TR 392 Rat Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Southern Research Inst CHLORAMINE DATE: 05/07/97
EXPERIMENT: 05089 TEST: 01 TIME: 16:06:18
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE PAGE: 1
CONT: N01-ES-45037 ROUTE: DOSED WATER NTP C#: C91004
PATHOLOGIST: D. FARNELL CAS: 10599903
------------------------------------------------------------------------------------------------------------------------------------
REASONS FOR REMOVAL: 25019 Moribund Sacrifice
25020 Natural Death
25021 Terminal Sacrifice
REMOVAL DATE RANGE: ALL
TREATMENT GROUPS: EXCLUDE 017 0.0275%
EXCLUDE 018 0.0275% 3 SSAC
EXCLUDE 019 0.0275%
EXCLUDE 020 0.0275% 3 SSAC
EXCLUDE 021 0.0140%
EXCLUDE 022 0.0140% 3 SSAC
EXCLUDE 023 0.0140%
EXCLUDE 024 0.0140% 3 SSAC
EXCLUDE 025 0.00700%
EXCLUDE 026 0.00700% 3 SSAC
EXCLUDE 027 0.00700%
EXCLUDE 028 0.00700% 3 SSAC
EXCLUDE 029 SENTINEL
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Southern Research Inst CHLORAMINE DATE: 05/07/97
EXPERIMENT: 05089 TEST: 01 TIME: 16:06:18
TEST TYPE: CHRONIC CAGES FROM 0000 TO LAST CAGE
CONT: N01-ES-45037 ROUTE: DOSED WATER NTP C#: C91004
PATHOLOGIST: D. FARNELL CAS: 10599903
CHLORAMINE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = VEHICLE CONTROL |
| ---------------------------- |
| |
| TOTAL 51 UNCENSORED DEATHS 37 CENSORED DEATHS 0 TERMINAL 14 |
| |
| UNCENSORED DEATHS |
| 315 361 446 451 465 513 516 537 539 541 |
| 569 570 578 591 598 598 605 606 618 618 |
| 626 638 652 659 667 674 674 675 687 694 |
| 695 697 710 710 715 726 726 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.00500% |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 28 CENSORED DEATHS 0 TERMINAL 22 |
| |
| UNCENSORED DEATHS |
| 473 579 581 601 605 613 614 618 625 627 |
| 645 653 654 654 661 662 667 668 668 675 |
| 676 676 695 701 701 701 715 718 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.0100% |
| --------------------- |
| |
| TOTAL 51 UNCENSORED DEATHS 37 CENSORED DEATHS 0 TERMINAL 14 |
| |
| UNCENSORED DEATHS |
| 429 447 519 530 533 549 562 566 583 586 |
| 590 590 591 591 596 605 614 618 625 631 |
| 639 656 666 668 669 674 675 675 690 696 |
| 698 701 702 703 710 719 719 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
CHLORAMINE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0.0200% |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 34 CENSORED DEATHS 0 TERMINAL 16 |
| |
| UNCENSORED DEATHS |
| 495 524 530 543 577 587 591 591 591 619 |
| 620 622 632 636 654 656 656 661 661 661 |
| 664 666 667 668 675 680 697 698 701 712 |
| 712 718 718 719 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
CHLORAMINE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|VEHICLE | 100.0 100.0 100.0 96.1 96.1 90.2 80.4 66.7 52.9 27.5 |
|CONTROL | |
| | |
|0.00500% | 100.0 100.0 100.0 100.0 100.0 98.0 98.0 90.0 68.0 44.0 |
| | |
| | |
|0.0100% | 100.0 100.0 100.0 100.0 100.0 96.1 90.2 68.6 56.9 27.5 |
| | |
| | |
|0.0200% | 100.0 100.0 100.0 100.0 100.0 100.0 92.0 82.0 58.0 32.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| VEHICLE 0.00500% 0.0100% 0.0200% |
| CONTROL |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 27.5% 44.0% 27.5% 32.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.870N P=0.049N P=0.984N P=0.433N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 601.6 647.4 622.0 641.2 |
|NATURAL DEATHS (C) | (16.5) ( 9.8) (12.0) (10.3) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 636.6 683.3 651.4 669.3 |
|(STANDARD ERROR) | (14.4) ( 7.9) (11.0) ( 9.1) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
CHLORAMINE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = VEHICLE CONTROL |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 19 CENSORED DEATHS 0 TERMINAL 31 |
| |
| UNCENSORED DEATHS |
| 472 508 531 569 578 620 639 650 666 666 |
| 667 668 668 673 675 702 703 712 721 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.00500% |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 22 CENSORED DEATHS 0 TERMINAL 28 |
| |
| UNCENSORED DEATHS |
| 299 348 452 540 570 576 622 626 626 641 |
| 652 656 662 695 698 702 703 714 719 719 |
| 719 726 |
| CENSORED DEATHS |
| NONE |
| |
|--------------------------------------------------------------------------------|
| DOSE = 0.0100% |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 21 CENSORED DEATHS 0 TERMINAL 29 |
| |
| UNCENSORED DEATHS |
| 200 456 465 509 560 584 590 605 619 620 |
| 628 667 668 676 697 698 698 704 719 719 |
| 726 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
CHLORAMINE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0.0200% |
| --------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 26 CENSORED DEATHS 0 TERMINAL 24 |
| |
| UNCENSORED DEATHS |
| 465 508 508 519 589 589 591 592 618 620 |
| 621 662 669 687 687 687 687 690 690 694 |
| 703 704 712 719 722 725 |
| CENSORED DEATHS |
| NONE |
| |
==================================================================================
CHLORAMINE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE RATS
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|VEHICLE | 100.0 100.0 100.0 100.0 100.0 98.0 94.0 90.0 84.0 62.0 |
|CONTROL | |
| | |
|0.00500% | 100.0 100.0 100.0 96.0 96.0 94.0 92.0 88.0 74.0 56.0 |
| | |
| | |
|0.0100% | 100.0 100.0 98.0 98.0 98.0 94.0 92.0 84.0 78.0 58.0 |
| | |
| | |
|0.0200% | 100.0 100.0 100.0 100.0 100.0 98.0 92.0 84.0 76.0 48.0 |
| | |
| | |
==================================================================================
==================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|--------------------------------------------------------------------------------|
| DOSE |
| |
| VEHICLE 0.00500% 0.0100% 0.0200% |
| CONTROL |
|--------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 62.0% 56.0% 58.0% 48.0% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.232 P=0.683 P=0.792 P=0.272 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 636.2 621.1 609.9 640.7 |
|NATURAL DEATHS (C) | (16.4) (25.3) (27.0) (14.8) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 693.7 681.5 679.0 683.1 |
|(STANDARD ERROR) | ( 8.9) (13.4) (14.0) ( 9.9) |
| | |
==================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
CHLORAMINE
KAPLAN-MEIER SURVIVAL CURVES
VEHICLE CONTROL = 1
0.00500% = 2
0.0100% = 3
0.0200% = 4
------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 1 3 2 4
| 1 1 3 3 2 4 4 2
| 1 1 1 33 4 2 2
| 1 1 334 4 22
90 + 1 1 3 3 44 22
| 1 1 3 3 4 4
| 3 3 222
| 11 4 4
P 80 + 1 1 3 3 2 2
E | 11 22
R | 1 1 4 4
C | 11 4 2 2
E 70 + 33
N | 1133 22
T | 1 13 4 4
| 33 22
S 60 + 1131 3
U | 1 1 43
R | 1 1 2 22
V | 114
I 50 + 114
V | 4 42 2
A | 1 144 2 2
L | 1144
40 + 33
| 1 14
|
| 3111 4
30 +
| 31 1
|
|
20 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 37 obs hidden.
CHLORAMINE
KAPLAN-MEIER SURVIVAL CURVES
VEHICLE CONTROL = 1
0.00500% = 2
0.0100% = 3
0.0200% = 4
----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 3 2 41
| 3 2 2 341 1
| 2 233 1 41 2 1
| 3 4 2 3 11 4
P 90 + 3 213 1
E | 23 3 1 1
R | 3 3 22 11 1
C | 2 2
E 80 + 33 2 2
N | 43 43
T | 2 211 42
| 3 3
S 70 + 1 21
U |
R | 3111
V | 44 1 1
I 60 + 44 33
V | 22 3
A | 4442 2
L | 44
50 +
| 4 4
|
|
40 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 34 obs hidden.
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