National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/3816

TR 392 Mouse Pathology Tables


                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                             CHLORAMINE


NTP Experiment-Test: 05089-02                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 09/11/94
Route: DOSED WATER                                                                                                Time: 22:29:05




       Facility:  Southern Research Institute

       Chemical CAS #:   10599903

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05089-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 09/11/94  
Route: DOSED WATER                                                                                                Time: 22:29:05  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        VEHICLE      VEHICLE      0.00500%     0.00500%     0.00700%     0.00700%        
                                                   CONTROL      3 SSAC                     3 SSAC                    3 SSAC         
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          60           10           60           10           60           10           
  Scheduled Sacrifice                                 10           10           10           10            9           10           
  Early Deaths                                                                                                                      
    Natural Death                                      3                         3                         6                        
    Moribund Sacrifice                                13                        14                        14                        
    Accidently Killed                                  1                         1                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                33                        32                        31                        
  Animals Examined Microscopically                    60           10           60            6           60                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (57)         (9)          (49)                      (49)                      
      Cyst                                             3 (5%)                                              1 (2%)                   
      Dilatation                                                                                           1 (2%)                   
      Inflammation, Chronic                            1 (2%)                                                                       
   Intestine Large, Cecum                             (57)         (10)         (47)                      (51)                      
      Edema                                            2 (4%)                                                                       
   Intestine Large, Rectum                            (57)         (8)          (50)                      (50)                      
      Erosion                                                                                              1 (2%)                   
   Intestine Small, Duodenum                          (58)         (9)          (46)                      (51)                      
      Erosion                                                                                              1 (2%)                   
   Intestine Small, Ileum                             (58)         (10)         (50)                      (51)                      
      Artery, Jejunum, Necrosis, Fibrinoid             1 (2%)                                                                       
   Liver                                              (60)         (10)         (50)                      (51)                      
      Angiectasis                                                                                          1 (2%)                   
      Basophilic Focus                                 2 (3%)                    3 (6%)                    2 (4%)                   
      Clear Cell Focus                                 1 (2%)                    2 (4%)                    4 (8%)                   
      Eosinophilic Focus                                                                                   1 (2%)                   
      Hematopoietic Cell Proliferation                 5 (8%)                    4 (8%)                    2 (4%)                   
      Hemorrhage                                       2 (3%)                                                                       
      Hyperplasia, Focal                              12 (20%)                  11 (22%)                  11 (22%)                  
      Hyperplasia, Lymphoid                            6 (10%)                   2 (4%)                    3 (6%)                   
      Infiltration Cellular, Mononuclear Cell          1 (2%)                                                                       
      Inflammation, Acute                                           1 (10%)                                                         
      Inflammation, Chronic                            2 (3%)                    1 (2%)                                             
      Inflammation, Subacute                           5 (8%)                    3 (6%)                    9 (18%)                  
      Mineralization                                   1 (2%)                                                                       
      Mixed Cell Focus                                 1 (2%)                                              1 (2%)                   
      Artery, Necrosis, Fibrinoid                      1 (2%)                                                                       
      Centrilobular, Necrosis                                                    1 (2%)                    1 (2%)                   
      Hepatocyte, Karyomegaly                          1 (2%)                    1 (2%)                                             
      Hepatocyte, Vacuolization Cytoplasmic            3 (5%)                    3 (6%)                    1 (2%)                   
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05089-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 09/11/94  
Route: DOSED WATER                                                                                                Time: 22:29:05  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        VEHICLE      VEHICLE      0.00500%     0.00500%     0.00700%     0.00700%        
                                                   CONTROL      3 SSAC                     3 SSAC                    3 SSAC         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Kupffer Cell, Hyperplasia                        1 (2%)                    1 (2%)                    5 (10%)                  
      Kupffer Cell, Pigmentation                       2 (3%)                                              2 (4%)                   
      Lobules, Necrosis                                6 (10%)                   4 (8%)                    3 (6%)                   
   Mesentery                                          (17)                      (8)                       (10)                      
      Edema                                            1 (6%)                                                                       
      Artery, Necrosis, Fibrinoid                      1 (6%)                                                                       
      Fat, Inflammation, Suppurative                   1 (6%)                                                                       
      Fat, Necrosis                                   14 (82%)                   6 (75%)                   7 (70%)                  
   Pancreas                                           (60)         (10)         (50)                      (50)                      
      Atrophy                                          3 (5%)                    1 (2%)                    1 (2%)                   
      Cyst                                                                                                 1 (2%)                   
      Cytoplasmic Alteration                           2 (3%)                    2 (4%)                    5 (10%)                  
      Focal Cellular Change                            1 (2%)                                                                       
      Hyperplasia, Lymphoid                            8 (13%)                   9 (18%)                   6 (12%)                  
      Inflammation, Subacute                           1 (2%)                                                                       
   Salivary Glands                                    (59)         (10)         (50)                      (51)                      
      Hyperplasia, Lymphoid                           24 (41%)                  15 (30%)                  11 (22%)                  
      Necrosis                                                                   1 (2%)                                             
      Acinus, Hyperplasia, Cystic                      1 (2%)                                                                       
   Stomach, Forestomach                               (60)         (10)         (50)                      (51)                      
      Cyst                                             1 (2%)                                                                       
      Diverticulum                                     1 (2%)                                                                       
      Edema                                            1 (2%)                    1 (2%)                                             
      Fibrosis                                                                   1 (2%)                                             
      Inflammation, Suppurative                        1 (2%)                                                                       
      Ulcer                                            1 (2%)                                                                       
      Mucosa, Hyperplasia                              2 (3%)                    6 (12%)                   1 (2%)                   
   Stomach, Glandular                                 (60)         (10)         (50)                      (51)                      
      Cyst                                            10 (17%)                   8 (16%)                  13 (25%)                  
      Edema                                            2 (3%)                    1 (2%)                                             
      Erosion                                          1 (2%)                                              2 (4%)                   
      Inflammation, Subacute                           3 (5%)                    1 (2%)                                             
      Metaplasia, Squamous                             1 (2%)                                                                       
      Mineralization                                   1 (2%)                                                                       
      Ulcer                                                                                                1 (2%)                   
      Mucosa, Hyperplasia                                                        1 (2%)                    1 (2%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (2)                                                 (1)                       
      Necrosis, Fibrinoid                              1 (50%)                                                                      
      Thrombosis                                       1 (50%)                                                                      
   Heart                                              (60)         (10)         (50)                      (51)                      
      Myocardium, Inflammation, Subacute               1 (2%)                                                                       
      Myocardium, Mineralization                       1 (2%)                                              1 (2%)                   
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05089-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 09/11/94  
Route: DOSED WATER                                                                                                Time: 22:29:05  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        VEHICLE      VEHICLE      0.00500%     0.00500%     0.00700%     0.00700%        
                                                   CONTROL      3 SSAC                     3 SSAC                    3 SSAC         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (60)         (10)         (50)                      (51)                      
      Accessory Adrenal Cortical Nodule               11 (18%)      1 (10%)     10 (20%)                  18 (35%)                  
      Basophilic Focus                                 3 (5%)                                                                       
      Clear Cell Focus                                 1 (2%)                                              2 (4%)                   
      Cyst                                                                       2 (4%)                                             
      Hyperplasia, Focal                               3 (5%)                                              4 (8%)                   
      Capsule, Hyperplasia                             3 (5%)                                              3 (6%)                   
      X-Zone, Degeneration, Fatty                                                2 (4%)                    1 (2%)                   
      Zona Reticularis, Proliferation                                            1 (2%)                                             
   Adrenal Gland, Medulla                             (60)         (9)          (50)                      (51)                      
      Hyperplasia                                      1 (2%)                    1 (2%)                                             
   Islets, Pancreatic                                 (60)         (10)         (50)                      (50)                      
      Hyperplasia                                      3 (5%)                    8 (16%)                   5 (10%)                  
      Hyperplasia, Lymphoid                            1 (2%)                                                                       
   Parathyroid Gland                                  (57)         (10)         (49)                      (50)                      
      Cyst                                                                       1 (2%)                                             
      Ectopic Thymus                                   1 (2%)                                                                       
      Hyperplasia                                      1 (2%)                                                                       
   Pituitary Gland                                    (58)         (9)          (50)                      (50)                      
      Pars Distalis, Angiectasis                       3 (5%)                    3 (6%)                    2 (4%)                   
      Pars Distalis, Cyst                                                        1 (2%)                                             
      Pars Distalis, Hyperplasia                       9 (16%)                   6 (12%)                   7 (14%)                  
      Pars Distalis, Hyperplasia, Focal                                          1 (2%)                                             
   Thyroid Gland                                      (60)         (10)         (49)                      (51)                      
      Degeneration, Cystic                            26 (43%)                  26 (53%)                  26 (51%)                  
      Hyperplasia, Lymphoid                                                      3 (6%)                    3 (6%)                   
      Inflammation, Subacute                           2 (3%)                    3 (6%)                    2 (4%)                   
      Follicle, Cyst                                   3 (5%)                                              1 (2%)                   
      Follicular Cell, Hyperplasia                    12 (20%)                  10 (20%)                  17 (33%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                                               (1)                                                 
      Ectasia                                                                    1 (100%)                                           
   Ovary                                              (56)         (10)         (46)                      (46)                      
      Angiectasis                                     11 (20%)                  13 (28%)                  15 (33%)                  
      Cyst                                            13 (23%)                  11 (24%)                  14 (30%)                  
      Hemorrhage                                                    1 (10%)                                                         
      Hyperplasia                                      1 (2%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05089-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 09/11/94  
Route: DOSED WATER                                                                                                Time: 22:29:05  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        VEHICLE      VEHICLE      0.00500%     0.00500%     0.00700%     0.00700%        
                                                   CONTROL      3 SSAC                     3 SSAC                    3 SSAC         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Artery, Necrosis, Fibrinoid                      1 (2%)                                                                       
   Uterus                                             (60)         (10)         (60)         (2)          (59)                      
      Angiectasis                                      5 (8%)                    4 (7%)                    4 (7%)                   
      Hydrometra                                      20 (33%)                  14 (23%)                  19 (32%)                  
      Hyperplasia, Cystic                             59 (98%)                  59 (98%)                  58 (98%)                  
      Hyperplasia, Histiocytic                                                                             1 (2%)                   
      Hyperplasia, Lymphoid                            1 (2%)                    2 (3%)                    3 (5%)                   
      Inflammation, Suppurative                        5 (8%)                    2 (3%)                                             
      Metaplasia, Squamous                             1 (2%)                    2 (3%)                    1 (2%)                   
      Endometrium, Cyst                                                                       2 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (60)         (10)         (50)                      (51)                      
      Hypercellularity                                 7 (12%)                   6 (12%)                   5 (10%)                  
   Lymph Node                                         (60)         (10)         (50)                      (51)                      
      Artery, Necrosis, Fibrinoid                      1 (2%)                                                                       
      Iliac, Angiectasis                               2 (3%)                                                                       
      Iliac, Hyperplasia, Lymphoid                                               1 (2%)                                             
      Iliac, Hyperplasia, Plasma Cell                  2 (3%)                                                                       
      Mediastinal, Hyperplasia, Lymphoid                                         1 (2%)                                             
      Renal, Hyperplasia, Plasma Cell                  1 (2%)                                                                       
   Lymph Node, Mandibular                             (56)         (10)         (49)                      (49)                      
      Hyperplasia, Lymphoid                            5 (9%)                    4 (8%)                    4 (8%)                   
      Hyperplasia, Plasma Cell                                                   1 (2%)                    1 (2%)                   
   Lymph Node, Mesenteric                             (59)         (9)          (50)                      (47)                      
      Depletion Cellular                                                         1 (2%)                                             
      Hematopoietic Cell Proliferation                 2 (3%)                    1 (2%)                    1 (2%)                   
      Hemorrhage                                       2 (3%)                    3 (6%)                    4 (9%)                   
      Hyperplasia, Lymphoid                            4 (7%)                    3 (6%)                    2 (4%)                   
      Hyperplasia, Plasma Cell                         2 (3%)                                              1 (2%)                   
      Lymphatic, Dilatation                                                                                2 (4%)                   
   Spleen                                             (59)         (10)         (50)                      (51)                      
      Angiectasis                                                                1 (2%)                                             
      Congestion                                                                                           1 (2%)                   
      Hematopoietic Cell Proliferation                21 (36%)                  19 (38%)                  17 (33%)                  
      Hemorrhage                                       1 (2%)                                              1 (2%)                   
      Necrosis                                         1 (2%)                                                                       
      Pigmentation, Hemosiderin                        5 (8%)                    4 (8%)                    3 (6%)                   
      Lymphoid Follicle, Atrophy                       1 (2%)                    2 (4%)                    1 (2%)                   
      Lymphoid Follicle, Hyperplasia                   4 (7%)                    7 (14%)                   6 (12%)                  
      Red Pulp, Atrophy                                                          1 (2%)                                             
      Red Pulp, Hyperplasia                            3 (5%)                    2 (4%)                    2 (4%)                   
   Thymus                                             (58)         (10)         (47)                      (49)                      
      Angiectasis                                      3 (5%)                    1 (2%)                    1 (2%)                   
      Cyst                                             9 (16%)                  10 (21%)                   5 (10%)                  
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05089-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 09/11/94  
Route: DOSED WATER                                                                                                Time: 22:29:05  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        VEHICLE      VEHICLE      0.00500%     0.00500%     0.00700%     0.00700%        
                                                   CONTROL      3 SSAC                     3 SSAC                    3 SSAC         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Depletion Cellular                               3 (5%)                    6 (13%)                  10 (20%)                  
      Ectopic Parathyroid Gland                        1 (2%)                    1 (2%)                                             
      Hyperplasia, Lymphoid                            3 (5%)                    2 (4%)                                             
      Artery, Necrosis, Fibrinoid                      1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (59)         (10)         (50)                      (50)                      
      Hyperplasia, Cystic                                                                                  3 (6%)                   
      Hyperplasia, Lobular                                                       1 (2%)                                             
   Skin                                               (60)         (10)         (50)                      (51)                      
      Acanthosis                                       1 (2%)                    2 (4%)                    3 (6%)                   
      Exudate                                                                                              1 (2%)                   
      Inflammation, Chronic                            1 (2%)                                              4 (8%)                   
      Inflammation, Chronic, Focal                                               1 (2%)                                             
      Ulcer                                                                      1 (2%)                    1 (2%)                   
      Subcutaneous Tissue, Edema                       2 (3%)                                              3 (6%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (60)         (10)         (50)                      (51)                      
      Fibrous Osteodystrophy                           1 (2%)                                                                       
      Hyperostosis                                     6 (10%)                   9 (18%)                   7 (14%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (59)         (10)         (50)                      (51)                      
      Compression                                                                1 (2%)                                             
      Cyst                                             2 (3%)                                                                       
      Inflammation, Chronic                                                                                1 (2%)                   
      Necrosis                                                                   1 (2%)                                             
      Parenchyma, Vacuolization Cytoplasmic,                                                                                        
          Diffuse                                                                1 (2%)                                             
      Thalamus, Mineralization                        48 (81%)                  27 (54%)                  45 (88%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (10)         (50)                      (51)                      
      Congestion                                       2 (3%)                                              3 (6%)                   
      Edema                                            1 (2%)                                                                       
      Hemorrhage                                       2 (3%)       2 (20%)      3 (6%)                    4 (8%)                   
      Hyperplasia, Lymphoid                           10 (17%)                   9 (18%)                   9 (18%)                  
      Infiltration Cellular, Histiocyte                3 (5%)                    3 (6%)                    7 (14%)                  
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05089-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 09/11/94  
Route: DOSED WATER                                                                                                Time: 22:29:05  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        VEHICLE      VEHICLE      0.00500%     0.00500%     0.00700%     0.00700%        
                                                   CONTROL      3 SSAC                     3 SSAC                    3 SSAC         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Inflammation, Chronic                            1 (2%)       1 (10%)                                                         
      Leukocytosis                                                               1 (2%)                                             
      Thrombosis                                                                 2 (4%)                    1 (2%)                   
      Alveolar Epithelium, Hyperplasia                 1 (2%)                    2 (4%)                    1 (2%)                   
   Nose                                               (60)         (10)         (50)                      (51)                      
      Exudate                                          3 (5%)                    2 (4%)                    5 (10%)                  
      Glands, Hyperplasia, Cystic                      5 (8%)                    3 (6%)                    7 (14%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                                          (1)                                                 
      Cornea, Inflammation, Chronic                                              1 (100%)                                           
   Harderian Gland                                    (1)                       (1)                       (3)                       
      Hyperplasia, Focal                                                                                   2 (67%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (10)         (53)         (4)          (57)                      
      Casts Protein                                   14 (23%)                  10 (19%)                  10 (18%)                  
      Cyst                                                                       1 (2%)                    6 (11%)                  
      Glomerulosclerosis                               2 (3%)                    1 (2%)                    3 (5%)                   
      Hemorrhage                                                                 1 (2%)                    1 (2%)                   
      Hydronephrosis                                   3 (5%)                    2 (4%)                    2 (4%)                   
      Hyperplasia, Lymphoid                           27 (45%)                  14 (26%)                  15 (26%)                  
      Inflammation, Suppurative                        1 (2%)                                                                       
      Metaplasia, Osseous                              1 (2%)                    1 (2%)                    2 (4%)                   
      Mineralization                                  25 (42%)                   9 (17%)                   6 (11%)                  
      Interstitium, Pigmentation                                                 1 (2%)                    1 (2%)                   
      Papilla, Necrosis                                1 (2%)                                                                       
      Renal Tubule, Atrophy                            4 (7%)                    7 (13%)                   4 (7%)                   
      Renal Tubule, Cytoplasmic Alteration                                                                 1 (2%)                   
      Renal Tubule, Dilatation                         5 (8%)                    4 (8%)                    3 (5%)                   
      Renal Tubule, Necrosis                           1 (2%)                                                                       
      Renal Tubule, Pigmentation                                                 1 (2%)                                             
      Renal Tubule, Regeneration                      41 (68%)      2 (20%)     34 (64%)      4 (100%)    40 (70%)                  
      Transitional Epithelium, Hyperplasia             2 (3%)                    1 (2%)                                             
   Ureter                                             (1)                                                                           
      Dilatation                                       1 (100%)                                                                     
      Inflammation, Suppurative                        1 (100%)                                                                     
   Urinary Bladder                                    (59)         (10)         (49)                      (50)                      
      Dilatation                                       1 (2%)                                              1 (2%)                   
      Edema                                                                      1 (2%)                    1 (2%)                   
      Hyperplasia, Lymphoid                           26 (44%)                  21 (43%)                  18 (36%)                  
      Inflammation, Chronic                                                                                1 (2%)                   
      Inflammation, Subacute                           3 (5%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 05089-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 09/11/94  
Route: DOSED WATER                                                                                                Time: 22:29:05  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        VEHICLE      VEHICLE      0.00500%     0.00500%     0.00700%     0.00700%        
                                                   CONTROL      3 SSAC                     3 SSAC                    3 SSAC         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Mucosa, Hyperplasia                              2 (3%)                                                                       
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 05089-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 09/11/94  
Route: DOSED WATER                                                                                                Time: 22:29:05  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        0.0100%      0.0100%      0.0140%      0.0140%      0.0200%      0.0200%         
                                                                3 SSAC                    3 SSAC                    3 SSAC          
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          60           10           60           10           60           10           
  Scheduled Sacrifice                                 10           10           10           10           10           10           
  Early Deaths                                                                                                                      
    Natural Death                                      6                         3                         3                        
    Moribund Sacrifice                                 9                        19                         5                        
  Survivors                                                                                                                         
    Terminal Sacrifice                                35                        27                        42                        
    Natural Death                                                                1                                                  
  Animals Examined Microscopically                    60            4           60            1           60           10           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (48)                      (48)                      (59)         (9)          
      Cyst                                                                       1 (2%)                                             
      Dilatation                                       1 (2%)                    1 (2%)                                             
      Hyperplasia, Lymphoid                                                      1 (2%)                                             
      Necrosis                                                                   1 (2%)                                             
   Intestine Large, Cecum                             (50)                      (50)                      (59)         (10)         
      Edema                                                                      3 (6%)                    1 (2%)                   
   Intestine Small, Duodenum                          (48)                      (50)                      (59)         (10)         
      Ulcer                                                                      1 (2%)                                             
   Liver                                              (50)                      (50)                      (60)         (10)         
      Angiectasis                                      1 (2%)                                                                       
      Basophilic Focus                                 7 (14%)                   2 (4%)                                             
      Clear Cell Focus                                 1 (2%)                    4 (8%)                                             
      Hematopoietic Cell Proliferation                                           5 (10%)                   2 (3%)                   
      Hemorrhage                                       1 (2%)                    1 (2%)                                             
      Hyperplasia, Focal                               9 (18%)                   4 (8%)                    9 (15%)                  
      Hyperplasia, Lymphoid                            4 (8%)                                              9 (15%)                  
      Inflammation, Chronic                            1 (2%)                                              3 (5%)       4 (40%)     
      Inflammation, Subacute                           7 (14%)                   4 (8%)                    4 (7%)                   
      Mixed Cell Focus                                                                                     1 (2%)                   
      Centrilobular, Necrosis                                                    1 (2%)                                             
      Hepatocyte, Vacuolization Cytoplasmic            1 (2%)                    6 (12%)                                            
      Kupffer Cell, Hyperplasia                        1 (2%)                    3 (6%)                    2 (3%)                   
      Kupffer Cell, Pigmentation                                                                           1 (2%)                   
      Lobules, Necrosis                               10 (20%)                   8 (16%)                   5 (8%)                   
   Mesentery                                          (8)                       (12)                      (2)                       
      Accessory Spleen                                                                                     1 (50%)                  
      Fat, Necrosis                                    6 (75%)                   7 (58%)                   1 (50%)                  
   Pancreas                                           (49)                      (49)                      (60)         (10)         
      Atrophy                                          2 (4%)                    1 (2%)                    2 (3%)                   
      Cyst                                             1 (2%)                    1 (2%)                    1 (2%)                   
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    9                                                              
NTP Experiment-Test: 05089-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 09/11/94  
Route: DOSED WATER                                                                                                Time: 22:29:05  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        0.0100%      0.0100%      0.0140%      0.0140%      0.0200%      0.0200%         
                                                                3 SSAC                    3 SSAC                    3 SSAC          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Cytoplasmic Alteration                           5 (10%)                   7 (14%)                   1 (2%)                   
      Focal Cellular Change                            1 (2%)                    1 (2%)                                             
      Hyperplasia, Lymphoid                            5 (10%)                   4 (8%)                    2 (3%)       1 (10%)     
      Inflammation, Chronic Active                                               1 (2%)                                             
   Salivary Glands                                    (50)                      (50)                      (60)         (10)         
      Hyperplasia, Lymphoid                           22 (44%)                   9 (18%)                  19 (32%)                  
   Stomach, Forestomach                               (50)                      (50)                      (59)         (10)         
      Diverticulum                                                                                         2 (3%)                   
      Edema                                                                      1 (2%)                    1 (2%)                   
      Inflammation, Subacute                           1 (2%)                                                                       
      Inflammation, Suppurative                        1 (2%)                    2 (4%)                                             
      Ulcer                                                                      1 (2%)                                             
      Mucosa, Hyperplasia                              2 (4%)                    6 (12%)                                            
   Stomach, Glandular                                 (50)                      (50)                      (59)         (10)         
      Cyst                                             7 (14%)                   9 (18%)                  10 (17%)                  
      Edema                                            1 (2%)                    1 (2%)                                             
      Erosion                                          1 (2%)                    1 (2%)                                             
      Inflammation, Subacute                                                     1 (2%)                    3 (5%)                   
      Metaplasia, Squamous                                                       2 (4%)                    1 (2%)                   
      Mucosa, Hyperplasia                                                                                  1 (2%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                                                                           (2)                       
      Hypertrophy                                                                                          2 (100%)                 
      Inflammation, Chronic                                                                                1 (50%)                  
   Heart                                              (50)                      (50)                      (60)         (10)         
      Myocardium, Fibrosis                                                       2 (4%)                                             
      Myocardium, Inflammation, Chronic                1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)                      (50)                      (60)         (10)         
      Accessory Adrenal Cortical Nodule                9 (18%)                   8 (16%)                  17 (28%)      1 (10%)     
      Basophilic Focus                                 1 (2%)                                              1 (2%)                   
      Clear Cell Focus                                                                                     1 (2%)                   
      Cyst                                             1 (2%)                    1 (2%)                    2 (3%)                   
      Developmental Malformation                                                 1 (2%)                                             
      Hematopoietic Cell Proliferation                                           2 (4%)                                             
      Hyperplasia, Focal                               5 (10%)                   5 (10%)                   1 (2%)                   
      Capsule, Hyperplasia                             1 (2%)                                              2 (3%)                   
      X-Zone, Degeneration, Fatty                      1 (2%)                                                                       
   Adrenal Gland, Medulla                             (50)                      (50)                      (60)         (9)          
      Hyperplasia                                      2 (4%)                    3 (6%)                                             
   Islets, Pancreatic                                 (48)                      (49)                      (60)         (10)         
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   10                                                              
NTP Experiment-Test: 05089-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 09/11/94  
Route: DOSED WATER                                                                                                Time: 22:29:05  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        0.0100%      0.0100%      0.0140%      0.0140%      0.0200%      0.0200%         
                                                                3 SSAC                    3 SSAC                    3 SSAC          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Cyst                                             1 (2%)                                                                       
      Hyperplasia                                      6 (13%)                   8 (16%)                   6 (10%)                  
      Hyperplasia, Lymphoid                            1 (2%)                                                                       
   Parathyroid Gland                                  (49)                      (48)                      (58)         (9)          
      Cyst                                             1 (2%)                    4 (8%)                                             
      Ectopic Thymus                                   2 (4%)                                              1 (2%)                   
      Hyperplasia                                      1 (2%)                                                                       
      Pigmentation                                                                                         1 (2%)                   
   Pituitary Gland                                    (47)                      (48)                      (60)         (8)          
      Pars Distalis, Angiectasis                       4 (9%)                    2 (4%)                    1 (2%)                   
      Pars Distalis, Cyst                              2 (4%)                                              1 (2%)                   
      Pars Distalis, Hyperplasia                       7 (15%)                   9 (19%)                   7 (12%)                  
   Thyroid Gland                                      (50)                      (50)                      (59)         (10)         
      Degeneration, Cystic                            23 (46%)                  25 (50%)                  21 (36%)                  
      Ectopic Thymus                                   1 (2%)                                                                       
      Inflammation, Subacute                           3 (6%)                    1 (2%)                    3 (5%)                   
      Follicle, Cyst                                   1 (2%)                    3 (6%)                    3 (5%)                   
      Follicular Cell, Hyperplasia                    10 (20%)                   8 (16%)                   9 (15%)                  
      Follicular Cell, Hyperplasia, Diffuse            1 (2%)                                                                       
      Follicular Cell, Hyperplasia, Focal              1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                                               (2)                                                 
      Ectasia                                                                    2 (100%)                                           
   Ovary                                              (48)                      (48)                      (57)         (10)         
      Angiectasis                                     10 (21%)                  10 (21%)                  15 (26%)                  
      Cyst                                            17 (35%)                  16 (33%)                  20 (35%)                  
      Hemorrhage                                                                 1 (2%)                                             
      Interstitial Cell, Hyperplasia                   1 (2%)                    1 (2%)                                             
   Uterus                                             (59)         (4)          (60)         (1)          (60)         (10)         
      Angiectasis                                      5 (8%)                    7 (12%)                   4 (7%)                   
      Granuloma                                        1 (2%)                                                                       
      Hemorrhage                                                                                           1 (2%)                   
      Hydrometra                                      18 (31%)                  22 (37%)                  14 (23%)                  
      Hyperplasia, Cystic                             54 (92%)                  56 (93%)                  56 (93%)                  
      Hyperplasia, Lymphoid                            2 (3%)                    2 (3%)                                             
      Inflammation, Suppurative                        3 (5%)                    4 (7%)                    4 (7%)       1 (10%)     
      Metaplasia, Squamous                             1 (2%)                    3 (5%)                    3 (5%)                   
      Endometrium, Cyst                                             4 (100%)                  1 (100%)                  3 (30%)     
      Myometrium, Fibrosis                                                       1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   11                                                              
NTP Experiment-Test: 05089-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 09/11/94  
Route: DOSED WATER                                                                                                Time: 22:29:05  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        0.0100%      0.0100%      0.0140%      0.0140%      0.0200%      0.0200%         
                                                                3 SSAC                    3 SSAC                    3 SSAC          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)                      (50)                      (60)         (10)         
      Hypercellularity                                 2 (4%)                    9 (18%)                   4 (7%)                   
   Lymph Node                                         (50)                      (50)                      (60)         (10)         
      Iliac, Hematopoietic Cell Proliferation                                    1 (2%)                                             
      Iliac, Hemorrhage                                                          1 (2%)                                             
      Iliac, Hyperplasia, Lymphoid                                                                         1 (2%)                   
      Iliac, Hyperplasia, Plasma Cell                                            1 (2%)                                             
      Iliac, Lymphatic, Dilatation                                               1 (2%)                                             
      Mediastinal, Hematopoietic Cell Proliferation                              1 (2%)                                             
      Renal, Hyperplasia, Lymphoid                                                                         2 (3%)                   
   Lymph Node, Mandibular                             (47)                      (50)                      (60)         (10)         
      Hematopoietic Cell Proliferation                                           1 (2%)                                             
      Hemorrhage                                       1 (2%)                                                                       
      Hyperplasia, Lymphoid                            1 (2%)                    2 (4%)                    1 (2%)                   
      Hyperplasia, Plasma Cell                                                   1 (2%)                    1 (2%)                   
   Lymph Node, Mesenteric                             (48)                      (48)                      (56)         (10)         
      Hematopoietic Cell Proliferation                                           3 (6%)                                             
      Hemorrhage                                       1 (2%)                    5 (10%)                   1 (2%)                   
      Hyperplasia, Lymphoid                                                      1 (2%)                                             
      Hyperplasia, Plasma Cell                                                                             1 (2%)                   
   Spleen                                             (50)                      (49)                      (60)         (10)         
      Congestion                                                                                           1 (2%)                   
      Hematopoietic Cell Proliferation                13 (26%)                  19 (39%)                  18 (30%)                  
      Hemorrhage                                       1 (2%)                                                                       
      Pigmentation, Hemosiderin                        1 (2%)                                              1 (2%)                   
      Lymphoid Follicle, Atrophy                                                 1 (2%)                                             
      Lymphoid Follicle, Hyperplasia                   5 (10%)                   6 (12%)                   9 (15%)                  
      Red Pulp, Atrophy                                                                                    1 (2%)                   
      Red Pulp, Hyperplasia                            3 (6%)                    2 (4%)                    4 (7%)                   
   Thymus                                             (47)                      (46)                      (51)         (10)         
      Angiectasis                                      2 (4%)                    5 (11%)                   2 (4%)                   
      Cyst                                             4 (9%)                    6 (13%)                   5 (10%)                  
      Depletion Cellular                               3 (6%)                    9 (20%)                   2 (4%)                   
      Ectopic Parathyroid Gland                        1 (2%)                                                                       
      Hyperplasia, Lymphoid                            1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (49)                      (50)                      (60)         (10)         
      Hyperplasia, Cystic                              2 (4%)                    4 (8%)                    2 (3%)                   
      Hyperplasia, Lobular                                                                                 1 (2%)                   
   Skin                                               (49)                      (50)                      (58)         (10)         
      Acanthosis                                       2 (4%)                                              2 (3%)                   
      Inflammation, Chronic                            1 (2%)                                              1 (2%)                   
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   12                                                              
NTP Experiment-Test: 05089-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 09/11/94  
Route: DOSED WATER                                                                                                Time: 22:29:05  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        0.0100%      0.0100%      0.0140%      0.0140%      0.0200%      0.0200%         
                                                                3 SSAC                    3 SSAC                    3 SSAC          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - CONT                                                                                                         
      Subcutaneous Tissue, Edema                                                                           1 (2%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)                      (50)                      (60)         (10)         
      Hyperostosis                                     7 (14%)                   6 (12%)                   7 (12%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)                      (50)                      (60)         (10)         
      Compression                                      1 (2%)                                              1 (2%)                   
      Cyst                                                                       1 (2%)                                             
      Hemorrhage                                                                 1 (2%)                                             
      Hydrocephalus                                    1 (2%)                    1 (2%)                                             
      Inflammation, Chronic                                                      1 (2%)                    1 (2%)                   
      Necrosis                                                                   2 (4%)                                             
      Thalamus, Mineralization                        33 (66%)                  44 (88%)                  39 (65%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)                      (50)                      (60)         (10)         
      Congestion                                       5 (10%)                   2 (4%)                    2 (3%)                   
      Fibrosis                                                                   2 (4%)                                             
      Hemorrhage                                       2 (4%)                    2 (4%)                    2 (3%)                   
      Hyperplasia, Lymphoid                           12 (24%)                  15 (30%)                  13 (22%)                  
      Infiltration Cellular, Histiocyte                2 (4%)                    5 (10%)                   9 (15%)                  
      Inflammation, Chronic                                                                                1 (2%)                   
      Leukocytosis                                     1 (2%)                    1 (2%)                    1 (2%)                   
      Thrombosis                                                                 1 (2%)                                             
      Alveolar Epithelium, Hyperplasia                                           1 (2%)                    1 (2%)                   
   Nose                                               (50)                      (50)                      (60)         (10)         
      Exudate                                                                    3 (6%)                    2 (3%)                   
      Glands, Hyperplasia, Cystic                      1 (2%)                    6 (12%)                   4 (7%)                   
   Trachea                                            (50)                      (49)                      (59)         (10)         
      Inflammation, Suppurative                                                  1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                                          (1)                                                 
      Cataract                                                                   1 (100%)                                           
      Cornea, Inflammation, Chronic                                              1 (100%)                                           
   Harderian Gland                                    (1)                       (4)                       (6)                       
      Cyst                                                                       1 (25%)                   1 (17%)                  
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   13                                                              
NTP Experiment-Test: 05089-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 09/11/94  
Route: DOSED WATER                                                                                                Time: 22:29:05  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        0.0100%      0.0100%      0.0140%      0.0140%      0.0200%      0.0200%         
                                                                3 SSAC                    3 SSAC                    3 SSAC          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
SPECIAL SENSES SYSTEM - CONT                                                                                                        
      Hyperplasia, Focal                                                         1 (25%)                   1 (17%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (57)                      (56)                      (60)         (10)         
      Amyloid Deposition                                                                                   1 (2%)                   
      Casts Protein                                    6 (11%)                   8 (14%)                   7 (12%)                  
      Cyst                                             1 (2%)                                              2 (3%)                   
      Glomerulosclerosis                                                         2 (4%)                                             
      Hemorrhage                                       1 (2%)                    1 (2%)                    2 (3%)                   
      Hydronephrosis                                                             1 (2%)                                             
      Hyperplasia, Lymphoid                           15 (26%)                  15 (27%)                  23 (38%)                  
      Metaplasia, Osseous                              4 (7%)                    2 (4%)                    1 (2%)                   
      Mineralization                                   8 (14%)                  13 (23%)                  13 (22%)                  
      Thrombosis                                       1 (2%)                                                                       
      Interstitium, Pigmentation                       1 (2%)                    2 (4%)                                             
      Renal Tubule, Atrophy                            6 (11%)                   7 (13%)                   8 (13%)                  
      Renal Tubule, Casts Protein                      1 (2%)                                                                       
      Renal Tubule, Cytoplasmic Alteration                                       1 (2%)                                             
      Renal Tubule, Dilatation                         6 (11%)                   4 (7%)                                             
      Renal Tubule, Necrosis                           1 (2%)                    2 (4%)                                             
      Renal Tubule, Pigmentation                       1 (2%)                    1 (2%)                    1 (2%)                   
      Renal Tubule, Regeneration                      42 (74%)                  38 (68%)                  31 (52%)      3 (30%)     
      Transitional Epithelium, Hyperplasia             1 (2%)                    1 (2%)                                             
   Urinary Bladder                                    (49)                      (49)                      (60)         (10)         
      Angiectasis                                      1 (2%)                                                                       
      Edema                                                                      1 (2%)                                             
      Hyperplasia, Lymphoid                           27 (55%)                  23 (47%)                  35 (58%)                  
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   14                                                              
NTP Experiment-Test: 05089-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 09/11/94  
Route: DOSED WATER                                                                                                Time: 22:29:05  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        0.0275%      0.0275%                                                             
                                                                3 SSAC                                                              
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          60           10                                                               
  Scheduled Sacrifice                                 10           10                                                               
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                12                                                                            
    Natural Death                                      3                                                                            
  Survivors                                                                                                                         
    Terminal Sacrifice                                35                                                                            
  Animals Examined Microscopically                    60           10                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (60)         (10)                                                             
      Cyst                                             1 (2%)                                                                       
   Liver                                              (60)         (10)                                                             
      Angiectasis                                      1 (2%)                                                                       
      Basophilic Focus                                 6 (10%)                                                                      
      Clear Cell Focus                                 4 (7%)                                                                       
      Hematopoietic Cell Proliferation                 1 (2%)                                                                       
      Hemorrhage                                       1 (2%)                                                                       
      Hyperplasia, Focal                              12 (20%)                                                                      
      Hyperplasia, Lymphoid                            7 (12%)                                                                      
      Inflammation, Chronic                            3 (5%)       2 (20%)                                                         
      Inflammation, Subacute                           5 (8%)                                                                       
      Mineralization                                   1 (2%)                                                                       
      Mixed Cell Focus                                 1 (2%)                                                                       
      Hepatocyte, Cytomegaly                           1 (2%)                                                                       
      Hepatocyte, Karyomegaly                          2 (3%)                                                                       
      Hepatocyte, Nuclear Alteration                   1 (2%)                                                                       
      Hepatocyte, Vacuolization Cytoplasmic            3 (5%)                                                                       
      Kupffer Cell, Hyperplasia                        3 (5%)                                                                       
      Kupffer Cell, Pigmentation                       1 (2%)                                                                       
      Lobules, Necrosis                                8 (13%)      1 (10%)                                                         
   Mesentery                                          (8)                                                                           
      Fat, Necrosis                                    6 (75%)                                                                      
   Pancreas                                           (60)         (10)                                                             
      Atrophy                                          3 (5%)                                                                       
      Cytoplasmic Alteration                           3 (5%)                                                                       
      Focal Cellular Change                            1 (2%)                                                                       
      Hyperplasia, Lymphoid                            4 (7%)       1 (10%)                                                         
   Salivary Glands                                    (60)         (10)                                                             
      Hyperplasia, Lymphoid                           20 (33%)                                                                      
   Stomach, Forestomach                               (60)         (10)                                                             
      Cyst                                             1 (2%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   15                                                              
NTP Experiment-Test: 05089-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 09/11/94  
Route: DOSED WATER                                                                                                Time: 22:29:05  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        0.0275%      0.0275%                                                             
                                                                3 SSAC                                                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Diverticulum                                     1 (2%)                                                                       
      Erosion                                          1 (2%)                                                                       
      Inflammation, Suppurative                        1 (2%)                                                                       
      Mucosa, Hyperplasia                              2 (3%)                                                                       
   Stomach, Glandular                                 (60)         (10)                                                             
      Cyst                                             5 (8%)                                                                       
      Erosion                                          2 (3%)                                                                       
      Inflammation, Subacute                           2 (3%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (1)                                                                           
      Hypertrophy                                      1 (100%)                                                                     
   Heart                                              (60)         (10)                                                             
      Myocardium, Mineralization                       1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (60)         (9)                                                              
      Accessory Adrenal Cortical Nodule               13 (22%)      3 (33%)                                                         
      Cyst                                             1 (2%)                                                                       
      Hyperplasia, Focal                               5 (8%)                                                                       
      Necrosis                                         1 (2%)                                                                       
      X-Zone, Degeneration, Fatty                      1 (2%)                                                                       
   Adrenal Gland, Medulla                             (60)         (9)                                                              
      Hyperplasia                                      3 (5%)                                                                       
   Islets, Pancreatic                                 (60)         (10)                                                             
      Hyperplasia                                      8 (13%)      1 (10%)                                                         
   Parathyroid Gland                                  (58)         (10)                                                             
      Cyst                                             1 (2%)                                                                       
      Ectopic Thymus                                                1 (10%)                                                         
   Pituitary Gland                                    (60)         (9)                                                              
      Pars Distalis, Angiectasis                       2 (3%)                                                                       
      Pars Distalis, Hyperplasia                       7 (12%)                                                                      
   Thyroid Gland                                      (60)         (10)                                                             
      Degeneration, Cystic                            29 (48%)                                                                      
      Infiltration Cellular, Lymphocyte                1 (2%)                                                                       
      Inflammation, Subacute                           2 (3%)                                                                       
      Follicular Cell, Hyperplasia                    14 (23%)                                                                      
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   16                                                              
NTP Experiment-Test: 05089-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 09/11/94  
Route: DOSED WATER                                                                                                Time: 22:29:05  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        0.0275%      0.0275%                                                             
                                                                3 SSAC                                                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (2)                                                                           
      Ectasia                                          2 (100%)                                                                     
   Ovary                                              (56)         (9)                                                              
      Angiectasis                                      7 (13%)                                                                      
      Cyst                                            16 (29%)      1 (11%)                                                         
      Developmental Malformation                                    1 (11%)                                                         
      Hemorrhage                                                    1 (11%)                                                         
      Hyperplasia                                      2 (4%)                                                                       
      Hyperplasia, Cystic                              1 (2%)                                                                       
      Interstitial Cell, Hyperplasia                   1 (2%)                                                                       
   Uterus                                             (60)         (10)                                                             
      Angiectasis                                      3 (5%)                                                                       
      Hydrometra                                      21 (35%)                                                                      
      Hyperplasia, Cystic                             58 (97%)                                                                      
      Hyperplasia, Lymphoid                            1 (2%)                                                                       
      Inflammation, Suppurative                        3 (5%)                                                                       
      Metaplasia, Squamous                             3 (5%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (60)         (10)                                                             
      Angiectasis                                      1 (2%)                                                                       
      Hypercellularity                                 6 (10%)      1 (10%)                                                         
      Myelofibrosis                                    1 (2%)                                                                       
   Lymph Node                                         (60)         (10)                                                             
      Iliac, Hematopoietic Cell Proliferation          1 (2%)                                                                       
      Renal, Hematopoietic Cell Proliferation          1 (2%)                                                                       
      Renal, Hyperplasia, Plasma Cell                  1 (2%)                                                                       
   Lymph Node, Mandibular                             (58)         (10)                                                             
      Hyperplasia, Lymphoid                            1 (2%)                                                                       
   Lymph Node, Mesenteric                             (58)         (10)                                                             
      Hematopoietic Cell Proliferation                 1 (2%)                                                                       
      Hemorrhage                                       1 (2%)                                                                       
      Hyperplasia, Lymphoid                            2 (3%)                                                                       
      Lymphatic, Dilatation                            1 (2%)                                                                       
   Spleen                                             (60)         (10)                                                             
      Angiectasis                                      1 (2%)                                                                       
      Congestion                                       3 (5%)                                                                       
      Hematopoietic Cell Proliferation                22 (37%)      1 (10%)                                                         
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   17                                                              
NTP Experiment-Test: 05089-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 09/11/94  
Route: DOSED WATER                                                                                                Time: 22:29:05  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        0.0275%      0.0275%                                                             
                                                                3 SSAC                                                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Hyperplasia, Lymphoid                            1 (2%)                                                                       
      Pigmentation, Hemosiderin                        4 (7%)                                                                       
      Lymphoid Follicle, Atrophy                       4 (7%)                                                                       
      Lymphoid Follicle, Hyperplasia                   5 (8%)                                                                       
      Red Pulp, Hyperplasia                            3 (5%)                                                                       
   Thymus                                             (55)         (10)                                                             
      Angiectasis                                      3 (5%)                                                                       
      Cyst                                            10 (18%)                                                                      
      Depletion Cellular                               4 (7%)                                                                       
      Hyperplasia, Lymphoid                            1 (2%)                                                                       
      Epithelial Cell, Hyperplasia                     1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (60)         (10)                                                             
      Hyperplasia, Cystic                              2 (3%)                                                                       
      Hyperplasia, Lobular                                          1 (10%)                                                         
   Skin                                               (60)         (10)                                                             
      Acanthosis                                       1 (2%)                                                                       
      Inflammation, Chronic                            1 (2%)                                                                       
      Ulcer                                            1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (60)         (10)                                                             
      Hyperostosis                                     7 (12%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (60)         (10)                                                             
      Compression                                      1 (2%)                                                                       
      Hemorrhage                                       1 (2%)                                                                       
      Hydrocephalus                                    1 (2%)                                                                       
      Thalamus, Mineralization                        33 (55%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (10)                                                             
      Congestion                                       3 (5%)                                                                       
      Hemorrhage                                       7 (12%)      1 (10%)                                                         
      Hyperplasia, Lymphoid                           13 (22%)                                                                      
      Infiltration Cellular, Histiocyte                7 (12%)                                                                      
      Inflammation, Chronic                            1 (2%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   18                                                              
NTP Experiment-Test: 05089-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 09/11/94  
Route: DOSED WATER                                                                                                Time: 22:29:05  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        0.0275%      0.0275%                                                             
                                                                3 SSAC                                                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Alveolar Epithelium, Hyperplasia                 2 (3%)                                                                       
   Nose                                               (60)         (10)                                                             
      Exudate                                          5 (8%)                                                                       
      Glands, Hyperplasia, Cystic                      5 (8%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (2)                                                                           
      Cataract                                         1 (50%)                                                                      
      Retina, Atrophy                                  1 (50%)                                                                      
   Harderian Gland                                    (8)                                                                           
      Hyperplasia                                      1 (13%)                                                                      
      Hyperplasia, Focal                               3 (38%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (10)                                                             
      Casts Protein                                    7 (12%)                                                                      
      Cyst                                             5 (8%)                                                                       
      Glomerulosclerosis                               1 (2%)                                                                       
      Hemorrhage                                       1 (2%)                                                                       
      Hyperplasia, Lymphoid                           22 (37%)                                                                      
      Metaplasia, Osseous                              3 (5%)                                                                       
      Mineralization                                  13 (22%)                                                                      
      Interstitium, Pigmentation                       1 (2%)                                                                       
      Papilla, Necrosis                                1 (2%)                                                                       
      Renal Tubule, Atrophy                           10 (17%)                                                                      
      Renal Tubule, Dilatation                         1 (2%)                                                                       
      Renal Tubule, Pigmentation                       2 (3%)                                                                       
      Renal Tubule, Regeneration                      34 (57%)      1 (10%)                                                         
   Urinary Bladder                                    (60)         (10)                                                             
      Hyperplasia, Lymphoid                           20 (33%)                                                                      
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   19                                                              
NTP Experiment-Test: 05089-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 09/11/94  
Route: DOSED WATER                                                                                                Time: 22:29:05  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          VEHICLE      VEHICLE      0.00500%     0.00500%     0.00700%     0.00700%        
                                                   CONTROL      3 SSAC                     3 SSAC                    3 SSAC         
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          60           10           60           10           60           10           
  Scheduled Sacrifice                                 10           10           10           10           10           10           
  Early Deaths                                                                                                                      
    Natural Death                                      4                         3                         6                        
    Moribund Sacrifice                                12                        24                        16                        
  Survivors                                                                                                                         
    Terminal Sacrifice                                34                        23                        27                        
    Natural Death                                                                                          1                        
  Animals Examined Microscopically                    60           10           60                        60            3           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (53)         (9)          (50)                      (47)                      
      Cyst                                                                                                 1 (2%)                   
      Dilatation                                       1 (2%)                    1 (2%)                                             
   Intestine Large, Colon                             (59)         (9)          (50)                      (49)                      
      Diverticulum                                     1 (2%)                                                                       
   Intestine Small, Duodenum                          (59)         (10)         (50)                      (50)                      
      Hyperplasia, Lymphoid                            1 (2%)                                                                       
      Metaplasia, Squamous                             1 (2%)                                                                       
   Intestine Small, Ileum                             (58)         (10)         (49)                      (48)                      
      Hyperplasia, Lymphoid                            1 (2%)                                                                       
   Liver                                              (60)         (10)         (51)                      (50)                      
      Angiectasis                                                                                          2 (4%)                   
      Basophilic Focus                                 3 (5%)                    4 (8%)                    4 (8%)                   
      Clear Cell Focus                                11 (18%)                  11 (22%)                  12 (24%)                  
      Eosinophilic Focus                               1 (2%)                                                                       
      Hematopoietic Cell Proliferation                 1 (2%)                                                                       
      Hemorrhage                                                                                           1 (2%)                   
      Hepatodiaphragmatic Nodule                                                                           1 (2%)                   
      Hyperplasia, Focal                              14 (23%)                  21 (41%)                  18 (36%)                  
      Hyperplasia, Lymphoid                            1 (2%)                    1 (2%)                                             
      Inflammation, Acute                              1 (2%)       1 (10%)                                                         
      Inflammation, Chronic                            3 (5%)                    2 (4%)                    2 (4%)                   
      Inflammation, Chronic Active                     2 (3%)                                                                       
      Mixed Cell Focus                                 1 (2%)                    1 (2%)                    2 (4%)                   
      Centrilobular, Necrosis                                                    1 (2%)                    1 (2%)                   
      Hepatocyte, Cytomegaly                           7 (12%)                                                                      
      Hepatocyte, Karyomegaly                          2 (3%)                                              2 (4%)                   
      Hepatocyte, Vacuolization Cytoplasmic           11 (18%)                   2 (4%)                    4 (8%)                   
      Kupffer Cell, Hyperplasia                        4 (7%)                    3 (6%)                    4 (8%)                   
      Kupffer Cell, Pigmentation                                                 3 (6%)                                             
      Lobules, Necrosis                                3 (5%)                    7 (14%)                   8 (16%)                  
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   20                                                              
NTP Experiment-Test: 05089-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 09/11/94  
Route: DOSED WATER                                                                                                Time: 22:29:05  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          VEHICLE      VEHICLE      0.00500%     0.00500%     0.00700%     0.00700%        
                                                   CONTROL      3 SSAC                     3 SSAC                    3 SSAC         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
   Mesentery                                          (9)          (1)          (7)                       (3)                       
      Accessory Spleen                                                                                     1 (33%)                  
      Fibrosis                                         1 (11%)                                                                      
      Mineralization                                   1 (11%)                                                                      
      Fat, Necrosis                                    6 (67%)                   5 (71%)                   1 (33%)                  
   Pancreas                                           (60)         (10)         (50)                      (50)                      
      Atrophy                                          6 (10%)                   3 (6%)                    4 (8%)                   
      Cytoplasmic Alteration                           4 (7%)                                              1 (2%)                   
      Focal Cellular Change                            2 (3%)                                              1 (2%)                   
      Inflammation, Chronic                            1 (2%)                                                                       
   Salivary Glands                                    (60)         (10)         (50)                      (50)                      
      Atrophy                                          1 (2%)                                                                       
      Hyperplasia, Lymphoid                           21 (35%)                  13 (26%)                  13 (26%)                  
   Stomach, Forestomach                               (60)         (10)         (48)                      (50)                      
      Edema                                                                      1 (2%)                                             
      Erosion                                          1 (2%)                                                                       
      Hyperkeratosis                                   1 (2%)                                                                       
      Inflammation, Subacute                                                                               1 (2%)                   
      Ulcer                                                                                                1 (2%)                   
      Mucosa, Hyperplasia                              1 (2%)                    1 (2%)                    2 (4%)                   
   Stomach, Glandular                                 (60)         (10)         (48)                      (50)                      
      Cyst                                            13 (22%)                  11 (23%)                   5 (10%)                  
      Erosion                                                                                              4 (8%)                   
      Inflammation, Subacute                           1 (2%)                    2 (4%)                                             
      Metaplasia, Squamous                             1 (2%)                    1 (2%)                                             
      Mineralization                                   2 (3%)                    5 (10%)                                            
      Mucosa, Dysplasia                                1 (2%)                    1 (2%)                                             
      Mucosa, Hyperplasia                                                                                  2 (4%)                   
   Tooth                                              (17)                      (11)                      (7)                       
      Dysplasia                                       17 (100%)                 11 (100%)                  7 (100%)                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                                                 (1)                                                 
      Hypertrophy                                                                1 (100%)                                           
      Inflammation, Chronic                                                      1 (100%)                                           
   Heart                                              (60)         (10)         (50)                      (50)                      
      Epicardium, Inflammation, Chronic                2 (3%)                                                                       
      Myocardium, Fibrosis                             1 (2%)                                                                       
      Myocardium, Inflammation, Chronic                3 (5%)                                              1 (2%)                   
      Myocardium, Mineralization                                                 2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   21                                                              
NTP Experiment-Test: 05089-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 09/11/94  
Route: DOSED WATER                                                                                                Time: 22:29:05  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          VEHICLE      VEHICLE      0.00500%     0.00500%     0.00700%     0.00700%        
                                                   CONTROL      3 SSAC                     3 SSAC                    3 SSAC         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (60)         (10)         (50)                      (50)                      
      Accessory Adrenal Cortical Nodule                3 (5%)       1 (10%)      4 (8%)                    7 (14%)                  
      Basophilic Focus                                 2 (3%)                                              2 (4%)                   
      Clear Cell Focus                                 3 (5%)                    7 (14%)                   6 (12%)                  
      Cyst                                                                       1 (2%)                                             
      Hyperplasia, Diffuse                             1 (2%)                                                                       
      Hyperplasia, Focal                              31 (52%)                  24 (48%)                  20 (40%)                  
      Hypertrophy, Focal                               2 (3%)                    1 (2%)                    1 (2%)                   
      Mineralization                                   1 (2%)                                                                       
      Capsule, Hyperplasia                            11 (18%)                  11 (22%)                  11 (22%)                  
   Adrenal Gland, Medulla                             (59)         (10)         (50)                      (50)                      
      Hyperplasia                                      3 (5%)                                                                       
   Islets, Pancreatic                                 (60)         (10)         (50)                      (50)                      
      Cyst                                             1 (2%)                    1 (2%)                                             
      Hyperplasia                                     38 (63%)                  27 (54%)                  26 (52%)                  
   Parathyroid Gland                                  (59)         (10)         (47)                      (48)                      
      Cyst                                             2 (3%)       1 (10%)      2 (4%)                                             
   Pituitary Gland                                    (58)         (9)          (45)                      (49)                      
      Pars Distalis, Angiectasis                       1 (2%)                                                                       
      Pars Distalis, Cyst                              3 (5%)                    3 (7%)                    1 (2%)                   
      Pars Distalis, Hyperplasia                       1 (2%)                                                                       
   Thyroid Gland                                      (60)         (10)         (49)                      (50)                      
      Degeneration, Cystic                            12 (20%)                  17 (35%)                  14 (28%)                  
      Inflammation, Subacute                                                                               3 (6%)                   
      Follicle, Cyst                                                             3 (6%)                    1 (2%)                   
      Follicle, Inflammation, Suppurative              1 (2%)                                                                       
      Follicular Cell, Hyperplasia                     5 (8%)                    2 (4%)                    7 (14%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Coagulating Gland                                  (8)                       (8)                       (7)                       
      Dilatation                                       8 (100%)                  8 (100%)                  6 (86%)                  
      Inflammation, Suppurative                        1 (13%)                                                                      
   Epididymis                                         (60)         (9)          (50)                      (50)                      
      Atypia Cellular                                                            2 (4%)                                             
      Granuloma Sperm                                  1 (2%)                                                                       
      Hyperplasia, Lymphoid                                                      1 (2%)                                             
      Inflammation, Chronic                                                      2 (4%)                                             
      Spermatocele                                                               1 (2%)                                             
   Preputial Gland                                    (4)                       (10)                      (11)                      
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   22                                                              
NTP Experiment-Test: 05089-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 09/11/94  
Route: DOSED WATER                                                                                                Time: 22:29:05  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          VEHICLE      VEHICLE      0.00500%     0.00500%     0.00700%     0.00700%        
                                                   CONTROL      3 SSAC                     3 SSAC                    3 SSAC         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Ectasia                                          4 (100%)                  9 (90%)                   9 (82%)                  
      Inflammation, Chronic                                                      2 (20%)                   1 (9%)                   
   Prostate                                           (60)         (10)         (50)                      (49)                      
      Cyst                                             1 (2%)                                                                       
      Inflammation, Chronic                            2 (3%)                                              2 (4%)                   
      Inflammation, Suppurative                        1 (2%)                                                                       
      Epithelium, Hyperplasia                                                    1 (2%)                                             
   Seminal Vesicle                                    (60)         (10)         (51)                      (50)                      
      Dilatation                                      20 (33%)                  19 (37%)                  22 (44%)                  
      Fibrosis                                         1 (2%)                                              1 (2%)                   
      Hemorrhage                                                                 1 (2%)                    1 (2%)                   
      Inflammation, Chronic                            1 (2%)                                              2 (4%)                   
   Testes                                             (60)         (10)         (50)                      (50)                      
      Congestion                                                                 1 (2%)                                             
      Hemorrhage                                                                 1 (2%)                                             
      Mineralization                                   1 (2%)                                                                       
      Seminiferous Tubule, Atrophy                     2 (3%)                    4 (8%)                    1 (2%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (60)         (10)         (50)                      (50)                      
      Angiectasis                                      1 (2%)                    1 (2%)                                             
      Hypercellularity                                 3 (5%)                    4 (8%)                    2 (4%)                   
      Necrosis                                         1 (2%)                                                                       
   Lymph Node                                         (60)         (10)         (50)                      (50)                      
      Bronchial, Hyperplasia, Lymphoid                 1 (2%)                                                                       
      Mediastinal, Hematopoietic Cell Proliferation                              1 (2%)                                             
      Mediastinal, Hyperplasia, Lymphoid                                         1 (2%)                                             
      Mediastinal, Hyperplasia, Plasma Cell            1 (2%)                                                                       
   Lymph Node, Mandibular                             (58)         (10)         (46)                      (48)                      
      Hemorrhage                                       1 (2%)                                                                       
      Hyperplasia, Lymphoid                            2 (3%)                    1 (2%)                    2 (4%)                   
      Hyperplasia, Plasma Cell                         3 (5%)                    1 (2%)                    2 (4%)                   
   Lymph Node, Mesenteric                             (56)         (10)         (50)                      (48)                      
      Depletion Cellular                               1 (2%)                                                                       
      Hematopoietic Cell Proliferation                 6 (11%)                   3 (6%)                    6 (13%)                  
      Hemorrhage                                      24 (43%)                  15 (30%)                  20 (42%)                  
      Hyperplasia, Histiocytic                         1 (2%)                                                                       
      Hyperplasia, Lymphoid                            6 (11%)                   2 (4%)                    1 (2%)                   
      Hyperplasia, Plasma Cell                                                   2 (4%)                    1 (2%)                   
      Inflammation, Suppurative                                                                            1 (2%)                   
   Spleen                                             (60)         (10)         (50)                      (50)                      
      Angiectasis                                                                2 (4%)                                             
      Hematopoietic Cell Proliferation                10 (17%)                  13 (26%)                  12 (24%)                  
      Pigmentation, Hemosiderin                                                  2 (4%)                    1 (2%)                   
      Lymphoid Follicle, Atrophy                                                 2 (4%)                    3 (6%)                   
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   23                                                              
NTP Experiment-Test: 05089-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 09/11/94  
Route: DOSED WATER                                                                                                Time: 22:29:05  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          VEHICLE      VEHICLE      0.00500%     0.00500%     0.00700%     0.00700%        
                                                   CONTROL      3 SSAC                     3 SSAC                    3 SSAC         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Lymphoid Follicle, Hyperplasia                   4 (7%)                    4 (8%)                    2 (4%)                   
      Red Pulp, Atrophy                                2 (3%)                                                                       
      Red Pulp, Hyperplasia                            3 (5%)                                              2 (4%)                   
   Thymus                                             (56)         (9)          (41)                      (43)                      
      Cyst                                            10 (18%)                   5 (12%)                   8 (19%)                  
      Depletion Cellular                              11 (20%)                   9 (22%)                  11 (26%)                  
      Hyperplasia, Lymphoid                            1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (60)         (10)         (50)                      (49)                      
      Acanthosis                                                                 1 (2%)                                             
      Inflammation, Chronic                            1 (2%)                    1 (2%)                    1 (2%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (60)         (10)         (50)                      (50)                      
      Hyperostosis                                                                                         1 (2%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (60)         (10)         (50)                      (50)                      
      Cyst                                                                                                 1 (2%)                   
      Hemorrhage                                                                                           2 (4%)                   
      Hydrocephalus                                    1 (2%)                                                                       
      Thalamus, Mineralization                        48 (80%)                  38 (76%)                  38 (76%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (10)         (53)                      (50)                      
      Congestion                                       2 (3%)                    1 (2%)                    2 (4%)                   
      Hemorrhage                                       2 (3%)                    3 (6%)                    3 (6%)                   
      Hyperplasia, Lymphoid                            6 (10%)                   4 (8%)                    3 (6%)                   
      Infiltration Cellular, Histiocyte               16 (27%)                   9 (17%)                   2 (4%)                   
      Metaplasia, Osseous                              1 (2%)                                                                       
      Alveolar Epithelium, Hyperplasia                 7 (12%)                   2 (4%)                    2 (4%)                   
      Artery, Mineralization                           1 (2%)                                                                       
   Nose                                               (60)         (10)         (50)                      (50)                      
      Exudate                                          8 (13%)                   5 (10%)                   8 (16%)                  
      Glands, Hyperplasia, Cystic                      6 (10%)                   3 (6%)                    4 (8%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   24                                                              
NTP Experiment-Test: 05089-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 09/11/94  
Route: DOSED WATER                                                                                                Time: 22:29:05  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          VEHICLE      VEHICLE      0.00500%     0.00500%     0.00700%     0.00700%        
                                                   CONTROL      3 SSAC                     3 SSAC                    3 SSAC         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                                                                    (1)                       
      Cornea, Inflammation, Suppurative                                                                    1 (100%)                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (10)         (60)                      (60)         (3)          
      Casts Protein                                   11 (18%)                  18 (30%)                  10 (17%)                  
      Cyst                                            28 (47%)                  24 (40%)                  25 (42%)                  
      Glomerulosclerosis                                                         2 (3%)                                             
      Granuloma                                                                  1 (2%)                    1 (2%)                   
      Hydronephrosis                                   3 (5%)                    3 (5%)                                             
      Hyperplasia, Lymphoid                           12 (20%)                  18 (30%)                  10 (17%)                  
      Inflammation, Chronic                            4 (7%)                    3 (5%)                    1 (2%)                   
      Metaplasia, Osseous                              2 (3%)                    1 (2%)                    1 (2%)                   
      Mineralization                                  57 (95%)                  54 (90%)                  56 (93%)                  
      Pigmentation, Cholesterol                                                                            1 (2%)                   
      Papilla, Necrosis                                                                                    1 (2%)                   
      Renal Tubule, Atrophy                            4 (7%)                   17 (28%)                  16 (27%)                  
      Renal Tubule, Dilatation                         7 (12%)                  14 (23%)                  15 (25%)                  
      Renal Tubule, Hyperplasia, Focal                                           1 (2%)                    1 (2%)                   
      Renal Tubule, Necrosis                           1 (2%)                                              2 (3%)                   
      Renal Tubule, Regeneration                      55 (92%)      1 (10%)     58 (97%)                  55 (92%)      3 (100%)    
      Transitional Epithelium, Hyperplasia                                       1 (2%)                    3 (5%)                   
   Urinary Bladder                                    (60)         (10)         (51)                      (50)                      
      Dilatation                                       1 (2%)                    1 (2%)                    1 (2%)                   
      Hemorrhage                                                                 1 (2%)                                             
      Hyperplasia, Lymphoid                            4 (7%)                    4 (8%)                    1 (2%)                   
      Inflammation, Chronic                            2 (3%)                    1 (2%)                                             
      Mucosa, Hyperplasia                                                        1 (2%)                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   25                                                              
NTP Experiment-Test: 05089-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 09/11/94  
Route: DOSED WATER                                                                                                Time: 22:29:05  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          0.0100%      0.0100%      0.0140%      0.0140%      0.0200%      0.0200%         
                                                                3 SSAC                    3 SSAC                    3 SSAC          
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          60           10           60           10           60           10           
  Scheduled Sacrifice                                 10           10           10           10            9           10           
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                13                        13                        10                        
    Natural Death                                      3                         2                         4                        
  Survivors                                                                                                                         
    Terminal Sacrifice                                34                        35                        37                        
  Animals Examined Microscopically                    60            2           60            1           60           10           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (48)                      (48)                      (58)         (9)          
      Cyst                                                                       1 (2%)                    1 (2%)                   
      Dilatation                                                                                           2 (3%)                   
   Intestine Large, Cecum                             (49)                      (49)                      (60)         (10)         
      Hyperplasia, Lymphoid                                                                                1 (2%)                   
   Liver                                              (52)                      (55)                      (60)         (10)         
      Angiectasis                                                                1 (2%)                                             
      Basophilic Focus                                 3 (6%)                    3 (5%)                    5 (8%)                   
      Clear Cell Focus                                13 (25%)                  16 (29%)                   4 (7%)                   
      Eosinophilic Focus                               2 (4%)                                                                       
      Hematopoietic Cell Proliferation                 1 (2%)                                              1 (2%)                   
      Hemorrhage                                                                 1 (2%)                                             
      Hyperplasia, Focal                              12 (23%)                  23 (42%)                   5 (8%)                   
      Hyperplasia, Lymphoid                                                                                1 (2%)                   
      Infarct                                                                                              1 (2%)                   
      Inflammation, Chronic                            2 (4%)                    3 (5%)                    2 (3%)                   
      Inflammation, Chronic Active                     1 (2%)                                              2 (3%)                   
      Metaplasia, Osseous                                                                                  1 (2%)                   
      Mineralization                                                             1 (2%)                    1 (2%)                   
      Mixed Cell Focus                                 3 (6%)                    1 (2%)                    3 (5%)                   
      Centrilobular, Necrosis                          2 (4%)                    2 (4%)                    1 (2%)                   
      Hepatocyte, Cytomegaly                           2 (4%)                    2 (4%)                    7 (12%)                  
      Hepatocyte, Karyomegaly                          2 (4%)                                              3 (5%)                   
      Hepatocyte, Vacuolization Cytoplasmic            6 (12%)                   6 (11%)                  11 (18%)                  
      Kupffer Cell, Hyperplasia                        2 (4%)                                              4 (7%)                   
      Kupffer Cell, Pigmentation                       2 (4%)                    1 (2%)                    1 (2%)                   
      Lobules, Necrosis                                7 (13%)                   4 (7%)                    6 (10%)                  
   Mesentery                                          (2)                       (4)                       (4)                       
      Hemorrhage                                       1 (50%)                                                                      
      Fat, Fungus                                                                1 (25%)                                            
      Fat, Inflammation, Pyogranulomatous                                        1 (25%)                                            
      Fat, Necrosis                                    1 (50%)                   2 (50%)                   4 (100%)                 
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   26                                                              
NTP Experiment-Test: 05089-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 09/11/94  
Route: DOSED WATER                                                                                                Time: 22:29:05  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          0.0100%      0.0100%      0.0140%      0.0140%      0.0200%      0.0200%         
                                                                3 SSAC                    3 SSAC                    3 SSAC          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
   Pancreas                                           (50)                      (51)                      (60)         (10)         
      Atrophy                                          5 (10%)                   4 (8%)                    1 (2%)                   
      Cyst                                             1 (2%)                                                                       
      Cytoplasmic Alteration                           2 (4%)                                              2 (3%)                   
      Hyperplasia, Lymphoid                            2 (4%)                                                                       
      Inflammation, Chronic                                                                                1 (2%)                   
      Acinar Cell, Dysplasia, Focal                                                                        1 (2%)                   
   Salivary Glands                                    (50)                      (50)                      (60)         (10)         
      Hyperplasia, Lymphoid                           15 (30%)                  13 (26%)                  13 (22%)                  
   Stomach, Forestomach                               (50)                      (50)                      (60)         (10)         
      Inflammation, Suppurative                        2 (4%)                                              1 (2%)                   
      Mucosa, Hyperplasia                              2 (4%)                    1 (2%)                    2 (3%)                   
   Stomach, Glandular                                 (50)                      (50)                      (60)         (10)         
      Cyst                                             8 (16%)                   6 (12%)                  10 (17%)                  
      Erosion                                                                    1 (2%)                                             
      Inflammation, Subacute                           1 (2%)                    3 (6%)                    1 (2%)       1 (10%)     
      Metaplasia, Squamous                                                                                 1 (2%)                   
      Mineralization                                   3 (6%)                    4 (8%)                    6 (10%)                  
      Mucosa, Hyperplasia                                                        1 (2%)                                             
   Tooth                                              (5)                       (6)                       (3)                       
      Dysplasia                                        5 (100%)                  5 (83%)                   3 (100%)                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)                      (50)                      (60)         (10)         
      Epicardium, Inflammation, Chronic                1 (2%)                                                                       
      Myocardium, Inflammation, Chronic                                          1 (2%)                    1 (2%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)                      (50)                      (60)         (10)         
      Accessory Adrenal Cortical Nodule                7 (14%)                   6 (12%)                   7 (12%)                  
      Atrophy                                          1 (2%)                                                                       
      Basophilic Focus                                                           1 (2%)                    2 (3%)                   
      Clear Cell Focus                                 3 (6%)                    6 (12%)                   3 (5%)                   
      Cyst                                                                       1 (2%)                                             
      Developmental Malformation                       1 (2%)                    2 (4%)                                             
      Hyperplasia, Focal                              31 (62%)                  26 (52%)                  21 (35%)                  
      Hypertrophy, Focal                               1 (2%)                                              1 (2%)                   
      Capsule, Hyperplasia                             6 (12%)                   4 (8%)                    4 (7%)                   
   Adrenal Gland, Medulla                             (50)                      (50)                      (60)         (10)         
      Atrophy                                          1 (2%)                                                                       
      Hyperplasia                                      1 (2%)                                                                       
   Islets, Pancreatic                                 (50)                      (50)                      (60)         (10)         
      Hyperplasia                                     26 (52%)                  29 (58%)                  18 (30%)                  
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   27                                                              
NTP Experiment-Test: 05089-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 09/11/94  
Route: DOSED WATER                                                                                                Time: 22:29:05  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          0.0100%      0.0100%      0.0140%      0.0140%      0.0200%      0.0200%         
                                                                3 SSAC                    3 SSAC                    3 SSAC          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
   Parathyroid Gland                                  (46)                      (45)                      (55)         (10)         
      Cyst                                                                       2 (4%)                    3 (5%)                   
   Pituitary Gland                                    (49)                      (49)                      (59)         (10)         
      Pars Distalis, Cyst                              6 (12%)                   7 (14%)                   3 (5%)                   
      Pars Distalis, Hyperplasia                       2 (4%)                                                                       
   Thyroid Gland                                      (49)                      (50)                      (59)         (10)         
      Degeneration, Cystic                            15 (31%)                  13 (26%)                  12 (20%)                  
      Ectopic Thymus                                   1 (2%)                                                           1 (10%)     
      Inflammation, Subacute                                                                               1 (2%)                   
      Follicle, Cyst                                   4 (8%)                    1 (2%)                    3 (5%)       1 (10%)     
      Follicular Cell, Hyperplasia                     6 (12%)                   4 (8%)                    8 (14%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Coagulating Gland                                  (5)                       (6)                       (2)                       
      Dilatation                                       5 (100%)                  5 (83%)                   2 (100%)                 
   Epididymis                                         (50)                      (50)                      (60)         (10)         
      Atypia Cellular                                  1 (2%)                                                                       
      Fibrosis                                                                   1 (2%)                                             
      Granuloma Sperm                                                                                      1 (2%)                   
      Inflammation, Chronic                            1 (2%)                    1 (2%)                    1 (2%)                   
   Preputial Gland                                    (6)                       (20)                      (7)                       
      Ectasia                                          6 (100%)                 18 (90%)                   7 (100%)                 
      Inflammation, Chronic                            2 (33%)                   9 (45%)                   1 (14%)                  
      Inflammation, Suppurative                                                  1 (5%)                                             
   Prostate                                           (51)                      (50)                      (60)         (10)         
      Concretion                                       1 (2%)                                                                       
      Hemorrhage                                                                 1 (2%)                                             
      Inflammation, Chronic                            1 (2%)                    2 (4%)                                             
      Inflammation, Suppurative                        1 (2%)                                              1 (2%)                   
   Seminal Vesicle                                    (50)                      (51)                      (60)         (10)         
      Dilatation                                      18 (36%)                  22 (43%)                   8 (13%)                  
      Hemorrhage                                                                 1 (2%)                                             
      Inflammation, Chronic                                                      2 (4%)                                 1 (10%)     
   Testes                                             (50)                      (50)                      (60)         (10)         
      Infarct                                          1 (2%)                                                                       
      Seminiferous Tubule, Atrophy                     1 (2%)                                              4 (7%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   28                                                              
NTP Experiment-Test: 05089-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 09/11/94  
Route: DOSED WATER                                                                                                Time: 22:29:05  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          0.0100%      0.0100%      0.0140%      0.0140%      0.0200%      0.0200%         
                                                                3 SSAC                    3 SSAC                    3 SSAC          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)                      (50)                      (60)         (10)         
      Angiectasis                                      1 (2%)                                                                       
      Hypercellularity                                 2 (4%)                    3 (6%)                    1 (2%)                   
   Lymph Node                                         (50)                      (50)                      (60)         (10)         
      Mediastinal, Hyperplasia, Lymphoid                                                                   1 (2%)                   
      Mediastinal, Hyperplasia, Plasma Cell                                                                1 (2%)                   
   Lymph Node, Mandibular                             (50)                      (48)                      (56)         (10)         
      Hemorrhage                                                                                                        1 (10%)     
      Hyperplasia, Lymphoid                                                      1 (2%)                    1 (2%)                   
      Hyperplasia, Plasma Cell                                                   1 (2%)                                             
   Lymph Node, Mesenteric                             (50)                      (50)                      (59)         (10)         
      Hematopoietic Cell Proliferation                 1 (2%)                    6 (12%)                   3 (5%)                   
      Hemorrhage                                      12 (24%)                  16 (32%)                  13 (22%)                  
      Hyperplasia, Lymphoid                            3 (6%)                    1 (2%)                    1 (2%)                   
      Hyperplasia, Plasma Cell                                                                             1 (2%)                   
   Spleen                                             (51)                      (51)                      (60)         (10)         
      Angiectasis                                                                1 (2%)                                             
      Congestion                                                                                           2 (3%)                   
      Hematopoietic Cell Proliferation                15 (29%)                   8 (16%)                  11 (18%)                  
      Lymphoid Follicle, Atrophy                       1 (2%)                    1 (2%)                    1 (2%)                   
      Lymphoid Follicle, Hyperplasia                   2 (4%)                    4 (8%)                    1 (2%)                   
      Red Pulp, Atrophy                                1 (2%)                    2 (4%)                    1 (2%)                   
   Thymus                                             (46)                      (46)                      (56)         (10)         
      Cyst                                             3 (7%)                    4 (9%)                    9 (16%)                  
      Depletion Cellular                               2 (4%)                    5 (11%)                   7 (13%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (50)                      (50)                      (60)         (10)         
      Acanthosis                                                                 1 (2%)                    1 (2%)                   
      Cyst Epithelial Inclusion                        1 (2%)                                                                       
      Inflammation, Chronic                            1 (2%)                                              1 (2%)                   
      Ulcer                                                                      1 (2%)                                             
      Hair Follicle, Cyst                              1 (2%)                                                                       
      Subcutaneous Tissue, Edema                                                 1 (2%)                    1 (2%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   29                                                              
NTP Experiment-Test: 05089-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 09/11/94  
Route: DOSED WATER                                                                                                Time: 22:29:05  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          0.0100%      0.0100%      0.0140%      0.0140%      0.0200%      0.0200%         
                                                                3 SSAC                    3 SSAC                    3 SSAC          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)                      (50)                      (60)         (10)         
      Thalamus, Mineralization                        44 (88%)                  43 (86%)                  47 (78%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (51)                      (52)                      (60)         (10)         
      Congestion                                                                 2 (4%)                    1 (2%)                   
      Embolus                                          1 (2%)                                                                       
      Hemorrhage                                       4 (8%)                    3 (6%)                    1 (2%)       1 (10%)     
      Hyperplasia, Lymphoid                            2 (4%)                    5 (10%)                   3 (5%)                   
      Infiltration Cellular, Histiocyte                9 (18%)                   6 (12%)                   8 (13%)                  
      Inflammation, Chronic                                                                                1 (2%)                   
      Thrombosis                                                                 1 (2%)                                             
      Alveolar Epithelium, Hyperplasia                                           2 (4%)                    3 (5%)                   
      Alveolar Epithelium, Hyperplasia, Focal          1 (2%)                                                                       
   Nose                                               (50)                      (50)                      (60)         (10)         
      Exudate                                          1 (2%)                    2 (4%)                    4 (7%)                   
      Foreign Body                                     1 (2%)                                                                       
      Glands, Hyperplasia, Cystic                      1 (2%)                    2 (4%)                    2 (3%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (2)          (60)         (1)          (60)         (10)         
      Casts Protein                                   14 (23%)                  12 (20%)                  12 (20%)                  
      Cyst                                            24 (40%)                  23 (38%)                  18 (30%)                  
      Glomerulosclerosis                                                         4 (7%)                                             
      Granuloma                                                                  2 (3%)                    3 (5%)                   
      Hydronephrosis                                   1 (2%)                    5 (8%)                                             
      Hyperplasia, Lymphoid                           18 (30%)                  15 (25%)                  12 (20%)                  
      Inflammation, Chronic                            4 (7%)                    5 (8%)                    3 (5%)                   
      Inflammation, Suppurative                                                  1 (2%)                                             
      Metaplasia, Osseous                              2 (3%)                    1 (2%)                                             
      Mineralization                                  54 (90%)                  54 (90%)                  56 (93%)                  
      Renal Tubule, Atrophy                            8 (13%)                  11 (18%)                  13 (22%)                  
      Renal Tubule, Degeneration, Focal                1 (2%)                                                                       
      Renal Tubule, Dilatation                        25 (42%)                  14 (23%)                  28 (47%)                  
      Renal Tubule, Hyperplasia, Focal                 2 (3%)                                              1 (2%)                   
      Renal Tubule, Necrosis                           2 (3%)                                              2 (3%)                   
      Renal Tubule, Regeneration                      56 (93%)      2 (100%)    59 (98%)      1 (100%)    57 (95%)      1 (10%)     
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   30                                                              
NTP Experiment-Test: 05089-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 09/11/94  
Route: DOSED WATER                                                                                                Time: 22:29:05  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          0.0100%      0.0100%      0.0140%      0.0140%      0.0200%      0.0200%         
                                                                3 SSAC                    3 SSAC                    3 SSAC          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Transitional Epithelium, Hyperplasia                                       1 (2%)                                             
   Urinary Bladder                                    (50)                      (50)                      (60)         (10)         
      Dilatation                                       1 (2%)                                              1 (2%)                   
      Hemorrhage                                                                 1 (2%)                                             
      Hyperplasia, Lymphoid                            4 (8%)                    2 (4%)                    5 (8%)                   
      Inflammation, Chronic                                                                                2 (3%)                   
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   31                                                              
NTP Experiment-Test: 05089-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 09/11/94  
Route: DOSED WATER                                                                                                Time: 22:29:05  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          0.0275%      0.0275%                                                             
                                                                3 SSAC                                                              
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          60           10                                                               
  Scheduled Sacrifice                                  9           10                                                               
  Early Deaths                                                                                                                      
    Natural Death                                      8                                                                            
    Moribund Sacrifice                                10                                                                            
    Accidently Killed                                  1                                                                            
  Survivors                                                                                                                         
    Terminal Sacrifice                                32                                                                            
  Animals Examined Microscopically                    60           10                                                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (56)         (9)                                                              
      Dilatation                                       2 (4%)                                                                       
   Intestine Small, Ileum                             (58)         (9)                                                              
      Hyperplasia, Lymphoid                            1 (2%)                                                                       
   Liver                                              (60)         (10)                                                             
      Basophilic Focus                                 4 (7%)                                                                       
      Clear Cell Focus                                 8 (13%)                                                                      
      Eosinophilic Focus                               2 (3%)                                                                       
      Hematopoietic Cell Proliferation                 1 (2%)                                                                       
      Hyperplasia, Focal                              13 (22%)                                                                      
      Inflammation, Chronic                            2 (3%)       1 (10%)                                                         
      Inflammation, Chronic Active                     1 (2%)                                                                       
      Bile Duct, Cyst                                  1 (2%)                                                                       
      Centrilobular, Necrosis                          1 (2%)                                                                       
      Hepatocyte, Cytomegaly                           2 (3%)                                                                       
      Hepatocyte, Karyomegaly                          1 (2%)                                                                       
      Hepatocyte, Vacuolization Cytoplasmic            6 (10%)      1 (10%)                                                         
      Kupffer Cell, Hyperplasia                        1 (2%)                                                                       
      Kupffer Cell, Pigmentation                       3 (5%)                                                                       
      Lobules, Necrosis                                5 (8%)                                                                       
   Mesentery                                          (3)          (1)                                                              
      Inflammation, Chronic                                         1 (100%)                                                        
      Fat, Necrosis                                    2 (67%)                                                                      
   Pancreas                                           (60)         (10)                                                             
      Atrophy                                          4 (7%)                                                                       
      Cytoplasmic Alteration                           2 (3%)                                                                       
      Focal Cellular Change                            1 (2%)                                                                       
      Inflammation, Chronic                                         1 (10%)                                                         
   Salivary Glands                                    (60)         (10)                                                             
      Hyperplasia, Lymphoid                           19 (32%)                                                                      
   Stomach, Forestomach                               (59)         (10)                                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   32                                                              
NTP Experiment-Test: 05089-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 09/11/94  
Route: DOSED WATER                                                                                                Time: 22:29:05  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          0.0275%      0.0275%                                                             
                                                                3 SSAC                                                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Diverticulum                                     2 (3%)                                                                       
      Edema                                            1 (2%)                                                                       
   Stomach, Glandular                                 (59)         (10)                                                             
      Cyst                                             8 (14%)      1 (10%)                                                         
      Edema                                            1 (2%)                                                                       
      Inflammation, Subacute                           4 (7%)                                                                       
      Metaplasia, Squamous                             1 (2%)                                                                       
      Mineralization                                   1 (2%)                                                                       
      Ulcer                                            1 (2%)                                                                       
   Tooth                                              (7)                                                                           
      Dysplasia                                        6 (86%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (60)         (10)                                                             
      Epicardium, Inflammation, Chronic                1 (2%)                                                                       
      Myocardium, Inflammation, Chronic                1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (60)         (9)                                                              
      Accessory Adrenal Cortical Nodule                5 (8%)                                                                       
      Clear Cell Focus                                 9 (15%)                                                                      
      Hyperplasia, Focal                              31 (52%)                                                                      
      Capsule, Hyperplasia                            10 (17%)                                                                      
      Capsule, Hyperplasia, Focal                      1 (2%)                                                                       
   Adrenal Gland, Medulla                             (60)         (9)                                                              
      Developmental Malformation                       1 (2%)                                                                       
      Hyperplasia                                      1 (2%)                                                                       
      Hyperplasia, Focal                               1 (2%)                                                                       
   Islets, Pancreatic                                 (60)         (10)                                                             
      Hyperplasia                                     24 (40%)                                                                      
   Parathyroid Gland                                  (58)         (9)                                                              
      Cyst                                             2 (3%)                                                                       
   Pituitary Gland                                    (58)         (10)                                                             
      Pars Distalis, Cyst                              2 (3%)                                                                       
      Pars Distalis, Hyperplasia                       5 (9%)                                                                       
   Thyroid Gland                                      (60)         (10)                                                             
      Degeneration, Cystic                            16 (27%)                                                                      
      Follicle, Cyst                                   4 (7%)                                                                       
      Follicular Cell, Hyperplasia                     3 (5%)                                                                       
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   33                                                              
NTP Experiment-Test: 05089-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 09/11/94  
Route: DOSED WATER                                                                                                Time: 22:29:05  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          0.0275%      0.0275%                                                             
                                                                3 SSAC                                                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Coagulating Gland                                  (4)                                                                           
      Dilatation                                       4 (100%)                                                                     
   Epididymis                                         (60)         (9)                                                              
      Atypia Cellular                                  1 (2%)                                                                       
      Inflammation, Chronic                            2 (3%)                                                                       
   Preputial Gland                                    (7)                                                                           
      Ectasia                                          6 (86%)                                                                      
      Inflammation, Chronic                            3 (43%)                                                                      
   Seminal Vesicle                                    (60)         (10)                                                             
      Dilatation                                      14 (23%)                                                                      
      Fibrosis                                         1 (2%)                                                                       
   Testes                                             (60)         (10)                                                             
      Mineralization                                   1 (2%)                                                                       
      Interstitial Cell, Hyperplasia                   1 (2%)                                                                       
      Seminiferous Tubule, Atrophy                     3 (5%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (60)         (10)                                                             
      Angiectasis                                      1 (2%)                                                                       
      Hypercellularity                                 4 (7%)                                                                       
   Lymph Node                                         (60)         (10)                                                             
      Mediastinal, Hemorrhage                          1 (2%)                                                                       
   Lymph Node, Mesenteric                             (59)         (8)                                                              
      Hematopoietic Cell Proliferation                 1 (2%)                                                                       
      Hemorrhage                                      17 (29%)                                                                      
      Hyperplasia, Lymphoid                            4 (7%)                                                                       
   Spleen                                             (60)         (10)                                                             
      Angiectasis                                      2 (3%)                                                                       
      Congestion                                       1 (2%)                                                                       
      Hematopoietic Cell Proliferation                11 (18%)                                                                      
      Red Pulp, Atrophy                                1 (2%)                                                                       
      Red Pulp, Hyperplasia                            1 (2%)                                                                       
   Thymus                                             (58)         (10)                                                             
      Cyst                                            10 (17%)                                                                      
      Depletion Cellular                               8 (14%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   34                                                              
NTP Experiment-Test: 05089-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 09/11/94  
Route: DOSED WATER                                                                                                Time: 22:29:05  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          0.0275%      0.0275%                                                             
                                                                3 SSAC                                                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (60)         (10)                                                             
      Fat, Necrosis                                    1 (2%)                                                                       
      Subcutaneous Tissue, Fibrosis, Focal             1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (60)         (10)                                                             
      Hyperostosis                                     1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (60)         (10)                                                             
      Metaplasia, Osseous                              1 (2%)                                                                       
      Thalamus, Mineralization                        48 (80%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (10)                                                             
      Congestion                                       3 (5%)                                                                       
      Hemorrhage                                       2 (3%)       1 (10%)                                                         
      Hyperplasia, Lymphoid                            2 (3%)                                                                       
      Infiltration Cellular, Histiocyte                7 (12%)                                                                      
      Inflammation, Chronic                            1 (2%)                                                                       
      Leukocytosis                                     1 (2%)                                                                       
      Alveolar Epithelium, Hyperplasia                 4 (7%)                                                                       
   Nose                                               (60)         (10)                                                             
      Exudate                                          1 (2%)                                                                       
      Glands, Hyperplasia, Cystic                      4 (7%)                                                                       
   Trachea                                            (60)         (10)                                                             
      Inflammation, Suppurative                        2 (3%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (10)                                                             
      Casts Protein                                   11 (18%)                                                                      
      Cyst                                            26 (43%)                                                                      
      Glomerulosclerosis                               1 (2%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   35                                                              
NTP Experiment-Test: 05089-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 09/11/94  
Route: DOSED WATER                                                                                                Time: 22:29:05  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          0.0275%      0.0275%                                                             
                                                                3 SSAC                                                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
      Granuloma                                        4 (7%)                                                                       
      Hydronephrosis                                   1 (2%)                                                                       
      Hyperplasia, Lymphoid                           18 (30%)                                                                      
      Inflammation, Chronic                            2 (3%)                                                                       
      Metaplasia, Osseous                              1 (2%)                                                                       
      Mineralization                                  48 (80%)                                                                      
      Renal Tubule, Atrophy                            7 (12%)                                                                      
      Renal Tubule, Dilatation                        29 (48%)                                                                      
      Renal Tubule, Hyperplasia, Focal                 2 (3%)                                                                       
      Renal Tubule, Pigmentation                       1 (2%)                                                                       
      Renal Tubule, Regeneration                      53 (88%)                                                                      
      Renal Tubule, Vacuolization Cytoplasmic                       1 (10%)                                                         
   Urinary Bladder                                    (60)         (10)                                                             
      Dilatation                                       3 (5%)                                                                       
      Hyperplasia, Lymphoid                            5 (8%)                                                                       
      Inflammation, Chronic                            2 (3%)                                                                       
      Mucosa, Hyperplasia                              1 (2%)                                                                       
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   36                                                              
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