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TR 392 Mouse Pathology Tables

NTP Experiment-Test: 05089-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97
Route: DOSED WATER                                                                                                Time: 15:57:00




       Facility:  Southern Research Institute

       Chemical CAS #:   10599903

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All






































                                                              Page   1

NTP Experiment-Test: 05089-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 15:57:00  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 6| 6| 7| 7| 7| 6| 7| 6| 7| 7|             
                             DAY ON TEST   | 3| 8| 6| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 8| 3| 9| 5| 3| 3| 3| 9| 3| 9| 3| 3|             
                                           | 6| 1| 1| 6| 6| 6| 6| 8| 7| 7| 7| 7| 4| 8| 4| 4| 9| 4| 4| 4| 5| 4| 5| 4| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|             
    VEHICLE                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
    CONTROL                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |          X        X                                               X      |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                        2                                 |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Artery, Jejunum, Necrosis, Fibrinoid |                                        4                                 |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                              3  4                        |             
      Clear Cell Focus                     |                                                                X         |             
      Hematopoietic Cell Proliferation     |                                                 1        1               |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Focal                   |             2  3  2        3  1                    2              4      |             
      Hyperplasia, Lymphoid                |             1     1     1                                            1   |             
      Infiltration Cellular, Mononuclear   |                                                                          |             
          Cell                             |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Subacute               |                                              3              1            |             
      Mineralization                       |                                                                          |             
      Mixed Cell Focus                     |                                                                X         |             
      Artery, Necrosis, Fibrinoid          |                                        4                                 |             
      Hepatocyte, Karyomegaly              |                                                                          |             
      Hepatocyte, Vacuolization Cytoplasmic|                         2                                                |             
      Kupffer Cell, Hyperplasia            |                                                                          |             
      Kupffer Cell, Pigmentation           |                                                                          |             
      Lobules, Necrosis                    |                1                    1                                    |             
                                            __________________________________________________________________________|             
   Mesentery                               |                +  +                    +  +                 +     +  +   |             
      Edema                                |                                                                          |             
      Artery, Necrosis, Fibrinoid          |                                        4                                 |             
      Fat, Inflammation, Suppurative       |                                                                          |             
      Fat, Necrosis                        |                4  2                       3                 4     2  3   |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                     2           1                        |             
      Cytoplasmic Alteration               |    2                                            3                        |             
      Focal Cellular Change                |                                                                X         |             
      Hyperplasia, Lymphoid                | 1                          2        2                                    |             
      Inflammation, Subacute               |       3                                                                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05089-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 15:57:00  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 6| 6| 7| 7| 7| 6| 7| 6| 7| 7|             
                             DAY ON TEST   | 3| 8| 6| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 8| 3| 9| 5| 3| 3| 3| 9| 3| 9| 3| 3|             
                                           | 6| 1| 1| 6| 6| 6| 6| 8| 7| 7| 7| 7| 4| 8| 4| 4| 9| 4| 4| 4| 5| 4| 5| 4| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|             
    VEHICLE                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
    CONTROL                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |       1  2  1                                1  1        3               |             
      Acinus, Hyperplasia, Cystic          |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Diverticulum                         |                                                                          |             
      Edema                                |                                        2                                 |             
      Inflammation, Suppurative            |       2                                                                  |             
      Ulcer                                |                                                                          |             
      Mucosa, Hyperplasia                  |       2                                                                  |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 | X                 X                       X                              |             
      Edema                                |                                        2        2                        |             
      Erosion                              |    2                                                                     |             
      Inflammation, Subacute               |                            2                                             |             
      Metaplasia, Squamous                 |                                                                          |             
      Mineralization                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                        +                                 |             
      Necrosis, Fibrinoid                  |                                        4                                 |             
      Thrombosis                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Myocardium, Inflammation, Subacute   |                                                 3                        |             
      Myocardium, Mineralization           |                                                 1                        |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                                        X              X        X     X   |             
      Basophilic Focus                     |                                                                          |             
      Clear Cell Focus                     |                                                          X               |             
      Hyperplasia, Focal                   |                         2                          1                     |             
      Capsule, Hyperplasia                 |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                  1                                       |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Hyperplasia                          |                                  4                                   1   |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Ectopic Thymus                       |                                                                          |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05089-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 15:57:00  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 6| 6| 7| 7| 7| 6| 7| 6| 7| 7|             
                             DAY ON TEST   | 3| 8| 6| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 8| 3| 9| 5| 3| 3| 3| 9| 3| 9| 3| 3|             
                                           | 6| 1| 1| 6| 6| 6| 6| 8| 7| 7| 7| 7| 4| 8| 4| 4| 9| 4| 4| 4| 5| 4| 5| 4| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|             
    VEHICLE                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
    CONTROL                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pars Distalis, Angiectasis           |                                  3                                2      |             
      Pars Distalis, Hyperplasia           |             2                    2                    1                  |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 |    1  3        1              2        3        1     2  1        1     2|             
      Inflammation, Subacute               |                                           1                              |             
      Follicle, Cyst                       |                            X        X                                    |             
      Follicular Cell, Hyperplasia         |          1                          2     1  1                       1   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  M  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                      2           2           2              2  2        2|             
      Cyst                                 |             X  X        X        X                             X         |             
      Hyperplasia                          |                                                                          |             
      Artery, Necrosis, Fibrinoid          |                                        4                                 |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                2                             4     2                     |             
      Hydrometra                           |       3           4     3     4              4              4  4     2   |             
      Hyperplasia, Cystic                  | 3  3  3  2  4  2  3  3  3  4  3  2  3  2  3  1  2  3  3  3  4  4  2  3  3|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Inflammation, Suppurative            |       3                                                                  |             
      Metaplasia, Squamous                 |                                                             2            |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hypercellularity                     |       3              2              2           3                        |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Artery, Necrosis, Fibrinoid          |                                        4                                 |             
      Iliac, Angiectasis                   |                4     4                                                   |             
      Iliac, Hyperplasia, Plasma Cell      |       4                                         3                        |             
      Renal, Hyperplasia, Plasma Cell      |       3                                                                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +|             
      Hyperplasia, Lymphoid                |             2                          3                             1   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                        2                                 |             
      Hyperplasia, Plasma Cell             | 3                 2                                                      |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |       3        4     3        2     2  1        3  3     1           1   |             
      Hemorrhage                           |                                                                          |             
      Necrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05089-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 15:57:00  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 6| 6| 7| 7| 7| 6| 7| 6| 7| 7|             
                             DAY ON TEST   | 3| 8| 6| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 8| 3| 9| 5| 3| 3| 3| 9| 3| 9| 3| 3|             
                                           | 6| 1| 1| 6| 6| 6| 6| 8| 7| 7| 7| 7| 4| 8| 4| 4| 9| 4| 4| 4| 5| 4| 5| 4| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|             
    VEHICLE                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
    CONTROL                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Pigmentation, Hemosiderin            |                                     2                       2            |             
      Lymphoid Follicle, Atrophy           |                                                 2                        |             
      Lymphoid Follicle, Hyperplasia       |                                                                      3   |             
      Red Pulp, Hyperplasia                |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Cyst                                 |                            X           X              X     X  X         |             
      Depletion Cellular                   |       3                                         3                        |             
      Ectopic Parathyroid Gland            |                                        X                                 |             
      Hyperplasia, Lymphoid                |                                        4                             3   |             
      Artery, Necrosis, Fibrinoid          |                                        4                                 |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Subcutaneous Tissue, Edema           |                                        3                                 |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |                                                                          |             
      Hyperostosis                         |                                        2                                 |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Thalamus, Mineralization             | 1  2  3     2  2  1  1  3  3        1  1  2  2  3  3  3  2  3  1  2      |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                              2                           |             
      Edema                                |                                                                          |             
      Hemorrhage                           |                                                                   2      |             
      Hyperplasia, Lymphoid                |             1           1  2              1        1                 2   |             
      Infiltration Cellular, Histiocyte    |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                              3                           |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Exudate                              |             X                                                            |             
      Glands, Hyperplasia, Cystic          |             1                                                     1      |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05089-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 15:57:00  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 5| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5| 7| 6| 6| 7| 7| 7| 6| 7| 6| 7| 7|             
                             DAY ON TEST   | 3| 8| 6| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 8| 3| 9| 5| 3| 3| 3| 9| 3| 9| 3| 3|             
                                           | 6| 1| 1| 6| 6| 6| 6| 8| 7| 7| 7| 7| 4| 8| 4| 4| 9| 4| 4| 4| 5| 4| 5| 4| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7|             
    VEHICLE                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
    CONTROL                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Casts Protein                        |                1                       3  1              1           1   |             
      Glomerulosclerosis                   |                                        2                                 |             
      Hydronephrosis                       |                                        2        4                        |             
      Hyperplasia, Lymphoid                | 1     1  1  3              2        2  2     1        1  1  1        2   |             
      Inflammation, Suppurative            |                                                 3                        |             
      Metaplasia, Osseous                  |                               3                                          |             
      Mineralization                       |                   2        1  1  1              3           1  1     1  2|             
      Papilla, Necrosis                    |                                                 4                        |             
      Renal Tubule, Atrophy                |                      2                 2  2                              |             
      Renal Tubule, Dilatation             |                                        3     1  3                        |             
      Renal Tubule, Necrosis               |                                                 4                        |             
      Renal Tubule, Regeneration           | 1  3     1  1  1  2  2     1  1  1  1  3     1        1  1     1        1|             
      Transitional Epithelium, Hyperplasia |                                                 4                        |             
                                            __________________________________________________________________________|             
   Ureter                                  |                                                 +                        |             
      Dilatation                           |                                                 3                        |             
      Inflammation, Suppurative            |                                                 3                        |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                                                          |             
      Hyperplasia, Lymphoid                |          2           2        1  1     2  2  1  3  2                 1   |             
      Inflammation, Subacute               |                                                 3                        |             
      Mucosa, Hyperplasia                  |                                                 2                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   6                                                               
NTP Experiment-Test: 05089-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 15:57:00  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 6| 6| 7| 7| 7| 0| 7| 5| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 5| 7|             
                             DAY ON TEST   | 5| 5| 5| 5| 5| 8| 8| 3| 3| 3| 1| 3| 1| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 1| 3|             
                                           | 5| 6| 7| 5| 6| 8| 1| 6| 6| 7| 6| 3| 0| 1| 3| 3| 6| 3| 6| 3| 3| 6| 6| 8| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 2| 2| 2| 2| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                               ANIMAL ID   | 7| 7| 7| 7| 8| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
    VEHICLE                                | 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    CONTROL                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Inflammation, Chronic                |    1                                                                     |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  I  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Artery, Jejunum, Necrosis, Fibrinoid |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                                                          |             
      Clear Cell Focus                     |                                                                          |             
      Hematopoietic Cell Proliferation     |                1  2                                3                     |             
      Hemorrhage                           |       1                                                                  |             
      Hyperplasia, Focal                   |                                                                3         |             
      Hyperplasia, Lymphoid                |                            1                                             |             
      Infiltration Cellular, Mononuclear   |                                                                          |             
          Cell                             |       1                                                                  |             
      Inflammation, Chronic                | 1                                                                        |             
      Inflammation, Subacute               |          1  1                                                            |             
      Mineralization                       |                                                                          |             
      Mixed Cell Focus                     |                                                                          |             
      Artery, Necrosis, Fibrinoid          |                                                                          |             
      Hepatocyte, Karyomegaly              |                                        2                                 |             
      Hepatocyte, Vacuolization Cytoplasmic|          1                                                        2      |             
      Kupffer Cell, Hyperplasia            |                   2                                                      |             
      Kupffer Cell, Pigmentation           |                                        3                                 |             
      Lobules, Necrosis                    |                   1              2     1                                 |             
                                            __________________________________________________________________________|             
   Mesentery                               |                +     +                 +     +     +  +        +         |             
      Edema                                |                                                                          |             
      Artery, Necrosis, Fibrinoid          |                                                                          |             
      Fat, Inflammation, Suppurative       |                                                                          |             
      Fat, Necrosis                        |                                        2     3     3  2        4         |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Cytoplasmic Alteration               |                                                                          |             
      Focal Cellular Change                |                                                                          |             
      Hyperplasia, Lymphoid                |                3  1                             1     1  1               |             
      Inflammation, Subacute               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   7                                                               
NTP Experiment-Test: 05089-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 15:57:00  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 6| 6| 7| 7| 7| 0| 7| 5| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 5| 7|             
                             DAY ON TEST   | 5| 5| 5| 5| 5| 8| 8| 3| 3| 3| 1| 3| 1| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 1| 3|             
                                           | 5| 6| 7| 5| 6| 8| 1| 6| 6| 7| 6| 3| 0| 1| 3| 3| 6| 3| 6| 3| 3| 6| 6| 8| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 2| 2| 2| 2| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                               ANIMAL ID   | 7| 7| 7| 7| 8| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
    VEHICLE                                | 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    CONTROL                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Hyperplasia, Lymphoid                |    2     2  1     3        2     3  2  3     2  2        2        2  1  2|             
      Acinus, Hyperplasia, Cystic          |                   3                                                      |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                  X                                       |             
      Diverticulum                         |                3                                                         |             
      Edema                                |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Ulcer                                |                                                       1                  |             
      Mucosa, Hyperplasia                  |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 | X                          X              X                          X   |             
      Edema                                |                                                                          |             
      Erosion                              |                                                                          |             
      Inflammation, Subacute               |             2                          2                                 |             
      Metaplasia, Squamous                 |                                                                          |             
      Mineralization                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
      Necrosis, Fibrinoid                  |                                                                          |             
      Thrombosis                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Myocardium, Inflammation, Subacute   |                                                                          |             
      Myocardium, Mineralization           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |       X                                      X     X                    X|             
      Basophilic Focus                     |                                     X                          X        X|             
      Clear Cell Focus                     |                                                                          |             
      Hyperplasia, Focal                   |    2                                                                     |             
      Capsule, Hyperplasia                 |    1                                                              2      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                       1                  |             
      Hyperplasia                          |                                  2                                       |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectopic Thymus                       |                                                                          |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   8                                                               
NTP Experiment-Test: 05089-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 15:57:00  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 6| 6| 7| 7| 7| 0| 7| 5| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 5| 7|             
                             DAY ON TEST   | 5| 5| 5| 5| 5| 8| 8| 3| 3| 3| 1| 3| 1| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 1| 3|             
                                           | 5| 6| 7| 5| 6| 8| 1| 6| 6| 7| 6| 3| 0| 1| 3| 3| 6| 3| 6| 3| 3| 6| 6| 8| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 2| 2| 2| 2| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                               ANIMAL ID   | 7| 7| 7| 7| 8| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
    VEHICLE                                | 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    CONTROL                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pars Distalis, Angiectasis           |                2                                                         |             
      Pars Distalis, Hyperplasia           | 1              2                          1                    2         |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 |    1        1  2  2  3              2  2        1  1  1        2  2  1  1|             
      Inflammation, Subacute               |                                                                          |             
      Follicle, Cyst                       |                                                                          |             
      Follicular Cell, Hyperplasia         |                            1     2        1  1           1     1         |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                2                    2                 3              2  3|             
      Cyst                                 |                X        X        X     X           X                     |             
      Hyperplasia                          |                                                                          |             
      Artery, Necrosis, Fibrinoid          |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                  2  2                                    |             
      Hydrometra                           |                4     3     4           2  4  3     3           4        4|             
      Hyperplasia, Cystic                  | 2  3  3  3  3  2  3  2  3  2     4  4  2  1  2  1  2  3  3  3  3  2  2  3|             
      Hyperplasia, Lymphoid                |                                  2                                       |             
      Inflammation, Suppurative            |       2                                                                  |             
      Metaplasia, Squamous                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hypercellularity                     |                4  3                                4                     |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Artery, Necrosis, Fibrinoid          |                                                                          |             
      Iliac, Angiectasis                   |                                                                          |             
      Iliac, Hyperplasia, Plasma Cell      |                                                                          |             
      Renal, Hyperplasia, Plasma Cell      |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  I|             
      Hyperplasia, Lymphoid                |                                     2                    4               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                   3     1                                                |             
      Hemorrhage                           |                   1     2                                                |             
      Hyperplasia, Lymphoid                |                                        2     2                           |             
      Hyperplasia, Plasma Cell             |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                3  4  3     1     1     3     2     4                     |             
      Hemorrhage                           |                                                                          |             
      Necrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   9                                                               
NTP Experiment-Test: 05089-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 15:57:00  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 6| 6| 7| 7| 7| 0| 7| 5| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 5| 7|             
                             DAY ON TEST   | 5| 5| 5| 5| 5| 8| 8| 3| 3| 3| 1| 3| 1| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 1| 3|             
                                           | 5| 6| 7| 5| 6| 8| 1| 6| 6| 7| 6| 3| 0| 1| 3| 3| 6| 3| 6| 3| 3| 6| 6| 8| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 2| 2| 2| 2| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                               ANIMAL ID   | 7| 7| 7| 7| 8| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
    VEHICLE                                | 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    CONTROL                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Pigmentation, Hemosiderin            |                      2                                2        2         |             
      Lymphoid Follicle, Atrophy           |                                                                          |             
      Lymphoid Follicle, Hyperplasia       |                                  3  3                                    |             
      Red Pulp, Hyperplasia                |                                           3                    2         |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                        2                                 |             
      Cyst                                 |       X     X              X     X                                       |             
      Depletion Cellular                   |                                                    3                     |             
      Ectopic Parathyroid Gland            |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Artery, Necrosis, Fibrinoid          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                                    2                     |             
      Inflammation, Chronic                |                                                                          |             
      Subcutaneous Tissue, Edema           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |                                                                          |             
      Hyperostosis                         |                                     3     2  2                 2         |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                   +                    +                                 |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |          X                                                               |             
      Thalamus, Mineralization             | 1  1  2  2  1  3  3  3     2        2  3  3  1  2  2  3  2  2  2  1  1  2|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                     2                                    |             
      Edema                                |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                     3  2                 1               |             
      Infiltration Cellular, Histiocyte    |                   1                          3                           |             
      Inflammation, Chronic                |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Exudate                              |                                        X                                 |             
      Glands, Hyperplasia, Cystic          |                                        2                                1|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  10                                                               
NTP Experiment-Test: 05089-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 15:57:00  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 6| 6| 7| 7| 7| 0| 7| 5| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 5| 7|             
                             DAY ON TEST   | 5| 5| 5| 5| 5| 8| 8| 3| 3| 3| 1| 3| 1| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 1| 3|             
                                           | 5| 6| 7| 5| 6| 8| 1| 6| 6| 7| 6| 3| 0| 1| 3| 3| 6| 3| 6| 3| 3| 6| 6| 8| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 2| 2| 2| 2| 2| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                               ANIMAL ID   | 7| 7| 7| 7| 8| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8|             
    VEHICLE                                | 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    CONTROL                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                +         |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Casts Protein                        |                                              1     1  1           1     1|             
      Glomerulosclerosis                   |                                                                          |             
      Hydronephrosis                       |                                                                      4   |             
      Hyperplasia, Lymphoid                | 2  1  1  2        1     3        2  1  3                 3     1     3   |             
      Inflammation, Suppurative            |                                                                          |             
      Metaplasia, Osseous                  |                                                                          |             
      Mineralization                       |       1           1     1  1     1           1        1  1     1        1|             
      Papilla, Necrosis                    |                                                                          |             
      Renal Tubule, Atrophy                |                                                                      4   |             
      Renal Tubule, Dilatation             |                                                                      3   |             
      Renal Tubule, Necrosis               |                                                                          |             
      Renal Tubule, Regeneration           |    1  1     1     1     1  2     1  1     1  1        1  1  1  2     4  1|             
      Transitional Epithelium, Hyperplasia |                                                                      3   |             
                                            __________________________________________________________________________|             
   Ureter                                  |                                                                          |             
      Dilatation                           |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                                                      4   |             
      Hyperplasia, Lymphoid                | 1  1                 1  1  2     2        1  1  1        1        2  2   |             
      Inflammation, Subacute               |                                                                      3   |             
      Mucosa, Hyperplasia                  |                                                                      3   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  11                                                               
NTP Experiment-Test: 05089-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 15:57:00  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 4| 7| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 5| 3| 5| 5| 5| 5| 5|                                            |            |
                                           | 6| 6| 6| 2| 3| 7| 7| 8| 6| 8|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|                                            |      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 9| 9| 9| 9| 9| 0|                                            |      A     |
    VEHICLE                                | 6| 7| 8| 9| 0| 6| 7| 8| 9| 0|                                            |      L     |
    CONTROL                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  I  +  +  +  +  +  +  +                                             |  57        |
      Cyst                                 |                                                                          |      3     |
      Inflammation, Chronic                |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  57        |
      Edema                                |          2                                                               |      2  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +                                             |  57        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  58        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Artery, Jejunum, Necrosis, Fibrinoid |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  58        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Basophilic Focus                     |                                                                          |      2  3.5|
      Clear Cell Focus                     |                                                                          |      1     |
      Hematopoietic Cell Proliferation     |                                                                          |      5  1.6|
      Hemorrhage                           |                      1                                                   |      2  1.0|
      Hyperplasia, Focal                   | 2  2  2  3                                                               |     12  2.4|
      Hyperplasia, Lymphoid                |             1                                                            |      6  1.0|
      Infiltration Cellular, Mononuclear   |                                                                          |            |
          Cell                             |                                                                          |      1  1.0|
      Inflammation, Chronic                |                         1                                                |      2  1.0|
      Inflammation, Subacute               |                      1                                                   |      5  1.4|
      Mineralization                       |          3                                                               |      1  3.0|
      Mixed Cell Focus                     |                                                                          |      1     |
      Artery, Necrosis, Fibrinoid          |                                                                          |      1  4.0|
      Hepatocyte, Karyomegaly              |                                                                          |      1  2.0|
      Hepatocyte, Vacuolization Cytoplasmic|                                                                          |      3  1.7|
      Kupffer Cell, Hyperplasia            |                                                                          |      1  2.0|
      Kupffer Cell, Pigmentation           |                         1                                                |      2  2.0|
      Lobules, Necrosis                    |          2                                                               |      6  1.3|
                                            __________________________________________________________________________|____________|
   Mesentery                               | +     +  +                                                               |  17        |
      Edema                                |          3                                                               |      1  3.0|
      Artery, Necrosis, Fibrinoid          |                                                                          |      1  4.0|
      Fat, Inflammation, Suppurative       |          3                                                               |      1  3.0|
      Fat, Necrosis                        | 4     3  3                                                               |     14  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  12                                                               
NTP Experiment-Test: 05089-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 15:57:00  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 4| 7| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 5| 3| 5| 5| 5| 5| 5|                                            |            |
                                           | 6| 6| 6| 2| 3| 7| 7| 8| 6| 8|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|                                            |      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 9| 9| 9| 9| 9| 0|                                            |      A     |
    VEHICLE                                | 6| 7| 8| 9| 0| 6| 7| 8| 9| 0|                                            |      L     |
    CONTROL                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Atrophy                              |       1                                                                  |      3  1.3|
      Cytoplasmic Alteration               |                                                                          |      2  2.5|
      Focal Cellular Change                |                                                                          |      1     |
      Hyperplasia, Lymphoid                |                                                                          |      8  1.5|
      Inflammation, Subacute               |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Hyperplasia, Lymphoid                | 2                 1     1  1                                             |     24  1.8|
      Acinus, Hyperplasia, Cystic          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cyst                                 |                                                                          |      1     |
      Diverticulum                         |                                                                          |      1  3.0|
      Edema                                |                                                                          |      1  2.0|
      Inflammation, Suppurative            |                                                                          |      1  2.0|
      Ulcer                                |                                                                          |      1  1.0|
      Mucosa, Hyperplasia                  |          2                                                               |      2  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cyst                                 |       X              X  X                                                |     10     |
      Edema                                |                                                                          |      2  2.0|
      Erosion                              |                                                                          |      1  2.0|
      Inflammation, Subacute               |                                                                          |      3  2.0|
      Metaplasia, Squamous                 |                      2                                                   |      1  2.0|
      Mineralization                       |          3                                                               |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |          +                                                               |   2        |
      Necrosis, Fibrinoid                  |                                                                          |      1  4.0|
      Thrombosis                           |          X                                                               |      1     |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Myocardium, Inflammation, Subacute   |                                                                          |      1  3.0|
      Myocardium, Mineralization           |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Accessory Adrenal Cortical Nodule    | X  X  X                                                                  |     11     |
      Basophilic Focus                     |                                                                          |      3     |
      Clear Cell Focus                     |                                                                          |      1     |
      Hyperplasia, Focal                   |                                                                          |      3  1.7|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  13                                                               
NTP Experiment-Test: 05089-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 15:57:00  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 4| 7| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 5| 3| 5| 5| 5| 5| 5|                                            |            |
                                           | 6| 6| 6| 2| 3| 7| 7| 8| 6| 8|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|                                            |      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 9| 9| 9| 9| 9| 0|                                            |      A     |
    VEHICLE                                | 6| 7| 8| 9| 0| 6| 7| 8| 9| 0|                                            |      L     |
    CONTROL                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Capsule, Hyperplasia                 |          2                                                               |      3  1.7|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperplasia                          |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperplasia, Lymphoid                |                                                                          |      1  1.0|
      Hyperplasia                          |                                                                          |      3  2.3|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +                                             |  57        |
      Ectopic Thymus                       |                      X                                                   |      1     |
      Hyperplasia                          |             2                                                            |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Pars Distalis, Angiectasis           |                                                                          |      3  2.3|
      Pars Distalis, Hyperplasia           |    1        1                                                            |      9  1.4|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Degeneration, Cystic                 |       2  2                                                               |     26  1.7|
      Inflammation, Subacute               |       1                                                                  |      2  1.0|
      Follicle, Cyst                       |       X                                                                  |      3     |
      Follicular Cell, Hyperplasia         |             1                                                            |     12  1.2|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | I  +  +  +  +  +  +  +  +  +                                             |  56        |
      Angiectasis                          |                                                                          |     11  2.2|
      Cyst                                 |       X  X                 X                                             |     13     |
      Hyperplasia                          |             3                                                            |      1  3.0|
      Artery, Necrosis, Fibrinoid          |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Angiectasis                          |                                                                          |      5  2.4|
      Hydrometra                           |             2  3     3                                                   |     20  3.4|
      Hyperplasia, Cystic                  | 2  3  2  2  2  2  3  3  3  2                                             |     59  2.6|
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
      Inflammation, Suppurative            |                2  2        2                                             |      5  2.2|
      Metaplasia, Squamous                 |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hypercellularity                     |                                                                          |      7  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  14                                                               
NTP Experiment-Test: 05089-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 15:57:00  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 4| 7| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 5| 3| 5| 5| 5| 5| 5|                                            |            |
                                           | 6| 6| 6| 2| 3| 7| 7| 8| 6| 8|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|                                            |      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 9| 9| 9| 9| 9| 0|                                            |      A     |
    VEHICLE                                | 6| 7| 8| 9| 0| 6| 7| 8| 9| 0|                                            |      L     |
    CONTROL                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Artery, Necrosis, Fibrinoid          |                                                                          |      1  4.0|
      Iliac, Angiectasis                   |                                                                          |      2  4.0|
      Iliac, Hyperplasia, Plasma Cell      |                                                                          |      2  3.5|
      Renal, Hyperplasia, Plasma Cell      |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +                                             |  56        |
      Hyperplasia, Lymphoid                |                                                                          |      5  2.5|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Hematopoietic Cell Proliferation     |                                                                          |      2  2.0|
      Hemorrhage                           |                                                                          |      2  1.5|
      Hyperplasia, Lymphoid                |             2                                                            |      4  2.0|
      Hyperplasia, Plasma Cell             |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Hematopoietic Cell Proliferation     |       2  3  2                                                            |     21  2.4|
      Hemorrhage                           |          3                                                               |      1  3.0|
      Necrosis                             |          2                                                               |      1  2.0|
      Pigmentation, Hemosiderin            |                                                                          |      5  2.0|
      Lymphoid Follicle, Atrophy           |                                                                          |      1  2.0|
      Lymphoid Follicle, Hyperplasia       |    3                                                                     |      4  3.0|
      Red Pulp, Hyperplasia                |       3                                                                  |      3  2.7|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Angiectasis                          | 2  2                                                                     |      3  2.0|
      Cyst                                 |                                                                          |      9     |
      Depletion Cellular                   |                                                                          |      3  3.0|
      Ectopic Parathyroid Gland            |                                                                          |      1     |
      Hyperplasia, Lymphoid                |             4                                                            |      3  3.7|
      Artery, Necrosis, Fibrinoid          |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Acanthosis                           |                                                                          |      1  2.0|
      Inflammation, Chronic                |                         1                                                |      1  1.0|
      Subcutaneous Tissue, Edema           |          3                                                               |      2  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Fibrous Osteodystrophy               |          2                                                               |      1  2.0|
      Hyperostosis                         | 3                                                                        |      6  2.3|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   2        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  15                                                               
NTP Experiment-Test: 05089-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 15:57:00  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 4| 7| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 5| 3| 5| 5| 5| 5| 5|                                            |            |
                                           | 6| 6| 6| 2| 3| 7| 7| 8| 6| 8|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|                                            |      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 9| 9| 9| 9| 9| 0|                                            |      A     |
    VEHICLE                                | 6| 7| 8| 9| 0| 6| 7| 8| 9| 0|                                            |      L     |
    CONTROL                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Cyst                                 |                X                                                         |      2     |
      Thalamus, Mineralization             | 3  1  2  2        1        1                                             |     48  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Congestion                           |                                                                          |      2  2.0|
      Edema                                |          2                                                               |      1  2.0|
      Hemorrhage                           |          2                                                               |      2  2.0|
      Hyperplasia, Lymphoid                |             2                                                            |     10  1.6|
      Infiltration Cellular, Histiocyte    |          3                                                               |      3  2.3|
      Inflammation, Chronic                |                            3                                             |      1  3.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Exudate                              |             X                                                            |      3     |
      Glands, Hyperplasia, Cystic          |             2                                                            |      5  1.4|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Casts Protein                        |       1  2        1        1                                             |     14  1.2|
      Glomerulosclerosis                   |          2                                                               |      2  2.0|
      Hydronephrosis                       |                                                                          |      3  3.3|
      Hyperplasia, Lymphoid                |       1        2     2                                                   |     27  1.7|
      Inflammation, Suppurative            |                                                                          |      1  3.0|
      Metaplasia, Osseous                  |                                                                          |      1  3.0|
      Mineralization                       | 1  1     2  1  1  1                                                      |     25  1.2|
      Papilla, Necrosis                    |                                                                          |      1  4.0|
      Renal Tubule, Atrophy                |                                                                          |      4  2.5|
      Renal Tubule, Dilatation             |          3                                                               |      5  2.6|
      Renal Tubule, Necrosis               |                                                                          |      1  4.0|
      Renal Tubule, Regeneration           |    1  2  3  1  1  1  1  1                                                |     41  1.3|
      Transitional Epithelium, Hyperplasia |                                                                          |      2  3.5|
                                            __________________________________________________________________________|____________|
   Ureter                                  |                                                                          |   1        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  16                                                               
NTP Experiment-Test: 05089-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 15:57:00  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 4| 7| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 5| 3| 5| 5| 5| 5| 5|                                            |            |
                                           | 6| 6| 6| 2| 3| 7| 7| 8| 6| 8|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|                                            |      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 9| 9| 9| 9| 9| 0|                                            |      A     |
    VEHICLE                                | 6| 7| 8| 9| 0| 6| 7| 8| 9| 0|                                            |      L     |
    CONTROL                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Dilatation                           |                                                                          |      1  3.0|
      Inflammation, Suppurative            |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Dilatation                           |                                                                          |      1  4.0|
      Hyperplasia, Lymphoid                |    2  2     1        2                                                   |     26  1.5|
      Inflammation, Subacute               |                         3                                                |      3  3.0|
      Mucosa, Hyperplasia                  |                                                                          |      2  2.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  17                                                               
NTP Experiment-Test: 05089-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 15:57:00  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|                                            |            |
                             DAY ON TEST   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |            |
                                           | 7| 9| 8| 8| 7| 1| 0| 1| 2| 0|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 2| 2| 2| 2| 2| 7| 7| 7| 7| 7|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 9| 9| 9| 9| 9|                                            |      A     |
    VEHICLE                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |      L     |
    3 SSAC                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  M  +  +  +  +  +  +                                             |   9        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | M  +  +  M  +  +  +  +  +  +                                             |   8        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  M  +  +  +  +                                             |   9        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Inflammation, Acute                  |             1                                                            |      1  1.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Accessory Adrenal Cortical Nodule    |                         X                                                |      1     |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  M  +  +  +                                             |   9        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  M  +  +  +  +  +  +                                             |   9        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Hemorrhage                           |                            4                                             |      1  4.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  18                                                               
NTP Experiment-Test: 05089-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 15:57:00  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|                                            |            |
                             DAY ON TEST   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |            |
                                           | 7| 9| 8| 8| 7| 1| 0| 1| 2| 0|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 2| 2| 2| 2| 2| 7| 7| 7| 7| 7|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 9| 9| 9| 9| 9|                                            |      A     |
    VEHICLE                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |      L     |
    3 SSAC                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  M  +  +  +  +  +  +                                             |   9        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Hemorrhage                           |       2     1                                                            |      2  1.5|
      Inflammation, Chronic                |             1                                                            |      1  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Renal Tubule, Regeneration           |    1                 1                                                   |      2  1.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  19                                                               
NTP Experiment-Test: 05089-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 15:57:00  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 7| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 7| 7| 7| 7| 7| 7| 4| 3| 4| 4| 4| 9| 6| 6| 6| 8| 2| 6| 4| 4| 4| 4| 4| 4| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|             
    0.0200%                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                  1                                       |             
      Hyperplasia, Focal                   |                2        3                    2                           |             
      Hyperplasia, Lymphoid                |       1                                               1           1      |             
      Inflammation, Chronic                |             2                             1                              |             
      Inflammation, Subacute               |                         1                                                |             
      Mixed Cell Focus                     |                                                                          |             
      Kupffer Cell, Hyperplasia            |                                                                          |             
      Kupffer Cell, Pigmentation           |                                           3                              |             
      Lobules, Necrosis                    |                   1                                         2            |             
                                            __________________________________________________________________________|             
   Mesentery                               |                         +                                                |             
      Accessory Spleen                     |                                                                          |             
      Fat, Necrosis                        |                         4                                                |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                    2                     |             
      Cyst                                 |                                                                          |             
      Cytoplasmic Alteration               |                                  4                                       |             
      Hyperplasia, Lymphoid                |                                                    1                     |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |    3     2     1                          1                              |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Diverticulum                         |                2                                                         |             
      Edema                                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |       X  X                    X                             X            |             
      Inflammation, Subacute               |    3                                                                     |             
      Metaplasia, Squamous                 |                                                                          |             
      Mucosa, Hyperplasia                  |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                      +                                                   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                 +                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  20                                                               
NTP Experiment-Test: 05089-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 15:57:00  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 7| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 7| 7| 7| 7| 7| 7| 4| 3| 4| 4| 4| 9| 6| 6| 6| 8| 2| 6| 4| 4| 4| 4| 4| 4| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|             
    0.0200%                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Hypertrophy                          |                                                 2                        |             
      Inflammation, Chronic                |                                                 3                        |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |          X        X                 X           X        X           X  X|             
      Basophilic Focus                     |                   X                                                      |             
      Clear Cell Focus                     |                X                                                         |             
      Cyst                                 |                                                                          |             
      Hyperplasia, Focal                   |                                                                          |             
      Capsule, Hyperplasia                 |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                        1                          1      |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Ectopic Thymus                       |                                                                          |             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                                                                   2      |             
      Pars Distalis, Cyst                  |                                           X                              |             
      Pars Distalis, Hyperplasia           |                                     1                             1      |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 | 1  3                       1     1  1  2  1        2           1         |             
      Inflammation, Subacute               |                                                                          |             
      Follicle, Cyst                       |                                                                      X   |             
      Follicular Cell, Hyperplasia         |                                     1     2                    1     2  2|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  M  +  I  +  +  +  +  +|             
      Angiectasis                          |       2        2                 3        3                    2        2|             
      Cyst                                 | X        X  X  X           X  X  X  X  X              X                  |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |       2                          2                                       |             
      Hemorrhage                           |       2                                                                  |             
      Hydrometra                           |                                  3     3     4     3                     |             
      Hyperplasia, Cystic                  | 2  3  3  3  2  3  3     3  4  3  2  4  3  2  2  2  3  2  2  4  2  3  3  3|             
      Inflammation, Suppurative            |                                  3                                       |             
      Metaplasia, Squamous                 |                                                       1                  |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  21                                                               
NTP Experiment-Test: 05089-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 15:57:00  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 7| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 7| 7| 7| 7| 7| 7| 4| 3| 4| 4| 4| 9| 6| 6| 6| 8| 2| 6| 4| 4| 4| 4| 4| 4| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|             
    0.0200%                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hypercellularity                     |    X                             2                          2            |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Iliac, Hyperplasia, Lymphoid         |                                                                          |             
      Renal, Hyperplasia, Lymphoid         |                                                 3                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Hyperplasia, Plasma Cell             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +|             
      Hemorrhage                           |                                                                   3      |             
      Hyperplasia, Plasma Cell             |                2                                                         |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hematopoietic Cell Proliferation     |    3        2                    1  1  1  3        2        3            |             
      Pigmentation, Hemosiderin            |                                                                          |             
      Lymphoid Follicle, Hyperplasia       |                2                             2                           |             
      Red Pulp, Atrophy                    |                                                                          |             
      Red Pulp, Hyperplasia                |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M|             
      Angiectasis                          |       2                                                                  |             
      Cyst                                 |                   X                                                      |             
      Depletion Cellular                   |                      3           4                                       |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  |                                  1     2                                 |             
      Hyperplasia, Lobular                 |                                        1                                 |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                               1                                          |             
      Inflammation, Chronic                |                               1                                          |             
      Subcutaneous Tissue, Edema           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperostosis                         |                                                          2     4     2  1|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                                        X                                 |             
      Inflammation, Chronic                |                                                                      1   |             
      Thalamus, Mineralization             |       1                 1  2  1  2  2  2  2  3     1     1     2  2  2  2|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  22                                                               
NTP Experiment-Test: 05089-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 15:57:00  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 0| 7| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 7| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 7| 7| 7| 7| 7| 7| 4| 3| 4| 4| 4| 9| 6| 6| 6| 8| 2| 6| 4| 4| 4| 4| 4| 4| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|             
    0.0200%                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                      2                          3                        |             
      Hemorrhage                           |    2                                                                     |             
      Hyperplasia, Lymphoid                | 1     1        1                       1  2                       1      |             
      Infiltration Cellular, Histiocyte    |    4     1              1                    2                 1     1   |             
      Inflammation, Chronic                |                                                                          |             
      Leukocytosis                         |                                                 3                        |             
      Alveolar Epithelium, Hyperplasia     |          1                                                               |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Exudate                              |                                                                          |             
      Glands, Hyperplasia, Cystic          |                                                    1           1         |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |    +                                         +                           |             
      Cyst                                 |    X                                                                     |             
      Hyperplasia, Focal                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                      3                                                   |             
      Casts Protein                        | 1                 1                                1                     |             
      Cyst                                 |                                                                          |             
      Hemorrhage                           |                         3                          2                     |             
      Hyperplasia, Lymphoid                | 1     3  1     1                          1  1  1  1  2        1        1|             
      Metaplasia, Osseous                  |       1                                                                  |             
      Mineralization                       |    1                    2  1                             1     1     1   |             
      Renal Tubule, Atrophy                | 2  3  3                 3           1           3  2                    2|             
      Renal Tubule, Pigmentation           |                                                                          |             
      Renal Tubule, Regeneration           | 1  1     1     1  1     1              1           1        1  1     1  1|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                | 1     2        1  2        1  2     1  1  2  2  3  3  3     2  2     2   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  23                                                               
NTP Experiment-Test: 05089-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 15:57:00  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 5| 5| 5| 5| 5| 3| 3| 3| 3| 3| 3| 3| 6| 7| 3| 3| 3| 3| 3| 4| 3| 3| 3| 3| 3|             
                                           | 7| 5| 6| 7| 5| 8| 8| 8| 8| 8| 8| 7| 1| 5| 6| 6| 6| 7| 7| 7| 7| 7| 7| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|             
    0.0200%                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                        3                                 |             
      Hyperplasia, Focal                   |             1                 3  3     4           3                     |             
      Hyperplasia, Lymphoid                |                                                                2  2     2|             
      Inflammation, Chronic                |                      3                                                   |             
      Inflammation, Subacute               |          1     1                                                         |             
      Mixed Cell Focus                     |                                        X                                 |             
      Kupffer Cell, Hyperplasia            |                                        3                                3|             
      Kupffer Cell, Pigmentation           |                                                                          |             
      Lobules, Necrosis                    |    1                 1                          1                        |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                   +      |             
      Accessory Spleen                     |                                                                   X      |             
      Fat, Necrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                   1      |             
      Cyst                                 |                                  X                                       |             
      Cytoplasmic Alteration               |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                | 2                          1  2  2     3                             2   |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Diverticulum                         |                                                             3            |             
      Edema                                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |             X     X        X                                X        X   |             
      Inflammation, Subacute               |                                                                      2   |             
      Metaplasia, Squamous                 |                                                                2         |             
      Mucosa, Hyperplasia                  |                                                                      1   |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                   +      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  24                                                               
NTP Experiment-Test: 05089-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 15:57:00  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 5| 5| 5| 5| 5| 3| 3| 3| 3| 3| 3| 3| 6| 7| 3| 3| 3| 3| 3| 4| 3| 3| 3| 3| 3|             
                                           | 7| 5| 6| 7| 5| 8| 8| 8| 8| 8| 8| 7| 1| 5| 6| 6| 6| 7| 7| 7| 7| 7| 7| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|             
    0.0200%                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Hypertrophy                          |                                                                   3      |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |    X              X  X  X  X                       X        X  X        X|             
      Basophilic Focus                     |                                                                          |             
      Clear Cell Focus                     |                                                                          |             
      Cyst                                 |                         X                                                |             
      Hyperplasia, Focal                   |                                                                          |             
      Capsule, Hyperplasia                 |    2           2                                                         |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                        1                    1        1   |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ectopic Thymus                       |                                                                          |             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                                                                          |             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hyperplasia           |                      1  3                    2                       1   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 | 2  2                          1        2  1        2  1     1        1   |             
      Inflammation, Subacute               |                                                                2         |             
      Follicle, Cyst                       |                X                                            X            |             
      Follicular Cell, Hyperplasia         |                2     1                                      1           1|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                2  3           2              4  2     3        2  2      |             
      Cyst                                 |    X              X     X           X        X           X        X      |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                      4                                      2            |             
      Hemorrhage                           |                                                                          |             
      Hydrometra                           |                   3  3  4  3  3                 3              4         |             
      Hyperplasia, Cystic                  | 3  3  3  2  3  3  3  3  4  3  3  3  2     3  3  3  2  2     3  3  3  3  2|             
      Inflammation, Suppurative            |                                                       2  2               |             
      Metaplasia, Squamous                 |                   3        1                                             |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  25                                                               
NTP Experiment-Test: 05089-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 15:57:00  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 5| 5| 5| 5| 5| 3| 3| 3| 3| 3| 3| 3| 6| 7| 3| 3| 3| 3| 3| 4| 3| 3| 3| 3| 3|             
                                           | 7| 5| 6| 7| 5| 8| 8| 8| 8| 8| 8| 7| 1| 5| 6| 6| 6| 7| 7| 7| 7| 7| 7| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|             
    0.0200%                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hypercellularity                     |                                                       3                  |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Iliac, Hyperplasia, Lymphoid         |                                                                2         |             
      Renal, Hyperplasia, Lymphoid         |                                                                2         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Hyperplasia, Plasma Cell             |                                                                         2|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Plasma Cell             |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                   2      |             
      Hematopoietic Cell Proliferation     |                1  2  3                       1     3        2        1  2|             
      Pigmentation, Hemosiderin            |                                     2                                    |             
      Lymphoid Follicle, Hyperplasia       |          1                    3                             2     2      |             
      Red Pulp, Atrophy                    |                                                          2               |             
      Red Pulp, Hyperplasia                |                                           2                 2     2      |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  M  M  +  +  +  +  +  +  M  +  M  M  +  M  +  +  M  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Cyst                                 | X                                                                        |             
      Depletion Cellular                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  |                                                                          |             
      Hyperplasia, Lobular                 |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +|             
      Acanthosis                           |                      1                                                   |             
      Inflammation, Chronic                |                                                                          |             
      Subcutaneous Tissue, Edema           |                                        3                                 |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperostosis                         |                                                 2           3           3|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Thalamus, Mineralization             |    2  2  2  2  3  2  2  1  2  3  1  2     2  2              1  2  1  2  2|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  26                                                               
NTP Experiment-Test: 05089-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 15:57:00  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 5| 5| 5| 5| 5| 3| 3| 3| 3| 3| 3| 3| 6| 7| 3| 3| 3| 3| 3| 4| 3| 3| 3| 3| 3|             
                                           | 7| 5| 6| 7| 5| 8| 8| 8| 8| 8| 8| 7| 1| 5| 6| 6| 6| 7| 7| 7| 7| 7| 7| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2|             
    0.0200%                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                |                               2  1                 3        2           2|             
      Infiltration Cellular, Histiocyte    |                      2                             2                     |             
      Inflammation, Chronic                |       2                                                                  |             
      Leukocytosis                         |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Exudate                              |                X                                   X                     |             
      Glands, Hyperplasia, Cystic          |                2                                   1                     |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                            +                                             |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |             +                    +                          +            |             
      Cyst                                 |                                                                          |             
      Hyperplasia, Focal                   |                                                             3            |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                                                                          |             
      Casts Protein                        |                                                 1  1           1     1   |             
      Cyst                                 |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                | 1  1  1  1                 1     1     3        1              2         |             
      Metaplasia, Osseous                  |                                                                          |             
      Mineralization                       |                   1  1           1  2     1                              |             
      Renal Tubule, Atrophy                |                                                                          |             
      Renal Tubule, Pigmentation           |                                        4                                 |             
      Renal Tubule, Regeneration           | 1  1                 1  1     1  1  1     1  1  1           1  1        1|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                | 1     2     2        1  1     2        2        3  3     1           1   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  27                                                               
NTP Experiment-Test: 05089-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 15:57:00  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 7| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 3| 3| 9| 3| 3| 5| 5| 5| 5| 5|                                            |            |
                                           | 3| 3| 1| 3| 3| 6| 7| 6| 8| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|                                            |      A     |
    0.0200%                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Edema                                |                1                                                         |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +                                             |  57        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  57        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  58        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hematopoietic Cell Proliferation     |                                                                          |      2  2.0|
      Hyperplasia, Focal                   |    3                                                                     |      9  2.7|
      Hyperplasia, Lymphoid                | 1     1  3                                                               |      9  1.6|
      Inflammation, Chronic                |                                                                          |      3  2.0|
      Inflammation, Subacute               |                   1                                                      |      4  1.0|
      Mixed Cell Focus                     |                                                                          |      1     |
      Kupffer Cell, Hyperplasia            |                                                                          |      2  3.0|
      Kupffer Cell, Pigmentation           |                                                                          |      1  3.0|
      Lobules, Necrosis                    |                                                                          |      5  1.2|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   2        |
      Accessory Spleen                     |                                                                          |      1     |
      Fat, Necrosis                        |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Atrophy                              |                                                                          |      2  1.5|
      Cyst                                 |                                                                          |      1     |
      Cytoplasmic Alteration               |                                                                          |      1  4.0|
      Hyperplasia, Lymphoid                |             2                                                            |      2  1.5|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperplasia, Lymphoid                | 1  2  1  1  3  2     1  2  2                                             |     19  1.8|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  M  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  M  +  +  +  +  +                                             |  59        |
      Diverticulum                         |                                                                          |      2  2.5|
      Edema                                |                2                                                         |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  M  +  +  +  +  +                                             |  59        |
      Cyst                                 |                         X                                                |     10     |
      Inflammation, Subacute               |       2                                                                  |      3  2.3|
      Metaplasia, Squamous                 |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  28                                                               
NTP Experiment-Test: 05089-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 15:57:00  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 7| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 3| 3| 9| 3| 3| 5| 5| 5| 5| 5|                                            |            |
                                           | 3| 3| 1| 3| 3| 6| 7| 6| 8| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|                                            |      A     |
    0.0200%                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Mucosa, Hyperplasia                  |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   2        |
      Hypertrophy                          |                                                                          |      2  2.5|
      Inflammation, Chronic                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Accessory Adrenal Cortical Nodule    |                         X                                                |     17     |
      Basophilic Focus                     |                                                                          |      1     |
      Clear Cell Focus                     |                                                                          |      1     |
      Cyst                                 |          X                                                               |      2     |
      Hyperplasia, Focal                   |                1                                                         |      1  1.0|
      Capsule, Hyperplasia                 |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperplasia                          |                      1                                                   |      6  1.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Ectopic Thymus                       | X                                                                        |      1     |
      Pigmentation                         |                   2                                                      |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Pars Distalis, Angiectasis           |                                                                          |      1  2.0|
      Pars Distalis, Cyst                  |                                                                          |      1     |
      Pars Distalis, Hyperplasia           |             1                                                            |      7  1.4|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Degeneration, Cystic                 | 1                    2  2                                                |     21  1.5|
      Inflammation, Subacute               |                   1     1                                                |      3  1.3|
      Follicle, Cyst                       |                                                                          |      3     |
      Follicular Cell, Hyperplasia         |                                                                          |      9  1.4|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +                                             |  57        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  29                                                               
NTP Experiment-Test: 05089-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 15:57:00  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 7| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 3| 3| 9| 3| 3| 5| 5| 5| 5| 5|                                            |            |
                                           | 3| 3| 1| 3| 3| 6| 7| 6| 8| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|                                            |      A     |
    0.0200%                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Angiectasis                          |    2                                                                     |     15  2.4|
      Cyst                                 |          X        X     X                                                |     20     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Angiectasis                          |                                                                          |      4  2.5|
      Hemorrhage                           |                                                                          |      1  2.0|
      Hydrometra                           | 4  2  3                                                                  |     14  3.2|
      Hyperplasia, Cystic                  | 2  2     3  3  3  2  3  2  3                                             |     56  2.8|
      Inflammation, Suppurative            |                            2                                             |      4  2.3|
      Metaplasia, Squamous                 |                                                                          |      3  1.7|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hypercellularity                     |                                                                          |      4  2.3|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Iliac, Hyperplasia, Lymphoid         |                                                                          |      1  2.0|
      Renal, Hyperplasia, Lymphoid         |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperplasia, Lymphoid                |    3                                                                     |      1  3.0|
      Hyperplasia, Plasma Cell             |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  56        |
      Hemorrhage                           |                                                                          |      1  3.0|
      Hyperplasia, Plasma Cell             |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Congestion                           |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     | 3     2                                                                  |     18  2.0|
      Pigmentation, Hemosiderin            |                                                                          |      1  2.0|
      Lymphoid Follicle, Hyperplasia       | 3  3     3                                                               |      9  2.3|
      Red Pulp, Atrophy                    |                                                                          |      1  2.0|
      Red Pulp, Hyperplasia                |             2                                                            |      4  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +                                             |  51        |
      Angiectasis                          |                         3                                                |      2  2.5|
      Cyst                                 |                   X     X  X                                             |      5     |
      Depletion Cellular                   |                                                                          |      2  3.5|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperplasia, Cystic                  |                                                                          |      2  1.5|
      Hyperplasia, Lobular                 |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  58        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  30                                                               
NTP Experiment-Test: 05089-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 15:57:00  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 7| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 3| 3| 9| 3| 3| 5| 5| 5| 5| 5|                                            |            |
                                           | 3| 3| 1| 3| 3| 6| 7| 6| 8| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|                                            |      A     |
    0.0200%                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Acanthosis                           |                                                                          |      2  1.0|
      Inflammation, Chronic                |                                                                          |      1  1.0|
      Subcutaneous Tissue, Edema           |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperostosis                         |                                                                          |      7  2.4|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Compression                          |                                                                          |      1     |
      Inflammation, Chronic                |                                                                          |      1  1.0|
      Thalamus, Mineralization             | 2  1  2  1  2                                                            |     39  1.8|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Congestion                           |                                                                          |      2  2.5|
      Hemorrhage                           |       2                                                                  |      2  2.0|
      Hyperplasia, Lymphoid                |       1     2                                                            |     13  1.5|
      Infiltration Cellular, Histiocyte    |       1                                                                  |      9  1.7|
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Leukocytosis                         |                                                                          |      1  3.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Exudate                              |                                                                          |      2     |
      Glands, Hyperplasia, Cystic          |                                                                          |      4  1.3|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  59        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |             +                                                            |   6        |
      Cyst                                 |                                                                          |      1     |
      Hyperplasia, Focal                   |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Amyloid Deposition                   |                                                                          |      1  3.0|
      Casts Protein                        |                                                                          |      7  1.0|
      Cyst                                 |    X     X                                                               |      2     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  31                                                               
NTP Experiment-Test: 05089-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 15:57:00  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 7| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 3| 3| 9| 3| 3| 5| 5| 5| 5| 5|                                            |            |
                                           | 3| 3| 1| 3| 3| 6| 7| 6| 8| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|                                            |      A     |
    0.0200%                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Hemorrhage                           |                                                                          |      2  2.5|
      Hyperplasia, Lymphoid                | 2                       2  2                                             |     23  1.4|
      Metaplasia, Osseous                  |                                                                          |      1  1.0|
      Mineralization                       | 1  1                                                                     |     13  1.2|
      Renal Tubule, Atrophy                |                                                                          |      8  2.4|
      Renal Tubule, Pigmentation           |                                                                          |      1  4.0|
      Renal Tubule, Regeneration           |    1     1        1  1  1  1                                             |     31  1.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperplasia, Lymphoid                |    1  3     1  1  2  2  1  2                                             |     35  1.8|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  32                                                               
NTP Experiment-Test: 05089-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 15:57:00  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|                                            |            |
                             DAY ON TEST   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |            |
                                           | 7| 9| 8| 8| 7| 1| 2| 0| 1| 0|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 8| 8| 8| 8| 8|                                            |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 1| 2| 2| 2| 2| 3|                                            |      A     |
    0.0200%                                | 6| 7| 8| 9| 0| 6| 7| 8| 9| 0|                                            |      L     |
    3 SSAC                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  M  +  +  +  +                                             |   9        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Inflammation, Chronic                |                1  1     1  1                                             |      4  1.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Hyperplasia, Lymphoid                | 2                                                                        |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Accessory Adrenal Cortical Nodule    |                      X                                                   |      1     |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  M  +                                             |   9        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  M  +  +                                             |   9        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  M  +  +  +  +  M  +  +  +                                             |   8        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Inflammation, Suppurative            | 2                                                                        |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  33                                                               
NTP Experiment-Test: 05089-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 15:57:00  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|                                            |            |
                             DAY ON TEST   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |            |
                                           | 7| 9| 8| 8| 7| 1| 2| 0| 1| 0|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 8| 8| 8| 8| 8|                                            |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 1| 2| 2| 2| 2| 3|                                            |      A     |
    0.0200%                                | 6| 7| 8| 9| 0| 6| 7| 8| 9| 0|                                            |      L     |
    3 SSAC                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Endometrium, Cyst                    | 2  1                    1                                                |      3  1.3|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Renal Tubule, Regeneration           |             1        1     1                                             |      3  1.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  34                                                               
NTP Experiment-Test: 05089-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 15:57:00  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 6| 7| 7| 7| 3| 5| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 2| 0| 3| 7| 6| 3| 3| 3| 8| 0| 3| 3| 2| 3| 3|             
                                           | 7| 7| 1| 7| 7| 7| 3| 3| 3| 3| 8| 9| 5| 9| 9| 5| 5| 5| 5| 9| 3| 3| 8| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|             
    0.0100%                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                                       3                  |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     |    X  3                                                                 X|             
      Clear Cell Focus                     |                                           X                              |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Focal                   |    3                       2                                             |             
      Hyperplasia, Lymphoid                |                2                    1                                    |             
      Inflammation, Chronic                |                                                       1                  |             
      Inflammation, Subacute               |             2  3                          1                              |             
      Hepatocyte, Vacuolization Cytoplasmic|       2                                                                  |             
      Kupffer Cell, Hyperplasia            |             2                                                            |             
      Lobules, Necrosis                    | 1     4     1                          2                 2               |             
                                            __________________________________________________________________________|             
   Mesentery                               |    +     +                             +                                 |             
      Fat, Necrosis                        |    3     3                                                               |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Cyst                                 |                                     X                                    |             
      Cytoplasmic Alteration               |                                  4        4              4        4      |             
      Focal Cellular Change                |                                                    X                     |             
      Hyperplasia, Lymphoid                |                                              2        2     1            |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                | 1              2     2  3  1        1        3  1  1  2     1  1     1   |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Subacute               |                               1                                          |             
      Inflammation, Suppurative            |       1                                                                  |             
      Mucosa, Hyperplasia                  |       1           1                                                      |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |    X     X                                                           X   |             
      Edema                                |                                                                          |             
      Erosion                              |                                                          3               |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  35                                                               
NTP Experiment-Test: 05089-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 15:57:00  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 6| 7| 7| 7| 3| 5| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 2| 0| 3| 7| 6| 3| 3| 3| 8| 0| 3| 3| 2| 3| 3|             
                                           | 7| 7| 1| 7| 7| 7| 3| 3| 3| 3| 8| 9| 5| 9| 9| 5| 5| 5| 5| 9| 3| 3| 8| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|             
    0.0100%                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Myocardium, Inflammation, Chronic    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                   X     X           X                 X                  |             
      Basophilic Focus                     |                                                                         X|             
      Cyst                                 |                                                                          |             
      Hyperplasia, Focal                   |       2                    1                    3                        |             
      Capsule, Hyperplasia                 |                                                                          |             
      X-Zone, Degeneration, Fatty          |             3                                                            |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Hyperplasia                          |                            3           2                 2  1            |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                              X                           |             
      Ectopic Thymus                       |                X  X                                                      |             
      Hyperplasia                          |          1                                                               |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |          1                                                               |             
      Pars Distalis, Cyst                  |                X                                                         |             
      Pars Distalis, Hyperplasia           |          2                                                           1   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 |       1        1     2           2              1     1  1  2        2   |             
      Ectopic Thymus                       |                                              X                           |             
      Inflammation, Subacute               |                                                                1         |             
      Follicle, Cyst                       |                                                                          |             
      Follicular Cell, Hyperplasia, Diffuse|             4                                                            |             
      Follicular Cell, Hyperplasia, Focal  |                                           3                              |             
      Follicular Cell, Hyperplasia         | 1  1                       3                    4                        |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Angiectasis                          | 2     4     2              2     2                                   2   |             
      Cyst                                 |                X     X  X     X     X     X  X  X        X     X         |             
      Interstitial Cell, Hyperplasia       |                                              3                           |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  36                                                               
NTP Experiment-Test: 05089-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 15:57:00  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 6| 7| 7| 7| 3| 5| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 2| 0| 3| 7| 6| 3| 3| 3| 8| 0| 3| 3| 2| 3| 3|             
                                           | 7| 7| 1| 7| 7| 7| 3| 3| 3| 3| 8| 9| 5| 9| 9| 5| 5| 5| 5| 9| 3| 3| 8| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|             
    0.0100%                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Angiectasis                          |          4                                         2                     |             
      Granuloma                            |                                                             2            |             
      Hydrometra                           |             3              2           3                 3     4  3      |             
      Hyperplasia, Cystic                  | 1  4  3  3  3  2  2  3  3  3  3  1  3  2  3  2  2  3     2  3  2  2  3  1|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Inflammation, Suppurative            | 1                                                        2               |             
      Metaplasia, Squamous                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hypercellularity                     |       2                                                                  |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  I|             
      Hemorrhage                           |                            4                                             |             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     | 3  2  4  3        1           2  3           1              1  2         |             
      Hemorrhage                           |                                                                          |             
      Pigmentation, Hemosiderin            |             2                                                            |             
      Lymphoid Follicle, Hyperplasia       |                            2                    2     3                  |             
      Red Pulp, Hyperplasia                |             1                                               3            |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Angiectasis                          |                               2                                          |             
      Cyst                                 |    X                          X                                          |             
      Depletion Cellular                   |       3                                                  4               |             
      Ectopic Parathyroid Gland            |                                                                          |             
      Hyperplasia, Lymphoid                |                                                 3                        |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  |                                     1                                    |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperostosis                         |    2     1           1              1                                    |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |             X                                                            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  37                                                               
NTP Experiment-Test: 05089-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 15:57:00  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 6| 6| 7| 7| 7| 3| 5| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 3| 3| 7| 3| 3| 3| 3| 3| 3| 3| 2| 0| 3| 7| 6| 3| 3| 3| 8| 0| 3| 3| 2| 3| 3|             
                                           | 7| 7| 1| 7| 7| 7| 3| 3| 3| 3| 8| 9| 5| 9| 9| 5| 5| 5| 5| 9| 3| 3| 8| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4|             
    0.0100%                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Hydrocephalus                        |             2                                                            |             
      Thalamus, Mineralization             |          1  1  3  2  2     2  2  1        1  1  3  2           1  1  2  1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                  2        3           2  2        3      |             
      Hemorrhage                           |          2              2                                                |             
      Hyperplasia, Lymphoid                | 1        1     2  2                          2                 1        2|             
      Infiltration Cellular, Histiocyte    |                                                       1     2            |             
      Leukocytosis                         |                                  3                                       |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Glands, Hyperplasia, Cystic          |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Casts Protein                        | 1                             2                                          |             
      Cyst                                 |                                                                         X|             
      Hemorrhage                           |                                                    2                     |             
      Hyperplasia, Lymphoid                |                1                 1           2  1     2                  |             
      Metaplasia, Osseous                  |       2                                      1                           |             
      Mineralization                       |       2                                            1  2     1            |             
      Thrombosis                           |                                                                          |             
      Interstitium, Pigmentation           |       3                                                                  |             
      Renal Tubule, Atrophy                |    2  2                                                                  |             
      Renal Tubule, Casts Protein          |                                                                          |             
      Renal Tubule, Dilatation             | 2     2     2                 2                                   2      |             
      Renal Tubule, Necrosis               |       3                                                                  |             
      Renal Tubule, Pigmentation           |       3                                                                  |             
      Renal Tubule, Regeneration           | 2  1  3  1     1  2     1  1  3           1  1     1        1           1|             
      Transitional Epithelium, Hyperplasia |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                               2                                          |             
      Hyperplasia, Lymphoid                | 2  2  1  3  1     1  2     1  2              2  1           1        2   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  38                                                               
NTP Experiment-Test: 05089-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 15:57:00  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 5| 5| 5| 5| 5| 3| 3| 3| 3| 3| 2| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 6| 5| 7| 6| 5| 7| 7| 7| 1| 7| 1| 2| 8| 6| 6| 6| 6| 8| 8| 6| 8| 0| 8| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
                               ANIMAL ID   | 4| 4| 4| 4| 5| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|             
    0.0100%                                | 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |                +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |                +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |                +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                         3                                                |             
      Basophilic Focus                     |                         X                                3        X      |             
      Clear Cell Focus                     |                                                                          |             
      Hemorrhage                           |                1                                                         |             
      Hyperplasia, Focal                   |                      2  3  2                          3  2        3      |             
      Hyperplasia, Lymphoid                |                                                    1              3      |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Subacute               |                                     1           1        1               |             
      Hepatocyte, Vacuolization Cytoplasmic|                                                                          |             
      Kupffer Cell, Hyperplasia            |                                                                          |             
      Lobules, Necrosis                    |                      1  4           2  1                                 |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                        +        +     +                 +|             
      Fat, Necrosis                        |                                        4        4     2                 4|             
                                            __________________________________________________________________________|             
   Pancreas                                |                +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                              2                           |             
      Cyst                                 |                                                                          |             
      Cytoplasmic Alteration               |                               3                                          |             
      Focal Cellular Change                |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                   2  4   |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                1  1     2     1           1     2  1     2     1         |             
                                            __________________________________________________________________________|             
   Stomach                                 |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Subacute               |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Mucosa, Hyperplasia                  |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                 X        X  X            |             
      Edema                                |                         2                                                |             
      Erosion                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  39                                                               
NTP Experiment-Test: 05089-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 15:57:00  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 5| 5| 5| 5| 5| 3| 3| 3| 3| 3| 2| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 6| 5| 7| 6| 5| 7| 7| 7| 1| 7| 1| 2| 8| 6| 6| 6| 6| 8| 8| 6| 8| 0| 8| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
                               ANIMAL ID   | 4| 4| 4| 4| 5| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|             
    0.0100%                                | 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Myocardium, Inflammation, Chronic    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                      X     X                       X                     |             
      Basophilic Focus                     |                                                                          |             
      Cyst                                 |                                                                          |             
      Hyperplasia, Focal                   |                         1                                2               |             
      Capsule, Hyperplasia                 |                                                 2                        |             
      X-Zone, Degeneration, Fatty          |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                   1                          1                           |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |                +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +|             
      Cyst                                 |                            X                                             |             
      Hyperplasia, Lymphoid                |                                                                      3   |             
      Hyperplasia                          |                                              2     1                     |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |                +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Ectopic Thymus                       |                                                                          |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                1                                                  1     1|             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hyperplasia           |                1        1                                               2|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 |                2  2  3              1        1  1  2  2  2     2  1  1   |             
      Ectopic Thymus                       |                                                                          |             
      Inflammation, Subacute               |                                                                          |             
      Follicle, Cyst                       |                                                       X                  |             
      Follicular Cell, Hyperplasia, Diffuse|                                                                          |             
      Follicular Cell, Hyperplasia, Focal  |                                                                          |             
      Follicular Cell, Hyperplasia         |                1           1           2                          1      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                      3           2                          3  2         |             
      Cyst                                 |                                  X                       X        X  X   |             
      Interstitial Cell, Hyperplasia       |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  40                                                               
NTP Experiment-Test: 05089-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 15:57:00  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 5| 5| 5| 5| 5| 3| 3| 3| 3| 3| 2| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 6| 5| 7| 6| 5| 7| 7| 7| 1| 7| 1| 2| 8| 6| 6| 6| 6| 8| 8| 6| 8| 0| 8| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
                               ANIMAL ID   | 4| 4| 4| 4| 5| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|             
    0.0100%                                | 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Angiectasis                          |                      2        4     4                                    |             
      Granuloma                            |                                                                          |             
      Hydrometra                           |       2     2  4                 4     4     4  4        3     4  3      |             
      Hyperplasia, Cystic                  | 2  3     2  3  3  3  3  3  2  2  3  3  2  2        3  3  3  3     2  2  3|             
      Hyperplasia, Lymphoid                |                1                                   2                     |             
      Inflammation, Suppurative            |                                                                          |             
      Metaplasia, Squamous                 |                                                                      2   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hypercellularity                     |                                                 2                        |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |                +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                                 2                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                        2                                 |             
                                            __________________________________________________________________________|             
   Spleen                                  |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                 2     1                  |             
      Hemorrhage                           |                                                                          |             
      Pigmentation, Hemosiderin            |                                                                          |             
      Lymphoid Follicle, Hyperplasia       |                            2                                      3      |             
      Red Pulp, Hyperplasia                |                         2                                                |             
                                            __________________________________________________________________________|             
   Thymus                                  |                +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                   3      |             
      Cyst                                 |                         X        X                                       |             
      Depletion Cellular                   |                               3                                          |             
      Ectopic Parathyroid Gland            |                                                                      X   |             
      Hyperplasia, Lymphoid                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  |                               1                                          |             
                                            __________________________________________________________________________|             
   Skin                                    |                +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                  1                                       |             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperostosis                         |                                  4        3           3                  |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  41                                                               
NTP Experiment-Test: 05089-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 15:57:00  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 5| 5| 5| 5| 5| 3| 3| 3| 3| 3| 2| 3| 8| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 6| 5| 7| 6| 5| 7| 7| 7| 1| 7| 1| 2| 8| 6| 6| 6| 6| 8| 8| 6| 8| 0| 8| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
                               ANIMAL ID   | 4| 4| 4| 4| 5| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5|             
    0.0100%                                | 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Hydrocephalus                        |                                                                          |             
      Thalamus, Mineralization             |                2     3  1  3  1  2     2  2  2  2  1  2                 2|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                |                2  1     1                    1                           |             
      Infiltration Cellular, Histiocyte    |                                                                          |             
      Leukocytosis                         |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Glands, Hyperplasia, Cystic          |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                +                                                         |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Casts Protein                        |                               1                                   1  1   |             
      Cyst                                 |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                |                1  2  1  2                    1           1        1  4   |             
      Metaplasia, Osseous                  |                                                                      3  1|             
      Mineralization                       |                      2              1  1                       2         |             
      Thrombosis                           |                                                                      X   |             
      Interstitium, Pigmentation           |                                                                          |             
      Renal Tubule, Atrophy                |                   2     1                                            4   |             
      Renal Tubule, Casts Protein          |             1                                                            |             
      Renal Tubule, Dilatation             |                                                                          |             
      Renal Tubule, Necrosis               |                                                                          |             
      Renal Tubule, Pigmentation           |                                                                          |             
      Renal Tubule, Regeneration           | 1  1     1  1  1  1  1  1  1     1  1  2  1  1        1  1  1  1  1  1   |             
      Transitional Epithelium, Hyperplasia |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |                +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Hyperplasia, Lymphoid                |                2  1     3        1     1  1     1  1     2  2  1        3|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  42                                                               
NTP Experiment-Test: 05089-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 15:57:00  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 7| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 3| 3| 8| 3| 3| 5| 5| 5| 5| 5|                                            |            |
                                           | 2| 3| 1| 3| 3| 6| 7| 6| 8| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 6| 6| 6| 6| 6| 7|                                            |      A     |
    0.0100%                                | 6| 7| 8| 9| 0| 6| 7| 8| 9| 0|                                            |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +                                                            |  48        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +                                                            |  48        |
      Dilatation                           |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +                                                            |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +                                                            |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +                                                            |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +                                                            |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +                                                            |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +                                                            |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +                                                            |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +                                                            |  49        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +                                                            |  50        |
      Angiectasis                          |                                                                          |      1  3.0|
      Basophilic Focus                     | X                                                                        |      7  3.0|
      Clear Cell Focus                     |                                                                          |      1     |
      Hemorrhage                           |                                                                          |      1  1.0|
      Hyperplasia, Focal                   | 3                                                                        |      9  2.6|
      Hyperplasia, Lymphoid                |                                                                          |      4  1.8|
      Inflammation, Chronic                |                                                                          |      1  1.0|
      Inflammation, Subacute               |             1                                                            |      7  1.4|
      Hepatocyte, Vacuolization Cytoplasmic|                                                                          |      1  2.0|
      Kupffer Cell, Hyperplasia            |                                                                          |      1  2.0|
      Lobules, Necrosis                    |       2                                                                  |     10  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |       +                                                                  |   8        |
      Fat, Necrosis                        |                                                                          |      6  3.3|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +                                                            |  49        |
      Atrophy                              |             3                                                            |      2  2.5|
      Cyst                                 |                                                                          |      1     |
      Cytoplasmic Alteration               |                                                                          |      5  3.8|
      Focal Cellular Change                |                                                                          |      1     |
      Hyperplasia, Lymphoid                |                                                                          |      5  2.2|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +                                                            |  50        |
      Hyperplasia, Lymphoid                |                                                                          |     22  1.5|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +                                                            |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +                                                            |  50        |
      Inflammation, Subacute               |                                                                          |      1  1.0|
      Inflammation, Suppurative            |                                                                          |      1  1.0|
      Mucosa, Hyperplasia                  |                                                                          |      2  1.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +                                                            |  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  43                                                               
NTP Experiment-Test: 05089-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 15:57:00  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 7| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 3| 3| 8| 3| 3| 5| 5| 5| 5| 5|                                            |            |
                                           | 2| 3| 1| 3| 3| 6| 7| 6| 8| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 6| 6| 6| 6| 6| 7|                                            |      A     |
    0.0100%                                | 6| 7| 8| 9| 0| 6| 7| 8| 9| 0|                                            |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Cyst                                 |       X                                                                  |      7     |
      Edema                                |                                                                          |      1  2.0|
      Erosion                              |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +                                                            |  50        |
      Myocardium, Inflammation, Chronic    | 2                                                                        |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +                                                            |  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +                                                            |  50        |
      Accessory Adrenal Cortical Nodule    |          X  X                                                            |      9     |
      Basophilic Focus                     |                                                                          |      1     |
      Cyst                                 |       X                                                                  |      1     |
      Hyperplasia, Focal                   |                                                                          |      5  1.8|
      Capsule, Hyperplasia                 |                                                                          |      1  2.0|
      X-Zone, Degeneration, Fatty          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +                                                            |  50        |
      Hyperplasia                          |                                                                          |      2  1.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +                                                            |  48        |
      Cyst                                 |                                                                          |      1     |
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
      Hyperplasia                          |                                                                          |      6  1.8|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +                                                            |  49        |
      Cyst                                 |                                                                          |      1     |
      Ectopic Thymus                       |                                                                          |      2     |
      Hyperplasia                          |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +                                                            |  47        |
      Pars Distalis, Angiectasis           |                                                                          |      4  1.0|
      Pars Distalis, Cyst                  | X                                                                        |      2     |
      Pars Distalis, Hyperplasia           | 1  1                                                                     |      7  1.3|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +                                                            |  50        |
      Degeneration, Cystic                 |    1  2                                                                  |     23  1.6|
      Ectopic Thymus                       |                                                                          |      1     |
      Inflammation, Subacute               |    1     1                                                               |      3  1.0|
      Follicle, Cyst                       |                                                                          |      1     |
      Follicular Cell, Hyperplasia, Diffuse|                                                                          |      1  4.0|
      Follicular Cell, Hyperplasia, Focal  |                                                                          |      1  3.0|
      Follicular Cell, Hyperplasia         | 2           1                                                            |     10  1.7|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  44                                                               
NTP Experiment-Test: 05089-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 15:57:00  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 7| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 3| 3| 8| 3| 3| 5| 5| 5| 5| 5|                                            |            |
                                           | 2| 3| 1| 3| 3| 6| 7| 6| 8| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 6| 6| 6| 6| 6| 7|                                            |      A     |
    0.0100%                                | 6| 7| 8| 9| 0| 6| 7| 8| 9| 0|                                            |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  M  +  +  +                                                            |  48        |
      Angiectasis                          |                                                                          |     10  2.4|
      Cyst                                 | X        X  X                                                            |     17     |
      Interstitial Cell, Hyperplasia       |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +     +  +                                             |  59        |
      Angiectasis                          |                                                                          |      5  3.2|
      Granuloma                            |                                                                          |      1  2.0|
      Hydrometra                           | 4     4                                                                  |     18  3.3|
      Hyperplasia, Cystic                  | 3  1  3  2  2  2  2     3  2                                             |     54  2.5|
      Hyperplasia, Lymphoid                |                                                                          |      2  1.5|
      Inflammation, Suppurative            |          1                                                               |      3  1.3|
      Metaplasia, Squamous                 |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +                                                            |  50        |
      Hypercellularity                     |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +                                                            |  50        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +                                                            |  47        |
      Hemorrhage                           |                                                                          |      1  4.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +                                                            |  48        |
      Hemorrhage                           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +                                                            |  50        |
      Hematopoietic Cell Proliferation     |          1                                                               |     13  2.0|
      Hemorrhage                           |       4                                                                  |      1  4.0|
      Pigmentation, Hemosiderin            |                                                                          |      1  2.0|
      Lymphoid Follicle, Hyperplasia       |                                                                          |      5  2.4|
      Red Pulp, Hyperplasia                |                                                                          |      3  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  M  +                                                            |  47        |
      Angiectasis                          |                                                                          |      2  2.5|
      Cyst                                 |                                                                          |      4     |
      Depletion Cellular                   |                                                                          |      3  3.3|
      Ectopic Parathyroid Gland            |                                                                          |      1     |
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  45                                                               
NTP Experiment-Test: 05089-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 15:57:00  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 7| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 3| 3| 8| 3| 3| 5| 5| 5| 5| 5|                                            |            |
                                           | 2| 3| 1| 3| 3| 6| 7| 6| 8| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 6| 6| 6| 6| 6| 7|                                            |      A     |
    0.0100%                                | 6| 7| 8| 9| 0| 6| 7| 8| 9| 0|                                            |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +                                                            |  49        |
      Hyperplasia, Cystic                  |                                                                          |      2  1.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +                                                            |  49        |
      Acanthosis                           | 1                                                                        |      2  1.0|
      Inflammation, Chronic                | 1                                                                        |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +                                                            |  50        |
      Hyperostosis                         |                                                                          |      7  2.1|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +                                                            |  50        |
      Compression                          |                                                                          |      1     |
      Hydrocephalus                        |                                                                          |      1  2.0|
      Thalamus, Mineralization             | 2  2  2  2                                                               |     33  1.8|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +                                                            |  50        |
      Congestion                           |                                                                          |      5  2.4|
      Hemorrhage                           |                                                                          |      2  2.0|
      Hyperplasia, Lymphoid                | 1                                                                        |     12  1.4|
      Infiltration Cellular, Histiocyte    |                                                                          |      2  1.5|
      Leukocytosis                         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +                                                            |  50        |
      Glands, Hyperplasia, Cystic          | 1                                                                        |      1  1.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +                                                            |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +                                                   |  57        |
      Casts Protein                        |       1                                                                  |      6  1.2|
      Cyst                                 |                                                                          |      1     |
      Hemorrhage                           |                                                                          |      1  2.0|
      Hyperplasia, Lymphoid                | 1        1                                                               |     15  1.5|
      Metaplasia, Osseous                  |                                                                          |      4  1.8|
      Mineralization                       |                                                                          |      8  1.5|
      Thrombosis                           |                                                                          |      1     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  46                                                               
NTP Experiment-Test: 05089-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 15:57:00  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 7| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 3| 3| 8| 3| 3| 5| 5| 5| 5| 5|                                            |            |
                                           | 2| 3| 1| 3| 3| 6| 7| 6| 8| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 6| 6| 6| 6| 6| 7|                                            |      A     |
    0.0100%                                | 6| 7| 8| 9| 0| 6| 7| 8| 9| 0|                                            |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Interstitium, Pigmentation           |                                                                          |      1  3.0|
      Renal Tubule, Atrophy                |             1                                                            |      6  2.0|
      Renal Tubule, Casts Protein          |                                                                          |      1  1.0|
      Renal Tubule, Dilatation             |       2                                                                  |      6  2.0|
      Renal Tubule, Necrosis               |                                                                          |      1  3.0|
      Renal Tubule, Pigmentation           |                                                                          |      1  3.0|
      Renal Tubule, Regeneration           | 2  1  1  1  1  1  1  2                                                   |     42  1.2|
      Transitional Epithelium, Hyperplasia | 3                                                                        |      1  3.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +                                                            |  49        |
      Angiectasis                          |                                                                          |      1  2.0|
      Hyperplasia, Lymphoid                |    1     2                                                               |     27  1.6|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  47                                                               
NTP Experiment-Test: 05089-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 15:57:00  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|                                            |            |
                             DAY ON TEST   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |            |
                                           | 9| 7| 8| 9| 7| 1| 0| 2| 1| 2|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 8| 8| 8| 8| 8|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 6| 6| 6| 6| 6|                                            |      A     |
    0.0100%                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |      L     |
    3 SSAC                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Uterus                                  |             +  +  +        +                                             |   4        |
      Endometrium, Cyst                    |             1  1  1        1                                             |      4  1.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  48                                                               
NTP Experiment-Test: 05089-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 15:57:00  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 5| 7| 7| 7| 7| 7| 6| 7| 5| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 7| 3| 7| 3| 3| 3| 3| 3| 2| 3| 9| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3|             
                                           | 2| 6| 9| 6| 6| 6| 3| 3| 8| 3| 0| 3| 7| 2| 7| 7| 7| 7| 3| 3| 3| 3| 6| 3| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    0.00500%                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                                                          |             
      Clear Cell Focus                     |                X                                                         |             
      Hematopoietic Cell Proliferation     |                                                    3                     |             
      Hyperplasia, Focal                   |                2  3                                2     3        3      |             
      Hyperplasia, Lymphoid                |                      1              1                                    |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Subacute               |                                        1                                 |             
      Centrilobular, Necrosis              |                                                                          |             
      Hepatocyte, Karyomegaly              |                                                                          |             
      Hepatocyte, Vacuolization Cytoplasmic|             2                    2                                       |             
      Kupffer Cell, Hyperplasia            |                                                                          |             
      Lobules, Necrosis                    |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                         +  +           +                             +   |             
      Fat, Necrosis                        |                         1              2                             2   |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                       2                  |             
      Cytoplasmic Alteration               | 3                                            2                           |             
      Hyperplasia, Lymphoid                |    1              1              1  2  1              1     3           3|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |       2     2        1              1  1              1  1  2        1  2|             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                | 2                                                                        |             
      Fibrosis                             |                                                                1         |             
      Mucosa, Hyperplasia                  | 2                                                                    1   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                X                          X           X                  |             
      Edema                                |                                                                          |             
      Inflammation, Subacute               |                                                                          |             
      Mucosa, Hyperplasia                  |                                                       1                  |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  49                                                               
NTP Experiment-Test: 05089-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 15:57:00  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 5| 7| 7| 7| 7| 7| 6| 7| 5| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 7| 3| 7| 3| 3| 3| 3| 3| 2| 3| 9| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3|             
                                           | 2| 6| 9| 6| 6| 6| 3| 3| 8| 3| 0| 3| 7| 2| 7| 7| 7| 7| 3| 3| 3| 3| 6| 3| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    0.00500%                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |          X              X                 X  X           X               |             
      Cyst                                 |                                                                          |             
      X-Zone, Degeneration, Fatty          |    1                                                                     |             
      Zona Reticularis, Proliferation      |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                            1                                             |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                      2              3  1                                1|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                            2                                             |             
      Pars Distalis, Cyst                  |                                           X                              |             
      Pars Distalis, Hyperplasia, Focal    |                                           4                              |             
      Pars Distalis, Hyperplasia           |    2                    2  2                                             |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 |          2  1  1     1     1     1  2  1  1  1        1  1     1  1      |             
      Hyperplasia, Lymphoid                |                                     1                                    |             
      Inflammation, Subacute               |                                                    2                     |             
      Follicular Cell, Hyperplasia         |                   1                       1     1  2              1      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |                                                          +               |             
      Ectasia                              |                                                          2               |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I|             
      Angiectasis                          | 2                          2           3  1     2  4  2              2   |             
      Cyst                                 |                         X           X                 X        X         |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                4                                                         |             
      Hydrometra                           |    3     3              3           3           3                        |             
      Hyperplasia, Cystic                  | 3  3  2  2  3  2  2  1  2  2  2  2  2  3  2  2  3  2  2  2  2  2  2  3  3|             
      Hyperplasia, Lymphoid                |          2                                                               |             
      Inflammation, Suppurative            |                         2                                                |             
      Metaplasia, Squamous                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  50                                                               
NTP Experiment-Test: 05089-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 15:57:00  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 5| 7| 7| 7| 7| 7| 6| 7| 5| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 7| 3| 7| 3| 3| 3| 3| 3| 2| 3| 9| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3|             
                                           | 2| 6| 9| 6| 6| 6| 3| 3| 8| 3| 0| 3| 7| 2| 7| 7| 7| 7| 3| 3| 3| 3| 6| 3| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    0.00500%                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hypercellularity                     |             2                                      2                     |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Iliac, Hyperplasia, Lymphoid         |                                                                          |             
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                     3                             4      |             
      Hyperplasia, Plasma Cell             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Depletion Cellular                   |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hemorrhage                           |                               1                                          |             
      Hyperplasia, Lymphoid                |    4                                                  3                  |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Hematopoietic Cell Proliferation     |       3     3              2  4        3           4              2      |             
      Pigmentation, Hemosiderin            | 2  2                                                                     |             
      Lymphoid Follicle, Atrophy           |                                                                          |             
      Lymphoid Follicle, Hyperplasia       |                   2                                   2                 2|             
      Red Pulp, Atrophy                    | 2                                                                        |             
      Red Pulp, Hyperplasia                |                                                             2           3|             
                                            __________________________________________________________________________|             
   Thymus                                  | I  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Cyst                                 |       X           X     X              X  X                       X      |             
      Depletion Cellular                   |    2                                         2                           |             
      Ectopic Parathyroid Gland            |                      X                                                   |             
      Hyperplasia, Lymphoid                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lobular                 |                                              1                           |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                                                          |             
      Inflammation, Chronic, Focal         |                                                                          |             
      Ulcer                                |                                                                   4      |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperostosis                         |                3                 1  2     2     1                        |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                                                                          |             
      Necrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  51                                                               
NTP Experiment-Test: 05089-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 15:57:00  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 5| 7| 7| 7| 7| 7| 6| 7| 5| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 7| 3| 7| 3| 3| 3| 3| 3| 2| 3| 9| 3| 7| 3| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3|             
                                           | 2| 6| 9| 6| 6| 6| 3| 3| 8| 3| 0| 3| 7| 2| 7| 7| 7| 7| 3| 3| 3| 3| 6| 3| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7|             
    0.00500%                               | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Parenchyma, Vacuolization            |                                                                          |             
          Cytoplasmic, Diffuse             |                                                                2         |             
      Thalamus, Mineralization             |    2  2  2           2     2  2        1        2     2  1     1  2     2|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                    1  1           1      |             
      Hyperplasia, Lymphoid                |          1           1              1  1                    1           1|             
      Infiltration Cellular, Histiocyte    |                      1                                         1         |             
      Leukocytosis                         |                                                                          |             
      Thrombosis                           |                                  X                                       |             
      Alveolar Epithelium, Hyperplasia     |                      2                                                   |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Exudate                              |                                              X                           |             
      Glands, Hyperplasia, Cystic          |                                  1        1  1                           |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Cornea, Inflammation, Chronic        |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Casts Protein                        |             2     1        1  1        1     3  1                        |             
      Cyst                                 |                                              X                           |             
      Glomerulosclerosis                   |                                              3                           |             
      Hemorrhage                           |                                                                          |             
      Hydronephrosis                       |                                                                          |             
      Hyperplasia, Lymphoid                | 1  1  2     1     3                    1  1  4        2     3            |             
      Metaplasia, Osseous                  |                                           1                              |             
      Mineralization                       |    1              1  1                          1                        |             
      Interstitium, Pigmentation           |                                              3                           |             
      Renal Tubule, Atrophy                |    1              1                          3                    2      |             
      Renal Tubule, Dilatation             |             1                                3                    1      |             
      Renal Tubule, Pigmentation           |                                                    1                     |             
      Renal Tubule, Regeneration           |    1  1  1  2  1     1  1  1  1  1     1     4     1  1     1  2     1  1|             
      Transitional Epithelium, Hyperplasia |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Hyperplasia, Lymphoid                |       3  1  1     1  1           1  1  1  3  1           2  3           1|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  52                                                               
NTP Experiment-Test: 05089-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 15:57:00  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 7| 7| 5| 7| 7| 5| 7| 3| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 6| 7|             
                             DAY ON TEST   | 5| 5| 5| 5| 5| 3| 3| 6| 3| 3| 4| 3| 9| 3| 3| 8| 3| 3| 3| 6| 3| 3| 3| 4| 3|             
                                           | 7| 5| 5| 7| 6| 3| 3| 4| 3| 3| 7| 7| 7| 7| 7| 5| 1| 3| 3| 1| 0| 3| 0| 8| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|             
    0.00500%                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |                +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |                +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |                +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Liver                                   |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                            3                       X                     |             
      Clear Cell Focus                     |                                                                          |             
      Hematopoietic Cell Proliferation     |                            2                                2            |             
      Hyperplasia, Focal                   |                3                 2        4           3                 2|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Inflammation, Chronic                |                                  3                                       |             
      Inflammation, Subacute               |                                           1           1                  |             
      Centrilobular, Necrosis              |                               2                                          |             
      Hepatocyte, Karyomegaly              |                                  2                                       |             
      Hepatocyte, Vacuolization Cytoplasmic|                                  3                                       |             
      Kupffer Cell, Hyperplasia            |                                                                          |             
      Lobules, Necrosis                    |                                              4           1           4   |             
                                            __________________________________________________________________________|             
   Mesentery                               |                +                                      +     +            |             
      Fat, Necrosis                        |                4                                      4                  |             
                                            __________________________________________________________________________|             
   Pancreas                                |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Cytoplasmic Alteration               |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                   2      |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                        3        3                 1     1|             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Fibrosis                             |                                                                          |             
      Mucosa, Hyperplasia                  |                      1              2              1                 2   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                         X                       X              X         |             
      Edema                                |                                              2                           |             
      Inflammation, Subacute               |                            2                                             |             
      Mucosa, Hyperplasia                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  53                                                               
NTP Experiment-Test: 05089-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 15:57:00  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 7| 7| 5| 7| 7| 5| 7| 3| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 6| 7|             
                             DAY ON TEST   | 5| 5| 5| 5| 5| 3| 3| 6| 3| 3| 4| 3| 9| 3| 3| 8| 3| 3| 3| 6| 3| 3| 3| 4| 3|             
                                           | 7| 5| 5| 7| 6| 3| 3| 4| 3| 3| 7| 7| 7| 7| 7| 5| 1| 3| 3| 1| 0| 3| 0| 8| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|             
    0.00500%                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                            X        X              X     X               |             
      Cyst                                 |                                  X                             X         |             
      X-Zone, Degeneration, Fatty          |                                                                          |             
      Zona Reticularis, Proliferation      |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                            2     1     3                                1|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |                +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Cyst                                 |                X                                                         |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                            1                             3               |             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hyperplasia, Focal    |                                                                          |             
      Pars Distalis, Hyperplasia           |                                                       3  2     3         |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |                +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 |                2  4  2     1              1     1           3     1  2  1|             
      Hyperplasia, Lymphoid                |                   3                                                      |             
      Inflammation, Subacute               |                            1                             1               |             
      Follicular Cell, Hyperplasia         |                   3                       1              2               |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |                                                                          |             
      Ectasia                              |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   |                +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +|             
      Angiectasis                          |                                           2              3               |             
      Cyst                                 |                      X                                X  X           X   |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                           4                    2         |             
      Hydrometra                           |    2              3  3  2        4        4              3               |             
      Hyperplasia, Cystic                  | 2  2  2  2  2  3  2  2  2  2  2  3  1  2  2  2  2  3  4  2  3  2  3  2  2|             
      Hyperplasia, Lymphoid                |                                                                         2|             
      Inflammation, Suppurative            |                                                 2                        |             
      Metaplasia, Squamous                 |                      2                                         1         |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  54                                                               
NTP Experiment-Test: 05089-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 15:57:00  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 7| 7| 5| 7| 7| 5| 7| 3| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 6| 7|             
                             DAY ON TEST   | 5| 5| 5| 5| 5| 3| 3| 6| 3| 3| 4| 3| 9| 3| 3| 8| 3| 3| 3| 6| 3| 3| 3| 4| 3|             
                                           | 7| 5| 5| 7| 6| 3| 3| 4| 3| 3| 7| 7| 7| 7| 7| 5| 1| 3| 3| 1| 0| 3| 0| 8| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|             
    0.00500%                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hypercellularity                     |                               2                                   2      |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Iliac, Hyperplasia, Lymphoid         |                            2                                             |             
      Mediastinal, Hyperplasia, Lymphoid   |                                           2                              |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                           2     3                        |             
      Hyperplasia, Plasma Cell             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Depletion Cellular                   |                               2                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hemorrhage                           |                                                                      1   |             
      Hyperplasia, Lymphoid                |                   2                                                      |             
                                            __________________________________________________________________________|             
   Spleen                                  |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                  2                                       |             
      Hematopoietic Cell Proliferation     |                1           3  3  2           2  2        3  2     1  3   |             
      Pigmentation, Hemosiderin            |                                                    2                     |             
      Lymphoid Follicle, Atrophy           |                               2                                      2   |             
      Lymphoid Follicle, Hyperplasia       |                                     3              2                    2|             
      Red Pulp, Atrophy                    |                                                                          |             
      Red Pulp, Hyperplasia                |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Angiectasis                          |                                                                          |             
      Cyst                                 |                                        X  X              X               |             
      Depletion Cellular                   |                               3                 3                    3   |             
      Ectopic Parathyroid Gland            |                                                                          |             
      Hyperplasia, Lymphoid                |                                                    3                     |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lobular                 |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                                             1  1         |             
      Inflammation, Chronic, Focal         |                                                 3                        |             
      Ulcer                                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperostosis                         |                                                       3  1           2   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                                     X                                    |             
      Necrosis                             |                                     2                                    |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  55                                                               
NTP Experiment-Test: 05089-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 15:57:00  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 7| 7| 5| 7| 7| 5| 7| 3| 7| 7| 5| 7| 7| 7| 6| 7| 7| 7| 6| 7|             
                             DAY ON TEST   | 5| 5| 5| 5| 5| 3| 3| 6| 3| 3| 4| 3| 9| 3| 3| 8| 3| 3| 3| 6| 3| 3| 3| 4| 3|             
                                           | 7| 5| 5| 7| 6| 3| 3| 4| 3| 3| 7| 7| 7| 7| 7| 5| 1| 3| 3| 1| 0| 3| 0| 8| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9|             
    0.00500%                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Parenchyma, Vacuolization            |                                                                          |             
          Cytoplasmic, Diffuse             |                                                                          |             
      Thalamus, Mineralization             |                      1  1           1  3     1  3  1     2  3  2        1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                |                            2                       2                     |             
      Infiltration Cellular, Histiocyte    |                                           4                              |             
      Leukocytosis                         |                                                                          |             
      Thrombosis                           |                                                    X                     |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Exudate                              |                                           X                              |             
      Glands, Hyperplasia, Cystic          |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Cornea, Inflammation, Chronic        |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |    +     +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Casts Protein                        |    1                                2        1                           |             
      Cyst                                 |                                                                          |             
      Glomerulosclerosis                   |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Hydronephrosis                       |                                                 2           2            |             
      Hyperplasia, Lymphoid                |                            2  1                                1         |             
      Metaplasia, Osseous                  |                                                                          |             
      Mineralization                       |                1                       1  1                             1|             
      Interstitium, Pigmentation           |                                                                          |             
      Renal Tubule, Atrophy                |                   4                       1                              |             
      Renal Tubule, Dilatation             |                                     3                                    |             
      Renal Tubule, Pigmentation           |                                                                          |             
      Renal Tubule, Regeneration           |          1     1  1     1        1  1  1  2  2     1  1        1  1     1|             
      Transitional Epithelium, Hyperplasia |                      1                                                   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |                +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Hyperplasia, Lymphoid                |                      2     2     1              4     2        2         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  56                                                               
NTP Experiment-Test: 05089-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 15:57:00  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 1| 9| 5| 5| 5| 5| 5|                                            |            |
                                           | 6| 6| 6| 7| 8| 7| 6| 8| 7| 6|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|                                            |      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |      A     |
    0.00500%                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +                                                            |  49        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +                                                            |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +                                                            |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +                                                            |  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +                                                            |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +                                                            |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +                                                            |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  A                                                            |  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +                                                            |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +                                                            |  49        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +                                                            |  50        |
      Basophilic Focus                     |    X                                                                     |      3  3.0|
      Clear Cell Focus                     |          X                                                               |      2     |
      Hematopoietic Cell Proliferation     |             2                                                            |      4  2.3|
      Hyperplasia, Focal                   |          3                                                               |     11  2.7|
      Hyperplasia, Lymphoid                |                                                                          |      2  1.0|
      Inflammation, Chronic                |                                                                          |      1  3.0|
      Inflammation, Subacute               |                                                                          |      3  1.0|
      Centrilobular, Necrosis              |                                                                          |      1  2.0|
      Hepatocyte, Karyomegaly              |                                                                          |      1  2.0|
      Hepatocyte, Vacuolization Cytoplasmic|                                                                          |      3  2.3|
      Kupffer Cell, Hyperplasia            |          2                                                               |      1  2.0|
      Lobules, Necrosis                    |             3                                                            |      4  3.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |          +                                                               |   8        |
      Fat, Necrosis                        |          4                                                               |      6  2.8|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +                                                            |  50        |
      Atrophy                              |                                                                          |      1  2.0|
      Cytoplasmic Alteration               |                                                                          |      2  2.5|
      Hyperplasia, Lymphoid                |                                                                          |      9  1.7|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +                                                            |  50        |
      Hyperplasia, Lymphoid                |       1                                                                  |     15  1.5|
      Necrosis                             |          4                                                               |      1  4.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +                                                            |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +                                                            |  50        |
      Edema                                |                                                                          |      1  2.0|
      Fibrosis                             |                                                                          |      1  1.0|
      Mucosa, Hyperplasia                  |                                                                          |      6  1.5|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +                                                            |  50        |
      Cyst                                 | X  X                                                                     |      8     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  57                                                               
NTP Experiment-Test: 05089-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 15:57:00  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 1| 9| 5| 5| 5| 5| 5|                                            |            |
                                           | 6| 6| 6| 7| 8| 7| 6| 8| 7| 6|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|                                            |      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |      A     |
    0.00500%                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Edema                                |                                                                          |      1  2.0|
      Inflammation, Subacute               |                                                                          |      1  2.0|
      Mucosa, Hyperplasia                  |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +                                                            |  50        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +                                                            |  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +                                                            |  50        |
      Accessory Adrenal Cortical Nodule    | X                                                                        |     10     |
      Cyst                                 |                                                                          |      2     |
      X-Zone, Degeneration, Fatty          |    3                                                                     |      2  2.0|
      Zona Reticularis, Proliferation      |             4                                                            |      1  4.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +                                                            |  50        |
      Hyperplasia                          |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +                                                            |  50        |
      Hyperplasia                          |                                                                          |      8  1.8|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +                                                            |  49        |
      Cyst                                 |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +                                                            |  50        |
      Pars Distalis, Angiectasis           |                                                                          |      3  2.0|
      Pars Distalis, Cyst                  |                                                                          |      1     |
      Pars Distalis, Hyperplasia, Focal    |                                                                          |      1  4.0|
      Pars Distalis, Hyperplasia           |                                                                          |      6  2.3|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +                                                            |  49        |
      Degeneration, Cystic                 | 1     1                                                                  |     26  1.4|
      Hyperplasia, Lymphoid                |    2                                                                     |      3  2.0|
      Inflammation, Subacute               |                                                                          |      3  1.3|
      Follicular Cell, Hyperplasia         |    4  2                                                                  |     10  1.8|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |                                                                          |   1        |
      Ectasia                              |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +                                                            |  46        |
      Angiectasis                          | 2  3        3                                                            |     13  2.4|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  58                                                               
NTP Experiment-Test: 05089-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 15:57:00  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 1| 9| 5| 5| 5| 5| 5|                                            |            |
                                           | 6| 6| 6| 7| 8| 7| 6| 8| 7| 6|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|                                            |      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |      A     |
    0.00500%                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Cyst                                 |    X     X  X                                                            |     11     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Angiectasis                          |             3                                                            |      4  3.3|
      Hydrometra                           |    4        4                                                            |     14  3.1|
      Hyperplasia, Cystic                  | 3  2  2  3     1  2  3  3  2                                             |     59  2.3|
      Hyperplasia, Lymphoid                |                                                                          |      2  2.0|
      Inflammation, Suppurative            |                                                                          |      2  2.0|
      Metaplasia, Squamous                 |                                                                          |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +                                                            |  50        |
      Hypercellularity                     |          2  2                                                            |      6  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +                                                            |  50        |
      Iliac, Hyperplasia, Lymphoid         |                                                                          |      1  2.0|
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  M  +                                                            |  49        |
      Hyperplasia, Lymphoid                |                                                                          |      4  3.0|
      Hyperplasia, Plasma Cell             | 2                                                                        |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +                                                            |  50        |
      Depletion Cellular                   |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     |             2                                                            |      1  2.0|
      Hemorrhage                           |             4                                                            |      3  2.0|
      Hyperplasia, Lymphoid                |                                                                          |      3  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +                                                            |  50        |
      Angiectasis                          |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     |          2  4                                                            |     19  2.6|
      Pigmentation, Hemosiderin            |    2                                                                     |      4  2.0|
      Lymphoid Follicle, Atrophy           |                                                                          |      2  2.0|
      Lymphoid Follicle, Hyperplasia       |       2                                                                  |      7  2.1|
      Red Pulp, Atrophy                    |                                                                          |      1  2.0|
      Red Pulp, Hyperplasia                |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +                                                            |  47        |
      Angiectasis                          | 2                                                                        |      1  2.0|
      Cyst                                 |    X                                                                     |     10     |
      Depletion Cellular                   |          3                                                               |      6  2.7|
      Ectopic Parathyroid Gland            |                                                                          |      1     |
      Hyperplasia, Lymphoid                | 3                                                                        |      2  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  59                                                               
NTP Experiment-Test: 05089-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 15:57:00  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 1| 9| 5| 5| 5| 5| 5|                                            |            |
                                           | 6| 6| 6| 7| 8| 7| 6| 8| 7| 6|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|                                            |      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |      A     |
    0.00500%                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +                                                            |  50        |
      Hyperplasia, Lobular                 |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +                                                            |  50        |
      Acanthosis                           |                                                                          |      2  1.0|
      Inflammation, Chronic, Focal         |                                                                          |      1  3.0|
      Ulcer                                |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +                                                            |  50        |
      Hyperostosis                         |       2                                                                  |      9  1.9|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +                                                            |  50        |
      Compression                          |                                                                          |      1     |
      Necrosis                             |                                                                          |      1  2.0|
      Parenchyma, Vacuolization            |                                                                          |            |
          Cytoplasmic, Diffuse             |                                                                          |      1  2.0|
      Thalamus, Mineralization             |       2  1  1                                                            |     27  1.7|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +                                                            |  50        |
      Hemorrhage                           |                                                                          |      3  1.0|
      Hyperplasia, Lymphoid                | 1                                                                        |      9  1.2|
      Infiltration Cellular, Histiocyte    |                                                                          |      3  2.0|
      Leukocytosis                         |             2                                                            |      1  2.0|
      Thrombosis                           |                                                                          |      2     |
      Alveolar Epithelium, Hyperplasia     |             1                                                            |      2  1.5|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +                                                            |  50        |
      Exudate                              |                                                                          |      2     |
      Glands, Hyperplasia, Cystic          |                                                                          |      3  1.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +                                                            |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     | +                                                                        |   1        |
      Cornea, Inflammation, Chronic        | 2                                                                        |      1  2.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         | +                                                                        |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +              +                                             |  53        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  60                                                               
NTP Experiment-Test: 05089-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 15:57:00  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 3| 3| 3| 1| 9| 5| 5| 5| 5| 5|                                            |            |
                                           | 6| 6| 6| 7| 8| 7| 6| 8| 7| 6|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|                                            |      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |      A     |
    0.00500%                               | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Casts Protein                        |                                                                          |     10  1.4|
      Cyst                                 |                                                                          |      1     |
      Glomerulosclerosis                   |                                                                          |      1  3.0|
      Hemorrhage                           |          2                                                               |      1  2.0|
      Hydronephrosis                       |                                                                          |      2  2.0|
      Hyperplasia, Lymphoid                |       3                                                                  |     14  1.9|
      Metaplasia, Osseous                  |                                                                          |      1  1.0|
      Mineralization                       |       1                                                                  |      9  1.0|
      Interstitium, Pigmentation           |                                                                          |      1  3.0|
      Renal Tubule, Atrophy                |          2                                                               |      7  2.0|
      Renal Tubule, Dilatation             |                                                                          |      4  2.0|
      Renal Tubule, Pigmentation           |                                                                          |      1  1.0|
      Renal Tubule, Regeneration           |       1                    1                                             |     34  1.2|
      Transitional Epithelium, Hyperplasia |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +                                                            |  49        |
      Edema                                |          3                                                               |      1  3.0|
      Hyperplasia, Lymphoid                |    2  3                                                                  |     21  1.8|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  61                                                               
NTP Experiment-Test: 05089-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 15:57:00  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|                                            |            |
                             DAY ON TEST   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |            |
                                           | 8| 7| 9| 8| 7| 1| 2| 0| 1| 0|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 8| 8| 8| 8| 9|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 8| 9| 9| 9| 9| 0|                                            |      A     |
    0.00500%                               | 6| 7| 8| 9| 0| 6| 7| 8| 9| 0|                                            |      L     |
     3 SSAC                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Uterus                                  |             +           +                                                |   2        |
      Endometrium, Cyst                    |             1           1                                                |      2  1.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |    +  +  +                 +                                             |   4        |
      Renal Tubule, Regeneration           |    1  1  1                 1                                             |      4  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  62                                                               
NTP Experiment-Test: 05089-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 15:57:00  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 6| 7| 7| 7| 7| 4| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 2| 8| 3| 3| 3| 3| 5| 3| 9| 3| 3| 3| 3| 7| 3| 3| 3| 3| 0| 3| 2| 3|             
                                           | 6| 6| 6| 0| 6| 6| 4| 4| 4| 7| 4| 1| 5| 5| 5| 5| 3| 5| 3| 3| 3| 6| 3| 7| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                               ANIMAL ID   | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
    0.0275%                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |          X                                                               |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                 2                        |             
      Basophilic Focus                     |                                     X                                    |             
      Clear Cell Focus                     | X                                   X                 X                  |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hemorrhage                           |                                              3                           |             
      Hyperplasia, Focal                   | 2  2        1  2     2  2           2                 3              3  2|             
      Hyperplasia, Lymphoid                |    1  3                 2                                            1   |             
      Inflammation, Chronic                |                                                             2            |             
      Inflammation, Subacute               |                               1                    1     1               |             
      Mineralization                       |                                                                          |             
      Mixed Cell Focus                     |                                                                          |             
      Hepatocyte, Cytomegaly               |                            2                                             |             
      Hepatocyte, Karyomegaly              |                            2                                2            |             
      Hepatocyte, Nuclear Alteration       |                            3                                             |             
      Hepatocyte, Vacuolization Cytoplasmic| 2        2                                                               |             
      Kupffer Cell, Hyperplasia            |                                                                          |             
      Kupffer Cell, Pigmentation           |                                                                          |             
      Lobules, Necrosis                    |                      1     2  1              1                           |             
                                            __________________________________________________________________________|             
   Mesentery                               |                   +                 +        +        +                  |             
      Fat, Necrosis                        |                   4                 4        3        2                  |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Cytoplasmic Alteration               |          3                                                               |             
      Focal Cellular Change                |                                                                          |             
      Hyperplasia, Lymphoid                |                   1                    2     1                           |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |          2        3  1                          1     2  1           2  3|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Diverticulum                         |                            2                                             |             
      Erosion                              |          2                                                               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  63                                                               
NTP Experiment-Test: 05089-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 15:57:00  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 6| 7| 7| 7| 7| 4| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 2| 8| 3| 3| 3| 3| 5| 3| 9| 3| 3| 3| 3| 7| 3| 3| 3| 3| 0| 3| 2| 3|             
                                           | 6| 6| 6| 0| 6| 6| 4| 4| 4| 7| 4| 1| 5| 5| 5| 5| 3| 5| 3| 3| 3| 6| 3| 7| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                               ANIMAL ID   | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
    0.0275%                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Inflammation, Suppurative            |                                     1                                    |             
      Mucosa, Hyperplasia                  |                                     3                                    |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                     X        X              X            |             
      Erosion                              |          2                                                     3         |             
      Inflammation, Subacute               |                         1                                                |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
      Hypertrophy                          |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Myocardium, Mineralization           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                X  X        X                    X  X           X     X   |             
      Cyst                                 |                                                                   X      |             
      Hyperplasia, Focal                   |          2                                   2                           |             
      Necrosis                             |                                                                          |             
      X-Zone, Degeneration, Fatty          |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                3              2                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |          1           1                 1                             2   |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |    X                                                                     |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                                                                          |             
      Pars Distalis, Hyperplasia           | 1                             1           3        1                     |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 | 2  2     2     2  1  2           2  1           1  3     2     1     2  2|             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Inflammation, Subacute               |                                                                          |             
      Follicular Cell, Hyperplasia         |                         1                 1  1     1        1        3   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                             +            |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |                            +                                             |             
      Ectasia                              |                            2                                             |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +|             
      Angiectasis                          |          2              2                                   3            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  64                                                               
NTP Experiment-Test: 05089-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 15:57:00  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 6| 7| 7| 7| 7| 4| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 2| 8| 3| 3| 3| 3| 5| 3| 9| 3| 3| 3| 3| 7| 3| 3| 3| 3| 0| 3| 2| 3|             
                                           | 6| 6| 6| 0| 6| 6| 4| 4| 4| 7| 4| 1| 5| 5| 5| 5| 3| 5| 3| 3| 3| 6| 3| 7| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                               ANIMAL ID   | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
    0.0275%                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Cyst                                 |       X  X        X  X        X     X     X  X                 X  X  X   |             
      Hyperplasia, Cystic                  |                                                                          |             
      Hyperplasia                          |          2                                                        2      |             
      Interstitial Cell, Hyperplasia       |                         3                                                |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                      2                             2                     |             
      Hydrometra                           | 1     3  4              4           3        4              4  3         |             
      Hyperplasia, Cystic                  | 3  3  3  2  4  3  2  2  2  3  3  1  2  3  3  3  1  4  2  4  3  3  4  3  2|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Metaplasia, Squamous                 |                         2                                                |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                           3                              |             
      Hypercellularity                     |                                  2                          X            |             
      Myelofibrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Iliac, Hematopoietic Cell            |                                                                          |             
          Proliferation                    |                                                                          |             
      Renal, Hematopoietic Cell            |                                                                          |             
          Proliferation                    |                                                                          |             
      Renal, Hyperplasia, Plasma Cell      |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                         2|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hemorrhage                           |                                     1                                    |             
      Hyperplasia, Lymphoid                |                                                       3                  |             
      Lymphatic, Dilatation                |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Congestion                           |                                                       2                  |             
      Hematopoietic Cell Proliferation     | 2  1  1     3        2           3  1                       1        2   |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Pigmentation, Hemosiderin            |                                     2                          2         |             
      Lymphoid Follicle, Atrophy           |          3                                                     2         |             
      Lymphoid Follicle, Hyperplasia       | 3                                                           2            |             
      Red Pulp, Hyperplasia                |                                              2                           |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  M  +  +  M  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                         2                                                |             
      Cyst                                 |                      X  X                    X                 X         |             
      Depletion Cellular                   |                                  3                             2         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  65                                                               
NTP Experiment-Test: 05089-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 15:57:00  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 6| 7| 7| 7| 7| 4| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 2| 8| 3| 3| 3| 3| 5| 3| 9| 3| 3| 3| 3| 7| 3| 3| 3| 3| 0| 3| 2| 3|             
                                           | 6| 6| 6| 0| 6| 6| 4| 4| 4| 7| 4| 1| 5| 5| 5| 5| 3| 5| 3| 3| 3| 6| 3| 7| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                               ANIMAL ID   | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
    0.0275%                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Epithelial Cell, Hyperplasia         |                      2                                                   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  |                            1     1                                       |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                      3                                                   |             
      Inflammation, Chronic                |                                                                          |             
      Ulcer                                |                      3                                                   |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperostosis                         |    2                                               3     2  2            |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                            X                                             |             
      Hemorrhage                           |                            2                                             |             
      Hydrocephalus                        |                            2                                             |             
      Thalamus, Mineralization             |          2     2     2  1  2  1     1        2  1     2     1  2  3      |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hemorrhage                           |    1  1                          4                                       |             
      Hyperplasia, Lymphoid                |          1              1           2     1  2                           |             
      Infiltration Cellular, Histiocyte    |             1                    3              4                        |             
      Inflammation, Chronic                |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |       1                                                                  |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Exudate                              |          X              X                                                |             
      Glands, Hyperplasia, Cystic          |          1              1                                                |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                +         |             
      Cataract                             |                                                                          |             
      Retina, Atrophy                      |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                         +                                                |             
      Hyperplasia, Focal                   |                                                                          |             
      Hyperplasia                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  66                                                               
NTP Experiment-Test: 05089-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 15:57:00  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 6| 7| 7| 7| 7| 4| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 2| 8| 3| 3| 3| 3| 5| 3| 9| 3| 3| 3| 3| 7| 3| 3| 3| 3| 0| 3| 2| 3|             
                                           | 6| 6| 6| 0| 6| 6| 4| 4| 4| 7| 4| 1| 5| 5| 5| 5| 3| 5| 3| 3| 3| 6| 3| 7| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                               ANIMAL ID   | 8| 8| 8| 8| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1|             
    0.0275%                                | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Casts Protein                        |                            3              1        1                     |             
      Cyst                                 |                                     X                                   X|             
      Glomerulosclerosis                   |                                                                          |             
      Hemorrhage                           |                                                          2               |             
      Hyperplasia, Lymphoid                |    1              3     1              1     1     1     1           2  2|             
      Metaplasia, Osseous                  |                                                                          |             
      Mineralization                       |       1  1  1     1           1        2  1  1                          1|             
      Interstitium, Pigmentation           |                               2                                          |             
      Papilla, Necrosis                    |             2                                                            |             
      Renal Tubule, Atrophy                |                               3        2           1                    3|             
      Renal Tubule, Dilatation             |                            2                                             |             
      Renal Tubule, Pigmentation           |                                                                          |             
      Renal Tubule, Regeneration           | 1           1              1  1     1  1  1  1     1  1     2     1  1   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                   2                 1  1  1  2        1  2        1     2|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  67                                                               
NTP Experiment-Test: 05089-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 15:57:00  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 7| 7| 4| 5| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 5| 5| 5| 5| 5| 3| 3| 8| 3| 3| 3| 1| 9| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3|             
                                           | 7| 6| 5| 6| 7| 7| 7| 0| 6| 7| 7| 9| 3| 3| 3| 1| 3| 4| 7| 7| 7| 7| 7| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
                               ANIMAL ID   | 1| 1| 1| 1| 2| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    0.0275%                                | 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  I  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     |                            X                                         X   |             
      Clear Cell Focus                     |                                                          X               |             
      Hematopoietic Cell Proliferation     |                      4                                                   |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Focal                   |                   2                                                      |             
      Hyperplasia, Lymphoid                |                                        1                 1           1   |             
      Inflammation, Chronic                |    1                                                                     |             
      Inflammation, Subacute               |             1                                                            |             
      Mineralization                       |                                                                         4|             
      Mixed Cell Focus                     | X                                                                        |             
      Hepatocyte, Cytomegaly               |                                                                          |             
      Hepatocyte, Karyomegaly              |                                                                          |             
      Hepatocyte, Nuclear Alteration       |                                                                          |             
      Hepatocyte, Vacuolization Cytoplasmic|                                                                          |             
      Kupffer Cell, Hyperplasia            |                                              2                 2         |             
      Kupffer Cell, Pigmentation           |                                                                2         |             
      Lobules, Necrosis                    | 2                    3                                                   |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                              +     +                     |             
      Fat, Necrosis                        |                                                    2                     |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                            1              2     1                        |             
      Cytoplasmic Alteration               |                                     4                                    |             
      Focal Cellular Change                |                         X                                                |             
      Hyperplasia, Lymphoid                |                                                                      2   |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |    1                 1                 1     2        1  1     2  2  2   |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Diverticulum                         |                                                                          |             
      Erosion                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  68                                                               
NTP Experiment-Test: 05089-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 15:57:00  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 7| 7| 4| 5| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 5| 5| 5| 5| 5| 3| 3| 8| 3| 3| 3| 1| 9| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3|             
                                           | 7| 6| 5| 6| 7| 7| 7| 0| 6| 7| 7| 9| 3| 3| 3| 1| 3| 4| 7| 7| 7| 7| 7| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
                               ANIMAL ID   | 1| 1| 1| 1| 2| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    0.0275%                                | 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Mucosa, Hyperplasia                  |                                                                2         |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                           X           X                  |             
      Erosion                              |                                                                          |             
      Inflammation, Subacute               |                                                                      2   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                   +      |             
      Hypertrophy                          |                                                                   3      |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Myocardium, Mineralization           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |       X                                X           X           X         |             
      Cyst                                 |                                                                          |             
      Hyperplasia, Focal                   |          1  1                    1                                       |             
      Necrosis                             |                         1                                                |             
      X-Zone, Degeneration, Fatty          |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                1                                                         |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                        3              2           1      |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                            3                                         2   |             
      Pars Distalis, Hyperplasia           |                2           2           2                                 |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 |       1           2  1  1     2  1  1           1     2  1  1        1  1|             
      Infiltration Cellular, Lymphocyte    |       1                                                                  |             
      Inflammation, Subacute               |                                                 1                        |             
      Follicular Cell, Hyperplasia         |                            3           1                 1     4  1  1   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |                                           +                              |             
      Ectasia                              |                                           3                              |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                3              2                                      2   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  69                                                               
NTP Experiment-Test: 05089-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 15:57:00  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 7| 7| 4| 5| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 5| 5| 5| 5| 5| 3| 3| 8| 3| 3| 3| 1| 9| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3|             
                                           | 7| 6| 5| 6| 7| 7| 7| 0| 6| 7| 7| 9| 3| 3| 3| 1| 3| 4| 7| 7| 7| 7| 7| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
                               ANIMAL ID   | 1| 1| 1| 1| 2| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    0.0275%                                | 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Cyst                                 |             X                    X     X        X  X                     |             
      Hyperplasia, Cystic                  |                                                                          |             
      Hyperplasia                          |                                                                          |             
      Interstitial Cell, Hyperplasia       |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                   3      |             
      Hydrometra                           |                   3     4                 4  4  2  4        4  4     3   |             
      Hyperplasia, Cystic                  | 2  2  2  3  3  2  2  2  2  2  3  1  2  2  4     3  3  3  3  3     1  2  2|             
      Hyperplasia, Lymphoid                |                            2                                             |             
      Inflammation, Suppurative            |    2                    2                                2               |             
      Metaplasia, Squamous                 |                                                             3            |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Hypercellularity                     |                   3  4                                         2         |             
      Myelofibrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Iliac, Hematopoietic Cell            |                                                                          |             
          Proliferation                    |                      4                                                   |             
      Renal, Hematopoietic Cell            |                                                                          |             
          Proliferation                    |                      3                                                   |             
      Renal, Hyperplasia, Plasma Cell      |                      3                                                   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                      2                                                   |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Lymphatic, Dilatation                |             3                                                            |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                             3            |             
      Congestion                           |                         3                                                |             
      Hematopoietic Cell Proliferation     |                1  3  4           4        2  4     2        1  2  1  1   |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Pigmentation, Hemosiderin            |                                     2  2                                 |             
      Lymphoid Follicle, Atrophy           |                         2        3                                       |             
      Lymphoid Follicle, Hyperplasia       |                2                                         2  2            |             
      Red Pulp, Hyperplasia                |                                        2                                 |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Angiectasis                          |                            2                                             |             
      Cyst                                 |    X  X           X                                                      |             
      Depletion Cellular                   |                         2        2                                       |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  70                                                               
NTP Experiment-Test: 05089-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 15:57:00  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 7| 7| 4| 5| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 5| 5| 5| 5| 5| 3| 3| 8| 3| 3| 3| 1| 9| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3|             
                                           | 7| 6| 5| 6| 7| 7| 7| 0| 6| 7| 7| 9| 3| 3| 3| 1| 3| 4| 7| 7| 7| 7| 7| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
                               ANIMAL ID   | 1| 1| 1| 1| 2| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    0.0275%                                | 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Epithelial Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                                                          |             
      Inflammation, Chronic                |                      1                                                   |             
      Ulcer                                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperostosis                         |                            2                                1  2         |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                  +                                       |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Hydrocephalus                        |                                                                          |             
      Thalamus, Mineralization             | 2  2  2  2  1  2              2  2  2           2  3        2     1  2  2|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                     3        2                       2   |             
      Hemorrhage                           |       1                             3                                    |             
      Hyperplasia, Lymphoid                |                2  2        1                 2                 1     2  3|             
      Infiltration Cellular, Histiocyte    |                                        4                    2     2      |             
      Inflammation, Chronic                |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                                                   2      |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Exudate                              |                   X                             X                        |             
      Glands, Hyperplasia, Cystic          |                   1                             1                        |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                         +|             
      Cataract                             |                                                                         3|             
      Retina, Atrophy                      |                                                                         4|             
                                            __________________________________________________________________________|             
   Harderian Gland                         |          +     +                       +     +                    +     +|             
      Hyperplasia, Focal                   |                                                                   1     1|             
      Hyperplasia                          |                3                                                         |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  71                                                               
NTP Experiment-Test: 05089-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 15:57:00  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 7| 7| 4| 5| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 5| 5| 5| 5| 5| 3| 3| 8| 3| 3| 3| 1| 9| 3| 3| 3| 3| 0| 3| 3| 3| 3| 3| 3| 3|             
                                           | 7| 6| 5| 6| 7| 7| 7| 0| 6| 7| 7| 9| 3| 3| 3| 1| 3| 4| 7| 7| 7| 7| 7| 8| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
                               ANIMAL ID   | 1| 1| 1| 1| 2| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    0.0275%                                | 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Casts Protein                        |                                              2                       1  1|             
      Cyst                                 |                                                       X        X         |             
      Glomerulosclerosis                   |       2                                                                  |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                | 1  1           2     1              1  1  1        1        1  3         |             
      Metaplasia, Osseous                  |                                                                   1      |             
      Mineralization                       |                                     1                       1  2         |             
      Interstitium, Pigmentation           |                                                                          |             
      Papilla, Necrosis                    |                                                                          |             
      Renal Tubule, Atrophy                |                                           1           1        2  1      |             
      Renal Tubule, Dilatation             |                                                                          |             
      Renal Tubule, Pigmentation           |                      3                             4                     |             
      Renal Tubule, Regeneration           | 1  1  1  1     1  1  1     1  1        1  1  2  1  1        1     1  1   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |       2              1     1           1     2           2     1  1      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  72                                                               
NTP Experiment-Test: 05089-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 15:57:00  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 6| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 3| 5| 3| 3| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 8| 9| 8| 8| 1| 6| 8| 7| 6| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 4|                                            |      A     |
    0.0275%                                | 6| 7| 8| 9| 0| 6| 7| 8| 9| 0|                                            |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cyst                                 |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  57        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Angiectasis                          |                                                                          |      1  2.0|
      Basophilic Focus                     |       3              3     X                                             |      6  3.0|
      Clear Cell Focus                     |                                                                          |      4     |
      Hematopoietic Cell Proliferation     |                                                                          |      1  4.0|
      Hemorrhage                           |                                                                          |      1  3.0|
      Hyperplasia, Focal                   |       2                                                                  |     12  2.1|
      Hyperplasia, Lymphoid                |                                                                          |      7  1.4|
      Inflammation, Chronic                |                   1                                                      |      3  1.3|
      Inflammation, Subacute               |       1                                                                  |      5  1.0|
      Mineralization                       |                                                                          |      1  4.0|
      Mixed Cell Focus                     |                                                                          |      1     |
      Hepatocyte, Cytomegaly               |                                                                          |      1  2.0|
      Hepatocyte, Karyomegaly              |                                                                          |      2  2.0|
      Hepatocyte, Nuclear Alteration       |                                                                          |      1  3.0|
      Hepatocyte, Vacuolization Cytoplasmic|    2                                                                     |      3  2.0|
      Kupffer Cell, Hyperplasia            |             3                                                            |      3  2.3|
      Kupffer Cell, Pigmentation           |                                                                          |      1  2.0|
      Lobules, Necrosis                    |       1     1                                                            |      8  1.5|
                                            __________________________________________________________________________|____________|
   Mesentery                               |    +        +                                                            |   8        |
      Fat, Necrosis                        |    3                                                                     |      6  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Atrophy                              |                                                                          |      3  1.3|
      Cytoplasmic Alteration               |    4                                                                     |      3  3.7|
      Focal Cellular Change                |                                                                          |      1     |
      Hyperplasia, Lymphoid                |                                                                          |      4  1.5|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperplasia, Lymphoid                |          2           1     2                                             |     20  1.7|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  73                                                               
NTP Experiment-Test: 05089-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 15:57:00  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 6| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 3| 5| 3| 3| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 8| 9| 8| 8| 1| 6| 8| 7| 6| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 4|                                            |      A     |
    0.0275%                                | 6| 7| 8| 9| 0| 6| 7| 8| 9| 0|                                            |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cyst                                 |                X                                                         |      1     |
      Diverticulum                         |                                                                          |      1  2.0|
      Erosion                              |                                                                          |      1  2.0|
      Inflammation, Suppurative            |                                                                          |      1  1.0|
      Mucosa, Hyperplasia                  |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cyst                                 |                                                                          |      5     |
      Erosion                              |                                                                          |      2  2.5|
      Inflammation, Subacute               |                                                                          |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   1        |
      Hypertrophy                          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Myocardium, Mineralization           |             2                                                            |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Accessory Adrenal Cortical Nodule    | X              X                                                         |     13     |
      Cyst                                 |                                                                          |      1     |
      Hyperplasia, Focal                   |                                                                          |      5  1.4|
      Necrosis                             |                                                                          |      1  1.0|
      X-Zone, Degeneration, Fatty          |          3                                                               |      1  3.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperplasia                          |                                                                          |      3  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperplasia                          |    1                                                                     |      8  1.5|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Cyst                                 |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Pars Distalis, Angiectasis           |                                                                          |      2  2.5|
      Pars Distalis, Hyperplasia           |                                                                          |      7  1.7|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Degeneration, Cystic                 |             3              1                                             |     29  1.6|
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  1.0|
      Inflammation, Subacute               |       3                                                                  |      2  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  74                                                               
NTP Experiment-Test: 05089-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 15:57:00  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 6| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 3| 5| 3| 3| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 8| 9| 8| 8| 1| 6| 8| 7| 6| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 4|                                            |      A     |
    0.0275%                                | 6| 7| 8| 9| 0| 6| 7| 8| 9| 0|                                            |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Follicular Cell, Hyperplasia         |    1  4                                                                  |     14  1.7|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |                                                                          |   2        |
      Ectasia                              |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +                                             |  56        |
      Angiectasis                          |          2                                                               |      7  2.3|
      Cyst                                 |                                                                          |     16     |
      Hyperplasia, Cystic                  |                      3                                                   |      1  3.0|
      Hyperplasia                          |                                                                          |      2  2.0|
      Interstitial Cell, Hyperplasia       |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Angiectasis                          |                                                                          |      3  2.3|
      Hydrometra                           | 2  4  3  3                                                               |     21  3.3|
      Hyperplasia, Cystic                  | 2  2  3  2  2  2  3  2  3  3                                             |     58  2.5|
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
      Inflammation, Suppurative            |                                                                          |      3  2.0|
      Metaplasia, Squamous                 | 2                                                                        |      3  2.3|
                                            __________________________________________________________________________|____________|
   Vagina                                  |    +                                                                     |   1        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Angiectasis                          |                                                                          |      1  3.0|
      Hypercellularity                     |          2                                                               |      6  2.6|
      Myelofibrosis                        |             4                                                            |      1  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Iliac, Hematopoietic Cell            |                                                                          |            |
          Proliferation                    |                                                                          |      1  4.0|
      Renal, Hematopoietic Cell            |                                                                          |            |
          Proliferation                    |                                                                          |      1  3.0|
      Renal, Hyperplasia, Plasma Cell      |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  M  +  +  +  +                                             |  58        |
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
      Hemorrhage                           |                                                                          |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  75                                                               
NTP Experiment-Test: 05089-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 15:57:00  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 6| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 3| 5| 3| 3| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 8| 9| 8| 8| 1| 6| 8| 7| 6| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 4|                                            |      A     |
    0.0275%                                | 6| 7| 8| 9| 0| 6| 7| 8| 9| 0|                                            |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia, Lymphoid                |                   2                                                      |      2  2.5|
      Lymphatic, Dilatation                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Angiectasis                          |                                                                          |      1  3.0|
      Congestion                           |                2                                                         |      3  2.3|
      Hematopoietic Cell Proliferation     |          2  3                                                            |     22  2.1|
      Hyperplasia, Lymphoid                |                            3                                             |      1  3.0|
      Pigmentation, Hemosiderin            |                                                                          |      4  2.0|
      Lymphoid Follicle, Atrophy           |                                                                          |      4  2.5|
      Lymphoid Follicle, Hyperplasia       |                                                                          |      5  2.2|
      Red Pulp, Hyperplasia                |          3                                                               |      3  2.3|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +                                             |  55        |
      Angiectasis                          |                   3                                                      |      3  2.3|
      Cyst                                 |    X           X           X                                             |     10     |
      Depletion Cellular                   |                                                                          |      4  2.3|
      Hyperplasia, Lymphoid                |                   2                                                      |      1  2.0|
      Epithelial Cell, Hyperplasia         |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperplasia, Cystic                  |                                                                          |      2  1.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Acanthosis                           |                                                                          |      1  3.0|
      Inflammation, Chronic                |                                                                          |      1  1.0|
      Ulcer                                |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperostosis                         |                                                                          |      7  2.0|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Compression                          |                                                                          |      1     |
      Hemorrhage                           |                                                                          |      1  2.0|
      Hydrocephalus                        |                                                                          |      1  2.0|
      Thalamus, Mineralization             | 2        2  2        2  1                                                |     33  1.8|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  76                                                               
NTP Experiment-Test: 05089-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 15:57:00  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 7| 6| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 3| 5| 3| 3| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 8| 9| 8| 8| 1| 6| 8| 7| 6| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 3| 3| 3| 3| 3| 4|                                            |      A     |
    0.0275%                                | 6| 7| 8| 9| 0| 6| 7| 8| 9| 0|                                            |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Congestion                           |                                                                          |      3  2.3|
      Hemorrhage                           |    1                       1                                             |      7  1.7|
      Hyperplasia, Lymphoid                |    1                                                                     |     13  1.6|
      Infiltration Cellular, Histiocyte    |             3                                                            |      7  2.7|
      Inflammation, Chronic                |                      2                                                   |      1  2.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Exudate                              | X                                                                        |      5     |
      Glands, Hyperplasia, Cystic          | 1                                                                        |      5  1.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   2        |
      Cataract                             |                                                                          |      1  3.0|
      Retina, Atrophy                      |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |       +                                                                  |   8        |
      Hyperplasia, Focal                   |       1                                                                  |      3  1.0|
      Hyperplasia                          |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Casts Protein                        | 1                                                                        |      7  1.4|
      Cyst                                 |    X                                                                     |      5     |
      Glomerulosclerosis                   |                                                                          |      1  2.0|
      Hemorrhage                           |                                                                          |      1  2.0|
      Hyperplasia, Lymphoid                |       2        2  2                                                      |     22  1.5|
      Metaplasia, Osseous                  |    3                 2                                                   |      3  2.0|
      Mineralization                       |    1                                                                     |     13  1.2|
      Interstitium, Pigmentation           |                                                                          |      1  2.0|
      Papilla, Necrosis                    |                                                                          |      1  2.0|
      Renal Tubule, Atrophy                |       3     2                                                            |     10  1.9|
      Renal Tubule, Dilatation             |                                                                          |      1  2.0|
      Renal Tubule, Pigmentation           |                                                                          |      2  3.5|
      Renal Tubule, Regeneration           |          1        1  1     1                                             |     34  1.1|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperplasia, Lymphoid                | 1        1                 3                                             |     20  1.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  77                                                               
NTP Experiment-Test: 05089-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 15:57:00  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|                                            |            |
                             DAY ON TEST   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |            |
                                           | 7| 8| 9| 7| 9| 2| 0| 2| 2| 0|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 9| 9| 9| 9| 9|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 3| 3| 3| 3| 3|                                            |      A     |
    0.0275%                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |      L     |
    3 SSAC                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | M  +  +  +  +  +  +  +  +  +                                             |   9        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  M                                             |   9        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Inflammation, Chronic                |                   1  1                                                   |      2  1.0|
      Lobules, Necrosis                    |                            1                                             |      1  1.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Hyperplasia, Lymphoid                |                         1                                                |      1  1.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | M  +  +  +  +  +  +  +  +  +                                             |   9        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | M  +  +  +  +  +  +  +  +  +                                             |   9        |
      Accessory Adrenal Cortical Nodule    |    X              X  X                                                   |      3     |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | M  +  +  +  +  +  +  +  +  +                                             |   9        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Hyperplasia                          |       2                                                                  |      1  2.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Ectopic Thymus                       |                      X                                                   |      1     |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  I  +  +  +  +  +  +  +                                             |   9        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  78                                                               
NTP Experiment-Test: 05089-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 15:57:00  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|                                            |            |
                             DAY ON TEST   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |            |
                                           | 7| 8| 9| 7| 9| 2| 0| 2| 2| 0|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 9| 9| 9| 9| 9|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 3| 3| 3| 3| 3|                                            |      A     |
    0.0275%                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |      L     |
    3 SSAC                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  M                                             |   9        |
      Cyst                                 |          X                                                               |      1     |
      Developmental Malformation           |          X                                                               |      1     |
      Hemorrhage                           |          4                                                               |      1  4.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Hypercellularity                     |          2                                                               |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Hematopoietic Cell Proliferation     |          3                                                               |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Hyperplasia, Lobular                 |          2                                                               |      1  2.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Hemorrhage                           |                         1                                                |      1  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Renal Tubule, Regeneration           | 1                                                                        |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  79                                                               
NTP Experiment-Test: 05089-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 15:57:00  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|                                            |            |
                             DAY ON TEST   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |            |
                                           | 7| 8| 9| 7| 9| 2| 0| 2| 2| 0|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 9| 9| 9| 9| 9|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 3| 3| 3| 3| 3|                                            |      A     |
    0.0275%                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |      L     |
    3 SSAC                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  80                                                               
NTP Experiment-Test: 05089-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 15:57:00  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 3| 4| 7| 7| 6| 7| 2| 7| 5| 5| 7| 7| 7| 6|             
                             DAY ON TEST   | 1| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 6| 5| 3| 2| 8| 3| 6| 2| 7| 5| 1| 3| 3| 5|             
                                           | 7| 6| 6| 6| 6| 6| 4| 1| 5| 4| 4| 2| 3| 3| 6| 1| 3| 8| 8| 5| 8| 6| 5| 5| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
    0.0140%                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +|             
      Cyst                                 |                                                                          |             
      Dilatation                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                              2                           |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                     2                                    |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                           2                              |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                                                          |             
      Clear Cell Focus                     |                                              X  X                       X|             
      Hematopoietic Cell Proliferation     |                                     2                    4           4   |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Focal                   |       2                                   3                              |             
      Inflammation, Subacute               |                                                    2           3         |             
      Centrilobular, Necrosis              |                                     2                                    |             
      Hepatocyte, Vacuolization Cytoplasmic|                                           2        4     2               |             
      Kupffer Cell, Hyperplasia            |                                              2        2                 2|             
      Lobules, Necrosis                    |                   1              3     1                 1     2     1   |             
                                            __________________________________________________________________________|             
   Mesentery                               |             +                 +                 +        +  +        +  +|             
      Fat, Necrosis                        |             3                                   4           3        3   |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                         1|             
      Cyst                                 |       X                                                                  |             
      Cytoplasmic Alteration               |                                     3     3        3           4        3|             
      Focal Cellular Change                | X                                                                        |             
      Hyperplasia, Lymphoid                |    1        2                                         1                  |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |    2  1                 1              2                                 |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                2         |             
      Inflammation, Suppurative            |                                                                1        2|             
      Ulcer                                |                                                          1               |             
      Mucosa, Hyperplasia                  |                      1                    2           1        2        2|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  81                                                               
NTP Experiment-Test: 05089-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 15:57:00  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 3| 4| 7| 7| 6| 7| 2| 7| 5| 5| 7| 7| 7| 6|             
                             DAY ON TEST   | 1| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 6| 5| 3| 2| 8| 3| 6| 2| 7| 5| 1| 3| 3| 5|             
                                           | 7| 6| 6| 6| 6| 6| 4| 1| 5| 4| 4| 2| 3| 3| 6| 1| 3| 8| 8| 5| 8| 6| 5| 5| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
    0.0140%                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                 X  X        X            |             
      Edema                                |                                                                          |             
      Erosion                              |                                                                          |             
      Inflammation, Subacute               |                                                                      2   |             
      Metaplasia, Squamous                 |                                           2                              |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Myocardium, Fibrosis                 |          2                                                           1   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                                              X  X     X              X   |             
      Cyst                                 |                   X                                                      |             
      Developmental Malformation           |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                      3   |             
      Hyperplasia, Focal                   |          2           1                                         2         |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                   1                                      1  1     1      |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 | X     X                                                                  |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                                                                          |             
      Pars Distalis, Hyperplasia           |          1        1        1                 2                 2         |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 |    2  1  1        1  2        2     3              1  2              3  2|             
      Inflammation, Subacute               |                                                                          |             
      Follicle, Cyst                       |                                                                          |             
      Follicular Cell, Hyperplasia         |    1           3                                1                        |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |                                                                          |             
      Ectasia                              |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |          3                                   2     3              4      |             
      Cyst                                 |                   X  X  X                    X        X  X     X  X      |             
      Hemorrhage                           |                                  4                                       |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  82                                                               
NTP Experiment-Test: 05089-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 15:57:00  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 3| 4| 7| 7| 6| 7| 2| 7| 5| 5| 7| 7| 7| 6|             
                             DAY ON TEST   | 1| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 6| 5| 3| 2| 8| 3| 6| 2| 7| 5| 1| 3| 3| 5|             
                                           | 7| 6| 6| 6| 6| 6| 4| 1| 5| 4| 4| 2| 3| 3| 6| 1| 3| 8| 8| 5| 8| 6| 5| 5| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
    0.0140%                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Interstitial Cell, Hyperplasia       |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                      2  2  2              2                              |             
      Hydrometra                           | 3  4  4     4  2     4  3                 2  3        4     3  4         |             
      Hyperplasia, Cystic                  | 2  2  2  3  2     2  4  3  2  4     2  1  2  2  3  1  2  2  2  3  2     2|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Inflammation, Suppurative            |                                                                      4   |             
      Metaplasia, Squamous                 |                                                                         1|             
      Myometrium, Fibrosis                 |             2                                                            |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hypercellularity                     |          X                                               2     2     4   |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Iliac, Hematopoietic Cell            |                                                                          |             
          Proliferation                    |                                                                          |             
      Iliac, Hemorrhage                    |                                                                          |             
      Iliac, Hyperplasia, Plasma Cell      |                                                                          |             
      Iliac, Lymphatic, Dilatation         |                         3                                                |             
      Mediastinal, Hematopoietic Cell      |                                                                          |             
          Proliferation                    |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia, Lymphoid                |                         2           3                                    |             
      Hyperplasia, Plasma Cell             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                         2                                            3   |             
      Hemorrhage                           |                      2  1                                4               |             
      Hyperplasia, Lymphoid                |                            2                                             |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |             1           1     2     4        4        4  2  1        4  2|             
      Lymphoid Follicle, Atrophy           |                                                                          |             
      Lymphoid Follicle, Hyperplasia       |    2  2                                                                  |             
      Red Pulp, Hyperplasia                |                            3                                             |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  M|             
      Angiectasis                          |                            2                                             |             
      Cyst                                 |    X                       X                                   X  X      |             
      Depletion Cellular                   |    2                 2           2        2                 2        3   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  |                                     1        1                           |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  83                                                               
NTP Experiment-Test: 05089-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 15:57:00  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 3| 4| 7| 7| 6| 7| 2| 7| 5| 5| 7| 7| 7| 6|             
                             DAY ON TEST   | 1| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 6| 5| 3| 2| 8| 3| 6| 2| 7| 5| 1| 3| 3| 5|             
                                           | 7| 6| 6| 6| 6| 6| 4| 1| 5| 4| 4| 2| 3| 3| 6| 1| 3| 8| 8| 5| 8| 6| 5| 5| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
    0.0140%                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperostosis                         |                   2     3     3        1                                2|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                         +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hemorrhage                           |                                                    3                     |             
      Hydrocephalus                        |                                                    2                     |             
      Inflammation, Chronic                |                                                                          |             
      Necrosis                             |                                                    2                     |             
      Thalamus, Mineralization             | 2     1  2  1  2  2  2  2  1  3  2  1  2  2  2  2  2  2  2  2  2  2  2  1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           | 3                                                                        |             
      Fibrosis                             |             2                                                            |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                |                1  1     2                    2  2              1     1   |             
      Infiltration Cellular, Histiocyte    |                         3                                                |             
      Leukocytosis                         |                                  2                                       |             
      Thrombosis                           |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |             2                                                            |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Exudate                              |                                                                         X|             
      Glands, Hyperplasia, Cystic          |    1                                                  1  1               |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                         2|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Cataract                             |                                                                          |             
      Cornea, Inflammation, Chronic        |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                               +              +                           |             
      Cyst                                 |                                                                          |             
      Hyperplasia, Focal                   |                               3                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Casts Protein                        |             1                                   1  1                     |             
      Glomerulosclerosis                   |                                                                          |             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  84                                                               
NTP Experiment-Test: 05089-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 15:57:00  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 3| 4| 7| 7| 6| 7| 2| 7| 5| 5| 7| 7| 7| 6|             
                             DAY ON TEST   | 1| 3| 3| 3| 3| 3| 3| 6| 3| 3| 3| 6| 5| 3| 2| 8| 3| 6| 2| 7| 5| 1| 3| 3| 5|             
                                           | 7| 6| 6| 6| 6| 6| 4| 1| 5| 4| 4| 2| 3| 3| 6| 1| 3| 8| 8| 5| 8| 6| 5| 5| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4|             
    0.0140%                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Hydronephrosis                       |                                                                          |             
      Hyperplasia, Lymphoid                |    1  1        1                    2                             1      |             
      Metaplasia, Osseous                  |                                              1                           |             
      Mineralization                       |    1  1                 1                 1     1        1        1     3|             
      Interstitium, Pigmentation           |                            1                                             |             
      Renal Tubule, Atrophy                |                            1              2                       1      |             
      Renal Tubule, Cytoplasmic Alteration |                                                                          |             
      Renal Tubule, Dilatation             |                                                                      2   |             
      Renal Tubule, Necrosis               |                                  3                                       |             
      Renal Tubule, Pigmentation           |                                  3                                       |             
      Renal Tubule, Regeneration           |    1  2  1  1     1     1  1        1  1  3  1  1  1              1  4  3|             
      Transitional Epithelium, Hyperplasia |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Hyperplasia, Lymphoid                |    2     1  1  2  1        1        1  3  1  2     1              2      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  85                                                               
NTP Experiment-Test: 05089-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 15:57:00  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 5| 5| 5| 5| 5| 3| 3| 3| 3| 3| 3| 3| 3| 5| 6| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 5| 7| 6| 6| 6| 6| 6| 6| 6| 6| 0| 7| 5| 7| 1| 7| 6| 7| 1| 1| 7| 7| 7| 0| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|             
    0.0140%                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                            X                                             |             
      Dilatation                           |                                        3                                 |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Necrosis                             |                                                 3                        |             
                                            __________________________________________________________________________|             
   Intestine Large                         |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                   X                                            3         |             
      Clear Cell Focus                     |                                              X                           |             
      Hematopoietic Cell Proliferation     |                                                                      2   |             
      Hemorrhage                           |                   3                                                      |             
      Hyperplasia, Focal                   |                               2  3                                       |             
      Inflammation, Subacute               |                         1                                               1|             
      Centrilobular, Necrosis              |                                                                          |             
      Hepatocyte, Vacuolization Cytoplasmic|                   2                    4                       2         |             
      Kupffer Cell, Hyperplasia            |                                                                          |             
      Lobules, Necrosis                    |                                        1                             3   |             
                                            __________________________________________________________________________|             
   Mesentery                               |                   +                       +  +  +                        |             
      Fat, Necrosis                        |                   3                          3  3                        |             
                                            __________________________________________________________________________|             
   Pancreas                                |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Cyst                                 |                                                                          |             
      Cytoplasmic Alteration               |                                     4  3                                 |             
      Focal Cellular Change                |                                                                          |             
      Hyperplasia, Lymphoid                |                      3                                                   |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                       1              2   |             
                                            __________________________________________________________________________|             
   Stomach                                 |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Ulcer                                |                                                                          |             
      Mucosa, Hyperplasia                  |                                                 3                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  86                                                               
NTP Experiment-Test: 05089-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 15:57:00  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 5| 5| 5| 5| 5| 3| 3| 3| 3| 3| 3| 3| 3| 5| 6| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 5| 7| 6| 6| 6| 6| 6| 6| 6| 6| 0| 7| 5| 7| 1| 7| 6| 7| 1| 1| 7| 7| 7| 0| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|             
    0.0140%                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                      X  X        X                       X               |             
      Edema                                |                                                                          |             
      Erosion                              |                                        1                                 |             
      Inflammation, Subacute               |                                                                          |             
      Metaplasia, Squamous                 |                      1                                                   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Myocardium, Fibrosis                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                   X        X                                      X      |             
      Cyst                                 |                                                                          |             
      Developmental Malformation           |                                                                X         |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia, Focal                   |                      1                    3                              |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                  1     1                                 |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                   3        1                                            2|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |                +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                     X           X                        |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                            1                                3            |             
      Pars Distalis, Hyperplasia           |                            2                 1              2        1   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 |                1  3                    2  3     1  2  1  1        4  2  1|             
      Inflammation, Subacute               |                                                                         1|             
      Follicle, Cyst                       |                                              X              X           X|             
      Follicular Cell, Hyperplasia         |                                  1                          2  1         |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                 +                        |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |                                                                   +      |             
      Ectasia                              |                                                                   3      |             
                                            __________________________________________________________________________|             
   Ovary                                   |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Angiectasis                          |                                     3  3  3  2                           |             
      Cyst                                 |                X     X  X  X                       X     X        X     X|             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  87                                                               
NTP Experiment-Test: 05089-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 15:57:00  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 5| 5| 5| 5| 5| 3| 3| 3| 3| 3| 3| 3| 3| 5| 6| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 5| 7| 6| 6| 6| 6| 6| 6| 6| 6| 0| 7| 5| 7| 1| 7| 6| 7| 1| 1| 7| 7| 7| 0| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|             
    0.0140%                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Interstitial Cell, Hyperplasia       |                                  2                                       |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                               2        4                             2   |             
      Hydrometra                           |                         4     3  3  3  3        3  3     3               |             
      Hyperplasia, Cystic                  | 3  1  1  2  2  3  1  2  2  2  2  2  2  2  2  2     2  2  3  2  2  3  2  2|             
      Hyperplasia, Lymphoid                |                            2                 2                           |             
      Inflammation, Suppurative            |                                                                         2|             
      Metaplasia, Squamous                 |                                                                   1      |             
      Myometrium, Fibrosis                 |                                                                          |             
                                            __________________________________________________________________________|             
   Vagina                                  |                   +                                                      |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hypercellularity                     |                                           2     3                    2   |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Iliac, Hematopoietic Cell            |                                                                          |             
          Proliferation                    |                                                                          |             
      Iliac, Hemorrhage                    |                                                                          |             
      Iliac, Hyperplasia, Plasma Cell      |                                                                          |             
      Iliac, Lymphatic, Dilatation         |                                                                          |             
      Mediastinal, Hematopoietic Cell      |                                                                          |             
          Proliferation                    |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Hyperplasia, Plasma Cell             |                                                                2         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hemorrhage                           |                               2                             1            |             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                      2        3        4  4              2     3     4   |             
      Lymphoid Follicle, Atrophy           |                                        3                                 |             
      Lymphoid Follicle, Hyperplasia       |                2                                               2        2|             
      Red Pulp, Hyperplasia                |                                                    2                     |             
                                            __________________________________________________________________________|             
   Thymus                                  |                +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                  2           3           3              2|             
      Cyst                                 |                   X                                                      |             
      Depletion Cellular                   |                                     2  4                                 |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  |                      1                                      1            |             
                                            __________________________________________________________________________|             
   Skin                                    |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  88                                                               
NTP Experiment-Test: 05089-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 15:57:00  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 5| 5| 5| 5| 5| 3| 3| 3| 3| 3| 3| 3| 3| 5| 6| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 5| 7| 6| 6| 6| 6| 6| 6| 6| 6| 0| 7| 5| 7| 1| 7| 6| 7| 1| 1| 7| 7| 7| 0| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|             
    0.0140%                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperostosis                         |                               1                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                               X                                          |             
      Hemorrhage                           |                                                                          |             
      Hydrocephalus                        |                                                                          |             
      Inflammation, Chronic                |                                                       2                  |             
      Necrosis                             |                                     3                                    |             
      Thalamus, Mineralization             |                   1     2     2  1  2  2  2  2  2  2  2  2  2  1     2   |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                     2                                    |             
      Fibrosis                             |                                           1                              |             
      Hemorrhage                           |                                                          1               |             
      Hyperplasia, Lymphoid                |                      1  1        1        2                 2  1         |             
      Infiltration Cellular, Histiocyte    |                   3                                3  3     3            |             
      Leukocytosis                         |                                                                          |             
      Thrombosis                           |                                        X                                 |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Exudate                              |                                                          X  X            |             
      Glands, Hyperplasia, Cystic          |                      1                                      1            |             
                                            __________________________________________________________________________|             
   Trachea                                 |                +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                       +                  |             
      Cataract                             |                                                       2                  |             
      Cornea, Inflammation, Chronic        |                                                       2                  |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                       +  +               |             
      Cyst                                 |                                                       X                  |             
      Hyperplasia, Focal                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Casts Protein                        |                1              1                       1              1   |             
      Glomerulosclerosis                   |                               1                                      1   |             
      Hemorrhage                           |                                  2                                       |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  89                                                               
NTP Experiment-Test: 05089-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 15:57:00  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 5| 5| 5| 5| 5| 3| 3| 3| 3| 3| 3| 3| 3| 5| 6| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 5| 7| 6| 6| 6| 6| 6| 6| 6| 6| 0| 7| 5| 7| 1| 7| 6| 7| 1| 1| 7| 7| 7| 0| 8|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6|             
    0.0140%                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Hydronephrosis                       |                                           3                              |             
      Hyperplasia, Lymphoid                |                               2     1              1  2           2  1  1|             
      Metaplasia, Osseous                  |                                        2                                 |             
      Mineralization                       |                1                 1        2                              |             
      Interstitium, Pigmentation           |                                                                      1   |             
      Renal Tubule, Atrophy                |                   1                                   1        2     1   |             
      Renal Tubule, Cytoplasmic Alteration |                                                                          |             
      Renal Tubule, Dilatation             |                                        2  3                              |             
      Renal Tubule, Necrosis               |                                        3                                 |             
      Renal Tubule, Pigmentation           |                                                                          |             
      Renal Tubule, Regeneration           | 1  1  1  1  1  1  2  1     1  1  2     3  3  1     1  1              1  1|             
      Transitional Epithelium, Hyperplasia |                                  3                                       |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                        3                                 |             
      Hyperplasia, Lymphoid                |                   1  1        3  1                    1  1        3  1  2|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  90                                                               
NTP Experiment-Test: 05089-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 15:57:00  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 7| 7| 7| 5| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 1| 3| 3| 3| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 0| 8| 2| 8| 7| 6| 8| 6| 8| 8|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|                                            |      A     |
    0.0140%                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +                                                            |  50        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +                                                            |  48        |
      Cyst                                 |                                                                          |      1     |
      Dilatation                           |                                                                          |      1  3.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
      Necrosis                             |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +                                                            |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +                                                            |  50        |
      Edema                                | 3           2                                                            |      3  2.3|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +                                                            |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +                                                            |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +                                                            |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +                                                            |  50        |
      Ulcer                                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +                                                            |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +                                                            |  49        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +                                                            |  50        |
      Basophilic Focus                     |                                                                          |      2  3.0|
      Clear Cell Focus                     |                                                                          |      4     |
      Hematopoietic Cell Proliferation     |             4                                                            |      5  3.2|
      Hemorrhage                           |                                                                          |      1  3.0|
      Hyperplasia, Focal                   |                                                                          |      4  2.5|
      Inflammation, Subacute               |                                                                          |      4  1.8|
      Centrilobular, Necrosis              |                                                                          |      1  2.0|
      Hepatocyte, Vacuolization Cytoplasmic|                                                                          |      6  2.7|
      Kupffer Cell, Hyperplasia            |                                                                          |      3  2.0|
      Lobules, Necrosis                    |                                                                          |      8  1.6|
                                            __________________________________________________________________________|____________|
   Mesentery                               | +                                                                        |  12        |
      Fat, Necrosis                        |                                                                          |      7  3.1|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +                                                            |  49        |
      Atrophy                              |                                                                          |      1  1.0|
      Cyst                                 |                                                                          |      1     |
      Cytoplasmic Alteration               |                                                                          |      7  3.3|
      Focal Cellular Change                |                                                                          |      1     |
      Hyperplasia, Lymphoid                |                                                                          |      4  1.8|
      Inflammation, Chronic Active         | 3                                                                        |      1  3.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +                                                            |  50        |
      Hyperplasia, Lymphoid                | 2  1     1                                                               |      9  1.4|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +                                                            |  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  91                                                               
NTP Experiment-Test: 05089-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 15:57:00  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 7| 7| 7| 5| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 1| 3| 3| 3| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 0| 8| 2| 8| 7| 6| 8| 6| 8| 8|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|                                            |      A     |
    0.0140%                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +                                                            |  50        |
      Edema                                |                                                                          |      1  2.0|
      Inflammation, Suppurative            |                                                                          |      2  1.5|
      Ulcer                                |                                                                          |      1  1.0|
      Mucosa, Hyperplasia                  |                                                                          |      6  1.8|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +                                                            |  50        |
      Cyst                                 |    X  X                                                                  |      9     |
      Edema                                |             2                                                            |      1  2.0|
      Erosion                              |                                                                          |      1  1.0|
      Inflammation, Subacute               |                                                                          |      1  2.0|
      Metaplasia, Squamous                 |                                                                          |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +                                                            |  50        |
      Myocardium, Fibrosis                 |                                                                          |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +                                                            |  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +                                                            |  50        |
      Accessory Adrenal Cortical Nodule    |    X                                                                     |      8     |
      Cyst                                 |                                                                          |      1     |
      Developmental Malformation           |                                                                          |      1     |
      Hematopoietic Cell Proliferation     |             3                                                            |      2  3.0|
      Hyperplasia, Focal                   |                                                                          |      5  1.8|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +                                                            |  50        |
      Hyperplasia                          |             1                                                            |      3  1.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +                                                            |  49        |
      Hyperplasia                          |             2                                                            |      8  1.5|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +                                                            |  48        |
      Cyst                                 |                                                                          |      4     |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +                                                            |  48        |
      Pars Distalis, Angiectasis           |                                                                          |      2  2.0|
      Pars Distalis, Hyperplasia           |                                                                          |      9  1.4|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +                                                            |  50        |
      Degeneration, Cystic                 |    3  1     3                                                            |     25  1.9|
      Inflammation, Subacute               |                                                                          |      1  1.0|
      Follicle, Cyst                       |                                                                          |      3     |
      Follicular Cell, Hyperplasia         |       1     1                                                            |      8  1.4|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  92                                                               
NTP Experiment-Test: 05089-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 15:57:00  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 7| 7| 7| 5| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 1| 3| 3| 3| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 0| 8| 2| 8| 7| 6| 8| 6| 8| 8|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|                                            |      A     |
    0.0140%                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENERAL BODY SYSTEM - cont                |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |    +                                                                     |   2        |
      Ectasia                              |    3                                                                     |      2  3.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +                                                            |  48        |
      Angiectasis                          |       2  4                                                               |     10  2.9|
      Cyst                                 |                                                                          |     16     |
      Hemorrhage                           |                                                                          |      1  4.0|
      Interstitial Cell, Hyperplasia       |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Angiectasis                          |                                                                          |      7  2.3|
      Hydrometra                           |    4  4                                                                  |     22  3.3|
      Hyperplasia, Cystic                  | 2  4  2  2  2  2  1  3  3  2                                             |     56  2.2|
      Hyperplasia, Lymphoid                |                                                                          |      2  2.0|
      Inflammation, Suppurative            | 2           4                                                            |      4  3.0|
      Metaplasia, Squamous                 |             3                                                            |      3  1.7|
      Myometrium, Fibrosis                 |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Vagina                                  |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +                                                            |  50        |
      Hypercellularity                     | 2           4                                                            |      9  2.6|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +                                                            |  50        |
      Iliac, Hematopoietic Cell            |                                                                          |            |
          Proliferation                    |             4                                                            |      1  4.0|
      Iliac, Hemorrhage                    |             3                                                            |      1  3.0|
      Iliac, Hyperplasia, Plasma Cell      |             3                                                            |      1  3.0|
      Iliac, Lymphatic, Dilatation         |                                                                          |      1  3.0|
      Mediastinal, Hematopoietic Cell      |                                                                          |            |
          Proliferation                    |             3                                                            |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +                                                            |  50        |
      Hematopoietic Cell Proliferation     |             2                                                            |      1  2.0|
      Hyperplasia, Lymphoid                |                                                                          |      2  2.5|
      Hyperplasia, Plasma Cell             |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +                                                            |  48        |
      Hematopoietic Cell Proliferation     |             4                                                            |      3  3.0|
      Hemorrhage                           |                                                                          |      5  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  93                                                               
NTP Experiment-Test: 05089-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 15:57:00  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 7| 7| 7| 5| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 1| 3| 3| 3| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 0| 8| 2| 8| 7| 6| 8| 6| 8| 8|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|                                            |      A     |
    0.0140%                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +                                                            |  49        |
      Hematopoietic Cell Proliferation     | 4           4                                                            |     19  2.9|
      Lymphoid Follicle, Atrophy           |                                                                          |      1  3.0|
      Lymphoid Follicle, Hyperplasia       |          2                                                               |      6  2.0|
      Red Pulp, Hyperplasia                |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  M  +  +  +                                                            |  46        |
      Angiectasis                          |                                                                          |      5  2.4|
      Cyst                                 |             X                                                            |      6     |
      Depletion Cellular                   |             3                                                            |      9  2.4|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +                                                            |  50        |
      Hyperplasia, Cystic                  |                                                                          |      4  1.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +                                                            |  50        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +                                                            |  50        |
      Hyperostosis                         |                                                                          |      6  2.0|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +                                                            |  50        |
      Cyst                                 |                                                                          |      1     |
      Hemorrhage                           |                                                                          |      1  3.0|
      Hydrocephalus                        |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Necrosis                             |                                                                          |      2  2.5|
      Thalamus, Mineralization             | 1  2  3  1  2                                                            |     44  1.8|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +                                                            |  50        |
      Congestion                           |                                                                          |      2  2.5|
      Fibrosis                             |                                                                          |      2  1.5|
      Hemorrhage                           | 3                                                                        |      2  2.0|
      Hyperplasia, Lymphoid                |    2     1                                                               |     15  1.4|
      Infiltration Cellular, Histiocyte    |                                                                          |      5  3.0|
      Leukocytosis                         |                                                                          |      1  2.0|
      Thrombosis                           |                                                                          |      1     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  94                                                               
NTP Experiment-Test: 05089-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 15:57:00  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 3| 7| 7| 7| 5| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 1| 3| 3| 3| 5| 5| 5| 5| 5| 5|                                            |            |
                                           | 0| 8| 2| 8| 7| 6| 8| 6| 8| 8|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|                                            |      A     |
    0.0140%                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Alveolar Epithelium, Hyperplasia     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +                                                            |  50        |
      Exudate                              |                                                                          |      3     |
      Glands, Hyperplasia, Cystic          |    1                                                                     |      6  1.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +                                                            |  49        |
      Inflammation, Suppurative            |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
      Cataract                             |                                                                          |      1  2.0|
      Cornea, Inflammation, Chronic        |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   4        |
      Cyst                                 |                                                                          |      1     |
      Hyperplasia, Focal                   |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +           +                                                |  56        |
      Casts Protein                        |          1                                                               |      8  1.0|
      Glomerulosclerosis                   |                                                                          |      2  1.0|
      Hemorrhage                           |                                                                          |      1  2.0|
      Hydronephrosis                       |                                                                          |      1  3.0|
      Hyperplasia, Lymphoid                |    1  1  1                                                               |     15  1.3|
      Metaplasia, Osseous                  |                                                                          |      2  1.5|
      Mineralization                       |       1     1                                                            |     13  1.2|
      Interstitium, Pigmentation           |                                                                          |      2  1.0|
      Renal Tubule, Atrophy                |                                                                          |      7  1.3|
      Renal Tubule, Cytoplasmic Alteration | 3                                                                        |      1  3.0|
      Renal Tubule, Dilatation             |             1                                                            |      4  2.0|
      Renal Tubule, Necrosis               |                                                                          |      2  3.0|
      Renal Tubule, Pigmentation           |                                                                          |      1  3.0|
      Renal Tubule, Regeneration           |    1  1     2           1                                                |     38  1.4|
      Transitional Epithelium, Hyperplasia |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +                                                            |  49        |
      Edema                                |                                                                          |      1  3.0|
      Hyperplasia, Lymphoid                |    1     1                                                               |     23  1.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  95                                                               
NTP Experiment-Test: 05089-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 15:57:00  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|                                            |            |
                             DAY ON TEST   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |            |
                                           | 8| 7| 9| 9| 8| 1| 2| 0| 2| 0|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 9| 9| 9| 9| 9|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 5| 6| 6| 6| 6| 7|                                            |      A     |
    0.0140%                                | 6| 7| 8| 9| 0| 6| 7| 8| 9| 0|                                            |      L     |
    3 SSAC                                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Uterus                                  |                   +                                                      |   1        |
      Endometrium, Cyst                    |                   2                                                      |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
 _____________________________________________________________________________________________________________________|____________|
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  96                                                               
NTP Experiment-Test: 05089-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 15:57:00  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 7| 7| 5| 7| 7| 7| 6| 7| 5| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 5| 7| 6|             
                             DAY ON TEST   | 3| 6| 1| 3| 3| 3| 3| 3| 3| 7| 3| 8| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 5| 3| 2|             
                                           | 5| 6| 6| 2| 5| 3| 4| 4| 4| 3| 4| 9| 4| 5| 4| 1| 4| 4| 3| 3| 3| 3| 2| 3| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                               ANIMAL ID   | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|             
    0.00700%                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Cyst                                 |    X                                                                     |             
      Dilatation                           |                                              3                           |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     |                                                                          |             
      Clear Cell Focus                     |          X                                                        X      |             
      Eosinophilic Focus                   |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia, Focal                   |             2                          3           2  3     1        1   |             
      Hyperplasia, Lymphoid                |                                           1                    1         |             
      Inflammation, Subacute               |                   1     1                                1               |             
      Mixed Cell Focus                     |                      X                                                   |             
      Centrilobular, Necrosis              |                                                                          |             
      Hepatocyte, Vacuolization Cytoplasmic|                                                                          |             
      Kupffer Cell, Hyperplasia            |    3                                                                     |             
      Kupffer Cell, Pigmentation           |                                                                          |             
      Lobules, Necrosis                    |       1              4                                                   |             
                                            __________________________________________________________________________|             
   Mesentery                               | +              +        +                                +        +  +   |             
      Fat, Necrosis                        | 2                                                        3        4  3   |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Atrophy                              |                                                                   2      |             
      Cyst                                 |                                                                   X      |             
      Cytoplasmic Alteration               |    4     3                                                               |             
      Hyperplasia, Lymphoid                | 2                                   1                       1            |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |    2              1                          1     1                     |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mucosa, Hyperplasia                  |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 | X  X                 X        X        X  X                          X   |             
      Erosion                              |          4                                                               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  97                                                               
NTP Experiment-Test: 05089-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 15:57:00  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 7| 7| 5| 7| 7| 7| 6| 7| 5| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 5| 7| 6|             
                             DAY ON TEST   | 3| 6| 1| 3| 3| 3| 3| 3| 3| 7| 3| 8| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 5| 3| 2|             
                                           | 5| 6| 6| 2| 5| 3| 4| 4| 4| 3| 4| 9| 4| 5| 4| 1| 4| 4| 3| 3| 3| 3| 2| 3| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                               ANIMAL ID   | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|             
    0.00700%                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Ulcer                                |       3                                                                  |             
      Mucosa, Hyperplasia                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                +                                                         |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Myocardium, Mineralization           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |       X  X  X     X           X     X              X        X            |             
      Clear Cell Focus                     |                                                    X                     |             
      Hyperplasia, Focal                   |                                              3  1        1               |             
      Capsule, Hyperplasia                 |                   3                                                      |             
      X-Zone, Degeneration, Fatty          |                   2                                                      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Hyperplasia                          | 1                                                        1               |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |          2                                                               |             
      Pars Distalis, Hyperplasia           |          2  1        2  1                                   1            |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 |    2  1     2  3  2  3     3  2  3     1           2  1  2  2  3  2     2|             
      Hyperplasia, Lymphoid                |                               2                                          |             
      Inflammation, Subacute               |                         1                             1                  |             
      Follicle, Cyst                       |                                                                          |             
      Follicular Cell, Hyperplasia         |                      3  2           1           1        1  1        1   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  I  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  M  +|             
      Angiectasis                          |    2                       2           2           2           2        2|             
      Cyst                                 |       X     X                          X                          X     X|             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                   3                                            2         |             
      Hydrometra                           |             4     3  4     3  4        3           3                 3   |             
      Hyperplasia, Cystic                  | 1  2  2  2  3  3  3  3  3  1  4     2  2  4  2  1  4  2  2  3  3  3  1  2|             
      Hyperplasia, Histiocytic             |                                                                          |             
      Hyperplasia, Lymphoid                |                                                          1               |             
      Metaplasia, Squamous                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  98                                                               
NTP Experiment-Test: 05089-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 15:57:00  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 7| 7| 5| 7| 7| 7| 6| 7| 5| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 5| 7| 6|             
                             DAY ON TEST   | 3| 6| 1| 3| 3| 3| 3| 3| 3| 7| 3| 8| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 5| 3| 2|             
                                           | 5| 6| 6| 2| 5| 3| 4| 4| 4| 3| 4| 9| 4| 5| 4| 1| 4| 4| 3| 3| 3| 3| 2| 3| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                               ANIMAL ID   | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|             
    0.00700%                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hypercellularity                     |       2                                                                  |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                 2                        |             
      Hyperplasia, Plasma Cell             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hemorrhage                           |          3                                                               |             
      Hyperplasia, Lymphoid                |                                                                      2   |             
      Hyperplasia, Plasma Cell             |                   2                                                      |             
      Lymphatic, Dilatation                |          3                                                        2      |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hematopoietic Cell Proliferation     | 2  2  3     2  3  2  2           3                                       |             
      Hemorrhage                           |                                                                          |             
      Pigmentation, Hemosiderin            |                                                       2                 2|             
      Lymphoid Follicle, Atrophy           |                                                                   3      |             
      Lymphoid Follicle, Hyperplasia       |                      2                             3        2            |             
      Red Pulp, Hyperplasia                |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Cyst                                 |    X                                X                             X      |             
      Depletion Cellular                   |    2  3  2                                   3                    3      |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Hyperplasia, Cystic                  |       1                          1           1                           |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |       2                                                                  |             
      Exudate                              |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Ulcer                                |       4                                                                  |             
      Subcutaneous Tissue, Edema           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperostosis                         |             2           1     3                                         2|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                +                                                         |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  99                                                               
NTP Experiment-Test: 05089-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 15:57:00  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 7| 7| 5| 7| 7| 7| 6| 7| 5| 7| 7| 7| 3| 7| 7| 7| 7| 7| 7| 5| 7| 6|             
                             DAY ON TEST   | 3| 6| 1| 3| 3| 3| 3| 3| 3| 7| 3| 8| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 5| 3| 2|             
                                           | 5| 6| 6| 2| 5| 3| 4| 4| 4| 3| 4| 9| 4| 5| 4| 1| 4| 4| 3| 3| 3| 3| 2| 3| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
                               ANIMAL ID   | 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8|             
    0.00700%                               | 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Thalamus, Mineralization             | 2  1  2     2  2  3     2  2  2  2  2  2  2  2  3  2        2  3  2  2  2|             
                                            __________________________________________________________________________|             
   Spinal Cord                             |    +                                                                     |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hemorrhage                           |          2                       3                    1                  |             
      Hyperplasia, Lymphoid                |    1              1        2  2        2  1           1                 4|             
      Infiltration Cellular, Histiocyte    | 2                          4                                2           4|             
      Thrombosis                           |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                                          2               |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Exudate                              |                                                 X     X        X         |             
      Glands, Hyperplasia, Cystic          | 1                       1                       2     1        1         |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
      Hyperplasia, Focal                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Casts Protein                        |    1                          1  1     1        1     1                  |             
      Cyst                                 |                      X                          X  X        X            |             
      Glomerulosclerosis                   |                         1                                         1      |             
      Hemorrhage                           |                                                                          |             
      Hydronephrosis                       |                               1                                          |             
      Hyperplasia, Lymphoid                | 2  1              1              1     1                                2|             
      Metaplasia, Osseous                  |                                        1                                 |             
      Mineralization                       |    1        1                 1     1                       1            |             
      Interstitium, Pigmentation           |                            2                                             |             
      Renal Tubule, Atrophy                |                            3              3                              |             
      Renal Tubule, Cytoplasmic Alteration |                                                                          |             
      Renal Tubule, Dilatation             |                                                                   2      |             
      Renal Tubule, Regeneration           | 1  2        2     1     1  1        1  1           1  1  1  1  1  1  1  1|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |    4                                                                     |             
      Edema                                |          3                                                               |             
      Hyperplasia, Lymphoid                | 3  1        1                       1           3  1                    1|             
      Inflammation, Chronic                |                                              1                           |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 100                                                               
NTP Experiment-Test: 05089-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 15:57:00  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 7| 7| 7| 6| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 5| 5| 5| 5| 5| 0| 1| 3| 4| 3| 0| 3| 0| 8| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3|             
                                           | 5| 6| 7| 6| 5| 7| 7| 6| 0| 6| 8| 8| 1| 4| 8| 8| 8| 6| 0| 6| 6| 6| 1| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
                               ANIMAL ID   | 8| 8| 8| 8| 9| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9|             
    0.00700%                               | 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Dilatation                           |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |                +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                        2                                 |             
                                            __________________________________________________________________________|             
   Intestine Small                         |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                        2                                 |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                2                                                         |             
      Basophilic Focus                     |                               X              3                           |             
      Clear Cell Focus                     |                                        X                                 |             
      Eosinophilic Focus                   |                X                                                         |             
      Hematopoietic Cell Proliferation     |                   3     4                                                |             
      Hyperplasia, Focal                   |                      3     3  2              2                           |             
      Hyperplasia, Lymphoid                |                                           2                              |             
      Inflammation, Subacute               |                                              1        1  2  1            |             
      Mixed Cell Focus                     |                                                                          |             
      Centrilobular, Necrosis              |                                                                          |             
      Hepatocyte, Vacuolization Cytoplasmic|                                     2                                    |             
      Kupffer Cell, Hyperplasia            |                   3                                            2         |             
      Kupffer Cell, Pigmentation           |                   3                                      2               |             
      Lobules, Necrosis                    |                   1                                                      |             
                                            __________________________________________________________________________|             
   Mesentery                               |                         +                    +                 +         |             
      Fat, Necrosis                        |                                              3                 4         |             
                                            __________________________________________________________________________|             
   Pancreas                                |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Cyst                                 |                                                                          |             
      Cytoplasmic Alteration               |                         3           4                             3      |             
      Hyperplasia, Lymphoid                |                                                       2                  |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                      1                          1     2        1        1|             
                                            __________________________________________________________________________|             
   Stomach                                 |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mucosa, Hyperplasia                  |                                                 1                        |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                X        X        X           X                       X  X|             
      Erosion                              |                                     3                                    |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 101                                                               
NTP Experiment-Test: 05089-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 15:57:00  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 7| 7| 7| 6| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 5| 5| 5| 5| 5| 0| 1| 3| 4| 3| 0| 3| 0| 8| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3|             
                                           | 5| 6| 7| 6| 5| 7| 7| 6| 0| 6| 8| 8| 1| 4| 8| 8| 8| 6| 0| 6| 6| 6| 1| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
                               ANIMAL ID   | 8| 8| 8| 8| 9| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9|             
    0.00700%                               | 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Ulcer                                |                                                                          |             
      Mucosa, Hyperplasia                  |                                                                         3|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Myocardium, Mineralization           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                   X        X           X     X  X        X     X        X|             
      Clear Cell Focus                     |                                                             X            |             
      Hyperplasia, Focal                   |                               3                                          |             
      Capsule, Hyperplasia                 |                                        2                 2               |             
      X-Zone, Degeneration, Fatty          |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                              1                           |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |                +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                                                    1                     |             
      Pars Distalis, Hyperplasia           |                                                    1                    1|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 |                3              2     3  2                 3     2     2  2|             
      Hyperplasia, Lymphoid                |                                                             2  1         |             
      Inflammation, Subacute               |                                                                          |             
      Follicle, Cyst                       |                                                 X                        |             
      Follicular Cell, Hyperplasia         |                         2  3     1           3  3  1  1        3         |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   |                I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                         2              2  3           3  4  3           4|             
      Cyst                                 |                         X        X        X        X        X  X  X      |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                3                                                         |             
      Hydrometra                           |                4        3  2           3  4     4  2        4  2     2   |             
      Hyperplasia, Cystic                  | 2  3  2  2  2  2  3  1  2  2  2  2  1  2  2  3  3  2  2  3  2  2  2  2  2|             
      Hyperplasia, Histiocytic             |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                2     2   |             
      Metaplasia, Squamous                 |                      1                                                   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 102                                                               
NTP Experiment-Test: 05089-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 15:57:00  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 7| 7| 7| 6| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 5| 5| 5| 5| 5| 0| 1| 3| 4| 3| 0| 3| 0| 8| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3|             
                                           | 5| 6| 7| 6| 5| 7| 7| 6| 0| 6| 8| 8| 1| 4| 8| 8| 8| 6| 0| 6| 6| 6| 1| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
                               ANIMAL ID   | 8| 8| 8| 8| 9| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9|             
    0.00700%                               | 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hypercellularity                     |                3        2                             2                  |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                       3        2        3|             
      Hyperplasia, Plasma Cell             |                                                       3                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hemorrhage                           |                                  1                                       |             
      Hyperplasia, Lymphoid                |                3                                                         |             
      Hyperplasia, Plasma Cell             |                                                                          |             
      Lymphatic, Dilatation                |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                             3            |             
      Hematopoietic Cell Proliferation     |                   4     4        3                    3        2     1   |             
      Hemorrhage                           |                   4                                                      |             
      Pigmentation, Hemosiderin            |                                                                          |             
      Lymphoid Follicle, Atrophy           |                                                                          |             
      Lymphoid Follicle, Hyperplasia       |                                                                2     2  2|             
      Red Pulp, Hyperplasia                |                                                                         2|             
                                            __________________________________________________________________________|             
   Thymus                                  |                +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                           3                              |             
      Cyst                                 |                                  X        X                              |             
      Depletion Cellular                   |                                     3                             4     2|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                           3           3                  |             
      Exudate                              |                                                       X                  |             
      Inflammation, Chronic                |                               1           2           2                  |             
      Ulcer                                |                                                                          |             
      Subcutaneous Tissue, Edema           |                         3        3                                       |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperostosis                         |                3                          2  1                           |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                         +                                                |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page 103                                                               
NTP Experiment-Test: 05089-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 15:57:00  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 7| 7| 7| 6| 7| 7| 7| 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 5| 5| 5| 5| 5| 0| 1| 3| 4| 3| 0| 3| 0| 8| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3|             
                                           | 5| 6| 7| 6| 5| 7| 7| 6| 0| 6| 8| 8| 1| 4| 8| 8| 8| 6| 0| 6| 6| 6| 1| 3| 3|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 4| 4| 4| 4| 4| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
                               ANIMAL ID   | 8| 8| 8| 8| 9| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 9|             
    0.00700%                               | 6| 7| 8| 9| 0| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Inflammation, Chronic                |                                                 2                        |             
      Thalamus, Mineralization             |                2  2  2  3  1  1  2  1  2  2  2  3  2  1  2  2  3  1  1  2|             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                     3                             4      |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                                          1               |             
      Infiltration Cellular, Histiocyte    |                                           3              1               |             
      Thrombosis                           |                                     X                                    |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Exudate                              |                                  X                                       |             
      Glands, Hyperplasia, Cystic          |                                                          1               |             
                                            __________________________________________________________________________|             
   Trachea                                 |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                    +  +                  |             
      Hyperplasia, Focal                   |                                                    2                     |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |          +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Casts Protein                        |                            1        1           1                        |             
      Cyst                                 |                            X        X                                    |             
      Glomerulosclerosis                   |                                                          1               |             
      Hemorrhage                           |                               2                                          |             
      Hydronephrosis                       |                                                                1         |             
      Hyperplasia, Lymphoid                |                   1  1        2                 3  1        1  1        1|             
      Metaplasia, Osseous                  |                            2                                             |             
      Mineralization                       |                                                                   1      |             
      Interstitium, Pigmentation           |                                                                          |             
      Renal Tubule, Atrophy                |                                           1              1               |             
      Renal Tubule, Cytoplasmic Alteration |                         3                                                |             
      Renal Tubule, Dilatation             |                                                 2              2         |             
      Renal Tubule, Regeneration           |          1  1        1  2  2  2  1     1  1  1  1  1     1  1     1  1  1|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                                                          |             
      Edema                                |                                                                          |             
      Hyperplasia, Lymphoid                |                   1  1           1     1  3     1     2        2         |             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 104                                                               
NTP Experiment-Test: 05089-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 15:57:00  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 5| 4| 2| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 3| 3| 4| 3| 6| 5| 1| 5| 5| 5|                                            |            |
                                           | 3| 3| 2| 3| 4| 7| 1| 8| 7| 8|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 0| 0| 0| 0| 0| 1|                                            |      A     |
    0.00700%                               | 6| 7| 8| 9| 0| 6| 7| 8| 9| 0|                                            |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +     +                                                      |  51        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  M  +  +     +                                                      |  49        |
      Cyst                                 |                                                                          |      1     |
      Dilatation                           |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +     +                                                      |  51        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +     +                                                      |  51        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +     +                                                      |  51        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +     +                                                      |  50        |
      Erosion                              |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +     +                                                      |  51        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +     +                                                      |  51        |
      Erosion                              |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +     +                                                      |  51        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +     +                                                      |  51        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +     +                                                      |  51        |
      Angiectasis                          |                                                                          |      1  2.0|
      Basophilic Focus                     |                                                                          |      2  3.0|
      Clear Cell Focus                     |       X                                                                  |      4     |
      Eosinophilic Focus                   |                                                                          |      1     |
      Hematopoietic Cell Proliferation     |                                                                          |      2  3.5|
      Hyperplasia, Focal                   |    3                                                                     |     11  2.3|
      Hyperplasia, Lymphoid                |                                                                          |      3  1.3|
      Inflammation, Subacute               | 1           3                                                            |      9  1.3|
      Mixed Cell Focus                     |                                                                          |      1     |
      Centrilobular, Necrosis              |                   3                                                      |      1  3.0|
      Hepatocyte, Vacuolization Cytoplasmic|                                                                          |      1  2.0|
      Kupffer Cell, Hyperplasia            |             2     3                                                      |      5  2.6|
      Kupffer Cell, Pigmentation           |                                                                          |      2  2.5|
      Lobules, Necrosis                    |                                                                          |      3  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |          +                                                               |  10        |
      Fat, Necrosis                        |          3                                                               |      7  3.1|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +     +                                                      |  50        |
      Atrophy                              |                                                                          |      1  2.0|
      Cyst                                 |                                                                          |      1     |
      Cytoplasmic Alteration               |                                                                          |      5  3.4|
      Hyperplasia, Lymphoid                |    1     1                                                               |      6  1.3|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +     +                                                      |  51        |
      Hyperplasia, Lymphoid                |    1     1                                                               |     11  1.2|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +     +                                                      |  51        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 105                                                               
NTP Experiment-Test: 05089-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 15:57:00  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 5| 4| 2| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 3| 3| 4| 3| 6| 5| 1| 5| 5| 5|                                            |            |
                                           | 3| 3| 2| 3| 4| 7| 1| 8| 7| 8|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 0| 0| 0| 0| 0| 1|                                            |      A     |
    0.00700%                               | 6| 7| 8| 9| 0| 6| 7| 8| 9| 0|                                            |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +     +                                                      |  51        |
      Mucosa, Hyperplasia                  |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +     +                                                      |  51        |
      Cyst                                 |                                                                          |     13     |
      Erosion                              |                                                                          |      2  3.5|
      Ulcer                                |                                                                          |      1  3.0|
      Mucosa, Hyperplasia                  |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +     +                                                      |  51        |
      Myocardium, Mineralization           |                   3                                                      |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +     +                                                      |  51        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +     +                                                      |  51        |
      Accessory Adrenal Cortical Nodule    | X     X                                                                  |     18     |
      Clear Cell Focus                     |                                                                          |      2     |
      Hyperplasia, Focal                   |                                                                          |      4  2.0|
      Capsule, Hyperplasia                 |                                                                          |      3  2.3|
      X-Zone, Degeneration, Fatty          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +     +                                                      |  51        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +     +                                                      |  50        |
      Hyperplasia                          |    1     2                                                               |      5  1.2|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +     +                                                      |  50        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +     +                                                      |  50        |
      Pars Distalis, Angiectasis           |                                                                          |      2  1.5|
      Pars Distalis, Hyperplasia           |                                                                          |      7  1.3|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +     +                                                      |  51        |
      Degeneration, Cystic                 |          2                                                               |     26  2.2|
      Hyperplasia, Lymphoid                |                                                                          |      3  1.7|
      Inflammation, Subacute               |                                                                          |      2  1.0|
      Follicle, Cyst                       |                                                                          |      1     |
      Follicular Cell, Hyperplasia         |    1     2                                                               |     17  1.8|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 106                                                               
NTP Experiment-Test: 05089-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 15:57:00  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 5| 4| 2| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 3| 3| 4| 3| 6| 5| 1| 5| 5| 5|                                            |            |
                                           | 3| 3| 2| 3| 4| 7| 1| 8| 7| 8|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 0| 0| 0| 0| 0| 1|                                            |      A     |
    0.00700%                               | 6| 7| 8| 9| 0| 6| 7| 8| 9| 0|                                            |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +     +                                                      |  46        |
      Angiectasis                          | 2  4                                                                     |     15  2.6|
      Cyst                                 |       X     X                                                            |     14     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Angiectasis                          |          3                                                               |      4  2.8|
      Hydrometra                           |                            2                                             |     19  3.1|
      Hyperplasia, Cystic                  | 3  3  2  2  2  2     2  2  1                                             |     58  2.2|
      Hyperplasia, Histiocytic             |       4                                                                  |      1  4.0|
      Hyperplasia, Lymphoid                |                                                                          |      3  1.7|
      Metaplasia, Squamous                 |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +     +                                                      |  51        |
      Hypercellularity                     |             3                                                            |      5  2.4|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +     +                                                      |  51        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | M  +  +  +  +     +                                                      |  49        |
      Hyperplasia, Lymphoid                |                                                                          |      4  2.5|
      Hyperplasia, Plasma Cell             |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  M  +  +     +                                                      |  47        |
      Hematopoietic Cell Proliferation     | 2                                                                        |      1  2.0|
      Hemorrhage                           | 1        1                                                               |      4  1.5|
      Hyperplasia, Lymphoid                |                                                                          |      2  2.5|
      Hyperplasia, Plasma Cell             |                                                                          |      1  2.0|
      Lymphatic, Dilatation                |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +     +                                                      |  51        |
      Congestion                           |                                                                          |      1  3.0|
      Hematopoietic Cell Proliferation     |          1  3     3                                                      |     17  2.5|
      Hemorrhage                           |                                                                          |      1  4.0|
      Pigmentation, Hemosiderin            |          2                                                               |      3  2.0|
      Lymphoid Follicle, Atrophy           |                                                                          |      1  3.0|
      Lymphoid Follicle, Hyperplasia       |                                                                          |      6  2.2|
      Red Pulp, Hyperplasia                |             3                                                            |      2  2.5|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  I  +  +     +                                                      |  49        |
      Angiectasis                          |                                                                          |      1  3.0|
      Cyst                                 |                                                                          |      5     |
      Depletion Cellular                   |             2     3                                                      |     10  2.7|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +     +                                                      |  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 107                                                               
NTP Experiment-Test: 05089-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 15:57:00  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 5| 4| 2| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 3| 3| 4| 3| 6| 5| 1| 5| 5| 5|                                            |            |
                                           | 3| 3| 2| 3| 4| 7| 1| 8| 7| 8|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 0| 0| 0| 0| 0| 1|                                            |      A     |
    0.00700%                               | 6| 7| 8| 9| 0| 6| 7| 8| 9| 0|                                            |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia, Cystic                  |                                                                          |      3  1.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +     +                                                      |  51        |
      Acanthosis                           |                                                                          |      3  2.7|
      Exudate                              |                                                                          |      1     |
      Inflammation, Chronic                | 1                                                                        |      4  1.5|
      Ulcer                                |                                                                          |      1  4.0|
      Subcutaneous Tissue, Edema           |             3                                                            |      3  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +     +                                                      |  51        |
      Hyperostosis                         |                                                                          |      7  2.0|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |             +                                                            |   3        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +     +                                                      |  51        |
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Thalamus, Mineralization             | 3  2  2     1                                                            |     45  2.0|
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +     +                                                      |  51        |
      Congestion                           |       3                                                                  |      3  3.3|
      Hemorrhage                           |       2                                                                  |      4  2.0|
      Hyperplasia, Lymphoid                |                                                                          |      9  1.7|
      Infiltration Cellular, Histiocyte    |    3                                                                     |      7  2.7|
      Thrombosis                           |                                                                          |      1     |
      Alveolar Epithelium, Hyperplasia     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +     +                                                      |  51        |
      Exudate                              |    X                                                                     |      5     |
      Glands, Hyperplasia, Cystic          |    2                                                                     |      7  1.3|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +     +                                                      |  51        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |    +                                                                     |   3        |
      Hyperplasia, Focal                   |    3                                                                     |      2  2.5|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  57        |
      Casts Protein                        | 1                                                                        |     10  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 108                                                               
NTP Experiment-Test: 05089-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 15:57:00  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 7| 5| 4| 2| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 3| 3| 4| 3| 6| 5| 1| 5| 5| 5|                                            |            |
                                           | 3| 3| 2| 3| 4| 7| 1| 8| 7| 8|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 1| 1| 1| 1| 1| 1|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 9| 9| 9| 9| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 0| 0| 0| 0| 0| 1|                                            |      A     |
    0.00700%                               | 6| 7| 8| 9| 0| 6| 7| 8| 9| 0|                                            |      L     |
                                           | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Cyst                                 |                                                                          |      6     |
      Glomerulosclerosis                   |                                                                          |      3  1.0|
      Hemorrhage                           |                                                                          |      1  2.0|
      Hydronephrosis                       |                                                                          |      2  1.0|
      Hyperplasia, Lymphoid                |    2                                                                     |     15  1.4|
      Metaplasia, Osseous                  |                                                                          |      2  1.5|
      Mineralization                       |                                                                          |      6  1.0|
      Interstitium, Pigmentation           |                                                                          |      1  2.0|
      Renal Tubule, Atrophy                |                                                                          |      4  2.0|
      Renal Tubule, Cytoplasmic Alteration |                                                                          |      1  3.0|
      Renal Tubule, Dilatation             |                                                                          |      3  2.0|
      Renal Tubule, Regeneration           | 1  1     1     1     1  1  2                                             |     40  1.2|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +     +                                                      |  50        |
      Dilatation                           |                                                                          |      1  4.0|
      Edema                                |                                                                          |      1  3.0|
      Hyperplasia, Lymphoid                |    1  1  1                                                               |     18  1.4|
      Inflammation, Chronic                |                                                                          |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 109                                                               
NTP Experiment-Test: 05089-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 15:57:00  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 5| 7| 7| 7| 5| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 5| 7| 7| 5| 7| 7|             
                             DAY ON TEST   | 3| 3| 4| 3| 3| 3| 5| 3| 2| 3| 3| 3| 9| 3| 3| 3| 3| 3| 2| 5| 3| 3| 5| 3| 3|             
                                           | 3| 3| 1| 3| 3| 3| 8| 6| 5| 6| 6| 6| 1| 6| 6| 6| 6| 6| 7| 1| 5| 5| 9| 6| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2|             
    VEHICLE                                | 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5| 6| 7| 8| 9| 0| 1| 2| 3| 4| 5|             
    CONTROL                                | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum