __________________________________________________________________________|             
   Spleen                                  | M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                  3        2                              |             
      Hyperplasia, Lymphoid                |    3                                                     1  2            |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  M  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Cyst                                 | 1                                            2                           |             
      Hyperplasia, Lymphoid                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  |                      2        1           2                              |             
      Duct, Ectasia                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  26                                                               
NTP Experiment-Test: 05042-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TRIS (2-CHLOROETHYL) PHOSPHATE                              Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 16:56:49  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 4| 7| 7| 6| 6| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6|             
                             DAY ON TEST   | 3| 3| 3| 8| 8| 3| 3| 9| 7| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 9|             
                                           | 1| 1| 1| 9| 2| 1| 1| 8| 6| 2| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 4| 1| 1| 1| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    350MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     HIGHFEM                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Duct, Hyperplasia                    |       1                                                                  |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Face, Inflammation, Acute            |                                        3                                 |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Head, Inflammation, Acute            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Meninges, Inflammation, Chronic      |                                                                          |             
      Thalamus, Mineralization             |    1           1  1     1     2  1  1           1        1  1           1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                            2                                             |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Leukocytosis                         |                                                                          |             
      Thrombosis                           |    2                                                                     |             
      Alveolar Epithelium, Hyperplasia     |                                  3                                       |             
      Arteriole, Hyperplasia               |                                                                          |             
      Mediastinum, Foreign Body            |                         3     2                                          |             
      Mediastinum, Inflammation, Acute     |                         3                                                |             
      Mediastinum, Inflammation, Chronic   |                               3                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nasolacrimal Duct, Foreign Body      |                                                                         2|             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Acute                           |             2                                                            |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Glands, Dilatation                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |             +                                                            |             
                                            __________________________________________________________________________|             
   Eye                                     |          +                                                               |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infarct                              | 2                                               1                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  27                                                               
NTP Experiment-Test: 05042-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TRIS (2-CHLOROETHYL) PHOSPHATE                              Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 16:56:49  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 4| 4| 7| 7| 6| 6| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6|             
                             DAY ON TEST   | 3| 3| 3| 8| 8| 3| 3| 9| 7| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 9|             
                                           | 1| 1| 1| 9| 2| 1| 1| 8| 6| 2| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 4| 1| 1| 1| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    350MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     HIGHFEM                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Metaplasia, Osseous                  |                                                                          |             
      Nephropathy                          |    1                    1     2                                          |             
      Cortex, Necrosis, Coagulative        |                                                                          |             
      Renal Tubule, Karyomegaly            | 1  1  1        1     1  1     1  1  1  1  1  1  1  1  1  1  1  2  1  1  1|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  28                                                               
NTP Experiment-Test: 05042-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TRIS (2-CHLOROETHYL) PHOSPHATE                              Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 16:56:49  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 5| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 6|             
                             DAY ON TEST   | 3| 3| 3| 8| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 1| 2| 3| 3| 3| 7| 7|             
                                           | 1| 1| 1| 3| 9| 1| 1| 1| 1| 7| 1| 1| 1| 1| 6| 1| 1| 1| 9| 7| 1| 1| 1| 6| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    350MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
     HIGHFEM                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | M  M  M  A  A  M  M  M  M  M  M  M  M  +  M  M  M  M  M  M  +  +  M  A  M|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Clear Cell Focus                     |    1                                                                     |             
      Eosinophilic Focus                   |                                                                          |             
      Hematopoietic Cell Proliferation     |                                     1                                   2|             
      Inflammation, Chronic                |                            2                                             |             
      Inflammation, Subacute               |                                                                   1      |             
      Necrosis, Coagulative                | 2                                                                    3   |             
      Vacuolization Cytoplasmic            |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                     +  +        +  +     +     +     +   |             
      Fat, Necrosis                        |                                     3  3        1  3           2     2   |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Acinus, Atrophy                      |                      1     2                                             |             
      Acinus, Basophilic Focus             |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                           1                              |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Squamous                |          2                    3                                3         |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  A  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mucosa, Dilatation                   |                   1                                                      |             
                                            __________________________________________________________________________|             
   Tooth                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Subacute               |                                                                         3|             
      Myocardium, Necrosis, Zenkers        |                                                                         3|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Ballooning             |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                         3|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  29                                                               
NTP Experiment-Test: 05042-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TRIS (2-CHLOROETHYL) PHOSPHATE                              Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 16:56:49  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 5| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 6|             
                             DAY ON TEST   | 3| 3| 3| 8| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 1| 2| 3| 3| 3| 7| 7|             
                                           | 1| 1| 1| 3| 9| 1| 1| 1| 1| 7| 1| 1| 1| 1| 6| 1| 1| 1| 9| 7| 1| 1| 1| 6| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    350MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
     HIGHFEM                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +  +  +  M  +  M  +  M  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Pars Distalis, Angiectasis           |                                              1     2  2                  |             
      Pars Distalis, Hyperplasia           | 2                                                  1                     |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Follicular Cell, Hyperplasia         |       1                                1              1                  |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | M  +  +  M  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  M  +  M|             
      Cyst                                 |       2                                1           3                     |             
      Periovarian Tissue, Inflammation,    |                                                                          |             
           Chronic                         |                                                          2               |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Endometrium, Hyperplasia, Cystic     | 1  3  2  1  2  3  4  3  3  2  3  3  3  3  2  3  3  3  4  3  3  3  2     2|             
      Endometrium, Inflammation, Acute     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Reticulum Cell          |                                                                          |             
      Myelofibrosis                        |    1     1     1                 2  1        2        2     1  1         |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mediastinal, Hyperplasia, Lymphoid   |                                                             3            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                                         2|             
      Hyperplasia, Lymphoid                | 3                       3                                                |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                                         2|             
      Hyperplasia, Lymphoid                | 2                                                                        |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                           3              3              3|             
      Hyperplasia, Lymphoid                | 4                       3                                         2      |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  M  +  M  +  +  M  +  +  +  +  +  M  +  M  +  +  +  M  +  +  +  +  +  +|             
      Cyst                                 |                            2                                             |             
      Hyperplasia, Lymphoid                |                      3                                                   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +|             
      Hyperplasia, Cystic                  |                                        1                             2   |             
      Duct, Ectasia                        |                                     2                                    |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  30                                                               
NTP Experiment-Test: 05042-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TRIS (2-CHLOROETHYL) PHOSPHATE                              Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 16:56:49  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 5| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 6|             
                             DAY ON TEST   | 3| 3| 3| 8| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 1| 2| 3| 3| 3| 7| 7|             
                                           | 1| 1| 1| 3| 9| 1| 1| 1| 1| 7| 1| 1| 1| 1| 6| 1| 1| 1| 9| 7| 1| 1| 1| 6| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    350MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
     HIGHFEM                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Duct, Hyperplasia                    |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                              1     1                     |             
      Face, Inflammation, Acute            |                               2                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                             2            |             
      Head, Inflammation, Acute            |                                  3                                       |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Meninges, Inflammation, Chronic      |                                                 1                        |             
      Thalamus, Mineralization             |    1           1        1        1        2  1  1     1  1     1     1  1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Inflammation, Acute                  |                                        1                                 |             
      Inflammation, Chronic                | 3                                                  3                     |             
      Leukocytosis                         |                                                                      4   |             
      Thrombosis                           |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |             2        1                                                   |             
      Arteriole, Hyperplasia               | 2                                                                        |             
      Mediastinum, Foreign Body            |                                                       1                  |             
      Mediastinum, Inflammation, Acute     |                                                       3                  |             
      Mediastinum, Inflammation, Chronic   |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nasolacrimal Duct, Foreign Body      |                                                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Acute                           |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Glands, Dilatation                   |                                                                   2      |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                      +  +|             
                                            __________________________________________________________________________|             
   Eye                                     |             +              +                                             |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                        1              2                  |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infarct                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  31                                                               
NTP Experiment-Test: 05042-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TRIS (2-CHLOROETHYL) PHOSPHATE                              Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 16:56:49  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 5| 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 6| 6|             
                             DAY ON TEST   | 3| 3| 3| 8| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 0| 3| 3| 3| 1| 2| 3| 3| 3| 7| 7|             
                                           | 1| 1| 1| 3| 9| 1| 1| 1| 1| 7| 1| 1| 1| 1| 6| 1| 1| 1| 9| 7| 1| 1| 1| 6| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    350MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
     HIGHFEM                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Inflammation, Chronic                |                            4                                             |             
      Metaplasia, Osseous                  |                                  2                                       |             
      Nephropathy                          |          1     1        3  3                       1     2               |             
      Cortex, Necrosis, Coagulative        |                                                       2                  |             
      Renal Tubule, Karyomegaly            | 1  1  1  1  1  1  1  1        1  1  1  2  1  1  2  2  1  1  2  2  2  1  1|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                    1                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  32                                                               
NTP Experiment-Test: 05042-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TRIS (2-CHLOROETHYL) PHOSPHATE                              Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 16:56:49  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |      A     |
    350MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
     HIGHFEM                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |                                                                          |  49        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |                                                                          |  43        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |                                                                          |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |                                                                          |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |                                                                          |  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |                                                                          |   7        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                                                                          |  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                                                                          |  46        |
                                            __________________________________________________________________________|____________|
   Liver                                   |                                                                          |  50        |
      Clear Cell Focus                     |                                                                          |      1  1.0|
      Eosinophilic Focus                   |                                                                          |      1  1.0|
      Hematopoietic Cell Proliferation     |                                                                          |      3  1.7|
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Inflammation, Subacute               |                                                                          |      2  1.5|
      Necrosis, Coagulative                |                                                                          |      4  2.0|
      Vacuolization Cytoplasmic            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   9        |
      Fat, Necrosis                        |                                                                          |      8  2.5|
                                            __________________________________________________________________________|____________|
   Pancreas                                |                                                                          |  48        |
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Acinus, Atrophy                      |                                                                          |      6  1.7|
      Acinus, Basophilic Focus             |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |                                                                          |  48        |
      Inflammation, Chronic                |                                                                          |      5  1.2|
                                            __________________________________________________________________________|____________|
   Stomach                                 |                                                                          |  48        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |                                                                          |  48        |
      Hyperplasia, Squamous                |                                                                          |      8  2.8|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |                                                                          |  47        |
      Mucosa, Dilatation                   |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |  50        |
      Inflammation, Acute                  |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |                                                                          |  49        |
      Inflammation, Subacute               |                                                                          |      1  3.0|
      Myocardium, Necrosis, Zenkers        |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  33                                                               
NTP Experiment-Test: 05042-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TRIS (2-CHLOROETHYL) PHOSPHATE                              Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 16:56:49  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |      A     |
    350MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
     HIGHFEM                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |                                                                          |  50        |
      Degeneration, Ballooning             |                                                                          |      1  3.0|
      Hematopoietic Cell Proliferation     |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |                                                                          |  48        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |                                                                          |  48        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |                                                                          |  41        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |                                                                          |  44        |
      Pars Distalis, Angiectasis           |                                                                          |      4  1.8|
      Pars Distalis, Hyperplasia           |                                                                          |      5  1.8|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |                                                                          |  49        |
      Follicular Cell, Hyperplasia         |                                                                          |      6  1.5|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   |                                                                          |  35        |
      Cyst                                 |                                                                          |      7  2.3|
      Periovarian Tissue, Inflammation,    |                                                                          |            |
           Chronic                         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  |                                                                          |  50        |
      Endometrium, Hyperplasia, Cystic     |                                                                          |     48  2.5|
      Endometrium, Inflammation, Acute     |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |                                                                          |  50        |
      Hyperplasia, Reticulum Cell          |                                                                          |      1  1.0|
      Myelofibrosis                        |                                                                          |     14  1.4|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |  50        |
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |                                                                          |  47        |
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
      Hyperplasia, Lymphoid                |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                                                                          |  48        |
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
      Hyperplasia, Lymphoid                |                                                                          |      3  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  |                                                                          |  48        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  34                                                               
NTP Experiment-Test: 05042-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TRIS (2-CHLOROETHYL) PHOSPHATE                              Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 16:56:49  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |      A     |
    350MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
     HIGHFEM                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Hematopoietic Cell Proliferation     |                                                                          |      5  2.8|
      Hyperplasia, Lymphoid                |                                                                          |      6  2.5|
                                            __________________________________________________________________________|____________|
   Thymus                                  |                                                                          |  40        |
      Cyst                                 |                                                                          |      3  1.7|
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |                                                                          |  45        |
      Hyperplasia, Cystic                  |                                                                          |      5  1.6|
      Duct, Ectasia                        |                                                                          |      1  2.0|
      Duct, Hyperplasia                    |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Skin                                    |                                                                          |  50        |
      Inflammation, Chronic                |                                                                          |      2  1.0|
      Face, Inflammation, Acute            |                                                                          |      2  2.5|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |  50        |
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Head, Inflammation, Acute            |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |                                                                          |  49        |
      Meninges, Inflammation, Chronic      |                                                                          |      1  1.0|
      Thalamus, Mineralization             |                                                                          |     23  1.1|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |                                                                          |  49        |
      Congestion                           |                                                                          |      1  2.0|
      Inflammation, Acute                  |                                                                          |      1  1.0|
      Inflammation, Chronic                |                                                                          |      2  3.0|
      Leukocytosis                         |                                                                          |      1  4.0|
      Thrombosis                           |                                                                          |      1  2.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      3  2.0|
      Arteriole, Hyperplasia               |                                                                          |      1  2.0|
      Mediastinum, Foreign Body            |                                                                          |      3  2.0|
      Mediastinum, Inflammation, Acute     |                                                                          |      2  3.0|
      Mediastinum, Inflammation, Chronic   |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Nose                                    |                                                                          |  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  35                                                               
NTP Experiment-Test: 05042-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TRIS (2-CHLOROETHYL) PHOSPHATE                              Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 16:56:49  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |      A     |
    350MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
     HIGHFEM                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Nasolacrimal Duct, Foreign Body      |                                                                          |      1  2.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Acute                           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 |                                                                          |  50        |
      Glands, Dilatation                   |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   3        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   3        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |  49        |
      Hyperplasia                          |                                                                          |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |                                                                          |  50        |
      Infarct                              |                                                                          |      2  1.5|
      Inflammation, Chronic                |                                                                          |      1  4.0|
      Metaplasia, Osseous                  |                                                                          |      1  2.0|
      Nephropathy                          |                                                                          |      9  1.7|
      Cortex, Necrosis, Coagulative        |                                                                          |      1  2.0|
      Renal Tubule, Karyomegaly            |                                                                          |     44  1.2|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |                                                                          |  49        |
      Inflammation, Chronic                |                                                                          |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  36                                                               
NTP Experiment-Test: 05042-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TRIS (2-CHLOROETHYL) PHOSPHATE                              Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 16:56:49  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 6| 7| 7| 6| 6| 2| 7| 7| 7| 7| 6| 7| 7| 7| 4| 4| 7| 6| 6| 2| 2|             
                             DAY ON TEST   | 2| 2| 2| 9| 6| 1| 1| 8| 5| 5| 2| 2| 2| 2| 7| 2| 2| 2| 8| 5| 2| 8| 5| 9| 9|             
                                           | 9| 9| 9| 7| 5| 5| 4| 8| 4| 0| 9| 9| 9| 9| 5| 9| 9| 9| 5| 1| 9| 1| 6| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Perforation                          |                                                                      3   |             
      Periesophageal Tissue, Foreign Body  |                                                                          |             
      Periesophageal Tissue, Inflammation, |                                                                          |             
           Acute                           |                                                                      3  2|             
      Periesophageal Tissue, Inflammation, |                                                                          |             
           Granulomatous                   |                                                                          |             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  M  +  +  +  +  +  +  +  A  M  +  +  A  +  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +     +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  A  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | M  M  +  M  M  +  A  M  M  M  M  M  +  M  M  +  +  M  A  M  M  +  +  M  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  M  +  +  +  A  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                                                          |             
      Clear Cell Focus                     |    1                                   1                                 |             
      Hematopoietic Cell Proliferation     |                                                          4               |             
      Inflammation, Subacute               |                                                                          |             
      Necrosis, Coagulative                |                                  4                                       |             
      Vacuolization Cytoplasmic            |                                                                      1   |             
                                            __________________________________________________________________________|             
   Mesentery                               | +        +  +                       +  +     +              +  +         |             
      Inflammation, Acute                  |             2                                                            |             
      Fat, Necrosis                        |                                     3  3                    3  3         |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                                                                2         |             
      Acinus, Atrophy                      |    2                                   1           1              1      |             
      Acinus, Vacuolization Cytoplasmic    |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                     1              1              1      |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Squamous                |             2                          2                                 |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |       2                                1                                 |             
      Mucosa, Dilatation                   |                                                    1                     |             
                                            __________________________________________________________________________|             
   Tooth                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dysplasia                            | 1     3        3  3                 1        3     3        3  3  1      |             
      Inflammation, Acute                  |    2                             3                                       |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  37                                                               
NTP Experiment-Test: 05042-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TRIS (2-CHLOROETHYL) PHOSPHATE                              Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 16:56:49  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 6| 7| 7| 6| 6| 2| 7| 7| 7| 7| 6| 7| 7| 7| 4| 4| 7| 6| 6| 2| 2|             
                             DAY ON TEST   | 2| 2| 2| 9| 6| 1| 1| 8| 5| 5| 2| 2| 2| 2| 7| 2| 2| 2| 8| 5| 2| 8| 5| 9| 9|             
                                           | 9| 9| 9| 7| 5| 5| 4| 8| 4| 0| 9| 9| 9| 9| 5| 9| 9| 9| 5| 1| 9| 1| 6| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Subacute               |                                                                          |             
      Atrium, Thrombosis                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Atrophy                              |                                                                          |             
      Degeneration, Ballooning             |                      1                          1  1                     |             
      Hyperplasia, Focal                   |                                                                          |             
      Hyperplasia                          |                                                                          |             
      Hypertrophy                          |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  M  +  M  M  M  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Cyst                  |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                                                                          |             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                                                                +         |             
      Inflammation, Chronic                |                                                                4         |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Inflammation, Acute                  |                                                                3         |             
      Inflammation, Chronic                |                                                       3                  |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |             3                                                            |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Interstitial Cell, Hyperplasia       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                   3      |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                                                                          |             
      Thrombosis                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  38                                                               
NTP Experiment-Test: 05042-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TRIS (2-CHLOROETHYL) PHOSPHATE                              Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 16:56:49  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 6| 7| 7| 6| 6| 2| 7| 7| 7| 7| 6| 7| 7| 7| 4| 4| 7| 6| 6| 2| 2|             
                             DAY ON TEST   | 2| 2| 2| 9| 6| 1| 1| 8| 5| 5| 2| 2| 2| 2| 7| 2| 2| 2| 8| 5| 2| 8| 5| 9| 9|             
                                           | 9| 9| 9| 7| 5| 5| 4| 8| 4| 0| 9| 9| 9| 9| 5| 9| 9| 9| 5| 1| 9| 1| 6| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                 2        3               |             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  M  +  +  +  M  +  M  +  +  M  +  +  M  +  +  M  M  +  +  +  +  +  +  M|             
      Cyst                                 |             2                                                     1      |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  +  M  M  +  M  M  M  M  +  M  M  M  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |             1                                                            |             
      Edema                                |                                                                3         |             
      Fibrosis                             |                                           3                              |             
      Inflammation, Acute                  |             2                                            4               |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation                         |                                                                2         |             
      Pigmentation                         |                                                                          |             
      Face, Foreign Body                   |                                                 2                        |             
      Face, Inflammation, Acute            |                                                 2                        |             
      Subcutaneous Tissue, Abscess         |                                                                      1   |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fracture Healed                      |                                           X                              |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Meninges, Inflammation, Chronic      |                                                                          |             
      Thalamus, Mineralization             |    2        2        1                 1              1           1  1  1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                           2           1                  |             
      Edema                                |                                                                          |             
      Foreign Body                         |                                                       1                  |             
      Inflammation, Chronic                |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Alveolus, Foreign Body               |                   1                                         1            |             
      Alveolus, Infiltration Cellular      |                                        1                                 |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  39                                                               
NTP Experiment-Test: 05042-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TRIS (2-CHLOROETHYL) PHOSPHATE                              Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 16:56:49  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 6| 7| 7| 6| 6| 2| 7| 7| 7| 7| 6| 7| 7| 7| 4| 4| 7| 6| 6| 2| 2|             
                             DAY ON TEST   | 2| 2| 2| 9| 6| 1| 1| 8| 5| 5| 2| 2| 2| 2| 7| 2| 2| 2| 8| 5| 2| 8| 5| 9| 9|             
                                           | 9| 9| 9| 7| 5| 5| 4| 8| 4| 0| 9| 9| 9| 9| 5| 9| 9| 9| 5| 1| 9| 1| 6| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Mediastinum, Foreign Body            |                                           1                             3|             
      Mediastinum, Inflammation, Acute     |                                           2                          1   |             
      Pleura, Foreign Body                 |                         2                                                |             
      Pleura, Inflammation, Acute          |          2              3                                            1   |             
      Pleura, Inflammation, Granulomatous  |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                                                2         |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Peritracheal Tissue, Inflammation,   |                                                                          |             
           Acute                           |                                                                      3   |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                        +                                 |             
      Middle Ear, Inflammation, Acute      |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |          +                 +                             +           +  +|             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Hyperplasia                          |                                     2                             1      |             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infarct                              | 1                                                                        |             
      Metaplasia, Osseous                  |                                                                          |             
      Nephropathy                          |    1                 1                                                   |             
      Glomerulus, Dilatation               |       1                                                                  |             
      Pelvis, Inflammation, Acute          |                                                       2        3         |             
      Renal Tubule, Karyomegaly            |                                                                          |             
      Renal Tubule, Necrosis, Coagulative  |                            3                                             |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                            2                                             |             
      Inflammation, Acute                  |                                                                3         |             
      Inflammation, Chronic                |             3                                         3                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  40                                                               
NTP Experiment-Test: 05042-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TRIS (2-CHLOROETHYL) PHOSPHATE                              Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 16:56:49  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 7| 6| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 6| 6| 6| 0|             
                             DAY ON TEST   | 2| 2| 2| 2| 7| 2| 2| 3| 3| 2| 2| 2| 2| 9| 2| 2| 2| 2| 2| 7| 2| 9| 7| 3| 2|             
                                           | 9| 9| 9| 9| 0| 9| 9| 8| 6| 0| 9| 9| 9| 0| 6| 9| 9| 9| 9| 5| 9| 4| 4| 2| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    CONTROL                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Perforation                          |                                                                          |             
      Periesophageal Tissue, Foreign Body  |                                              2                           |             
      Periesophageal Tissue, Inflammation, |                                                                          |             
           Acute                           |                                                          2               |             
      Periesophageal Tissue, Inflammation, |                                                                          |             
           Granulomatous                   |                                              2                           |             
                                            __________________________________________________________________________|             
   Gallbladder                             | M  +  +  +  +  +  +  A  A  A  +  +  +  +  +  +  M  +  +  +  +  M  +  M  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  M  M  M  +  M  +  M  A  M  +  +  +  M  M  M  M  M  M  +  M  M  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  A  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                                    3                     |             
      Clear Cell Focus                     |    1                                                        2            |             
      Hematopoietic Cell Proliferation     |                                                                2         |             
      Inflammation, Subacute               |                1                                                         |             
      Necrosis, Coagulative                |       1                                                                  |             
      Vacuolization Cytoplasmic            |                                  1              1     1                  |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                        +                                 |             
      Inflammation, Acute                  |                                                                          |             
      Fat, Necrosis                        |                                        1                                 |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Inflammation, Acute                  |                                                                          |             
      Acinus, Atrophy                      |                   4              2  1     1  2        1                  |             
      Acinus, Vacuolization Cytoplasmic    |             1                                                            |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                1        1                 1                 1        1   |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Squamous                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                                                                          |             
      Mucosa, Dilatation                   |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dysplasia                            |    1        1        3           3  2     2  3  3  2        2     1      |             
      Inflammation, Acute                  |       3                                                                  |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  41                                                               
NTP Experiment-Test: 05042-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TRIS (2-CHLOROETHYL) PHOSPHATE                              Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 16:56:49  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 7| 6| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 6| 6| 6| 0|             
                             DAY ON TEST   | 2| 2| 2| 2| 7| 2| 2| 3| 3| 2| 2| 2| 2| 9| 2| 2| 2| 2| 2| 7| 2| 9| 7| 3| 2|             
                                           | 9| 9| 9| 9| 0| 9| 9| 8| 6| 0| 9| 9| 9| 0| 6| 9| 9| 9| 9| 5| 9| 4| 4| 2| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    CONTROL                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Inflammation, Acute                  |                                                          1               |             
      Inflammation, Subacute               |                1                                                         |             
      Atrium, Thrombosis                   | 2                                                                        |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                  2                                       |             
      Degeneration, Ballooning             | 1                                                                        |             
      Hyperplasia, Focal                   |                                        2                                 |             
      Hyperplasia                          |                      2                                                   |             
      Hypertrophy                          |                                                       1                  |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  +  M  M  M  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  M  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +|             
      Pars Distalis, Cyst                  |          2                                                               |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |          1                                                               |             
      Follicular Cell, Hyperplasia         |       2                          1  1                                    |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         |    +  +     +                                            +  +     +      |             
      Inflammation, Chronic                |    2  3     4                                               4     4      |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Interstitial Cell, Hyperplasia       |                                                 2     1                  |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |          2                                                               |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Inflammation, Acute                  |                               2                                          |             
      Thrombosis                           |                               3                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  42                                                               
NTP Experiment-Test: 05042-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TRIS (2-CHLOROETHYL) PHOSPHATE                              Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 16:56:49  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 7| 6| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 6| 6| 6| 0|             
                             DAY ON TEST   | 2| 2| 2| 2| 7| 2| 2| 3| 3| 2| 2| 2| 2| 9| 2| 2| 2| 2| 2| 7| 2| 9| 7| 3| 2|             
                                           | 9| 9| 9| 9| 0| 9| 9| 8| 6| 0| 9| 9| 9| 0| 6| 9| 9| 9| 9| 5| 9| 4| 4| 2| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    CONTROL                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |          4                                                               |             
      Hyperplasia, Lymphoid                |                   3                                               1      |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  M  M  M  M  M  +  +  M  M  +  +  +  M  +  +  +  +  M  +  M  +  +  M  +|             
      Cyst                                 |                               1                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  M  M  M  +  M  +  M  M  M  M  M  +  M  M  M  M  M  M  M  M  +  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                                                          |             
      Edema                                |                                                                          |             
      Fibrosis                             |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |          3                                                               |             
      Inflammation                         |                                                                          |             
      Pigmentation                         |                                                          3               |             
      Face, Foreign Body                   |                                                                          |             
      Face, Inflammation, Acute            |                                                                          |             
      Subcutaneous Tissue, Abscess         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fracture Healed                      |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                               3                                          |             
      Inflammation, Acute                  |                               3                                          |             
      Inflammation, Chronic                |                                                       2                  |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Meninges, Inflammation, Chronic      |                1                                                         |             
      Thalamus, Mineralization             |       1  1                    1  1     1           2     1  2     1      |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                         3|             
      Edema                                |                      2                                                   |             
      Foreign Body                         |                                        2                                 |             
      Inflammation, Chronic                | 2                       2                                      2         |             
      Alveolar Epithelium, Hyperplasia     |                                                 3  1        1     2      |             
      Alveolus, Foreign Body               |       1                                                                  |             
      Alveolus, Infiltration Cellular      |                                                                          |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |          3                                            1                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  43                                                               
NTP Experiment-Test: 05042-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TRIS (2-CHLOROETHYL) PHOSPHATE                              Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 16:56:49  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 7| 6| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 6| 6| 6| 0|             
                             DAY ON TEST   | 2| 2| 2| 2| 7| 2| 2| 3| 3| 2| 2| 2| 2| 9| 2| 2| 2| 2| 2| 7| 2| 9| 7| 3| 2|             
                                           | 9| 9| 9| 9| 0| 9| 9| 8| 6| 0| 9| 9| 9| 0| 6| 9| 9| 9| 9| 5| 9| 4| 4| 2| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    CONTROL                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Mediastinum, Foreign Body            |             2                                            3        2      |             
      Mediastinum, Inflammation, Acute     |             3                                            3        2      |             
      Pleura, Foreign Body                 |                                                                          |             
      Pleura, Inflammation, Acute          |                                                                          |             
      Pleura, Inflammation, Granulomatous  |                      3                 2                                 |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Peritracheal Tissue, Inflammation,   |                                                                          |             
           Acute                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                     +                                    |             
      Middle Ear, Inflammation, Acute      |                                     2                                    |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                         +|             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                   2      |             
      Inflammation, Chronic                |                                                                3         |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infarct                              |                                                                          |             
      Metaplasia, Osseous                  |                                                             1     2      |             
      Nephropathy                          | 3     2     1                 3           1  1              1            |             
      Glomerulus, Dilatation               |                                                                          |             
      Pelvis, Inflammation, Acute          |                                                                         3|             
      Renal Tubule, Karyomegaly            |             1                       1                                    |             
      Renal Tubule, Necrosis, Coagulative  |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Inflammation, Acute                  |                                                                         2|             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  44                                                               
NTP Experiment-Test: 05042-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TRIS (2-CHLOROETHYL) PHOSPHATE                              Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 16:56:49  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 2| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 4| 9| 5| 5| 5| 5| 5|                                            |            |
                                           | 8| 8| 8| 2| 7| 8| 8| 8| 8| 8|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |                                                                          |  48        |
      Perforation                          |                                                                          |      1  3.0|
      Periesophageal Tissue, Foreign Body  |                                                                          |      1  2.0|
      Periesophageal Tissue, Inflammation, |                                                                          |            |
           Acute                           |                                                                          |      3  2.3|
      Periesophageal Tissue, Inflammation, |                                                                          |            |
           Granulomatous                   |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Gallbladder                             |                                                                          |  38        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |                                                                          |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |                                                                          |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |                                                                          |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |                                                                          |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |                                                                          |  16        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                                                                          |  43        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                                                                          |  45        |
                                            __________________________________________________________________________|____________|
   Liver                                   |                                                                          |  50        |
      Basophilic Focus                     |                                                                          |      1  3.0|
      Clear Cell Focus                     |                                                                          |      4  1.3|
      Hematopoietic Cell Proliferation     |                                                                          |      2  3.0|
      Inflammation, Subacute               |                                                                          |      1  1.0|
      Necrosis, Coagulative                |                                                                          |      2  2.5|
      Vacuolization Cytoplasmic            |                                                                          |      4  1.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   9        |
      Inflammation, Acute                  |                                                                          |      1  2.0|
      Fat, Necrosis                        |                                                                          |      5  2.6|
                                            __________________________________________________________________________|____________|
   Pancreas                                |                                                                          |  49        |
      Inflammation, Acute                  |                                                                          |      1  2.0|
      Acinus, Atrophy                      |                                                                          |     10  1.6|
      Acinus, Vacuolization Cytoplasmic    |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |                                                                          |  49        |
      Inflammation, Chronic                |                                                                          |      8  1.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |                                                                          |  49        |
      Hyperplasia, Squamous                |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |                                                                          |  50        |
      Inflammation, Acute                  |                                                                          |      2  1.5|
      Mucosa, Dilatation                   |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  45                                                               
NTP Experiment-Test: 05042-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TRIS (2-CHLOROETHYL) PHOSPHATE                              Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 16:56:49  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 2| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 4| 9| 5| 5| 5| 5| 5|                                            |            |
                                           | 8| 8| 8| 2| 7| 8| 8| 8| 8| 8|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Dysplasia                            |                                                                          |     21  2.2|
      Inflammation, Acute                  |                                                                          |      3  2.7|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |                                                                          |  50        |
      Inflammation, Acute                  |                                                                          |      1  1.0|
      Inflammation, Subacute               |                                                                          |      1  1.0|
      Atrium, Thrombosis                   |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |                                                                          |  48        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |                                                                          |  48        |
      Atrophy                              |                                                                          |      1  2.0|
      Degeneration, Ballooning             |                                                                          |      4  1.0|
      Hyperplasia, Focal                   |                                                                          |      1  2.0|
      Hyperplasia                          |                                                                          |      1  2.0|
      Hypertrophy                          |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |                                                                          |  46        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |                                                                          |  49        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |                                                                          |  36        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |                                                                          |  45        |
      Pars Distalis, Cyst                  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |                                                                          |  49        |
      Inflammation, Acute                  |                                                                          |      1  1.0|
      Follicular Cell, Hyperplasia         |                                                                          |      3  1.3|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              |                                                                          |  49        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                                                                          |   7        |
      Inflammation, Chronic                |                                                                          |      6  3.5|
                                            __________________________________________________________________________|____________|
   Prostate                                |                                                                          |  49        |
      Inflammation, Acute                  |                                                                          |      1  3.0|
      Inflammation, Chronic                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |                                                                          |  48        |
      Inflammation, Chronic                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Testes                                  |                                                                          |  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  46                                                               
NTP Experiment-Test: 05042-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TRIS (2-CHLOROETHYL) PHOSPHATE                              Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 16:56:49  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 2| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 4| 9| 5| 5| 5| 5| 5|                                            |            |
                                           | 8| 8| 8| 2| 7| 8| 8| 8| 8| 8|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Interstitial Cell, Hyperplasia       |                                                                          |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |                                                                          |  50        |
      Atrophy                              |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |                                                                          |  46        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                                                                          |  48        |
      Inflammation, Acute                  |                                                                          |      1  2.0|
      Thrombosis                           |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  |                                                                          |  50        |
      Hematopoietic Cell Proliferation     |                                                                          |      3  3.0|
      Hyperplasia, Lymphoid                |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  |                                                                          |  29        |
      Cyst                                 |                                                                          |      3  1.3|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |                                                                          |   9        |
                                            __________________________________________________________________________|____________|
   Skin                                    |                                                                          |  50        |
      Acanthosis                           |                                                                          |      1  1.0|
      Edema                                |                                                                          |      1  3.0|
      Fibrosis                             |                                                                          |      1  3.0|
      Inflammation, Acute                  |                                                                          |      2  3.0|
      Inflammation, Chronic                |                                                                          |      1  3.0|
      Inflammation                         |                                                                          |      1  2.0|
      Pigmentation                         |                                                                          |      1  3.0|
      Face, Foreign Body                   |                                                                          |      1  2.0|
      Face, Inflammation, Acute            |                                                                          |      1  2.0|
      Subcutaneous Tissue, Abscess         |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |                                                                          |  50        |
      Fracture Healed                      |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |  50        |
      Fibrosis                             |                                                                          |      1  3.0|
      Inflammation, Acute                  |                                                                          |      1  3.0|
      Inflammation, Chronic                |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  47                                                               
NTP Experiment-Test: 05042-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TRIS (2-CHLOROETHYL) PHOSPHATE                              Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 16:56:49  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 2| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 4| 9| 5| 5| 5| 5| 5|                                            |            |
                                           | 8| 8| 8| 2| 7| 8| 8| 8| 8| 8|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |                                                                          |  50        |
      Meninges, Inflammation, Chronic      |                                                                          |      1  1.0|
      Thalamus, Mineralization             |                                                                          |     17  1.2|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |                                                                          |  50        |
      Congestion                           |                                                                          |      3  2.0|
      Edema                                |                                                                          |      1  2.0|
      Foreign Body                         |                                                                          |      2  1.5|
      Inflammation, Chronic                |                                                                          |      3  2.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      4  1.8|
      Alveolus, Foreign Body               |                                                                          |      3  1.0|
      Alveolus, Infiltration Cellular      |                                                                          |      1  1.0|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |                                                                          |      2  2.0|
      Mediastinum, Foreign Body            |                                                                          |      5  2.2|
      Mediastinum, Inflammation, Acute     |                                                                          |      5  2.2|
      Pleura, Foreign Body                 |                                                                          |      1  2.0|
      Pleura, Inflammation, Acute          |                                                                          |      3  2.0|
      Pleura, Inflammation, Granulomatous  |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Nose                                    |                                                                          |  50        |
      Foreign Body                         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 |                                                                          |  49        |
      Peritracheal Tissue, Inflammation,   |                                                                          |            |
           Acute                           |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   2        |
      Middle Ear, Inflammation, Acute      |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   6        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |  48        |
      Hyperplasia                          |                                                                          |      3  1.7|
      Inflammation, Chronic                |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |                                                                          |  50        |
      Infarct                              |                                                                          |      1  1.0|
      Metaplasia, Osseous                  |                                                                          |      2  1.5|
      Nephropathy                          |                                                                          |      9  1.6|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  48                                                               
NTP Experiment-Test: 05042-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TRIS (2-CHLOROETHYL) PHOSPHATE                              Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 16:56:49  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 2| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 4| 9| 5| 5| 5| 5| 5|                                            |            |
                                           | 8| 8| 8| 2| 7| 8| 8| 8| 8| 8|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Glomerulus, Dilatation               |                                                                          |      1  1.0|
      Pelvis, Inflammation, Acute          |                                                                          |      3  2.7|
      Renal Tubule, Karyomegaly            |                                                                          |      2  1.0|
      Renal Tubule, Necrosis, Coagulative  |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |                                                                          |  50        |
      Hemorrhage                           |                                                                          |      1  2.0|
      Inflammation, Acute                  |                                                                          |      2  2.5|
      Inflammation, Chronic                |                                                                          |      2  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  49                                                               
NTP Experiment-Test: 05042-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TRIS (2-CHLOROETHYL) PHOSPHATE                              Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 16:56:49  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 6| 2| 7| 6| 6| 6| 4| 7| 7| 7| 6| 6| 7| 7| 7| 6| 3|             
                             DAY ON TEST   | 2| 2| 2| 2| 2| 3| 3| 3| 9| 9| 3| 6| 5| 3| 8| 3| 3| 3| 6| 2| 3| 3| 3| 2| 8|             
                                           | 9| 9| 9| 9| 3| 0| 0| 0| 4| 7| 0| 3| 3| 8| 0| 0| 0| 0| 3| 6| 0| 0| 0| 0| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    175MG/KG                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    LOW MALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |             M           +  +     +  +  +  +           +  +           +  +|             
      Periesophageal Tissue, Foreign Body  |                            2                                            2|             
      Periesophageal Tissue, Inflammation, |                                                                          |             
           Acute                           |                            3                                             |             
      Periesophageal Tissue, Inflammation, |                                                                          |             
           Chronic                         |                                                                          |             
      Periesophageal Tissue, Inflammation, |                                                                          |             
           Granulomatous                   |                                                                         2|             
                                            __________________________________________________________________________|             
   Gallbladder                             |             +           M  +     +  M  M  M           +  +           +  A|             
                                            __________________________________________________________________________|             
   Intestine Large                         |             +           +  +     +  +  +  +           +  +  +        +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |             +           +  +     +  +  +  +           +  +  +        +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |             +           +  +     +  +  +  +           +  +  +        +  +|             
      Inflammation, Acute                  |                                                             2            |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |             +           +  +     +  +  +  +           +  +  +        +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         |             +           +  +     +  A  +  +     +     +  +  +        +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |             A           M  M     M  A  M  A           M  M  M        M  A|             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |             +           +  +     +  A  +  +           +  +  +        +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |             A           +  +     +  A  +  +     +     +  +  +        +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                                                                          |             
      Basophilic Focus                     |                                                             2            |             
      Clear Cell Focus                     |                                                                          |             
      Eosinophilic Focus                   |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                         1|             
      Hyperplasia, Chronic, Lymphoid       |                                                                          |             
      Mixed Cell Focus                     |                               3                             3            |             
      Necrosis, Coagulative                |          1  3                          3                                 |             
      Vacuolization Cytoplasmic            |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                              +                           |             
      Fat, Necrosis                        |                                              3                           |             
                                            __________________________________________________________________________|             
   Pancreas                                | +           +           +  +     +  +  +  +           +  +           +  +|             
      Acinus, Atrophy                      | 2                                      1                                 |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |             +           +  +     +  +  +  +           +  +           +  +|             
      Inflammation, Chronic                |                                                                      1   |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                           2                              |             
      Hyperplasia, Squamous                |                                              2                 1         |             
      Infiltration Cellular, Mast Cell     |                      2                                                   |             
      Inflammation, Acute                  |                                              1                    3      |             
      Ulcer                                |                                           2                              |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  50                                                               
NTP Experiment-Test: 05042-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TRIS (2-CHLOROETHYL) PHOSPHATE                              Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 16:56:49  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 6| 2| 7| 6| 6| 6| 4| 7| 7| 7| 6| 6| 7| 7| 7| 6| 3|             
                             DAY ON TEST   | 2| 2| 2| 2| 2| 3| 3| 3| 9| 9| 3| 6| 5| 3| 8| 3| 3| 3| 6| 2| 3| 3| 3| 2| 8|             
                                           | 9| 9| 9| 9| 3| 0| 0| 0| 4| 7| 0| 3| 3| 8| 0| 0| 0| 0| 3| 6| 0| 0| 0| 0| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    175MG/KG                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    LOW MALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Mucosa, Dilatation                   |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |             +           +  +     +  +  +  +           +  +           +  +|             
      Dysplasia                            |                                  2                                       |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |             +           +  +     +  +  +  +           +  +           +  +|             
      Mineralization                       |                                        1                                 |             
      Atrium, Thrombosis                   |                                     3                                    |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |             +           +  +     +  M  +  +           +  +           +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |             +           +  +     +  M  +  +           +  +           +  +|             
      Hyperplasia, Focal                   |                                                                          |             
      Spindle Cell, Hyperplasia            |                         2                                                |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |             +           +  +     +  M  +  +           +  +           +  +|             
      Hyperplasia                          |                         3                                                |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |             +           +  +     +  +  +  +           +  +           +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |             +           +  +     +  M  +  +           +  +           +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |             +           +  +     +  +  +  +           M  +           +  +|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |             +           +  +     +  +  +  +           +  +           +  +|             
      Ultimobranchial Cyst                 |             3                                                            |             
      Follicle, Cyst                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |             +           +  +     +  +  +  +           +  +           +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                         +  +                                             |             
                                            __________________________________________________________________________|             
   Prostate                                |             +           +  +     +  +  +  +           M  +           M  +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |             +           +  +     +  +  +  +           +  +           +  +|             
      Concretion                           |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  |             +           +  +     +  +  +  +           +  +           +  +|             
      Seminiferous Tubule, Atrophy         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |             +           +  +     +  +  +  +           +  +           +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +           +           +  +     +  +  +  +           +  +           +  +|             
      Mediastinal, Inflammation, Acute     |                                                                         3|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |             +           +  +     +  +  +  M           +  +           +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +           +           +  +     +  +  M  +           +  M           +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  |             +           +  +     +  +  +  +           +  +           +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  51                                                               
NTP Experiment-Test: 05042-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TRIS (2-CHLOROETHYL) PHOSPHATE                              Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 16:56:49  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 6| 2| 7| 6| 6| 6| 4| 7| 7| 7| 6| 6| 7| 7| 7| 6| 3|             
                             DAY ON TEST   | 2| 2| 2| 2| 2| 3| 3| 3| 9| 9| 3| 6| 5| 3| 8| 3| 3| 3| 6| 2| 3| 3| 3| 2| 8|             
                                           | 9| 9| 9| 9| 3| 0| 0| 0| 4| 7| 0| 3| 3| 8| 0| 0| 0| 0| 3| 6| 0| 0| 0| 0| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    175MG/KG                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    LOW MALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Amyloid Deposition                   |                                                                          |             
      Hematopoietic Cell Proliferation     |             3                                                           3|             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  |             M           M  M     +  M  +  +           M  +           +  +|             
      Thymocyte, Necrosis                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |             M     +     M  M     M  M  M  M           M  M           M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +        +  +  +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                                    2                     |             
      Inflammation, Acute                  |                                                    1                     |             
      Inflammation, Chronic                |                2                                                         |             
      Subcutaneous Tissue, Abscess         |                                  3                                      4|             
      Subcutaneous Tissue, Foreign Body    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |             +           +  +     +  +  +  +           +  +           +  +|             
      Tibia, Hyperostosis                  |                         X                                                |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |             +           +  +     +  +  +  +           +  +           +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |             +           +  +     +  +  +  +           +  +           +  +|             
      Thalamus, Mineralization             |             1              1     1  1     1                          1   |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                         +                                                |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                      2                                                   |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |       3                                                  2               |             
      Mediastinum, Foreign Body            |                                                                          |             
      Mediastinum, Inflammation, Acute     |                                                                          |             
      Pleura, Inflammation, Acute          |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |             +           +  +     +  +  +  +           +  +           +  +|             
      Foreign Body                         |                                                                         2|             
                                            __________________________________________________________________________|             
   Trachea                                 |             +           +  +     +  +  +  +           +  +           +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  52                                                               
NTP Experiment-Test: 05042-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TRIS (2-CHLOROETHYL) PHOSPHATE                              Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 16:56:49  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 6| 2| 7| 6| 6| 6| 4| 7| 7| 7| 6| 6| 7| 7| 7| 6| 3|             
                             DAY ON TEST   | 2| 2| 2| 2| 2| 3| 3| 3| 9| 9| 3| 6| 5| 3| 8| 3| 3| 3| 6| 2| 3| 3| 3| 2| 8|             
                                           | 9| 9| 9| 9| 3| 0| 0| 0| 4| 7| 0| 3| 3| 8| 0| 0| 0| 0| 3| 6| 0| 0| 0| 0| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    175MG/KG                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    LOW MALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                            +                                            +|             
      Lens, Cataract                       |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |       1                                                                  |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                                                                          |             
      Infarct                              |             1                                                            |             
      Metaplasia, Osseous                  |                      1        2                             1            |             
      Nephropathy                          |          1     1              1     2                             1  1   |             
      Renal Tubule, Karyomegaly            | 1        1  1        1        1        1        1              1         |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |             +           +  +     +  +  +  +           +  +           +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  53                                                               
NTP Experiment-Test: 05042-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TRIS (2-CHLOROETHYL) PHOSPHATE                              Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 16:56:49  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 5| 7| 7| 7| 6| 2| 7| 7| 6| 6| 6| 7| 7| 7| 6| 0| 7| 7| 6| 6| 6|             
                             DAY ON TEST   | 3| 3| 3| 7| 3| 3| 3| 1| 6| 8| 3| 3| 7| 6| 2| 3| 3| 1| 8| 0| 3| 3| 7| 5| 4|             
                                           | 0| 0| 0| 2| 2| 0| 0| 2| 4| 9| 0| 0| 3| 9| 6| 0| 0| 8| 8| 3| 0| 0| 9| 5| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    175MG/KG                               | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    LOW MALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |          +  +        +  M  +        +  +  +        +  +  +        +  +  +|             
      Periesophageal Tissue, Foreign Body  |                            1                                             |             
      Periesophageal Tissue, Inflammation, |                                                                          |             
           Acute                           |                            2                             3               |             
      Periesophageal Tissue, Inflammation, |                                                                          |             
           Chronic                         |          3           3                                                   |             
      Periesophageal Tissue, Inflammation, |                                                                          |             
           Granulomatous                   |                                                                          |             
                                            __________________________________________________________________________|             
   Gallbladder                             |          +  M        +  M  A        M  M  +        M  +  +        +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         |          +  +        +  +  +        +  +  +        +  +  +        +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |          +  +        +  +  +        M  +  +        +  +  +        +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |          +  +        +  +  +        +  +  +        +  +  +        +  +  +|             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |          +  +        +  +  +        +  +  +        +  +  +        +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         |          +  A        +  +  +        +  +  +        +  +  +        +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |          +  A        +  +  M        M  M  M        +  +  +        M  +  M|             
      Inflammation, Chronic                |          2                                                               |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |          +  A        +  M  +        +  +  +        +  +  +        +  +  +|             
      Hyperplasia, Lymphoid                |                                                                   3      |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |          +  A        +  +  +        +  +  +        +  +  +        +  A  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                                                                   4      |             
      Basophilic Focus                     |          2                                                               |             
      Clear Cell Focus                     | 2                                                                        |             
      Eosinophilic Focus                   |                      2                 2                       2         |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia, Chronic, Lymphoid       |                                                                4         |             
      Mixed Cell Focus                     |                                                                          |             
      Necrosis, Coagulative                |                                                    2                     |             
      Vacuolization Cytoplasmic            | 1                          1                                             |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                  +                                       |             
      Fat, Necrosis                        |                                  3                                       |             
                                            __________________________________________________________________________|             
   Pancreas                                |          +  +        +  +  +        +  +  +        +  +  +        +  +  +|             
      Acinus, Atrophy                      |                                        2                                 |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |          +  +        M  +  +        +  +  +        +  +  +        +  +  +|             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Hyperplasia, Squamous                |                                  3                                       |             
      Infiltration Cellular, Mast Cell     |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  54                                                               
NTP Experiment-Test: 05042-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TRIS (2-CHLOROETHYL) PHOSPHATE                              Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 16:56:49  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 5| 7| 7| 7| 6| 2| 7| 7| 6| 6| 6| 7| 7| 7| 6| 0| 7| 7| 6| 6| 6|             
                             DAY ON TEST   | 3| 3| 3| 7| 3| 3| 3| 1| 6| 8| 3| 3| 7| 6| 2| 3| 3| 1| 8| 0| 3| 3| 7| 5| 4|             
                                           | 0| 0| 0| 2| 2| 0| 0| 2| 4| 9| 0| 0| 3| 9| 6| 0| 0| 8| 8| 3| 0| 0| 9| 5| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    175MG/KG                               | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    LOW MALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Mucosa, Dilatation                   |                                                                   3      |             
                                            __________________________________________________________________________|             
   Tooth                                   |          +  +        +  +  +        +  +  +        +  +  +        +  +  +|             
      Dysplasia                            |                      3  2           3                             1  3   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |          +  +        +  +  +        +  +  +        +  +  +        +  +  +|             
      Mineralization                       |                                                                          |             
      Atrium, Thrombosis                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |          +  +        +  +  +        +  +  +        +  +  +        M  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |          +  +        +  +  +        +  +  +        +  +  +        M  +  +|             
      Hyperplasia, Focal                   |                      1                                                   |             
      Spindle Cell, Hyperplasia            |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |          +  +        +  +  +        +  +  +        +  +  +        M  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |          +  +        +  +  +        +  +  +        +  +  +        +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |          +  M        +  M  M        +  M  M        +  +  M        +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |          +  +        +  +  +        M  +  +        +  M  +        +  +  +|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |          +  +        +  M  M        +  +  +        +  +  +        +  +  +|             
      Ultimobranchial Cyst                 |                                                                          |             
      Follicle, Cyst                       |                                                    2                     |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |          +  +        +  +  M        +  +  +        +  +  +        +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                                                          +               |             
                                            __________________________________________________________________________|             
   Prostate                                |          +  +        +  +  +        +  +  +        +  +  +        +  +  +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |          +  +     +  +  +  +        +  +  +        +  +  +        +  +  +|             
      Concretion                           |                                     3                                    |             
                                            __________________________________________________________________________|             
   Testes                                  |          +  +        +  +  M        +  +  +        +  +  +        +  +  +|             
      Seminiferous Tubule, Atrophy         |          3                                                               |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |          +  +        +  +  +        +  +  +        +  +  +        +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |          +  +  +     +  +  +        +  +  +        +  +  +        +  +  +|             
      Mediastinal, Inflammation, Acute     |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |          +  +        M  +  +        +  +  +        +  +  +        M  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |          +  +  +     +  +  +        +  +  +        +  +  +        +  M  +|             
      Hyperplasia, Lymphoid                |                3                                                         |             
      Inflammation, Chronic                |                                                                   3      |             
                                            __________________________________________________________________________|             
   Spleen                                  | +        +  +  +     +  +  +        +  +  +        +  +  +     +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  55                                                               
NTP Experiment-Test: 05042-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TRIS (2-CHLOROETHYL) PHOSPHATE                              Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 16:56:49  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 5| 7| 7| 7| 6| 2| 7| 7| 6| 6| 6| 7| 7| 7| 6| 0| 7| 7| 6| 6| 6|             
                             DAY ON TEST   | 3| 3| 3| 7| 3| 3| 3| 1| 6| 8| 3| 3| 7| 6| 2| 3| 3| 1| 8| 0| 3| 3| 7| 5| 4|             
                                           | 0| 0| 0| 2| 2| 0| 0| 2| 4| 9| 0| 0| 3| 9| 6| 0| 0| 8| 8| 3| 0| 0| 9| 5| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    175MG/KG                               | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    LOW MALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Amyloid Deposition                   |                                                                   1      |             
      Hematopoietic Cell Proliferation     |                                           3                             2|             
      Hyperplasia, Lymphoid                | 3                                                              2         |             
                                            __________________________________________________________________________|             
   Thymus                                  |          M  M        +  +  +        +  M  +        +  +  +        +  +  +|             
      Thymocyte, Necrosis                  |                            2                       2                 1   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |          M  M        M  M  +        M  +  +        +  M  +        M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    |          +  +     +  +  +  +        +  +  +        +  +  +        +  M  +|             
      Acanthosis                           |                                                                          |             
      Inflammation, Acute                  |                                                                   3      |             
      Inflammation, Chronic                |                                                                          |             
      Subcutaneous Tissue, Abscess         |                                                                          |             
      Subcutaneous Tissue, Foreign Body    |                                                          1               |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |          +  +        +  +  +        +  +  +        +  +  +        +  +  +|             
      Tibia, Hyperostosis                  |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |          +  +        +  +  +        +  +  +        +  +  +        +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |          +  +        +  +  +        +  +  +        +  +  +        +  +  +|             
      Thalamus, Mineralization             |          1  1        1     1        1  1  1                       2      |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                            2                                             |             
      Hemorrhage                           |                      2                                                   |             
      Inflammation, Acute                  |                                           1                              |             
      Inflammation, Chronic                |                                                             2            |             
      Alveolar Epithelium, Hyperplasia     |                         2                                   2            |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      | 3     1                 3                                                |             
      Mediastinum, Foreign Body            |          2              2                                                |             
      Mediastinum, Inflammation, Acute     |          3              3                                                |             
      Pleura, Inflammation, Acute          |                            1                             1               |             
                                            __________________________________________________________________________|             
   Nose                                    |          +  +        +  +  +        +  +  +        +  +  +        +  +  +|             
      Foreign Body                         |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 |          +  +        +  M  +        +  +  +        +  +  +        +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                       +                  |             
      Inflammation, Acute                  |                                                       3                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  56                                                               
NTP Experiment-Test: 05042-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TRIS (2-CHLOROETHYL) PHOSPHATE                              Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 16:56:49  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 5| 5| 7| 7| 7| 6| 2| 7| 7| 6| 6| 6| 7| 7| 7| 6| 0| 7| 7| 6| 6| 6|             
                             DAY ON TEST   | 3| 3| 3| 7| 3| 3| 3| 1| 6| 8| 3| 3| 7| 6| 2| 3| 3| 1| 8| 0| 3| 3| 7| 5| 4|             
                                           | 0| 0| 0| 2| 2| 0| 0| 2| 4| 9| 0| 0| 3| 9| 6| 0| 0| 8| 8| 3| 0| 0| 9| 5| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    175MG/KG                               | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    LOW MALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |             +              +                          +                  |             
      Lens, Cataract                       |                            2                                             |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                      1                                      2            |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                                                                   3      |             
      Infarct                              |                         2                                                |             
      Metaplasia, Osseous                  |                                                                   1     1|             
      Nephropathy                          |          3                                                               |             
      Renal Tubule, Karyomegaly            | 1  1  1        1  1                          1  1  1                     |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |          +  +        +  +  +        +  +  +        +  I  +        +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  57                                                               
NTP Experiment-Test: 05042-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TRIS (2-CHLOROETHYL) PHOSPHATE                              Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 16:56:49  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    175MG/KG                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
    LOW MALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |                                                                          |  23        |
      Periesophageal Tissue, Foreign Body  |                                                                          |      3  1.7|
      Periesophageal Tissue, Inflammation, |                                                                          |            |
           Acute                           |                                                                          |      3  2.7|
      Periesophageal Tissue, Inflammation, |                                                                          |            |
           Chronic                         |                                                                          |      2  3.0|
      Periesophageal Tissue, Inflammation, |                                                                          |            |
           Granulomatous                   |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Gallbladder                             |                                                                          |  14        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |                                                                          |  26        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |                                                                          |  25        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |                                                                          |  26        |
      Inflammation, Acute                  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |                                                                          |  26        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |                                                                          |  25        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |                                                                          |   7        |
      Inflammation, Chronic                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                                                                          |  23        |
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                                                                          |  23        |
                                            __________________________________________________________________________|____________|
   Liver                                   |                                                                          |  50        |
      Amyloid Deposition                   |                                                                          |      1  4.0|
      Basophilic Focus                     |                                                                          |      2  2.0|
      Clear Cell Focus                     |                                                                          |      1  2.0|
      Eosinophilic Focus                   |                                                                          |      3  2.0|
      Hematopoietic Cell Proliferation     |                                                                          |      1  1.0|
      Hyperplasia, Chronic, Lymphoid       |                                                                          |      1  4.0|
      Mixed Cell Focus                     |                                                                          |      2  3.0|
      Necrosis, Coagulative                |                                                                          |      4  2.3|
      Vacuolization Cytoplasmic            |                                                                          |      2  1.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   2        |
      Fat, Necrosis                        |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                |                                                                          |  26        |
      Acinus, Atrophy                      |                                                                          |      3  1.7|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |                                                                          |  24        |
      Inflammation, Chronic                |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |                                                                          |  50        |
      Hyperplasia                          |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  58                                                               
NTP Experiment-Test: 05042-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TRIS (2-CHLOROETHYL) PHOSPHATE                              Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 16:56:49  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    175MG/KG                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
    LOW MALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia, Squamous                |                                                                          |      3  2.0|
      Infiltration Cellular, Mast Cell     |                                                                          |      1  2.0|
      Inflammation, Acute                  |                                                                          |      2  2.0|
      Ulcer                                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |                                                                          |  47        |
      Mucosa, Dilatation                   |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |  25        |
      Dysplasia                            |                                                                          |      6  2.3|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |                                                                          |  25        |
      Mineralization                       |                                                                          |      1  1.0|
      Atrium, Thrombosis                   |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |                                                                          |  23        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |                                                                          |  23        |
      Hyperplasia, Focal                   |                                                                          |      1  1.0|
      Spindle Cell, Hyperplasia            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |                                                                          |  23        |
      Hyperplasia                          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |                                                                          |  25        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |                                                                          |  18        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |                                                                          |  22        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |                                                                          |  23        |
      Ultimobranchial Cyst                 |                                                                          |      1  3.0|
      Follicle, Cyst                       |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              |                                                                          |  24        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                                                                          |   3        |
                                            __________________________________________________________________________|____________|
   Prostate                                |                                                                          |  23        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |                                                                          |  26        |
      Concretion                           |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Testes                                  |                                                                          |  24        |
      Seminiferous Tubule, Atrophy         |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  59                                                               
NTP Experiment-Test: 05042-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TRIS (2-CHLOROETHYL) PHOSPHATE                              Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 16:56:49  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    175MG/KG                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
    LOW MALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |                                                                          |  25        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |  27        |
      Mediastinal, Inflammation, Acute     |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |                                                                          |  22        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                                                                          |  24        |
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
      Inflammation, Chronic                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  |                                                                          |  28        |
      Amyloid Deposition                   |                                                                          |      1  1.0|
      Hematopoietic Cell Proliferation     |                                                                          |      4  2.8|
      Hyperplasia, Lymphoid                |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Thymus                                  |                                                                          |  17        |
      Thymocyte, Necrosis                  |                                                                          |      3  1.7|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |                                                                          |   6        |
                                            __________________________________________________________________________|____________|
   Skin                                    |                                                                          |  35        |
      Acanthosis                           |                                                                          |      1  2.0|
      Inflammation, Acute                  |                                                                          |      2  2.0|
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Subcutaneous Tissue, Abscess         |                                                                          |      2  3.5|
      Subcutaneous Tissue, Foreign Body    |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |                                                                          |  25        |
      Tibia, Hyperostosis                  |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |  25        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |                                                                          |  25        |
      Thalamus, Mineralization             |                                                                          |     14  1.1|
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |                                                                          |  50        |
      Congestion                           |                                                                          |      1  2.0|
      Hemorrhage                           |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  60                                                               
NTP Experiment-Test: 05042-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TRIS (2-CHLOROETHYL) PHOSPHATE                              Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 16:56:49  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    175MG/KG                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
    LOW MALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Acute                  |                                                                          |      1  1.0|
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      3  2.0|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |                                                                          |      5  2.4|
      Mediastinum, Foreign Body            |                                                                          |      2  2.0|
      Mediastinum, Inflammation, Acute     |                                                                          |      2  3.0|
      Pleura, Inflammation, Acute          |                                                                          |      2  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    |                                                                          |  25        |
      Foreign Body                         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 |                                                                          |  24        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
      Inflammation, Acute                  |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   5        |
      Lens, Cataract                       |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |  49        |
      Hyperplasia                          |                                                                          |      3  1.3|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |                                                                          |  50        |
      Amyloid Deposition                   |                                                                          |      1  3.0|
      Infarct                              |                                                                          |      2  1.5|
      Metaplasia, Osseous                  |                                                                          |      5  1.2|
      Nephropathy                          |                                                                          |      7  1.4|
      Renal Tubule, Karyomegaly            |                                                                          |     16  1.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |                                                                          |  24        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  61                                                               
NTP Experiment-Test: 05042-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TRIS (2-CHLOROETHYL) PHOSPHATE                              Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 16:56:49  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 5| 7| 7| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 7| 5| 5| 7| 7| 6| 6| 1|             
                             DAY ON TEST   | 3| 3| 6| 0| 8| 3| 3| 3| 3| 7| 3| 3| 3| 6| 2| 3| 3| 3| 7| 1| 3| 3| 7| 6| 3|             
                                           | 0| 0| 6| 4| 8| 0| 0| 0| 0| 3| 0| 0| 0| 6| 7| 0| 0| 0| 1| 1| 0| 0| 3| 6| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    350MG/KG                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    HIGHMALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Periesophageal Tissue, Foreign Body  |                                                                          |             
      Periesophageal Tissue, Inflammation, |                                                                          |             
           Acute                           |                                                                          |             
                                            __________________________________________________________________________|             
   Gallbladder                             | M  +  +  M  M  +  M  +  M  M  +  M  +  +  +  +  +  +  M  A  +  +  +  M  A|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  A  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | M  +  M  A  A  M  M  +  M  M  M  M  M  M  M  M  M  M  +  A  M  M  M  M  A|             
      Inflammation, Necrotizing            |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  A|             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                           2                          2   |             
      Basophilic Focus                     |                                                                          |             
      Clear Cell Focus                     |                   3  1                       1  3                        |             
      Cytomegaly                           |                                                                3         |             
      Eosinophilic Focus                   |                   2                    2     3        3                  |             
      Mitotic Alteration                   |                                                                2         |             
      Mixed Cell Focus                     |                                     3                                    |             
      Necrosis, Coagulative                | 4                                                                        |             
      Vacuolization Cytoplasmic            |                1                                                         |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                    +                 +   |             
      Hemorrhage                           |                                                    2                     |             
      Fat, Necrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Acinus, Atrophy                      |                1                 1              1                        |             
      Acinus, Basophilic Focus             |                                                                          |             
      Acinus, Hyperplasia                  |                                                                          |             
      Acinus, Vacuolization Cytoplasmic    |                                                                1         |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |    2           1  1  1                       1              1            |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Hyperplasia, Squamous                |                                                          2  1            |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Inflammation, Acute                  |                         1                                                |             
      Mucosa, Dilatation                   |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dysplasia                            | 2  3  1           3  3        2              3  3     1           2      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  62                                                               
NTP Experiment-Test: 05042-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TRIS (2-CHLOROETHYL) PHOSPHATE                              Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 16:56:49  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 5| 7| 7| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 7| 5| 5| 7| 7| 6| 6| 1|             
                             DAY ON TEST   | 3| 3| 6| 0| 8| 3| 3| 3| 3| 7| 3| 3| 3| 6| 2| 3| 3| 3| 7| 1| 3| 3| 7| 6| 3|             
                                           | 0| 0| 6| 4| 8| 0| 0| 0| 0| 3| 0| 0| 0| 6| 7| 0| 0| 0| 1| 1| 0| 0| 3| 6| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    350MG/KG                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    HIGHMALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Inflammation, Acute                  |                3                                                         |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Subacute               |                                                                   1      |             
      Atrium, Thrombosis                   |                            2     3                                       |             
      Myocardium, Degeneration             |                                                                      2   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Atrophy                              |                                                                          |             
      Hypertrophy, Focal                   |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Hyperplasia                          |                                                    1                     |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  M  +  +  M  +  +  +  +  M  M  M  M  M  M  +  +  M  +  +  M  +  M  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Ultimobranchial Cyst                 |                                                                          |             
      Follicular Cell, Hyperplasia         |                         1                                1               |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                      +                          +                        |             
      Inflammation, Chronic                |                      3                                                   |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Seminiferous Tubule, Atrophy         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                           +                              |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Renal, Hyperplasia, Lymphoid         |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Plasma Cell   |                               2                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  M  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  M  M|             
      Angiectasis                          |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  63                                                               
NTP Experiment-Test: 05042-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TRIS (2-CHLOROETHYL) PHOSPHATE                              Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 16:56:49  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 5| 7| 7| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 7| 5| 5| 7| 7| 6| 6| 1|             
                             DAY ON TEST   | 3| 3| 6| 0| 8| 3| 3| 3| 3| 7| 3| 3| 3| 6| 2| 3| 3| 3| 7| 1| 3| 3| 7| 6| 3|             
                                           | 0| 0| 6| 4| 8| 0| 0| 0| 0| 3| 0| 0| 0| 6| 7| 0| 0| 0| 1| 1| 0| 0| 3| 6| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    350MG/KG                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    HIGHMALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Angiectasis                          |                                                                          |             
      Atrophy                              |                                        3                          2      |             
      Hematopoietic Cell Proliferation     |                                                                3         |             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  M  M  +  +  +  +  +  M  +  +  M  M  +  M  +  +  +  +  M  +  M  M|             
      Cyst                                 |                1                                                         |             
      Thymocyte, Necrosis                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  +  M  M  M  M  M  M  M  M  +  M  M  M  M  M  M  +  M  +  +  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                                                2         |             
      Hyperplasia, Basal Cell              |                                                                          |             
      Inflammation, Acute                  |                                  1                                       |             
      Inflammation, Chronic                |                               3                                4         |             
      Inflammation                         |                                           2                              |             
      Face, Inflammation, Acute            |                                                                          |             
      Subcutaneous Tissue, Abscess         |                                              4                           |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Head, Inflammation, Acute            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Thalamus, Mineralization             |    1     1  1  1  1        1           1  1     2  2  1        1  1  1   |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |             2                                                            |             
      Foreign Body                         |             1                                                            |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Chronic                |                            1                    1                        |             
      Leukocytosis                         |                                                                         4|             
      Alveolar Epithelium, Hyperplasia     |          1                                                               |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |          3                                                               |             
      Mediastinum, Foreign Body            |                                                                   3      |             
      Mediastinum, Inflammation, Acute     |                                                                   3      |             
      Pleura, Inflammation, Granulomatous  |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                                                                   2      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  64                                                               
NTP Experiment-Test: 05042-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TRIS (2-CHLOROETHYL) PHOSPHATE                              Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 16:56:49  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 6| 5| 7| 7| 7| 7| 6| 7| 7| 7| 6| 6| 7| 7| 7| 5| 5| 7| 7| 6| 6| 1|             
                             DAY ON TEST   | 3| 3| 6| 0| 8| 3| 3| 3| 3| 7| 3| 3| 3| 6| 2| 3| 3| 3| 7| 1| 3| 3| 7| 6| 3|             
                                           | 0| 0| 6| 4| 8| 0| 0| 0| 0| 3| 0| 0| 0| 6| 7| 0| 0| 0| 1| 1| 0| 0| 3| 6| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    350MG/KG                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    HIGHMALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Subacute                        |                            2                                             |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
      Pinna, Hyperplasia                   |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |       +                          +                       +               |             
      Lens, Cataract                       |                                                          2               |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Hyperplasia                          |                            1                       3           1         |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                     2                                    |             
      Metaplasia, Osseous                  |                                           1                       2      |             
      Nephropathy                          | 2              1        2  4  1        3  2                              |             
      Glomerulus, Dilatation               |                      1                                                   |             
      Pelvis, Inflammation, Acute          |                                                                         4|             
      Proximal Convoluted Renal Tubule,    |                                                                          |             
           Dilatation                      |                                                                          |             
      Renal Tubule, Hyperplasia            |                                                                          |             
      Renal Tubule, Karyomegaly            | 1        1  1  2  1  1  2     1  1  1        1  1  2  1  3  1  1  1  1   |             
      Renal Tubule, Pigmentation           |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                                                                         3|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  65                                                               
NTP Experiment-Test: 05042-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TRIS (2-CHLOROETHYL) PHOSPHATE                              Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 16:56:49  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 2| 7| 7| 6| 6| 4| 7| 7| 7| 7| 0| 7| 7| 7| 7| 1| 7| 7| 6| 6| 5|             
                             DAY ON TEST   | 3| 3| 3| 8| 9| 3| 1| 3| 3| 6| 3| 3| 1| 0| 6| 3| 3| 3| 1| 1| 3| 3| 9| 9| 9|             
                                           | 0| 0| 0| 3| 3| 0| 2| 5| 4| 9| 0| 0| 7| 6| 0| 0| 0| 0| 9| 7| 0| 0| 9| 8| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    350MG/KG                               | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    HIGHMALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Periesophageal Tissue, Foreign Body  |                                                          2               |             
      Periesophageal Tissue, Inflammation, |                                                                          |             
           Acute                           |                                                          3               |             
                                            __________________________________________________________________________|             
   Gallbladder                             | M  M  +  +  A  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  M  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                                                                         1|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | M  M  M  +  A  M  M  M  M  M  +  +  +  M  A  M  +  M  M  +  M  M  +  +  M|             
      Inflammation, Necrotizing            |                                                                   3      |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  A  +  +  M  +  +  +  +  +  M  A  +  +  +  +  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  M  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                         3                                                |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     |                                                       2                  |             
      Clear Cell Focus                     |                                                                2         |             
      Cytomegaly                           |                                                                          |             
      Eosinophilic Focus                   |       3        1              3                    4                     |             
      Mitotic Alteration                   |                                                                          |             
      Mixed Cell Focus                     |                                                                          |             
      Necrosis, Coagulative                |                                                       1           1     3|             
      Vacuolization Cytoplasmic            |             3  2           1                                             |             
                                            __________________________________________________________________________|             
   Mesentery                               |                +                                      +                  |             
      Hemorrhage                           |                                                                          |             
      Fat, Necrosis                        |                3                                                         |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |          1        3                          1  2  2                     |             
      Acinus, Basophilic Focus             |                                                    2                     |             
      Acinus, Hyperplasia                  |                                                 3                        |             
      Acinus, Vacuolization Cytoplasmic    |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                   1        1           1     1  2  1                 2   |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Squamous                |          2                 2     2           1                           |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                                              1                           |             
      Mucosa, Dilatation                   |                                                                   1      |             
                                            __________________________________________________________________________|             
   Tooth                                   | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dysplasia                            | 3  2     3                          3  1                    3  3  3      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  66                                                               
NTP Experiment-Test: 05042-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TRIS (2-CHLOROETHYL) PHOSPHATE                              Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 16:56:49  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 2| 7| 7| 6| 6| 4| 7| 7| 7| 7| 0| 7| 7| 7| 7| 1| 7| 7| 6| 6| 5|             
                             DAY ON TEST   | 3| 3| 3| 8| 9| 3| 1| 3| 3| 6| 3| 3| 1| 0| 6| 3| 3| 3| 1| 1| 3| 3| 9| 9| 9|             
                                           | 0| 0| 0| 3| 3| 0| 2| 5| 4| 9| 0| 0| 7| 6| 0| 0| 0| 0| 9| 7| 0| 0| 9| 8| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    350MG/KG                               | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    HIGHMALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Inflammation, Acute                  |                                  1                                       |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Subacute               |                                     1                                    |             
      Atrium, Thrombosis                   |                                                                          |             
      Myocardium, Degeneration             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              | 1  1  1  2                                                               |             
      Hypertrophy, Focal                   |                                                    3           1         |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  M  +  M  +  M  M  +  +  +  +  M  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  +  +  +  +  +  +  +  +  +  M  M  +  M  +  M  +  +  +  M  +  +  +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ultimobranchial Cyst                 |                                     1                                    |             
      Follicular Cell, Hyperplasia         |                      1                 1     3                          1|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +           +           +                                                |             
      Inflammation, Chronic                |                         3                                                |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Seminiferous Tubule, Atrophy         |                      1                                                   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Renal, Hyperplasia, Lymphoid         |                                     2                                    |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +|             
      Infiltration Cellular, Plasma Cell   |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |    3                                                                     |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  67                                                               
NTP Experiment-Test: 05042-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TRIS (2-CHLOROETHYL) PHOSPHATE                              Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 16:56:49  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 2| 7| 7| 6| 6| 4| 7| 7| 7| 7| 0| 7| 7| 7| 7| 1| 7| 7| 6| 6| 5|             
                             DAY ON TEST   | 3| 3| 3| 8| 9| 3| 1| 3| 3| 6| 3| 3| 1| 0| 6| 3| 3| 3| 1| 1| 3| 3| 9| 9| 9|             
                                           | 0| 0| 0| 3| 3| 0| 2| 5| 4| 9| 0| 0| 7| 6| 0| 0| 0| 0| 9| 7| 0| 0| 9| 8| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    350MG/KG                               | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    HIGHMALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Angiectasis                          |                                                                   3      |             
      Atrophy                              |                         2                                                |             
      Hematopoietic Cell Proliferation     |                                                          3               |             
      Hyperplasia, Lymphoid                |                   2                                                      |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  M  +  M  M  M  +  +  +  +  M  M  +  +  +  +  +  M  +  M  +  +  +|             
      Cyst                                 |                                                 1                        |             
      Thymocyte, Necrosis                  |                                           3                              |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  +  M  M  +  M  M  +  +  +  M  +  M  M  +  M  M  +  M  M  M  +  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Acanthosis                           |                                                                          |             
      Hyperplasia, Basal Cell              |                                                    3                     |             
      Inflammation, Acute                  |                                                    2                     |             
      Inflammation, Chronic                |                                              3        3                  |             
      Inflammation                         |                                                                          |             
      Face, Inflammation, Acute            |                                                                      2   |             
      Subcutaneous Tissue, Abscess         |                                                          4               |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                    1                     |             
      Head, Inflammation, Acute            |    3           2                                                         |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Thalamus, Mineralization             |          2        1  2     1     2  1  1     1  1  1                 1  1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                          2               |             
      Foreign Body                         |             2        1                                                   |             
      Hemorrhage                           |             2                                                            |             
      Inflammation, Chronic                |                                              2                           |             
      Leukocytosis                         |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |       2              2                                                   |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                                                    1                 1   |             
      Mediastinum, Foreign Body            |          1                          1                                    |             
      Mediastinum, Inflammation, Acute     |          3  2     2                 2                                    |             
      Pleura, Inflammation, Granulomatous  |    2                                                                     |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  68                                                               
NTP Experiment-Test: 05042-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TRIS (2-CHLOROETHYL) PHOSPHATE                              Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 16:56:49  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 2| 7| 7| 6| 6| 4| 7| 7| 7| 7| 0| 7| 7| 7| 7| 1| 7| 7| 6| 6| 5|             
                             DAY ON TEST   | 3| 3| 3| 8| 9| 3| 1| 3| 3| 6| 3| 3| 1| 0| 6| 3| 3| 3| 1| 1| 3| 3| 9| 9| 9|             
                                           | 0| 0| 0| 3| 3| 0| 2| 5| 4| 9| 0| 0| 7| 6| 0| 0| 0| 0| 9| 7| 0| 0| 9| 8| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    350MG/KG                               | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    HIGHMALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Subacute                        |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                 +                        |             
      Pinna, Hyperplasia                   |                                                 3                        |             
                                            __________________________________________________________________________|             
   Eye                                     |                            +              +     +                    +   |             
      Lens, Cataract                       |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      Hyperplasia                          |    3  1                                                                  |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Metaplasia, Osseous                  |                                                 1                        |             
      Nephropathy                          | 1                       3  2           1        1           2            |             
      Glomerulus, Dilatation               |                                                                          |             
      Pelvis, Inflammation, Acute          |                                                                          |             
      Proximal Convoluted Renal Tubule,    |                                                                          |             
           Dilatation                      |                   2                                            2         |             
      Renal Tubule, Hyperplasia            |                1                                                         |             
      Renal Tubule, Karyomegaly            | 1  1  1  2  1  1  1  1  1     2  1  2  3     1  1  1        1  1  1  1   |             
      Renal Tubule, Pigmentation           |                                                                         3|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Inflammation, Acute                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  69                                                               
NTP Experiment-Test: 05042-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TRIS (2-CHLOROETHYL) PHOSPHATE                              Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 16:56:49  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 1| 1| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 2| 1| 5| 5| 5| 5|                                            |            |
                                           | 8| 8| 8| 8| 2| 5| 8| 8| 8| 8|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    350MG/KG                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
    HIGHMALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |                                                                          |  50        |
      Periesophageal Tissue, Foreign Body  |                                                                          |      1  2.0|
      Periesophageal Tissue, Inflammation, |                                                                          |            |
           Acute                           |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Gallbladder                             |                                                                          |  34        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |                                                                          |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |                                                                          |  46        |
      Inflammation, Acute                  |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |                                                                          |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |                                                                          |  45        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |                                                                          |  45        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |                                                                          |  11        |
      Inflammation, Necrotizing            |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |                                                                          |  41        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                                                                          |  44        |
      Ulcer                                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Liver                                   |                                                                          |  50        |
      Angiectasis                          |                                                                          |      2  2.0|
      Basophilic Focus                     |                                                                          |      1  2.0|
      Clear Cell Focus                     |                                                                          |      5  2.0|
      Cytomegaly                           |                                                                          |      1  3.0|
      Eosinophilic Focus                   |                                                                          |      8  2.6|
      Mitotic Alteration                   |                                                                          |      1  2.0|
      Mixed Cell Focus                     |                                                                          |      1  3.0|
      Necrosis, Coagulative                |                                                                          |      4  2.3|
      Vacuolization Cytoplasmic            |                                                                          |      4  1.8|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   4        |
      Hemorrhage                           |                                                                          |      1  2.0|
      Fat, Necrosis                        |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                |                                                                          |  49        |
      Acinus, Atrophy                      |                                                                          |      8  1.5|
      Acinus, Basophilic Focus             |                                                                          |      1  2.0|
      Acinus, Hyperplasia                  |                                                                          |      1  3.0|
      Acinus, Vacuolization Cytoplasmic    |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |                                                                          |  49        |
      Inflammation, Chronic                |                                                                          |     13  1.2|
                                            __________________________________________________________________________|____________|
   Stomach                                 |                                                                          |  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |                                                                          |  49        |
      Hyperplasia, Squamous                |                                                                          |      6  1.7|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  70                                                               
NTP Experiment-Test: 05042-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TRIS (2-CHLOROETHYL) PHOSPHATE                              Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 16:56:49  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 1| 1| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 2| 1| 5| 5| 5| 5|                                            |            |
                                           | 8| 8| 8| 8| 2| 5| 8| 8| 8| 8|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    350MG/KG                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
    HIGHMALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |                                                                          |  47        |
      Inflammation, Acute                  |                                                                          |      2  1.0|
      Mucosa, Dilatation                   |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |  49        |
      Dysplasia                            |                                                                          |     18  2.4|
      Inflammation, Acute                  |                                                                          |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |                                                                          |  50        |
      Inflammation, Subacute               |                                                                          |      2  1.0|
      Atrium, Thrombosis                   |                                                                          |      2  2.5|
      Myocardium, Degeneration             |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |                                                                          |  48        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |                                                                          |  48        |
      Atrophy                              |                                                                          |      4  1.3|
      Hypertrophy, Focal                   |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |                                                                          |  43        |
      Hyperplasia                          |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |                                                                          |  49        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |                                                                          |  30        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |                                                                          |  48        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |                                                                          |  49        |
      Ultimobranchial Cyst                 |                                                                          |      1  1.0|
      Follicular Cell, Hyperplasia         |                                                                          |      6  1.3|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              |                                                                          |  47        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |                                                                          |   5        |
      Inflammation, Chronic                |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Prostate                                |                                                                          |  47        |
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |                                                                          |  50        |
                                            __________________________________________________________________________|____________|
   Testes                                  |                                                                          |  50        |
      Seminiferous Tubule, Atrophy         |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  71                                                               
NTP Experiment-Test: 05042-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TRIS (2-CHLOROETHYL) PHOSPHATE                              Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 16:56:49  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 1| 1| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 2| 1| 5| 5| 5| 5|                                            |            |
                                           | 8| 8| 8| 8| 2| 5| 8| 8| 8| 8|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    350MG/KG                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
    HIGHMALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |                                                                          |  49        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |                                                                          |  49        |
      Renal, Hyperplasia, Lymphoid         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  |                                                                          |  44        |
      Infiltration Cellular, Plasma Cell   |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                                                                          |  44        |
      Angiectasis                          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  |                                                                          |  49        |
      Angiectasis                          |                                                                          |      1  3.0|
      Atrophy                              |                                                                          |      3  2.3|
      Hematopoietic Cell Proliferation     |                                                                          |      2  3.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  |                                                                          |  33        |
      Cyst                                 |                                                                          |      2  1.0|
      Thymocyte, Necrosis                  |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |                                                                          |  14        |
                                            __________________________________________________________________________|____________|
   Skin                                    |                                                                          |  49        |
      Acanthosis                           |                                                                          |      1  2.0|
      Hyperplasia, Basal Cell              |                                                                          |      1  3.0|
      Inflammation, Acute                  |                                                                          |      2  1.5|
      Inflammation, Chronic                |                                                                          |      4  3.3|
      Inflammation                         |                                                                          |      1  2.0|
      Face, Inflammation, Acute            |                                                                          |      1  2.0|
      Subcutaneous Tissue, Abscess         |                                                                          |      2  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |                                                                          |  49        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |  50        |
      Inflammation, Chronic                |                                                                          |      1  1.0|
      Head, Inflammation, Acute            |                                                                          |      2  2.5|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |                                                                          |  50        |
      Thalamus, Mineralization             |                                                                          |     26  1.2|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  72                                                               
NTP Experiment-Test: 05042-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TRIS (2-CHLOROETHYL) PHOSPHATE                              Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 16:56:49  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 1| 1| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 2| 1| 5| 5| 5| 5|                                            |            |
                                           | 8| 8| 8| 8| 2| 5| 8| 8| 8| 8|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    350MG/KG                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
    HIGHMALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |                                                                          |  50        |
      Congestion                           |                                                                          |      2  2.0|
      Foreign Body                         |                                                                          |      3  1.3|
      Hemorrhage                           |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                                                          |      3  1.3|
      Leukocytosis                         |                                                                          |      1  4.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      3  1.7|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |                                                                          |      3  1.7|
      Mediastinum, Foreign Body            |                                                                          |      3  1.7|
      Mediastinum, Inflammation, Acute     |                                                                          |      5  2.4|
      Pleura, Inflammation, Granulomatous  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    |                                                                          |  50        |
      Inflammation, Acute                  |                                                                          |      1  2.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Subacute                        |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 |                                                                          |  49        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
      Pinna, Hyperplasia                   |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   7        |
      Lens, Cataract                       |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |  47        |
      Hyperplasia                          |                                                                          |      5  1.8|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |                                                                          |  50        |
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Metaplasia, Osseous                  |                                                                          |      3  1.3|
      Nephropathy                          |                                                                          |     13  1.9|
      Glomerulus, Dilatation               |                                                                          |      1  1.0|
      Pelvis, Inflammation, Acute          |                                                                          |      1  4.0|
      Proximal Convoluted Renal Tubule,    |                                                                          |            |
           Dilatation                      |                                                                          |      2  2.0|
      Renal Tubule, Hyperplasia            |                                                                          |      1  1.0|
      Renal Tubule, Karyomegaly            |                                                                          |     39  1.3|
      Renal Tubule, Pigmentation           |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  73                                                               
NTP Experiment-Test: 05042-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                   TRIS (2-CHLOROETHYL) PHOSPHATE                              Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 16:56:49  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 4| 4| 4| 1| 1| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 5| 5| 5| 2| 1| 5| 5| 5| 5|                                            |            |
                                           | 8| 8| 8| 8| 2| 5| 8| 8| 8| 8|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    350MG/KG                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
    HIGHMALE                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |                                                                          |  49        |
      Inflammation, Acute                  |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  74                                                               
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