National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/2254

TR 393 Mouse Pathology Tables

NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11 
LAB: Battelle Columbus                                         DATE: 09/17/94   
EXP: 05131                     SODIUM FLUORIDE                 TIME: 08:51:14   
TEST: 02              CAGES FROM 0000 TO LAST CAGE             PAGE:   1        
TEST TYPE: CHRONIC          ROUTE: DOSED WATER                 NTP C#: 55221B   
CONT: N01-ES-55102                                             CAS: 7681-49-4   
PATHOLOGIST: J. TOFT                         S. EUSTIS                          
--------------------------------------------------------------------------------
                                                                                
                                                                                
                                                                                


REASONS FOR REMOVAL:                                                            
                                                                                
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NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11
LAB: Battelle Columbus                                         DATE: 09/17/94  
EXP: 05131                     SODIUM FLUORIDE                 TIME: 08:51:14  
TEST: 02              CAGES FROM 0000 TO LAST CAGE                             
TEST TYPE: CHRONIC          ROUTE: DOSED WATER                 NTP C#: 55221B  
CONT: N01-ES-55102                                             CAS: 7681-49-4  
PATHOLOGIST: J. TOFT                         S. EUSTIS                         

                                  SODIUM FLUORIDE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 729 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 0 PPM                                    |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 99     UNCENSORED DEATHS 21     CENSORED DEATHS 20   TERMINAL 58        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      420   496   571   578   591   625   626   641   645   662                 |
 |      669   684   691   696   698   701   704   715   720   721                 |
 |      721                                                                       |
 |  CENSORED DEATHS                                                               |
 |      165   165   165   165   165   165   166   166   166   166                 |
 |      458   458   458   458   458   458   459   459   459   459                 |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = SPECIAL CONTROL                                |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 12     CENSORED DEATHS 20   TERMINAL 18        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      359   420   433   505   519   523   530   564   609   657                 |
 |      687   713                                                                 |
 |  CENSORED DEATHS                                                               |
 |      17    208   241   273   386   420   488   527   540   568                 |
 |      579   593   599   619   623   651   660   684   698   706                 |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 25 PPM                                   |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 70     UNCENSORED DEATHS 11     CENSORED DEATHS 20   TERMINAL 39        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      208   540   619   624   629   656   657   684   707   709                 |
 |      728                                                                       |
 |  CENSORED DEATHS                                                               |
 |      165   165   165   165   165   165   166   166   166   166                 |
 |      458   458   458   458   458   458   459   459   459   459                 |
 |                                                                                |
 ==================================================================================

                                  SODIUM FLUORIDE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 729 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 100 PPM                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 70     UNCENSORED DEATHS 14     CENSORED DEATHS 19   TERMINAL 37        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      17    241   505   528   568   579   598   619   620   626                 |
 |      651   660   692   721                                                     |
 |  CENSORED DEATHS                                                               |
 |      165   165   165   165   166   166   166   166   166   166                 |
 |      458   458   459   459   459   459   459   459   459                       |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 175 PPM                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 100    UNCENSORED DEATHS 15     CENSORED DEATHS 20   TERMINAL 65        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      273   386   488   527   529   593   609   623   684   691                 |
 |      705   714   714   719   721                                               |
 |  CENSORED DEATHS                                                               |
 |      165   165   165   165   166   166   166   166   166   166                 |
 |      458   458   458   458   458   459   459   459   459   459                 |
 |                                                                                |
 ==================================================================================

                                  SODIUM FLUORIDE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 729 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   729 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |0 PPM      |   100.0 100.0 100.0 100.0  98.9  98.9  97.6  93.8  87.5  73.5      |
 |           |                                                                    |
 |           |                                                                    |
 |SPECIAL    |   100.0 100.0 100.0  97.8  95.6  93.3  83.9  81.5  75.5  68.3      |
 |CONTROL    |                                                                    |
 |           |                                                                    |
 |25 PPM     |   100.0 100.0  98.3  98.3  98.3  98.3  96.3  96.3  86.3  78.3      |
 |           |                                                                    |
 |           |                                                                    |
 |100 PPM    |    98.6  98.6  96.9  96.9  96.9  96.9  92.9  87.0  77.1  73.2      |
 |           |                                                                    |
 |           |                                                                    |
 |175 PPM    |   100.0 100.0 100.0  98.9  97.8  97.8  94.0  92.8  90.3  81.5      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================

                                  SODIUM FLUORIDE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 729 DAYS


 ===============================================================================================================================
 |                                               SURVIVAL SUMMARY STATISTICS                                                   |
 |                                                                                                                             |
 |                                                                                                                             |
 |-----------------------------------------------------------------------------------------------------------------------------|
 |                                                                           DOSE                                              |
 |                                                                                                                             |
 |                                0 PPM              SPECIAL            25 PPM             100 PPM            175 PPM          |
 |                                                   CONTROL                                                                   |
 |-----------------------------------------------------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       73.5%              68.3%              78.3%              73.2%              81.5%            |
 |(KAPLAN-MEIER)          |                                                                                                    |
 |                        |                                                                                                    |
 |SIGNIFICANCE (B)        |       P=0.218N            -----             P=0.709N           P=0.905            P=0.341N         |
 |(LIFE TABLE)            |                                                                                                    |
 |                        |                                                                                                    |
 |MEAN DAY OF             |       646.4              543.3              614.6              544.6              598.4            |
 |NATURAL DEATHS (C)      |       (17.3)             (31.5)             (43.7)             (50.9)             (35.0)           |
 |(STANDARD ERROR)        |                                                                                                    |
 |                        |                                                                                                    |
 |MEAN LIFE SPAN (D)      |       627.2              594.4              591.9              576.9              626.0            |
 |(STANDARD ERROR)        |       (18.0)             (23.3)             (24.7)             (25.6)             (18.4)           |
 |                        |                                                                                                    |
 ===============================================================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                                  SODIUM FLUORIDE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 729 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 0 PPM                                    |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 100    UNCENSORED DEATHS 27     CENSORED DEATHS 20   TERMINAL 53        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      358   420   489   518   528   562   592   592   602   610                 |
 |      620   632   637   644   652   657   662   670   676   691                 |
 |      704   713   715   715   722   722   722                                   |
 |  CENSORED DEATHS                                                               |
 |      165   165   165   166   166   166   166   166   166   166                 |
 |      458   458   458   458   458   458   459   459   459   459                 |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                          DOSE = SPECIAL CONTROL                                |
 |                       ----------------------------                             |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 13     CENSORED DEATHS 29   TERMINAL 8         |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      259   349   437   456   500   571   579   603   631   666                 |
 |      676   680   713                                                           |
 |  CENSORED DEATHS                                                               |
 |      135   179   198   241   278   286   313   349   361   379                 |
 |      395   411   420   433   477   478   527   534   552   566                 |
 |      568   587   611   617   648   652   691   698   706                       |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 25 PPM                                   |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 70     UNCENSORED DEATHS 14     CENSORED DEATHS 18   TERMINAL 38        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      198   395   534   534   584   587   617   624   636   648                 |
 |      652   670   678   698                                                     |
 |  CENSORED DEATHS                                                               |
 |      165   165   165   165   165   166   166   166   166   166                 |
 |      458   458   458   458   458   459   459   459                             |
 |                                                                                |
 ==================================================================================

                                  SODIUM FLUORIDE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 729 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = 100 PPM                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 70     UNCENSORED DEATHS 16     CENSORED DEATHS 20   TERMINAL 34        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      313   379   411   478   527   552   587   611   617   634                 |
 |      653   657   684   692   724   724                                         |
 |  CENSORED DEATHS                                                               |
 |      165   165   165   165   165   165   165   166   166   166                 |
 |      458   458   458   458   459   459   459   459   459   459                 |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 175 PPM                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 99     UNCENSORED DEATHS 28     CENSORED DEATHS 19   TERMINAL 52        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      135   179   241   278   286   314   349   361   433   477                 |
 |      500   566   568   573   579   584   606   610   619   632                 |
 |      666   684   688   705   707   709   712   715                             |
 |  CENSORED DEATHS                                                               |
 |      165   165   165   165   165   166   166   166   166   166                 |
 |      458   458   458   458   459   459   459   459   459                       |
 |                                                                                |
 ==================================================================================

                                  SODIUM FLUORIDE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 729 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   729 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |0 PPM      |   100.0 100.0 100.0  98.9  97.8  97.8  94.0  89.0  79.0  66.4      |
 |           |                                                                    |
 |           |                                                                    |
 |SPECIAL    |   100.0 100.0  97.8  95.5  95.5  89.9  86.9  75.9  71.6  50.9      |
 |CONTROL    |                                                                    |
 |           |                                                                    |
 |25 PPM     |   100.0 100.0  98.3  98.3  96.7  96.7  92.8  88.9  79.3  73.5      |
 |           |                                                                    |
 |           |                                                                    |
 |100 PPM    |   100.0 100.0 100.0  98.3  95.0  93.0  91.0  86.9  76.8  68.7      |
 |           |                                                                    |
 |           |                                                                    |
 |175 PPM    |   100.0  97.9  96.7  91.1  91.1  88.7  87.5  81.1  76.0  65.9      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================

                                  SODIUM FLUORIDE


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 729 DAYS


 ===============================================================================================================================
 |                                               SURVIVAL SUMMARY STATISTICS                                                   |
 |                                                                                                                             |
 |                                                                                                                             |
 |-----------------------------------------------------------------------------------------------------------------------------|
 |                                                                           DOSE                                              |
 |                                                                                                                             |
 |                                0 PPM              SPECIAL            25 PPM             100 PPM            175 PPM          |
 |                                                   CONTROL                                                                   |
 |-----------------------------------------------------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       66.4%              50.9%              73.5%              68.7%              65.9%            |
 |(KAPLAN-MEIER)          |                                                                                                    |
 |                        |                                                                                                    |
 |SIGNIFICANCE (B)        |       P=0.897             -----             P=0.602N           P=1.000N           P=0.751          |
 |(LIFE TABLE)            |                                                                                                    |
 |                        |                                                                                                    |
 |MEAN DAY OF             |       623.1              547.7              575.4              577.7              517.0            |
 |NATURAL DEATHS (C)      |       (18.1)             (38.6)             (35.7)             (31.3)             (33.9)           |
 |(STANDARD ERROR)        |                                                                                                    |
 |                        |                                                                                                    |
 |MEAN LIFE SPAN (D)      |       617.0              524.8              586.8              575.3              587.5            |
 |(STANDARD ERROR)        |       (17.9)             (24.5)             (24.5)             (24.3)             (20.3)           |
 |                        |                                                                                                    |
 ===============================================================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                                                          SODIUM FLUORIDE
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        0 PPM            = 1
                                                        SPECIAL CONTROL  = 2
                                                        25 PPM           = 3
                                                        100 PPM          = 4
                                                        175 PPM          = 5

------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  100 + 1  4                             3         5             2        1
      |    4                             3     4   5                  5   1           1       3
      |                                        4                 2    5   2          51 4         1
      |                                                                              5      5 3   11      3
   95 +                                                                   2 2           4   4      1  1
      |                                                                     2           2   5         1   31
P     |                                                                                     4     4   5 5
E     |                                                                                 2  2      44    5 51 1
R  90 +                                                                                                   53 113    5
C     |                                                                                            4   4      1  1  55
E     |                                                                                                4  4      11  5 5
N     |                                                                                    22                  3  1 1  55
T  85 +                                                                                                             11
      |                                                                                     2    2                  311355
S     |                                                                                                   44           33
U     |                                                                                          2      2  4  4       11 5  5
R  80 +                                                                                                                 3 3
V     |                                                                                                 2     42 4     1 13 3
I     |                                                                                                          4   4
V     |
A  75 +                                                                                                        2     2   4
L     |                                                                                                                  1  1
      |                                                                                                              2  2
      |
   70 +
      |                                                                                                                 2   2
      |
      |
   65 +
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 10 obs hidden.

                                                          SODIUM FLUORIDE
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        0 PPM            = 1
                                                        SPECIAL CONTROL  = 2
                                                        25 PPM           = 3
                                                        100 PPM          = 4
                                                        175 PPM          = 5

----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
  100 + 1                     5         3        2        4      1
      |                       5      5  3                 4      1   4 3  1
      |                              5         5 2             2          1          1
      |                                        5    5                4 3 4           1   1   3
   95 +                                             55    5    2         4   2      4    1  1
      |                                                   5    5                            1    1
      |                                                        5 5           2   2  4       43   1  3 1
      |                                                          5          5               4  4
   90 +                                                                     5    2  5  2              11
      |                                                                             5  5       4    3  1 13
      |                                                                                2         52 4    113
      |                                                                                          55       1 1
P  85 +                                                                                                  4433
E     |                                                                                           22        113
R     |                                                                                            55     4 41 1
C     |                                                                                             5   5   4 33
E  80 +                                                                                            2    25     1 1
N     |                                                                                                  55    3 11
T     |                                                                                                   5 5     11
      |                                                                                                 2   2  4  5141
S  75 +                                                                                                           534131
U     |                                                                                                             55311   3
R     |                                                                                                              4 5114
V     |                                                                                                     2     2
I  70 +                                                                                                                5511
V     |                                                                                                                   4 4
A     |                                                                                                                 55
L     |                                                                                                           22     51 1
   65 +
      |
      |                                                                                                            22
      |
   60 +
      |
      |                                                                                                             2   2
      |
   55 +
      |
      |
      |                                                                                                                 2   2
   50 +
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 22 obs hidden.

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