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TR 393 Mouse Pathology Tables


                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                          SODIUM FLUORIDE


NTP Experiment-Test: 05131-02                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 09/17/94
Route: DOSED WATER                                                                                                Time: 08:28:02




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  7681-49-4

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05131-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 09/17/94  
Route: DOSED WATER                                                                                                Time: 08:28:02  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                         0 PPM       SPECIAL       25 PPM       100 PPM      175 PPM                     
                                                                CONTROL                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                         100           50           70           70           99                        
  Scheduled Sacrifice                                 20                        18           20           19                        
  Early Deaths                                                                                                                      
    Natural Death                                     13            7            5            7           16                        
    Moribund Sacrifice                                14            6            9            9           12                        
  Survivors                                                                                                                         
    Terminal Sacrifice                                53            8           38           32           51                        
    Natural Death                                                                             2            1                        
  Special Control                                                  29                                                               
  Animals Examined Microscopically                   100           42           62           63           99                        
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (99)         (40)         (59)         (58)         (98)                      
      Histiocytic Sarcoma                                                        1 (2%)                    1 (1%)                   
   Intestine Large, Cecum                             (100)        (42)         (60)         (59)         (97)                      
   Intestine Large, Rectum                            (99)         (42)         (60)         (59)         (98)                      
      Histiocytic Sarcoma                                                                     1 (2%)                                
   Intestine Small, Duodenum                          (100)        (42)         (60)         (58)         (98)                      
      Fibrosarcoma, Metastatic, Skin                   1 (1%)                                                                       
      Histiocytic Sarcoma                                                                     1 (2%)                                
   Intestine Small, Ileum                             (98)         (42)         (60)         (59)         (97)                      
      Fibrosarcoma, Metastatic, Skin                                1 (2%)                                                          
      Histiocytic Sarcoma                                                                     1 (2%)                                
   Intestine Small, Jejunum                           (100)        (42)         (60)         (59)         (97)                      
      Hemangiosarcoma                                                                         1 (2%)                                
      Histiocytic Sarcoma                                                                     1 (2%)                                
   Liver                                              (100)        (42)         (60)         (60)         (99)                      
      Hemangioma                                       1 (1%)                    1 (2%)                    1 (1%)                   
      Hemangiosarcoma                                  2 (2%)       1 (2%)                                 1 (1%)                   
      Hepatoblastoma                                                             1 (2%)                    2 (2%)                   
      Hepatocellular Carcinoma                        13 (13%)      3 (7%)       9 (15%)      7 (12%)     12 (12%)                  
      Hepatocellular Carcinoma, Multiple               1 (1%)                    2 (3%)       1 (2%)       1 (1%)                   
      Hepatocellular Adenoma                          25 (25%)      4 (10%)     11 (18%)     12 (20%)     19 (19%)                  
      Hepatocellular Adenoma, Multiple                27 (27%)      5 (12%)     21 (35%)     14 (23%)     17 (17%)                  
      Hepatocholangiocarcinoma                                      1 (2%)                                 1 (1%)                   
      Histiocytic Sarcoma                              4 (4%)                    1 (2%)       2 (3%)       5 (5%)                   
      Osteosarcoma, Metastatic, Bone                   1 (1%)                                                                       
      Osteosarcoma, Metastatic, Uncertain Primary                                                                                   
          Site                                                                   1 (2%)                                             
   Mesentery                                          (28)         (6)          (16)         (18)         (28)                      
      Fibrosarcoma, Metastatic, Skin                   1 (4%)       1 (17%)      1 (6%)                                             
                                                             Page   2                                                               
NTP Experiment-Test: 05131-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 09/17/94  
Route: DOSED WATER                                                                                                Time: 08:28:02  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                         0 PPM       SPECIAL       25 PPM       100 PPM      175 PPM                     
                                                                CONTROL                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - cont                                                                                                            
      Hemangioma                                                                 1 (6%)                                             
      Hepatocholangiocarcinoma, Metastatic, Liver                                                          1 (4%)                   
      Histiocytic Sarcoma                              2 (7%)                    2 (13%)      1 (6%)       3 (11%)                  
      Lipoma                                                                                               1 (4%)                   
      Sarcoma, Metastatic, Uncertain Primary Site                                                          1 (4%)                   
   Pancreas                                           (100)        (42)         (60)         (59)         (98)                      
      Fibrosarcoma, Metastatic, Skin                   1 (1%)       1 (2%)                                                          
      Hepatoblastoma, Metastatic, Liver                                                                    1 (1%)                   
      Hepatocholangiocarcinoma, Metastatic, Liver                                                          1 (1%)                   
      Histiocytic Sarcoma                              2 (2%)                    2 (3%)       1 (2%)       1 (1%)                   
      Acinus, Adenocarcinoma                           1 (1%)                                                                       
   Salivary Glands                                    (99)         (41)         (60)         (60)         (99)                      
      Histiocytic Sarcoma                                                                                  1 (1%)                   
   Stomach, Forestomach                               (100)        (42)         (60)         (59)         (98)                      
      Mast Cell Tumor Malignant                                                               1 (2%)                                
      Squamous Cell Papilloma                          3 (3%)                    4 (7%)       2 (3%)       3 (3%)                   
      Squamous Cell Papilloma, Multiple                                                                    1 (1%)                   
   Stomach, Glandular                                 (100)        (42)         (60)         (59)         (98)                      
      Histiocytic Sarcoma                                                                     1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (99)         (41)         (60)         (60)         (99)                      
      Hemangiosarcoma                                                            1 (2%)                                             
      Hemangiosarcoma, Metastatic, Liver                                                                   1 (1%)                   
      Hepatoblastoma, Metastatic, Liver                                                                    1 (1%)                   
      Hepatocholangiocarcinoma, Metastatic, Liver                   1 (2%)                                                          
      Histiocytic Sarcoma                              2 (2%)                                 1 (2%)       2 (2%)                   
      Pericardium, Hepatocholangiocarcinoma,                                                                                        
          Metastatic, Liver                                                                                1 (1%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (99)         (42)         (60)         (60)         (99)                      
      Histiocytic Sarcoma                                                        1 (2%)       2 (3%)       1 (1%)                   
      Sarcoma, Metastatic, Uncertain Primary Site                                                          1 (1%)                   
   Adrenal Gland, Medulla                             (96)         (42)         (60)         (60)         (98)                      
      Pheochromocytoma Benign                                                    1 (2%)       1 (2%)       1 (1%)                   
      Bilateral, Pheochromocytoma Benign                                         1 (2%)                                             
   Islets, Pancreatic                                 (99)         (41)         (60)         (59)         (99)                      
      Adenoma                                          1 (1%)                    1 (2%)       1 (2%)       1 (1%)                   
      Fibrosarcoma, Metastatic, Skin                                1 (2%)                                                          
      Histiocytic Sarcoma                                                                     1 (2%)                                
   Pituitary Gland                                    (100)        (41)         (59)         (61)         (97)                      
      Histiocytic Sarcoma                                                                                  2 (2%)                   
                                                             Page   3                                                               
NTP Experiment-Test: 05131-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 09/17/94  
Route: DOSED WATER                                                                                                Time: 08:28:02  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                         0 PPM       SPECIAL       25 PPM       100 PPM      175 PPM                     
                                                                CONTROL                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - cont                                                                                                             
      Pars Distalis, Adenoma                          22 (22%)      3 (7%)       6 (10%)      8 (13%)     13 (13%)                  
      Pars Distalis, Adenoma, Multiple                 3 (3%)                    1 (2%)                                             
   Thyroid Gland                                      (100)        (42)         (60)         (60)         (99)                      
      C-Cell, Carcinoma                                                                       1 (2%)                                
      Follicular Cell, Adenocarcinoma                                            1 (2%)                                             
      Follicular Cell, Adenoma                         3 (3%)       2 (5%)                                 2 (2%)                   
      Follicular Cell, Adenoma, Multiple               1 (1%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (98)         (41)         (57)         (58)         (98)                      
      Cystadenoma                                                                                          1 (1%)                   
      Cystadenoma, Papillary                           3 (3%)                    1 (2%)                    1 (1%)                   
      Fibrosarcoma, Metastatic, Skin                   1 (1%)       1 (2%)                                                          
      Granulosa Cell Tumor Benign                      1 (1%)                                                                       
      Hemangiosarcoma                                                            1 (2%)                                             
      Histiocytic Sarcoma                              2 (2%)                    1 (2%)       1 (2%)       3 (3%)                   
      Luteoma                                          1 (1%)                                                                       
      Sarcoma, Metastatic, Uncertain Primary Site                                                          1 (1%)                   
   Uterus                                             (100)        (42)         (60)         (60)         (99)                      
      Hemangioma                                       2 (2%)                                                                       
      Hemangiosarcoma                                               1 (2%)                    1 (2%)                                
      Histiocytic Sarcoma                              4 (4%)                    1 (2%)       1 (2%)       4 (4%)                   
      Polyp Stromal                                    3 (3%)                    1 (2%)       1 (2%)       1 (1%)                   
      Sarcoma Stromal                                                                                      1 (1%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Blood                                              (2)          (1)                                                              
      Histiocytic Sarcoma                              1 (50%)                                                                      
   Bone Marrow                                        (100)        (42)         (62)         (61)         (99)                      
      Femoral, Hemangiosarcoma                         1 (1%)                    1 (2%)       1 (2%)                                
      Femoral, Histiocytic Sarcoma                     2 (2%)                                 1 (2%)       2 (2%)                   
      Humerus, Hemangiosarcoma                                                                1 (2%)                                
      Humerus, Histiocytic Sarcoma                     1 (1%)                                                                       
      Maxilla, Histiocytic Sarcoma                                                                         1 (1%)                   
      Thoracic, Vertebra, Histiocytic Sarcoma                                                              1 (1%)                   
      Tibia, Histiocytic Sarcoma                       2 (2%)                                                                       
   Lymph Node                                         (100)        (42)         (60)         (60)         (99)                      
      Inguinal, Histiocytic Sarcoma                                                                        1 (1%)                   
                                                             Page   4                                                               
NTP Experiment-Test: 05131-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 09/17/94  
Route: DOSED WATER                                                                                                Time: 08:28:02  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                         0 PPM       SPECIAL       25 PPM       100 PPM      175 PPM                     
                                                                CONTROL                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - cont                                                                                                         
      Lumbar, Fibrosarcoma, Metastatic, Skin                        1 (2%)                                                          
      Lumbar, Histiocytic Sarcoma                      1 (1%)                                                                       
      Mediastinal, Hepatoblastoma, Metastatic,                                                                                      
           Liver                                                                                           1 (1%)                   
      Mediastinal, Hepatocholangiocarcinoma,                                                                                        
          Metastatic, Liver                                         1 (2%)                                                          
      Mediastinal, Histiocytic Sarcoma                 1 (1%)                    2 (3%)       1 (2%)       2 (2%)                   
      Renal, Fibrosarcoma, Metastatic, Skin                         1 (2%)                                                          
      Renal, Histiocytic Sarcoma                       1 (1%)                                                                       
   Lymph Node, Mandibular                             (96)         (42)         (60)         (56)         (98)                      
      Hemangioma                                       1 (1%)                                                                       
      Histiocytic Sarcoma                              3 (3%)                                 1 (2%)       3 (3%)                   
   Lymph Node, Mesenteric                             (99)         (40)         (57)         (57)         (94)                      
      Fibrosarcoma, Metastatic, Skin                                1 (3%)                                                          
      Hemangioma                                                                                           1 (1%)                   
      Histiocytic Sarcoma                              2 (2%)                    1 (2%)       1 (2%)       3 (3%)                   
   Spleen                                             (99)         (42)         (60)         (59)         (99)                      
      Hemangiosarcoma                                  1 (1%)                                                                       
      Histiocytic Sarcoma                              1 (1%)                    2 (3%)       1 (2%)       2 (2%)                   
   Thymus                                             (96)         (42)         (56)         (55)         (92)                      
      Histiocytic Sarcoma                              1 (1%)                    1 (2%)                    2 (2%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (98)         (41)         (59)         (60)         (99)                      
      Adenocarcinoma                                   1 (1%)                    1 (2%)                                             
      Adenoma                                                                                              1 (1%)                   
      Histiocytic Sarcoma                                                                     1 (2%)                                
   Skin                                               (100)        (42)         (60)         (60)         (99)                      
      Histiocytic Sarcoma                                                                     1 (2%)                                
      Subcutaneous Tissue, Fibrosarcoma                2 (2%)       2 (5%)       2 (3%)                    5 (5%)                   
      Subcutaneous Tissue, Hemangiosarcoma                          1 (2%)                                                          
      Subcutaneous Tissue, Mast Cell Tumor                                                                                          
          Malignant                                                              1 (2%)                                             
      Subcutaneous Tissue, Neurofibrosarcoma                                                               1 (1%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (90)         (42)         (60)         (60)         (89)                      
      Femur, Osteosarcoma                              1 (1%)                                                                       
      Femur, Synovial Tissue, Sarcoma                  1 (1%)                                                                       
      Humerus, Hemangiosarcoma                         1 (1%)                                                                       
      Maxilla, Adenocarcinoma, Metastatic,                                                                                          
          Harderian Gland                              1 (1%)                                                                       
      Rib, Osteoma                                     1 (1%)                                                                       
                                                             Page   5                                                               
NTP Experiment-Test: 05131-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 09/17/94  
Route: DOSED WATER                                                                                                Time: 08:28:02  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                         0 PPM       SPECIAL       25 PPM       100 PPM      175 PPM                     
                                                                CONTROL                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
MUSCULOSKELETAL SYSTEM - cont                                                                                                       
   Skeletal Muscle                                    (12)         (1)                       (1)          (11)                      
      Fibrosarcoma, Metastatic, Skin                                                                       1 (9%)                   
      Histiocytic Sarcoma                              1 (8%)                                 1 (100%)                              
      Osteosarcoma, Metastatic, Bone                   1 (8%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (100)        (42)         (60)         (60)         (99)                      
      Histiocytic Sarcoma                                                                                  1 (1%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (100)        (42)         (60)         (60)         (99)                      
      Adenocarcinoma, Metastatic, Harderian Gland      1 (1%)                    1 (2%)                                             
      Alveolar/Bronchiolar Adenoma                     5 (5%)       2 (5%)       3 (5%)       2 (3%)       4 (4%)                   
      Alveolar/Bronchiolar Adenoma, Multiple                                     1 (2%)                                             
      Alveolar/Bronchiolar Carcinoma                   3 (3%)                    2 (3%)       2 (3%)       3 (3%)                   
      Fibrosarcoma, Metastatic, Skin                                                                       1 (1%)                   
      Hepatoblastoma, Metastatic, Liver                                                                    1 (1%)                   
      Hepatocellular Carcinoma, Metastatic, Liver      1 (1%)                    1 (2%)       1 (2%)       2 (2%)                   
      Hepatocholangiocarcinoma, Metastatic, Liver                   1 (2%)                                 1 (1%)                   
      Histiocytic Sarcoma                              3 (3%)                    1 (2%)       2 (3%)       3 (3%)                   
      Osteosarcoma, Metastatic, Bone                   1 (1%)                                                                       
      Osteosarcoma, Metastatic, Uncertain Primary                                                                                   
          Site                                                                   1 (2%)                                             
      Mediastinum, Fibrosarcoma, Metastatic, Skin      1 (1%)                                                                       
      Mediastinum, Hepatocellular Carcinoma,                                                                                        
          Metastatic, Liver                                                                                1 (1%)                   
   Nose                                               (100)        (42)         (60)         (60)         (99)                      
      Adenocarcinoma, Metastatic, Harderian Gland      1 (1%)                                                                       
      Histiocytic Sarcoma                                                                     1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                                          (1)          (1)          (1)                       
      Fibrosarcoma                                                               1 (100%)                                           
      Squamous Cell Papilloma                                                                 1 (100%)                              
   Harderian Gland                                    (66)         (36)         (48)         (45)         (52)                      
      Adenocarcinoma                                   1 (2%)                    1 (2%)                                             
      Adenoma                                          4 (6%)       1 (3%)       2 (4%)       7 (16%)      2 (4%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   6                                                               
NTP Experiment-Test: 05131-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 09/17/94  
Route: DOSED WATER                                                                                                Time: 08:28:02  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                         0 PPM       SPECIAL       25 PPM       100 PPM      175 PPM                     
                                                                CONTROL                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (100)        (42)         (60)         (60)         (99)                      
      Fibrosarcoma, Metastatic, Skin                   1 (1%)                                                                       
      Histiocytic Sarcoma                              3 (3%)                    2 (3%)       1 (2%)       4 (4%)                   
   Urinary Bladder                                    (100)        (42)         (60)         (60)         (97)                      
      Histiocytic Sarcoma                              3 (3%)                                 1 (2%)       1 (1%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(100)       *(42)        *(62)        *(63)        *(99)                      
      Histiocytic Sarcoma                              5 (5%)                    3 (5%)       2 (3%)       5 (5%)                   
      Lymphoma Malignant Lymphocytic                   2 (2%)                                 1 (2%)       5 (5%)                   
      Lymphoma Malignant Mixed                         4 (4%)                    5 (8%)       7 (11%)      8 (8%)                   
      Lymphoma Malignant Undifferentiated Cell         5 (5%)       1 (2%)                    3 (5%)       6 (6%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   7                                                               
NTP Experiment-Test: 05131-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 09/17/94  
Route: DOSED WATER                                                                                                Time: 08:28:02  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                         0 PPM       SPECIAL       25 PPM       100 PPM      175 PPM                     
                                                                CONTROL                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            77          17          45          40          65                           
     Total Primary Neoplasms                          152          27          88          78         121                           
                                                                                                                                    
   Total Animals with Benign Neoplasms                 69          12          38          32          48                           
     Total Benign Neoplasms                           107          17          56          49          70                           
                                                                                                                                    
   Total Animals with Malignant Neoplasms              35           9          26          25          44                           
     Total Malignant Neoplasms                         45          10          32          29          51                           
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              5           2           4           1           8                           
     Total Metastatic Neoplasm                         13          11           5           1          17                           
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                       1                       1                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   8                                                               
NTP Experiment-Test: 05131-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 09/17/94  
Route: DOSED WATER                                                                                                Time: 08:28:02  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                           0 PPM       SPECIAL       25 PPM       100 PPM      175 PPM                     
                                                                CONTROL                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          99           50           70           70          100                        
  Scheduled Sacrifice                                 20                        20           19           20                        
  Early Deaths                                                                                                                      
    Natural Death                                     16            3            8            6           11                        
    Moribund Sacrifice                                 5            9            3            8            4                        
  Survivors                                                                                                                         
    Natural Death                                      2                                                                            
    Terminal Sacrifice                                56           18           39           37           65                        
  Special Control                                                  20                                                               
  Animals Examined Microscopically                    99           32           60           62          100                        
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (99)         (32)         (60)         (59)         (100)                     
      Adenocarcinoma, Metastatic, Intestine Large                                                          1 (1%)                   
   Intestine Large, Colon                             (99)         (32)         (60)         (59)         (100)                     
      Adenocarcinoma                                                                                       1 (1%)                   
   Intestine Small, Duodenum                          (99)         (32)         (60)         (59)         (100)                     
      Polyp Adenomatous                                                                       2 (3%)       1 (1%)                   
   Intestine Small, Ileum                             (98)         (32)         (60)         (58)         (100)                     
      Adenocarcinoma, Metastatic, Intestine Large                                                          1 (1%)                   
   Intestine Small, Jejunum                           (99)         (32)         (60)         (59)         (100)                     
      Adenocarcinoma                                                             1 (2%)       1 (2%)                                
   Liver                                              (99)         (32)         (60)         (61)         (100)                     
      Adenocarcinoma, Metastatic, Stomach                                                     1 (2%)                                
      Fibrosarcoma, Metastatic, Prostate                                         1 (2%)                                             
      Hemangiosarcoma                                  3 (3%)       1 (3%)                    2 (3%)       2 (2%)                   
      Hemangiosarcoma, Multiple                        1 (1%)                    1 (2%)                    1 (1%)                   
      Hemangiosarcoma, Multiple, Metastatic, Liver                  1 (3%)                                                          
      Hemangiosarcoma, Metastatic, Heart                                         1 (2%)                                             
      Hemangiosarcoma, Metastatic, Spleen                                                                  1 (1%)                   
      Hepatoblastoma                                                             1 (2%)       1 (2%)       3 (3%)                   
      Hepatocellular Carcinoma                        19 (19%)      7 (22%)     11 (18%)     14 (23%)     13 (13%)                  
      Hepatocellular Carcinoma, Multiple               6 (6%)                    4 (7%)                    2 (2%)                   
      Hepatocellular Adenoma                          16 (16%)      8 (25%)     20 (33%)      5 (8%)      28 (28%)                  
      Hepatocellular Adenoma, Multiple                38 (38%)      7 (22%)     19 (32%)     27 (44%)     30 (30%)                  
      Histiocytic Sarcoma                                           1 (3%)                    1 (2%)       1 (1%)                   
   Mesentery                                          (10)         (2)          (5)          (8)          (4)                       
      Adenocarcinoma, Metastatic, Intestine Large                                                          1 (25%)                  
      Fibrosarcoma, Metastatic, Prostate                                         1 (20%)                                            
      Hepatocellular Carcinoma, Metastatic, Liver                                             1 (13%)                               
      Histiocytic Sarcoma                                           1 (50%)                                                         
                                                             Page   9                                                               
NTP Experiment-Test: 05131-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 09/17/94  
Route: DOSED WATER                                                                                                Time: 08:28:02  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                           0 PPM       SPECIAL       25 PPM       100 PPM      175 PPM                     
                                                                CONTROL                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - cont                                                                                                            
   Pancreas                                           (98)         (32)         (60)         (60)         (100)                     
      Fibrosarcoma, Metastatic, Prostate                                         1 (2%)                                             
      Hemangioma                                                                 1 (2%)                                             
   Salivary Glands                                    (98)         (32)         (60)         (60)         (100)                     
      Histiocytic Sarcoma                                                                     1 (2%)                                
   Stomach, Forestomach                               (99)         (32)         (60)         (60)         (99)                      
      Squamous Cell Papilloma                                       2 (6%)                                 1 (1%)                   
   Stomach, Glandular                                 (99)         (32)         (60)         (60)         (100)                     
      Adenocarcinoma                                                                          1 (2%)                                
      Adenoma                                                                    1 (2%)                                             
      Fibrosarcoma, Metastatic, Prostate                                         1 (2%)                                             
   Tooth                                              (90)         (32)         (60)         (60)         (90)                      
      Incisor, Odontoma                                                          1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (3)                       (1)          (1)          (2)                       
      Aorta, Alveolar/Bronchiolar Carcinoma,                                                                                        
          Metastatic, Lung                                                                                 1 (50%)                  
   Heart                                              (99)         (32)         (60)         (59)         (100)                     
      Hemangiosarcoma                                                            1 (2%)                                             
      Hemangiosarcoma, Metastatic, Liver               1 (1%)                                                                       
      Hemangiosarcoma, Metastatic, Skin                1 (1%)                                                                       
      Hemangiosarcoma, Metastatic, Spleen                                                                  1 (1%)                   
      Hepatoblastoma, Metastatic, Liver                                                                    1 (1%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (99)         (32)         (60)         (60)         (100)                     
      Adenoma                                          1 (1%)                                                                       
      Bilateral, Capsule, Spindle Cell, Adenoma        2 (2%)       1 (3%)       1 (2%)       1 (2%)                                
      Capsule, Spindle Cell, Adenoma                   6 (6%)                    6 (10%)      5 (8%)       6 (6%)                   
      Capsule, Spindle Cell, Adenoma, Multiple                                   1 (2%)                                             
   Adrenal Gland, Medulla                             (96)         (32)         (60)         (60)         (99)                      
      Pheochromocytoma Malignant                                                 1 (2%)                                             
      Pheochromocytoma Benign                                                    1 (2%)                    1 (1%)                   
   Islets, Pancreatic                                 (98)         (32)         (60)         (60)         (100)                     
      Adenoma                                                                                              2 (2%)                   
   Thyroid Gland                                      (99)         (32)         (60)         (60)         (100)                     
      C-Cell, Adenoma                                  1 (1%)                                                                       
      Follicular Cell, Adenoma                         1 (1%)       1 (3%)       1 (2%)       3 (5%)       2 (2%)                   
____________________________________________________________________________________________________________________________________
                                                             Page  10                                                               
NTP Experiment-Test: 05131-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 09/17/94  
Route: DOSED WATER                                                                                                Time: 08:28:02  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                           0 PPM       SPECIAL       25 PPM       100 PPM      175 PPM                     
                                                                CONTROL                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (99)         (32)         (60)         (60)         (99)                      
      Hepatocellular Carcinoma, Metastatic, Liver                                             1 (2%)                                
      Histiocytic Sarcoma                                                                                  1 (1%)                   
   Prostate                                           (99)         (32)         (60)         (60)         (99)                      
      Fibrosarcoma                                                               1 (2%)                                             
   Seminal Vesicle                                    (99)         (32)         (60)         (60)         (100)                     
      Fibrosarcoma, Metastatic, Prostate                                         1 (2%)                                             
      Hepatocellular Carcinoma, Metastatic, Liver                                             1 (2%)                                
   Testes                                             (98)         (31)         (60)         (60)         (99)                      
      Interstitial Cell, Adenoma                                                 1 (2%)                    1 (1%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Blood                                              (2)                                                                           
   Bone Marrow                                        (99)         (32)         (60)         (60)         (100)                     
      Femoral, Hemangiosarcoma                                                   1 (2%)       1 (2%)                                
      Femoral, Hemangiosarcoma, Metastatic, Liver                                                          1 (1%)                   
      Femoral, Hemangiosarcoma, Metastatic, Skin       1 (1%)       1 (3%)                                                          
      Femoral, Hemangiosarcoma, Metastatic, Spleen                                                         1 (1%)                   
      Femoral, Histiocytic Sarcoma                                                                         1 (1%)                   
      Humerus, Hemangiosarcoma                                                   2 (3%)                                             
      Humerus, Hemangiosarcoma, Metastatic, Skin       1 (1%)                                                                       
      Tibia, Hemangiosarcoma, Metastatic, Skin         1 (1%)                                                                       
   Lymph Node                                         (99)         (32)         (60)         (60)         (100)                     
      Bronchial, Alveolar/Bronchiolar Carcinoma,                                                                                    
           Metastatic, Lung                                                                                1 (1%)                   
      Mediastinal, Alveolar/Bronchiolar Carcinoma,                                                                                  
           Metastatic, Lung                                                      1 (2%)                                             
      Mediastinal, Fibrosarcoma, Metastatic,                                                                                        
          Prostate                                                               1 (2%)                                             
      Mediastinal, Hepatoblastoma, Metastatic,                                                                                      
           Liver                                                                                           1 (1%)                   
      Mediastinal, Hepatocellular Carcinoma,                                                                                        
          Metastatic, Liver                                                                   1 (2%)                                
      Pancreatic, Hepatoblastoma, Metastatic, Liver                                                        1 (1%)                   
      Renal, Hepatoblastoma, Metastatic, Liver                                                             1 (1%)                   
   Lymph Node, Mandibular                             (98)         (31)         (60)         (59)         (100)                     
   Lymph Node, Mesenteric                             (94)         (31)         (59)         (56)         (92)                      
      Adenocarcinoma, Metastatic, Intestine Large                                                          1 (1%)                   
                                                             Page  11                                                               
NTP Experiment-Test: 05131-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 09/17/94  
Route: DOSED WATER                                                                                                Time: 08:28:02  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                           0 PPM       SPECIAL       25 PPM       100 PPM      175 PPM                     
                                                                CONTROL                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - cont                                                                                                         
      Hepatocellular Carcinoma, Metastatic, Liver                                             1 (2%)                                
      Histiocytic Sarcoma                                                                     1 (2%)                                
   Spleen                                             (99)         (32)         (60)         (60)         (100)                     
      Hemangiosarcoma                                                                         1 (2%)       1 (1%)                   
      Hemangiosarcoma, Metastatic, Liver                                                                   1 (1%)                   
      Hemangiosarcoma, Metastatic, Skin                1 (1%)                                                                       
      Hepatocellular Carcinoma, Metastatic, Liver                                             1 (2%)                                
      Histiocytic Sarcoma                              1 (1%)       1 (3%)                    1 (2%)                                
   Thymus                                             (87)         (28)         (52)         (45)         (85)                      
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                                                  1 (2%)                                             
      Hepatoblastoma, Metastatic, Liver                                                                    1 (1%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (99)         (31)         (60)         (60)         (100)                     
      Hepatocellular Carcinoma, Metastatic, Liver                                             1 (2%)                                
      Squamous Cell Papilloma                                                                              1 (1%)                   
      Subcutaneous Tissue, Fibrosarcoma                             1 (3%)                                                          
      Subcutaneous Tissue, Hemangiosarcoma             1 (1%)       1 (3%)       1 (2%)                    2 (2%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (89)         (32)         (60)         (60)         (90)                      
      Cranium, Schwannoma Malignant, Metastatic,                                                                                    
           Brain                                                                                           1 (1%)                   
      Femur, Osteosarcoma                                                        1 (2%)                                             
      Humerus, Hemangiosarcoma                                                   1 (2%)                                             
      Maxilla, Adenocarcinoma, Metastatic,                                                                                          
          Harderian Gland                                                        1 (2%)                                             
   Skeletal Muscle                                    (11)                                                (11)                      
      Hepatoblastoma, Metastatic, Liver                                                                    1 (9%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (99)         (32)         (60)         (60)         (99)                      
      Olfactory Lobe, Schwannoma Malignant                                                                 1 (1%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page  12                                                               
NTP Experiment-Test: 05131-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 09/17/94  
Route: DOSED WATER                                                                                                Time: 08:28:02  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                           0 PPM       SPECIAL       25 PPM       100 PPM      175 PPM                     
                                                                CONTROL                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (99)         (32)         (60)         (60)         (100)                     
      Adenocarcinoma, Metastatic, Harderian Gland                                1 (2%)                                             
      Alveolar/Bronchiolar Adenoma                    10 (10%)      1 (3%)       4 (7%)      13 (22%)      9 (9%)                   
      Alveolar/Bronchiolar Adenoma, Multiple           2 (2%)                                              2 (2%)                   
      Alveolar/Bronchiolar Carcinoma                  12 (12%)      4 (13%)      8 (13%)      1 (2%)       7 (7%)                   
      Alveolar/Bronchiolar Carcinoma, Multiple                                   1 (2%)                                             
      Alveolar/Bronchiolar Carcinoma, Metastatic,                                                                                   
           Lung                                        2 (2%)       1 (3%)                    1 (2%)       2 (2%)                   
      Fibrosarcoma, Metastatic, Skin                                1 (3%)                                                          
      Hemangiosarcoma, Metastatic, Liver                                                                   1 (1%)                   
      Hepatoblastoma, Metastatic, Liver                                                                    1 (1%)                   
      Hepatocellular Carcinoma, Metastatic, Liver      8 (8%)       2 (6%)       2 (3%)       1 (2%)       1 (1%)                   
      Histiocytic Sarcoma                                           1 (3%)                                                          
      Lipoma                                                                     1 (2%)                                             
      Mediastinum, Alveolar/Bronchiolar Carcinoma,                                                                                  
           Metastatic, Lung                                                                                1 (1%)                   
      Mediastinum, Fibrosarcoma, Metastatic,                                                                                        
          Prostate                                                               1 (2%)                                             
   Nose                                               (99)         (32)         (60)         (60)         (100)                     
      Adenocarcinoma, Metastatic, Harderian Gland                                1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                (1)          (1)                       (2)          (1)                       
      Fibrosarcoma                                                                            1 (50%)      1 (100%)                 
   Harderian Gland                                    (85)         (27)         (49)         (52)         (75)                      
      Adenocarcinoma                                   1 (1%)                    1 (2%)                    1 (1%)                   
      Adenoma                                          7 (8%)                    2 (4%)                    2 (3%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (99)         (32)         (60)         (60)         (100)                     
      Hepatoblastoma, Metastatic, Liver                                                                    1 (1%)                   
      Hepatocellular Carcinoma, Metastatic, Liver                                             1 (2%)                                
      Histiocytic Sarcoma                                           1 (3%)                    1 (2%)                                
   Ureter                                                                       (1)                                                 
      Transitional Epithelium, Carcinoma                                         1 (100%)                                           
   Urinary Bladder                                    (98)         (32)         (60)         (59)         (100)                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(99)        *(32)        *(60)        *(62)        *(100)                     
      Histiocytic Sarcoma                              1 (1%)       1 (3%)                    2 (3%)       2 (2%)                   
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  13                                                               
NTP Experiment-Test: 05131-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 09/17/94  
Route: DOSED WATER                                                                                                Time: 08:28:02  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                           0 PPM       SPECIAL       25 PPM       100 PPM      175 PPM                     
                                                                CONTROL                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SYSTEMIC LESIONS - cont                                                                                                            
   Multiple Organs                                   *(99)        *(32)        *(60)        *(62)        *(100)                     
      Lymphoma Malignant Lymphocytic                   2 (2%)       1 (3%)                                                          
      Lymphoma Malignant Mixed                         1 (1%)                    1 (2%)       3 (5%)                                
      Lymphoma Malignant Undifferentiated Cell         1 (1%)                                 3 (5%)       1 (1%)                   
____________________________________________________________________________________________________________________________________
                                                             Page  14                                                               
NTP Experiment-Test: 05131-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 09/17/94  
Route: DOSED WATER                                                                                                Time: 08:28:02  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                           0 PPM       SPECIAL       25 PPM       100 PPM      175 PPM                     
                                                                CONTROL                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            77          24          51          47          74                           
     Total Primary Neoplasms                          132          36          99          87         124                           
                                                                                                                                    
   Total Animals with Benign Neoplasms                 62          17          45          38          62                           
     Total Benign Neoplasms                            84          20          60          56          86                           
                                                                                                                                    
   Total Animals with Malignant Neoplasms              43          14          32          26          33                           
     Total Malignant Neoplasms                         48          16          39          31          38                           
                                                                                                                                    
   Total Animals with Metastatic Neoplasms             12           6           6           3           8                           
     Total Metastatic Neoplasm                         16           6          15          11          25                           
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  15                                                               
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                             ----------              END OF REPORT             ----------                                           
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