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TR 393 Rat Pathology Tables


                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                          SODIUM FLUORIDE


NTP Experiment-Test: 05131-01                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 09/17/94
Route: DOSED WATER                                                                                                Time: 03:55:29




       Facility:  Battelle Columbus Laboratory

       Chemical CAS #:  7681-49-4

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05131-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 09/17/94  
Route: DOSED WATER                                                                                                Time: 03:55:29  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                    0 PPM       SPECIAL       25 PPM       100 PPM      175 PPM                     
                                                                CONTROL                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                         100           50           70           70          100                        
  Scheduled Sacrifice                                 20                        20           20           19                        
  Early Deaths                                                                                                                      
    Natural Death                                     10            4           11            6           10                        
    Moribund Sacrifice                                11            7            8           10           17                        
  Survivors                                                                                                                         
    Terminal Sacrifice                                59           18           31           34           54                        
  Special Control                                                  21                                                               
  Animals Examined Microscopically                   100           32           70           70          100                        
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Rectum                            (100)        (32)         (59)         (60)         (100)                     
      Adenocarcinoma                                                1 (3%)                                                          
      Leiomyosarcoma, Metastatic, Vagina                                         1 (2%)                                             
   Intestine Small, Jejunum                           (100)        (32)         (60)         (60)         (100)                     
      Leiomyoma                                        1 (1%)                                              1 (1%)                   
   Liver                                              (100)        (32)         (60)         (60)         (100)                     
      Hepatocellular Adenoma                           2 (2%)                                 1 (2%)       1 (1%)                   
   Mesentery                                          (4)          (1)          (3)          (2)          (2)                       
      Histiocytic Sarcoma, Metastatic, Skin                                                   1 (50%)                               
   Oral Mucosa                                        (1)                                                 (2)                       
      Gingival, Squamous Cell Carcinoma                1 (100%)                                            2 (100%)                 
   Pancreas                                           (100)        (32)         (60)         (60)         (99)                      
      Histiocytic Sarcoma, Metastatic, Skin                                                   1 (2%)                                
      Acinus, Adenoma                                  1 (1%)                                                                       
   Pharynx                                                                      (1)          (2)          (1)                       
      Palate, Squamous Cell Carcinoma                                                                      1 (100%)                 
      Palate, Squamous Cell Papilloma                                            1 (100%)     1 (50%)                               
   Salivary Glands                                    (100)        (32)         (60)         (59)         (97)                      
      Histiocytic Sarcoma, Metastatic, Skin                                                   1 (2%)                                
   Stomach, Glandular                                 (100)        (32)         (60)         (60)         (100)                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (100)        (32)         (60)         (60)         (100)                     
      Granulosa Cell Tumor Malignant, Metastatic,                                                                                   
           Ovary                                       1 (1%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   2                                                               
NTP Experiment-Test: 05131-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 09/17/94  
Route: DOSED WATER                                                                                                Time: 03:55:29  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                    0 PPM       SPECIAL       25 PPM       100 PPM      175 PPM                     
                                                                CONTROL                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (100)        (32)         (60)         (60)         (100)                     
      Adenoma                                          1 (1%)                                              1 (1%)                   
   Adrenal Gland, Medulla                             (100)        (32)         (59)         (60)         (100)                     
      Granulosa Cell Tumor Malignant, Metastatic,                                                                                   
           Ovary                                       1 (1%)                                                                       
      Pheochromocytoma Malignant                                                              1 (2%)       1 (1%)                   
      Pheochromocytoma Benign                          5 (5%)                    2 (3%)       1 (2%)       5 (5%)                   
      Bilateral, Pheochromocytoma Benign               1 (1%)                                                                       
   Islets, Pancreatic                                 (100)        (32)         (60)         (60)         (99)                      
      Adenoma                                          3 (3%)                    1 (2%)       1 (2%)                                
      Carcinoma                                                                               1 (2%)                                
   Parathyroid Gland                                  (99)         (32)         (56)         (55)         (97)                      
      Adenoma                                                                                 1 (2%)       1 (1%)                   
   Pituitary Gland                                    (99)         (32)         (60)         (60)         (100)                     
      Pars Distalis, Adenoma                          32 (32%)      7 (22%)     23 (38%)     21 (35%)     28 (28%)                  
      Pars Distalis, Adenoma, Multiple                                           1 (2%)       1 (2%)       4 (4%)                   
      Pars Distalis, Carcinoma                                                                2 (3%)                                
      Pars Intermedia, Adenoma                                                   1 (2%)                                             
      Pars Intermedia, Carcinoma                       1 (1%)                                                                       
   Thyroid Gland                                      (100)        (32)         (60)         (60)         (100)                     
      Bilateral, C-Cell, Adenoma                                                                           1 (1%)                   
      Bilateral, Follicular Cell, Carcinoma                                                   1 (2%)                                
      C-Cell, Adenoma                                 13 (13%)      7 (22%)      4 (7%)       7 (12%)     12 (12%)                  
      C-Cell, Carcinoma                                1 (1%)                                 1 (2%)       1 (1%)                   
      Follicular Cell, Adenoma                                                                1 (2%)       1 (1%)                   
      Follicular Cell, Carcinoma                       2 (2%)                                 1 (2%)       1 (1%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (98)         (32)         (58)         (59)         (98)                      
      Adenoma                                          9 (9%)                    1 (2%)       5 (8%)      11 (11%)                  
      Carcinoma                                        1 (1%)                    1 (2%)                    1 (1%)                   
      Bilateral, Adenoma                               1 (1%)                                 1 (2%)       1 (1%)                   
      Bilateral, Carcinoma                                                       1 (2%)                                             
   Ovary                                              (100)        (32)         (60)         (60)         (100)                     
      Granulosa Cell Tumor Malignant                   1 (1%)                                                                       
      Periovarian Tissue, Lymphangioma                              1 (3%)                                                          
   Uterus                                             (100)        (32)         (60)         (60)         (100)                     
      Adenoma                                                                    1 (2%)                    2 (2%)                   
      Hemangioma                                                                                           1 (1%)                   
                                                             Page   3                                                               
NTP Experiment-Test: 05131-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 09/17/94  
Route: DOSED WATER                                                                                                Time: 03:55:29  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                    0 PPM       SPECIAL       25 PPM       100 PPM      175 PPM                     
                                                                CONTROL                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - cont                                                                                                               
      Leiomyosarcoma                                                1 (3%)                                                          
      Lymphangiosarcoma                                                                                    1 (1%)                   
      Polyp Stromal                                   12 (12%)      1 (3%)       4 (7%)       7 (12%)      2 (2%)                   
      Cervix, Carcinoma                                                                                    1 (1%)                   
      Cervix, Fibroma                                                                                      1 (1%)                   
      Cervix, Fibrosarcoma                             1 (1%)                                                                       
      Cervix, Sarcoma Stromal                                                                              1 (1%)                   
   Vagina                                             (3)                       (2)                                                 
      Fibrosarcoma                                     1 (33%)                                                                      
      Leiomyosarcoma                                   1 (33%)                   1 (50%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (99)         (32)         (60)         (60)         (100)                     
   Lymph Node                                         (100)        (32)         (60)         (60)         (100)                     
      Deep Cervical, Carcinoma, Metastatic,                                                                                         
          Thyroid Gland                                                                                    1 (1%)                   
   Lymph Node, Mandibular                             (100)        (32)         (60)         (59)         (100)                     
      Fibrosarcoma, Metastatic, Skin                                                          1 (2%)                                
      Histiocytic Sarcoma, Metastatic, Skin                                                   1 (2%)                                
   Lymph Node, Mesenteric                             (100)        (31)         (60)         (59)         (100)                     
   Spleen                                             (100)        (32)         (60)         (60)         (100)                     
   Thymus                                             (90)         (29)         (58)         (56)         (95)                      
      Thymoma Benign                                   1 (1%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (99)         (31)         (60)         (60)         (99)                      
      Adenocarcinoma                                                                                       1 (1%)                   
      Adenocarcinoma, Multiple                                                   1 (2%)                                             
      Adenoma                                                                    1 (2%)       1 (2%)       1 (1%)                   
      Fibroadenoma                                    20 (20%)      6 (19%)     12 (20%)     12 (20%)     19 (19%)                  
      Fibroadenoma, Multiple                           2 (2%)       2 (6%)       1 (2%)       3 (5%)       5 (5%)                   
   Skin                                               (99)         (32)         (60)         (59)         (100)                     
      Keratoacanthoma                                                                                      2 (2%)                   
      Keratoacanthoma, Multiple                                                                            1 (1%)                   
      Squamous Cell Papilloma                                       1 (3%)                                                          
      Trichoepithelioma                                1 (1%)                                                                       
      Subcutaneous Tissue, Fibroma                                               1 (2%)                    1 (1%)                   
      Subcutaneous Tissue, Fibrosarcoma                                                       1 (2%)       1 (1%)                   
      Subcutaneous Tissue, Fibrous Histiocytoma                                                            1 (1%)                   
      Subcutaneous Tissue, Granulosa Cell Tumor                                                                                     
          Malignant, Metastatic, Ovary                 1 (1%)                                                                       
      Subcutaneous Tissue, Histiocytic Sarcoma                                                1 (2%)                                
      Subcutaneous Tissue, Lipoma                                                                          1 (1%)                   
                                                             Page   4                                                               
NTP Experiment-Test: 05131-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 09/17/94  
Route: DOSED WATER                                                                                                Time: 03:55:29  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                    0 PPM       SPECIAL       25 PPM       100 PPM      175 PPM                     
                                                                CONTROL                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
INTEGUMENTARY SYSTEM - cont                                                                                                         
      Subcutaneous Tissue, Schwannoma Malignant,                                                                                    
           Metastatic, Eye                                          1 (3%)                                                          
      Sweat Gland, Adenoma                                                                                 1 (1%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                                              (1)                                                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (100)        (32)         (60)         (60)         (100)                     
      Astrocytoma Malignant                            1 (1%)                                 1 (2%)       1 (1%)                   
      Carcinoma, Metastatic, Pituitary Gland                                                  2 (3%)                                
      Carcinoma, Metastatic, Zymbal's Gland                                                                1 (1%)                   
      Glioma Malignant                                                                        1 (2%)                                
      Histiocytic Sarcoma, Metastatic, Skin                                                   1 (2%)                                
      Oligodendroglioma Malignant                                                                          1 (1%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (100)        (32)         (60)         (60)         (100)                     
      Alveolar/Bronchiolar Adenoma                     2 (2%)                    1 (2%)                    1 (1%)                   
      Alveolar/Bronchiolar Carcinoma                                                          1 (2%)                                
      Carcinoma, Metastatic, Thyroid Gland                                                    1 (2%)                                
      Fibrosarcoma, Metastatic, Skin                                                          1 (2%)                                
      Granulosa Cell Tumor Malignant, Metastatic,                                                                                   
           Ovary                                       1 (1%)                                                                       
      Histiocytic Sarcoma, Metastatic, Skin                                                   1 (2%)                                
   Nose                                               (100)        (32)         (60)         (60)         (100)                     
      Histiocytic Sarcoma, Metastatic, Skin                                                   1 (2%)                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                (3)                                                 (2)                       
      Pinna, Fibroma                                   1 (33%)                                                                      
      Pinna, Fibrosarcoma                              2 (67%)                                             1 (50%)                  
   Eye                                                (21)         (5)          (10)         (13)         (26)                      
      Optic Nerve, Schwannoma Malignant                             1 (20%)                                                         
   Harderian Gland                                                                           (1)          (1)                       
      Fibrosarcoma, Metastatic, Skin                                                          1 (100%)                              
   Zymbal's Gland                                     (1)                                    (1)          (1)                       
      Carcinoma                                        1 (100%)                               1 (100%)     1 (100%)                 
____________________________________________________________________________________________________________________________________
                                                             Page   5                                                               
NTP Experiment-Test: 05131-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 09/17/94  
Route: DOSED WATER                                                                                                Time: 03:55:29  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                    0 PPM       SPECIAL       25 PPM       100 PPM      175 PPM                     
                                                                CONTROL                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (100)        (32)         (60)         (60)         (100)                     
      Granulosa Cell Tumor Malignant, Metastatic,                                                                                   
           Ovary                                       1 (1%)                                                                       
      Mast Cell Tumor Malignant                                                  1 (2%)                                             
   Urinary Bladder                                    (100)        (32)         (59)         (60)         (100)                     
      Leiomyosarcoma, Metastatic, Vagina                                         1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(100)       *(32)        *(70)        *(70)        *(100)                     
      Histiocytic Sarcoma                                                                     1 (1%)                                
      Leukemia Mononuclear                            26 (26%)      7 (22%)     16 (23%)     14 (20%)     20 (20%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   6                                                               
NTP Experiment-Test: 05131-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 09/17/94  
Route: DOSED WATER                                                                                                Time: 03:55:29  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                    0 PPM       SPECIAL       25 PPM       100 PPM      175 PPM                     
                                                                CONTROL                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            73          22          45          51          74                           
     Total Primary Neoplasms                          148          35          76          91         142                           
                                                                                                                                    
   Total Animals with Benign Neoplasms                 63          17          39          40          61                           
     Total Benign Neoplasms                           108          25          55          64         105                           
                                                                                                                                    
   Total Animals with Malignant Neoplasms              38           8          21          25          32                           
     Total Malignant Neoplasms                         40          10          21          27          37                           
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              1           1           1           5           2                           
     Total Metastatic Neoplasm                          5           1           2          13           2                           
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   7                                                               
NTP Experiment-Test: 05131-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 09/17/94  
Route: DOSED WATER                                                                                                Time: 03:55:29  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                      0 PPM       SPECIAL       25 PPM       100 PPM      175 PPM                     
                                                                CONTROL                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                         100           50           70           70          100                        
  Scheduled Sacrifice                                 19                        19           20           20                        
  Early Deaths                                                                                                                      
    Moribund Sacrifice                                21           12           13           13           19                        
    Natural Death                                     17            6           13           13           19                        
    Accidently Killed                                                                         1                                     
  Survivors                                                                                                                         
    Terminal Sacrifice                                42            5           25           23           42                        
  Special Control                                                  27                                                               
  Wrong Sex                                            1                                                                            
  Animals Examined Microscopically                    99           45           70           70          100                        
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (98)         (45)         (60)         (60)         (100)                     
      Adenocarcinoma                                   1 (1%)                                                                       
   Intestine Small, Ileum                             (98)         (45)         (60)         (60)         (99)                      
      Adenocarcinoma                                                1 (2%)                                                          
   Intestine Small, Jejunum                           (99)         (45)         (60)         (60)         (100)                     
      Adenocarcinoma                                                                                       1 (1%)                   
      Leiomyoma                                                                                            1 (1%)                   
   Liver                                              (99)         (45)         (60)         (60)         (100)                     
      Fibrosarcoma, Metastatic, Skin                                                          1 (2%)                                
      Hepatocellular Adenoma                           1 (1%)                    1 (2%)       1 (2%)       1 (1%)                   
      Histiocytic Sarcoma, Multiple                                                                        1 (1%)                   
   Mesentery                                          (13)         (6)          (9)          (5)          (18)                      
      Histiocytic Sarcoma                                                                     1 (20%)                               
      Liposarcoma                                                                1 (11%)                                            
   Oral Mucosa                                                     (1)                       (1)          (2)                       
      Buccal, Squamous Cell Carcinoma                               1 (100%)                                                        
      Buccal, Squamous Cell Papilloma                                                                      1 (50%)                  
      Gingival, Squamous Cell Carcinoma                                                       1 (100%)     1 (50%)                  
   Pancreas                                           (98)         (45)         (59)         (60)         (99)                      
      Histiocytic Sarcoma, Metastatic, Mesentery                                              1 (2%)                                
      Acinus, Adenoma                                                            1 (2%)                                             
   Pharynx                                                                                   (1)          (1)                       
      Palate, Squamous Cell Papilloma                                                         1 (100%)     1 (100%)                 
   Salivary Glands                                    (99)         (45)         (59)         (60)         (100)                     
      Carcinoma                                                     1 (2%)                                                          
      Hemangiosarcoma, Metastatic, Skin                             1 (2%)                                                          
   Stomach, Forestomach                               (98)         (45)         (60)         (60)         (100)                     
      Basal Cell Adenoma                               1 (1%)                                                                       
                                                             Page   8                                                               
NTP Experiment-Test: 05131-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 09/17/94  
Route: DOSED WATER                                                                                                Time: 03:55:29  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                      0 PPM       SPECIAL       25 PPM       100 PPM      175 PPM                     
                                                                CONTROL                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - cont                                                                                                            
      Squamous Cell Papilloma                                                                 1 (2%)                                
   Stomach, Glandular                                 (98)         (45)         (60)         (59)         (100)                     
   Tongue                                                                       (2)                                                 
      Squamous Cell Papilloma                                                    1 (50%)                                            
   Tooth                                              (99)         (45)         (70)         (70)         (99)                      
      Gingiva, Molar, Lower, Squamous Cell                                                                                          
          Carcinoma, Metastatic                        1 (1%)                                                                       
      Peridontal Tissue, Squamous Cell Carcinoma,                                                                                   
           Metastatic                                                                                      1 (1%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (99)         (45)         (60)         (60)         (100)                     
      Hemangiosarcoma                                                                                      1 (1%)                   
      Endocardium, Ventricle Left, Schwannoma                                                                                       
          Benign                                       1 (1%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (99)         (45)         (60)         (60)         (100)                     
      Adenoma                                          1 (1%)                                 1 (2%)       1 (1%)                   
   Adrenal Gland, Medulla                             (98)         (45)         (60)         (60)         (100)                     
      Pheochromocytoma Malignant                       2 (2%)                                 1 (2%)                                
      Pheochromocytoma Complex                         1 (1%)                                                                       
      Pheochromocytoma Benign                         19 (19%)      6 (13%)     13 (22%)      8 (13%)     22 (22%)                  
      Bilateral, Pheochromocytoma Benign               5 (5%)       2 (4%)       8 (13%)      7 (12%)      8 (8%)                   
   Islets, Pancreatic                                 (98)         (45)         (58)         (60)         (100)                     
      Adenoma                                          2 (2%)       1 (2%)                    3 (5%)       4 (4%)                   
      Carcinoma                                        1 (1%)                    1 (2%)       1 (2%)       1 (1%)                   
   Parathyroid Gland                                  (96)         (43)         (60)         (59)         (95)                      
      Adenoma                                          4 (4%)                    1 (2%)       1 (2%)       1 (1%)                   
      Carcinoma, Metastatic, Thyroid Gland                                                                 1 (1%)                   
   Pituitary Gland                                    (99)         (44)         (59)         (59)         (100)                     
      Pars Distalis, Adenoma                          16 (16%)      3 (7%)       9 (15%)      9 (15%)     15 (15%)                  
      Pars Distalis, Carcinoma                                                                1 (2%)                                
      Pars Intermedia, Carcinoma                                                 1 (2%)                                             
   Thyroid Gland                                      (99)         (45)         (60)         (60)         (100)                     
      Bilateral, C-Cell, Adenoma                                    1 (2%)       1 (2%)       1 (2%)       2 (2%)                   
      Bilateral, C-Cell, Carcinoma                                               1 (2%)                                             
      C-Cell, Adenoma                                 14 (14%)      6 (13%)      9 (15%)      9 (15%)     11 (11%)                  
      C-Cell, Carcinoma                                1 (1%)                                              4 (4%)                   
      Follicular Cell, Adenoma                                                                1 (2%)       3 (3%)                   
      Follicular Cell, Carcinoma                       1 (1%)                    1 (2%)                    2 (2%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   9                                                               
NTP Experiment-Test: 05131-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 09/17/94  
Route: DOSED WATER                                                                                                Time: 03:55:29  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                      0 PPM       SPECIAL       25 PPM       100 PPM      175 PPM                     
                                                                CONTROL                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                         (1)                       (2)          (1)          (2)                       
      Chordoma                                                                   1 (50%)                                            
      Fibrosarcoma                                                                            1 (100%)                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (99)         (45)         (60)         (60)         (100)                     
   Preputial Gland                                    (99)         (45)         (60)         (57)         (100)                     
      Adenoma                                          7 (7%)       2 (4%)       5 (8%)       3 (5%)       5 (5%)                   
      Carcinoma                                        1 (1%)       1 (2%)       3 (5%)       1 (2%)       4 (4%)                   
   Prostate                                           (98)         (45)         (59)         (59)         (100)                     
   Seminal Vesicle                                    (97)         (45)         (60)         (59)         (97)                      
   Testes                                             (99)         (45)         (60)         (60)         (100)                     
      Bilateral, Interstitial Cell, Adenoma           58 (59%)     21 (47%)     39 (65%)     38 (63%)     63 (63%)                  
      Interstitial Cell, Adenoma                      14 (14%)     14 (31%)     13 (22%)     14 (23%)     14 (14%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (98)         (45)         (60)         (60)         (100)                     
      Carcinoma, Metastatic, Thyroid Gland                                       1 (2%)                                             
   Lymph Node                                         (98)         (45)         (60)         (60)         (100)                     
      Axillary, Carcinoma, Metastatic, Thyroid                                                                                      
          Gland                                                                  1 (2%)                                             
      Deep Cervical, Carcinoma, Metastatic,                                                                                         
          Thyroid Gland                                                                                    1 (1%)                   
      Mediastinal, Carcinoma, Metastatic, Thyroid                                                                                   
          Gland                                                                  1 (2%)                                             
      Mediastinal, Histiocytic Sarcoma, Metastatic,                                                                                 
           Spleen                                                                1 (2%)                                             
   Lymph Node, Mandibular                             (98)         (45)         (59)         (60)         (100)                     
      Carcinoma, Metastatic, Thyroid Gland                                       1 (2%)                                             
      Hemangiosarcoma, Metastatic, Skin                             1 (2%)                                                          
      Histiocytic Sarcoma, Metastatic, Spleen                                    1 (2%)                                             
   Lymph Node, Mesenteric                             (97)         (45)         (59)         (59)         (96)                      
      Histiocytic Sarcoma, Metastatic, Spleen                                    1 (2%)                                             
   Spleen                                             (98)         (45)         (60)         (60)         (100)                     
      Fibrosarcoma                                     1 (1%)                                 1 (2%)                                
      Fibrous Histiocytoma                                          1 (2%)                                                          
      Hemangioma                                                                                           1 (1%)                   
      Histiocytic Sarcoma                                                        3 (5%)                                             
   Thymus                                             (88)         (43)         (57)         (51)         (96)                      
      Thymoma Malignant                                             1 (2%)                                 1 (1%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page  10                                                               
NTP Experiment-Test: 05131-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 09/17/94  
Route: DOSED WATER                                                                                                Time: 03:55:29  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                      0 PPM       SPECIAL       25 PPM       100 PPM      175 PPM                     
                                                                CONTROL                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (92)         (43)         (57)         (57)         (92)                      
      Fibroadenoma                                     6 (7%)                    1 (2%)                    2 (2%)                   
   Skin                                               (99)         (45)         (60)         (60)         (100)                     
      Basal Cell Adenoma                               1 (1%)                                                                       
      Basal Cell Carcinoma                                                                    1 (2%)                                
      Keratoacanthoma                                  8 (8%)       1 (2%)       2 (3%)       2 (3%)       8 (8%)                   
      Keratoacanthoma, Multiple                        1 (1%)       1 (2%)                                                          
      Papilloma                                                                  1 (2%)                    2 (2%)                   
      Squamous Cell Papilloma                          1 (1%)                    2 (3%)       1 (2%)       2 (2%)                   
      Trichoepithelioma                                                                       1 (2%)                                
      Sebaceous Gland, Adenoma                                      1 (2%)                                                          
      Subcutaneous Tissue, Fibroma                                               2 (3%)       3 (5%)       4 (4%)                   
      Subcutaneous Tissue, Fibrosarcoma                1 (1%)                                 1 (2%)                                
      Subcutaneous Tissue, Hemangiosarcoma                          1 (2%)                                                          
      Subcutaneous Tissue, Lipoma                      1 (1%)                                                                       
      Subcutaneous Tissue, Neurofibroma                                          1 (2%)       1 (2%)                                
      Subcutaneous Tissue, Neurofibrosarcoma                                     1 (2%)                                             
      Subcutaneous Tissue, Neurofibrosarcoma,                                                                                       
          Multiple                                                               1 (2%)                                             
      Subcutaneous Tissue, Osteosarcoma                                                                    1 (1%)                   
      Subcutaneous Tissue, Osteosarcoma,                                                                                            
          Metastatic, Bone                                                                                 1 (1%)                   
      Subcutaneous Tissue, Schwannoma Malignant                     1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (99)         (45)         (70)         (70)         (99)                      
      Humerus, Osteosarcoma                                                                                1 (1%)                   
      Vertebra, Osteosarcoma                                                                               2 (2%)                   
      Vertebra, Coccygeal, Osteosarcoma                                                       1 (1%)                                
   Skeletal Muscle                                    (1)          (1)                       (1)          (1)                       
      Diaphragm, Histiocytic Sarcoma, Metastatic,                                                                                   
           Mesentery                                                                          1 (100%)                              
      Diaphragm, Thymoma Malignant, Metastatic,                                                                                     
           Thymus                                                                                          1 (100%)                 
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (99)         (45)         (60)         (60)         (100)                     
      Granular Cell Tumor Malignant                                              1 (2%)                                             
      Meninges, Carcinoma, Metastatic, Zymbal's                                                                                     
          Gland                                                                                            1 (1%)                   
   Spinal Cord                                        (1)          (2)                                    (2)                       
      Astrocytoma Malignant                            1 (100%)                                                                     
                                                             Page  11                                                               
NTP Experiment-Test: 05131-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 09/17/94  
Route: DOSED WATER                                                                                                Time: 03:55:29  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                      0 PPM       SPECIAL       25 PPM       100 PPM      175 PPM                     
                                                                CONTROL                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
NERVOUS SYSTEM - cont                                                                                                               
      Osteosarcoma, Metastatic, Bone                                                                       1 (50%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (99)         (45)         (60)         (60)         (100)                     
      Alveolar/Bronchiolar Adenoma                                               1 (2%)       1 (2%)       1 (1%)                   
      Carcinoma, Metastatic, Prostate                                                         1 (2%)                                
      Carcinoma, Metastatic, Thyroid Gland             1 (1%)                    1 (2%)                                             
      Carcinoma, Metastatic, Zymbal's Gland                                                                1 (1%)                   
      Fibrosarcoma, Metastatic, Ear                                                           1 (2%)                                
      Osteosarcoma, Multiple, Metastatic, Bone                                                1 (2%)                                
      Thymoma Malignant, Metastatic, Thymus                         1 (2%)                                                          
      Mediastinum, Histiocytic Sarcoma, Metastatic,                                                                                 
           Mesentery                                                                          1 (2%)                                
      Mediastinum, Thymoma Malignant, Metastatic,                                                                                   
           Thymus                                                                                          1 (1%)                   
   Nose                                               (99)         (45)         (60)         (60)         (100)                     
      Mucosa, Squamous Cell Carcinoma                                                                      1 (1%)                   
      Mucosa, Squamous Cell Papilloma                                                                      1 (1%)                   
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                (3)          (1)          (1)          (1)                                    
      Pinna, Fibroma                                                             1 (100%)                                           
      Pinna, Fibrosarcoma                                                                     1 (100%)                              
      Pinna, Neurofibrosarcoma                         1 (33%)      1 (100%)                                                        
      Pinna, Squamous Cell Carcinoma                   1 (33%)                                                                      
   Zymbal's Gland                                     (3)          (1)          (2)          (1)          (3)                       
      Carcinoma                                        3 (100%)     1 (100%)     1 (50%)      1 (100%)     2 (67%)                  
      Bilateral, Carcinoma                                                                                 1 (33%)                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (98)         (45)         (60)         (60)         (100)                     
      Liposarcoma                                                                                          1 (1%)                   
      Cortex, Myxoma                                                                          1 (2%)                                
      Renal Tubule, Adenoma                                                      1 (2%)                    1 (1%)                   
   Urinary Bladder                                    (98)         (44)         (60)         (58)         (100)                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(99)        *(45)        *(70)        *(70)        *(100)                     
      Histiocytic Sarcoma                                                        3 (4%)       1 (1%)       1 (1%)                   
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  12                                                               
NTP Experiment-Test: 05131-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 09/17/94  
Route: DOSED WATER                                                                                                Time: 03:55:29  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                      0 PPM       SPECIAL       25 PPM       100 PPM      175 PPM                     
                                                                CONTROL                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 SYSTEMIC LESIONS - cont                                                                                                            
   Multiple Organs                                   *(99)        *(45)        *(70)        *(70)        *(100)                     
      Leukemia Monocytic                               1 (1%)                                                                       
      Leukemia Mononuclear                            57 (58%)     14 (31%)     23 (33%)     21 (30%)     47 (47%)                  
      Mesothelioma Benign                              1 (1%)                                              2 (2%)                   
      Mesothelioma Malignant                                        3 (7%)       1 (1%)       1 (1%)                                
____________________________________________________________________________________________________________________________________
                                                             Page  13                                                               
NTP Experiment-Test: 05131-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                          SODIUM FLUORIDE                                      Date: 09/17/94  
Route: DOSED WATER                                                                                                Time: 03:55:29  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                      0 PPM       SPECIAL       25 PPM       100 PPM      175 PPM                     
                                                                CONTROL                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            80          38          58          56          88                           
     Total Primary Neoplasms                          236          86         153         143         249                           
                                                                                                                                    
   Total Animals with Benign Neoplasms                 77          35          56          54          83                           
     Total Benign Neoplasms                           162          59         113         108         177                           
                                                                                                                                    
   Total Animals with Malignant Neoplasms              61          22          31          29          63                           
     Total Malignant Neoplasms                         74          27          40          35          72                           
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              2           3           2           5           7                           
     Total Metastatic Neoplasm                          2           7           8           7           9                           
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  14                                                               
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