National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/1196

TR 392 Rat Pathology Tables

NTP Experiment-Test: 05089-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97
Route: DOSED WATER                                                                                                Time: 16:21:47




       Facility:  Southern Research Institute

       Chemical CAS #:  10599903

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All






































                                                              Page   1

NTP Experiment-Test: 05089-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 16:21:47  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 6| 6| 7| 7| 7| 5| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 0| 1| 3| 3| 3| 2| 6| 0| 3| 3| 3| 6| 3| 3| 3| 7| 7| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 8| 2| 1| 1| 1| 0| 8| 3| 1| 1| 1| 8| 1| 1| 1| 3| 5| 0| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    VEHICLE                                | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                1  2  2   |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     |                            X                                             |             
      Congestion                           |                            2                                             |             
      Fatty Change                         | 1  1           2  3  3              2                                    |             
      Fibrosis, Focal                      |                                                                          |             
      Focal Cellular Change                | 2  2  2  1  1           2        1  1  1  2  2     2  1  2     2  1  2  2|             
      Granuloma                            |       2  1  1  1  2     2  1  2  2  1  1  2  2     2  1  1  2  1  1  2  1|             
      Hematopoietic Cell Proliferation     | 1  1           1                                                        1|             
      Hemorrhage                           |                                                                          |             
      Hepatodiaphragmatic Nodule           | 2                    3                                   3           2  3|             
      Hyperplasia, Histiocytic, Lymphoid   |                                                                          |             
      Hyperplasia, Multifocal              |                      2                                                   |             
      Infiltration Cellular, Mixed Cell    | 2              2  2                                                      |             
      Necrosis, Focal                      |                1                                                         |             
      Bile Duct, Hyperplasia               |          1  1        2  2        1  1  1  1  1        1  1  1  1  2  2   |             
      Biliary Tract, Fibrosis              |          1  1        2  2        1  1  1  1  1        1  1  1  1  2  2   |             
      Centrilobular, Atrophy               | 2                    2                                                   |             
                                            __________________________________________________________________________|             
   Mesentery                               | +              +              +           +                    +         |             
      Accessory Spleen                     |                                                                          |             
      Infiltration Cellular, Lymphocyte    |                                           2                              |             
      Inflammation, Chronic                | 2              3              2                                          |             
      Fat, Necrosis                        |                                                                3         |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy, Focal                       |                                           1                       1      |             
      Cytoplasmic Alteration               |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Focal Cellular Change                |          1                                                               |             
      Inflammation, Chronic                |    4                                                                     |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                          |             
      Inflammation, Chronic                | 3              3     2                                                   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05089-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 16:21:47  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 6| 6| 7| 7| 7| 5| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 0| 1| 3| 3| 3| 2| 6| 0| 3| 3| 3| 6| 3| 3| 3| 7| 7| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 8| 2| 1| 1| 1| 0| 8| 3| 1| 1| 1| 8| 1| 1| 1| 3| 5| 0| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    VEHICLE                                | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Perforation                          |                4                                                         |             
      Ulcer                                | 3              4     2                                                   |             
      Mucosa, Hyperplasia, Papillary       | 2              3     2                                2                  |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                          |             
      Inflammation, Chronic                |                2                                                         |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Dysplasia                            |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Artery, Inflammation, Chronic        |                                           3                              |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                                  1                                       |             
      Congestion                           |                                                                          |             
      Focal Cellular Change                | 1        2     1     2  1  2           1     1  1                        |             
      Vacuolization Cytoplasmic            |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                         2              1                    1            |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 2  2  2  2  2  3  3  2  2  3  3  3  3  3     2  2  2              1      |             
      Cyst                                 |                                                                2     2   |             
      Pars Distalis, Focal Cellular Change |                                                                          |             
      Pars Distalis, Hyperplasia, Focal    | 1                    2                                                  2|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 |                      1                 1                       1         |             
      Ultimobranchial Cyst                 |                                  1                                       |             
      C-Cell, Hyperplasia                  |                      1                             1                    2|             
      Follicle, Cyst                       |                               2                                          |             
      Follicular Cell, Hyperplasia         |                                  1     1                                 |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                            +                                             |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05089-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 16:21:47  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 6| 6| 7| 7| 7| 5| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 0| 1| 3| 3| 3| 2| 6| 0| 3| 3| 3| 6| 3| 3| 3| 7| 7| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 8| 2| 1| 1| 1| 0| 8| 3| 1| 1| 1| 8| 1| 1| 1| 3| 5| 0| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    VEHICLE                                | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Hyperplasia                          |                3                                                         |             
      Inflammation, Suppurative            |                2     3  3                          4                     |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Corpus Luteum, Proliferation         |                                                                          |             
      Corpus Luteum, Thecal Cell,          |                                                                          |             
          Hyperplasia                      |                                                                          |             
      Follicle, Cyst                       |                               1                                          |             
      Periovarian Tissue, Cyst             |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                 4                    3   |             
      Hydrometra                           |                                                                1         |             
      Inflammation, Suppurative            |                                                                          |             
      Endometrium, Hyperplasia, Cystic     | 1        1  2  1  2  1  1  1  1  1  1  1  1  1  1  1  1  1  1  2         |             
                                            __________________________________________________________________________|             
   Vagina                                  |             +                             +  +                           |             
      Cyst                                 |             3                             2                              |             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hypercellularity                     | 2                          1                       2                     |             
      Myelofibrosis                        | 2                                                                        |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mediastinal, Angiectasis             | 2                                         2        3                     |             
      Pancreatic, Angiectasis              | 2                                                                        |             
      Renal, Angiectasis                   |                                                                          |             
      Renal, Hyperplasia                   |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                               2                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Hyperplasia                          | 2  2           1           3                                             |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 3                                                                        |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     | 3           1  3  3                          4     2                    3|             
      Hyperplasia, Histiocytic, Lymphoid   |                                        2                                 |             
      Capsule, Hyperplasia, Histiocytic,   |                                                                          |             
           Lymphoid                        |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           | 2  2  2  2  2  3  2     3  2  2     2  2  2  2  2  2  3  2  3     1  2  2|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05089-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 16:21:47  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 6| 6| 7| 7| 7| 5| 6| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 0| 1| 3| 3| 3| 2| 6| 0| 3| 3| 3| 6| 3| 3| 3| 7| 7| 3| 3| 3| 3| 3| 3| 3| 3|             
                                           | 8| 2| 1| 1| 1| 0| 8| 3| 1| 1| 1| 8| 1| 1| 1| 3| 5| 0| 1| 1| 1| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    VEHICLE                                | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Abscess                              |                                                          3               |             
      Inflammation, Chronic                |                      1                                                   |             
      Ulcer                                |                      1                                                   |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperostosis                         |                3                 3        2        1                    3|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Compression                          |       1        4  3           3  3                                2      |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Foreign Body                         |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Macrophage              |                                                                   2  1   |             
      Infiltration Cellular, Mixed Cell    |                                                                          |             
      Inflammation, Pyogranulomatous       |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                                                   2  1   |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                                                          |             
      Fungus                               |                2                                                         |             
      Inflammation, Suppurative            |                2                                                         |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                            +                                             |             
                                            __________________________________________________________________________|             
   Eye                                     |             +                                   +        +               |             
      Cataract                             |             3                                   3        3               |             
      Retina, Degeneration                 |             4                                            3               |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |    +                                                                     |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                                                          |             
      Nephropathy                          | 4  1  2  2  2  3  3  1  2  3  2  2  3  2  3  2     2  3  3  2  2  2  2  3|             
      Renal Tubule, Vacuolization          |                                                                          |             
          Cytoplasmic                      |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05089-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 16:21:47  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 5| 6| 7| 7| 7| 4| 5| 6| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 5| 5| 5| 5| 5| 6| 5| 0| 3| 3| 7| 7| 6| 3| 3| 2| 3| 3| 3| 3| 6| 3| 3| 3| 3|             
                                           | 7| 7| 8| 8| 9| 9| 0| 2| 1| 1| 2| 8| 7| 1| 9| 1| 1| 1| 1| 1| 6| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    VEHICLE                                | 6| 6| 6| 6| 6| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                  1                                       |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                        3                          3     2|             
      Basophilic Focus                     |                                                                          |             
      Congestion                           |                2                                      2                  |             
      Fatty Change                         |                3           3  4                                2         |             
      Fibrosis, Focal                      |                            3                                             |             
      Focal Cellular Change                | 1           1  1     2  1           2  2  2  1  2  2  2  1     2  2     2|             
      Granuloma                            | 1  2     1  2  1     3  1           1  2  2  1  2     2  1  2  2     1  2|             
      Hematopoietic Cell Proliferation     |                                  2           2                           |             
      Hemorrhage                           |                                                                   3      |             
      Hepatodiaphragmatic Nodule           |                               2  2                 2                 2  2|             
      Hyperplasia, Histiocytic, Lymphoid   |                            3                                             |             
      Hyperplasia, Multifocal              |                   2              2  1     1  1                    2      |             
      Infiltration Cellular, Mixed Cell    |                                                                2         |             
      Necrosis, Focal                      |                                                                          |             
      Bile Duct, Hyperplasia               | 1  1  1  1        2  1  1  2  1  1  1     1     1  1  1     1  1  1  1  1|             
      Biliary Tract, Fibrosis              |                   1  1  1  2  1  1  1              1  1        1  1  1   |             
      Centrilobular, Atrophy               |                               2                                   4      |             
                                            __________________________________________________________________________|             
   Mesentery                               |                +              +              +                    +      |             
      Accessory Spleen                     |                               X                                          |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Inflammation, Chronic                |                2                             3                           |             
      Fat, Necrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy, Focal                       |          2  1           1  1                                         1   |             
      Cytoplasmic Alteration               |                                                                      1   |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Focal Cellular Change                |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                            1                                             |             
      Inflammation, Chronic                |                   3        2  3              3                           |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   6                                                               
NTP Experiment-Test: 05089-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 16:21:47  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 5| 6| 7| 7| 7| 4| 5| 6| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 5| 5| 5| 5| 5| 6| 5| 0| 3| 3| 7| 7| 6| 3| 3| 2| 3| 3| 3| 3| 6| 3| 3| 3| 3|             
                                           | 7| 7| 8| 8| 9| 9| 0| 2| 1| 1| 2| 8| 7| 1| 9| 1| 1| 1| 1| 1| 6| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    VEHICLE                                | 6| 6| 6| 6| 6| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Perforation                          |                                              3                           |             
      Ulcer                                |                   2           3              4                           |             
      Mucosa, Hyperplasia, Papillary       |                   3        1  2              3     1                     |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                               2                                          |             
      Inflammation, Chronic                |                               2                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                        +                                 |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                           +                              |             
      Dysplasia                            |                                           4                              |             
      Inflammation, Suppurative            |                                           4                              |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Artery, Inflammation, Chronic        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                                                                          |             
      Congestion                           |                                                                   3      |             
      Focal Cellular Change                |       1     1     1     1              4     1                 1  1      |             
      Vacuolization Cytoplasmic            |                               3                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                        2                                 |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 2  1  2  3     2     2  2  2     2     3  3  2     3  4  3  2  4  3  3  2|             
      Cyst                                 |                   2                                                      |             
      Pars Distalis, Focal Cellular Change |                                                                          |             
      Pars Distalis, Hyperplasia, Focal    | 2                       2           2                                    |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 |                                                                          |             
      Ultimobranchial Cyst                 |                                                                          |             
      C-Cell, Hyperplasia                  | 1  1  1  1  1     1                          1              1            |             
      Follicle, Cyst                       |                                                                          |             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   7                                                               
NTP Experiment-Test: 05089-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 16:21:47  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 5| 6| 7| 7| 7| 4| 5| 6| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 5| 5| 5| 5| 5| 6| 5| 0| 3| 3| 7| 7| 6| 3| 3| 2| 3| 3| 3| 3| 6| 3| 3| 3| 3|             
                                           | 7| 7| 8| 8| 9| 9| 0| 2| 1| 1| 2| 8| 7| 1| 9| 1| 1| 1| 1| 1| 6| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    VEHICLE                                | 6| 6| 6| 6| 6| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Hyperplasia                          |                                              2                       3   |             
      Inflammation, Suppurative            |                                              3  2  1     3  2     2  3   |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Corpus Luteum, Proliferation         |                                                                          |             
      Corpus Luteum, Thecal Cell,          |                                                                          |             
          Hyperplasia                      |                                                                          |             
      Follicle, Cyst                       |                   1                                                      |             
      Periovarian Tissue, Cyst             |          3                                                               |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Hydrometra                           |                                              2                           |             
      Inflammation, Suppurative            |                                                                          |             
      Endometrium, Hyperplasia, Cystic     |                      2  2     2                                1         |             
                                            __________________________________________________________________________|             
   Vagina                                  |    +                          +        +     +  +     +                  |             
      Cyst                                 |    3                                   X     3  2     4                  |             
      Inflammation, Suppurative            |    3                                         3        4                  |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hypercellularity                     |                                  3                                       |             
      Myelofibrosis                        |    1     1                                                               |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mediastinal, Angiectasis             | 1     1  1  1                                                            |             
      Pancreatic, Angiectasis              |                                                                          |             
      Renal, Angiectasis                   |                                                                          |             
      Renal, Hyperplasia                   |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                1                                                     2   |             
      Hyperplasia, Lymphoid                |                      2                                                   |             
      Hyperplasia                          |                                           3                              |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                           2                              |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                           3  4                          2|             
      Hyperplasia, Histiocytic, Lymphoid   |                                                                          |             
      Capsule, Hyperplasia, Histiocytic,   |                                                                          |             
           Lymphoid                        |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                1           2  2        1  2  2  2  2  2  2  2  2  2  3  2|             
      Hyperplasia                          |                                              2        2  3               |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   8                                                               
NTP Experiment-Test: 05089-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 16:21:47  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 5| 6| 7| 7| 7| 4| 5| 6| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 5| 5| 5| 5| 5| 6| 5| 0| 3| 3| 7| 7| 6| 3| 3| 2| 3| 3| 3| 3| 6| 3| 3| 3| 3|             
                                           | 7| 7| 8| 8| 9| 9| 0| 2| 1| 1| 2| 8| 7| 1| 9| 1| 1| 1| 1| 1| 6| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    VEHICLE                                | 6| 6| 6| 6| 6| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Abscess                              |                                                                          |             
      Inflammation, Chronic                |                            2           2                                 |             
      Ulcer                                |                                        2                                 |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperostosis                         | 2                                            3        2  3               |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Compression                          |                            3                 2        3     3            |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |       1                                                                  |             
      Foreign Body                         |                3                                                         |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Macrophage              |                            2                                             |             
      Infiltration Cellular, Mixed Cell    |                                              2                          2|             
      Inflammation, Pyogranulomatous       |                3                                                         |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                4                                                         |             
      Fungus                               |                3  2                                                      |             
      Inflammation, Suppurative            |                4  2                                                      |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Cataract                             |                                                                          |             
      Retina, Degeneration                 |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +  +  +  +                                                               |             
      Hyperplasia, Lymphoid                | 2  2  2  2                                                               |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |    1  2  1  2                 1  1                                       |             
      Nephropathy                          | 1  1        1  1  1  1  2  2        1  2  2  3  2     3  3  1  2  2  2  3|             
      Renal Tubule, Vacuolization          |                                                                          |             
          Cytoplasmic                      |                               2                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   9                                                               
NTP Experiment-Test: 05089-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 16:21:47  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 6| 3| 3| 3| 3| 5| 5| 5| 5| 5|                                            |            |
                                           | 6| 1| 1| 1| 1| 7| 8| 8| 9| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                            |      A     |
    VEHICLE                                | 2| 2| 2| 2| 2| 4| 4| 4| 4| 4|                                            |      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Parasite Metazoan                    |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Parasite Metazoan                    |             2                                                            |      4  1.8|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Angiectasis                          |                                                                          |      3  2.7|
      Basophilic Focus                     |                                                                          |      1     |
      Congestion                           |                                                                          |      3  2.0|
      Fatty Change                         |                                                                          |     10  2.4|
      Fibrosis, Focal                      |                                                                          |      1  3.0|
      Focal Cellular Change                |    1  2  1  2  1  1  1  1  1                                             |     43  1.5|
      Granuloma                            | 1     2  2  2  1  2  1                                                   |     46  1.5|
      Hematopoietic Cell Proliferation     |                                                                          |      6  1.3|
      Hemorrhage                           |                                                                          |      1  3.0|
      Hepatodiaphragmatic Nodule           |                                                                          |     10  2.3|
      Hyperplasia, Histiocytic, Lymphoid   |                                                                          |      1  3.0|
      Hyperplasia, Multifocal              |                                                                          |      7  1.6|
      Infiltration Cellular, Mixed Cell    |                                                                          |      4  2.0|
      Necrosis, Focal                      |                                                                          |      1  1.0|
      Bile Duct, Hyperplasia               |    2     2  1  1     1  1                                                |     41  1.2|
      Biliary Tract, Fibrosis              |    2                                                                     |     28  1.2|
      Centrilobular, Atrophy               |                                                                          |      4  2.5|
                                            __________________________________________________________________________|____________|
   Mesentery                               |          +                                                               |  10        |
      Accessory Spleen                     |                                                                          |      1     |
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                                                          |      5  2.4|
      Fat, Necrosis                        |          2                                                               |      2  2.5|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Atrophy, Focal                       |          1                                                               |      8  1.1|
      Cytoplasmic Alteration               |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Focal Cellular Change                |                                                                          |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  10                                                               
NTP Experiment-Test: 05089-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 16:21:47  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 6| 3| 3| 3| 3| 5| 5| 5| 5| 5|                                            |            |
                                           | 6| 1| 1| 1| 1| 7| 8| 8| 9| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                            |      A     |
    VEHICLE                                | 2| 2| 2| 2| 2| 4| 4| 4| 4| 4|                                            |      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Chronic                |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Erosion                              |                                                                          |      1  1.0|
      Inflammation, Chronic                |                                                                          |      7  2.7|
      Perforation                          |                                                                          |      2  3.5|
      Ulcer                                |                                                                          |      6  3.0|
      Mucosa, Hyperplasia, Papillary       |                                                                          |      9  2.1|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Erosion                              |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
      Dysplasia                            |                                                                          |      1  4.0|
      Inflammation, Suppurative            |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Artery, Inflammation, Chronic        |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Accessory Adrenal Cortical Nodule    |                                                                          |      1  1.0|
      Congestion                           |                                                                          |      1  3.0|
      Focal Cellular Change                |    1           1                                                         |     19  1.3|
      Vacuolization Cytoplasmic            |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperplasia                          |          1                                                               |      5  1.4|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Angiectasis                          | 3  2     3  2  2  1  1     1                                             |     46  2.3|
      Cyst                                 |                                                                          |      3  2.0|
      Pars Distalis, Focal Cellular Change |                   1                                                      |      1  1.0|
      Pars Distalis, Hyperplasia, Focal    |    1                                                                     |      7  1.7|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Degeneration, Cystic                 |                                                                          |      3  1.0|
      Ultimobranchial Cyst                 |                                                                          |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  11                                                               
NTP Experiment-Test: 05089-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 16:21:47  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 6| 3| 3| 3| 3| 5| 5| 5| 5| 5|                                            |            |
                                           | 6| 1| 1| 1| 1| 7| 8| 8| 9| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                            |      A     |
    VEHICLE                                | 2| 2| 2| 2| 2| 4| 4| 4| 4| 4|                                            |      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      C-Cell, Hyperplasia                  |    2           1  1  1  1  1                                             |     17  1.1|
      Follicle, Cyst                       |                                                                          |      1  2.0|
      Follicular Cell, Hyperplasia         |                                                                          |      2  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Degeneration, Cystic                 |          2                                                               |      1  2.0|
      Hyperplasia                          |                                                                          |      3  2.7|
      Inflammation, Suppurative            |                                                                          |     11  2.5|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Corpus Luteum, Proliferation         |       3                                                                  |      1  3.0|
      Corpus Luteum, Thecal Cell,          |                                                                          |            |
          Hyperplasia                      |       3                                                                  |      1  3.0|
      Follicle, Cyst                       |                                                                          |      2  1.0|
      Periovarian Tissue, Cyst             |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hemorrhage                           |                                                                          |      2  3.5|
      Hydrometra                           |                                                                          |      2  1.5|
      Inflammation, Suppurative            |                         2                                                |      1  2.0|
      Endometrium, Hyperplasia, Cystic     |       1     1           2                                                |     27  1.3|
                                            __________________________________________________________________________|____________|
   Vagina                                  |                         +                                                |  10        |
      Cyst                                 |                         2                                                |      8  2.7|
      Inflammation, Suppurative            |                         2                                                |      4  3.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hypercellularity                     |                                                                          |      4  2.0|
      Myelofibrosis                        |                1                                                         |      4  1.3|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Mediastinal, Angiectasis             |                      2  1                                                |      9  1.6|
      Pancreatic, Angiectasis              |                                                                          |      1  2.0|
      Renal, Angiectasis                   |                      2                                                   |      1  2.0|
      Renal, Hyperplasia                   |                      1                                                   |      1  1.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Angiectasis                          |                                                                          |      3  1.7|
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  12                                                               
NTP Experiment-Test: 05089-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 16:21:47  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 6| 3| 3| 3| 3| 5| 5| 5| 5| 5|                                            |            |
                                           | 6| 1| 1| 1| 1| 7| 8| 8| 9| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                            |      A     |
    VEHICLE                                | 2| 2| 2| 2| 2| 4| 4| 4| 4| 4|                                            |      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia                          |                                                                          |      5  2.2|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Angiectasis                          |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hematopoietic Cell Proliferation     | 3  2                                                                     |     12  2.8|
      Hyperplasia, Histiocytic, Lymphoid   |       2                                                                  |      2  2.0|
      Capsule, Hyperplasia, Histiocytic,   |                                                                          |            |
           Lymphoid                        |             2                                                            |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Dilatation                           | 1        2  2                                                            |     40  2.0|
      Hyperplasia                          |                                                                          |      3  2.3|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Abscess                              |                                                                          |      1  3.0|
      Inflammation, Chronic                |                                                                          |      3  1.7|
      Ulcer                                |                                                                          |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperostosis                         |          3                                                               |     10  2.5|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Compression                          |          3                                                               |     11  2.7|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Congestion                           |                                                                          |      1  1.0|
      Foreign Body                         |                                                                          |      1  3.0|
      Hemorrhage                           |    2                                                                     |      1  2.0|
      Hyperplasia, Macrophage              |                                                                          |      3  1.7|
      Infiltration Cellular, Mixed Cell    |    2                                                                     |      3  2.0|
      Inflammation, Pyogranulomatous       |                                                                          |      1  3.0|
      Alveolar Epithelium, Hyperplasia     |                2  2                                                      |      4  1.8|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Foreign Body                         |                                                                          |      1  4.0|
      Fungus                               |                                                                          |      3  2.3|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  13                                                               
NTP Experiment-Test: 05089-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 16:21:47  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 6| 3| 3| 3| 3| 5| 5| 5| 5| 5|                                            |            |
                                           | 6| 1| 1| 1| 1| 7| 8| 8| 9| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|                                            |      A     |
    VEHICLE                                | 2| 2| 2| 2| 2| 4| 4| 4| 4| 4|                                            |      L     |
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Suppurative            |                1  2     2                                                |      6  2.2|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   3        |
      Cataract                             |                                                                          |      3  3.0|
      Retina, Degeneration                 |                                                                          |      2  3.5|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                      +                                                   |   5        |
      Hyperplasia, Lymphoid                |                      1                                                   |      5  1.8|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Mineralization                       |                      1  1  1                                             |      9  1.2|
      Nephropathy                          | 1  3  2  2  1  1  2  1  1  2                                             |     54  2.0|
      Renal Tubule, Vacuolization          |                                                                          |            |
          Cytoplasmic                      |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  14                                                               
NTP Experiment-Test: 05089-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 16:21:47  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |
                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |            |
                                           | 3| 3| 4| 4| 5| 3| 3| 4| 4| 5|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      A     |
    VEHICLE                                | 5| 5| 5| 5| 5| 3| 3| 3| 3| 3|                                            |      L     |
    3 SSAC                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Granuloma                            | 1  1  1                    1                                             |      4  1.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Cyst                                 |                   2                                                      |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  M  +  +  +  +                                             |   9        |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Hydrometra                           |             1        1  2                                                |      3  1.3|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  15                                                               
NTP Experiment-Test: 05089-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 16:21:47  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |
                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |            |
                                           | 3| 3| 4| 4| 5| 3| 3| 4| 4| 5|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      A     |
    VEHICLE                                | 5| 5| 5| 5| 5| 3| 3| 3| 3| 3|                                            |      L     |
    3 SSAC                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Myelofibrosis                        |                2           2                                             |      2  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |    +  +              +     +                                             |   4        |
      Hyperplasia, Glandular               |    2  2                    2                                             |      3  2.0|
      Hyperplasia, Lymphoid                |    2  2              2     3                                             |      4  2.3|
      Inflammation, Chronic                |    2  2              2     3                                             |      4  2.3|
      Metaplasia, Squamous                 |    2  2                    2                                             |      3  2.0|
      Necrosis                             |    2  2                    2                                             |      3  2.0|
      Acinus, Dilatation                   |                      2     1                                             |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Mineralization                       | 1  1  2     1  1  1  1  1  1                                             |      9  1.1|
      Nephropathy                          | 1                                                                        |      1  1.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  16                                                               
NTP Experiment-Test: 05089-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 16:21:47  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 6| 7| 7| 7| 5| 6| 7| 7| 7| 6| 6| 7| 7| 7|             
                             DAY ON TEST   | 1| 1| 2| 2| 2| 9| 2| 2| 2| 2| 0| 8| 2| 2| 2| 9| 8| 2| 2| 2| 9| 9| 0| 2| 2|             
                                           | 9| 2| 9| 9| 9| 1| 0| 2| 9| 9| 8| 7| 9| 9| 9| 2| 7| 9| 9| 9| 0| 0| 3| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    0.0200%                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |             2                    1                                       |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Congestion                           |    2                                                                     |             
      Fatty Change                         |                      1           1           2                 2  2      |             
      Focal Cellular Change                |                2        1  2     1  1  1  1     2  2  1  2  2  2  2  2  2|             
      Granuloma                            | 1  2  1  1           2  1  1  1  1  2  1  2     2  1  1  3     2  2  2  1|             
      Hematopoietic Cell Proliferation     |                1                                                         |             
      Hepatodiaphragmatic Nodule           |          3                                            3                  |             
      Hyperplasia, Histiocytic, Lymphoid   |                                                       2                  |             
      Hyperplasia, Multifocal              |    2        1     2  2                                      2     2      |             
      Infiltration Cellular, Mixed Cell    |                2        2                       2                        |             
      Inflammation, Focal                  |                                                       2                  |             
      Necrosis, Focal                      |                   2  2                                                   |             
      Bile Duct, Hyperplasia               |    1  1  2  2     3     1  1        1  1  1  2  1  1  1     2  2     1  1|             
      Biliary Tract, Fibrosis              |    1  1  2  2     2        1                 1     1  1     2        1   |             
      Centrilobular, Atrophy               |    2              2                          3                           |             
      Centrilobular, Necrosis              |                                              2              2            |             
                                            __________________________________________________________________________|             
   Mesentery                               |                +  +              +           +              +            |             
      Inflammation, Chronic                |                                  3                                       |             
      Fat, Necrosis                        |                3                             3                           |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy, Focal                       | 1                                                                        |             
      Duct, Dilatation                     |                   1                                                      |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +|             
      Diverticulum                         |                                                                          |             
      Inflammation, Chronic                |                                  3           2                           |             
      Perforation                          |                                  4                                       |             
      Ulcer                                |                                  4                                       |             
      Mucosa, Hyperplasia, Papillary       |                                  4           3                           |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  17                                                               
NTP Experiment-Test: 05089-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 16:21:47  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 6| 7| 7| 7| 5| 6| 7| 7| 7| 6| 6| 7| 7| 7|             
                             DAY ON TEST   | 1| 1| 2| 2| 2| 9| 2| 2| 2| 2| 0| 8| 2| 2| 2| 9| 8| 2| 2| 2| 9| 9| 0| 2| 2|             
                                           | 9| 2| 9| 9| 9| 1| 0| 2| 9| 9| 8| 7| 9| 9| 9| 2| 7| 9| 9| 9| 0| 0| 3| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    0.0200%                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Focal Cellular Change                |    2  1                    2     1  2           1  1  2           2      |             
      Hyperplasia                          |                                     3                                    |             
      Vacuolization Cytoplasmic            |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |       1                                                  1        2      |             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 4  3  2  2  3        2  2  2     2        2  3  1  2  3  3     3  3     1|             
      Cyst                                 |                   2                                                      |             
      Hemorrhage                           |                                                                          |             
      Pars Distalis, Focal Cellular Change |                                                                          |             
      Pars Distalis, Hyperplasia, Focal    |                         2                                                |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |                         2        1                                       |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 |                                                                          |             
      Hyperplasia                          |          3  2                                                            |             
      Inflammation, Suppurative            |       3  2                                                     3         |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Corpus Luteum, Proliferation         |                                                                          |             
      Corpus Luteum, Thecal Cell,          |                                                                          |             
          Hyperplasia                      |                                                                          |             
      Follicle, Cyst                       |                                                    2                     |             
      Periovarian Tissue, Cyst             |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                  2                                       |             
      Hydrometra                           |             2                                         2                 2|             
      Inflammation, Suppurative            |                                           2        3                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  18                                                               
NTP Experiment-Test: 05089-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 16:21:47  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 6| 7| 7| 7| 5| 6| 7| 7| 7| 6| 6| 7| 7| 7|             
                             DAY ON TEST   | 1| 1| 2| 2| 2| 9| 2| 2| 2| 2| 0| 8| 2| 2| 2| 9| 8| 2| 2| 2| 9| 9| 0| 2| 2|             
                                           | 9| 2| 9| 9| 9| 1| 0| 2| 9| 9| 8| 7| 9| 9| 9| 2| 7| 9| 9| 9| 0| 0| 3| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    0.0200%                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Cervix, Lamina Propria, Hyperplasia  |                                                                          |             
      Endometrium, Hyperplasia, Cystic     |    2        2                 2           2     2     2                 2|             
      Horn, Atrophy                        |                                     4                                    |             
      Serosa, Inflammation, Chronic        |                                                                          |             
                                            __________________________________________________________________________|             
   Vagina                                  |          +  +  +  +                          +        +                  |             
      Cyst                                 |          3  2     2                                   X                  |             
      Inflammation, Suppurative            |          3                                                               |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hypercellularity                     |                3                                                         |             
      Myelofibrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inguinal, Angiectasis                |                                                                          |             
      Inguinal, Hyperplasia                |                                                                          |             
      Inguinal, Inflammation, Suppurative  |                      3                                                   |             
      Mediastinal, Angiectasis             | 3        2     2                                         3               |             
      Pancreatic, Angiectasis              |                                                          2               |             
      Pancreatic, Hyperplasia, Lymphoid    |                                                                          |             
      Renal, Angiectasis                   | 2                                                                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Hyperplasia                          |                2                                                         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |       2                                                           2      |             
      Hyperplasia, Histiocytic             |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
      Hematopoietic Cell Proliferation     |                4     3  3  2        2           2  2                     |             
      Hyperplasia, Histiocytic, Lymphoid   |       2                             2                    3           1   |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           | 2  2  2  2  1     2  3     2     2  2     2  2     2  1  1  1  3  4     2|             
      Hyperplasia                          |    2                 3                                         3         |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Ulcer                                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperostosis                         |                1        2                    3                           |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  19                                                               
NTP Experiment-Test: 05089-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 16:21:47  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 5| 6| 7| 7| 7| 5| 6| 7| 7| 7| 5| 6| 7| 7| 7| 6| 6| 7| 7| 7|             
                             DAY ON TEST   | 1| 1| 2| 2| 2| 9| 2| 2| 2| 2| 0| 8| 2| 2| 2| 9| 8| 2| 2| 2| 9| 9| 0| 2| 2|             
                                           | 9| 2| 9| 9| 9| 1| 0| 2| 9| 9| 8| 7| 9| 9| 9| 2| 7| 9| 9| 9| 0| 0| 3| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    0.0200%                                | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          | 3  3                 3                       2                 3  3      |             
      Hemorrhage                           |                                                             2            |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Macrophage              |                                                                          |             
      Infiltration Cellular, Mixed Cell    |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                           1           3                  |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fungus                               |                                                                      2   |             
      Inflammation, Suppurative            |                                                                      2   |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |    +                             +        +              +           +   |             
      Atrophy                              |                                                          4               |             
      Cataract                             |    3                             3        3                          4   |             
      Retina, Degeneration                 |    4                             3        3              4           4   |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                               3                                          |             
      Cyst                                 |          4              2              2                                 |             
      Hydronephrosis                       |                               3                                          |             
      Inflammation, Suppurative            |                               3                                          |             
      Mineralization                       |                                                                          |             
      Nephropathy                          | 2  4  3  3  3  2  2  3  4  3  4  4  3  2  1  2  2  3  2  1  3  3  3  4  2|             
      Pelvis, Transitional Epithelium,     |                                                                          |             
           Hyperplasia                     |                               3                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  20                                                               
NTP Experiment-Test: 05089-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 16:21:47  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 6| 7| 7| 7| 7| 6| 5| 7| 7| 7| 5| 6| 6| 7| 7| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 5| 5| 5| 5| 5| 6| 2| 2| 2| 2| 2| 8| 1| 2| 2| 0| 1| 9| 2| 2| 8| 0| 2| 2| 2|             
                                           | 7| 7| 8| 9| 9| 9| 9| 9| 9| 9| 1| 9| 9| 9| 9| 8| 8| 4| 5| 9| 9| 4| 9| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    0.0200%                                | 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |       2              1                 1                                 |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                        2                                 |             
      Congestion                           |                                                                          |             
      Fatty Change                         |                3                    2           3              2         |             
      Focal Cellular Change                |    1        1        1  1  2  1  2     2  2        2     2  1     1  1   |             
      Granuloma                            | 1  2  1  1  1     1     2  1  2  2     1     1     2     1  2     2  1  1|             
      Hematopoietic Cell Proliferation     |                                              2                           |             
      Hepatodiaphragmatic Nodule           |    3                    2        2                 3              3      |             
      Hyperplasia, Histiocytic, Lymphoid   |                                                                   2      |             
      Hyperplasia, Multifocal              |                2     2              2           3     2  2     2         |             
      Infiltration Cellular, Mixed Cell    |                   2              2        2              2  2            |             
      Inflammation, Focal                  |                                                                          |             
      Necrosis, Focal                      |                                        1                                 |             
      Bile Duct, Hyperplasia               | 1     1  1  1  2  2  2  1  1     1              2     1  2  1     2  1  1|             
      Biliary Tract, Fibrosis              |             1  1  1     1  1                             1  1     2  1  1|             
      Centrilobular, Atrophy               |                2                    2           4              2         |             
      Centrilobular, Necrosis              |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                +                                +                       +|             
      Inflammation, Chronic                |                                                                          |             
      Fat, Necrosis                        |                                                                         3|             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy, Focal                       |                1                                                     1   |             
      Duct, Dilatation                     |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                               2                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Diverticulum                         |                                                                          |             
      Inflammation, Chronic                |                                                 3              3         |             
      Perforation                          |                                                                          |             
      Ulcer                                |                                                 3              3         |             
      Mucosa, Hyperplasia, Papillary       |                            1                    3              2         |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  21                                                               
NTP Experiment-Test: 05089-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 16:21:47  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 6| 7| 7| 7| 7| 6| 5| 7| 7| 7| 5| 6| 6| 7| 7| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 5| 5| 5| 5| 5| 6| 2| 2| 2| 2| 2| 8| 1| 2| 2| 0| 1| 9| 2| 2| 8| 0| 2| 2| 2|             
                                           | 7| 7| 8| 9| 9| 9| 9| 9| 9| 9| 1| 9| 9| 9| 9| 8| 8| 4| 5| 9| 9| 4| 9| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    0.0200%                                | 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Focal Cellular Change                |                      1        1                       2              2   |             
      Hyperplasia                          |                                        4                                 |             
      Vacuolization Cytoplasmic            |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                2     2     1                    2           1            |             
      Infiltration Cellular, Lymphocyte    |                                                    2                     |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                             2            |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |    2  2        3  1  2  3  2     2  2  3  2     2  2  3  3  3     2  3  2|             
      Cyst                                 |                                              3     2                     |             
      Hemorrhage                           |                                                       3                  |             
      Pars Distalis, Focal Cellular Change |                                                                          |             
      Pars Distalis, Hyperplasia, Focal    |       2                                                                  |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  | 1  1  1  1  2           1                                                |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 |                                                             2            |             
      Hyperplasia                          |                                                          1               |             
      Inflammation, Suppurative            |    2                                         4                           |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Corpus Luteum, Proliferation         |                                           2                              |             
      Corpus Luteum, Thecal Cell,          |                                                                          |             
          Hyperplasia                      |                                           3                              |             
      Follicle, Cyst                       |                                                                      1   |             
      Periovarian Tissue, Cyst             |             3                                                           3|             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |       2                                                                  |             
      Hydrometra                           |    2                                      2                 1            |             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  22                                                               
NTP Experiment-Test: 05089-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 16:21:47  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 6| 7| 7| 7| 7| 6| 5| 7| 7| 7| 5| 6| 6| 7| 7| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 5| 5| 5| 5| 5| 6| 2| 2| 2| 2| 2| 8| 1| 2| 2| 0| 1| 9| 2| 2| 8| 0| 2| 2| 2|             
                                           | 7| 7| 8| 9| 9| 9| 9| 9| 9| 9| 1| 9| 9| 9| 9| 8| 8| 4| 5| 9| 9| 4| 9| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    0.0200%                                | 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Cervix, Lamina Propria, Hyperplasia  |                                           2                              |             
      Endometrium, Hyperplasia, Cystic     |       2           2     3  2  2     1     1     2           2     1     1|             
      Horn, Atrophy                        |                                                                          |             
      Serosa, Inflammation, Chronic        |                                                                          |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                     +           +                       +|             
      Cyst                                 |                                     X                                   X|             
      Inflammation, Suppurative            |                                     1                                    |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hypercellularity                     |                                  3           3              3            |             
      Myelofibrosis                        |          1                                                               |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inguinal, Angiectasis                |                   3                                                      |             
      Inguinal, Hyperplasia                |                   2                          2                           |             
      Inguinal, Inflammation, Suppurative  |                                                                          |             
      Mediastinal, Angiectasis             | 1  2        1                                   2              2         |             
      Pancreatic, Angiectasis              |                                                                          |             
      Pancreatic, Hyperplasia, Lymphoid    |                                                                          |             
      Renal, Angiectasis                   |                                                 3                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                           2                 1            |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                    2                     |             
      Hyperplasia, Histiocytic             |          2                                                               |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                      2                                                   |             
      Hematopoietic Cell Proliferation     |                                              4                    2      |             
      Hyperplasia, Histiocytic, Lymphoid   |                                  1                                2      |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                   1     2  2  2        2  2  2  2  2  2     2  2  2  2  4|             
      Hyperplasia                          |                            1           2              2     2            |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                               2                                          |             
      Ulcer                                |                               1                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperostosis                         |                3     3     2        2              2        3            |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  23                                                               
NTP Experiment-Test: 05089-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 16:21:47  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 6| 7| 7| 7| 7| 6| 5| 7| 7| 7| 5| 6| 6| 7| 7| 5| 7| 7| 7| 7|             
                             DAY ON TEST   | 5| 5| 5| 5| 5| 6| 2| 2| 2| 2| 2| 8| 1| 2| 2| 0| 1| 9| 2| 2| 8| 0| 2| 2| 2|             
                                           | 7| 7| 8| 9| 9| 9| 9| 9| 9| 9| 1| 9| 9| 9| 9| 8| 8| 4| 5| 9| 9| 4| 9| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    0.0200%                                | 3| 3| 3| 3| 3| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                                                       2                  |             
      Hemorrhage                           |                                                                3         |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                               2                                          |             
      Hemorrhage                           |                               1                       3                  |             
      Hyperplasia, Macrophage              |                            2           2                                2|             
      Infiltration Cellular, Mixed Cell    |                                           2  2           2               |             
      Alveolar Epithelium, Hyperplasia     |       2                                         2              2         |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fungus                               |                                                       2        2         |             
      Inflammation, Suppurative            |                                                       2        2         |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |    +                                                                     |             
      Atrophy                              |                                                                          |             
      Cataract                             |    4                                                                     |             
      Retina, Degeneration                 |    4                                                                     |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |             +                                                            |             
      Hyperplasia, Lymphoid                |             2                                                            |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Cyst                                 |                                                                          |             
      Hydronephrosis                       |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Mineralization                       | 1     1  1  2                                                            |             
      Nephropathy                          | 1  1  1  1  1  3  1  2  2  2  2  1  2  3  2  1  1  1  3  3  4  3  2  3  3|             
      Pelvis, Transitional Epithelium,     |                                                                          |             
           Hyperplasia                     |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  24                                                               
NTP Experiment-Test: 05089-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 16:21:47  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 6| 6| 6| 7| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 6| 6| 8| 8| 2| 5| 5| 5| 5| 5|                                            |            |
                                           | 5| 2| 7| 7| 9| 7| 7| 8| 8| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|                                            |      A     |
    0.0200%                                | 9| 9| 9| 9| 9| 1| 1| 1| 1| 1|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Parasite Metazoan                    |                                                                          |      5  1.4|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Angiectasis                          |             2                                                            |      2  2.0|
      Congestion                           |                                                                          |      1  2.0|
      Fatty Change                         |    3  3                                                                  |     11  2.2|
      Focal Cellular Change                |          1  2  1                                                         |     33  1.5|
      Granuloma                            | 1        1  1        2  1  2                                             |     44  1.4|
      Hematopoietic Cell Proliferation     |                                                                          |      2  1.5|
      Hepatodiaphragmatic Nodule           | 3                 2                                                      |      9  2.7|
      Hyperplasia, Histiocytic, Lymphoid   |                                                                          |      2  2.0|
      Hyperplasia, Multifocal              |    2  2                                                                  |     15  2.0|
      Infiltration Cellular, Mixed Cell    | 2                                                                        |      9  2.0|
      Inflammation, Focal                  |                                                                          |      1  2.0|
      Necrosis, Focal                      |                                                                          |      3  1.7|
      Bile Duct, Hyperplasia               |    1  2  1  1  1     2     1                                             |     42  1.4|
      Biliary Tract, Fibrosis              |    1  2  1  1        2                                                   |     26  1.3|
      Centrilobular, Atrophy               |    3  3                                                                  |      9  2.6|
      Centrilobular, Necrosis              |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |    +                                                                     |   9        |
      Inflammation, Chronic                |                                                                          |      1  3.0|
      Fat, Necrosis                        |                                                                          |      3  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Atrophy, Focal                       | 1                 2        2                                             |      6  1.3|
      Duct, Dilatation                     |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Mineralization                       |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Diverticulum                         |                            3                                             |      1  3.0|
      Inflammation, Chronic                |    3                                                                     |      5  2.8|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  25                                                               
NTP Experiment-Test: 05089-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 16:21:47  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 6| 6| 6| 7| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 6| 6| 8| 8| 2| 5| 5| 5| 5| 5|                                            |            |
                                           | 5| 2| 7| 7| 9| 7| 7| 8| 8| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|                                            |      A     |
    0.0200%                                | 9| 9| 9| 9| 9| 1| 1| 1| 1| 1|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Perforation                          |                                                                          |      1  4.0|
      Ulcer                                |    3                                                                     |      4  3.3|
      Mucosa, Hyperplasia, Papillary       |    3                                                                     |      6  2.7|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inflammation, Chronic                |    2                                                                     |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Focal Cellular Change                |    1  2     3              1                                             |     17  1.6|
      Hyperplasia                          |                                                                          |      2  3.5|
      Vacuolization Cytoplasmic            |    3                                                                     |      1  3.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperplasia                          |             1                                                            |      9  1.4|
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Angiectasis                          | 3  3  3  2  3  1  2  2  2  2                                             |     47  2.3|
      Cyst                                 |                                                                          |      3  2.3|
      Hemorrhage                           |                                                                          |      1  3.0|
      Pars Distalis, Focal Cellular Change |                1  2                                                      |      2  1.5|
      Pars Distalis, Hyperplasia, Focal    |             2           2                                                |      4  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      C-Cell, Hyperplasia                  |       2        1  1  1  2  1                                             |     14  1.3|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Degeneration, Cystic                 |                   2                                                      |      2  2.0|
      Hyperplasia                          |                                                                          |      3  2.0|
      Inflammation, Suppurative            |          1                                                               |      6  2.5|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  26                                                               
NTP Experiment-Test: 05089-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 16:21:47  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 6| 6| 6| 7| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 6| 6| 8| 8| 2| 5| 5| 5| 5| 5|                                            |            |
                                           | 5| 2| 7| 7| 9| 7| 7| 8| 8| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|                                            |      A     |
    0.0200%                                | 9| 9| 9| 9| 9| 1| 1| 1| 1| 1|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Angiectasis                          |          2                                                               |      1  2.0|
      Corpus Luteum, Proliferation         |                                                                          |      1  2.0|
      Corpus Luteum, Thecal Cell,          |                                                                          |            |
          Hyperplasia                      |                                                                          |      1  3.0|
      Follicle, Cyst                       |                                                                          |      2  1.5|
      Periovarian Tissue, Cyst             | 3                                                                        |      3  3.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cyst                                 |                                                                          |      2  2.0|
      Hydrometra                           |                      1     3                                             |      8  1.9|
      Inflammation, Suppurative            |                                                                          |      2  2.5|
      Cervix, Lamina Propria, Hyperplasia  |                                                                          |      1  2.0|
      Endometrium, Hyperplasia, Cystic     | 2                    2                                                   |     20  1.9|
      Horn, Atrophy                        |                                                                          |      1  4.0|
      Serosa, Inflammation, Chronic        |                      2                                                   |      1  2.0|
                                            __________________________________________________________________________|____________|
   Vagina                                  |    +  +  +           +                                                   |  13        |
      Cyst                                 |          3           3                                                   |      8  2.6|
      Inflammation, Suppurative            |                      2                                                   |      3  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hypercellularity                     | 2                                                                        |      5  2.8|
      Myelofibrosis                        |                      3  1                                                |      3  1.7|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inguinal, Angiectasis                |                                                                          |      1  3.0|
      Inguinal, Hyperplasia                |                                                                          |      2  2.0|
      Inguinal, Inflammation, Suppurative  |                                                                          |      1  3.0|
      Mediastinal, Angiectasis             |          2           1  2  2                                             |     13  1.9|
      Pancreatic, Angiectasis              |                                                                          |      1  2.0|
      Pancreatic, Hyperplasia, Lymphoid    |                      2                                                   |      1  2.0|
      Renal, Angiectasis                   |                      3                                                   |      3  2.7|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Angiectasis                          |                                                                          |      2  1.5|
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Angiectasis                          |                      2                                                   |      4  2.0|
      Hyperplasia, Histiocytic             |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Fibrosis                             |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     |                                                                          |      9  2.7|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  27                                                               
NTP Experiment-Test: 05089-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 16:21:47  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 6| 6| 6| 7| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 6| 6| 8| 8| 2| 5| 5| 5| 5| 5|                                            |            |
                                           | 5| 2| 7| 7| 9| 7| 7| 8| 8| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|                                            |      A     |
    0.0200%                                | 9| 9| 9| 9| 9| 1| 1| 1| 1| 1|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia, Histiocytic, Lymphoid   |                                                                          |      6  1.8|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Dilatation                           |    2  1  2  2                                                            |     38  2.0|
      Hyperplasia                          |                                                                          |      7  2.1|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Ulcer                                |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperostosis                         |                                                                          |      9  2.3|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Compression                          |                                                                          |      7  2.7|
      Hemorrhage                           |    3                                                                     |      3  2.7|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Congestion                           |                                                                          |      1  2.0|
      Hemorrhage                           |                                                                          |      2  2.0|
      Hyperplasia, Macrophage              |                                                                          |      3  2.0|
      Infiltration Cellular, Mixed Cell    | 2                                                                        |      4  2.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      5  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Fungus                               |                                                                          |      3  2.0|
      Inflammation, Suppurative            | 1                                                                        |      4  1.8|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |    +                                                                     |   7        |
      Atrophy                              |    4                                                                     |      2  4.0|
      Cataract                             |                                                                          |      5  3.4|
      Retina, Degeneration                 |    4                                                                     |      7  3.7|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                +     +     +                                             |   4        |
      Hyperplasia, Lymphoid                |                1     2     1                                             |      4  1.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  28                                                               
NTP Experiment-Test: 05089-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 16:21:47  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 6| 6| 6| 7| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 6| 6| 8| 8| 2| 5| 5| 5| 5| 5|                                            |            |
                                           | 5| 2| 7| 7| 9| 7| 7| 8| 8| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|                                            |      A     |
    0.0200%                                | 9| 9| 9| 9| 9| 1| 1| 1| 1| 1|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Atrophy                              |                                                                          |      1  3.0|
      Cyst                                 |                                                                          |      3  2.7|
      Hydronephrosis                       |                                                                          |      1  3.0|
      Inflammation, Suppurative            |                                                                          |      1  3.0|
      Mineralization                       |                1        1  1                                             |      7  1.1|
      Nephropathy                          |    2  2  2  2  2  3  1  1  1                                             |     59  2.3|
      Pelvis, Transitional Epithelium,     |                                                                          |            |
           Hyperplasia                     |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  29                                                               
NTP Experiment-Test: 05089-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 16:21:47  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |
                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |            |
                                           | 3| 3| 4| 4| 5| 3| 3| 4| 4| 5|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|                                            |      A     |
    0.0200%                                | 2| 2| 2| 2| 2| 0| 0| 0| 0| 0|                                            |      L     |
    3 SSAC                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Granuloma                            |          1        1     1  1                                             |      4  1.0|
      Hepatodiaphragmatic Nodule           | 2                                                                        |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Tooth                                   |                         +                                                |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  M  +  +  +  +  +  +  M  +                                             |   8        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Hydrometra                           |                      2                                                   |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  30                                                               
NTP Experiment-Test: 05089-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 16:21:47  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |
                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |            |
                                           | 3| 3| 4| 4| 5| 3| 3| 4| 4| 5|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|                                            |      A     |
    0.0200%                                | 2| 2| 2| 2| 2| 0| 0| 0| 0| 0|                                            |      L     |
    3 SSAC                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Myelofibrosis                        |                1           2                                             |      2  1.5|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Atrophy                              |                      4                                                   |      1  4.0|
      Hydrocephalus                        |                      3                                                   |      1  3.0|
      Mineralization, Focal                |                      3                                                   |      1  3.0|
      Necrosis                             |                      3                                                   |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |          +                                                               |   1        |
      Hemorrhage                           |          4                                                               |      1  4.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |       +     +  +     +  +                                                |   5        |
      Hyperplasia, Glandular               |                      2                                                   |      1  2.0|
      Hyperplasia, Lymphoid                |             1        2  1                                                |      3  1.3|
      Inflammation, Chronic                |             1        2  1                                                |      3  1.3|
      Acinus, Dilatation                   |       1        2     1                                                   |      3  1.3|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  31                                                               
NTP Experiment-Test: 05089-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 16:21:47  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |
                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |            |
                                           | 3| 3| 4| 4| 5| 3| 3| 4| 4| 5|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|                                            |      A     |
    0.0200%                                | 2| 2| 2| 2| 2| 0| 0| 0| 0| 0|                                            |      L     |
    3 SSAC                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Mineralization                       | 1  1  2  1  1  1  1  2  1  1                                             |     10  1.2|
      Nephropathy                          |    1                       1                                             |      2  1.0|
      Renal Tubule, Dilatation             |    1                                                                     |      1  1.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  32                                                               
NTP Experiment-Test: 05089-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 16:21:47  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7|             
                             DAY ON TEST   | 9| 2| 3| 3| 3| 1| 3| 3| 3| 3| 8| 6| 3| 3| 3| 0| 3| 3| 3| 3| 0| 7| 3| 3| 3|             
                                           | 0| 0| 2| 2| 2| 9| 2| 2| 2| 2| 4| 8| 2| 2| 2| 5| 1| 1| 1| 1| 9| 6| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    0.0100%                                | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |             2                                               1            |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                              2     1                     |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                           2        2                     |             
      Cyst                                 |                   2                                                      |             
      Fatty Change                         |    2           1     1        3  2                                       |             
      Focal Cellular Change                |    1  2  1  1     2  1  1  1     2  2  2  2  1  2  2     1           2   |             
      Granuloma                            | 2  1  2     2  1     1  2  1     1  2  1  1  1  2  2  3     1        1  1|             
      Hematopoietic Cell Proliferation     |    2                                         2                           |             
      Hepatodiaphragmatic Nodule           |                   2           3                                2         |             
      Hyperplasia, Multifocal              |                               2                          1     2  2      |             
      Infiltration Cellular, Mixed Cell    |                                  2     2                                 |             
      Necrosis, Focal                      |                                                                          |             
      Bile Duct, Hyperplasia               | 2  1  1  1  2  1  2  1     1  2        2  1     1  1  1  3     2  2  1   |             
      Biliary Tract, Fibrosis              | 2     1     2  1  1  1     1  1        1  1        1  2  3     1  2      |             
      Centrilobular, Atrophy               |                               3                                2         |             
      Centrilobular, Necrosis              |                                                             2            |             
                                            __________________________________________________________________________|             
   Mesentery                               |                +              +                                          |             
      Inflammation, Chronic                |                3                                                         |             
      Fat, Necrosis                        |                               3                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy, Focal                       | 3  2                 1           1           1  1                        |             
      Edema                                |                                                             2            |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                    1                     |             
      Edema                                |                               2                                          |             
      Inflammation, Chronic                |                3              2                                          |             
      Perforation                          |                4                                                         |             
      Ulcer                                |                4                                                         |             
      Mucosa, Hyperplasia, Papillary       |                4              2                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                               2                                          |             
      Erosion                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  33                                                               
NTP Experiment-Test: 05089-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 16:21:47  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7|             
                             DAY ON TEST   | 9| 2| 3| 3| 3| 1| 3| 3| 3| 3| 8| 6| 3| 3| 3| 0| 3| 3| 3| 3| 0| 7| 3| 3| 3|             
                                           | 0| 0| 2| 2| 2| 9| 2| 2| 2| 2| 4| 8| 2| 2| 2| 5| 1| 1| 1| 1| 9| 6| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    0.0100%                                | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Mucosa, Hyperplasia                  |                                              2                           |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Thrombosis                           |                               3                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Congestion                           |                                                                          |             
      Degeneration                         |                               3                                          |             
      Fibrosis                             |             2                                                            |             
      Focal Cellular Change                |    2     1     2  2  2  2        1     2                 1               |             
      Vacuolization Cytoplasmic            |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |             1                    2        2     2                        |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 2  2  2  2  1  2  2  1  1  2     2     3  1  2  2  2     2     2  4     3|             
      Cyst                                 |                                     2                                    |             
      Pars Distalis, Hyperplasia, Focal    |             2        2        2                                   2  2   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |       1     1                             2        2                     |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 |                                                 2                        |             
      Hyperplasia                          |                   2                             2        2               |             
      Inflammation, Suppurative            |    1              2                                      2               |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicle, Cyst                       |                         3                                                |             
      Periovarian Tissue, Cyst             |                                                    X                     |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Decidual Reaction                    |                                                                      3   |             
      Hydrometra                           |          3                       3                 2     2               |             
      Inflammation, Suppurative            |                                     1                             3      |             
      Endometrium, Hyperplasia, Cystic     | 1        2  1           1  1  2  1  1     2  2  1  2  1  2  2  1  3     2|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  34                                                               
NTP Experiment-Test: 05089-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 16:21:47  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7|             
                             DAY ON TEST   | 9| 2| 3| 3| 3| 1| 3| 3| 3| 3| 8| 6| 3| 3| 3| 0| 3| 3| 3| 3| 0| 7| 3| 3| 3|             
                                           | 0| 0| 2| 2| 2| 9| 2| 2| 2| 2| 4| 8| 2| 2| 2| 5| 1| 1| 1| 1| 9| 6| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    0.0100%                                | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Vagina                                  |       +                    +                 +                          +|             
      Cyst                                 |       3                    2                                            3|             
      Inflammation, Suppurative            |                            2                                            3|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hypercellularity                     |    3  2                          3     2     3                           |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inguinal, Hyperplasia                |                                        3                                 |             
      Mediastinal, Angiectasis             |       2                             3                                    |             
      Mediastinal, Hyperplasia             |                                              3                           |             
      Pancreatic, Angiectasis              |                               4     2                                    |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 2                                                                        |             
      Hyperplasia                          |                            2                                             |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |       3                 2                                                |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Depletion Cellular                   |                                        2                    1            |             
      Developmental Malformation           |                                                                          |             
      Fibrosis                             |                               3                                          |             
      Hematopoietic Cell Proliferation     |    4                             4           4                       2   |             
      Hyperplasia, Histiocytic, Lymphoid   |                                     4                                    |             
      Necrosis, Focal                      |                               3                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |       2                                                        2         |             
      Epithelial Cell, Hyperplasia         |                                                                   3      |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           | 2     1  2  2  2  2  2  2  2  2  2  2  3  2  2  2  2  2  2     1  3  2  2|             
      Fibrosis                             |                            2                                             |             
      Hyperplasia                          |                2           2  2                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                          |             
      Exudate                              |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Ulcer                                |                                                                          |             
      Sebaceous Gland, Cyst                |                                                                          |             
      Subcutaneous Tissue, Foreign Body    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  35                                                               
NTP Experiment-Test: 05089-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 16:21:47  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 6| 7| 7| 7| 6| 7| 7| 7| 7| 5| 6| 7| 7| 7|             
                             DAY ON TEST   | 9| 2| 3| 3| 3| 1| 3| 3| 3| 3| 8| 6| 3| 3| 3| 0| 3| 3| 3| 3| 0| 7| 3| 3| 3|             
                                           | 0| 0| 2| 2| 2| 9| 2| 2| 2| 2| 4| 8| 2| 2| 2| 5| 1| 1| 1| 1| 9| 6| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    0.0100%                                | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
      Hyperostosis                         |                2           1                       2           2         |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                                                    2                     |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                            2                                             |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Macrophage              |                                                                2         |             
      Alveolar Epithelium, Hyperplasia     |                                        2           3           1         |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fungus                               |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                +                                                         |             
      Cataract                             |                4                                                         |             
      Hemorrhage                           |                                                                          |             
      Retina, Degeneration                 |                3                                                         |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Mineralization                       | 1                                                                        |             
      Nephropathy                          | 1  2  2  2  2  4  3  2  2  3  3  1  3  3  2  1  2  2  2  3  1  2  2  3  3|             
      Pigmentation                         |                                                                          |             
      Pelvis, Transitional Epithelium,     |                                                                          |             
           Hyperplasia                     |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                             3            |             
      Inflammation, Chronic                |                                                                          |             
      Transitional Epithelium, Hyperplasia |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  36                                                               
NTP Experiment-Test: 05089-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 16:21:47  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 2| 6| 7| 7| 7| 4| 6| 6| 7| 7|             
                             DAY ON TEST   | 5| 5| 5| 5| 5| 6| 1| 2| 3| 3| 9| 0| 3| 3| 3| 0| 1| 3| 3| 3| 6| 6| 9| 3| 3|             
                                           | 7| 7| 8| 8| 9| 0| 9| 6| 2| 2| 8| 4| 2| 2| 2| 0| 9| 2| 2| 2| 5| 7| 8| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    0.0100%                                | 0| 0| 0| 0| 0| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                 1                        |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                           1                              |             
                                            __________________________________________________________________________|             
   Intestine Small                         |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                         2                                                |             
      Cyst                                 |                                                                          |             
      Fatty Change                         |                4  3           2  3              2              4        1|             
      Focal Cellular Change                |                      1  2     2     1  2  2     2  2  2  2        2  1   |             
      Granuloma                            |                   1  1  1  1  1  1     1        3     2  1        1  2  1|             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hepatodiaphragmatic Nodule           |                   3                                   3              2   |             
      Hyperplasia, Multifocal              |                2     1                             2                     |             
      Infiltration Cellular, Mixed Cell    |                                                       2                  |             
      Necrosis, Focal                      |                                              2                           |             
      Bile Duct, Hyperplasia               |                         2  1  1        1  1  1     1  1  1  1  2  1  2   |             
      Biliary Tract, Fibrosis              |                         1  1           1     1        1  1     2  1  1   |             
      Centrilobular, Atrophy               |                                                                2         |             
      Centrilobular, Necrosis              |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                   +              +                                       |             
      Inflammation, Chronic                |                   2              3                                       |             
      Fat, Necrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |                +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy, Focal                       |                   1                                                      |             
      Edema                                |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Edema                                |                                                                          |             
      Inflammation, Chronic                |                2  3              4                                       |             
      Perforation                          |                                                                          |             
      Ulcer                                |                   3              4                                       |             
      Mucosa, Hyperplasia, Papillary       |                1  4              4                                       |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Erosion                              |                2                                                         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  37                                                               
NTP Experiment-Test: 05089-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 16:21:47  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 2| 6| 7| 7| 7| 4| 6| 6| 7| 7|             
                             DAY ON TEST   | 5| 5| 5| 5| 5| 6| 1| 2| 3| 3| 9| 0| 3| 3| 3| 0| 1| 3| 3| 3| 6| 6| 9| 3| 3|             
                                           | 7| 7| 8| 8| 9| 0| 9| 6| 2| 2| 8| 4| 2| 2| 2| 0| 9| 2| 2| 2| 5| 7| 8| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    0.0100%                                | 0| 0| 0| 0| 0| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Inflammation, Chronic                |                   2              2                                       |             
      Mucosa, Hyperplasia                  |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |                         +                                                |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Thrombosis                           |                                                                2         |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Congestion                           |                                                             2            |             
      Degeneration                         |                                                                          |             
      Fibrosis                             |                                                                          |             
      Focal Cellular Change                |                1  1           1     1                    2               |             
      Vacuolization Cytoplasmic            |                2                 2                                       |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                      1        1                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |                +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                      3  2  3  3  2  3  3        3  3  2  3     2  2  2   |             
      Cyst                                 |                                                             3           3|             
      Pars Distalis, Hyperplasia, Focal    |                                     2                 2           2      |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |                   1  1  1              1  1                       1      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 |                               2                                          |             
      Hyperplasia                          |                               2           2                              |             
      Inflammation, Suppurative            |                                           3  1           1     3  1     3|             
                                            __________________________________________________________________________|             
   Ovary                                   |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicle, Cyst                       |                                                                          |             
      Periovarian Tissue, Cyst             |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Decidual Reaction                    |                                                                          |             
      Hydrometra                           |                                           3                              |             
      Inflammation, Suppurative            |                                                                          |             
      Endometrium, Hyperplasia, Cystic     |                         1  2  2  2  1  1  2  2  1  2  1  1  2  1  1     1|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  38                                                               
NTP Experiment-Test: 05089-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 16:21:47  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 2| 6| 7| 7| 7| 4| 6| 6| 7| 7|             
                             DAY ON TEST   | 5| 5| 5| 5| 5| 6| 1| 2| 3| 3| 9| 0| 3| 3| 3| 0| 1| 3| 3| 3| 6| 6| 9| 3| 3|             
                                           | 7| 7| 8| 8| 9| 0| 9| 6| 2| 2| 8| 4| 2| 2| 2| 0| 9| 2| 2| 2| 5| 7| 8| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    0.0100%                                | 0| 0| 0| 0| 0| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Vagina                                  |                +  +        +                       +  +                  |             
      Cyst                                 |                2  3        1                       3  3                  |             
      Inflammation, Suppurative            |                2  3                                4  2                  |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hypercellularity                     |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inguinal, Hyperplasia                |                                           2                              |             
      Mediastinal, Angiectasis             |                2                 2           2        3                  |             
      Mediastinal, Hyperplasia             |                                                                          |             
      Pancreatic, Angiectasis              |                                                 2                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                    2        2            |             
      Hyperplasia                          |                         2                                                |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                          3               |             
                                            __________________________________________________________________________|             
   Spleen                                  |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Depletion Cellular                   |                                                                          |             
      Developmental Malformation           |                                                                2         |             
      Fibrosis                             |                                                                          |             
      Hematopoietic Cell Proliferation     |                   3                       2                              |             
      Hyperplasia, Histiocytic, Lymphoid   |                         1                                                |             
      Necrosis, Focal                      |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  |                +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Epithelial Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                1  2  2  2  2  2  2  2  2  2     2        2     2     2  2|             
      Fibrosis                             |                                                                          |             
      Hyperplasia                          |                                                    2                    2|             
                                            __________________________________________________________________________|             
   Skin                                    |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                          |             
      Exudate                              |                                                                          |             
      Hemorrhage                           |                                                             2            |             
      Inflammation, Chronic                |                                                             2            |             
      Ulcer                                |                                                             2            |             
      Sebaceous Gland, Cyst                |                                                                      2   |             
      Subcutaneous Tissue, Foreign Body    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  39                                                               
NTP Experiment-Test: 05089-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 16:21:47  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 2| 6| 7| 7| 7| 4| 6| 6| 7| 7|             
                             DAY ON TEST   | 5| 5| 5| 5| 5| 6| 1| 2| 3| 3| 9| 0| 3| 3| 3| 0| 1| 3| 3| 3| 6| 6| 9| 3| 3|             
                                           | 7| 7| 8| 8| 9| 0| 9| 6| 2| 2| 8| 4| 2| 2| 2| 0| 9| 2| 2| 2| 5| 7| 8| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    0.0100%                                | 0| 0| 0| 0| 0| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
      Hyperostosis                         |                2     1  2  2        2              2                     |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |                +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                            2  3  1              3                        |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hemorrhage                           |                                     2                                    |             
      Hyperplasia, Macrophage              |                                                                      1   |             
      Alveolar Epithelium, Hyperplasia     |                   2                                                      |             
                                            __________________________________________________________________________|             
   Nose                                    |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fungus                               |                   2                                1                     |             
      Inflammation, Suppurative            |                   2                                1                     |             
                                            __________________________________________________________________________|             
   Trachea                                 |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                    +                     |             
                                            __________________________________________________________________________|             
   Eye                                     |                            +                                            +|             
      Cataract                             |                            3                                            2|             
      Hemorrhage                           |                                                                         3|             
      Retina, Degeneration                 |                                                                         3|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Inflammation, Suppurative            |                                           3                              |             
      Mineralization                       |                                                                          |             
      Nephropathy                          |                1  1  3  2  2  2  4  2  2  2  1  2  1  2  1  1  1  1  2  4|             
      Pigmentation                         |                                              3                           |             
      Pelvis, Transitional Epithelium,     |                                                                          |             
           Hyperplasia                     |                                           3                              |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Inflammation, Chronic                |                                           3                              |             
      Transitional Epithelium, Hyperplasia |                                           3                              |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  40                                                               
NTP Experiment-Test: 05089-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 16:21:47  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 6| 6| 7| 7| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 2| 9| 3| 3| 5| 5| 5| 5| 5|                                            |            |
                                           | 6| 8| 7| 2| 2| 7| 7| 8| 8| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |      A     |
    0.0100%                                | 6| 6| 6| 6| 6| 8| 8| 8| 8| 8|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +                                                            |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +                                                            |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +                                                            |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +                                                            |  50        |
      Parasite Metazoan                    |                                                                          |      3  1.3|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +                                                            |  50        |
      Parasite Metazoan                    |                                                                          |      3  1.3|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +                                                            |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +     +  +                                                            |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +     +  +                                                            |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +     +  +                                                            |  49        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +                                                            |  50        |
      Angiectasis                          |                                                                          |      3  2.0|
      Cyst                                 |                                                                          |      1  2.0|
      Fatty Change                         |       3                                                                  |     13  2.4|
      Focal Cellular Change                | 1        1  1                                                            |     32  1.6|
      Granuloma                            | 2  2     2  1                                                            |     36  1.4|
      Hematopoietic Cell Proliferation     |    1                                                                     |      3  1.7|
      Hepatodiaphragmatic Nodule           |                                                                          |      6  2.5|
      Hyperplasia, Multifocal              |       2                                                                  |      8  1.8|
      Infiltration Cellular, Mixed Cell    |                                                                          |      3  2.0|
      Necrosis, Focal                      |                                                                          |      1  2.0|
      Bile Duct, Hyperplasia               | 1     2     1                                                            |     35  1.4|
      Biliary Tract, Fibrosis              |       1     1                                                            |     26  1.3|
      Centrilobular, Atrophy               |       2                                                                  |      4  2.3|
      Centrilobular, Necrosis              |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |       +                                                                  |   5        |
      Inflammation, Chronic                |                                                                          |      3  2.7|
      Fat, Necrosis                        |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +                                                            |  49        |
      Atrophy, Focal                       |                                                                          |      7  1.4|
      Edema                                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +                                                            |  50        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +                                                            |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +                                                            |  50        |
      Cyst                                 |                                                                          |      1  1.0|
      Edema                                |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                                                          |      5  2.8|
      Perforation                          |                                                                          |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  41                                                               
NTP Experiment-Test: 05089-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 16:21:47  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 6| 6| 7| 7| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 2| 9| 3| 3| 5| 5| 5| 5| 5|                                            |            |
                                           | 6| 8| 7| 2| 2| 7| 7| 8| 8| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |      A     |
    0.0100%                                | 6| 6| 6| 6| 6| 8| 8| 8| 8| 8|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Ulcer                                |                                                                          |      3  3.7|
      Mucosa, Hyperplasia, Papillary       |                                                                          |      5  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +                                                            |  50        |
      Edema                                |                                                                          |      1  2.0|
      Erosion                              |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                                                          |      2  2.0|
      Mucosa, Hyperplasia                  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +                                                            |  50        |
      Thrombosis                           |                                                                          |      2  2.5|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +                                                            |  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +                                                            |  50        |
      Angiectasis                          | 2                                                                        |      1  2.0|
      Congestion                           |                                                                          |      1  2.0|
      Degeneration                         |                                                                          |      1  3.0|
      Fibrosis                             |                                                                          |      1  2.0|
      Focal Cellular Change                |                                                                          |     14  1.5|
      Vacuolization Cytoplasmic            |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +                                                            |  50        |
      Hyperplasia                          |                                                                          |      6  1.5|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +                                                            |  49        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +                                                            |  50        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +                                                            |  50        |
      Angiectasis                          |    1  3                                                                  |     36  2.2|
      Cyst                                 |          2                                                               |      4  2.5|
      Pars Distalis, Hyperplasia, Focal    |          1                                                               |      9  1.9|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +                                                            |  50        |
      C-Cell, Hyperplasia                  |          2                                                               |     11  1.3|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +                                                            |  50        |
      Degeneration, Cystic                 |                                                                          |      2  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  42                                                               
NTP Experiment-Test: 05089-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 16:21:47  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 6| 6| 7| 7| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 2| 9| 3| 3| 5| 5| 5| 5| 5|                                            |            |
                                           | 6| 8| 7| 2| 2| 7| 7| 8| 8| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |      A     |
    0.0100%                                | 6| 6| 6| 6| 6| 8| 8| 8| 8| 8|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia                          |          2                                                               |      6  2.0|
      Inflammation, Suppurative            |                                                                          |      9  1.9|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +                                                            |  50        |
      Follicle, Cyst                       |                                                                          |      1  3.0|
      Periovarian Tissue, Cyst             |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +                                                            |  50        |
      Decidual Reaction                    |                                                                          |      1  3.0|
      Hydrometra                           |                                                                          |      5  2.6|
      Inflammation, Suppurative            |                                                                          |      2  2.0|
      Endometrium, Hyperplasia, Cystic     |    2  2  1  1                                                            |     38  1.5|
                                            __________________________________________________________________________|____________|
   Vagina                                  |       +  +                                                               |  11        |
      Cyst                                 |       2  3                                                               |     10  2.5|
      Inflammation, Suppurative            |       3  3                                                               |      8  2.8|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +                                                            |  50        |
      Hypercellularity                     |                                                                          |      5  2.6|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +                                                            |  50        |
      Inguinal, Hyperplasia                | 3                                                                        |      3  2.7|
      Mediastinal, Angiectasis             | 2                                                                        |      7  2.3|
      Mediastinal, Hyperplasia             |                                                                          |      1  3.0|
      Pancreatic, Angiectasis              |                                                                          |      3  2.7|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +                                                            |  49        |
      Angiectasis                          |                                                                          |      3  2.0|
      Hyperplasia                          | 3                                                                        |      3  2.3|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +                                                            |  50        |
      Angiectasis                          |                                                                          |      3  2.7|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +                                                            |  50        |
      Depletion Cellular                   |                                                                          |      2  1.5|
      Developmental Malformation           |                                                                          |      1  2.0|
      Fibrosis                             |                                                                          |      1  3.0|
      Hematopoietic Cell Proliferation     |    2                                                                     |      7  3.0|
      Hyperplasia, Histiocytic, Lymphoid   |                                                                          |      2  2.5|
      Necrosis, Focal                      |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +                                                            |  49        |
      Cyst                                 |                                                                          |      2  2.0|
      Epithelial Cell, Hyperplasia         |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  43                                                               
NTP Experiment-Test: 05089-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 16:21:47  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 6| 6| 7| 7| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 2| 9| 3| 3| 5| 5| 5| 5| 5|                                            |            |
                                           | 6| 8| 7| 2| 2| 7| 7| 8| 8| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |      A     |
    0.0100%                                | 6| 6| 6| 6| 6| 8| 8| 8| 8| 8|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +                                                            |  50        |
      Dilatation                           |       2     2                                                            |     40  2.0|
      Fibrosis                             |                                                                          |      1  2.0|
      Hyperplasia                          |                                                                          |      5  2.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +                                                            |  50        |
      Erosion                              | 2                                                                        |      1  2.0|
      Exudate                              | 4                                                                        |      1  4.0|
      Hemorrhage                           |                                                                          |      1  2.0|
      Inflammation, Chronic                | 4                                                                        |      2  3.0|
      Ulcer                                |                                                                          |      1  2.0|
      Sebaceous Gland, Cyst                |                                                                          |      1  2.0|
      Subcutaneous Tissue, Foreign Body    | 2                                                                        |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +                                                            |  50        |
      Hyperostosis                         |          2                                                               |     11  1.8|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +                                                            |  49        |
      Compression                          |                                                                          |      5  2.2|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +                                                            |  50        |
      Congestion                           |                                                                          |      1  2.0|
      Hemorrhage                           |                                                                          |      1  2.0|
      Hyperplasia, Macrophage              |                                                                          |      2  1.5|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      4  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +                                                            |  50        |
      Fungus                               |             2                                                            |      3  1.7|
      Inflammation, Suppurative            |             2                                                            |      3  1.7|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +                                                            |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Eye                                     |       +     +                                                            |   5        |
      Cataract                             |       4                                                                  |      4  3.3|
      Hemorrhage                           |                                                                          |      1  3.0|
      Retina, Degeneration                 |       4                                                                  |      3  3.3|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  44                                                               
NTP Experiment-Test: 05089-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 16:21:47  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 6| 6| 7| 7| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 2| 9| 3| 3| 5| 5| 5| 5| 5|                                            |            |
                                           | 6| 8| 7| 2| 2| 7| 7| 8| 8| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |      A     |
    0.0100%                                | 6| 6| 6| 6| 6| 8| 8| 8| 8| 8|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +                                                            |  50        |
      Atrophy                              |             3                                                            |      1  3.0|
      Inflammation, Suppurative            |                                                                          |      1  3.0|
      Mineralization                       | 2                                                                        |      2  1.5|
      Nephropathy                          | 1  1  2  2  3                                                            |     50  2.0|
      Pigmentation                         |                                                                          |      1  3.0|
      Pelvis, Transitional Epithelium,     |                                                                          |            |
           Hyperplasia                     |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +                                                            |  50        |
      Hemorrhage                           |                                                                          |      1  3.0|
      Inflammation, Chronic                |                                                                          |      1  3.0|
      Transitional Epithelium, Hyperplasia |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  45                                                               
NTP Experiment-Test: 05089-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 16:21:47  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 2| 7| 7| 7| 7| 3| 7| 7| 7| 7|             
                             DAY ON TEST   | 5| 0| 3| 3| 3| 2| 4| 3| 3| 3| 2| 9| 3| 3| 3| 9| 1| 3| 3| 3| 4| 3| 3| 3| 3|             
                                           | 2| 3| 2| 2| 2| 6| 1| 2| 2| 2| 6| 5| 2| 2| 2| 9| 9| 0| 0| 0| 8| 2| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    0.00500%                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |       4                                                                  |             
      Necrosis                             |       4                                                                  |             
      Parasite Metazoan                    |                                                                          |             
      Perforation                          |       4                                                                  |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                1     2   |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                         3                                               2|             
      Congestion                           |                      2                                                   |             
      Fatty Change                         | 4  3  2           3  2     1  2  3     1  2  3  3  1  2                  |             
      Focal Cellular Change                |          2        2  2  2     2        1  2           2           1  2  2|             
      Granuloma                            |    2     1  1  1     2  1  1  3     1  1  1  3     2  2  1  1  1  2  1  1|             
      Hematopoietic Cell Proliferation     |          2                                                               |             
      Hepatodiaphragmatic Nodule           |                                                                          |             
      Hyperplasia, Histiocytic, Lymphoid   |                                                                          |             
      Hyperplasia, Multifocal              |                   2           2                 2                        |             
      Infiltration Cellular, Mixed Cell    |          2     2  2     2  2                                            2|             
      Necrosis, Focal                      |    2              2                                                      |             
      Bile Duct, Hyperplasia               |    1  1     1     1           1           1     2     1  1  1  1        1|             
      Biliary Tract, Fibrosis              |             1     1           1  2        1     2     1  1     1        1|             
      Centrilobular, Atrophy               | 2                 2              3              2                        |             
      Serosa, Fibrosis                     |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               | +     +                    +     +           +     +                     |             
      Accessory Spleen                     |                            2                                             |             
      Inflammation, Chronic                |       3                          2           2     2                     |             
      Fat, Necrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy, Focal                       |    1        1                    2                                      1|             
      Cytoplasmic Alteration               |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Basal Cell              | 2                                                                        |             
      Inflammation, Chronic                |                                              2     3                     |             
      Perforation                          |                                                    3                     |             
      Ulcer                                |                                                    3                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  46                                                               
NTP Experiment-Test: 05089-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 16:21:47  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 2| 7| 7| 7| 7| 3| 7| 7| 7| 7|             
                             DAY ON TEST   | 5| 0| 3| 3| 3| 2| 4| 3| 3| 3| 2| 9| 3| 3| 3| 9| 1| 3| 3| 3| 4| 3| 3| 3| 3|             
                                           | 2| 3| 2| 2| 2| 6| 1| 2| 2| 2| 6| 5| 2| 2| 2| 9| 9| 0| 0| 0| 8| 2| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    0.00500%                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Mucosa, Hyperplasia, Papillary       |                                                    3                     |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                    2                     |             
                                            __________________________________________________________________________|             
   Tongue                                  |    +                                                                     |             
      Hyperplasia, Squamous                |    2                                                                     |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                        +                                 |             
      Mesenteric Artery, Inflammation,     |                                                                          |             
           Chronic                         |                                        2                                 |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Artery, Inflammation, Chronic        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Congestion                           | 2                                                                        |             
      Focal Cellular Change                |          1  1     1  1     1              1           1     1  1         |             
      Necrosis                             |                                  2                                       |             
      Vacuolization Cytoplasmic            | 3                                3                                       |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Developmental Malformation           |                                                                          |             
      Hyperplasia                          |                         1              1        1                    1   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 3  2     2  2  1  3  3  4  3  3  3  3  3  2        3  3  3     2  2  2  3|             
      Cyst                                 |                                              1                           |             
      Hemorrhage                           |                                                                          |             
      Pars Distalis, Hyperplasia, Focal    |                                                 2        2           1   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |          1                                      1     1           1     2|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              | +     +                                                                  |             
      Abdominal, Hemorrhage                |       4                                                                  |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 |                                                                          |             
      Hyperplasia                          |                                        2        2                 2      |             
      Inflammation, Suppurative            |          3                    2        2        3                       4|             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  47                                                               
NTP Experiment-Test: 05089-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 16:21:47  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 2| 7| 7| 7| 7| 3| 7| 7| 7| 7|             
                             DAY ON TEST   | 5| 0| 3| 3| 3| 2| 4| 3| 3| 3| 2| 9| 3| 3| 3| 9| 1| 3| 3| 3| 4| 3| 3| 3| 3|             
                                           | 2| 3| 2| 2| 2| 6| 1| 2| 2| 2| 6| 5| 2| 2| 2| 9| 9| 0| 0| 0| 8| 2| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    0.00500%                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Corpus Luteum, Thecal Cell,          |                                                                          |             
          Hyperplasia                      |                                                                          |             
      Periovarian Tissue, Cyst             |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydrometra                           |                                                                          |             
      Endometrium, Hyperplasia, Cystic     |       2  1  1  2  1  2  1  1  1     2  1        2  2           2  1  1  1|             
                                            __________________________________________________________________________|             
   Vagina                                  |                +  +                    +                                 |             
      Cyst                                 |                3  3                    2                                 |             
      Inflammation, Suppurative            |                3  3                                                      |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hypercellularity                     |    2     3        3                       2                              |             
      Myelofibrosis                        |                                                 2                        |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mediastinal, Angiectasis             |                   3                                         3            |             
      Pancreatic, Hyperplasia, Histiocytic |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |       2                                                                  |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Depletion Cellular                   |       2                                                                  |             
      Fibrosis                             |                                  2                                       |             
      Hematopoietic Cell Proliferation     |    3  2  3        2  2     2                                             |             
      Hyperplasia, Histiocytic, Lymphoid   |                      2                    4                              |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                      1                                1              2   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           | 2  2  2  2  1     2  2  2  2  4  2  2  3           4  2  2     2  2  2  2|             
      Hyperplasia                          |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Epidermis, Hyperplasia               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  48                                                               
NTP Experiment-Test: 05089-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 16:21:47  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 6| 6| 7| 7| 7| 6| 6| 7| 7| 7| 2| 7| 7| 7| 7| 3| 7| 7| 7| 7|             
                             DAY ON TEST   | 5| 0| 3| 3| 3| 2| 4| 3| 3| 3| 2| 9| 3| 3| 3| 9| 1| 3| 3| 3| 4| 3| 3| 3| 3|             
                                           | 2| 3| 2| 2| 2| 6| 1| 2| 2| 2| 6| 5| 2| 2| 2| 9| 9| 0| 0| 0| 8| 2| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    0.00500%                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
      Hyperostosis                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                         2  2  2        3           3  2        3        2|             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                              2                           |             
      Hemorrhage                           |    2                                                                     |             
      Hyperplasia, Macrophage              |                   2                                                      |             
      Inflammation, Acute                  |                      1                                                   |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fungus                               |          2        2                                                      |             
      Inflammation, Suppurative            |          2  1     2                                                      |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     | +                                                                        |             
      Cornea, Inflammation, Acute          | 2                                                                        |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                   3                                                      |             
      Inflammation, Suppurative            |                   2                                                      |             
      Mineralization                       |                                              1                           |             
      Nephropathy                          | 1  1  2  1  1  1  4  3  3  3  2  3  1  3  2     2  3  2  1  1  4  3  3  3|             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Transitional Epithelium, Hyperplasia |                                              1                           |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  49                                                               
NTP Experiment-Test: 05089-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 16:21:47  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 5| 5| 6| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 5| 5| 5| 5| 5| 7| 7| 9| 1| 3| 2| 0| 3| 3| 3| 5| 1| 1| 3| 3| 5| 3| 3| 3| 3|             
                                           | 7| 7| 8| 9| 9| 0| 6| 8| 9| 0| 2| 2| 1| 1| 1| 2| 4| 9| 1| 1| 6| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0.00500%                               | 7| 7| 7| 7| 7| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Necrosis                             |                                                                          |             
      Parasite Metazoan                    |                               1                       2                  |             
      Perforation                          |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                           2                              |             
                                            __________________________________________________________________________|             
   Intestine Small                         |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |                +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Congestion                           |                                                                          |             
      Fatty Change                         |                   2                             4        1               |             
      Focal Cellular Change                |                1  2  1  1  2  1  2  1  2  2  1     2  2  1  2  2  2  2  2|             
      Granuloma                            |                1  1        1  2  1  2     2        2  2  1  1  2  1  2  1|             
      Hematopoietic Cell Proliferation     |                                              2                           |             
      Hepatodiaphragmatic Nodule           |                3           3                          3           3      |             
      Hyperplasia, Histiocytic, Lymphoid   |                                        2                                 |             
      Hyperplasia, Multifocal              |                      2                          2                        |             
      Infiltration Cellular, Mixed Cell    |                         2                    4     2     2               |             
      Necrosis, Focal                      |                                                 1                        |             
      Bile Duct, Hyperplasia               |                   1  1  1  1  1  1  1  2  2     1  1  1  1  1  1  1  1  1|             
      Biliary Tract, Fibrosis              |                   1     1  1  1  1     2  1     1     1  1  1  1  1  1  1|             
      Centrilobular, Atrophy               |                      2                          3                        |             
      Serosa, Fibrosis                     |                                  2                                       |             
                                            __________________________________________________________________________|             
   Mesentery                               |                      +           +        +              +  +            |             
      Accessory Spleen                     |                                                                          |             
      Inflammation, Chronic                |                                                          2  2            |             
      Fat, Necrosis                        |                                  2        2                              |             
                                            __________________________________________________________________________|             
   Pancreas                                |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy, Focal                       |                         1                       1                        |             
      Cytoplasmic Alteration               |                                                                1         |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Basal Cell              |                                                                          |             
      Inflammation, Chronic                |                                                          3               |             
      Perforation                          |                                                                          |             
      Ulcer                                |                                                          4               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  50                                                               
NTP Experiment-Test: 05089-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 16:21:47  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 5| 5| 6| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 5| 5| 5| 5| 5| 7| 7| 9| 1| 3| 2| 0| 3| 3| 3| 5| 1| 1| 3| 3| 5| 3| 3| 3| 3|             
                                           | 7| 7| 8| 9| 9| 0| 6| 8| 9| 0| 2| 2| 1| 1| 1| 2| 4| 9| 1| 1| 6| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0.00500%                               | 7| 7| 7| 7| 7| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Mucosa, Hyperplasia, Papillary       |                                                          3               |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
      Hyperplasia, Squamous                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
      Mesenteric Artery, Inflammation,     |                                                                          |             
           Chronic                         |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Artery, Inflammation, Chronic        |                            2                                             |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                      2                       3                           |             
      Congestion                           |                                                                          |             
      Focal Cellular Change                |                                                    2     2        1      |             
      Necrosis                             |                                                                          |             
      Vacuolization Cytoplasmic            |                                                 3                        |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Developmental Malformation           |                                              1                           |             
      Hyperplasia                          |                                                    1     1               |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |                +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |                +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                4  3  3  3  1     3  3     2     2  2  2  3  2     1      |             
      Cyst                                 |                                                                          |             
      Hemorrhage                           |                      4                                                   |             
      Pars Distalis, Hyperplasia, Focal    |                                           3                       2     3|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |                                              2  1                        |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
      Abdominal, Hemorrhage                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 |                                                                          |             
      Hyperplasia                          |                         2                                                |             
      Inflammation, Suppurative            |                2           1                                             |             
                                            __________________________________________________________________________|             
   Ovary                                   |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  51                                                               
NTP Experiment-Test: 05089-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 16:21:47  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 5| 5| 6| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 5| 5| 5| 5| 5| 7| 7| 9| 1| 3| 2| 0| 3| 3| 3| 5| 1| 1| 3| 3| 5| 3| 3| 3| 3|             
                                           | 7| 7| 8| 9| 9| 0| 6| 8| 9| 0| 2| 2| 1| 1| 1| 2| 4| 9| 1| 1| 6| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0.00500%                               | 7| 7| 7| 7| 7| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Corpus Luteum, Thecal Cell,          |                                                                          |             
          Hyperplasia                      |                                                                   3      |             
      Periovarian Tissue, Cyst             |                                                       2                  |             
                                            __________________________________________________________________________|             
   Uterus                                  |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hydrometra                           |                      3                                                   |             
      Endometrium, Hyperplasia, Cystic     |                   1  2     2     2  1  2  2  2  2  1  2  2               |             
                                            __________________________________________________________________________|             
   Vagina                                  |                +              +        +                             +   |             
      Cyst                                 |                3                       1                             4   |             
      Inflammation, Suppurative            |                2                                                     3   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hypercellularity                     |                   2                          3           3               |             
      Myelofibrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mediastinal, Angiectasis             |                   2                                                      |             
      Pancreatic, Hyperplasia, Histiocytic |                                                       2                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |                M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                2         |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                      2   |             
      Hyperplasia                          |                                                             2            |             
                                            __________________________________________________________________________|             
   Spleen                                  |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Depletion Cellular                   |                                                                          |             
      Fibrosis                             |                                                                          |             
      Hematopoietic Cell Proliferation     |                                              2                           |             
      Hyperplasia, Histiocytic, Lymphoid   |                                     1                                    |             
                                            __________________________________________________________________________|             
   Thymus                                  |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                2  2  2  1  2     1  2     2  2  2  2  1  2  3  1  3  2  2|             
      Hyperplasia                          |                                        2     2              3            |             
      Inflammation, Suppurative            |                                                             3            |             
                                            __________________________________________________________________________|             
   Skin                                    |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Epidermis, Hyperplasia               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  52                                                               
NTP Experiment-Test: 05089-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 16:21:47  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 5| 5| 6| 7| 7| 6| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 5| 5| 5| 5| 5| 7| 7| 9| 1| 3| 2| 0| 3| 3| 3| 5| 1| 1| 3| 3| 5| 3| 3| 3| 3|             
                                           | 7| 7| 8| 9| 9| 0| 6| 8| 9| 0| 2| 2| 1| 1| 1| 2| 4| 9| 1| 1| 6| 1| 1| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0.00500%                               | 7| 7| 7| 7| 7| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
      Hyperostosis                         |                   2                                   3              2   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                4        2        3                 2     2  2            |             
      Hemorrhage                           |                4                                3                        |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                             4        2   |             
      Hemorrhage                           |                3                                2                        |             
      Hyperplasia, Macrophage              |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fungus                               |                   2  1                             2              3     2|             
      Inflammation, Suppurative            |                   2  1                             2              3     2|             
                                            __________________________________________________________________________|             
   Trachea                                 |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                      +                                                   |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Cornea, Inflammation, Acute          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Mineralization                       |                                              1                           |             
      Nephropathy                          |                2  2  2  3  2  2  3  3  2  1  1  2  2  3  4  2  3  2  2  2|             
      Pigmentation                         |                                              2                           |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Transitional Epithelium, Hyperplasia |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  53                                                               
NTP Experiment-Test: 05089-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 16:21:47  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 7| 7| 7| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 4| 6| 2| 3| 3| 5| 5| 5| 5| 5|                                            |            |
                                           | 0| 2| 6| 0| 1| 7| 7| 8| 8| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|                                            |      A     |
    0.00500%                               | 3| 3| 3| 3| 3| 5| 5| 5| 5| 5|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +                                                            |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +                                                            |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +                                                            |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +                                                            |  50        |
      Inflammation, Chronic                |                                                                          |      1  4.0|
      Necrosis                             |                                                                          |      1  4.0|
      Parasite Metazoan                    |                                                                          |      2  1.5|
      Perforation                          |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +                                                            |  50        |
      Parasite Metazoan                    |          1                                                               |      4  1.5|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +                                                            |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +                                                            |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +                                                            |  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +                                                            |  50        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +                                                            |  50        |
      Angiectasis                          |                                                                          |      2  2.5|
      Congestion                           |                                                                          |      1  2.0|
      Fatty Change                         |                                                                          |     17  2.3|
      Focal Cellular Change                | 1  1  1  1  1                                                            |     35  1.6|
      Granuloma                            |       2  2  2                                                            |     38  1.5|
      Hematopoietic Cell Proliferation     |                                                                          |      2  2.0|
      Hepatodiaphragmatic Nodule           |             2                                                            |      5  2.8|
      Hyperplasia, Histiocytic, Lymphoid   |                                                                          |      1  2.0|
      Hyperplasia, Multifocal              | 1                                                                        |      6  1.8|
      Infiltration Cellular, Mixed Cell    |             2                                                            |     11  2.2|
      Necrosis, Focal                      |                                                                          |      3  1.7|
      Bile Duct, Hyperplasia               | 1     1                                                                  |     32  1.1|
      Biliary Tract, Fibrosis              | 1     1                                                                  |     27  1.1|
      Centrilobular, Atrophy               | 2                                                                        |      7  2.3|
      Serosa, Fibrosis                     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |  11        |
      Accessory Spleen                     |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                                                          |      6  2.2|
      Fat, Necrosis                        |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +                                                            |  50        |
      Atrophy, Focal                       |                                                                          |      6  1.2|
      Cytoplasmic Alteration               |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +                                                            |  50        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +                                                            |  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  54                                                               
NTP Experiment-Test: 05089-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 16:21:47  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 7| 7| 7| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 4| 6| 2| 3| 3| 5| 5| 5| 5| 5|                                            |            |
                                           | 0| 2| 6| 0| 1| 7| 7| 8| 8| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|                                            |      A     |
    0.00500%                               | 3| 3| 3| 3| 3| 5| 5| 5| 5| 5|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +                                                            |  50        |
      Hyperplasia, Basal Cell              |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                                                          |      3  2.7|
      Perforation                          |                                                                          |      1  3.0|
      Ulcer                                |                                                                          |      2  3.5|
      Mucosa, Hyperplasia, Papillary       |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +                                                            |  50        |
      Inflammation, Chronic                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
      Hyperplasia, Squamous                |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   1        |
      Mesenteric Artery, Inflammation,     |                                                                          |            |
           Chronic                         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +                                                            |  50        |
      Artery, Inflammation, Chronic        |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +                                                            |  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +                                                            |  50        |
      Angiectasis                          |                                                                          |      2  2.5|
      Congestion                           | 2                                                                        |      2  2.0|
      Focal Cellular Change                |          1  1                                                            |     14  1.1|
      Necrosis                             |                                                                          |      1  2.0|
      Vacuolization Cytoplasmic            |                                                                          |      3  3.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +                                                            |  49        |
      Developmental Malformation           |                                                                          |      1  1.0|
      Hyperplasia                          |                                                                          |      6  1.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +                                                            |  50        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +                                                            |  47        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +                                                            |  49        |
      Angiectasis                          | 2  4  1  1  3                                                            |     40  2.5|
      Cyst                                 |                                                                          |      1  1.0|
      Hemorrhage                           |                                                                          |      1  4.0|
      Pars Distalis, Hyperplasia, Focal    |                                                                          |      6  2.2|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +                                                            |  50        |
      C-Cell, Hyperplasia                  |          2                                                               |      8  1.4|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  55                                                               
NTP Experiment-Test: 05089-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 16:21:47  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 7| 7| 7| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 4| 6| 2| 3| 3| 5| 5| 5| 5| 5|                                            |            |
                                           | 0| 2| 6| 0| 1| 7| 7| 8| 8| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|                                            |      A     |
    0.00500%                               | 3| 3| 3| 3| 3| 5| 5| 5| 5| 5|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENERAL BODY SYSTEM - cont                |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   2        |
      Abdominal, Hemorrhage                |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +                                                            |  50        |
      Degeneration, Cystic                 |          2                                                               |      1  2.0|
      Hyperplasia                          |                                                                          |      4  2.0|
      Inflammation, Suppurative            |       3                                                                  |      8  2.5|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +                                                            |  50        |
      Corpus Luteum, Thecal Cell,          |                                                                          |            |
          Hyperplasia                      |                                                                          |      1  3.0|
      Periovarian Tissue, Cyst             |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +                                                            |  50        |
      Hydrometra                           |                                                                          |      1  3.0|
      Endometrium, Hyperplasia, Cystic     |    1     2  2                                                            |     32  1.6|
                                            __________________________________________________________________________|____________|
   Vagina                                  |                                                                          |   7        |
      Cyst                                 |                                                                          |      6  2.7|
      Inflammation, Suppurative            |                                                                          |      4  2.8|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +                                                            |  50        |
      Hypercellularity                     |                                                                          |      7  2.6|
      Myelofibrosis                        |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +                                                            |  50        |
      Mediastinal, Angiectasis             |                                                                          |      3  2.7|
      Pancreatic, Hyperplasia, Histiocytic |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +                                                            |  49        |
      Angiectasis                          |                                                                          |      1  2.0|
      Hyperplasia                          |       2                                                                  |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +                                                            |  50        |
      Angiectasis                          |                                                                          |      1  2.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +                                                            |  50        |
      Depletion Cellular                   |                                                                          |      1  2.0|
      Fibrosis                             |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     |          2                                                               |      8  2.3|
      Hyperplasia, Histiocytic, Lymphoid   |             1                                                            |      4  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  56                                                               
NTP Experiment-Test: 05089-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 16:21:47  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 7| 7| 7| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 4| 6| 2| 3| 3| 5| 5| 5| 5| 5|                                            |            |
                                           | 0| 2| 6| 0| 1| 7| 7| 8| 8| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|                                            |      A     |
    0.00500%                               | 3| 3| 3| 3| 3| 5| 5| 5| 5| 5|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +                                                            |  47        |
      Cyst                                 |                                                                          |      3  1.3|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +                                                            |  50        |
      Dilatation                           | 2  2  2  2  2                                                            |     43  2.0|
      Hyperplasia                          |                                                                          |      3  2.3|
      Inflammation, Suppurative            |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +                                                            |  50        |
      Hyperkeratosis                       |       2                                                                  |      1  2.0|
      Inflammation, Chronic                |       2                                                                  |      1  2.0|
      Epidermis, Hyperplasia               |       2                                                                  |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +                                                            |  50        |
      Hyperostosis                         | 1        2  2                                                            |      6  2.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +                                                            |  50        |
      Compression                          |    4        3                                                            |     16  2.6|
      Hemorrhage                           |                                                                          |      2  3.5|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +                                                            |  50        |
      Congestion                           |                                                                          |      3  2.7|
      Hemorrhage                           |                                                                          |      3  2.3|
      Hyperplasia, Macrophage              |                                                                          |      1  2.0|
      Inflammation, Acute                  |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +                                                            |  50        |
      Fungus                               |                                                                          |      7  2.0|
      Inflammation, Suppurative            |                                                                          |      8  1.9|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +                                                            |  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
      Cornea, Inflammation, Acute          |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  57                                                               
NTP Experiment-Test: 05089-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 16:21:47  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 6| 7| 7| 7| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 4| 6| 2| 3| 3| 5| 5| 5| 5| 5|                                            |            |
                                           | 0| 2| 6| 0| 1| 7| 7| 8| 8| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|                                            |      A     |
    0.00500%                               | 3| 3| 3| 3| 3| 5| 5| 5| 5| 5|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +                                                            |  50        |
      Fibrosis                             |                                                                          |      1  3.0|
      Inflammation, Suppurative            |                                                                          |      1  2.0|
      Mineralization                       |                                                                          |      2  1.0|
      Nephropathy                          |    1  1  2  3                                                            |     48  2.2|
      Pigmentation                         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +                                                            |  50        |
      Transitional Epithelium, Hyperplasia |                                                                          |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  58                                                               
NTP Experiment-Test: 05089-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 16:21:47  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| 6| 6| 7| 7|             
                             DAY ON TEST   | 8| 1| 2| 2| 2| 2| 2| 2| 2| 2| 1| 3| 3| 3| 3| 5| 1| 2| 2| 2| 3| 0| 6| 2| 2|             
                                           | 3| 0| 9| 9| 9| 9| 9| 9| 9| 9| 8| 0| 0| 0| 0| 4| 8| 9| 9| 9| 0| 5| 8| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0.0275%                                | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                 2                        |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Atrophy, Focal                       |                                                                          |             
      Fatty Change                         |    4                          3                 2           1  2         |             
      Focal Cellular Change                | 1        1  2  2  1  1  2  2     1  1  2  2           1  2  1     2  2  1|             
      Granuloma                            |    1        2     1  2  2  2     1     2  1        1  1  1     2  3  2  2|             
      Hematopoietic Cell Proliferation     |                                                             2            |             
      Hepatodiaphragmatic Nodule           | 3  3           3                             2                          2|             
      Hyperplasia, Multifocal              |                               2              2  2                       2|             
      Infiltration Cellular, Mixed Cell    |                2     2                                      2            |             
      Inflammation, Focal                  | 2                                                                        |             
      Bile Duct, Hyperplasia               |       1  1     1  1  1  2  2  1     1        2  3  1  1  1     1  1  2  2|             
      Biliary Tract, Fibrosis              |                         1  1  1     1        1  2     1        1  1  2  1|             
      Centrilobular, Atrophy               |                               3              2  3                        |             
                                            __________________________________________________________________________|             
   Mesentery                               |    +                          +              +                 +         |             
      Hemorrhage                           |                                                                2         |             
      Inflammation, Chronic                |    3                                                           2         |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy, Focal                       |       1        1                             2                           |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Focal Cellular Change                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |    3                                                                     |             
      Ulcer                                |    3                                                                     |             
      Mucosa, Hyperplasia, Papillary       |    4                          2                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |    1                                                                     |             
      Mucosa, Cyst                         |                            1                                             |             
                                            __________________________________________________________________________|             
   Tooth                                   | +                                                                        |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  59                                                               
NTP Experiment-Test: 05089-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 16:21:47  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| 6| 6| 7| 7|             
                             DAY ON TEST   | 8| 1| 2| 2| 2| 2| 2| 2| 2| 2| 1| 3| 3| 3| 3| 5| 1| 2| 2| 2| 3| 0| 6| 2| 2|             
                                           | 3| 0| 9| 9| 9| 9| 9| 9| 9| 9| 8| 0| 0| 0| 0| 4| 8| 9| 9| 9| 0| 5| 8| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0.0275%                                | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                +         |             
      Mesenteric Artery, Inflammation,     |                                                                          |             
           Chronic                         |                                                                4         |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                                                          |             
      Thrombosis                           |                                                                          |             
      Pericardium, Edema                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                                                                          |             
      Angiectasis                          | 2                                                                        |             
      Congestion                           |                                              2  2                        |             
      Focal Cellular Change                |    1        2  2  1  2  1                                               2|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 2                                                                        |             
      Hematopoietic Cell Proliferation     |                                                                1         |             
      Hyperplasia                          |       2                                                                  |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 2  2  2  2  2  1           2     4  3  2  1     3  3  3  1     2  2  3  2|             
      Atrophy                              |                      1                                                   |             
      Cyst                                 |                                              2              2            |             
      Pars Distalis, Focal Cellular Change |                                                                          |             
      Pars Distalis, Hyperplasia, Focal    |       2           2  2                    2                              |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 |          1                                                               |             
      C-Cell, Hyperplasia                  | 1     2              2  1     1  1                    2                  |             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 |                                     3                                    |             
      Hyperplasia                          |    2                                               1                 2   |             
      Inflammation, Suppurative            |    2                                                                     |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  60                                                               
NTP Experiment-Test: 05089-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 16:21:47  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| 6| 6| 7| 7|             
                             DAY ON TEST   | 8| 1| 2| 2| 2| 2| 2| 2| 2| 2| 1| 3| 3| 3| 3| 5| 1| 2| 2| 2| 3| 0| 6| 2| 2|             
                                           | 3| 0| 9| 9| 9| 9| 9| 9| 9| 9| 8| 0| 0| 0| 0| 4| 8| 9| 9| 9| 0| 5| 8| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0.0275%                                | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Follicle, Cyst                       |       4           2                          4        4                  |             
      Periovarian Tissue, Cyst             |                                        2                                 |             
                                            __________________________________________________________________________|             
   Oviduct                                 |                                                                          |             
      Dilatation                           |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                2         |             
      Hemorrhage                           |                                                                          |             
      Hydrometra                           | 2                                                                        |             
      Intussusception                      |                                                                          |             
      Endometrium, Hyperplasia, Cystic     | 2           2     1           2  1     1           2  1  1               |             
                                            __________________________________________________________________________|             
   Vagina                                  |    +                    +                    +                           |             
      Cyst                                 |                         2                    X                           |             
      Exudate, Mucous                      |                                                                          |             
      Inflammation, Suppurative            |                         2                                                |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hypercellularity                     |                                                             3     3      |             
      Myelofibrosis                        | 1                                                                        |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inguinal, Inflammation, Suppurative  |                                              2                           |             
      Mediastinal, Angiectasis             |                                                 3  2           3         |             
      Mediastinal, Hyperplasia, Histiocytic|                                                                          |             
      Mediastinal, Hyperplasia, Lymphoid   | 2                                                                        |             
      Mediastinal, Hyperplasia             |                                                                          |             
      Pancreatic, Angiectasis              |                                                                          |             
      Pancreatic, Hyperplasia, Lymphoid    |                                                                          |             
      Pancreatic, Hyperplasia              |                                                                          |             
      Renal, Angiectasis                   |                                                                2         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Hyperplasia                          | 2                                                                        |             
      Inflammation, Suppurative            |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Angiectasis                          |    2                                2                                    |             
      Hyperplasia, Histiocytic             | 2                                                                        |             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |       3                                                        3         |             
      Hematopoietic Cell Proliferation     |       2                                                     3  4  4      |             
      Hemorrhage                           |                                                                3         |             
      Hyperplasia, Histiocytic, Lymphoid   |    2                       2        4                                    |             
      Necrosis, Focal                      |                                                                3         |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  61                                                               
NTP Experiment-Test: 05089-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 16:21:47  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| 6| 6| 7| 7|             
                             DAY ON TEST   | 8| 1| 2| 2| 2| 2| 2| 2| 2| 2| 1| 3| 3| 3| 3| 5| 1| 2| 2| 2| 3| 0| 6| 2| 2|             
                                           | 3| 0| 9| 9| 9| 9| 9| 9| 9| 9| 8| 0| 0| 0| 0| 4| 8| 9| 9| 9| 0| 5| 8| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0.0275%                                | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Inflammation, Suppurative            |                                                                3         |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |    2  1     2  2  2  1  1  1  2  2  2  2  2  2  2     2  1  2     2     2|             
      Hyperplasia                          |                                           2                    2     2   |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                              2                           |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperostosis                         |                                                 4                        |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |    3                             3              3                 2  2  1|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Macrophage              |                                                                          |             
      Inflammation, Chronic, Focal         |                                                                          |             
      Pigmentation                         |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                                                         2|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fungus                               |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Respiratory Epithelium, Degeneration,|                                                                          |             
           Mucoid                          |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                        +     M                           |             
      Cataract                             |                                                                          |             
      Cornea, Inflammation, Chronic        |                                                                          |             
      Retina, Degeneration                 |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +                                                                        |             
      Hyperplasia, Lymphoid                | 1                                                                        |             
      Acinus, Dilatation                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  62                                                               
NTP Experiment-Test: 05089-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 16:21:47  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 7| 5| 6| 6| 7| 7|             
                             DAY ON TEST   | 8| 1| 2| 2| 2| 2| 2| 2| 2| 2| 1| 3| 3| 3| 3| 5| 1| 2| 2| 2| 3| 0| 6| 2| 2|             
                                           | 3| 0| 9| 9| 9| 9| 9| 9| 9| 9| 8| 0| 0| 0| 0| 4| 8| 9| 9| 9| 0| 5| 8| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0.0275%                                | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Mineralization                       | 2                                                                        |             
      Nephropathy                          |    3  4  2  2  1  3  2  3  2  1  3  2  2  3  1  2  2  2  2  1  1  1  2  2|             
      Pelvis, Transitional Epithelium,     |                                                                          |             
           Hyperplasia                     |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Transitional Epithelium, Hyperplasia |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  63                                                               
NTP Experiment-Test: 05089-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 16:21:47  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7|             
                             DAY ON TEST   | 5| 5| 5| 5| 5| 3| 6| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 9| 1| 3| 3|             
                                           | 7| 8| 8| 9| 9| 8| 6| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 4| 8| 9| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0.0275%                                | 4| 4| 4| 4| 4| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                      1                          1        2               |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                               1                                          |             
      Atrophy, Focal                       |                                     2                                    |             
      Fatty Change                         |                2                                                  3      |             
      Focal Cellular Change                |    1        1        2  2  2  2  1     2  2  1     1  2  3     2     2  2|             
      Granuloma                            | 1  2  2  1  1     1  2  2  1  2     2        2     2  2        1     2  2|             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hepatodiaphragmatic Nodule           | 3        3        3     2                          2           3  3      |             
      Hyperplasia, Multifocal              |                2                 2     2        2        2  2     2      |             
      Infiltration Cellular, Mixed Cell    |                      2     2                                   2         |             
      Inflammation, Focal                  |                                                                          |             
      Bile Duct, Hyperplasia               |    1        2  2  1  2  1     2  2  2  2  1     2  2  1  3  2  1  2  1  2|             
      Biliary Tract, Fibrosis              |             1  1  1  2        2  1  2  2  1     2  1     2  2  1  2  1  1|             
      Centrilobular, Atrophy               |                2                 2     2        2        2  2     2      |             
                                            __________________________________________________________________________|             
   Mesentery                               |                +                       +        +        +  +     +      |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy, Focal                       |                                  2              1     1  1               |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                   2      |             
      Focal Cellular Change                |                                                                   1      |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Ulcer                                |                                                                          |             
      Mucosa, Hyperplasia, Papillary       |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Mucosa, Cyst                         |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  64                                                               
NTP Experiment-Test: 05089-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 16:21:47  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7|             
                             DAY ON TEST   | 5| 5| 5| 5| 5| 3| 6| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 9| 1| 3| 3|             
                                           | 7| 8| 8| 9| 9| 8| 6| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 4| 8| 9| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0.0275%                                | 4| 4| 4| 4| 4| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
      Mesenteric Artery, Inflammation,     |                                                                          |             
           Chronic                         |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                                                          |             
      Thrombosis                           |                                                                          |             
      Pericardium, Edema                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                                                          2               |             
      Angiectasis                          |          2                                                               |             
      Congestion                           |                                                                          |             
      Focal Cellular Change                |                2     2     1                 2                 2     3   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia                          |                                                             1            |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 2  1  2  2     3  3  1  2  3  2  2  3  2  4  2  2        4  2  2  3  4   |             
      Atrophy                              |                                                                          |             
      Cyst                                 |                                        2           1  3     1            |             
      Pars Distalis, Focal Cellular Change |    1  2                                                                  |             
      Pars Distalis, Hyperplasia, Focal    |          1           2              2        3                           |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 |                                                                          |             
      C-Cell, Hyperplasia                  | 1  1  1  1  1  2           2           2              1              1   |             
      Follicular Cell, Hyperplasia         |                                  2                                       |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 |                                                                          |             
      Hyperplasia                          |                            2  3           2                              |             
      Inflammation, Suppurative            |                            3  3           2                              |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  65                                                               
NTP Experiment-Test: 05089-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 16:21:47  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7|             
                             DAY ON TEST   | 5| 5| 5| 5| 5| 3| 6| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 9| 1| 3| 3|             
                                           | 7| 8| 8| 9| 9| 8| 6| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 4| 8| 9| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0.0275%                                | 4| 4| 4| 4| 4| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Follicle, Cyst                       |                         1                                4               |             
      Periovarian Tissue, Cyst             |                                                                          |             
                                            __________________________________________________________________________|             
   Oviduct                                 |                                                             +            |             
      Dilatation                           |                                                             3            |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hemorrhage                           |                                  3                             3         |             
      Hydrometra                           |                                                                          |             
      Intussusception                      |                   3                                                      |             
      Endometrium, Hyperplasia, Cystic     |                2     2  2  2  2  1  2  2     2     2  2  1  2     2      |             
                                            __________________________________________________________________________|             
   Vagina                                  |                +                 +           +     +  +                 +|             
      Cyst                                 |                1                                   3  3                 4|             
      Exudate, Mucous                      |                                  2                                       |             
      Inflammation, Suppurative            |                                                                         2|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hypercellularity                     |                   3  3                                                   |             
      Myelofibrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inguinal, Inflammation, Suppurative  |                                                                          |             
      Mediastinal, Angiectasis             | 1     1  1           3                             2                     |             
      Mediastinal, Hyperplasia, Histiocytic|                                                          3               |             
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |             
      Mediastinal, Hyperplasia             |                         2                                                |             
      Pancreatic, Angiectasis              |          2                                                               |             
      Pancreatic, Hyperplasia, Lymphoid    |                               3                                          |             
      Pancreatic, Hyperplasia              |                                     2                                    |             
      Renal, Angiectasis                   |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Inflammation, Suppurative            |                                                             2            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                         2|             
      Hyperplasia, Histiocytic             |                                                                          |             
      Hyperplasia, Lymphoid                |                               2                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
      Hematopoietic Cell Proliferation     |                      3                                                   |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Histiocytic, Lymphoid   |                      2              1        4                    2  3   |             
      Necrosis, Focal                      |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                               2                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  66                                                               
NTP Experiment-Test: 05089-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 16:21:47  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7|             
                             DAY ON TEST   | 5| 5| 5| 5| 5| 3| 6| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 9| 1| 3| 3|             
                                           | 7| 8| 8| 9| 9| 8| 6| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 4| 8| 9| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0.0275%                                | 4| 4| 4| 4| 4| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                     2                                    |             
      Inflammation, Suppurative            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                2  3     1  2  2  2  1  2  2  2  2  2     2  2  1  2  2  1|             
      Hyperplasia                          |                2  2        2              2                              |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                2                                                         |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperostosis                         |                                        3              2                  |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                   4                                                  3   |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Macrophage              |                2                                                         |             
      Inflammation, Chronic, Focal         |                                              1                           |             
      Pigmentation                         |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                               2                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fungus                               |                         2                                   2            |             
      Inflammation, Suppurative            |                         2                                   2            |             
      Respiratory Epithelium, Degeneration,|                                                                          |             
           Mucoid                          |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                     +                                    |             
      Cataract                             |                                     2                                    |             
      Cornea, Inflammation, Chronic        |                                     2                                    |             
      Retina, Degeneration                 |                                     3                                    |             
                                            __________________________________________________________________________|             
   Harderian Gland                         | +  +        +                                                            |             
      Hyperplasia, Lymphoid                |    2        2                                                            |             
      Acinus, Dilatation                   | 2                                                                        |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                   2      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  67                                                               
NTP Experiment-Test: 05089-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 16:21:47  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 6| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 6| 7| 7| 7|             
                             DAY ON TEST   | 5| 5| 5| 5| 5| 3| 6| 6| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 9| 1| 3| 3|             
                                           | 7| 8| 8| 9| 9| 8| 6| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 4| 8| 9| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0.0275%                                | 4| 4| 4| 4| 4| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Inflammation, Suppurative            |                                                                   2      |             
      Mineralization                       | 2  2  2  2  2                                                            |             
      Nephropathy                          | 2  2  1  1  2  1  2  1  1  3  1  2  3  3  2  3  1  2  2  3  2  3  3  3  2|             
      Pelvis, Transitional Epithelium,     |                                                                          |             
           Hyperplasia                     |                                                                   2      |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Transitional Epithelium, Hyperplasia |                                                       2                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  68                                                               
NTP Experiment-Test: 05089-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 16:21:47  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 0| 3| 3| 3| 3| 5| 5| 5| 5| 5|                                            |            |
                                           | 9| 0| 0| 0| 0| 7| 7| 8| 8| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |      A     |
    0.0275%                                | 0| 0| 0| 0| 0| 2| 2| 2| 2| 2|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Parasite Metazoan                    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Parasite Metazoan                    |                   1                                                      |      4  1.3|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Parasite Metazoan                    |    1              1  2                                                   |      3  1.3|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Angiectasis                          |                                                                          |      1  1.0|
      Atrophy, Focal                       |                                                                          |      1  2.0|
      Fatty Change                         | 2     2                                                                  |      9  2.3|
      Focal Cellular Change                |    2  1     2  1  1  1  1                                                |     41  1.6|
      Granuloma                            |    2  1     2  2  1  1  2  1                                             |     41  1.6|
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
      Hepatodiaphragmatic Nodule           |    2  3           2     2                                                |     16  2.6|
      Hyperplasia, Multifocal              | 2     2  2                                                               |     14  2.0|
      Infiltration Cellular, Mixed Cell    |                                                                          |      6  2.0|
      Inflammation, Focal                  |                                                                          |      1  2.0|
      Bile Duct, Hyperplasia               | 2  1  1  2  2  1     1  1  1                                             |     47  1.5|
      Biliary Tract, Fibrosis              | 1  1  1  1  2           1                                                |     34  1.3|
      Centrilobular, Atrophy               | 3        2                                                               |     12  2.3|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |  10        |
      Hemorrhage                           |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Atrophy, Focal                       | 2           1     1                                                      |     10  1.3|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Atrophy                              |                                                                          |      1  2.0|
      Focal Cellular Change                |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inflammation, Chronic                |                                                                          |      1  3.0|
      Ulcer                                |                                                                          |      1  3.0|
      Mucosa, Hyperplasia, Papillary       |                                                                          |      2  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  69                                                               
NTP Experiment-Test: 05089-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 16:21:47  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 0| 3| 3| 3| 3| 5| 5| 5| 5| 5|                                            |            |
                                           | 9| 0| 0| 0| 0| 7| 7| 8| 8| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |      A     |
    0.0275%                                | 0| 0| 0| 0| 0| 2| 2| 2| 2| 2|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inflammation, Chronic                |                                                                          |      1  1.0|
      Mucosa, Cyst                         |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   1        |
      Mesenteric Artery, Inflammation,     |                                                                          |            |
           Chronic                         |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Dilatation                           | 2                                                                        |      1  2.0|
      Thrombosis                           | 3                                                                        |      1  3.0|
      Pericardium, Edema                   | 2                                                                        |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Accessory Adrenal Cortical Nodule    |                                                                          |      1  2.0|
      Angiectasis                          |                                                                          |      2  2.0|
      Congestion                           |                                                                          |      2  2.0|
      Focal Cellular Change                |          2           1                                                   |     15  1.7|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Angiectasis                          |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     |                                                                          |      1  1.0|
      Hyperplasia                          |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperplasia                          |             3                                                            |      1  3.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Angiectasis                          |    2  3  2  2  1  2  1  2  2                                             |     49  2.2|
      Atrophy                              |                                                                          |      1  1.0|
      Cyst                                 |                                                                          |      6  1.8|
      Pars Distalis, Focal Cellular Change |                2        2  1                                             |      5  1.6|
      Pars Distalis, Hyperplasia, Focal    | 2           2     2                                                      |     11  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Degeneration, Cystic                 |             1                                                            |      2  1.0|
      C-Cell, Hyperplasia                  |                1  1  1  1  1                                             |     22  1.3|
      Follicular Cell, Hyperplasia         |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  70                                                               
NTP Experiment-Test: 05089-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 16:21:47  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 0| 3| 3| 3| 3| 5| 5| 5| 5| 5|                                            |            |
                                           | 9| 0| 0| 0| 0| 7| 7| 8| 8| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |      A     |
    0.0275%                                | 0| 0| 0| 0| 0| 2| 2| 2| 2| 2|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Degeneration, Cystic                 |                3                                                         |      2  3.0|
      Hyperplasia                          |    2           3                                                         |      8  2.1|
      Inflammation, Suppurative            |       2  3                                                               |      6  2.5|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Angiectasis                          |                   2                                                      |      1  2.0|
      Follicle, Cyst                       |                                                                          |      6  3.2|
      Periovarian Tissue, Cyst             |                2                                                         |      2  2.0|
                                            __________________________________________________________________________|____________|
   Oviduct                                 |                                                                          |   1        |
      Dilatation                           |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cyst                                 |                                                                          |      1  2.0|
      Hemorrhage                           |                                                                          |      2  3.0|
      Hydrometra                           |    2              2  2                                                   |      4  2.0|
      Intussusception                      |                                                                          |      1  3.0|
      Endometrium, Hyperplasia, Cystic     | 1  2  2  2           2                                                   |     28  1.7|
                                            __________________________________________________________________________|____________|
   Vagina                                  | +     +                                                                  |  11        |
      Cyst                                 |       2                                                                  |      7  2.5|
      Exudate, Mucous                      |                                                                          |      1  2.0|
      Inflammation, Suppurative            |                                                                          |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hypercellularity                     |             2                                                            |      5  2.8|
      Myelofibrosis                        |                   4  1  2                                                |      4  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inguinal, Inflammation, Suppurative  |                                                                          |      1  2.0|
      Mediastinal, Angiectasis             |                2  1  2     2                                             |     12  1.9|
      Mediastinal, Hyperplasia, Histiocytic|                         3                                                |      2  3.0|
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |      1  2.0|
      Mediastinal, Hyperplasia             |                                                                          |      1  2.0|
      Pancreatic, Angiectasis              |                                                                          |      1  2.0|
      Pancreatic, Hyperplasia, Lymphoid    |                                                                          |      1  3.0|
      Pancreatic, Hyperplasia              |                                                                          |      1  2.0|
      Renal, Angiectasis                   |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Hyperplasia                          |                                                                          |      1  2.0|
      Inflammation, Suppurative            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  71                                                               
NTP Experiment-Test: 05089-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 16:21:47  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 0| 3| 3| 3| 3| 5| 5| 5| 5| 5|                                            |            |
                                           | 9| 0| 0| 0| 0| 7| 7| 8| 8| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |      A     |
    0.0275%                                | 0| 0| 0| 0| 0| 2| 2| 2| 2| 2|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Angiectasis                          |                                                                          |      3  2.0|
      Hyperplasia, Histiocytic             |                         2                                                |      2  2.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Fibrosis                             |       2  2                                                               |      4  2.5|
      Hematopoietic Cell Proliferation     |                                                                          |      5  3.2|
      Hemorrhage                           |                                                                          |      1  3.0|
      Hyperplasia, Histiocytic, Lymphoid   |                                                                          |      8  2.5|
      Necrosis, Focal                      |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cyst                                 |                                                                          |      1  2.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
      Inflammation, Suppurative            |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Dilatation                           |    2  2  2  2                                                            |     42  1.8|
      Hyperplasia                          |                                                                          |      7  2.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inflammation, Chronic                |                                                                          |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperostosis                         |          1                                                               |      4  2.5|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Compression                          |                                                                          |      8  2.6|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hemorrhage                           | 2                                                                        |      1  2.0|
      Hyperplasia, Macrophage              |                         1                                                |      2  1.5|
      Inflammation, Chronic, Focal         |                                                                          |      1  1.0|
      Pigmentation                         |                         1                                                |      1  1.0|
      Alveolar Epithelium, Hyperplasia     |                1                                                         |      3  1.7|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Fungus                               |                2                                                         |      3  2.0|
      Inflammation, Suppurative            |                2                                                         |      3  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  72                                                               
NTP Experiment-Test: 05089-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 16:21:47  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 7| 7| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 0| 3| 3| 3| 3| 5| 5| 5| 5| 5|                                            |            |
                                           | 9| 0| 0| 0| 0| 7| 7| 8| 8| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |      A     |
    0.0275%                                | 0| 0| 0| 0| 0| 2| 2| 2| 2| 2|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Respiratory Epithelium, Degeneration,|                                                                          |            |
           Mucoid                          |                         2                                                |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   2        |
      Cataract                             |                                                                          |      1  2.0|
      Cornea, Inflammation, Chronic        |                                                                          |      1  2.0|
      Retina, Degeneration                 |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                +        +                                                |   6        |
      Hyperplasia, Lymphoid                |                2        2                                                |      5  1.8|
      Acinus, Dilatation                   |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Atrophy                              |                                                                          |      1  2.0|
      Inflammation, Suppurative            |                                                                          |      1  2.0|
      Mineralization                       |                         1  1                                             |      8  1.8|
      Nephropathy                          | 2  2  2  2  2     1  1  1  1                                             |     58  2.0|
      Pelvis, Transitional Epithelium,     |                                                                          |            |
           Hyperplasia                     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Transitional Epithelium, Hyperplasia |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  73                                                               
NTP Experiment-Test: 05089-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 16:21:47  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |
                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |            |
                                           | 3| 3| 4| 5| 5| 3| 3| 5| 5| 5|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|                                            |      A     |
    0.0275%                                | 3| 3| 3| 3| 3| 1| 1| 1| 1| 1|                                            |      L     |
    3 SSAC                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Granuloma                            |       1     1     1  1                                                   |      4  1.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  M  +  +  +  +                                             |   9        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  M  +  +  +  +                                             |   9        |
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  M  +  +  +  +                                             |   9        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Ultimobranchial Cyst                 |                   X                                                      |      1     |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Hydrometra                           |             2                                                            |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  74                                                               
NTP Experiment-Test: 05089-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 16:21:47  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |            |
                             DAY ON TEST   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |            |
                                           | 3| 3| 4| 5| 5| 3| 3| 5| 5| 5|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|                                            |      A     |
    0.0275%                                | 3| 3| 3| 3| 3| 1| 1| 1| 1| 1|                                            |      L     |
    3 SSAC                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  10        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         | +  +  +  +  +  +     +  +  +                                             |   9        |
      Hyperplasia, Glandular               | 2        2                                                               |      2  2.0|
      Hyperplasia, Lymphoid                | 2  1  2  2  1  1     1  1                                                |      8  1.4|
      Inflammation, Chronic                | 2  1  1  1  1  1     2                                                   |      7  1.3|
      Metaplasia, Squamous                 |       1                                                                  |      1  1.0|
      Necrosis                             | 1        1  1                                                            |      3  1.0|
      Acinus, Dilatation                   | 2        2  2        2     1                                             |      5  1.8|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  10        |
      Infiltration Cellular, Lymphocyte    | 2                                                                        |      1  2.0|
      Mineralization                       | 1  1  1  1  2  2  2     1  1                                             |      9  1.3|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  10        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  75                                                               
NTP Experiment-Test: 05089-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 16:21:47  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 7| 5| 6| 7| 7| 7| 3| 5| 7| 7| 7| 5| 6| 6| 7| 7| 5| 6| 7| 7| 7|             
                             DAY ON TEST   | 5| 1| 3| 3| 3| 5| 3| 3| 3| 3| 2| 7| 3| 3| 3| 9| 1| 9| 3| 3| 9| 7| 3| 3| 3|             
                                           | 1| 1| 2| 2| 2| 4| 9| 0| 0| 0| 9| 5| 2| 2| 2| 3| 4| 0| 0| 0| 6| 5| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0.0140%                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                1                                            1            |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                    2                     |             
      Congestion                           |                                                                          |             
      Fatty Change                         | 2                 2        3                                   2         |             
      Focal Cellular Change                |       1  2  2  1     2  2        1  2        1  1  1  2  2  2  2  1  2  2|             
      Granuloma                            |    1     1  2  1     2  2        1  1  1     1  2  1  3  1     1  2  1  2|             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hepatodiaphragmatic Nodule           |                                  2              3     2                  |             
      Hyperplasia, Multifocal              | 2                 2        2                                             |             
      Infiltration Cellular, Mixed Cell    |       2     2                                               2            |             
      Necrosis, Focal                      |                               2                                          |             
      Thrombosis                           |                                                                          |             
      Bile Duct, Hyperplasia               | 2  2     2  2     1  1     2        2  1        1  1  2  2           1  1|             
      Biliary Tract, Fibrosis              | 1  1        1     1  1     2        2  1        1     2  1           1   |             
      Centrilobular, Atrophy               | 2                 2        3  2                                          |             
      Centrilobular, Necrosis              |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               | +                 +     +  +        +              +        +  +         |             
      Angiectasis                          |                                                             3            |             
      Inflammation, Chronic                |                                                                3         |             
      Fat, Necrosis                        |                         2           2              4                     |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy, Focal                       |                   3                 1                 1     1     1     1|             
      Inflammation, Chronic                |                                                          3               |             
      Acinar Cell, Hyperplasia             |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Diverticulum                         |                                                                          |             
      Inflammation, Chronic                |                            3                                   4         |             
      Ulcer                                |                                                                2         |             
      Mucosa, Hyperplasia, Papillary       |                            3                                   3         |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                            3                                             |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  76                                                               
NTP Experiment-Test: 05089-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 16:21:47  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 7| 5| 6| 7| 7| 7| 3| 5| 7| 7| 7| 5| 6| 6| 7| 7| 5| 6| 7| 7| 7|             
                             DAY ON TEST   | 5| 1| 3| 3| 3| 5| 3| 3| 3| 3| 2| 7| 3| 3| 3| 9| 1| 9| 3| 3| 9| 7| 3| 3| 3|             
                                           | 1| 1| 2| 2| 2| 4| 9| 0| 0| 0| 9| 5| 2| 2| 2| 3| 4| 0| 0| 0| 6| 5| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0.0140%                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Inflammation, Chronic                |                                                                3         |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
      Mesenteric Artery, Aneurysm          |                                                                          |             
      Mesenteric Artery, Inflammation,     |                                                                          |             
           Chronic                         |                                                                          |             
      Mesenteric Artery, Thrombosis        |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                  2              2  3                     |             
      Focal Cellular Change                |    1  1     2        1                 1  1           1        2         |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                   1                       1              2     1         |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 2  2  3  2  2  1        2  3        4     2     1  3  2  2     3        3|             
      Cyst                                 |                2                                                         |             
      Pars Distalis, Hyperplasia, Focal    |          2           1                                            1      |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |                1        1                                      1         |             
      Follicle, Cyst                       |                                                       2                  |             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                3                                                         |             
      Hyperplasia                          |             1                                                            |             
      Inflammation, Suppurative            |                                                          3           2   |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicle, Cyst                       |                                                                          |             
      Periovarian Tissue, Cyst             |                                                 3           2            |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Hydrometra                           |                                                          3               |             
      Endometrium, Hyperplasia, Cystic     | 2        2           2  2  1     2  1     2  2  2     2  2  2     2  2  2|             
                                            __________________________________________________________________________|             
   Vagina                                  |                   +  +  +  +                    +                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  77                                                               
NTP Experiment-Test: 05089-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 16:21:47  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 7| 5| 6| 7| 7| 7| 3| 5| 7| 7| 7| 5| 6| 6| 7| 7| 5| 6| 7| 7| 7|             
                             DAY ON TEST   | 5| 1| 3| 3| 3| 5| 3| 3| 3| 3| 2| 7| 3| 3| 3| 9| 1| 9| 3| 3| 9| 7| 3| 3| 3|             
                                           | 1| 1| 2| 2| 2| 4| 9| 0| 0| 0| 9| 5| 2| 2| 2| 3| 4| 0| 0| 0| 6| 5| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0.0140%                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Cyst                                 |                         4                                                |             
      Exudate, Mucous                      |                                                                          |             
      Inflammation, Suppurative            |                   2  2                                                   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hypercellularity                     |                3                 2                    2  2  3            |             
      Myelofibrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mediastinal, Angiectasis             |       2              2                 2  3     2                        |             
      Mediastinal, Hyperplasia, Histiocytic|                                                                          |             
      Pancreatic, Angiectasis              |                                                                          |             
      Pancreatic, Hyperplasia, Lymphoid    |                                                 2                        |             
      Renal, Angiectasis                   |                                                 3                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                  2           2                           |             
      Hyperplasia                          |                                                                      2   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                     2                                    |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                          4               |             
      Fibrosis                             | 3                       1                                                |             
      Hematopoietic Cell Proliferation     |    2                                            3           3            |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Histiocytic, Lymphoid   |                      3                                4                  |             
      Capsule, Inflammation, Chronic       |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |             3        2                          2                        |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           | 1  2  3  2  2        2  2  2        2     2     1  2     2  2  2  2     2|             
      Hyperplasia                          |             2                                                            |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                          |             
      Hyperplasia, Squamous                |                                                                   2      |             
      Inflammation, Chronic                | 2                                                                        |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperostosis                         |       2           3              2                             3     2   |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  78                                                               
NTP Experiment-Test: 05089-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 16:21:47  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 7| 5| 6| 7| 7| 7| 3| 5| 7| 7| 7| 5| 6| 6| 7| 7| 5| 6| 7| 7| 7|             
                             DAY ON TEST   | 5| 1| 3| 3| 3| 5| 3| 3| 3| 3| 2| 7| 3| 3| 3| 9| 1| 9| 3| 3| 9| 7| 3| 3| 3|             
                                           | 1| 1| 2| 2| 2| 4| 9| 0| 0| 0| 9| 5| 2| 2| 2| 3| 4| 0| 0| 0| 6| 5| 2| 2| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|             
    0.0140%                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Compression                          |    3  3                             2                          3         |             
      Hemorrhage                           | 3                          2  3              3                           |             
      Necrosis                             |                                              3                           |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                               +                                          |             
      Hemorrhage                           |                               4                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                              3                           |             
      Hemorrhage                           |                                                                      2   |             
      Hyperplasia, Macrophage              |                                  1                                       |             
      Inflammation, Chronic, Focal         | 2                                                                        |             
      Inflammation, Pyogranulomatous       |                                                                          |             
      Alveolar Epithelium, Hyperplasia     | 2                          2                                             |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fungus                               |                                        1                             2   |             
      Hemorrhage                           |                                              3                           |             
      Inflammation, Suppurative            |                                        1                             2   |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
      Pinna, Hemorrhage                    |                                                                          |             
      Pinna, Inflammation, Chronic         |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                +         |             
      Cataract                             |                                                                3         |             
      Retina, Degeneration                 |                                                                4         |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Fibrosis                             |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Mineralization                       |                               1                                          |             
      Nephropathy                          |    3  3  2  3  2  2  2  2  2        1  1  3  1  1  1  2  2  2  4  2  3  2|             
      Pigmentation                         | 3                                                                        |             
      Renal Tubule, Degeneration, Hyaline  |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  79                                                               
NTP Experiment-Test: 05089-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 16:21:47  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 9| 9| 9| 3| 3| 3| 3| 3| 3| 6| 1| 2| 2| 2| 3| 3| 3| 3| 3|             
                                           | 7| 8| 8| 8| 9| 3| 4| 8| 9| 0| 0| 0| 0| 0| 0| 7| 1| 4| 9| 9| 0| 0| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    0.0140%                                | 1| 1| 1| 1| 1| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |                +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Parasite Metazoan                    |                   1  1                                            2  2   |             
                                            __________________________________________________________________________|             
   Intestine Small                         |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                         2                                         2      |             
      Congestion                           |                3                                                         |             
      Fatty Change                         |                1        3                                      2         |             
      Focal Cellular Change                |                1     2     2  2  2  2  2  2  2     2  2  1  2  2  2      |             
      Granuloma                            |                   2  2     2  1  1  3  2     2     2  2  1     1  1  2  1|             
      Hematopoietic Cell Proliferation     |                                              2                           |             
      Hepatodiaphragmatic Nodule           |                      3                             3                     |             
      Hyperplasia, Multifocal              |                         3                 1     2              2         |             
      Infiltration Cellular, Mixed Cell    |                                  2           2        1                  |             
      Necrosis, Focal                      |                   2                 2              1                     |             
      Thrombosis                           |                         2                                                |             
      Bile Duct, Hyperplasia               |                1  2  1  2     1     1  1  2     1  1  1  1  1  1  2  2  1|             
      Biliary Tract, Fibrosis              |                1  2     2  2  1     1     2     1  1  1     1  1        1|             
      Centrilobular, Atrophy               |                                           2     2              2         |             
      Centrilobular, Necrosis              |                         2                                                |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Angiectasis                          |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Fat, Necrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy, Focal                       |                                                                         2|             
      Inflammation, Chronic                |                                                                          |             
      Acinar Cell, Hyperplasia             |                                                             2            |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Diverticulum                         |                                                                          |             
      Inflammation, Chronic                |                                              1                           |             
      Ulcer                                |                                                                          |             
      Mucosa, Hyperplasia, Papillary       |                                              2                           |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  80                                                               
NTP Experiment-Test: 05089-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 16:21:47  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 9| 9| 9| 3| 3| 3| 3| 3| 3| 6| 1| 2| 2| 2| 3| 3| 3| 3| 3|             
                                           | 7| 8| 8| 8| 9| 3| 4| 8| 9| 0| 0| 0| 0| 0| 0| 7| 1| 4| 9| 9| 0| 0| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    0.0140%                                | 1| 1| 1| 1| 1| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                      +                                                   |             
      Mesenteric Artery, Aneurysm          |                      3                                                   |             
      Mesenteric Artery, Inflammation,     |                                                                          |             
           Chronic                         |                      3                                                   |             
      Mesenteric Artery, Thrombosis        |                      3                                                   |             
                                            __________________________________________________________________________|             
   Heart                                   |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Focal Cellular Change                |                                     2     1     2  1  1     2     2  1   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                            1        1  1                                 |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                   2     3  2  2  3  2  3  3        2  1  2  3  3  2  1  1|             
      Cyst                                 |                                                                          |             
      Pars Distalis, Hyperplasia, Focal    |                1     1                                   2           2  3|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |                   2           1  2     2  2                 2            |             
      Follicle, Cyst                       |                                                                          |             
      Follicular Cell, Hyperplasia         |                                              2                           |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Fibrosis                             |                                                                          |             
      Hyperplasia                          |                            2                       2                     |             
      Inflammation, Suppurative            |                      1           4                 2                     |             
                                            __________________________________________________________________________|             
   Ovary                                   |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicle, Cyst                       |                                  2                    1                  |             
      Periovarian Tissue, Cyst             |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                              2                           |             
      Hydrometra                           |                                                                3         |             
      Endometrium, Hyperplasia, Cystic     |                1  1  1  2  1  1  2  2           2  2  3  2  3  3  1  2  2|             
                                            __________________________________________________________________________|             
   Vagina                                  |                      +                          +  +        +            |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  81                                                               
NTP Experiment-Test: 05089-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 16:21:47  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 9| 9| 9| 3| 3| 3| 3| 3| 3| 6| 1| 2| 2| 2| 3| 3| 3| 3| 3|             
                                           | 7| 8| 8| 8| 9| 3| 4| 8| 9| 0| 0| 0| 0| 0| 0| 7| 1| 4| 9| 9| 0| 0| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    0.0140%                                | 1| 1| 1| 1| 1| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Cyst                                 |                      4                          2  2        2            |             
      Exudate, Mucous                      |                                                                          |             
      Inflammation, Suppurative            |                      4                                                   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hypercellularity                     |                            3                 X                           |             
      Myelofibrosis                        |                         3                                                |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mediastinal, Angiectasis             |                      2        2                                          |             
      Mediastinal, Hyperplasia, Histiocytic|                            3                                             |             
      Pancreatic, Angiectasis              |                                                                          |             
      Pancreatic, Hyperplasia, Lymphoid    |                                                                          |             
      Renal, Angiectasis                   |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                3                                                         |             
                                            __________________________________________________________________________|             
   Spleen                                  |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Fibrosis                             |                                                       1                  |             
      Hematopoietic Cell Proliferation     |                                              4     3                     |             
      Hemorrhage                           |                                                 2                        |             
      Hyperplasia, Histiocytic, Lymphoid   |                      3     4           2                                 |             
      Capsule, Inflammation, Chronic       |                                                 2                        |             
                                            __________________________________________________________________________|             
   Thymus                                  |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Cyst                                 |                                                             2            |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                2  2  2  2  2  2  2  2  2  2  2  2  3  1  1  2  2  2  2   |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                   2      |             
      Hyperplasia, Squamous                |                                                                          |             
      Inflammation, Chronic                |                                                                   3      |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperostosis                         |                   1              2              3              3  2  2  1|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  82                                                               
NTP Experiment-Test: 05089-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 16:21:47  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 6| 6| 6| 6| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 5| 5| 5| 5| 5| 5| 9| 9| 9| 3| 3| 3| 3| 3| 3| 6| 1| 2| 2| 2| 3| 3| 3| 3| 3|             
                                           | 7| 8| 8| 8| 9| 3| 4| 8| 9| 0| 0| 0| 0| 0| 0| 7| 1| 4| 9| 9| 0| 0| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    0.0140%                                | 1| 1| 1| 1| 1| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Compression                          |                         3        2                                2      |             
      Hemorrhage                           |                                                                          |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                3                                                         |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Macrophage              |                                                                          |             
      Inflammation, Chronic, Focal         |                                                                          |             
      Inflammation, Pyogranulomatous       |                               2                                          |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fungus                               |                                                    2                     |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Suppurative            |                3                                   2                     |             
                                            __________________________________________________________________________|             
   Trachea                                 |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                 +                        |             
      Pinna, Hemorrhage                    |                                                 1                        |             
      Pinna, Inflammation, Chronic         |                                                 1                        |             
                                            __________________________________________________________________________|             
   Eye                                     |                      +                                                   |             
      Cataract                             |                                                                          |             
      Retina, Degeneration                 |                      3                                                   |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                3                                                         |             
      Fibrosis                             |                            3        3           3                        |             
      Inflammation, Suppurative            |                                                 1                        |             
      Mineralization                       |                                                                          |             
      Nephropathy                          |                2  1  1  3  2  2  3  2  3  2  1  3  2  1  2  1  3  3  2  1|             
      Pigmentation                         |                                                                          |             
      Renal Tubule, Degeneration, Hyaline  |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  83                                                               
NTP Experiment-Test: 05089-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 16:21:47  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 4| 6| 7| 7| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 1| 8| 2| 2| 1| 5| 5| 5| 5|                                            |            |
                                           | 9| 1| 7| 4| 9| 8| 7| 9| 9| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |      A     |
    0.0140%                                | 7| 7| 7| 7| 7| 9| 9| 9| 9| 9|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +                                                         |  51        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +                                                         |  51        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +                                                         |  51        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +                                                         |  51        |
      Parasite Metazoan                    |                                                                          |      2  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +                                                         |  50        |
      Parasite Metazoan                    |                                                                          |      4  1.5|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +                                                         |  51        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  M  +  +                                                         |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +                                                         |  51        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +                                                         |  51        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +                                                         |  51        |
      Angiectasis                          |                                                                          |      3  2.0|
      Congestion                           |    3                                                                     |      2  3.0|
      Fatty Change                         |    2  3  3     3                                                         |     11  2.4|
      Focal Cellular Change                | 2        1  2                                                            |     36  1.7|
      Granuloma                            | 2  2        2                                                            |     36  1.6|
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
      Hepatodiaphragmatic Nodule           |             3  2                                                         |      7  2.6|
      Hyperplasia, Multifocal              |       2  2                                                               |      9  2.0|
      Infiltration Cellular, Mixed Cell    |                                                                          |      6  1.8|
      Necrosis, Focal                      | 1                                                                        |      5  1.6|
      Thrombosis                           |                                                                          |      1  2.0|
      Bile Duct, Hyperplasia               | 1     2  2  1  2                                                         |     37  1.4|
      Biliary Tract, Fibrosis              |       2  2  1  2                                                         |     29  1.3|
      Centrilobular, Atrophy               |       2  2                                                               |      9  2.1|
      Centrilobular, Necrosis              |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                +                                                         |   9        |
      Angiectasis                          |                                                                          |      1  3.0|
      Inflammation, Chronic                |                                                                          |      1  3.0|
      Fat, Necrosis                        |                                                                          |      3  2.7|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +                                                         |  51        |
      Atrophy, Focal                       |          2                                                               |      8  1.5|
      Inflammation, Chronic                |                                                                          |      1  3.0|
      Acinar Cell, Hyperplasia             |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +                                                         |  51        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +                                                         |  51        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +                                                         |  51        |
      Diverticulum                         | 1                                                                        |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  84                                                               
NTP Experiment-Test: 05089-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 16:21:47  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 4| 6| 7| 7| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 1| 8| 2| 2| 1| 5| 5| 5| 5|                                            |            |
                                           | 9| 1| 7| 4| 9| 8| 7| 9| 9| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |      A     |
    0.0140%                                | 7| 7| 7| 7| 7| 9| 9| 9| 9| 9|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Chronic                |                                                                          |      3  2.7|
      Ulcer                                |                                                                          |      1  2.0|
      Mucosa, Hyperplasia, Papillary       |                                                                          |      3  2.7|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +                                                         |  51        |
      Edema                                |                                                                          |      1  3.0|
      Inflammation, Chronic                |                2                                                         |      2  2.5|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   1        |
      Mesenteric Artery, Aneurysm          |                                                                          |      1  3.0|
      Mesenteric Artery, Inflammation,     |                                                                          |            |
           Chronic                         |                                                                          |      1  3.0|
      Mesenteric Artery, Thrombosis        |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +                                                         |  51        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +                                                         |  51        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +                                                         |  51        |
      Angiectasis                          |                                                                          |      3  2.3|
      Focal Cellular Change                |       2     1                                                            |     18  1.4|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +                                                         |  51        |
      Hyperplasia                          |             1                                                            |      8  1.1|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +                                                         |  51        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +                                                         |  51        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +                                                         |  50        |
      Angiectasis                          | 3  2  2        2                                                         |     36  2.3|
      Cyst                                 |                                                                          |      1  2.0|
      Pars Distalis, Hyperplasia, Focal    |                2                                                         |      9  1.7|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +                                                         |  51        |
      C-Cell, Hyperplasia                  |          2  2                                                            |     11  1.6|
      Follicle, Cyst                       |                                                                          |      1  2.0|
      Follicular Cell, Hyperplasia         |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +  +                                                         |  50        |
      Fibrosis                             |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  85                                                               
NTP Experiment-Test: 05089-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 16:21:47  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 4| 6| 7| 7| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 1| 8| 2| 2| 1| 5| 5| 5| 5|                                            |            |
                                           | 9| 1| 7| 4| 9| 8| 7| 9| 9| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |      A     |
    0.0140%                                | 7| 7| 7| 7| 7| 9| 9| 9| 9| 9|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia                          |                                                                          |      3  1.7|
      Inflammation, Suppurative            |                                                                          |      5  2.4|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +                                                         |  51        |
      Follicle, Cyst                       |                                                                          |      2  1.5|
      Periovarian Tissue, Cyst             |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +                                                         |  51        |
      Angiectasis                          |                                                                          |      1  2.0|
      Hydrometra                           |          3                                                               |      3  3.0|
      Endometrium, Hyperplasia, Cystic     | 1     1  2  2                                                            |     37  1.8|
                                            __________________________________________________________________________|____________|
   Vagina                                  | +     +  +  +                                                            |  13        |
      Cyst                                 | 3           3                                                            |      7  2.9|
      Exudate, Mucous                      |          3                                                               |      1  3.0|
      Inflammation, Suppurative            | 3           3                                                            |      5  2.8|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +                                                         |  51        |
      Hypercellularity                     |                                                                          |      7  2.5|
      Myelofibrosis                        |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +                                                         |  51        |
      Mediastinal, Angiectasis             |                                                                          |      7  2.1|
      Mediastinal, Hyperplasia, Histiocytic|                                                                          |      1  3.0|
      Pancreatic, Angiectasis              |    2                                                                     |      1  2.0|
      Pancreatic, Hyperplasia, Lymphoid    |                                                                          |      1  2.0|
      Renal, Angiectasis                   |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +  +                                                         |  51        |
      Angiectasis                          |                                                                          |      2  2.0|
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +                                                         |  49        |
      Angiectasis                          |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +                                                         |  51        |
      Congestion                           |                                                                          |      1  4.0|
      Fibrosis                             |       1                                                                  |      4  1.5|
      Hematopoietic Cell Proliferation     |                                                                          |      5  3.0|
      Hemorrhage                           |                                                                          |      1  2.0|
      Hyperplasia, Histiocytic, Lymphoid   |                                                                          |      5  3.2|
      Capsule, Inflammation, Chronic       |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +                                                         |  50        |
      Cyst                                 |                                                                          |      4  2.3|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  86                                                               
NTP Experiment-Test: 05089-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 16:21:47  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 4| 6| 7| 7| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 1| 8| 2| 2| 1| 5| 5| 5| 5|                                            |            |
                                           | 9| 1| 7| 4| 9| 8| 7| 9| 9| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |      A     |
    0.0140%                                | 7| 7| 7| 7| 7| 9| 9| 9| 9| 9|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +                                                         |  51        |
      Dilatation                           | 2     2  2  2                                                            |     40  2.0|
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +                                                         |  51        |
      Erosion                              |                                                                          |      1  2.0|
      Hyperplasia, Squamous                |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                                                          |      2  2.5|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +                                                         |  51        |
      Hyperostosis                         |             1                                                            |     13  2.1|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +                                                         |  51        |
      Compression                          |                                                                          |      7  2.6|
      Hemorrhage                           |                                                                          |      4  2.8|
      Necrosis                             |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
      Hemorrhage                           |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +                                                         |  51        |
      Congestion                           |                                                                          |      2  3.0|
      Hemorrhage                           |    1                                                                     |      2  1.5|
      Hyperplasia, Macrophage              |                                                                          |      1  1.0|
      Inflammation, Chronic, Focal         |                                                                          |      1  2.0|
      Inflammation, Pyogranulomatous       |                                                                          |      1  2.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +                                                         |  51        |
      Fungus                               |                                                                          |      3  1.7|
      Hemorrhage                           | 3                                                                        |      2  3.0|
      Inflammation, Suppurative            |                                                                          |      4  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +                                                         |  51        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   1        |
      Pinna, Hemorrhage                    |                                                                          |      1  1.0|
      Pinna, Inflammation, Chronic         |                                                                          |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  87                                                               
NTP Experiment-Test: 05089-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 16:21:47  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 4| 6| 7| 7| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 5| 1| 8| 2| 2| 1| 5| 5| 5| 5|                                            |            |
                                           | 9| 1| 7| 4| 9| 8| 7| 9| 9| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      T     |
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|                                            |      A     |
    0.0140%                                | 7| 7| 7| 7| 7| 9| 9| 9| 9| 9|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   2        |
      Cataract                             |                                                                          |      1  3.0|
      Retina, Degeneration                 |                                                                          |      2  3.5|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +                                                         |  51        |
      Congestion                           |                                                                          |      1  3.0|
      Fibrosis                             |                                                                          |      3  3.0|
      Inflammation, Suppurative            |                                                                          |      1  1.0|
      Mineralization                       |    1                                                                     |      2  1.0|
      Nephropathy                          | 2  1  1  1  2                                                            |     47  2.0|
      Pigmentation                         |                3                                                         |      2  3.0|
      Renal Tubule, Degeneration, Hyaline  |                3                                                         |      1  3.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +                                                         |  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  88                                                               
NTP Experiment-Test: 05089-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 16:21:47  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 3| 5| 6| 7| 7| 4| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 1| 1| 2| 3| 3| 7| 0| 5| 3| 3| 9| 2| 3| 3| 3| 3| 3| 3| 3| 3| 1| 2| 3| 3| 3|             
                                           | 4| 0| 2| 0| 0| 6| 8| 2| 1| 1| 4| 7| 1| 1| 1| 0| 1| 1| 1| 1| 0| 2| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    0.00700%                               | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |          1  2                                         1                  |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Congestion                           |                                                                          |             
      Fatty Change                         | 4  2           2     2  1  1  2              1              2  4  1      |             
      Focal Cellular Change                |    2  2  2  2  1        2  2        2  2  2  2  2  1  2  2  2     2  2  2|             
      Granuloma                            |    2  2  2  2  2  1        1  1  1  2     1  1  2  2  1  2  1     2  2  1|             
      Hematopoietic Cell Proliferation     |                   1                                                      |             
      Hepatodiaphragmatic Nodule           |       2        3                                                         |             
      Hyperplasia, Histiocytic, Lymphoid   |                                                    1                     |             
      Hyperplasia, Multifocal              | 2                    3     2           2                       2         |             
      Infiltration Cellular, Mixed Cell    |                   2        2                 2           2           2   |             
      Necrosis, Focal                      |                                                                          |             
      Bile Duct, Hyperplasia               | 1  1  1     1     2  2  1  1  1  1  1  1  2  2  1  1  1  1  1  1  1  1  1|             
      Biliary Tract, Fibrosis              | 1  2              2  1  1     1     1     1  1  1  1     1  1  1  1  1  1|             
      Centrilobular, Atrophy               | 2                    3                 2                       2         |             
      Centrilobular, Necrosis              |                      2                                                   |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                              +     +                     |             
      Inflammation, Chronic                |                                              2                           |             
      Fat, Necrosis                        |                                                    2                     |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy, Focal                       |    1        2                                   1                        |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                                             +            |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Inflammation, Chronic                |                               4                                          |             
      Ulcer                                |                               3                                          |             
      Mucosa, Hyperplasia, Papillary       |                               3                             2            |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  89                                                               
NTP Experiment-Test: 05089-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 16:21:47  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 3| 5| 6| 7| 7| 4| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 1| 1| 2| 3| 3| 7| 0| 5| 3| 3| 9| 2| 3| 3| 3| 3| 3| 3| 3| 3| 1| 2| 3| 3| 3|             
                                           | 4| 0| 2| 0| 0| 6| 8| 2| 1| 1| 4| 7| 1| 1| 1| 0| 1| 1| 1| 1| 0| 2| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    0.00700%                               | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Erosion                              |                                                                          |             
      Inflammation, Chronic                |                                              3                           |             
      Necrosis                             |                                                                2         |             
      Ulcer                                |                                              3                           |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                  +                                       |             
      Mesenteric Artery, Inflammation,     |                                                                          |             
           Chronic                         |                                  2                                       |             
      Mesenteric Artery, Thrombosis        |                                                                          |             
      Thoracic, Inflammation, Chronic      |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Focal Cellular Change                |          1              2  1                 1           2  2     2      |             
      Metaplasia, Osseous                  |                               2                                          |             
      Vacuolization Cytoplasmic            |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                            1                                            1|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 2  3  3  2  2        2  2  3  4  4  3  1  3  3  3  3  2  1  2  3  2     4|             
      Cyst                                 |                2                                                         |             
      Pars Distalis, Hyperplasia, Focal    |             2                          2              2  2               |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
      Ultimobranchial Cyst                 |                                                                          |             
      C-Cell, Hyperplasia                  |                                        1                          1      |             
      Follicle, Cyst                       |                                                                          |             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 |                                                                2         |             
      Hyperplasia                          |                         2                                                |             
      Inflammation, Suppurative            |                            2                                         3   |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  90                                                               
NTP Experiment-Test: 05089-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 16:21:47  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 3| 5| 6| 7| 7| 4| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 1| 1| 2| 3| 3| 7| 0| 5| 3| 3| 9| 2| 3| 3| 3| 3| 3| 3| 3| 3| 1| 2| 3| 3| 3|             
                                           | 4| 0| 2| 0| 0| 6| 8| 2| 1| 1| 4| 7| 1| 1| 1| 0| 1| 1| 1| 1| 0| 2| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    0.00700%                               | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Follicle, Cyst                       |                                              4                          3|             
      Periovarian Tissue, Cyst             |                   3                                                      |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |       4                                                                  |             
      Hydrometra                           |       3              1                                                   |             
      Inflammation, Suppurative            |                                                                          |             
      Prolapse                             |                                                                          |             
      Endometrium, Hyperplasia, Cystic     | 2  2  2     2        2  2  2     2  1  3  1  2  2  2     1     3  2     1|             
                                            __________________________________________________________________________|             
   Vagina                                  |                +              +           +  +     +     +     +         |             
      Cyst                                 |                3                          3  2           3     2         |             
      Inflammation, Suppurative            |                               2           3  2           3     2         |             
      Mucosa, Hyperplasia                  |                                                    2                     |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hypercellularity                     |                                                                      3  3|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inguinal, Hyperplasia                |                   2                                                      |             
      Mediastinal, Angiectasis             |                1                                                         |             
      Mediastinal, Hyperplasia, Lymphoid   |             2                                                            |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                   3                                                      |             
      Hyperplasia                          |                   2                                                      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                                                                          |             
      Hematopoietic Cell Proliferation     |       2           4                                                  2  2|             
      Hyperplasia, Histiocytic, Lymphoid   |       2  1  2                                                            |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hyperplasia, Lymphoid                |                            3                                             |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           | 1     1  2  2        2  2  2  2  2  2  2  2  1  2  2     2  1  1  2  2  2|             
      Fibrosis                             |                                                                          |             
      Hyperplasia                          |                      2                       2                           |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Sebaceous Gland, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperostosis                         |                      1        3  1              2                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  91                                                               
NTP Experiment-Test: 05089-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 16:21:47  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 3| 5| 6| 7| 7| 4| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 1| 1| 2| 3| 3| 7| 0| 5| 3| 3| 9| 2| 3| 3| 3| 3| 3| 3| 3| 3| 1| 2| 3| 3| 3|             
                                           | 4| 0| 2| 0| 0| 6| 8| 2| 1| 1| 4| 7| 1| 1| 1| 0| 1| 1| 1| 1| 0| 2| 0| 0| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
    0.00700%                               | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |    4                       3  2  4           3                    2     3|             
      Hemorrhage                           |                                                                          |             
      Hydrocephalus                        |                               2                                          |             
      Mineralization, Focal                |                                                             2            |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                                             1            |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Pyogranulomatous       |                                                             2            |             
      Alveolar Epithelium, Hyperplasia     |                                                 1                        |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                                                          |             
      Fungus                               |                                                                          |             
      Inflammation, Suppurative            |                                  1                 1                     |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |    +                                                                     |             
      Atrophy                              |    4                                                                     |             
      Cataract                             |                                                                          |             
      Retina, Degeneration                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
      Inflammation, Suppurative            |                                                                          |             
      Mineralization                       |                1                                                         |             
      Nephropathy                          | 3  3  2  2  2     1  3  3  3  1  3  2  1  2  4  3  2  1  1  2  2  2  1  1|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Transitional Epithelium, Hyperplasia |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  92                                                               
NTP Experiment-Test: 05089-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 16:21:47  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 5| 6| 7| 7| 7| 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 5| 5| 5| 5| 5| 9| 6| 0| 2| 2| 6| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2|             
                                           | 7| 7| 8| 8| 9| 6| 7| 8| 9| 9| 0| 6| 9| 9| 9| 4| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0.00700%                               | 8| 8| 8| 8| 8| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                 1                        |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                         3|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                        1           1                     |             
                                            __________________________________________________________________________|             
   Intestine Small                         |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                               4                                          |             
      Ulcer                                |                               3                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                           2                             2|             
      Congestion                           |                                                          2               |             
      Fatty Change                         |                      2  2     2  2        1                 2            |             
      Focal Cellular Change                |                2  2  2  2  2        2  2  2     2  2  2  2  2  1  2  2  2|             
      Granuloma                            |                2  2  1     2  2     2        1  1  1  1  1  1  2  1  2  1|             
      Hematopoietic Cell Proliferation     |                                              1                           |             
      Hepatodiaphragmatic Nodule           |                2  2        3  2                 2                 2     2|             
      Hyperplasia, Histiocytic, Lymphoid   |                                     2                                    |             
      Hyperplasia, Multifocal              |                                  2                 2                     |             
      Infiltration Cellular, Mixed Cell    |                         2              2                                 |             
      Necrosis, Focal                      |                         2        2                                       |             
      Bile Duct, Hyperplasia               |                1  2     1  1  2     1     1     1  1  2  1     2  1  1  1|             
      Biliary Tract, Fibrosis              |                1  1        1        1     1     1     1        2  1     1|             
      Centrilobular, Atrophy               |                                                                          |             
      Centrilobular, Necrosis              |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                              +                       +   |             
      Inflammation, Chronic                |                                              4                           |             
      Fat, Necrosis                        |                                                                      2   |             
                                            __________________________________________________________________________|             
   Pancreas                                |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy, Focal                       |                                                                2        1|             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                  3                                       |             
      Inflammation, Chronic                |                                                                          |             
      Ulcer                                |                                  1                                       |             
      Mucosa, Hyperplasia, Papillary       |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  93                                                               
NTP Experiment-Test: 05089-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 16:21:47  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 5| 6| 7| 7| 7| 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 5| 5| 5| 5| 5| 9| 6| 0| 2| 2| 6| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2|             
                                           | 7| 7| 8| 8| 9| 6| 7| 8| 9| 9| 0| 6| 9| 9| 9| 4| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0.00700%                               | 8| 8| 8| 8| 8| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Erosion                              |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Necrosis                             |                                                                          |             
      Ulcer                                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                              +                    +  +   |             
      Mesenteric Artery, Inflammation,     |                                                                          |             
           Chronic                         |                                                                   3  2   |             
      Mesenteric Artery, Thrombosis        |                                              3                           |             
      Thoracic, Inflammation, Chronic      |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                2         |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |                +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |                +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Focal Cellular Change                |                   1     1        2              1     2     1     3  1  1|             
      Metaplasia, Osseous                  |                                                                          |             
      Vacuolization Cytoplasmic            |                                  3                                       |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |                +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                         1|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |                +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                2  3  4  3  3           2  3     2  2  3  2  4  2  3  2  2|             
      Cyst                                 |                                              2                           |             
      Pars Distalis, Hyperplasia, Focal    |                                     1  2        2  2           2         |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                   2      |             
      Ultimobranchial Cyst                 |                                              1                           |             
      C-Cell, Hyperplasia                  |                1  1  1                                      1           1|             
      Follicle, Cyst                       |                         1                                                |             
      Follicular Cell, Hyperplasia         |                                                                   2      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 |                                                                          |             
      Hyperplasia                          |                                  2                                       |             
      Inflammation, Suppurative            |                            1                 1                           |             
                                            __________________________________________________________________________|             
   Ovary                                   |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  94                                                               
NTP Experiment-Test: 05089-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 16:21:47  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 5| 6| 7| 7| 7| 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 5| 5| 5| 5| 5| 9| 6| 0| 2| 2| 6| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2|             
                                           | 7| 7| 8| 8| 9| 6| 7| 8| 9| 9| 0| 6| 9| 9| 9| 4| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0.00700%                               | 8| 8| 8| 8| 8| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Follicle, Cyst                       |                   3                                               3      |             
      Periovarian Tissue, Cyst             |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Hydrometra                           |                                        2  3                              |             
      Inflammation, Suppurative            |                                                                          |             
      Prolapse                             |                                              4                           |             
      Endometrium, Hyperplasia, Cystic     |                   1  1           2  2  2     2     2        1     1  2  1|             
                                            __________________________________________________________________________|             
   Vagina                                  |                +  +              +     +                             +   |             
      Cyst                                 |                2  3                    3                             3   |             
      Inflammation, Suppurative            |                2  2                    3                             3   |             
      Mucosa, Hyperplasia                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hypercellularity                     |                                  3           3                           |             
                                            __________________________________________________________________________|             
   Lymph Node                              |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inguinal, Hyperplasia                |                                                                          |             
      Mediastinal, Angiectasis             |                                                    2                    2|             
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                     2                                    |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |                +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                    2                     |             
                                            __________________________________________________________________________|             
   Spleen                                  |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                               2                                          |             
      Hematopoietic Cell Proliferation     |                2     2  2        4           3                           |             
      Hyperplasia, Histiocytic, Lymphoid   |                   3                 1  1                                 |             
                                            __________________________________________________________________________|             
   Thymus                                  |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                2         |             
      Hyperplasia, Lymphoid                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                2  2  2  2  2     2  2  2  2     2  2  2  2  3  2  2     1|             
      Fibrosis                             |                                              2                           |             
      Hyperplasia                          |                         2                 2  2                           |             
                                            __________________________________________________________________________|             
   Skin                                    |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Sebaceous Gland, Hyperplasia         |                         3                                                |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperostosis                         |                      3                    2        2     2               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  95                                                               
NTP Experiment-Test: 05089-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 16:21:47  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 5| 6| 7| 7| 7| 5| 7| 7| 7| 7| 4| 7| 7| 7| 7| 6| 7| 7| 7| 7|             
                             DAY ON TEST   | 5| 5| 5| 5| 5| 9| 6| 0| 2| 2| 6| 2| 2| 2| 2| 2| 2| 2| 2| 2| 1| 2| 2| 2| 2|             
                                           | 7| 7| 8| 8| 9| 6| 7| 8| 9| 9| 0| 6| 9| 9| 9| 4| 9| 9| 9| 9| 9| 9| 9| 9| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
                               ANIMAL ID   | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    0.00700%                               | 8| 8| 8| 8| 8| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                  +                                       |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                      2                    3                 4            |             
      Hemorrhage                           |                                                                          |             
      Hydrocephalus                        |                                                                          |             
      Mineralization, Focal                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                                                          |             
      Hemorrhage                           |                                  1                                       |             
      Inflammation, Pyogranulomatous       |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                      3                          3                        |             
                                            __________________________________________________________________________|             
   Nose                                    |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                                                          |             
      Fungus                               |                3                          2     1                        |             
      Inflammation, Suppurative            |                3                          2     1           1            |             
                                            __________________________________________________________________________|             
   Trachea                                 |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                +  +                                                      |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                       +  +              +|             
      Atrophy                              |                                                                          |             
      Cataract                             |                                                       4  3              3|             
      Retina, Degeneration                 |                                                       4  4              3|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                     2                                    |             
      Inflammation, Suppurative            |                                                                          |             
      Mineralization                       |                                              1                           |             
      Nephropathy                          |                   2  4  4  2  1  2  2  2  3     2  2  2  1  1  2  2  2  2|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |                +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Transitional Epithelium, Hyperplasia |                                                                   3      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  96                                                               
NTP Experiment-Test: 05089-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 16:21:47  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 7| 7| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 1| 2| 2| 2| 2| 5| 5| 5| 5| 5|                                            |            |
                                           | 4| 1| 9| 9| 9| 7| 8| 8| 9| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |
    0.00700%                               | 4| 4| 4| 4| 4| 6| 6| 6| 6| 6|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +                                                            |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +                                                            |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +                                                            |  50        |
      Parasite Metazoan                    |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +                                                            |  50        |
      Cyst                                 |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +                                                            |  50        |
      Parasite Metazoan                    |                                                                          |      5  1.2|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +                                                            |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +                                                            |  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +                                                            |  50        |
      Fibrosis                             |                                                                          |      1  4.0|
      Ulcer                                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +                                                            |  50        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +                                                            |  50        |
      Angiectasis                          |                                                                          |      2  2.0|
      Congestion                           |                                                                          |      1  2.0|
      Fatty Change                         | 4        3                                                               |     19  2.1|
      Focal Cellular Change                |       1  2                                                               |     38  1.9|
      Granuloma                            |       1  1  2                                                            |     39  1.5|
      Hematopoietic Cell Proliferation     |                                                                          |      2  1.0|
      Hepatodiaphragmatic Nodule           |                                                                          |      9  2.2|
      Hyperplasia, Histiocytic, Lymphoid   |                                                                          |      2  1.5|
      Hyperplasia, Multifocal              |    2                                                                     |      8  2.1|
      Infiltration Cellular, Mixed Cell    |             2                                                            |      8  2.0|
      Necrosis, Focal                      |                                                                          |      2  2.0|
      Bile Duct, Hyperplasia               |    2  1  1  1                                                            |     42  1.2|
      Biliary Tract, Fibrosis              |    2  1  1  1                                                            |     31  1.1|
      Centrilobular, Atrophy               |    2                                                                     |      5  2.2|
      Centrilobular, Necrosis              |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               | +  +                                                                     |   6        |
      Inflammation, Chronic                |                                                                          |      2  3.0|
      Fat, Necrosis                        |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +                                                            |  50        |
      Atrophy, Focal                       | 2     2                                                                  |      7  1.6|
                                            __________________________________________________________________________|____________|
   Pharynx                                 |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +                                                            |  50        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +                                                            |  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +                                                            |  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  97                                                               
NTP Experiment-Test: 05089-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 16:21:47  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 7| 7| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 1| 2| 2| 2| 2| 5| 5| 5| 5| 5|                                            |            |
                                           | 4| 1| 9| 9| 9| 7| 8| 8| 9| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |
    0.00700%                               | 4| 4| 4| 4| 4| 6| 6| 6| 6| 6|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Edema                                |                                                                          |      1  3.0|
      Inflammation, Chronic                | 3        3                                                               |      3  3.3|
      Ulcer                                | 2                                                                        |      3  2.0|
      Mucosa, Hyperplasia, Papillary       | 2        3                                                               |      4  2.5|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +                                                            |  50        |
      Erosion                              |          1                                                               |      1  1.0|
      Inflammation, Chronic                |                                                                          |      1  3.0|
      Necrosis                             |                                                                          |      1  2.0|
      Ulcer                                |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |          +                                                               |   5        |
      Mesenteric Artery, Inflammation,     |                                                                          |            |
           Chronic                         |                                                                          |      3  2.3|
      Mesenteric Artery, Thrombosis        |                                                                          |      1  3.0|
      Thoracic, Inflammation, Chronic      |          2                                                               |      1  2.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +                                                            |  50        |
      Inflammation, Chronic                |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +                                                            |  49        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +                                                            |  49        |
      Focal Cellular Change                |                                                                          |     16  1.5|
      Metaplasia, Osseous                  |                                                                          |      1  2.0|
      Vacuolization Cytoplasmic            | 3        3                                                               |      3  3.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +                                                            |  49        |
      Hyperplasia                          |                                                                          |      3  1.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +                                                            |  50        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  M  +  +                                                            |  45        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +                                                            |  49        |
      Angiectasis                          | 2     2  2  2                                                            |     42  2.5|
      Cyst                                 |                                                                          |      2  2.0|
      Pars Distalis, Hyperplasia, Focal    |                                                                          |      9  1.9|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +                                                            |  48        |
      Fibrosis                             |                                                                          |      1  2.0|
      Ultimobranchial Cyst                 |                                                                          |      1  1.0|
      C-Cell, Hyperplasia                  |          1  1                                                            |      9  1.0|
      Follicle, Cyst                       |                                                                          |      1  1.0|
      Follicular Cell, Hyperplasia         |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  98                                                               
NTP Experiment-Test: 05089-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 16:21:47  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 7| 7| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 1| 2| 2| 2| 2| 5| 5| 5| 5| 5|                                            |            |
                                           | 4| 1| 9| 9| 9| 7| 8| 8| 9| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |
    0.00700%                               | 4| 4| 4| 4| 4| 6| 6| 6| 6| 6|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  +  +                                                            |  50        |
      Degeneration, Cystic                 |                                                                          |      1  2.0|
      Hyperplasia                          |                                                                          |      2  2.0|
      Inflammation, Suppurative            |             1                                                            |      5  1.6|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +                                                            |  50        |
      Follicle, Cyst                       |                                                                          |      4  3.3|
      Periovarian Tissue, Cyst             |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +                                                            |  50        |
      Hemorrhage                           |                                                                          |      1  4.0|
      Hydrometra                           |                                                                          |      4  2.3|
      Inflammation, Suppurative            |          1                                                               |      1  1.0|
      Prolapse                             |                                                                          |      1  4.0|
      Endometrium, Hyperplasia, Cystic     | 2  2  1  2                                                               |     33  1.8|
                                            __________________________________________________________________________|____________|
   Vagina                                  | +        +                                                               |  14        |
      Cyst                                 |                                                                          |      9  2.7|
      Inflammation, Suppurative            |          1                                                               |     10  2.3|
      Mucosa, Hyperplasia                  |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +                                                            |  50        |
      Hypercellularity                     |                                                                          |      4  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +                                                            |  50        |
      Inguinal, Hyperplasia                |                                                                          |      1  2.0|
      Mediastinal, Angiectasis             |                                                                          |      3  1.7|
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mandibular                  | +  +  +  +  +                                                            |  50        |
      Angiectasis                          |                                                                          |      2  2.5|
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +                                                            |  49        |
      Angiectasis                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +                                                            |  50        |
      Amyloid Deposition                   |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     |                                                                          |      9  2.6|
      Hyperplasia, Histiocytic, Lymphoid   |                                                                          |      6  1.7|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  M  +                                                            |  47        |
      Cyst                                 |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  99                                                               
NTP Experiment-Test: 05089-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 16:21:47  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 7| 7| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 1| 2| 2| 2| 2| 5| 5| 5| 5| 5|                                            |            |
                                           | 4| 1| 9| 9| 9| 7| 8| 8| 9| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |
    0.00700%                               | 4| 4| 4| 4| 4| 6| 6| 6| 6| 6|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +                                                            |  50        |
      Dilatation                           | 2  2  2  4  2                                                            |     43  1.9|
      Fibrosis                             |                                                                          |      1  2.0|
      Hyperplasia                          |                                                                          |      5  2.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +                                                            |  50        |
      Sebaceous Gland, Hyperplasia         |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +                                                            |  50        |
      Hyperostosis                         | 2        2                                                               |     10  2.0|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +                                                            |  50        |
      Compression                          |    3     2                                                               |     12  2.9|
      Hemorrhage                           | 3                                                                        |      1  3.0|
      Hydrocephalus                        |                                                                          |      1  2.0|
      Mineralization, Focal                |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +                                                            |  50        |
      Foreign Body                         |                                                                          |      1  1.0|
      Hemorrhage                           |                                                                          |      1  1.0|
      Inflammation, Pyogranulomatous       |                                                                          |      1  2.0|
      Alveolar Epithelium, Hyperplasia     |          2                                                               |      4  2.3|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +                                                            |  50        |
      Foreign Body                         |    2                                                                     |      1  2.0|
      Fungus                               |                                                                          |      3  2.0|
      Inflammation, Suppurative            |    3                                                                     |      7  1.7|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +                                                            |  49        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Eye                                     |       +                                                                  |   5        |
      Atrophy                              |                                                                          |      1  4.0|
      Cataract                             |       4                                                                  |      4  3.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 100                                                               
NTP Experiment-Test: 05089-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 16:21:47  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 6| 7| 7| 7| 4| 4| 4| 4| 4|                                            |            |
                             DAY ON TEST   | 1| 2| 2| 2| 2| 5| 5| 5| 5| 5|                                            |            |
                                           | 4| 1| 9| 9| 9| 7| 8| 8| 9| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   FISCHER 344 RATS FEMALE                 | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      A     |
    0.00700%                               | 4| 4| 4| 4| 4| 6| 6| 6| 6| 6|                                            |      L     |
                                           | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Retina, Degeneration                 |       4                                                                  |      4  3.8|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +                                                            |  50        |
      Fibrosis                             |                                                                          |      1  2.0|
      Inflammation, Suppurative            |          2                                                               |      1  2.0|
      Mineralization                       |                                                                          |      2  1.0|
      Nephropathy                          |       1  4  2                                                            |     45  2.1|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +                                                            |  50        |
      Transitional Epithelium, Hyperplasia |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page 101                                                               
NTP Experiment-Test: 05089-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 16:21:47  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 6| 7| 7| 7| 5| 6| 6| 7| 7| 5| 6| 7| 7| 7| 5| 5| 6| 7| 7| 4| 6| 6| 6| 7|             
                             DAY ON TEST   | 6| 0| 1| 3| 3| 7| 0| 2| 2| 2| 3| 7| 1| 1| 2| 1| 9| 5| 3| 3| 4| 6| 7| 7| 3|             
                                           | 1| 6| 0| 1| 1| 8| 5| 6| 9| 9| 9| 5| 0| 5| 9| 3| 1| 2| 1| 1| 6| 7| 4| 4| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                         2                                                |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |          1                 2        2  1                                 |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Metaplasia, Osseous                  |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                      2  1                                         2  1   |             
      Atrophy, Focal                       |                                                                          |             
      Basophilic Focus                     |                                                                          |             
      Congestion                           |                                                             3            |             
      Degeneration, Cystic                 |       2                 2           1     1           1  1        2     1|             
      Fatty Change                         | 1                             3                             1  2         |             
      Focal Cellular Change                |          1              2                                2     1        2|             
      Hemorrhage                           |                   2                                                      |             
      Hepatodiaphragmatic Nodule           |             3                       2        2           2               |             
      Hyperplasia, Multifocal              | 2     3                 2  2              2           2              3   |             
      Infiltration Cellular, Mixed Cell    |                               2              2                           |             
      Inflammation, Focal                  |    1                 2                       1           1  2  1  1     1|             
      Mineralization                       |                                                                          |             
      Necrosis, Focal                      |                                                                          |             
      Bile Duct, Hyperplasia               | 2     3  2  2     2  2  2  2  2  3  2  3  3  1  2  1  3  1  2  1  2  2  1|             
      Biliary Tract, Fibrosis              | 1     3  2  2        2  2  2  2  2  2  2  2  1  2  1  2  1  2     1  2  1|             
      Centrilobular, Atrophy               | 2                 3     1  1           2  2                              |             
                                            __________________________________________________________________________|             
   Mesentery                               | +     +     +  +  +  +  +     +  +  +  +  +     +  +  +  +        +  +   |             
      Hemorrhage                           |                                                                   3      |             
      Inflammation, Chronic                |                      1        2                    2              2  2   |             
      Fat, Necrosis                        |             3                                      2     3        2  3   |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy, Focal                       |    2           2     1     1              3     2                        |             
      Cytoplasmic Alteration               |                2                                                         |             
      Acinar Cell, Hyperplasia             |                                                       3  3               |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page 102                                                               
NTP Experiment-Test: 05089-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 16:21:47  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 6| 7| 7| 7| 5| 6| 6| 7| 7| 5| 6| 7| 7| 7| 5| 5| 6| 7| 7| 4| 6| 6| 6| 7|             
                             DAY ON TEST   | 6| 0| 1| 3| 3| 7| 0| 2| 2| 2| 3| 7| 1| 1| 2| 1| 9| 5| 3| 3| 4| 6| 7| 7| 3|             
                                           | 1| 6| 0| 1| 1| 8| 5| 6| 9| 9| 9| 5| 0| 5| 9| 3| 1| 2| 1| 1| 6| 7| 4| 4| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Inflammation, Chronic                |    3                 3        3                    2           3         |             
      Ulcer                                |    3                 2        2                                3         |             
      Mucosa, Hyperplasia, Papillary       |    3                 3        2                    2           3         |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              | 1                                         1                              |             
      Inflammation, Chronic                | 1  3                          2                    2              2      |             
      Mineralization                       |                                                                   3      |             
      Pigmentation, Focal                  | 1                                         1                              |             
      Ulcer                                |    3                                                                     |             
      Mucosa, Hyperplasia                  |                                                                   3      |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                              +                           |             
      Epithelium Alveolus, Cyst            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |          +           +                                   +        +      |             
      Aorta, Mineralization                |                                                                   3      |             
      Mesenteric Artery, Inflammation,     |                                                                          |             
           Chronic                         |          3           2                                   2               |             
      Mesenteric Artery, Mineralization    |                                                                   2      |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                                                                          |             
      Cyst                                 |                                                                          |             
      Focal Cellular Change                |                   1  1        1  2  1     2        1     1     1        1|             
      Hemorrhage                           |                                                                          |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Hyperplasia                          |          1                                2                             1|             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                    3           2  2      |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |    2  2                       3  2                    3        3     2  1|             
      Cyst                                 |                      2                                            2      |             
      Pigmentation                         |                                                                         3|             
      Pars Distalis, Focal Cellular Change |                                                             1            |             
      Pars Distalis, Hyperplasia, Focal    |                   2     2                       2                    1  3|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 |                                              1  1                 1     1|             
 _____________________________________________________________________________________________________________________|             
                                                             Page 103                                                               
NTP Experiment-Test: 05089-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 16:21:47  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 6| 7| 7| 7| 5| 6| 6| 7| 7| 5| 6| 7| 7| 7| 5| 5| 6| 7| 7| 4| 6| 6| 6| 7|             
                             DAY ON TEST   | 6| 0| 1| 3| 3| 7| 0| 2| 2| 2| 3| 7| 1| 1| 2| 1| 9| 5| 3| 3| 4| 6| 7| 7| 3|             
                                           | 1| 6| 0| 1| 1| 8| 5| 6| 9| 9| 9| 5| 0| 5| 9| 3| 1| 2| 1| 1| 6| 7| 4| 4| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pigmentation                         |             1                                                            |             
      Ultimobranchial Cyst                 |                                                                          |             
      C-Cell, Hyperplasia                  |             1              2                                   1         |             
      Follicle, Cyst                       |       1                                                                  |             
      Follicle, Hyperplasia, Macrophage    |                                                                          |             
      Follicular Cell, Hyperplasia         |                                                    1                     |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 | 3                       2                                                |             
      Fibrosis                             |                                  2                                       |             
      Inflammation, Suppurative            |                1        3  1  2     1  4     1     1  1  1     1     1  2|             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Suppurative            |       1           2        2  3        1              2  1  2  1        2|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
      Germinal Epithelium, Degeneration    |                               3     3     2        3  3        3  3  3  3|             
      Interstitial Cell, Hyperplasia       |                      2        1           1  2  2     2                  |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Myelofibrosis                        |                      1                             2              2      |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mediastinal, Angiectasis             |                            2                                             |             
      Mediastinal, Hyperplasia             |                                                                          |             
      Pancreatic, Hyperplasia              |                                                    2                     |             
      Renal, Angiectasis                   |                                                    2                     |             
                                            __________________________________________________________________________|             
   Lymph Node, Mandibular                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                   2      |             
      Hyperplasia                          |                                              2                           |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                    2                     |             
      Cyst                                 |                                     3                                    |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                        2                                 |             
      Hematopoietic Cell Proliferation     |                2                                                         |             
      Necrosis, Focal                      |                2  2                                                      |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page 104                                                               
NTP Experiment-Test: 05089-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 16:21:47  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 6| 7| 7| 7| 5| 6| 6| 7| 7| 5| 6| 7| 7| 7| 5| 5| 6| 7| 7| 4| 6| 6| 6| 7|             
                             DAY ON TEST   | 6| 0| 1| 3| 3| 7| 0| 2| 2| 2| 3| 7| 1| 1| 2| 1| 9| 5| 3| 3| 4| 6| 7| 7| 3|             
                                           | 1| 6| 0| 1| 1| 8| 5| 6| 9| 9| 9| 5| 0| 5| 9| 3| 1| 2| 1| 1| 6| 7| 4| 4| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Angiectasis                          |                                                                          |             
      Cyst                                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Dilatation                           |                            1  2        2              3  1     2         |             
      Hemorrhage                           |                                           2                              |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |    2                                                                     |             
      Cyst Epithelial Inclusion            |                                     2                                    |             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                               3                                          |             
      Hemorrhage                           | 4                                                                        |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Fibrosis, Focal                      |                                  2                                       |             
      Hemorrhage                           |                   1              2           2                           |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Hyperplasia, Macrophage              |                         3                                                |             
      Infiltration Cellular, Mixed Cell    |                               2                                          |             
      Inflammation, Acute                  |                                                                          |             
      Necrosis, Focal                      |                                  2                                       |             
      Alveolar Epithelium, Hyperplasia     |                                        2     2                    2      |             
      Mediastinum, Hemorrhage              |                                                                          |             
      Mediastinum, Inflammation, Chronic   |                                                                          |             
      Pleura, Inflammation, Chronic        |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fungus                               |                                                    1                     |             
      Inflammation, Suppurative            |          1              1        1     1  1        2        3            |             
      Mucosa, Hyperplasia, Squamous        |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Glands, Cyst                         |                                  2                                       |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                       +                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 105                                                               
NTP Experiment-Test: 05089-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 16:21:47  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 6| 7| 7| 7| 5| 6| 6| 7| 7| 5| 6| 7| 7| 7| 5| 5| 6| 7| 7| 4| 6| 6| 6| 7|             
                             DAY ON TEST   | 6| 0| 1| 3| 3| 7| 0| 2| 2| 2| 3| 7| 1| 1| 2| 1| 9| 5| 3| 3| 4| 6| 7| 7| 3|             
                                           | 1| 6| 0| 1| 1| 8| 5| 6| 9| 9| 9| 5| 0| 5| 9| 3| 1| 2| 1| 1| 6| 7| 4| 4| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Pinna, Hyperplasia, Squamous         |                                                       2                  |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                         +|             
      Atrophy                              |                                                                          |             
      Cataract                             |                                                                          |             
      Retina, Degeneration                 |                                                                          |             
      Retrobulbar, Inflammation, Chronic   |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                              +                           |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                2        4|             
      Nephropathy                          | 2  4  4  3  3  2  2  4  3  3  3  3  3  3  4  1  2  4  4  4  2  4  4  4  4|             
      Pelvis, Dilatation                   |                      1                                                   |             
      Pelvis, Transitional Epithelium,     |                                                                          |             
           Hyperplasia                     |                                                                          |             
      Renal Tubule, Hyperplasia            |                                                                   2      |             
                                            __________________________________________________________________________|             
   Urethra                                 |                                                                          |             
      Bulbourethral Gland, Dilatation      |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Transitional Epithelium, Hyperplasia |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 106                                                               
NTP Experiment-Test: 05089-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 16:21:47  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 5| 5| 6| 7| 7| 3| 5| 5| 7| 7| 5| 6| 6| 7| 7| 5| 6| 6| 6| 6|             
                             DAY ON TEST   | 5| 5| 5| 5| 5| 6| 7| 9| 2| 3| 1| 9| 9| 3| 3| 3| 1| 3| 2| 3| 1| 1| 5| 8| 9|             
                                           | 1| 7| 8| 9| 9| 9| 0| 4| 6| 1| 5| 8| 8| 1| 1| 7| 8| 8| 6| 1| 6| 8| 9| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    VEHICLE                                | 7| 7| 7| 7| 7| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Edema                                |                                                                      3   |             
      Hemorrhage                           |                                                                      1   |             
      Inflammation, Chronic                |                                                                      3   |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                1         |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Metaplasia, Osseous                  |                                                                   2      |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                   1     1     3                                      1   |             
      Atrophy, Focal                       |                                                                          |             
      Basophilic Focus                     |                                                                          |             
      Congestion                           |                                                                          |             
      Degeneration, Cystic                 |                            1              3                              |             
      Fatty Change                         | 1  1  2  1  1     1  2     2  2           1  2                       2  1|             
      Focal Cellular Change                |             1     2                    1  1        1     2               |             
      Hemorrhage                           |                                              1        2                  |             
      Hepatodiaphragmatic Nodule           |                                                                          |             
      Hyperplasia, Multifocal              |                      3  2                 2  2        2              2  3|             
      Infiltration Cellular, Mixed Cell    |                   2        2              2        2                     |             
      Inflammation, Focal                  | 1  2  2  1  2     2        2     2     2  2              2     2         |             
      Mineralization                       |                                                                          |             
      Necrosis, Focal                      |                               3     1                                    |             
      Bile Duct, Hyperplasia               | 2  2  1  2  2  1  1  2  3  2  3  2  2  2  2  2  2  2  2  2     2  2  2  3|             
      Biliary Tract, Fibrosis              |    2  1  1     1     2  2  2  3  2  1     2  1  2  2  2  1     2  2  2  2|             
      Centrilobular, Atrophy               |                      3  1           3        2  2                    2  3|             
                                            __________________________________________________________________________|             
   Mesentery                               |                      +     +  +     +  +                    +     +  +  +|             
      Hemorrhage                           |                                                                          |             
      Inflammation, Chronic                |                                                                   2      |             
      Fat, Necrosis                        |                            3           3                    1           2|             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy, Focal                       | 1                       2           2        1  1                       1|             
      Cytoplasmic Alteration               |                                                                          |             
      Acinar Cell, Hyperplasia             |                                                          3               |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page 107                                                               
NTP Experiment-Test: 05089-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 16:21:47  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 5| 5| 6| 7| 7| 3| 5| 5| 7| 7| 5| 6| 6| 7| 7| 5| 6| 6| 6| 6|             
                             DAY ON TEST   | 5| 5| 5| 5| 5| 6| 7| 9| 2| 3| 1| 9| 9| 3| 3| 3| 1| 3| 2| 3| 1| 1| 5| 8| 9|             
                                           | 1| 7| 8| 9| 9| 9| 0| 4| 6| 1| 5| 8| 8| 1| 1| 7| 8| 8| 6| 1| 6| 8| 9| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    VEHICLE                                | 7| 7| 7| 7| 7| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Inflammation, Chronic                |                      3           3                                       |             
      Ulcer                                |                      2           3                                       |             
      Mucosa, Hyperplasia, Papillary       |                                  3                                       |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                      2                                                   |             
      Inflammation, Chronic                |                      2           2        2                              |             
      Mineralization                       |                                                                          |             
      Pigmentation, Focal                  |                                                                          |             
      Ulcer                                |                                                                          |             
      Mucosa, Hyperplasia                  |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                +         |             
      Epithelium Alveolus, Cyst            |                                                                2         |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                          +               |             
      Aorta, Mineralization                |                                                                          |             
      Mesenteric Artery, Inflammation,     |                                                                          |             
           Chronic                         |                                                          2               |             
      Mesenteric Artery, Mineralization    |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                                                                          |             
      Cyst                                 |                                  2                                       |             
      Focal Cellular Change                |                   1                                   1                  |             
      Hemorrhage                           |                      4                                                   |             
      Necrosis                             |                      4                                                   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                      4                                                   |             
      Hyperplasia                          |                   1        1        1     2  2     1              1      |             
      Necrosis                             |                      3                                                   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                           3                              |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                4  3              3     3           3  3        3  2      |             
      Cyst                                 |                                                                          |             
      Pigmentation                         |                                                                          |             
      Pars Distalis, Focal Cellular Change |                                                                          |             
      Pars Distalis, Hyperplasia, Focal    |       1                    1                 1                           |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration, Cystic                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page 108                                                               
NTP Experiment-Test: 05089-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             CHLORAMINE                                        Date: 05/06/97  
Route: DOSED WATER                                                                                                Time: 16:21:47  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 4| 4| 4| 5| 5| 6| 7| 7| 3| 5| 5| 7| 7| 5| 6| 6| 7| 7| 5| 6| 6| 6| 6|             
                             DAY ON TEST   | 5| 5| 5| 5| 5| 6| 7| 9| 2| 3| 1| 9| 9| 3| 3| 3| 1| 3| 2| 3| 1| 1| 5| 8| 9|             
                                           | 1| 7| 8| 9| 9| 9| 0| 4| 6| 1| 5| 8| 8| 1| 1| 7| 8| 8| 6| 1| 6| 8| 9| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    VEHICLE                                | 7| 7| 7| 7| 7| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    CONTROL                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pigmentation                         |             1                                                            |             
      Ultimobranchial Cyst                 |                                           1                              |             
      C-Cell, Hyperplasia                  |             1                          2  1                              |             
      Follicle, Cyst                       |                                                                          |             
      Follicle, Hyperplasia, Macrophage    |             1                                                            |             
      Follicular Cell, Hyperplasia         |    1                                                                     |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |