National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/1188

TR 392 Rat Pathology Tables

NTP Experiment-Test: 05089-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97
Route: DOSED WATER                                                                                                Time: 12:36:25




       Facility:  Southern Research Institute

       Chemical CAS #:  10599903

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    25019 Moribund Sacrifice                25020 Natural Death
                               25021 Terminal Sacrifice

       Removal Date Range:     All

       Treatment Groups:       Merge     001   001,002                  0 ppm
                               Merge     002   003,004                  0 ppm
                               Merge     003   013,014                  50 ppm
                               Merge     004   015,016                  50 ppm
                               Merge     005   009,010                  100 ppm
                               Merge     006   011,012                  100 ppm
                               Merge     007   005,006                  200 ppm
                               Merge     008   007,008                  200 ppm




























a  Number of animals examined microscopically at site and number of animals with lesion

                                                              Page   1


NTP Experiment-Test: 05089-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 12:36:25  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   0 ppm        50 ppm       100 ppm      200 ppm                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 

  Animals Initially In Study                          70           70           70           70                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                16           17           20           23                                     
    Natural Death                                      3            5            1            3                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                31           28           29           24                                     

  Animals Examined Microscopically                    50           50           50           50                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (50)         (50)         (50)         (50)                                   
      Inflammation, Chronic                                         1 (2%)                                                          
      Necrosis                                                      1 (2%)                                                          
      Parasite Metazoan                                1 (2%)       2 (4%)       3 (6%)                                             
      Perforation                                                   1 (2%)                                                          
   Intestine Large, Rectum                            (50)         (50)         (50)         (50)                                   
      Parasite Metazoan                                4 (8%)       4 (8%)       3 (6%)       4 (8%)                                
   Liver                                              (50)         (50)         (50)         (50)                                   
      Angiectasis                                      3 (6%)       2 (4%)       3 (6%)       2 (4%)                                
      Basophilic Focus                                 1 (2%)                                                                       
      Congestion                                       3 (6%)       1 (2%)                    1 (2%)                                
      Cyst                                                                       1 (2%)                                             
      Fatty Change                                    10 (20%)     17 (34%)     13 (26%)     11 (22%)                               
      Fibrosis, Focal                                  1 (2%)                                                                       
      Focal Cellular Change                           36 (72%)     35 (70%)     32 (64%)     30 (60%)                               
      Granuloma                                       39 (78%)     38 (76%)     36 (72%)     36 (72%)                               
      Hematopoietic Cell Proliferation                 6 (12%)      2 (4%)       3 (6%)       2 (4%)                                
      Hemorrhage                                       1 (2%)                                                                       
      Hepatodiaphragmatic Nodule                      10 (20%)      5 (10%)      6 (12%)      7 (14%)                               
      Hyperplasia, Histiocytic, Lymphoid               1 (2%)       1 (2%)                    2 (4%)                                
      Hyperplasia, Multifocal                          7 (14%)      6 (12%)      8 (16%)     15 (30%)                               
      Infiltration Cellular, Mixed Cell                4 (8%)      11 (22%)      3 (6%)       9 (18%)                               
      Inflammation, Focal                                                                     1 (2%)                                
      Necrosis, Focal                                  1 (2%)       3 (6%)       1 (2%)       3 (6%)                                
      Bile Duct, Hyperplasia                          34 (68%)     32 (64%)     35 (70%)     35 (70%)                               
      Biliary Tract, Fibrosis                         28 (56%)     27 (54%)     26 (52%)     24 (48%)                               
      Centrilobular, Atrophy                           4 (8%)       7 (14%)      4 (8%)       9 (18%)                               
      Centrilobular, Necrosis                                                    1 (2%)       2 (4%)                                
      Serosa, Fibrosis                                              1 (2%)                                                          
   Mesentery                                          (10)         (11)         (5)          (9)                                    
      Accessory Spleen                                 1 (10%)      1 (9%)                                                          
      Infiltration Cellular, Lymphocyte                1 (10%)                                                                      
      Inflammation, Chronic                            5 (50%)      6 (55%)      3 (60%)      1 (11%)                               
      Fat, Necrosis                                    2 (20%)      2 (18%)      1 (20%)      3 (33%)                               

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    2                                                              
NTP Experiment-Test: 05089-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 12:36:25  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   0 ppm        50 ppm       100 ppm      200 ppm                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
   Pancreas                                           (50)         (50)         (49)         (50)                                   
      Atrophy, Focal                                   6 (12%)      6 (12%)      7 (14%)      4 (8%)                                
      Cytoplasmic Alteration                           1 (2%)       1 (2%)                                                          
      Edema                                                                      1 (2%)                                             
      Duct, Dilatation                                                                        1 (2%)                                
   Salivary Glands                                    (49)         (50)         (50)         (50)                                   
      Focal Cellular Change                            1 (2%)                                                                       
      Inflammation, Chronic                            1 (2%)                                                                       
      Mineralization                                                                          1 (2%)                                
   Stomach, Forestomach                               (50)         (50)         (50)         (49)                                   
      Cyst                                                                       1 (2%)                                             
      Edema                                                                      1 (2%)                                             
      Erosion                                          1 (2%)                                                                       
      Hyperplasia, Basal Cell                                       1 (2%)                                                          
      Inflammation, Chronic                            7 (14%)      3 (6%)       5 (10%)      5 (10%)                               
      Perforation                                      2 (4%)       1 (2%)       1 (2%)       1 (2%)                                
      Ulcer                                            6 (12%)      2 (4%)       3 (6%)       4 (8%)                                
      Mucosa, Hyperplasia, Papillary                   9 (18%)      2 (4%)       5 (10%)      6 (12%)                               
   Stomach, Glandular                                 (50)         (50)         (50)         (50)                                   
      Edema                                                                      1 (2%)                                             
      Erosion                                          1 (2%)                    1 (2%)                                             
      Inflammation, Chronic                            2 (4%)       1 (2%)       2 (4%)       1 (2%)                                
      Mucosa, Hyperplasia                                                        1 (2%)                                             
   Tongue                                             (1)          (1)          (1)                                                 
      Hyperplasia, Squamous                                         1 (100%)                                                        
   Tooth                                              (1)                                                                           
      Dysplasia                                        1 (100%)                                                                     
      Inflammation, Suppurative                        1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                                    (1)                                                              
      Mesenteric Artery, Inflammation, Chronic                      1 (100%)                                                        
   Heart                                              (50)         (50)         (50)         (50)                                   
      Thrombosis                                                                 2 (4%)                                             
      Artery, Inflammation, Chronic                    1 (2%)       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (50)         (50)         (50)                                   
      Accessory Adrenal Cortical Nodule                1 (2%)                                                                       
      Angiectasis                                                   2 (4%)       1 (2%)                                             
      Congestion                                       1 (2%)       2 (4%)       1 (2%)                                             
      Degeneration                                                               1 (2%)                                             
      Fibrosis                                                                   1 (2%)                                             

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    3                                                              
NTP Experiment-Test: 05089-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 12:36:25  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   0 ppm        50 ppm       100 ppm      200 ppm                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Focal Cellular Change                           16 (32%)     14 (28%)     14 (28%)     16 (32%)                               
      Hyperplasia                                                                             2 (4%)                                
      Necrosis                                                      1 (2%)                                                          
      Vacuolization Cytoplasmic                        1 (2%)       3 (6%)       2 (4%)       1 (2%)                                
   Adrenal Gland, Medulla                             (50)         (49)         (50)         (50)                                   
      Developmental Malformation                                    1 (2%)                                                          
      Hyperplasia                                      5 (10%)      6 (12%)      6 (12%)      9 (18%)                               
      Infiltration Cellular, Lymphocyte                                                       1 (2%)                                
   Parathyroid Gland                                  (49)         (47)         (50)         (50)                                   
      Hyperplasia                                                                             1 (2%)                                
   Pituitary Gland                                    (50)         (49)         (50)         (50)                                   
      Angiectasis                                     38 (76%)     40 (82%)     36 (72%)     40 (80%)                               
      Cyst                                             3 (6%)       1 (2%)       4 (8%)       3 (6%)                                
      Hemorrhage                                                    1 (2%)                    1 (2%)                                
      Pars Distalis, Hyperplasia, Focal                6 (12%)      6 (12%)      9 (18%)      2 (4%)                                
   Thyroid Gland                                      (50)         (50)         (50)         (50)                                   
      Degeneration, Cystic                             3 (6%)                                                                       
      Ultimobranchial Cyst                             1 (2%)                                                                       
      C-Cell, Hyperplasia                              7 (14%)      8 (16%)     11 (22%)      4 (8%)                                
      Follicle, Cyst                                   1 (2%)                                                                       
      Follicular Cell, Hyperplasia                     2 (4%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                         (1)          (2)                                                              
      Abdominal, Hemorrhage                                         1 (50%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (48)         (50)         (50)         (49)                                   
      Degeneration, Cystic                             1 (2%)       1 (2%)       2 (4%)       1 (2%)                                
      Hyperplasia                                      3 (6%)       4 (8%)       6 (12%)      3 (6%)                                
      Inflammation, Suppurative                       11 (23%)      8 (16%)      9 (18%)      5 (10%)                               
   Ovary                                              (50)         (50)         (50)         (50)                                   
      Angiectasis                                                                             1 (2%)                                
      Corpus Luteum, Proliferation                     1 (2%)                                 1 (2%)                                
      Corpus Luteum, Thecal Cell, Hyperplasia          1 (2%)       1 (2%)                    1 (2%)                                
      Follicle, Cyst                                   2 (4%)                    1 (2%)       2 (4%)                                
      Periovarian Tissue, Cyst                                      1 (2%)       1 (2%)       2 (4%)                                
   Uterus                                             (50)         (50)         (50)         (50)                                   
      Cyst                                                                                    1 (2%)                                
      Decidual Reaction                                                          1 (2%)                                             
      Hemorrhage                                       2 (4%)                                                                       
      Hydrometra                                       2 (4%)       1 (2%)       5 (10%)      5 (10%)                               
      Inflammation, Suppurative                                                  2 (4%)       2 (4%)                                

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    4                                                              
NTP Experiment-Test: 05089-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 12:36:25  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   0 ppm        50 ppm       100 ppm      200 ppm                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Cervix, Lamina Propria, Hyperplasia                                                     1 (2%)                                
      Endometrium, Hyperplasia, Cystic                26 (52%)     32 (64%)     38 (76%)     18 (36%)                               
      Horn, Atrophy                                                                           1 (2%)                                
   Vagina                                             (8)          (7)          (11)         (12)                                   
      Cyst                                             6 (75%)      6 (86%)     10 (91%)      7 (58%)                               
      Inflammation, Suppurative                        2 (25%)      4 (57%)      8 (73%)      2 (17%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (50)         (50)         (50)         (50)                                   
      Hypercellularity                                 4 (8%)       7 (14%)      5 (10%)      5 (10%)                               
      Myelofibrosis                                    1 (2%)       1 (2%)                                                          
   Lymph Node                                         (50)         (50)         (50)         (50)                                   
      Inguinal, Angiectasis                                                                   1 (2%)                                
      Inguinal, Hyperplasia                                                      3 (6%)       2 (4%)                                
      Inguinal, Inflammation, Suppurative                                                     1 (2%)                                
      Mediastinal, Angiectasis                         3 (6%)       3 (6%)       7 (14%)      7 (14%)                               
      Mediastinal, Hyperplasia                                                   1 (2%)                                             
      Pancreatic, Angiectasis                          1 (2%)                    3 (6%)       1 (2%)                                
      Pancreatic, Hyperplasia, Histiocytic                          1 (2%)                                                          
      Renal, Angiectasis                                                                      2 (4%)                                
   Lymph Node, Mandibular                             (48)         (49)         (49)         (49)                                   
      Angiectasis                                      3 (6%)       1 (2%)       3 (6%)       2 (4%)                                
      Hyperplasia                                      5 (10%)      1 (2%)       3 (6%)       1 (2%)                                
      Hyperplasia, Lymphoid                            1 (2%)                                                                       
   Lymph Node, Mesenteric                             (49)         (50)         (50)         (50)                                   
      Angiectasis                                      2 (4%)       1 (2%)       3 (6%)       3 (6%)                                
      Hyperplasia                                                   1 (2%)                                                          
      Hyperplasia, Lymphoid                                         1 (2%)                                                          
   Spleen                                             (50)         (50)         (50)         (50)                                   
      Depletion Cellular                                            1 (2%)       2 (4%)                                             
      Developmental Malformation                                                 1 (2%)                                             
      Fibrosis                                                      1 (2%)       1 (2%)       1 (2%)                                
      Hematopoietic Cell Proliferation                12 (24%)      8 (16%)      7 (14%)      9 (18%)                               
      Hyperplasia, Histiocytic, Lymphoid               2 (4%)       4 (8%)       2 (4%)       6 (12%)                               
      Necrosis, Focal                                                            1 (2%)                                             
      Capsule, Hyperplasia, Histiocytic, Lymphoid      1 (2%)                                                                       
   Thymus                                             (49)         (47)         (49)         (49)                                   
      Cyst                                                          3 (6%)       2 (4%)                                             
      Epithelial Cell, Hyperplasia                                               1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    5                                                              
NTP Experiment-Test: 05089-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 12:36:25  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   0 ppm        50 ppm       100 ppm      200 ppm                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (50)         (50)         (50)         (50)                                   
      Dilatation                                      40 (80%)     43 (86%)     40 (80%)     38 (76%)                               
      Fibrosis                                                                   1 (2%)                                             
      Hyperplasia                                      3 (6%)       3 (6%)       5 (10%)      7 (14%)                               
      Inflammation, Suppurative                                     1 (2%)                                                          
   Skin                                               (50)         (50)         (50)         (50)                                   
      Abscess                                          1 (2%)                                                                       
      Erosion                                                                    1 (2%)                                             
      Exudate                                                                    1 (2%)                                             
      Hemorrhage                                                                 1 (2%)                                             
      Hyperkeratosis                                                1 (2%)                                                          
      Inflammation, Chronic                            3 (6%)       1 (2%)       2 (4%)       1 (2%)                                
      Ulcer                                            2 (4%)                    1 (2%)       1 (2%)                                
      Epidermis, Hyperplasia                                        1 (2%)                                                          
      Sebaceous Gland, Cyst                                                      1 (2%)                                             
      Subcutaneous Tissue, Foreign Body                                          1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (50)         (50)         (50)         (50)                                   
      Hyperostosis                                     9 (18%)      6 (12%)     11 (22%)      9 (18%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (48)         (50)         (49)         (50)                                   
      Compression                                     11 (23%)     16 (32%)      5 (10%)      7 (14%)                               
      Hemorrhage                                                    2 (4%)                    3 (6%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (50)         (50)         (50)                                   
      Congestion                                                    3 (6%)       1 (2%)       1 (2%)                                
      Foreign Body                                     1 (2%)                                                                       
      Hemorrhage                                       1 (2%)       3 (6%)       1 (2%)       2 (4%)                                
      Hyperplasia, Macrophage                          3 (6%)       1 (2%)       2 (4%)       3 (6%)                                
      Infiltration Cellular, Mixed Cell                3 (6%)                                 4 (8%)                                
      Inflammation, Acute                                           1 (2%)                                                          
      Inflammation, Pyogranulomatous                   1 (2%)                                                                       
      Alveolar Epithelium, Hyperplasia                 2 (4%)                    4 (8%)       4 (8%)                                
   Nose                                               (50)         (50)         (50)         (50)                                   
      Foreign Body                                     1 (2%)                                                                       
      Fungus                                           3 (6%)       7 (14%)      3 (6%)       3 (6%)                                
      Inflammation, Suppurative                        3 (6%)       8 (16%)      3 (6%)       4 (8%)                                

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    6                                                              
NTP Experiment-Test: 05089-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 12:36:25  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS FEMALE                   0 ppm        50 ppm       100 ppm      200 ppm                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (3)          (1)          (5)          (6)                                    
      Atrophy                                                                                 2 (33%)                               
      Cataract                                         3 (100%)                  4 (80%)      4 (67%)                               
      Hemorrhage                                                                 1 (20%)                                            
      Cornea, Inflammation, Acute                                   1 (100%)                                                        
      Retina, Degeneration                             2 (67%)                   3 (60%)      6 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)         (50)                                   
      Atrophy                                                                    1 (2%)       1 (2%)                                
      Cyst                                                                                    3 (6%)                                
      Fibrosis                                                      1 (2%)                                                          
      Hydronephrosis                                                                          1 (2%)                                
      Inflammation, Suppurative                                     1 (2%)       1 (2%)       1 (2%)                                
      Mineralization                                   2 (4%)       2 (4%)       2 (4%)                                             
      Nephropathy                                     46 (92%)     48 (96%)     50 (100%)    49 (98%)                               
      Pigmentation                                                  1 (2%)       1 (2%)                                             
      Pelvis, Transitional Epithelium, Hyperplasia                               1 (2%)       1 (2%)                                
      Renal Tubule, Vacuolization Cytoplasmic          1 (2%)                                                                       
   Urinary Bladder                                    (50)         (50)         (50)         (50)                                   
      Hemorrhage                                                                 1 (2%)                                             
      Inflammation, Chronic                                                      1 (2%)                                             
      Transitional Epithelium, Hyperplasia                          1 (2%)       1 (2%)                                             
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    7                                                              
NTP Experiment-Test: 05089-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 12:36:25  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     0 ppm        50 ppm       100 ppm      200 ppm                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________

DISPOSITION SUMMARY                                                                                                                 

  Animals Initially In Study                          70           70           70           70                                     
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                34           27           34           33                                     
    Natural Death                                      3            1            3            1                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                14           22           14           16                                     

  Animals Examined Microscopically                    51           50           51           50                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (51)         (50)         (50)         (50)                                   
      Edema                                            1 (2%)                                                                       
      Hemorrhage                                       1 (2%)                                                                       
      Inflammation, Chronic                            1 (2%)                                                                       
      Parasite Metazoan                                             1 (2%)       1 (2%)                                             
   Intestine Large, Colon                             (51)         (50)         (51)         (49)                                   
      Parasite Metazoan                                1 (2%)       3 (6%)       2 (4%)       1 (2%)                                
   Intestine Large, Rectum                            (51)         (50)         (50)         (49)                                   
      Parasite Metazoan                                5 (10%)      4 (8%)       1 (2%)       3 (6%)                                
   Intestine Small, Ileum                             (51)         (50)         (51)         (49)                                   
      Cyst                                                                                    1 (2%)                                
   Intestine Small, Jejunum                           (51)         (50)         (51)         (49)                                   
      Metaplasia, Osseous                              1 (2%)                                                                       
   Liver                                              (51)         (50)         (51)         (50)                                   
      Angiectasis                                      8 (16%)      3 (6%)       6 (12%)      2 (4%)                                
      Atrophy, Focal                                   1 (2%)                                                                       
      Basophilic Focus                                 1 (2%)                                 1 (2%)                                
      Congestion                                       1 (2%)       2 (4%)       1 (2%)                                             
      Degeneration, Cystic                            10 (20%)     14 (28%)     10 (20%)      5 (10%)                               
      Eosinophilic Focus                                                         1 (2%)       2 (4%)                                
      Fatty Change                                    14 (27%)     21 (42%)     17 (33%)     14 (28%)                               
      Focal Cellular Change                           11 (22%)     12 (24%)     13 (25%)     13 (26%)                               
      Hemorrhage                                       3 (6%)                    1 (2%)                                             
      Hepatodiaphragmatic Nodule                       5 (10%)      4 (8%)       3 (6%)       4 (8%)                                
      Hyperplasia                                                   2 (4%)                                                          
      Hyperplasia, Multifocal                         15 (29%)     19 (38%)     22 (43%)     12 (24%)                               
      Infiltration Cellular, Mixed Cell                7 (14%)      4 (8%)      10 (20%)     12 (24%)                               
      Inflammation, Focal                             18 (35%)     24 (48%)     20 (39%)     18 (36%)                               
      Mineralization                                   1 (2%)                                                                       
      Mixed Cell Focus                                              2 (4%)                    1 (2%)                                
      Necrosis, Focal                                  2 (4%)       2 (4%)       3 (6%)       1 (2%)                                
      Thrombosis                                                    1 (2%)       2 (4%)       2 (4%)                                
      Bile Duct, Dilatation                                                      1 (2%)                                             
      Bile Duct, Hyperplasia                          48 (94%)     50 (100%)    49 (96%)     49 (98%)                               

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    8                                                              
NTP Experiment-Test: 05089-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 12:36:25  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     0 ppm        50 ppm       100 ppm      200 ppm                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Biliary Tract, Fibrosis                         42 (82%)     48 (96%)     47 (92%)     44 (88%)                               
      Centrilobular, Atrophy                          14 (27%)     15 (30%)     15 (29%)     13 (26%)                               
   Mesentery                                          (31)         (15)         (15)         (24)                                   
      Hemorrhage                                       1 (3%)       1 (7%)       1 (7%)                                             
      Inflammation, Chronic                            7 (23%)      4 (27%)      3 (20%)      3 (13%)                               
      Fat, Necrosis                                   11 (35%)      3 (20%)      6 (40%)     12 (50%)                               
   Pancreas                                           (51)         (50)         (51)         (50)                                   
      Accessory Spleen                                                                        2 (4%)                                
      Atrophy, Diffuse                                                                        1 (2%)                                
      Atrophy, Focal                                  13 (25%)     18 (36%)     14 (27%)     16 (32%)                               
      Cytoplasmic Alteration                           1 (2%)       1 (2%)       1 (2%)                                             
      Edema                                                                                   1 (2%)                                
      Inflammation, Chronic                                                      1 (2%)                                             
      Acinar Cell, Hyperplasia                         3 (6%)       1 (2%)                                                          
      Duct, Dilatation                                              3 (6%)                    1 (2%)                                
   Salivary Glands                                    (51)         (50)         (51)         (50)                                   
      Infiltration Cellular, Lipocyte                               1 (2%)                                                          
   Stomach, Forestomach                               (51)         (50)         (51)         (49)                                   
      Hyperplasia, Squamous                                         1 (2%)       1 (2%)                                             
      Inflammation, Chronic                            7 (14%)      7 (14%)      4 (8%)       5 (10%)                               
      Mineralization                                                1 (2%)       1 (2%)                                             
      Perforation                                                   1 (2%)       1 (2%)                                             
      Ulcer                                            6 (12%)      4 (8%)       2 (4%)       1 (2%)                                
      Mucosa, Hyperplasia, Papillary                   6 (12%)      6 (12%)      7 (14%)      6 (12%)                               
   Stomach, Glandular                                 (51)         (50)         (51)         (49)                                   
      Edema                                                                      1 (2%)       1 (2%)                                
      Erosion                                          3 (6%)       2 (4%)       2 (4%)                                             
      Inflammation, Chronic                            8 (16%)      2 (4%)       3 (6%)       2 (4%)                                
      Mineralization                                   1 (2%)       3 (6%)       1 (2%)                                             
      Pigmentation, Focal                              2 (4%)                                                                       
      Ulcer                                            1 (2%)                    1 (2%)                                             
      Epithelium, Degeneration, Hyaline                             1 (2%)                                                          
      Mucosa, Cyst                                                                            1 (2%)                                
      Mucosa, Hyperplasia                              1 (2%)                                                                       
   Tooth                                              (2)                                    (1)                                    
      Epithelium Alveolus, Cyst                        1 (50%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (5)          (4)          (2)                                                 
      Aorta, Mineralization                            1 (20%)                                                                      
      Mesenteric Artery, Hypertrophy                                1 (25%)                                                         
      Mesenteric Artery, Inflammation, Chronic         4 (80%)      4 (100%)     2 (100%)                                           
      Mesenteric Artery, Mineralization                1 (20%)      1 (25%)                                                         
   Heart                                              (51)         (50)         (51)         (50)                                   
      Mineralization                                                             1 (2%)                                             

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page    9                                                              
NTP Experiment-Test: 05089-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 12:36:25  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     0 ppm        50 ppm       100 ppm      200 ppm                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
CARDIOVASCULAR SYSTEM - CONT                                                                                                        
      Thrombosis                                                    1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (51)         (50)         (51)         (50)                                   
      Angiectasis                                                                             1 (2%)                                
      Cyst                                             1 (2%)                                                                       
      Focal Cellular Change                           13 (25%)     22 (44%)     11 (22%)     10 (20%)                               
      Hematopoietic Cell Proliferation                                           1 (2%)                                             
      Hemorrhage                                       1 (2%)                                                                       
      Mineralization                                                             2 (4%)                                             
      Necrosis                                         1 (2%)       1 (2%)       1 (2%)                                             
      Vacuolization Cytoplasmic                                     2 (4%)       2 (4%)                                             
   Adrenal Gland, Medulla                             (51)         (50)         (51)         (50)                                   
      Cyst                                                                                    1 (2%)                                
      Hemorrhage                                       1 (2%)                                                                       
      Hyperplasia                                     10 (20%)     12 (24%)      9 (18%)     11 (22%)                               
      Necrosis                                         1 (2%)                                                                       
   Islets, Pancreatic                                 (51)         (50)         (51)         (50)                                   
      Hyperplasia                                                                1 (2%)                                             
   Parathyroid Gland                                  (50)         (48)         (49)         (50)                                   
      Hyperplasia                                      4 (8%)       4 (8%)       1 (2%)                                             
   Pituitary Gland                                    (50)         (50)         (51)         (50)                                   
      Angiectasis                                     17 (34%)     23 (46%)     18 (35%)     21 (42%)                               
      Atrophy                                                                    1 (2%)                                             
      Cyst                                             2 (4%)       4 (8%)       3 (6%)       1 (2%)                                
      Hemorrhage                                                    3 (6%)                                                          
      Pigmentation                                     1 (2%)                                                                       
      Pars Distalis, Focal Cellular Change             1 (2%)                                                                       
      Pars Distalis, Hyperplasia                                                              1 (2%)                                
      Pars Distalis, Hyperplasia, Focal                8 (16%)      4 (8%)       7 (14%)      7 (14%)                               
      Pars Nervosa, Focal Cellular Change                                                     1 (2%)                                
   Thyroid Gland                                      (51)         (50)         (51)         (50)                                   
      Degeneration, Cystic                             6 (12%)      8 (16%)      4 (8%)       7 (14%)                               
      Pigmentation                                     1 (2%)                                                                       
      Ultimobranchial Cyst                             1 (2%)                                                                       
      C-Cell, Hyperplasia                              5 (10%)      4 (8%)       2 (4%)       5 (10%)                               
      Follicle, Cyst                                   1 (2%)                    2 (4%)                                             
      Follicular Cell, Hyperplasia                     1 (2%)       2 (4%)       2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page   10                                                              
NTP Experiment-Test: 05089-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 12:36:25  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     0 ppm        50 ppm       100 ppm      200 ppm                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (51)         (50)         (51)         (50)                                   
      Edema                                                                                   1 (2%)                                
      Inflammation, Chronic                                         1 (2%)       1 (2%)                                             
   Preputial Gland                                    (50)         (50)         (51)         (50)                                   
      Degeneration, Cystic                             3 (6%)       1 (2%)                                                          
      Fibrosis                                         1 (2%)                                                                       
      Hyperplasia                                                   2 (4%)       1 (2%)       1 (2%)                                
      Inflammation, Suppurative                       20 (40%)     23 (46%)     22 (43%)     23 (46%)                               
   Prostate                                           (51)         (50)         (51)         (50)                                   
      Degeneration, Cystic                                          1 (2%)                                                          
      Edema                                                                      1 (2%)                                             
      Hyperplasia, Focal                                            5 (10%)                   1 (2%)                                
      Inflammation, Suppurative                       28 (55%)     42 (84%)     31 (61%)     35 (70%)                               
   Seminal Vesicle                                    (51)         (50)         (51)         (50)                                   
      Dilatation                                                                              2 (4%)                                
      Inflammation, Chronic                            1 (2%)                    1 (2%)                                             
   Testes                                             (51)         (50)         (51)         (50)                                   
      Fibrosis                                         1 (2%)                                                                       
      Hyperplasia                                                   1 (2%)                                                          
      Artery, Inflammation, Chronic                                 1 (2%)       1 (2%)                                             
      Germinal Epithelium, Degeneration               15 (29%)     14 (28%)     14 (27%)     11 (22%)                               
      Interstitial Cell, Hyperplasia                  13 (25%)      9 (18%)     11 (22%)      9 (18%)                               
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (51)         (50)         (51)         (50)                                   
      Hypercellularity                                                           2 (4%)                                             
      Myelofibrosis                                    4 (8%)       2 (4%)       3 (6%)       1 (2%)                                
   Lymph Node                                         (51)         (50)         (51)         (50)                                   
      Bronchial, Hyperplasia                                                     1 (2%)                                             
      Iliac, Hyperplasia                                                         1 (2%)                                             
      Inguinal, Hyperplasia                                         1 (2%)       1 (2%)                                             
      Mediastinal, Angiectasis                         6 (12%)      3 (6%)       1 (2%)       1 (2%)                                
      Mediastinal, Hyperplasia                         1 (2%)       2 (4%)       1 (2%)                                             
      Mediastinal, Hyperplasia, Lymphoid                                         1 (2%)                                             
      Pancreatic, Angiectasis                                       1 (2%)                                                          
      Pancreatic, Hyperplasia                          2 (4%)                                                                       
      Pancreatic, Hyperplasia, Histiocytic                                                    1 (2%)                                
      Renal, Angiectasis                               1 (2%)       1 (2%)                                                          
      Renal, Hyperplasia                                                         1 (2%)                                             
   Lymph Node, Mandibular                             (51)         (50)         (51)         (49)                                   
      Angiectasis                                      3 (6%)       1 (2%)       2 (4%)                                             
      Cyst                                                                       1 (2%)                                             
      Hemorrhage                                                    1 (2%)                                                          
      Hyperplasia                                      4 (8%)       4 (8%)       9 (18%)      3 (6%)                                

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page   11                                                              
NTP Experiment-Test: 05089-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 12:36:25  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     0 ppm        50 ppm       100 ppm      200 ppm                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Hyperplasia, Lymphoid                                         1 (2%)                                                          
   Lymph Node, Mesenteric                             (51)         (49)         (51)         (50)                                   
      Angiectasis                                      1 (2%)       1 (2%)                    1 (2%)                                
      Cyst                                             1 (2%)                                                                       
      Hyperplasia                                                                1 (2%)                                             
      Hyperplasia, Histiocytic                                                                1 (2%)                                
   Spleen                                             (51)         (50)         (51)         (50)                                   
      Angiectasis                                                   1 (2%)       3 (6%)                                             
      Fibrosis                                         6 (12%)     12 (24%)      7 (14%)      7 (14%)                               
      Hematopoietic Cell Proliferation                 3 (6%)       5 (10%)     10 (20%)      6 (12%)                               
      Hyperplasia, Histiocytic                                                   1 (2%)                                             
      Necrosis, Focal                                  2 (4%)       1 (2%)       2 (4%)       1 (2%)                                
      Trabecula, Hyperplasia                                        1 (2%)                                                          
   Thymus                                             (46)         (46)         (48)         (49)                                   
      Angiectasis                                      1 (2%)                                                                       
      Cyst                                                          1 (2%)       2 (4%)       2 (4%)                                
      Ectopic Parathyroid Gland                                                  1 (2%)                                             
      Hyperplasia, Lymphoid                                         1 (2%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (48)         (48)         (49)         (49)                                   
      Dilatation                                      16 (33%)     22 (46%)     12 (24%)     14 (29%)                               
      Hemorrhage                                       1 (2%)                                                                       
      Hyperplasia                                      1 (2%)       2 (4%)       2 (4%)       1 (2%)                                
      Inflammation, Chronic                                                                   1 (2%)                                
      Metaplasia, Cartilagenous                                                  1 (2%)                                             
   Skin                                               (51)         (50)         (51)         (50)                                   
      Abscess                                          1 (2%)                                                                       
      Cyst Epithelial Inclusion                        1 (2%)       1 (2%)                                                          
      Hyperkeratosis                                                             1 (2%)                                             
      Inflammation, Chronic                            1 (2%)                    1 (2%)       1 (2%)                                
      Subcutaneous Tissue, Fat, Necrosis                                         1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (51)         (50)         (51)         (50)                                   
      Hyperostosis                                                  1 (2%)                    1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page   12                                                              
NTP Experiment-Test: 05089-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 12:36:25  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     0 ppm        50 ppm       100 ppm      200 ppm                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (51)         (50)         (51)         (50)                                   
      Atrophy                                                                                 1 (2%)                                
      Compression                                     11 (22%)     12 (24%)      4 (8%)       9 (18%)                               
      Hemorrhage                                       5 (10%)                                2 (4%)                                
      Hydrocephalus                                                                           1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (51)         (50)         (51)         (50)                                   
      Congestion                                       1 (2%)       2 (4%)       1 (2%)       1 (2%)                                
      Fibrosis, Focal                                  1 (2%)                                                                       
      Foreign Body                                                                            1 (2%)                                
      Hemorrhage                                       7 (14%)      1 (2%)       2 (4%)       3 (6%)                                
      Hyperplasia, Macrophage                          3 (6%)                                                                       
      Infiltration Cellular, Mixed Cell                3 (6%)                                 1 (2%)                                
      Inflammation, Acute                              1 (2%)                                                                       
      Inflammation, Suppurative                                                               1 (2%)                                
      Necrosis, Focal                                  1 (2%)                                                                       
      Alveolar Epithelium, Hyperplasia                 4 (8%)       2 (4%)       1 (2%)       3 (6%)                                
      Mediastinum, Hemorrhage                          1 (2%)                                                                       
      Mediastinum, Inflammation, Chronic               1 (2%)                                                                       
      Pleura, Inflammation, Chronic                    1 (2%)                                                                       
   Nose                                               (51)         (50)         (51)         (50)                                   
      Fungus                                           5 (10%)     11 (22%)      9 (18%)      8 (16%)                               
      Inflammation, Suppurative                       16 (31%)     13 (26%)     13 (25%)     11 (22%)                               
      Mucosa, Hyperplasia, Squamous                    1 (2%)                                                                       
   Trachea                                            (51)         (50)         (51)         (50)                                   
      Glands, Cyst                                     1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                (1)          (2)                                                              
      Pinna, Hyperplasia, Squamous                     1 (100%)                                                                     
   Eye                                                (5)          (3)          (1)          (2)                                    
      Atrophy                                          1 (20%)                                                                      
      Cataract                                         1 (20%)      2 (67%)                   2 (100%)                              
      Retina, Degeneration                             1 (20%)      3 (100%)     1 (100%)     2 (100%)                              
      Retrobulbar, Inflammation, Chronic               1 (20%)                                                                      
      Sclera, Metaplasia, Osseous                                                1 (100%)                                           
   Harderian Gland                                                              (1)                                                 
      Acinus, Dilatation                                                         1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page   13                                                              
NTP Experiment-Test: 05089-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 12:36:25  
____________________________________________________________________________________________________________________________________

         FISCHER 344 RATS MALE                     0 ppm        50 ppm       100 ppm      200 ppm                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (51)         (50)         (51)         (50)                                   
      Cyst                                             4 (8%)       5 (10%)      1 (2%)       2 (4%)                                
      Necrosis, Focal                                               1 (2%)                                                          
      Nephropathy                                     50 (98%)     50 (100%)    51 (100%)    50 (100%)                              
      Pigmentation                                                               1 (2%)       1 (2%)                                
      Pelvis, Dilatation                               2 (4%)                                                                       
      Pelvis, Transitional Epithelium, Hyperplasia     1 (2%)                                                                       
      Renal Tubule, Hyperplasia                        3 (6%)       3 (6%)       2 (4%)       1 (2%)                                
   Urethra                                            (1)                                                                           
      Bulbourethral Gland, Dilatation                  1 (100%)                                                                     
   Urinary Bladder                                    (51)         (50)         (51)         (50)                                   
      Edema                                                                                   1 (2%)                                
      Hemorrhage                                                                              1 (2%)                                
      Inflammation, Chronic                            1 (2%)                    1 (2%)                                             
      Muscularis, Hyperplasia                                                    1 (2%)                                             
      Transitional Epithelium, Hyperplasia             1 (2%)                                                                       
                                                                                                                                    

a  Number of animals examined microscopically at site and number of animals with lesion                                             

                                                             Page   14                                                              
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NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.