TR 392 Rat Pathology Tables
NTP Experiment-Test: 05089-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 12:36:25
Facility: Southern Research Institute
Chemical CAS #: 10599903
Lock Date: None
Cage Range: All
Reasons For Removal: 25019 Moribund Sacrifice 25020 Natural Death
25021 Terminal Sacrifice
Removal Date Range: All
Treatment Groups: Merge 001 001,002 0 ppm
Merge 002 003,004 0 ppm
Merge 003 013,014 50 ppm
Merge 004 015,016 50 ppm
Merge 005 009,010 100 ppm
Merge 006 011,012 100 ppm
Merge 007 005,006 200 ppm
Merge 008 007,008 200 ppm
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05089-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 12:36:25
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 ppm 50 ppm 100 ppm 200 ppm
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 70 70 70 70
Early Deaths
Moribund Sacrifice 16 17 20 23
Natural Death 3 5 1 3
Survivors
Terminal Sacrifice 31 28 29 24
Animals Examined Microscopically 50 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (50) (50) (50) (50)
Inflammation, Chronic 1 (2%)
Necrosis 1 (2%)
Parasite Metazoan 1 (2%) 2 (4%) 3 (6%)
Perforation 1 (2%)
Intestine Large, Rectum (50) (50) (50) (50)
Parasite Metazoan 4 (8%) 4 (8%) 3 (6%) 4 (8%)
Liver (50) (50) (50) (50)
Angiectasis 3 (6%) 2 (4%) 3 (6%) 2 (4%)
Basophilic Focus 1 (2%)
Congestion 3 (6%) 1 (2%) 1 (2%)
Cyst 1 (2%)
Fatty Change 10 (20%) 17 (34%) 13 (26%) 11 (22%)
Fibrosis, Focal 1 (2%)
Focal Cellular Change 36 (72%) 35 (70%) 32 (64%) 30 (60%)
Granuloma 39 (78%) 38 (76%) 36 (72%) 36 (72%)
Hematopoietic Cell Proliferation 6 (12%) 2 (4%) 3 (6%) 2 (4%)
Hemorrhage 1 (2%)
Hepatodiaphragmatic Nodule 10 (20%) 5 (10%) 6 (12%) 7 (14%)
Hyperplasia, Histiocytic, Lymphoid 1 (2%) 1 (2%) 2 (4%)
Hyperplasia, Multifocal 7 (14%) 6 (12%) 8 (16%) 15 (30%)
Infiltration Cellular, Mixed Cell 4 (8%) 11 (22%) 3 (6%) 9 (18%)
Inflammation, Focal 1 (2%)
Necrosis, Focal 1 (2%) 3 (6%) 1 (2%) 3 (6%)
Bile Duct, Hyperplasia 34 (68%) 32 (64%) 35 (70%) 35 (70%)
Biliary Tract, Fibrosis 28 (56%) 27 (54%) 26 (52%) 24 (48%)
Centrilobular, Atrophy 4 (8%) 7 (14%) 4 (8%) 9 (18%)
Centrilobular, Necrosis 1 (2%) 2 (4%)
Serosa, Fibrosis 1 (2%)
Mesentery (10) (11) (5) (9)
Accessory Spleen 1 (10%) 1 (9%)
Infiltration Cellular, Lymphocyte 1 (10%)
Inflammation, Chronic 5 (50%) 6 (55%) 3 (60%) 1 (11%)
Fat, Necrosis 2 (20%) 2 (18%) 1 (20%) 3 (33%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05089-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 12:36:25
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 ppm 50 ppm 100 ppm 200 ppm
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Pancreas (50) (50) (49) (50)
Atrophy, Focal 6 (12%) 6 (12%) 7 (14%) 4 (8%)
Cytoplasmic Alteration 1 (2%) 1 (2%)
Edema 1 (2%)
Duct, Dilatation 1 (2%)
Salivary Glands (49) (50) (50) (50)
Focal Cellular Change 1 (2%)
Inflammation, Chronic 1 (2%)
Mineralization 1 (2%)
Stomach, Forestomach (50) (50) (50) (49)
Cyst 1 (2%)
Edema 1 (2%)
Erosion 1 (2%)
Hyperplasia, Basal Cell 1 (2%)
Inflammation, Chronic 7 (14%) 3 (6%) 5 (10%) 5 (10%)
Perforation 2 (4%) 1 (2%) 1 (2%) 1 (2%)
Ulcer 6 (12%) 2 (4%) 3 (6%) 4 (8%)
Mucosa, Hyperplasia, Papillary 9 (18%) 2 (4%) 5 (10%) 6 (12%)
Stomach, Glandular (50) (50) (50) (50)
Edema 1 (2%)
Erosion 1 (2%) 1 (2%)
Inflammation, Chronic 2 (4%) 1 (2%) 2 (4%) 1 (2%)
Mucosa, Hyperplasia 1 (2%)
Tongue (1) (1) (1)
Hyperplasia, Squamous 1 (100%)
Tooth (1)
Dysplasia 1 (100%)
Inflammation, Suppurative 1 (100%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (1)
Mesenteric Artery, Inflammation, Chronic 1 (100%)
Heart (50) (50) (50) (50)
Thrombosis 2 (4%)
Artery, Inflammation, Chronic 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (50) (50) (50) (50)
Accessory Adrenal Cortical Nodule 1 (2%)
Angiectasis 2 (4%) 1 (2%)
Congestion 1 (2%) 2 (4%) 1 (2%)
Degeneration 1 (2%)
Fibrosis 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05089-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 12:36:25
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 ppm 50 ppm 100 ppm 200 ppm
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Focal Cellular Change 16 (32%) 14 (28%) 14 (28%) 16 (32%)
Hyperplasia 2 (4%)
Necrosis 1 (2%)
Vacuolization Cytoplasmic 1 (2%) 3 (6%) 2 (4%) 1 (2%)
Adrenal Gland, Medulla (50) (49) (50) (50)
Developmental Malformation 1 (2%)
Hyperplasia 5 (10%) 6 (12%) 6 (12%) 9 (18%)
Infiltration Cellular, Lymphocyte 1 (2%)
Parathyroid Gland (49) (47) (50) (50)
Hyperplasia 1 (2%)
Pituitary Gland (50) (49) (50) (50)
Angiectasis 38 (76%) 40 (82%) 36 (72%) 40 (80%)
Cyst 3 (6%) 1 (2%) 4 (8%) 3 (6%)
Hemorrhage 1 (2%) 1 (2%)
Pars Distalis, Hyperplasia, Focal 6 (12%) 6 (12%) 9 (18%) 2 (4%)
Thyroid Gland (50) (50) (50) (50)
Degeneration, Cystic 3 (6%)
Ultimobranchial Cyst 1 (2%)
C-Cell, Hyperplasia 7 (14%) 8 (16%) 11 (22%) 4 (8%)
Follicle, Cyst 1 (2%)
Follicular Cell, Hyperplasia 2 (4%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (1) (2)
Abdominal, Hemorrhage 1 (50%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (48) (50) (50) (49)
Degeneration, Cystic 1 (2%) 1 (2%) 2 (4%) 1 (2%)
Hyperplasia 3 (6%) 4 (8%) 6 (12%) 3 (6%)
Inflammation, Suppurative 11 (23%) 8 (16%) 9 (18%) 5 (10%)
Ovary (50) (50) (50) (50)
Angiectasis 1 (2%)
Corpus Luteum, Proliferation 1 (2%) 1 (2%)
Corpus Luteum, Thecal Cell, Hyperplasia 1 (2%) 1 (2%) 1 (2%)
Follicle, Cyst 2 (4%) 1 (2%) 2 (4%)
Periovarian Tissue, Cyst 1 (2%) 1 (2%) 2 (4%)
Uterus (50) (50) (50) (50)
Cyst 1 (2%)
Decidual Reaction 1 (2%)
Hemorrhage 2 (4%)
Hydrometra 2 (4%) 1 (2%) 5 (10%) 5 (10%)
Inflammation, Suppurative 2 (4%) 2 (4%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05089-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 12:36:25
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 ppm 50 ppm 100 ppm 200 ppm
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Cervix, Lamina Propria, Hyperplasia 1 (2%)
Endometrium, Hyperplasia, Cystic 26 (52%) 32 (64%) 38 (76%) 18 (36%)
Horn, Atrophy 1 (2%)
Vagina (8) (7) (11) (12)
Cyst 6 (75%) 6 (86%) 10 (91%) 7 (58%)
Inflammation, Suppurative 2 (25%) 4 (57%) 8 (73%) 2 (17%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (50) (50) (50)
Hypercellularity 4 (8%) 7 (14%) 5 (10%) 5 (10%)
Myelofibrosis 1 (2%) 1 (2%)
Lymph Node (50) (50) (50) (50)
Inguinal, Angiectasis 1 (2%)
Inguinal, Hyperplasia 3 (6%) 2 (4%)
Inguinal, Inflammation, Suppurative 1 (2%)
Mediastinal, Angiectasis 3 (6%) 3 (6%) 7 (14%) 7 (14%)
Mediastinal, Hyperplasia 1 (2%)
Pancreatic, Angiectasis 1 (2%) 3 (6%) 1 (2%)
Pancreatic, Hyperplasia, Histiocytic 1 (2%)
Renal, Angiectasis 2 (4%)
Lymph Node, Mandibular (48) (49) (49) (49)
Angiectasis 3 (6%) 1 (2%) 3 (6%) 2 (4%)
Hyperplasia 5 (10%) 1 (2%) 3 (6%) 1 (2%)
Hyperplasia, Lymphoid 1 (2%)
Lymph Node, Mesenteric (49) (50) (50) (50)
Angiectasis 2 (4%) 1 (2%) 3 (6%) 3 (6%)
Hyperplasia 1 (2%)
Hyperplasia, Lymphoid 1 (2%)
Spleen (50) (50) (50) (50)
Depletion Cellular 1 (2%) 2 (4%)
Developmental Malformation 1 (2%)
Fibrosis 1 (2%) 1 (2%) 1 (2%)
Hematopoietic Cell Proliferation 12 (24%) 8 (16%) 7 (14%) 9 (18%)
Hyperplasia, Histiocytic, Lymphoid 2 (4%) 4 (8%) 2 (4%) 6 (12%)
Necrosis, Focal 1 (2%)
Capsule, Hyperplasia, Histiocytic, Lymphoid 1 (2%)
Thymus (49) (47) (49) (49)
Cyst 3 (6%) 2 (4%)
Epithelial Cell, Hyperplasia 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05089-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 12:36:25
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 ppm 50 ppm 100 ppm 200 ppm
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (50) (50) (50) (50)
Dilatation 40 (80%) 43 (86%) 40 (80%) 38 (76%)
Fibrosis 1 (2%)
Hyperplasia 3 (6%) 3 (6%) 5 (10%) 7 (14%)
Inflammation, Suppurative 1 (2%)
Skin (50) (50) (50) (50)
Abscess 1 (2%)
Erosion 1 (2%)
Exudate 1 (2%)
Hemorrhage 1 (2%)
Hyperkeratosis 1 (2%)
Inflammation, Chronic 3 (6%) 1 (2%) 2 (4%) 1 (2%)
Ulcer 2 (4%) 1 (2%) 1 (2%)
Epidermis, Hyperplasia 1 (2%)
Sebaceous Gland, Cyst 1 (2%)
Subcutaneous Tissue, Foreign Body 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (50) (50) (50) (50)
Hyperostosis 9 (18%) 6 (12%) 11 (22%) 9 (18%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (48) (50) (49) (50)
Compression 11 (23%) 16 (32%) 5 (10%) 7 (14%)
Hemorrhage 2 (4%) 3 (6%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (50) (50) (50)
Congestion 3 (6%) 1 (2%) 1 (2%)
Foreign Body 1 (2%)
Hemorrhage 1 (2%) 3 (6%) 1 (2%) 2 (4%)
Hyperplasia, Macrophage 3 (6%) 1 (2%) 2 (4%) 3 (6%)
Infiltration Cellular, Mixed Cell 3 (6%) 4 (8%)
Inflammation, Acute 1 (2%)
Inflammation, Pyogranulomatous 1 (2%)
Alveolar Epithelium, Hyperplasia 2 (4%) 4 (8%) 4 (8%)
Nose (50) (50) (50) (50)
Foreign Body 1 (2%)
Fungus 3 (6%) 7 (14%) 3 (6%) 3 (6%)
Inflammation, Suppurative 3 (6%) 8 (16%) 3 (6%) 4 (8%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05089-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 12:36:25
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE 0 ppm 50 ppm 100 ppm 200 ppm
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (3) (1) (5) (6)
Atrophy 2 (33%)
Cataract 3 (100%) 4 (80%) 4 (67%)
Hemorrhage 1 (20%)
Cornea, Inflammation, Acute 1 (100%)
Retina, Degeneration 2 (67%) 3 (60%) 6 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50) (50)
Atrophy 1 (2%) 1 (2%)
Cyst 3 (6%)
Fibrosis 1 (2%)
Hydronephrosis 1 (2%)
Inflammation, Suppurative 1 (2%) 1 (2%) 1 (2%)
Mineralization 2 (4%) 2 (4%) 2 (4%)
Nephropathy 46 (92%) 48 (96%) 50 (100%) 49 (98%)
Pigmentation 1 (2%) 1 (2%)
Pelvis, Transitional Epithelium, Hyperplasia 1 (2%) 1 (2%)
Renal Tubule, Vacuolization Cytoplasmic 1 (2%)
Urinary Bladder (50) (50) (50) (50)
Hemorrhage 1 (2%)
Inflammation, Chronic 1 (2%)
Transitional Epithelium, Hyperplasia 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05089-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 12:36:25
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 ppm 50 ppm 100 ppm 200 ppm
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 70 70 70 70
Early Deaths
Moribund Sacrifice 34 27 34 33
Natural Death 3 1 3 1
Survivors
Terminal Sacrifice 14 22 14 16
Animals Examined Microscopically 51 50 51 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Cecum (51) (50) (50) (50)
Edema 1 (2%)
Hemorrhage 1 (2%)
Inflammation, Chronic 1 (2%)
Parasite Metazoan 1 (2%) 1 (2%)
Intestine Large, Colon (51) (50) (51) (49)
Parasite Metazoan 1 (2%) 3 (6%) 2 (4%) 1 (2%)
Intestine Large, Rectum (51) (50) (50) (49)
Parasite Metazoan 5 (10%) 4 (8%) 1 (2%) 3 (6%)
Intestine Small, Ileum (51) (50) (51) (49)
Cyst 1 (2%)
Intestine Small, Jejunum (51) (50) (51) (49)
Metaplasia, Osseous 1 (2%)
Liver (51) (50) (51) (50)
Angiectasis 8 (16%) 3 (6%) 6 (12%) 2 (4%)
Atrophy, Focal 1 (2%)
Basophilic Focus 1 (2%) 1 (2%)
Congestion 1 (2%) 2 (4%) 1 (2%)
Degeneration, Cystic 10 (20%) 14 (28%) 10 (20%) 5 (10%)
Eosinophilic Focus 1 (2%) 2 (4%)
Fatty Change 14 (27%) 21 (42%) 17 (33%) 14 (28%)
Focal Cellular Change 11 (22%) 12 (24%) 13 (25%) 13 (26%)
Hemorrhage 3 (6%) 1 (2%)
Hepatodiaphragmatic Nodule 5 (10%) 4 (8%) 3 (6%) 4 (8%)
Hyperplasia 2 (4%)
Hyperplasia, Multifocal 15 (29%) 19 (38%) 22 (43%) 12 (24%)
Infiltration Cellular, Mixed Cell 7 (14%) 4 (8%) 10 (20%) 12 (24%)
Inflammation, Focal 18 (35%) 24 (48%) 20 (39%) 18 (36%)
Mineralization 1 (2%)
Mixed Cell Focus 2 (4%) 1 (2%)
Necrosis, Focal 2 (4%) 2 (4%) 3 (6%) 1 (2%)
Thrombosis 1 (2%) 2 (4%) 2 (4%)
Bile Duct, Dilatation 1 (2%)
Bile Duct, Hyperplasia 48 (94%) 50 (100%) 49 (96%) 49 (98%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 05089-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 12:36:25
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 ppm 50 ppm 100 ppm 200 ppm
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Biliary Tract, Fibrosis 42 (82%) 48 (96%) 47 (92%) 44 (88%)
Centrilobular, Atrophy 14 (27%) 15 (30%) 15 (29%) 13 (26%)
Mesentery (31) (15) (15) (24)
Hemorrhage 1 (3%) 1 (7%) 1 (7%)
Inflammation, Chronic 7 (23%) 4 (27%) 3 (20%) 3 (13%)
Fat, Necrosis 11 (35%) 3 (20%) 6 (40%) 12 (50%)
Pancreas (51) (50) (51) (50)
Accessory Spleen 2 (4%)
Atrophy, Diffuse 1 (2%)
Atrophy, Focal 13 (25%) 18 (36%) 14 (27%) 16 (32%)
Cytoplasmic Alteration 1 (2%) 1 (2%) 1 (2%)
Edema 1 (2%)
Inflammation, Chronic 1 (2%)
Acinar Cell, Hyperplasia 3 (6%) 1 (2%)
Duct, Dilatation 3 (6%) 1 (2%)
Salivary Glands (51) (50) (51) (50)
Infiltration Cellular, Lipocyte 1 (2%)
Stomach, Forestomach (51) (50) (51) (49)
Hyperplasia, Squamous 1 (2%) 1 (2%)
Inflammation, Chronic 7 (14%) 7 (14%) 4 (8%) 5 (10%)
Mineralization 1 (2%) 1 (2%)
Perforation 1 (2%) 1 (2%)
Ulcer 6 (12%) 4 (8%) 2 (4%) 1 (2%)
Mucosa, Hyperplasia, Papillary 6 (12%) 6 (12%) 7 (14%) 6 (12%)
Stomach, Glandular (51) (50) (51) (49)
Edema 1 (2%) 1 (2%)
Erosion 3 (6%) 2 (4%) 2 (4%)
Inflammation, Chronic 8 (16%) 2 (4%) 3 (6%) 2 (4%)
Mineralization 1 (2%) 3 (6%) 1 (2%)
Pigmentation, Focal 2 (4%)
Ulcer 1 (2%) 1 (2%)
Epithelium, Degeneration, Hyaline 1 (2%)
Mucosa, Cyst 1 (2%)
Mucosa, Hyperplasia 1 (2%)
Tooth (2) (1)
Epithelium Alveolus, Cyst 1 (50%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (5) (4) (2)
Aorta, Mineralization 1 (20%)
Mesenteric Artery, Hypertrophy 1 (25%)
Mesenteric Artery, Inflammation, Chronic 4 (80%) 4 (100%) 2 (100%)
Mesenteric Artery, Mineralization 1 (20%) 1 (25%)
Heart (51) (50) (51) (50)
Mineralization 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 05089-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 12:36:25
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 ppm 50 ppm 100 ppm 200 ppm
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - CONT
Thrombosis 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (51) (50) (51) (50)
Angiectasis 1 (2%)
Cyst 1 (2%)
Focal Cellular Change 13 (25%) 22 (44%) 11 (22%) 10 (20%)
Hematopoietic Cell Proliferation 1 (2%)
Hemorrhage 1 (2%)
Mineralization 2 (4%)
Necrosis 1 (2%) 1 (2%) 1 (2%)
Vacuolization Cytoplasmic 2 (4%) 2 (4%)
Adrenal Gland, Medulla (51) (50) (51) (50)
Cyst 1 (2%)
Hemorrhage 1 (2%)
Hyperplasia 10 (20%) 12 (24%) 9 (18%) 11 (22%)
Necrosis 1 (2%)
Islets, Pancreatic (51) (50) (51) (50)
Hyperplasia 1 (2%)
Parathyroid Gland (50) (48) (49) (50)
Hyperplasia 4 (8%) 4 (8%) 1 (2%)
Pituitary Gland (50) (50) (51) (50)
Angiectasis 17 (34%) 23 (46%) 18 (35%) 21 (42%)
Atrophy 1 (2%)
Cyst 2 (4%) 4 (8%) 3 (6%) 1 (2%)
Hemorrhage 3 (6%)
Pigmentation 1 (2%)
Pars Distalis, Focal Cellular Change 1 (2%)
Pars Distalis, Hyperplasia 1 (2%)
Pars Distalis, Hyperplasia, Focal 8 (16%) 4 (8%) 7 (14%) 7 (14%)
Pars Nervosa, Focal Cellular Change 1 (2%)
Thyroid Gland (51) (50) (51) (50)
Degeneration, Cystic 6 (12%) 8 (16%) 4 (8%) 7 (14%)
Pigmentation 1 (2%)
Ultimobranchial Cyst 1 (2%)
C-Cell, Hyperplasia 5 (10%) 4 (8%) 2 (4%) 5 (10%)
Follicle, Cyst 1 (2%) 2 (4%)
Follicular Cell, Hyperplasia 1 (2%) 2 (4%) 2 (4%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 05089-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 12:36:25
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 ppm 50 ppm 100 ppm 200 ppm
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (51) (50) (51) (50)
Edema 1 (2%)
Inflammation, Chronic 1 (2%) 1 (2%)
Preputial Gland (50) (50) (51) (50)
Degeneration, Cystic 3 (6%) 1 (2%)
Fibrosis 1 (2%)
Hyperplasia 2 (4%) 1 (2%) 1 (2%)
Inflammation, Suppurative 20 (40%) 23 (46%) 22 (43%) 23 (46%)
Prostate (51) (50) (51) (50)
Degeneration, Cystic 1 (2%)
Edema 1 (2%)
Hyperplasia, Focal 5 (10%) 1 (2%)
Inflammation, Suppurative 28 (55%) 42 (84%) 31 (61%) 35 (70%)
Seminal Vesicle (51) (50) (51) (50)
Dilatation 2 (4%)
Inflammation, Chronic 1 (2%) 1 (2%)
Testes (51) (50) (51) (50)
Fibrosis 1 (2%)
Hyperplasia 1 (2%)
Artery, Inflammation, Chronic 1 (2%) 1 (2%)
Germinal Epithelium, Degeneration 15 (29%) 14 (28%) 14 (27%) 11 (22%)
Interstitial Cell, Hyperplasia 13 (25%) 9 (18%) 11 (22%) 9 (18%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (51) (50) (51) (50)
Hypercellularity 2 (4%)
Myelofibrosis 4 (8%) 2 (4%) 3 (6%) 1 (2%)
Lymph Node (51) (50) (51) (50)
Bronchial, Hyperplasia 1 (2%)
Iliac, Hyperplasia 1 (2%)
Inguinal, Hyperplasia 1 (2%) 1 (2%)
Mediastinal, Angiectasis 6 (12%) 3 (6%) 1 (2%) 1 (2%)
Mediastinal, Hyperplasia 1 (2%) 2 (4%) 1 (2%)
Mediastinal, Hyperplasia, Lymphoid 1 (2%)
Pancreatic, Angiectasis 1 (2%)
Pancreatic, Hyperplasia 2 (4%)
Pancreatic, Hyperplasia, Histiocytic 1 (2%)
Renal, Angiectasis 1 (2%) 1 (2%)
Renal, Hyperplasia 1 (2%)
Lymph Node, Mandibular (51) (50) (51) (49)
Angiectasis 3 (6%) 1 (2%) 2 (4%)
Cyst 1 (2%)
Hemorrhage 1 (2%)
Hyperplasia 4 (8%) 4 (8%) 9 (18%) 3 (6%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 05089-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 12:36:25
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 ppm 50 ppm 100 ppm 200 ppm
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Hyperplasia, Lymphoid 1 (2%)
Lymph Node, Mesenteric (51) (49) (51) (50)
Angiectasis 1 (2%) 1 (2%) 1 (2%)
Cyst 1 (2%)
Hyperplasia 1 (2%)
Hyperplasia, Histiocytic 1 (2%)
Spleen (51) (50) (51) (50)
Angiectasis 1 (2%) 3 (6%)
Fibrosis 6 (12%) 12 (24%) 7 (14%) 7 (14%)
Hematopoietic Cell Proliferation 3 (6%) 5 (10%) 10 (20%) 6 (12%)
Hyperplasia, Histiocytic 1 (2%)
Necrosis, Focal 2 (4%) 1 (2%) 2 (4%) 1 (2%)
Trabecula, Hyperplasia 1 (2%)
Thymus (46) (46) (48) (49)
Angiectasis 1 (2%)
Cyst 1 (2%) 2 (4%) 2 (4%)
Ectopic Parathyroid Gland 1 (2%)
Hyperplasia, Lymphoid 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (48) (48) (49) (49)
Dilatation 16 (33%) 22 (46%) 12 (24%) 14 (29%)
Hemorrhage 1 (2%)
Hyperplasia 1 (2%) 2 (4%) 2 (4%) 1 (2%)
Inflammation, Chronic 1 (2%)
Metaplasia, Cartilagenous 1 (2%)
Skin (51) (50) (51) (50)
Abscess 1 (2%)
Cyst Epithelial Inclusion 1 (2%) 1 (2%)
Hyperkeratosis 1 (2%)
Inflammation, Chronic 1 (2%) 1 (2%) 1 (2%)
Subcutaneous Tissue, Fat, Necrosis 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (51) (50) (51) (50)
Hyperostosis 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 12
NTP Experiment-Test: 05089-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 12:36:25
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 ppm 50 ppm 100 ppm 200 ppm
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (51) (50) (51) (50)
Atrophy 1 (2%)
Compression 11 (22%) 12 (24%) 4 (8%) 9 (18%)
Hemorrhage 5 (10%) 2 (4%)
Hydrocephalus 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (51) (50) (51) (50)
Congestion 1 (2%) 2 (4%) 1 (2%) 1 (2%)
Fibrosis, Focal 1 (2%)
Foreign Body 1 (2%)
Hemorrhage 7 (14%) 1 (2%) 2 (4%) 3 (6%)
Hyperplasia, Macrophage 3 (6%)
Infiltration Cellular, Mixed Cell 3 (6%) 1 (2%)
Inflammation, Acute 1 (2%)
Inflammation, Suppurative 1 (2%)
Necrosis, Focal 1 (2%)
Alveolar Epithelium, Hyperplasia 4 (8%) 2 (4%) 1 (2%) 3 (6%)
Mediastinum, Hemorrhage 1 (2%)
Mediastinum, Inflammation, Chronic 1 (2%)
Pleura, Inflammation, Chronic 1 (2%)
Nose (51) (50) (51) (50)
Fungus 5 (10%) 11 (22%) 9 (18%) 8 (16%)
Inflammation, Suppurative 16 (31%) 13 (26%) 13 (25%) 11 (22%)
Mucosa, Hyperplasia, Squamous 1 (2%)
Trachea (51) (50) (51) (50)
Glands, Cyst 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Ear (1) (2)
Pinna, Hyperplasia, Squamous 1 (100%)
Eye (5) (3) (1) (2)
Atrophy 1 (20%)
Cataract 1 (20%) 2 (67%) 2 (100%)
Retina, Degeneration 1 (20%) 3 (100%) 1 (100%) 2 (100%)
Retrobulbar, Inflammation, Chronic 1 (20%)
Sclera, Metaplasia, Osseous 1 (100%)
Harderian Gland (1)
Acinus, Dilatation 1 (100%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 13
NTP Experiment-Test: 05089-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC CHLORAMINE Date: 05/06/97
Route: DOSED WATER Time: 12:36:25
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE 0 ppm 50 ppm 100 ppm 200 ppm
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (51) (50) (51) (50)
Cyst 4 (8%) 5 (10%) 1 (2%) 2 (4%)
Necrosis, Focal 1 (2%)
Nephropathy 50 (98%) 50 (100%) 51 (100%) 50 (100%)
Pigmentation 1 (2%) 1 (2%)
Pelvis, Dilatation 2 (4%)
Pelvis, Transitional Epithelium, Hyperplasia 1 (2%)
Renal Tubule, Hyperplasia 3 (6%) 3 (6%) 2 (4%) 1 (2%)
Urethra (1)
Bulbourethral Gland, Dilatation 1 (100%)
Urinary Bladder (51) (50) (51) (50)
Edema 1 (2%)
Hemorrhage 1 (2%)
Inflammation, Chronic 1 (2%) 1 (2%)
Muscularis, Hyperplasia 1 (2%)
Transitional Epithelium, Hyperplasia 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 14
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