National Toxicology Program

National Toxicology Program
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TR 391 Rat Pathology Tables

NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11 
LAB: Microbiological Assoc.                                    DATE: 09/05/94   
EXP: 05042               TRIS 2-CHLOROETHYL PHOSPHATE          TIME: 15:06:05   
TEST: 01              CAGES FROM 0000 TO LAST CAGE             PAGE:   1        
TEST TYPE: CHRONIC          ROUTE: GAVAGE                      NTP C#: 60128    
CONT: N01CP9565001                                             CAS: 115-96-8    
PATHOLOGIST: G. PARKER                                                          
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NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11
LAB: Microbiological Assoc.                                    DATE: 09/05/94  
EXP: 05042               TRIS 2-CHLOROETHYL PHOSPHATE          TIME: 15:06:05  
TEST: 01              CAGES FROM 0000 TO LAST CAGE                             
TEST TYPE: CHRONIC          ROUTE: GAVAGE                      NTP C#: 60128   
CONT: N01CP9565001                                             CAS: 115-96-8   
PATHOLOGIST: G. PARKER                                                         

                           TRIS 2-CHLOROETHYL PHOSPHATE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE RATS
                       FIRST TERMINAL SACRIFICE AT 729 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = CONTROL                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 11     CENSORED DEATHS 13   TERMINAL 36        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      350   403   419   463   518   539   549   595   603   611                 |
 |      641                                                                       |
 |  CENSORED DEATHS                                                               |
 |      399   408   458   458   458   458   458   458   458   458                 |
 |      458   478   505                                                           |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 44MG/KG LOW                              |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 16     CENSORED DEATHS 11   TERMINAL 33        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      441   506   540   562   574   587   603   620   622   634                 |
 |      638   647   660   673   702   714                                         |
 |  CENSORED DEATHS                                                               |
 |      458   458   458   458   458   458   458   458   458   458                 |
 |      463                                                                       |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = 88 MG/KGHIGH                                   |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 24     CENSORED DEATHS 11   TERMINAL 25        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      469   471   528   550   554   575   584   625   630   630                 |
 |      632   648   653   661   674   676   680   683   687   690                 |
 |      695   696   700   710                                                     |
 |  CENSORED DEATHS                                                               |
 |      458   458   458   458   458   458   458   458   458   458                 |
 |      458                                                                       |
 |                                                                                |
 ==================================================================================

                           TRIS 2-CHLOROETHYL PHOSPHATE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE RATS
                       FIRST TERMINAL SACRIFICE AT 729 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   729 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |CONTROL    |   100.0 100.0 100.0  98.3  94.9  92.8  88.5  82.1  77.7  77.7      |
 |           |                                                                    |
 |           |                                                                    |
 |44MG/KG LOW|   100.0 100.0 100.0 100.0 100.0  98.3  94.2  86.0  73.8  67.6      |
 |           |                                                                    |
 |           |                                                                    |
 |88         |   100.0 100.0 100.0 100.0 100.0  95.9  93.9  85.7  71.4  51.0      |
 |MG/KGHIGH  |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                    DOSE                        |
 |                                                                                |
 |                                CONTROL          44MG/KG LOW      88            |
 |                                                                  MG/KGHIGH     |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       77.7%            67.6%            51.0%         |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=0.033          P=0.558          P=0.044       |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       517.4            607.7            629.2         |
 |NATURAL DEATHS (C)      |       (29.0)           (17.9)           (14.5)        |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       630.8            647.1            639.4         |
 |(STANDARD ERROR)        |       (16.7)           (14.2)           (13.9)        |
 |                        |                                                       |
 ==================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                           TRIS 2-CHLOROETHYL PHOSPHATE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE RATS
                       FIRST TERMINAL SACRIFICE AT 729 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = CONTROL                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 17     CENSORED DEATHS 11   TERMINAL 32        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      335   343   403   438   489   582   597   619   633   634                 |
 |      683   695   702   703   711   717   728                                   |
 |  CENSORED DEATHS                                                               |
 |      161   458   458   458   458   458   459   459   459   459                 |
 |      459                                                                       |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 44MG/KG LOW                              |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 14     CENSORED DEATHS 13   TERMINAL 33        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      85    310   561   588   598   617   620   652   671   686                 |
 |      697   704   716   724                                                     |
 |  CENSORED DEATHS                                                               |
 |      154   154   154   459   459   459   459   459   459   459                 |
 |      459   459   459                                                           |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = 88 MG/KG HIGH                                  |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 60     UNCENSORED DEATHS 29     CENSORED DEATHS 14   TERMINAL 17        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      431   469   470   492   519   534   536   547   555   576                 |
 |      581   588   592   596   604   610   610   612   617   634                 |
 |      660   675   687   687   704   704   710   718   724                       |
 |  CENSORED DEATHS                                                               |
 |      154   261   288   394   459   459   459   459   459   459                 |
 |      459   459   459   534                                                     |
 |                                                                                |
 ==================================================================================

                           TRIS 2-CHLOROETHYL PHOSPHATE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE RATS
                       FIRST TERMINAL SACRIFICE AT 729 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   729 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |CONTROL    |   100.0 100.0 100.0  96.6  94.9  93.2  91.1  87.0  80.8  66.3      |
 |           |                                                                    |
 |           |                                                                    |
 |44MG/KG LOW|    98.3  98.3  98.3  96.6  96.6  96.6  96.6  90.1  83.7  70.8      |
 |           |                                                                    |
 |           |                                                                    |
 |88         |   100.0 100.0 100.0 100.0 100.0  93.9  85.4  67.8  54.7  37.2      |
 |MG/KG HIGH |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                    DOSE                        |
 |                                                                                |
 |                                CONTROL          44MG/KG LOW      88            |
 |                                                                  MG/KG HIGH    |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       66.3%            70.8%            37.2%         |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=0.005          P=0.731N         P=0.008       |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       588.9            587.8            601.4         |
 |NATURAL DEATHS (C)      |       (32.9)           (47.7)           (15.1)        |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       634.8            622.3            593.3         |
 |(STANDARD ERROR)        |       (18.0)           (22.1)           (17.6)        |
 |                        |                                                       |
 ==================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                                                    TRIS 2-CHLOROETHYL PHOSPHATE
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        CONTROL          = 1
                                                        44MG/KG LOW      = 2
                                                        88 MG/KGHIGH     = 3

------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  100 + 1                                                      1             2    3
      |                                                        1        1    2          2
      |                                                                           33
      |                                                                 1 1        3    2   3 2
   95 +                                                                   1       1
      |                                                                                     3 23 2
      |                                                                           1      1       22
      |                                                                                  1   1 33
   90 +                                                                                         3 232
      |                                                                                      1 1
      |                                                                                            32   2
      |                                                                                        1    3 1 2 23
P  85 +
E     |                                                                                               1 1
R     |                                                                                                 112 2
C     |
E  80 +                                                                                                  1 321
N     |
T     |                                                                                                     312             1
      |                                                                                                       2  2
S  75 +                                                                                                       33
U     |                                                                                                        3 2 2
R     |
V     |                                                                                                          3 2   2
I  70 +                                                                                                                22
V     |
A     |                                                                                                            33   2   2
L     |
   65 +
      |                                                                                                             33
      |
      |
   60 +
      |                                                                                                              33
      |
      |
   55 +
      |
      |                                                                                                               3 3
      |                                                                                                                 3   3
   50 +
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 9 obs hidden.

                                                    TRIS 2-CHLOROETHYL PHOSPHATE
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        CONTROL          = 1
                                                        44MG/KG LOW      = 2
                                                        88 MG/KG HIGH    = 3

----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  100 + 1             2                                      1              3
      |               2                                   2  11         1   3     3              2
      |                                                                 1    1    33  3          2  2
      |                                                                      1       13    3        2  2
   90 +                                                                              1     3 3      1  1  2
      |                                                                                                1  1
P     |                                                                                      3 3          1 1  2
E     |                                                                                        33              2  2 2
R  80 +                                                                                         3  3        1       1 2
C     |                                                                                            33               1 11
E     |                                                                                             3 3                2 2
N     |                                                                                               33               1122
T  70 +                                                                                                33               112 2
      |                                                                                                 33               11 1
S     |
U     |                                                                                                  33
R  60 +                                                                                                   3 3
V     |                                                                                                     3    3
I     |                                                                                                          3 3
V     |                                                                                                            3 3
A  50 +
L     |                                                                                                              3 3
      |                                                                                                                33
      |                                                                                                                 33
   40 +                                                                                                                  33
      |                                                                                                                   3 3
      |
      |
   30 +
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 14 obs hidden.

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