National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/2256

TR 393 Rat Pathology Tables


                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                          SODIUM FLUORIDE


NTP Experiment-Test: 05131-01                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 09/17/94
Route: DOSED WATER                                                                                                Time: 03:55:26




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  7681-49-4

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05131-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 09/17/94  
Route: DOSED WATER                                                                                                Time: 03:55:26  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                    0 PPM       SPECIAL       25 PPM       100 PPM      175 PPM                     
                                                                CONTROL                                                             
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                         100           50           70           70          100                        
  Scheduled Sacrifice                                 20                        20           20           19                        
  Early Deaths                                                                                                                      
    Natural Death                                     10            4           11            6           10                        
    Moribund Sacrifice                                11            7            8           10           17                        
  Survivors                                                                                                                         
    Terminal Sacrifice                                59           18           31           34           54                        
  Special Control                                                  21                                                               
  Animals Examined Microscopically                   100           32           70           70          100                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Small, Duodenum                          (100)        (32)         (60)         (60)         (100)                     
      Necrosis                                                                   1 (2%)                                             
   Intestine Small, Jejunum                           (100)        (32)         (60)         (60)         (100)                     
      Inflammation, Chronic                                                      1 (2%)                                             
   Liver                                              (100)        (32)         (60)         (60)         (100)                     
      Angiectasis                                      1 (1%)                    1 (2%)                                             
      Basophilic Focus                                55 (55%)     13 (41%)     38 (63%)     33 (55%)     52 (52%)                  
      Clear Cell Focus                                13 (13%)      1 (3%)       8 (13%)      9 (15%)      8 (8%)                   
      Congestion                                       1 (1%)                    1 (2%)       2 (3%)                                
      Eosinophilic Focus                               4 (4%)       1 (3%)       6 (10%)      7 (12%)      9 (9%)                   
      Hepatodiaphragmatic Nodule                       8 (8%)       5 (16%)      8 (13%)     10 (17%)     15 (15%)                  
      Hepatodiaphragmatic Nodule, Multiple                                                    1 (2%)       1 (1%)                   
      Hyperplasia                                      1 (1%)                    2 (3%)       3 (5%)                                
      Inflammation, Chronic Active                    23 (23%)     11 (34%)     17 (28%)     16 (27%)     24 (24%)                  
      Mixed Cell Focus                                                                        1 (2%)       2 (2%)                   
      Vacuolization Cytoplasmic                       11 (11%)      6 (19%)      8 (13%)      7 (12%)     19 (19%)                  
      Bile Duct, Hyperplasia                          25 (25%)     12 (38%)     14 (23%)     18 (30%)     23 (23%)                  
      Centrilobular, Necrosis                          1 (1%)                    1 (2%)       1 (2%)                                
      Hepatocyte, Degeneration, Cystic                                                        1 (2%)                                
   Mesentery                                          (4)          (1)          (3)          (2)          (2)                       
      Inflammation, Chronic Active                     1 (25%)                                                                      
      Fat, Congestion, Acute                                                                  1 (50%)                               
      Fat, Inflammation, Chronic Active                3 (75%)                   2 (67%)                   2 (100%)                 
   Pancreas                                           (100)        (32)         (60)         (60)         (99)                      
      Acinus, Atrophy                                 21 (21%)      6 (19%)     10 (17%)      7 (12%)     21 (21%)                  
      Acinus, Cytomegaly, Focal                                                               1 (2%)                                
      Artery, Inflammation, Chronic Active             1 (1%)                                                                       
   Pharynx                                                                      (1)          (2)          (1)                       
      Hyperplasia, Squamous                                                                   1 (50%)                               
   Salivary Glands                                    (100)        (32)         (60)         (59)         (97)                      
      Acinus, Atrophy                                                                         1 (2%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05131-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 09/17/94  
Route: DOSED WATER                                                                                                Time: 03:55:26  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                    0 PPM       SPECIAL       25 PPM       100 PPM      175 PPM                     
                                                                CONTROL                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Acinus, Cytomegaly                               1 (1%)                                                                       
   Stomach, Forestomach                               (100)        (32)         (60)         (60)         (100)                     
      Acanthosis                                       4 (4%)       1 (3%)       3 (5%)       2 (3%)       3 (3%)                   
      Inflammation, Chronic Active                                                            1 (2%)       2 (2%)                   
      Ulcer                                            1 (1%)                    3 (5%)       3 (5%)       6 (6%)                   
   Stomach, Glandular                                 (100)        (32)         (60)         (60)         (100)                     
      Cyst Epithelial Inclusion                        1 (1%)                                                                       
      Erosion                                                                    1 (2%)                                             
      Hyperplasia                                      1 (1%)                                                                       
      Mineralization                                   1 (1%)                                                                       
      Necrosis                                         2 (2%)       2 (6%)       1 (2%)       1 (2%)       3 (3%)                   
      Pigmentation                                                               1 (2%)                                             
      Pigmentation, Hemosiderin                                                  1 (2%)       1 (2%)       1 (1%)                   
      Ulcer                                                         1 (3%)       1 (2%)       1 (2%)       3 (3%)                   
   Tongue                                             (1)                                    (1)          (1)                       
      Hyperplasia, Squamous                            1 (100%)                               1 (100%)     1 (100%)                 
   Tooth                                              (98)         (31)         (70)         (70)         (100)                     
      Dentine, Dentine, Incisor, Incisor, Necrosis,                                                                                 
           Multifocal, Multifocal                      1 (1%)                                                                       
      Dentine, Incisor, Dysplasia                                   2 (6%)       8 (11%)      4 (6%)      10 (10%)                  
      Dentine, Incisor, Necrosis, Focal                5 (5%)                                 4 (6%)       4 (4%)                   
      Dentine, Incisor, Necrosis, Multifocal          54 (55%)     16 (52%)     34 (49%)     26 (37%)     53 (53%)                  
      Incisor, Odontoblast, Degeneration                                                                   2 (2%)                   
      Incisor, Ameloblast, Degeneration                                                       1 (1%)       7 (7%)                   
      Peridontal Tissue, Incisor, Inflammation,                                                                                     
           Necrotizing                                 1 (1%)                                                                       
      Peridontal Tissue, Incisor, Lower,                                                                                            
          Inflammation, Chronic, Suppurative                                     1 (1%)                                             
      Peridontal Tissue, Molar, Inflammation,                                                                                       
          Suppurative                                  3 (3%)                    2 (3%)                    4 (4%)                   
      Peridontal Tissue, Molar, Lower,                                                                                              
          Inflammation, Chronic, Suppurative          20 (20%)      5 (16%)      7 (10%)     10 (14%)     21 (21%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (100)        (32)         (60)         (60)         (100)                     
      Degeneration, Chronic                           69 (69%)     18 (56%)     46 (77%)     43 (72%)     69 (69%)                  
      Inflammation, Chronic Active                                                                         1 (1%)                   
      Thrombosis                                                    1 (3%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05131-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 09/17/94  
Route: DOSED WATER                                                                                                Time: 03:55:26  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                    0 PPM       SPECIAL       25 PPM       100 PPM      175 PPM                     
                                                                CONTROL                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (100)        (32)         (60)         (60)         (100)                     
      Accessory Adrenal Cortical Nodule                1 (1%)                    1 (2%)                    1 (1%)                   
      Angiectasis                                                                1 (2%)                                             
      Congestion                                       1 (1%)                                                                       
      Degeneration, Cystic                             5 (5%)                    1 (2%)       1 (2%)       3 (3%)                   
      Hyperplasia                                     17 (17%)      2 (6%)      13 (22%)     18 (30%)     15 (15%)                  
      Hypertrophy                                      3 (3%)       1 (3%)       5 (8%)       5 (8%)      10 (10%)                  
      Necrosis                                                                   1 (2%)                                             
      Vacuolization Cytoplasmic, Focal                 7 (7%)                    1 (2%)       2 (3%)       7 (7%)                   
      Bilateral, Degeneration, Cystic                                                         1 (2%)                                
      Bilateral, Hyperplasia                           1 (1%)                                                                       
   Adrenal Gland, Medulla                             (100)        (32)         (59)         (60)         (100)                     
      Angiectasis                                                                1 (2%)                                             
      Cyst                                                                                                 1 (1%)                   
      Hemorrhage                                       1 (1%)                                                                       
      Hyperplasia                                      3 (3%)                    3 (5%)       8 (13%)      6 (6%)                   
      Hypertrophy                                                                             1 (2%)                                
   Islets, Pancreatic                                 (100)        (32)         (60)         (60)         (99)                      
      Hyperplasia                                                                                          1 (1%)                   
   Pituitary Gland                                    (99)         (32)         (60)         (60)         (100)                     
      Pars Distalis, Congestion                       21 (21%)      1 (3%)      12 (20%)     17 (28%)     22 (22%)                  
      Pars Distalis, Cyst                             20 (20%)      6 (19%)     23 (38%)     17 (28%)     30 (30%)                  
      Pars Distalis, Hemorrhage                        1 (1%)       1 (3%)       2 (3%)                    5 (5%)                   
      Pars Distalis, Hyperplasia                      21 (21%)      7 (22%)     13 (22%)     10 (17%)     19 (19%)                  
      Pars Intermedia, Congestion                                                1 (2%)                                             
      Pars Intermedia, Cyst                            2 (2%)                    1 (2%)                    4 (4%)                   
      Pars Intermedia, Hyperplasia                     1 (1%)                                 1 (2%)                                
      Rathke's Cleft, Cyst                             1 (1%)                                                                       
   Thyroid Gland                                      (100)        (32)         (60)         (60)         (100)                     
      C-Cell, Hyperplasia                              9 (9%)       1 (3%)       6 (10%)      9 (15%)      8 (8%)                   
      Follicle, Cyst                                                1 (3%)                                 2 (2%)                   
      Follicular Cell, Hyperplasia                                  1 (3%)                    1 (2%)       4 (4%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (98)         (32)         (58)         (59)         (98)                      
      Hyperplasia                                                                                          1 (1%)                   
      Hyperplasia, Glandular                           4 (4%)       1 (3%)       7 (12%)      6 (10%)      6 (6%)                   
      Inflammation, Chronic Active                    14 (14%)      2 (6%)      10 (17%)     11 (19%)     18 (18%)                  
      Duct, Cyst                                       8 (8%)                    3 (5%)       3 (5%)       5 (5%)                   
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05131-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 09/17/94  
Route: DOSED WATER                                                                                                Time: 03:55:26  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                    0 PPM       SPECIAL       25 PPM       100 PPM      175 PPM                     
                                                                CONTROL                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Duct, Hyperplasia, Squamous                                                                          2 (2%)                   
   Ovary                                              (100)        (32)         (60)         (60)         (100)                     
      Infiltration Cellular, Lymphocyte                                          1 (2%)                                             
      Bilateral, Periovarian Tissue, Cyst                                                                  1 (1%)                   
      Follicle, Cyst                                   1 (1%)       2 (6%)                    1 (2%)       1 (1%)                   
      Periovarian Tissue, Cyst                         2 (2%)                    6 (10%)      3 (5%)       4 (4%)                   
      Periovarian Tissue, Hemorrhage                                             1 (2%)                                             
   Uterus                                             (100)        (32)         (60)         (60)         (100)                     
      Hemorrhage                                                                                           1 (1%)                   
      Infarct, Chronic                                                                        1 (2%)                                
      Cervix, Cyst                                     2 (2%)       1 (3%)       1 (2%)       2 (3%)       4 (4%)                   
      Endometrium, Hyperplasia, Cystic, Glandular     12 (12%)      4 (13%)     13 (22%)     11 (18%)     13 (13%)                  
      Lumen, Hemorrhage                                                                       2 (3%)                                
   Vagina                                             (3)                       (2)                                                 
      Exudate                                          1 (33%)                   1 (50%)                                            
      Prolapse                                         1 (33%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (99)         (32)         (60)         (60)         (100)                     
      Femoral, Atrophy                                                                        1 (2%)                                
      Femoral, Myelofibrosis                                                     1 (2%)                    1 (1%)                   
   Lymph Node                                         (100)        (32)         (60)         (60)         (100)                     
      Mediastinal, Angiectasis                                      1 (3%)                                                          
      Mediastinal, Congestion                          1 (1%)                    1 (2%)                                             
      Renal, Angiectasis                                            1 (3%)                                                          
      Renal, Pigmentation, Hemosiderin                              1 (3%)                                                          
   Lymph Node, Mandibular                             (100)        (32)         (60)         (59)         (100)                     
      Congestion                                                                 3 (5%)                                             
      Necrosis                                                                   1 (2%)                                             
   Lymph Node, Mesenteric                             (100)        (31)         (60)         (59)         (100)                     
      Angiectasis                                                                                          1 (1%)                   
      Infiltration Cellular, Histiocyte                1 (1%)                    1 (2%)                                             
      Inflammation, Chronic Active                     1 (1%)                                                                       
   Spleen                                             (100)        (32)         (60)         (60)         (100)                     
      Depletion Lymphoid                                                         1 (2%)       1 (2%)       2 (2%)                   
      Fibrosis                                         2 (2%)       1 (3%)       1 (2%)       2 (3%)                                
      Hematopoietic Cell Proliferation                 1 (1%)                    1 (2%)                    1 (1%)                   
      Hyperplasia, Lymphoid, Nodular                   1 (1%)                                                                       
      Hyperplasia, Reticulum Cell                      2 (2%)                    1 (2%)                                             
      Infiltration Cellular, Lipocyte                  1 (1%)                                                                       
      Inflammation, Granulomatous                                                                          1 (1%)                   
      Necrosis                                         2 (2%)                                 1 (2%)                                
      Thrombosis                                                                                           1 (1%)                   
      Capsule, Fibrosis                                                          1 (2%)                    1 (1%)                   
      Red Pulp, Atrophy                                                          1 (2%)       1 (2%)                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05131-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 09/17/94  
Route: DOSED WATER                                                                                                Time: 03:55:26  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                    0 PPM       SPECIAL       25 PPM       100 PPM      175 PPM                     
                                                                CONTROL                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
   Thymus                                             (90)         (29)         (58)         (56)         (95)                      
      Depletion Lymphoid                              62 (69%)     10 (34%)     42 (72%)     43 (77%)     73 (77%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (99)         (31)         (60)         (60)         (99)                      
      Hyperplasia, Cystic                             81 (82%)     24 (77%)     51 (85%)     52 (87%)     77 (78%)                  
      Mineralization                                   1 (1%)                                                                       
   Skin                                               (99)         (32)         (60)         (59)         (100)                     
      Ulcer                                            1 (1%)                    1 (2%)                                             
      Subcutaneous Tissue, Inflammation, Chronic                                                                                    
          Active                                                                 1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (100)        (32)         (70)         (70)         (100)                     
      Cranium, Osteosclerosis                                                                 1 (1%)                                
      Femur, Fibrous Osteodystrophy                                                                        1 (1%)                   
      Femur, Osteosclerosis                                                                   1 (1%)                                
      Humerus, Fibrous Osteodystrophy                                            1 (1%)                                             
      Humerus, Osteosclerosis                          4 (4%)       4 (13%)      5 (7%)       4 (6%)      11 (11%)                  
      Joint, Cartilage, Tibia, Degeneration                                                   1 (1%)                                
      Mandible, Fibrous Osteodystrophy                 1 (1%)                                                                       
      Maxilla, Fibrous Osteodystrophy                               1 (3%)                                                          
      Maxilla, Osteosclerosis                                                                 2 (3%)       3 (3%)                   
      Thoracic, Vertebra, Fibrous Osteodystrophy       1 (1%)                                                                       
      Thoracic, Vertebra, Osteosclerosis               5 (5%)       1 (3%)       7 (10%)      5 (7%)      15 (15%)                  
      Tibia, Fibrous Osteodystrophy                    1 (1%)                                                                       
      Tibia, Osteosclerosis                            6 (6%)       2 (6%)      11 (16%)      9 (13%)     15 (15%)                  
      Vertebra, Osteosclerosis                                                   1 (1%)                                             
   Skeletal Muscle                                                              (1)                                                 
      Necrosis                                                                   1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (100)        (32)         (60)         (60)         (100)                     
      Compression                                      6 (6%)       2 (6%)       4 (7%)       7 (12%)     10 (10%)                  
      Hemorrhage                                       1 (1%)                                              1 (1%)                   
      Hydrocephalus                                    5 (5%)       1 (3%)       3 (5%)       5 (8%)       6 (6%)                   
      Necrosis                                                                                             1 (1%)                   
   Spinal Cord                                        (1)                                                                           
      Myelin, Degeneration                             1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05131-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 09/17/94  
Route: DOSED WATER                                                                                                Time: 03:55:26  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                    0 PPM       SPECIAL       25 PPM       100 PPM      175 PPM                     
                                                                CONTROL                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (100)        (32)         (60)         (60)         (100)                     
      Foreign Body                                     1 (1%)                                                                       
      Inflammation, Chronic Active                     1 (1%)                    1 (2%)       1 (2%)                                
      Mineralization                                                             1 (2%)                                             
      Alveolar Epithelium, Hyperplasia                 3 (3%)       1 (3%)       4 (7%)       2 (3%)       5 (5%)                   
      Alveolar Epithelium, Hyperplasia, Focal                                                 1 (2%)                                
   Nose                                               (100)        (32)         (60)         (60)         (100)                     
      Inflammation, Chronic Active                     1 (1%)                    1 (2%)       1 (2%)       1 (1%)                   
      Metaplasia, Squamous                             1 (1%)                    2 (3%)       1 (2%)                                
      Mucosa, Inflammation, Acute                      2 (2%)       1 (3%)                    1 (2%)       1 (1%)                   
      Mucosa, Inflammation, Chronic Active            12 (12%)      4 (13%)      7 (12%)      5 (8%)      18 (18%)                  
      Mucosa, Ulcer                                    2 (2%)                                              2 (2%)                   
      Sinus, Foreign Body                              6 (6%)       2 (6%)       5 (8%)       4 (7%)      15 (15%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                (3)                                                 (2)                       
      Pinna, Inflammation, Chronic Active                                                                  1 (50%)                  
   Eye                                                (21)         (5)          (10)         (13)         (26)                      
      Anterior Chamber, Hemorrhage                     1 (5%)                                              1 (4%)                   
      Cornea, Inflammation, Acute                                                                          1 (4%)                   
      Lens, Cataract                                  19 (90%)      5 (100%)    10 (100%)    13 (100%)    25 (96%)                  
      Retina, Atrophy                                 19 (90%)      5 (100%)    10 (100%)    13 (100%)    25 (96%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (100)        (32)         (60)         (60)         (100)                     
      Hydronephrosis                                                                                       1 (1%)                   
      Inflammation, Acute, Focal                                                 1 (2%)                                             
      Nephropathy, Chronic                            84 (84%)     27 (84%)     58 (97%)     55 (92%)     82 (82%)                  
      Cortex, Cyst                                     1 (1%)       1 (3%)                                                          
      Cortex, Infarct, Chronic, Multifocal                                                                 1 (1%)                   
      Renal Tubule, Atrophy                                                                   1 (2%)                                
      Renal Tubule, Inflammation, Chronic Active                                              1 (2%)                                
      Renal Tubule, Mineralization                     9 (9%)                                              2 (2%)                   
   Urinary Bladder                                    (100)        (32)         (59)         (60)         (100)                     
      Dilatation                                                                 1 (2%)                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 05131-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 09/17/94  
Route: DOSED WATER                                                                                                Time: 03:55:26  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                      0 PPM       SPECIAL       25 PPM       100 PPM      175 PPM                     
                                                                CONTROL                                                             
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                         100           50           70           70          100                        
  Scheduled Sacrifice                                 19                        19           20           20                        
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                21           12           13           13           19                        
    Natural Death                                     17            6           13           13           19                        
    Accidently Killed                                                                         1                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                42            5           25           23           42                        
  Special Control                                                  27                                                               
  Wrong Sex                                            1                                                                            
  Animals Examined Microscopically                    99           45           70           70          100                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (98)         (45)         (59)         (60)         (100)                     
      Congestion                                       1 (1%)                                                                       
      Ulcer                                                         1 (2%)                                                          
   Intestine Large, Colon                             (98)         (45)         (60)         (60)         (100)                     
      Ulcer                                                                      1 (2%)                                             
      Serosa, Inflammation, Chronic Active                                       1 (2%)                                             
   Intestine Large, Rectum                            (98)         (45)         (60)         (60)         (100)                     
      Parasite Metazoan                                1 (1%)                                              1 (1%)                   
      Muscularis, Inflammation, Chronic Active                                                             1 (1%)                   
   Intestine Small, Duodenum                          (99)         (45)         (60)         (60)         (100)                     
      Ulcer                                                         1 (2%)                                                          
   Intestine Small, Jejunum                           (99)         (45)         (60)         (60)         (100)                     
      Inflammation, Chronic Active, Granulomatous                                1 (2%)                                             
   Liver                                              (99)         (45)         (60)         (60)         (100)                     
      Angiectasis                                                   2 (4%)                                 2 (2%)                   
      Basophilic Focus                                18 (18%)      5 (11%)     23 (38%)     15 (25%)     24 (24%)                  
      Clear Cell Focus                                23 (23%)      2 (4%)      19 (32%)     17 (28%)     20 (20%)                  
      Congestion                                                                              2 (3%)       1 (1%)                   
      Degeneration, Cystic                                                                    1 (2%)                                
      Eosinophilic Focus                               5 (5%)       1 (2%)       3 (5%)       3 (5%)       5 (5%)                   
      Hepatodiaphragmatic Nodule                       7 (7%)       6 (13%)      5 (8%)       5 (8%)       9 (9%)                   
      Hyperplasia                                      4 (4%)       1 (2%)       3 (5%)       3 (5%)       9 (9%)                   
      Infarct                                                                                 1 (2%)                                
      Inflammation, Chronic Active                    13 (13%)      3 (7%)      11 (18%)     10 (17%)     10 (10%)                  
      Mixed Cell Focus                                                           3 (5%)                    1 (1%)                   
      Necrosis                                                                                             2 (2%)                   
      Vacuolization Cytoplasmic                       32 (32%)     28 (62%)     25 (42%)     21 (35%)     31 (31%)                  
      Bile Duct, Hyperplasia                          73 (74%)     37 (82%)     48 (80%)     48 (80%)     76 (76%)                  
      Centrilobular, Vacuolization Cytoplasmic         1 (1%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 05131-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 09/17/94  
Route: DOSED WATER                                                                                                Time: 03:55:26  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                      0 PPM       SPECIAL       25 PPM       100 PPM      175 PPM                     
                                                                CONTROL                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Hepatocyte, Cytomegaly, Focal                                              1 (2%)                                             
      Hepatocyte, Degeneration, Cystic                13 (13%)      3 (7%)       8 (13%)     10 (17%)     14 (14%)                  
      Serosa, Fibrosis                                                                        1 (2%)       1 (1%)                   
      Subserosa, Congestion                                                      1 (2%)                                             
   Mesentery                                          (13)         (6)          (9)          (5)          (18)                      
      Artery, Thrombosis                                                                      1 (20%)                               
      Fat, Hemorrhage                                               1 (17%)                                                         
      Fat, Inflammation, Chronic Active               12 (92%)      4 (67%)      7 (78%)      2 (40%)     17 (94%)                  
   Pancreas                                           (98)         (45)         (59)         (60)         (99)                      
      Acinus, Atrophy                                 34 (35%)     18 (40%)     18 (31%)     22 (37%)     20 (20%)                  
      Acinus, Hyperplasia                              1 (1%)       1 (2%)                    1 (2%)                                
      Artery, Inflammation, Chronic Active             5 (5%)       2 (4%)       5 (8%)                    6 (6%)                   
      Duct, Cyst                                                                              2 (3%)                                
      Duct, Hyperplasia                                                                                    1 (1%)                   
      Vein, Thrombosis                                 1 (1%)                                                                       
   Salivary Glands                                    (99)         (45)         (59)         (60)         (100)                     
      Acinus, Atrophy                                                                                      1 (1%)                   
   Stomach, Forestomach                               (98)         (45)         (60)         (60)         (100)                     
      Acanthosis                                       9 (9%)       2 (4%)       3 (5%)       4 (7%)       2 (2%)                   
      Inflammation, Acute                              1 (1%)                                                                       
      Inflammation, Chronic Active                     3 (3%)       1 (2%)                    1 (2%)       2 (2%)                   
      Mineralization                                   1 (1%)                                                                       
      Ulcer                                            8 (8%)       3 (7%)       8 (13%)      3 (5%)       3 (3%)                   
      Submucosa, Ectopic Tissue                                                               1 (2%)                                
   Stomach, Glandular                                 (98)         (45)         (60)         (59)         (100)                     
      Cyst Epithelial Inclusion                                                  1 (2%)                                             
      Dysplasia                                        2 (2%)                                                                       
      Erosion                                                                                 1 (2%)                                
      Hyperplasia                                      1 (1%)                                                                       
      Inflammation, Chronic Active                                                            1 (2%)                                
      Mineralization                                   3 (3%)       1 (2%)                    2 (3%)       1 (1%)                   
      Necrosis                                         4 (4%)                    3 (5%)       3 (5%)       6 (6%)                   
      Pigmentation, Hemosiderin                                                  3 (5%)       4 (7%)       2 (2%)                   
      Ulcer                                            7 (7%)       3 (7%)       3 (5%)       1 (2%)       1 (1%)                   
   Tongue                                                                       (2)                                                 
      Mucosa, Hyperplasia, Squamous                                              1 (50%)                                            
   Tooth                                              (99)         (45)         (70)         (70)         (99)                      
      Dentine, Incisor, Dysplasia                      4 (4%)                    7 (10%)     14 (20%)     31 (31%)                  
      Dentine, Incisor, Necrosis, Focal                                          1 (1%)                                             
      Dentine, Incisor, Necrosis, Multifocal          75 (76%)     33 (73%)     42 (60%)     44 (63%)     73 (74%)                  
      Incisor, Odontoblast, Degeneration                                         1 (1%)       2 (3%)       4 (4%)                   
      Incisor, Ameloblast, Degeneration                                          1 (1%)       7 (10%)     24 (24%)                  
      Peridontal Tissue, Fibrosis                                                                          1 (1%)                   
      Peridontal Tissue, Inflammation, Chronic                                                             1 (1%)                   
      Peridontal Tissue, Incisor, Inflammation,                                                                                     
           Suppurative                                                                                     2 (2%)                   
      Peridontal Tissue, Molar, Inflammation,                                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    9                                                              
NTP Experiment-Test: 05131-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 09/17/94  
Route: DOSED WATER                                                                                                Time: 03:55:26  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                      0 PPM       SPECIAL       25 PPM       100 PPM      175 PPM                     
                                                                CONTROL                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
          Chronic, Suppurative                         1 (1%)                                              1 (1%)                   
      Peridontal Tissue, Molar, Inflammation,                                                                                       
          Suppurative                                  4 (4%)                                 1 (1%)       2 (2%)                   
      Peridontal Tissue, Molar, Lower,                                                                                              
          Inflammation, Chronic, Suppurative          27 (27%)     22 (49%)     21 (30%)     19 (27%)     33 (33%)                  
      Pulp, Incisor, Inflammation, Chronic,                                                                                         
          Necrotizing                                                            1 (1%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (1)                                                                           
      Aorta, Mineralization                            1 (100%)                                                                     
   Heart                                              (99)         (45)         (60)         (60)         (100)                     
      Degeneration, Chronic                           91 (92%)     35 (78%)     55 (92%)     52 (87%)     84 (84%)                  
      Mineralization                                   2 (2%)       1 (2%)                                                          
      Thrombosis                                       6 (6%)       1 (2%)       2 (3%)       3 (5%)       4 (4%)                   
      Atrium, Dilatation                                                         1 (2%)       1 (2%)       1 (1%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland                                      (99)         (45)         (60)         (60)         (100)                     
      Capsule, Spindle Cell, Hyperplasia                                         1 (2%)                                             
   Adrenal Gland, Cortex                              (99)         (45)         (60)         (60)         (100)                     
      Accessory Adrenal Cortical Nodule                1 (1%)                                                                       
      Congestion                                                                              1 (2%)                                
      Hemorrhage                                       1 (1%)                                                                       
      Hyperplasia                                     10 (10%)      3 (7%)      12 (20%)     12 (20%)     12 (12%)                  
      Hypertrophy                                                                1 (2%)       2 (3%)       4 (4%)                   
      Vacuolization Cytoplasmic, Focal                 6 (6%)       1 (2%)       3 (5%)       6 (10%)      8 (8%)                   
      Bilateral, Degeneration, Cystic, Focal                                     1 (2%)                                             
   Adrenal Gland, Medulla                             (98)         (45)         (60)         (60)         (100)                     
      Hemorrhage                                       1 (1%)                                                                       
      Hyperplasia                                     33 (34%)     11 (24%)     21 (35%)     17 (28%)     28 (28%)                  
   Islets, Pancreatic                                 (98)         (45)         (58)         (60)         (100)                     
      Hyperplasia                                      1 (1%)                    3 (5%)       1 (2%)       2 (2%)                   
   Parathyroid Gland                                  (96)         (43)         (60)         (59)         (95)                      
      Hyperplasia                                      1 (1%)                                 2 (3%)       1 (1%)                   
   Pituitary Gland                                    (99)         (44)         (59)         (59)         (100)                     
      Pars Distalis, Congestion                        2 (2%)                    3 (5%)       5 (8%)       6 (6%)                   
      Pars Distalis, Cyst                              6 (6%)       2 (5%)       4 (7%)       4 (7%)       2 (2%)                   
      Pars Distalis, Hemorrhage                        3 (3%)                                 1 (2%)       1 (1%)                   
      Pars Distalis, Hyperplasia                      17 (17%)      6 (14%)     12 (20%)      9 (15%)      9 (9%)                   
      Pars Distalis, Inflammation, Chronic Active      1 (1%)                                                                       
      Pars Distalis, Karyomegaly                                                                           1 (1%)                   
      Pars Distalis, Vacuolization Cytoplasmic,                                                                                     
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   10                                                              
NTP Experiment-Test: 05131-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 09/17/94  
Route: DOSED WATER                                                                                                Time: 03:55:26  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                      0 PPM       SPECIAL       25 PPM       100 PPM      175 PPM                     
                                                                CONTROL                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
           Focal                                                                 1 (2%)                                             
      Pars Intermedia, Cyst                            3 (3%)       2 (5%)       1 (2%)       2 (3%)       2 (2%)                   
   Thyroid Gland                                      (99)         (45)         (60)         (60)         (100)                     
      Metaplasia, Osseous                                                                                  1 (1%)                   
      C-Cell, Hyperplasia                              5 (5%)       3 (7%)       4 (7%)       6 (10%)     10 (10%)                  
      Follicle, Cyst                                   2 (2%)                    1 (2%)       2 (3%)       2 (2%)                   
      Follicular Cell, Hyperplasia                     2 (2%)                                 1 (2%)       1 (1%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ductus Deferens                                                 (1)                                                              
      Hemorrhage                                                    1 (100%)                                                        
   Epididymis                                         (99)         (45)         (60)         (60)         (100)                     
      Dilatation                                       2 (2%)                                                                       
      Hemorrhage                                                    1 (2%)                                                          
      Inflammation, Chronic Active                                  2 (4%)                                 1 (1%)                   
   Preputial Gland                                    (99)         (45)         (60)         (57)         (100)                     
      Hyperplasia                                      1 (1%)                    1 (2%)       1 (2%)       1 (1%)                   
      Hyperplasia, Glandular                                        1 (2%)       1 (2%)                    1 (1%)                   
      Inflammation, Chronic Active                    54 (55%)     30 (67%)     46 (77%)     40 (70%)     66 (66%)                  
      Duct, Cyst                                       4 (4%)       1 (2%)       5 (8%)       4 (7%)       6 (6%)                   
   Prostate                                           (98)         (45)         (59)         (59)         (100)                     
      Atrophy                                                                                              1 (1%)                   
      Dilatation                                       4 (4%)                    1 (2%)       1 (2%)       4 (4%)                   
      Hyperplasia                                                                                          1 (1%)                   
      Inflammation, Chronic Active                    29 (30%)     11 (24%)     18 (31%)     13 (22%)     17 (17%)                  
   Seminal Vesicle                                    (97)         (45)         (60)         (59)         (97)                      
      Atrophy                                          2 (2%)                                              3 (3%)                   
      Dilatation                                                                              1 (2%)                                
      Inflammation, Chronic Active                                                            1 (2%)       1 (1%)                   
   Testes                                             (99)         (45)         (60)         (60)         (100)                     
      Interstitial Cell, Hyperplasia                  39 (39%)     30 (67%)     24 (40%)     24 (40%)     39 (39%)                  
      Seminiferous Tubule, Atrophy                    20 (20%)      5 (11%)      5 (8%)      10 (17%)     10 (10%)                  
      Serosa, Inflammation, Chronic Active                          1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   11                                                              
NTP Experiment-Test: 05131-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 09/17/94  
Route: DOSED WATER                                                                                                Time: 03:55:26  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                      0 PPM       SPECIAL       25 PPM       100 PPM      175 PPM                     
                                                                CONTROL                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (98)         (45)         (60)         (60)         (100)                     
      Femoral, Atrophy                                                           1 (2%)                                             
      Femoral, Myelofibrosis                           2 (2%)                                                                       
   Lymph Node                                         (98)         (45)         (60)         (60)         (100)                     
      Mediastinal, Congestion                                                                 1 (2%)                                
      Mediastinal, Depletion Lymphoid                               1 (2%)                                                          
      Mediastinal, Infiltration Cellular,                                                                                           
          Histiocyte                                                1 (2%)                                                          
      Mediastinal, Inflammation, Acute                                                        1 (2%)                                
      Renal, Angiectasis                                                                                   1 (1%)                   
      Renal, Congestion                                                                                    1 (1%)                   
   Lymph Node, Mandibular                             (98)         (45)         (59)         (60)         (100)                     
      Angiectasis                                      1 (1%)                    2 (3%)                    2 (2%)                   
      Congestion                                                                 1 (2%)                                             
      Infiltration Cellular, Histiocyte                             1 (2%)                                 1 (1%)                   
      Inflammation, Chronic Active                                                            1 (2%)                                
   Lymph Node, Mesenteric                             (97)         (45)         (59)         (59)         (96)                      
      Angiectasis                                                                1 (2%)       1 (2%)       1 (1%)                   
      Congestion                                                                                           1 (1%)                   
      Infiltration Cellular, Histiocyte                             1 (2%)                                                          
      Inflammation, Chronic Active                                               1 (2%)       1 (2%)                                
   Spleen                                             (98)         (45)         (60)         (60)         (100)                     
      Depletion Lymphoid                               1 (1%)       1 (2%)       1 (2%)       1 (2%)                                
      Fibrosis                                        10 (10%)      2 (4%)       7 (12%)      9 (15%)      9 (9%)                   
      Hematopoietic Cell Proliferation                                           1 (2%)       1 (2%)       1 (1%)                   
      Hyperplasia, Reticulum Cell                                   1 (2%)                                                          
      Necrosis                                                                                1 (2%)       1 (1%)                   
      Capsule, Cyst, Multiple                                       1 (2%)                                                          
      Red Pulp, Atrophy                                1 (1%)                    1 (2%)                                             
   Thymus                                             (88)         (43)         (57)         (51)         (96)                      
      Depletion Lymphoid                              54 (61%)     19 (44%)     42 (74%)     38 (75%)     66 (69%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (92)         (43)         (57)         (57)         (92)                      
      Hemorrhage                                                                                           1 (1%)                   
      Hyperplasia, Cystic                             87 (95%)     37 (86%)     55 (96%)     56 (98%)     84 (91%)                  
      Duct, Hemorrhage                                                                                     1 (1%)                   
   Skin                                               (99)         (45)         (60)         (60)         (100)                     
      Acanthosis                                       1 (1%)                                                                       
      Cyst Epithelial Inclusion                                                  2 (3%)                                             
      Hyperkeratosis                                                1 (2%)       1 (2%)       1 (2%)                                
      Ulcer                                                                      1 (2%)                                             
      Sebaceous Gland, Cyst                                                      1 (2%)                                             
      Subcutaneous Tissue, Foreign Body                             1 (2%)                                                          
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   12                                                              
NTP Experiment-Test: 05131-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 09/17/94  
Route: DOSED WATER                                                                                                Time: 03:55:26  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                      0 PPM       SPECIAL       25 PPM       100 PPM      175 PPM                     
                                                                CONTROL                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - CONT                                                                                                         
      Subcutaneous Tissue, Inflammation, Chronic                                                                                    
          Active                                                    1 (2%)       1 (2%)                    2 (2%)                   
      Subcutaneous Tissue, Metaplasia, Osseous                                                             1 (1%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (99)         (45)         (70)         (70)         (99)                      
      Epiphysis, Tibia, Cyst                                                     1 (1%)       1 (1%)                                
      Epiphysis, Tibia, Cyst, Multifocal                                         1 (1%)                                             
      Femur, Fibrous Osteodystrophy                                                                        1 (1%)                   
      Femur, Osteosclerosis                                                                                1 (1%)                   
      Humerus, Fibrous Osteodystrophy                  8 (8%)       2 (4%)       6 (9%)       8 (11%)      2 (2%)                   
      Humerus, Osteoporosis                                                      1 (1%)                                             
      Humerus, Osteosclerosis                          4 (4%)       1 (2%)       1 (1%)       1 (1%)                                
      Humerus, Joint, Cartilage, Degeneration          1 (1%)                                 1 (1%)       1 (1%)                   
      Humerus, Joint, Cartilage, Degeneration,                                                                                      
           Focal                                       1 (1%)                                              1 (1%)                   
      Humerus, Joint, Cartilage, Necrosis, Focal       1 (1%)                    1 (1%)       1 (1%)                                
      Humerus, Epiphysis, Cyst                                                   1 (1%)                                             
      Humerus, Ligament, Metaplasia, Cartilagenous,                                                                                 
           Focal                                       1 (1%)                                                                       
      Joint, Cartilage, Tibia, Degeneration                                      1 (1%)                    2 (2%)                   
      Joint, Cartilage, Tibia, Necrosis, Focal         1 (1%)                                                                       
      Mandible, Fibrous Osteodystrophy                 1 (1%)       2 (4%)       1 (1%)       3 (4%)       1 (1%)                   
      Maxilla, Fibrous Osteodystrophy                  7 (7%)       2 (4%)       5 (7%)       4 (6%)       1 (1%)                   
      Maxilla, Fibrous Osteodystrophy, Multifocal                                                          1 (1%)                   
      Thoracic, Periosteum, Vertebra, Hyperostosis     1 (1%)                                                                       
      Thoracic, Vertebra, Fibrous Osteodystrophy       7 (7%)       1 (2%)       3 (4%)       6 (9%)       3 (3%)                   
      Thoracic, Vertebra, Osteosclerosis                                                      1 (1%)                                
      Thoracic, Vertebra, Intervertebral Disc,                                                                                      
           Degeneration                                1 (1%)                                                                       
      Tibia, Fibrous Osteodystrophy                   10 (10%)      3 (7%)       5 (7%)       5 (7%)       2 (2%)                   
      Tibia, Necrosis, Focal                                                                               1 (1%)                   
      Tibia, Osteoporosis                                                        1 (1%)                                             
      Tibia, Osteosclerosis                            2 (2%)       1 (2%)       1 (1%)       4 (6%)       3 (3%)                   
      Tibia, Thrombosis, Chronic, Focal                                          1 (1%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (99)         (45)         (60)         (60)         (100)                     
      Compression                                      2 (2%)       1 (2%)       3 (5%)       3 (5%)       2 (2%)                   
      Degeneration                                     1 (1%)                                                                       
      Hemorrhage                                                                                           1 (1%)                   
      Hydrocephalus                                    2 (2%)                    2 (3%)       2 (3%)       1 (1%)                   
      Necrosis, Subacute                               1 (1%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   13                                                              
NTP Experiment-Test: 05131-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 09/17/94  
Route: DOSED WATER                                                                                                Time: 03:55:26  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                      0 PPM       SPECIAL       25 PPM       100 PPM      175 PPM                     
                                                                CONTROL                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
NERVOUS SYSTEM - CONT                                                                                                               
      Vein, Thrombosis                                                                                     1 (1%)                   
   Peripheral Nerve                                   (1)          (1)                                    (1)                       
      Sciatic, Degeneration                                         1 (100%)                               1 (100%)                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (99)         (45)         (60)         (60)         (100)                     
      Hemorrhage                                                    1 (2%)                                                          
      Inflammation, Chronic Active                     1 (1%)       2 (4%)                                 2 (2%)                   
      Inflammation, Chronic Active, Focal                                                     1 (2%)                                
      Mineralization                                   1 (1%)                                                                       
      Alveolar Epithelium, Hyperplasia                 3 (3%)       2 (4%)       2 (3%)       5 (8%)       3 (3%)                   
      Pleura, Hyperplasia                                                                                  1 (1%)                   
      Pleura, Inflammation, Chronic Active                                       1 (2%)       1 (2%)                                
   Nose                                               (99)         (45)         (60)         (60)         (100)                     
      Inflammation, Chronic Active                     4 (4%)                    1 (2%)       3 (5%)       3 (3%)                   
      Metaplasia, Squamous                             4 (4%)       1 (2%)                    1 (2%)       3 (3%)                   
      Mucosa, Inflammation, Acute                                   7 (16%)      1 (2%)       2 (3%)       5 (5%)                   
      Mucosa, Inflammation, Chronic Active            25 (25%)      6 (13%)     17 (28%)     14 (23%)     22 (22%)                  
      Mucosa, Ulcer                                    1 (1%)       3 (7%)                    2 (3%)       1 (1%)                   
      Sinus, Foreign Body                             20 (20%)      4 (9%)      15 (25%)     11 (18%)     22 (22%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                (3)          (1)          (1)          (1)                                    
      Pinna, Acanthosis                                1 (33%)                                                                      
   Eye                                                (23)         (3)          (7)          (14)         (16)                      
      Cornea, Hyperplasia, Squamous                                              1 (14%)                                            
      Cornea, Inflammation, Chronic Active                                       1 (14%)                                            
      Lens, Cataract                                  21 (91%)      3 (100%)     7 (100%)    14 (100%)    16 (100%)                 
      Retina, Atrophy                                 22 (96%)      3 (100%)     5 (71%)     14 (100%)    16 (100%)                 
   Harderian Gland                                    (1)          (2)                                    (1)                       
      Hyperplasia                                                   1 (50%)                                                         
   Zymbal's Gland                                     (3)          (1)          (2)          (1)          (3)                       
      Cyst, Multiple                                                             1 (50%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (98)         (45)         (60)         (60)         (100)                     
      Hydronephrosis                                                                          1 (2%)                                
      Nephropathy, Chronic                            97 (99%)     44 (98%)     60 (100%)    60 (100%)    99 (99%)                  
      Cortex, Cyst                                     3 (3%)                    2 (3%)       4 (7%)       2 (2%)                   
      Renal Tubule, Necrosis, Acute, Multifocal                                                            1 (1%)                   
      Renal Tubule, Epithelium, Hyperplasia, Focal                                                         1 (1%)                   
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   14                                                              
NTP Experiment-Test: 05131-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 09/17/94  
Route: DOSED WATER                                                                                                Time: 03:55:26  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                      0 PPM       SPECIAL       25 PPM       100 PPM      175 PPM                     
                                                                CONTROL                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
URINARY SYSTEM - CONT                                                                                                               
   Urinary Bladder                                    (98)         (44)         (60)         (58)         (100)                     
      Calculus Micro Observation Only                  1 (1%)                                                                       
      Ectasia                                                                                 1 (2%)                                
      Mucosa, Hyperplasia                                                                                  1 (1%)                   
      Submucosa, Hemorrhage                                                                   1 (2%)                                
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   15                                                              
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                             ----------              END OF REPORT             ----------                                           
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NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.