TR 393 Mouse Pathology Tables
NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Columbus DATE: 09/17/94
EXP: 05131 SODIUM FLUORIDE TIME: 08:51:14
TEST: 02 CAGES FROM 0000 TO LAST CAGE PAGE: 1
TEST TYPE: CHRONIC ROUTE: DOSED WATER NTP C#: 55221B
CONT: N01-ES-55102 CAS: 7681-49-4
PATHOLOGIST: J. TOFT S. EUSTIS
--------------------------------------------------------------------------------
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NTP STATISTICAL ANALYSIS OF SURVIVAL DATA REPORT: PEIRPT11
LAB: Battelle Columbus DATE: 09/17/94
EXP: 05131 SODIUM FLUORIDE TIME: 08:51:14
TEST: 02 CAGES FROM 0000 TO LAST CAGE
TEST TYPE: CHRONIC ROUTE: DOSED WATER NTP C#: 55221B
CONT: N01-ES-55102 CAS: 7681-49-4
PATHOLOGIST: J. TOFT S. EUSTIS
SODIUM FLUORIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 PPM |
| --------------------- |
| |
| TOTAL 99 UNCENSORED DEATHS 21 CENSORED DEATHS 20 TERMINAL 58 |
| |
| UNCENSORED DEATHS |
| 420 496 571 578 591 625 626 641 645 662 |
| 669 684 691 696 698 701 704 715 720 721 |
| 721 |
| CENSORED DEATHS |
| 165 165 165 165 165 165 166 166 166 166 |
| 458 458 458 458 458 458 459 459 459 459 |
| |
|--------------------------------------------------------------------------------|
| DOSE = SPECIAL CONTROL |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 12 CENSORED DEATHS 20 TERMINAL 18 |
| |
| UNCENSORED DEATHS |
| 359 420 433 505 519 523 530 564 609 657 |
| 687 713 |
| CENSORED DEATHS |
| 17 208 241 273 386 420 488 527 540 568 |
| 579 593 599 619 623 651 660 684 698 706 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 25 PPM |
| --------------------- |
| |
| TOTAL 70 UNCENSORED DEATHS 11 CENSORED DEATHS 20 TERMINAL 39 |
| |
| UNCENSORED DEATHS |
| 208 540 619 624 629 656 657 684 707 709 |
| 728 |
| CENSORED DEATHS |
| 165 165 165 165 165 165 166 166 166 166 |
| 458 458 458 458 458 458 459 459 459 459 |
| |
==================================================================================
SODIUM FLUORIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 100 PPM |
| --------------------- |
| |
| TOTAL 70 UNCENSORED DEATHS 14 CENSORED DEATHS 19 TERMINAL 37 |
| |
| UNCENSORED DEATHS |
| 17 241 505 528 568 579 598 619 620 626 |
| 651 660 692 721 |
| CENSORED DEATHS |
| 165 165 165 165 166 166 166 166 166 166 |
| 458 458 459 459 459 459 459 459 459 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 175 PPM |
| --------------------- |
| |
| TOTAL 100 UNCENSORED DEATHS 15 CENSORED DEATHS 20 TERMINAL 65 |
| |
| UNCENSORED DEATHS |
| 273 386 488 527 529 593 609 623 684 691 |
| 705 714 714 719 721 |
| CENSORED DEATHS |
| 165 165 165 165 166 166 166 166 166 166 |
| 458 458 458 458 458 459 459 459 459 459 |
| |
==================================================================================
SODIUM FLUORIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 PPM | 100.0 100.0 100.0 100.0 98.9 98.9 97.6 93.8 87.5 73.5 |
| | |
| | |
|SPECIAL | 100.0 100.0 100.0 97.8 95.6 93.3 83.9 81.5 75.5 68.3 |
|CONTROL | |
| | |
|25 PPM | 100.0 100.0 98.3 98.3 98.3 98.3 96.3 96.3 86.3 78.3 |
| | |
| | |
|100 PPM | 98.6 98.6 96.9 96.9 96.9 96.9 92.9 87.0 77.1 73.2 |
| | |
| | |
|175 PPM | 100.0 100.0 100.0 98.9 97.8 97.8 94.0 92.8 90.3 81.5 |
| | |
| | |
==================================================================================
SODIUM FLUORIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
MALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
===============================================================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|-----------------------------------------------------------------------------------------------------------------------------|
| DOSE |
| |
| 0 PPM SPECIAL 25 PPM 100 PPM 175 PPM |
| CONTROL |
|-----------------------------------------------------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 73.5% 68.3% 78.3% 73.2% 81.5% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.218N ----- P=0.709N P=0.905 P=0.341N |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 646.4 543.3 614.6 544.6 598.4 |
|NATURAL DEATHS (C) | (17.3) (31.5) (43.7) (50.9) (35.0) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 627.2 594.4 591.9 576.9 626.0 |
|(STANDARD ERROR) | (18.0) (23.3) (24.7) (25.6) (18.4) |
| | |
===============================================================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
SODIUM FLUORIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 0 PPM |
| --------------------- |
| |
| TOTAL 100 UNCENSORED DEATHS 27 CENSORED DEATHS 20 TERMINAL 53 |
| |
| UNCENSORED DEATHS |
| 358 420 489 518 528 562 592 592 602 610 |
| 620 632 637 644 652 657 662 670 676 691 |
| 704 713 715 715 722 722 722 |
| CENSORED DEATHS |
| 165 165 165 166 166 166 166 166 166 166 |
| 458 458 458 458 458 458 459 459 459 459 |
| |
|--------------------------------------------------------------------------------|
| DOSE = SPECIAL CONTROL |
| ---------------------------- |
| |
| TOTAL 50 UNCENSORED DEATHS 13 CENSORED DEATHS 29 TERMINAL 8 |
| |
| UNCENSORED DEATHS |
| 259 349 437 456 500 571 579 603 631 666 |
| 676 680 713 |
| CENSORED DEATHS |
| 135 179 198 241 278 286 313 349 361 379 |
| 395 411 420 433 477 478 527 534 552 566 |
| 568 587 611 617 648 652 691 698 706 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 25 PPM |
| --------------------- |
| |
| TOTAL 70 UNCENSORED DEATHS 14 CENSORED DEATHS 18 TERMINAL 38 |
| |
| UNCENSORED DEATHS |
| 198 395 534 534 584 587 617 624 636 648 |
| 652 670 678 698 |
| CENSORED DEATHS |
| 165 165 165 165 165 166 166 166 166 166 |
| 458 458 458 458 458 459 459 459 |
| |
==================================================================================
SODIUM FLUORIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
INDIVIDUAL SURVIVAL TIMES (DAYS)
==================================================================================
| DOSE = 100 PPM |
| --------------------- |
| |
| TOTAL 70 UNCENSORED DEATHS 16 CENSORED DEATHS 20 TERMINAL 34 |
| |
| UNCENSORED DEATHS |
| 313 379 411 478 527 552 587 611 617 634 |
| 653 657 684 692 724 724 |
| CENSORED DEATHS |
| 165 165 165 165 165 165 165 166 166 166 |
| 458 458 458 458 459 459 459 459 459 459 |
| |
|--------------------------------------------------------------------------------|
| DOSE = 175 PPM |
| --------------------- |
| |
| TOTAL 99 UNCENSORED DEATHS 28 CENSORED DEATHS 19 TERMINAL 52 |
| |
| UNCENSORED DEATHS |
| 135 179 241 278 286 314 349 361 433 477 |
| 500 566 568 573 579 584 606 610 619 632 |
| 666 684 688 705 707 709 712 715 |
| CENSORED DEATHS |
| 165 165 165 165 165 166 166 166 166 166 |
| 458 458 458 458 459 459 459 459 459 |
| |
==================================================================================
SODIUM FLUORIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
==================================================================================
| KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%) |
| |
|--------------------------------------------------------------------------------|
| DOSE TIME (DAYS) |
| 90 180 270 365 425 485 545 605 665 729 (A) |
| |
|--------------------------------------------------------------------------------|
| | |
|0 PPM | 100.0 100.0 100.0 98.9 97.8 97.8 94.0 89.0 79.0 66.4 |
| | |
| | |
|SPECIAL | 100.0 100.0 97.8 95.5 95.5 89.9 86.9 75.9 71.6 50.9 |
|CONTROL | |
| | |
|25 PPM | 100.0 100.0 98.3 98.3 96.7 96.7 92.8 88.9 79.3 73.5 |
| | |
| | |
|100 PPM | 100.0 100.0 100.0 98.3 95.0 93.0 91.0 86.9 76.8 68.7 |
| | |
| | |
|175 PPM | 100.0 97.9 96.7 91.1 91.1 88.7 87.5 81.1 76.0 65.9 |
| | |
| | |
==================================================================================
SODIUM FLUORIDE
STATISTICAL ANALYSIS OF SURVIVAL DATA
FEMALE MICE
FIRST TERMINAL SACRIFICE AT 729 DAYS
===============================================================================================================================
| SURVIVAL SUMMARY STATISTICS |
| |
| |
|-----------------------------------------------------------------------------------------------------------------------------|
| DOSE |
| |
| 0 PPM SPECIAL 25 PPM 100 PPM 175 PPM |
| CONTROL |
|-----------------------------------------------------------------------------------------------------------------------------|
|SURVIVAL AT END OF STUDY| 66.4% 50.9% 73.5% 68.7% 65.9% |
|(KAPLAN-MEIER) | |
| | |
|SIGNIFICANCE (B) | P=0.897 ----- P=0.602N P=1.000N P=0.751 |
|(LIFE TABLE) | |
| | |
|MEAN DAY OF | 623.1 547.7 575.4 577.7 517.0 |
|NATURAL DEATHS (C) | (18.1) (38.6) (35.7) (31.3) (33.9) |
|(STANDARD ERROR) | |
| | |
|MEAN LIFE SPAN (D) | 617.0 524.8 586.8 575.3 587.5 |
|(STANDARD ERROR) | (17.9) (24.5) (24.5) (24.3) (20.3) |
| | |
===============================================================================================================================
(A) FIRST TERMINAL SACRIFICE
(B) THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
(COX,1972). NEGATIVE TRENDS ARE INDICATED BY "N".
(C) MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
(D) MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)
SODIUM FLUORIDE
KAPLAN-MEIER SURVIVAL CURVES
0 PPM = 1
SPECIAL CONTROL = 2
25 PPM = 3
100 PPM = 4
175 PPM = 5
------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
|
100 + 1 4 3 5 2 1
| 4 3 4 5 5 1 1 3
| 4 2 5 2 51 4 1
| 5 5 3 11 3
95 + 2 2 4 4 1 1
| 2 2 5 1 31
P | 4 4 5 5
E | 2 2 44 5 51 1
R 90 + 53 113 5
C | 4 4 1 1 55
E | 4 4 11 5 5
N | 22 3 1 1 55
T 85 + 11
| 2 2 311355
S | 44 33
U | 2 2 4 4 11 5 5
R 80 + 3 3
V | 2 42 4 1 13 3
I | 4 4
V |
A 75 + 2 2 4
L | 1 1
| 2 2
|
70 +
| 2 2
|
|
65 +
|
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 10 obs hidden.
SODIUM FLUORIDE
KAPLAN-MEIER SURVIVAL CURVES
0 PPM = 1
SPECIAL CONTROL = 2
25 PPM = 3
100 PPM = 4
175 PPM = 5
----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------
Plot of SURVIVAL*WEEK. Symbol is value of DOSE.
|
100 + 1 5 3 2 4 1
| 5 5 3 4 1 4 3 1
| 5 5 2 2 1 1
| 5 5 4 3 4 1 1 3
95 + 55 5 2 4 2 4 1 1
| 5 5 1 1
| 5 5 2 2 4 43 1 3 1
| 5 5 4 4
90 + 5 2 5 2 11
| 5 5 4 3 1 13
| 2 52 4 113
| 55 1 1
P 85 + 4433
E | 22 113
R | 55 4 41 1
C | 5 5 4 33
E 80 + 2 25 1 1
N | 55 3 11
T | 5 5 11
| 2 2 4 5141
S 75 + 534131
U | 55311 3
R | 4 5114
V | 2 2
I 70 + 5511
V | 4 4
A | 55
L | 22 51 1
65 +
|
| 22
|
60 +
|
| 2 2
|
55 +
|
|
| 2 2
50 +
--+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
0 10 20 30 40 50 60 70 80 90 100 110
WEEK
NOTE: 22 obs hidden.
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