TR 395 Mouse Pathology Tables
INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
PROBENECID
NTP Experiment-Test: 05030-02 Report: PEIRPT03
Study Type: CHRONIC Date: 09/04/94
Route: GAVAGE Time: 15:09:51
Facility: TSI Mason Research
Chemical CAS #: 000057669
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05030-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC PROBENECID Date: 09/04/94
Route: GAVAGE Time: 15:09:51
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE .1G/KG .4G/KG
FEMALE LF HF
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50
Early Deaths
Moribund 9 9 9
Dead 8 7 9
Accident 1
Survivors
Terminal Sacrifice 32 31 32
Moribund 1
Other 1 1
Animals Examined Microscopically 49 49 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Intestine Large, Colon (48) (15) (49)
Lymphoid Nodule, Hyperplasia 1 (7%)
Intestine Small, Ileum (47) (16) (46)
Necrosis 1 (2%)
Lymphoid Nodule, Hyperplasia 1 (2%)
Intestine Small, Jejunum (46) (14) (44)
Necrosis 1 (2%)
Lymphoid Nodule, Hemorrhage 1 (2%)
Lymphoid Nodule, Hyperplasia 1 (2%)
Liver (48) (49) (49)
Angiectasis 2 (4%)
Basophilic Focus 2 (4%) 2 (4%)
Clear Cell Focus 1 (2%)
Congestion 1 (2%)
Cyst 2 (4%)
Eosinophilic Focus 2 (4%)
Fatty Change 1 (2%)
Fatty Change, Diffuse 1 (2%) 1 (2%)
Fatty Change, Focal 2 (4%) 8 (16%) 2 (4%)
Hematopoietic Cell Proliferation 1 (2%) 7 (14%) 7 (14%)
Mineralization 2 (4%)
Necrosis 10 (21%) 4 (8%) 4 (8%)
Necrosis, Coagulative 1 (2%) 1 (2%)
Bile Duct, Hyperplasia, Cystic 1 (2%)
Mesentery (3) (5) (9)
Hemorrhage 1 (20%)
Inflammation, Acute 1 (33%) 3 (60%) 8 (89%)
Inflammation, Chronic Active 1 (33%)
Fat, Inflammation, Chronic Active 1 (33%) 1 (20%)
Fat, Necrosis 1 (33%) 1 (20%) 1 (11%)
Pancreas (48) (19) (47)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05030-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC PROBENECID Date: 09/04/94
Route: GAVAGE Time: 15:09:51
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE .1G/KG .4G/KG
FEMALE LF HF
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Acinus, Atrophy 1 (2%)
Acinus, Hyperplasia 2 (4%)
Salivary Glands (45) (15) (49)
Mineralization 1 (2%)
Stomach, Forestomach (47) (49) (49)
Acanthosis 11 (23%) 11 (22%) 7 (14%)
Hyperkeratosis 14 (30%) 12 (24%) 9 (18%)
Inflammation, Acute 2 (4%) 1 (2%)
Inflammation, Chronic Active 1 (2%) 2 (4%)
Mineralization 1 (2%)
Necrosis 2 (4%) 6 (12%) 1 (2%)
Stomach, Glandular (46) (48) (48)
Dilatation 1 (2%)
Hyperplasia 5 (11%) 14 (29%) 1 (2%)
Inflammation, Acute 1 (2%)
Inflammation, Chronic Active 1 (2%) 2 (4%) 1 (2%)
Necrosis 1 (2%)
Pigmentation 1 (2%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (48) (15) (49)
Cardiomyopathy 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland (48) (14) (49)
Capsule, Hyperplasia 38 (79%) 7 (50%) 43 (88%)
Adrenal Gland, Cortex (48) (14) (49)
Accessory Adrenal Cortical Nodule 1 (2%)
Cyst 1 (2%)
Hematopoietic Cell Proliferation 2 (4%) 1 (7%) 5 (10%)
Hyperplasia 37 (77%) 7 (50%) 39 (80%)
Hypertrophy 1 (2%) 1 (2%)
Adrenal Gland, Medulla (44) (13) (44)
Degeneration 1 (2%)
Pituitary Gland (41) (13) (38)
Angiectasis 1 (2%)
Pars Distalis, Angiectasis 3 (7%) 5 (13%)
Pars Distalis, Cyst 1 (3%)
Pars Distalis, Hyperplasia 13 (32%) 2 (15%) 8 (21%)
Pars Distalis, Hyperplasia, Focal 1 (2%) 1 (3%)
Pars Intermedia, Hyperplasia 1 (3%)
Thyroid Gland (48) (48) (48)
Infiltration Cellular, Lymphocyte 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05030-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC PROBENECID Date: 09/04/94
Route: GAVAGE Time: 15:09:51
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE .1G/KG .4G/KG
FEMALE LF HF
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Follicle, Cyst 1 (2%) 1 (2%)
Follicular Cell, Hyperplasia 1 (2%) 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Ovary (47) (48) (50)
Abscess 1 (2%) 3 (6%) 11 (22%)
Angiectasis 2 (4%)
Cyst 4 (9%) 4 (8%) 9 (18%)
Degeneration, Cystic 12 (26%) 9 (19%) 7 (14%)
Hemorrhage 2 (4%) 1 (2%) 2 (4%)
Hyperplasia 1 (2%) 1 (2%)
Inflammation, Acute 1 (2%)
Mineralization 2 (4%) 1 (2%)
Pigmentation 3 (6%) 1 (2%)
Bilateral, Abscess 4 (8%)
Uterus (48) (30) (50)
Angiectasis 1 (2%)
Cyst 1 (3%)
Hemorrhage 1 (2%) 1 (2%)
Hyperplasia 1 (2%)
Inflammation, Acute 1 (2%) 2 (7%) 2 (4%)
Mineralization 1 (2%)
Necrosis 1 (3%) 1 (2%)
Endometrium, Hyperplasia 36 (75%) 14 (47%) 33 (66%)
Vagina (1) (1)
Inflammation, Chronic Active 1 (100%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (48) (14) (49)
Myelofibrosis 13 (27%) 5 (10%)
Lymph Node (43) (26) (45)
Hematopoietic Cell Proliferation 1 (2%)
Lumbar, Angiectasis 1 (4%)
Lumbar, Hematopoietic Cell Proliferation 3 (12%) 6 (13%)
Lumbar, Infiltration Cellular, Plasma Cell 1 (2%) 8 (31%) 5 (11%)
Lumbar, Infiltration Cellular, Histiocyte 1 (4%)
Mandibular, Hematopoietic Cell Proliferation 2 (4%)
Mandibular, Infiltration Cellular, Plasma
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05030-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC PROBENECID Date: 09/04/94
Route: GAVAGE Time: 15:09:51
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE .1G/KG .4G/KG
FEMALE LF HF
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Cell 1 (2%)
Mediastinal, Hematopoietic Cell Proliferation 1 (2%)
Mediastinal, Infiltration Cellular, Plasma
Cell 2 (8%) 1 (2%)
Pancreatic, Angiectasis 1 (2%)
Pancreatic, Hematopoietic Cell Proliferation 1 (4%) 2 (4%)
Renal, Hematopoietic Cell Proliferation 2 (8%) 4 (9%)
Renal, Hemorrhage 1 (4%)
Renal, Infiltration Cellular, Plasma Cell 1 (2%) 8 (31%) 3 (7%)
Renal, Infiltration Cellular, Histiocyte 1 (4%)
Lymph Node, Mesenteric (41) (20) (44)
Angiectasis 4 (10%) 4 (9%)
Depletion Lymphoid 1 (2%)
Hematopoietic Cell Proliferation 3 (7%) 2 (10%) 7 (16%)
Hemorrhage 1 (5%)
Infiltration Cellular, Plasma Cell 1 (2%) 3 (15%) 2 (5%)
Infiltration Cellular, Histiocyte 1 (5%)
Necrosis 1 (2%)
Spleen (48) (25) (49)
Angiectasis 1 (2%)
Atrophy 1 (2%)
Hematopoietic Cell Proliferation 24 (50%) 15 (60%) 32 (65%)
Hemorrhage 1 (4%)
Necrosis 1 (2%)
Thrombosis 1 (4%)
Lymphoid Follicle, Hyperplasia 2 (4%) 3 (6%)
Thymus (42) (12) (42)
Angiectasis 1 (2%)
Depletion Lymphoid 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (46) (16) (48)
Bacterium 1 (2%)
Cyst Epithelial Inclusion 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05030-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC PROBENECID Date: 09/04/94
Route: GAVAGE Time: 15:09:51
____________________________________________________________________________________________________________________________________
B6C3F1 MICE FEMALE VEHICLE .1G/KG .4G/KG
FEMALE LF HF
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (49) (23) (49)
Bacterium 2 (4%)
Congestion 1 (2%)
Hemorrhage 4 (8%) 1 (4%) 1 (2%)
Infiltration Cellular, Histiocyte 2 (4%) 1 (4%) 1 (2%)
Inflammation, Acute 4 (8%)
Inflammation, Chronic Active 2 (9%)
Pleura, Abscess 2 (9%)
Pleura, Inflammation, Acute 2 (4%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Harderian Gland (1) (2)
Mineralization 1 (100%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (48) (19) (49)
Cyst 1 (2%)
Degeneration 1 (2%)
Hydronephrosis 1 (2%)
Inflammation, Acute 1 (2%)
Inflammation, Chronic Active 1 (5%)
Cortex, Mineralization 1 (2%) 1 (5%) 1 (2%)
Papilla, Mineralization 1 (2%) 2 (4%)
Renal Tubule, Pigmentation 1 (2%)
Renal Tubule, Regeneration 1 (2%)
Urinary Bladder (44) (13) (47)
Edema 1 (2%)
Infiltration Cellular, Polymorphonuclear 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05030-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC PROBENECID Date: 09/04/94
Route: GAVAGE Time: 15:09:51
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE .1G/KG .4G/KG
MALE LM HM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50
Early Deaths
Dead 7 6 13
Moribund 5 19 13
Gavage Death 2
Survivors
Terminal Sacrifice 38 23 24
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Gallbladder (46) (40) (40)
Hemorrhage 1 (2%)
Intestine Large (49) (49) (47)
Anus, Inflammation, Chronic Active 1 (2%)
Anus, Necrosis 1 (2%)
Intestine Large, Colon (49) (49) (47)
Lymphoid Nodule, Hyperplasia 2 (4%)
Intestine Large, Rectum (48) (45) (40)
Inflammation, Acute 1 (3%)
Necrosis 1 (3%)
Intestine Small, Duodenum (48) (45) (42)
Necrosis 1 (2%)
Intestine Small, Ileum (48) (44) (43)
Epithelium, Hyperplasia 1 (2%)
Lymphoid Nodule, Hyperplasia 1 (2%) 2 (5%)
Intestine Small, Jejunum (48) (43) (39)
Lymphoid Nodule, Hyperplasia 1 (2%)
Liver (50) (50) (50)
Angiectasis 1 (2%)
Clear Cell Focus 2 (4%)
Cyst 1 (2%) 1 (2%)
Fatty Change, Focal 2 (4%) 1 (2%) 2 (4%)
Hematopoietic Cell Proliferation 1 (2%) 1 (2%)
Hemorrhage 1 (2%)
Mineralization 3 (6%)
Necrosis 4 (8%) 8 (16%) 14 (28%)
Necrosis, Coagulative 1 (2%)
Pigmentation 2 (4%)
Mesentery (1) (2) (1)
Fat, Inflammation, Chronic Active 1 (100%)
Fat, Mineralization 1 (100%)
Fat, Necrosis 2 (100%)
Pancreas (47) (50) (50)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05030-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC PROBENECID Date: 09/04/94
Route: GAVAGE Time: 15:09:51
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE .1G/KG .4G/KG
MALE LM HM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Acinus, Atrophy 1 (2%)
Acinus, Hypertrophy 2 (4%)
Stomach (49) (50) (48)
Submucosa, Inflammation, Chronic Active 1 (2%)
Stomach, Forestomach (49) (50) (48)
Acanthosis 2 (4%) 3 (6%) 7 (15%)
Acanthosis, Focal 1 (2%) 1 (2%)
Hyperkeratosis 7 (14%) 5 (10%) 10 (21%)
Inflammation, Acute 1 (2%)
Inflammation, Chronic Active 2 (4%)
Necrosis 3 (6%) 4 (8%)
Stomach, Glandular (47) (50) (45)
Hyperplasia 2 (4%) 1 (2%) 1 (2%)
Inflammation, Chronic Active 3 (6%)
Mineralization 1 (2%)
Necrosis 2 (4%) 1 (2%)
Pigmentation 1 (2%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Heart (49) (50) (50)
Cardiomyopathy 1 (2%)
Inflammation, Acute 2 (4%)
Inflammation, Chronic Active 1 (2%) 1 (2%)
Mineralization 2 (4%)
Thrombosis 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland (48) (50) (49)
Capsule, Hyperplasia 23 (48%) 22 (44%) 30 (61%)
Capsule, Hyperplasia, Focal 1 (2%) 2 (4%)
Adrenal Gland, Cortex (48) (50) (49)
Accessory Adrenal Cortical Nodule 1 (2%) 1 (2%) 1 (2%)
Hemorrhage 1 (2%)
Hyperplasia 22 (46%) 23 (46%) 28 (57%)
Hypertrophy 1 (2%)
Adrenal Gland, Medulla (48) (44) (46)
Hyperplasia 7 (15%) 10 (23%) 6 (13%)
Islets, Pancreatic (47) (49) (49)
Hyperplasia 1 (2%) 2 (4%)
Parathyroid Gland (31) (35) (28)
Cyst 1 (4%)
Hyperplasia 1 (4%)
Pituitary Gland (38) (44) (44)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 05030-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC PROBENECID Date: 09/04/94
Route: GAVAGE Time: 15:09:51
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE .1G/KG .4G/KG
MALE LM HM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Pars Distalis, Cyst 1 (2%)
Pars Distalis, Hyperplasia 1 (2%) 1 (2%)
Pars Distalis, Hyperplasia, Adenomatous 1 (3%)
Thyroid Gland (48) (50) (47)
Cyst 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Preputial Gland (12) (15) (21)
Dilatation 5 (42%) 3 (20%) 8 (38%)
Inflammation, Acute 1 (8%) 2 (10%)
Inflammation, Chronic 1 (7%)
Inflammation, Chronic Active 4 (33%) 4 (27%) 5 (24%)
Necrosis 4 (33%) 4 (27%) 4 (19%)
Prostate (48) (46) (50)
Inflammation, Acute 2 (4%) 2 (4%) 4 (8%)
Inflammation, Chronic Active 2 (4%)
Necrosis 1 (2%)
Epithelium, Hyperplasia 2 (4%)
Seminal Vesicle (49) (50) (50)
Hemorrhage 1 (2%)
Inflammation, Acute 1 (2%) 2 (4%)
Inflammation, Chronic Active 1 (2%)
Testes (49) (50) (50)
Atrophy 1 (2%)
Spermatocele 1 (2%)
Interstitial Cell, Hyperplasia 1 (2%)
Seminiferous Tubule, Atrophy 1 (2%) 2 (4%) 2 (4%)
Seminiferous Tubule, Mineralization 1 (2%) 2 (4%) 2 (4%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (49) (50) (50)
Angiectasis 1 (2%)
Lymph Node (44) (45) (42)
Axillary, Infiltration Cellular, Plasma Cell 1 (2%) 2 (4%) 1 (2%)
Axillary, Infiltration Cellular, Lymphocyte 1 (2%)
Inguinal, Infiltration Cellular, Lymphocyte 1 (2%)
Lumbar, Hematopoietic Cell Proliferation 3 (7%)
Lumbar, Hyperplasia, Plasma Cell 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 05030-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC PROBENECID Date: 09/04/94
Route: GAVAGE Time: 15:09:51
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE .1G/KG .4G/KG
MALE LM HM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Lumbar, Infiltration Cellular, Plasma Cell 2 (5%) 7 (16%) 2 (5%)
Lumbar, Infiltration Cellular, Lymphocyte 1 (2%)
Lumbar, Infiltration Cellular, Histiocyte 1 (2%)
Lumbar, Inflammation, Acute 1 (2%)
Mandibular, Necrosis 1 (2%)
Mediastinal, Angiectasis 1 (2%)
Mediastinal, Hematopoietic Cell Proliferation 1 (2%)
Mediastinal, Infiltration Cellular,
Histiocyte 1 (2%)
Pancreatic, Hematopoietic Cell Proliferation 1 (2%)
Renal, Hematopoietic Cell Proliferation 1 (2%)
Renal, Infiltration Cellular, Plasma Cell 1 (2%) 2 (4%) 3 (7%)
Renal, Infiltration Cellular, Histiocyte 2 (4%)
Lymph Node, Mesenteric (44) (42) (38)
Angiectasis 20 (45%) 19 (45%) 14 (37%)
Hematopoietic Cell Proliferation 4 (9%) 6 (14%) 9 (24%)
Necrosis 1 (3%)
Spleen (49) (50) (48)
Angiectasis 2 (4%)
Atrophy 1 (2%)
Depletion Lymphoid 2 (4%) 1 (2%)
Fibrosis 1 (2%)
Hematopoietic Cell Proliferation 19 (39%) 25 (50%) 29 (60%)
Hyperplasia, Lymphoid 1 (2%)
Necrosis 1 (2%)
Lymphoid Follicle, Hyperplasia 1 (2%)
Thymus (47) (36) (36)
Atrophy 1 (2%) 1 (3%) 1 (3%)
Depletion Lymphoid 4 (11%) 2 (6%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Skin (47) (49) (48)
Hemorrhage 1 (2%)
Hyperplasia, Basal Cell 1 (2%)
Inflammation, Acute 1 (2%)
Inflammation, Chronic Active 1 (2%)
Necrosis 1 (2%) 2 (4%)
Inguinal, Fungus 1 (2%)
Inguinal, Inflammation, Chronic Active 1 (2%)
Inguinal, Necrosis 1 (2%)
Prepuce, Acanthosis 1 (2%)
Prepuce, Hemorrhage 1 (2%) 1 (2%)
Prepuce, Inflammation, Acute 1 (2%)
Prepuce, Inflammation, Chronic Active 2 (4%) 1 (2%)
Prepuce, Necrosis 2 (4%) 3 (6%) 2 (4%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 05030-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC PROBENECID Date: 09/04/94
Route: GAVAGE Time: 15:09:51
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE .1G/KG .4G/KG
MALE LM HM
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - CONT
Subcutaneous Tissue, Mineralization 1 (2%)
Subcutaneous Tissue, Necrosis 1 (2%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Bone (49) (50) (50)
Joint, Hyperostosis 1 (2%)
Tarsal, Hyperostosis 35 (71%) 33 (66%) 36 (72%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
None
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (49) (50) (50)
Bacterium 1 (2%)
Congestion 2 (4%) 2 (4%)
Hemorrhage 6 (12%) 2 (4%) 4 (8%)
Infiltration Cellular, Histiocyte 2 (4%) 1 (2%) 2 (4%)
Inflammation, Acute 2 (4%) 2 (4%) 2 (4%)
Necrosis 1 (2%)
Pigmentation 1 (2%)
Alveolar Epithelium, Hyperplasia 3 (6%) 2 (4%)
Nose (40) (45) (43)
Edema 1 (3%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
None
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (49) (50) (50)
Atrophy 1 (2%)
Bacterium 1 (2%)
Casts Protein 3 (6%) 4 (8%)
Congestion 1 (2%) 1 (2%)
Glomerulosclerosis 4 (8%)
Hydronephrosis 1 (2%) 1 (2%)
Inflammation, Acute 4 (8%) 1 (2%)
Inflammation, Chronic 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 05030-02 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC PROBENECID Date: 09/04/94
Route: GAVAGE Time: 15:09:51
____________________________________________________________________________________________________________________________________
B6C3F1 MICE MALE VEHICLE .1G/KG .4G/KG
MALE LM HM
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Inflammation, Chronic Active 1 (2%) 1 (2%)
Cortex, Mineralization 16 (33%) 4 (8%) 9 (18%)
Papilla, Mineralization 2 (4%) 3 (6%)
Papilla, Necrosis 1 (2%) 2 (4%) 1 (2%)
Renal Tubule, Casts Protein 1 (2%) 1 (2%)
Renal Tubule, Regeneration 1 (2%) 4 (8%)
Urinary Bladder (48) (49) (47)
Calculus Micro Observation Only 1 (2%) 2 (4%) 2 (4%)
Inflammation, Acute 2 (4%) 3 (6%)
Inflammation, Chronic Active 2 (4%)
Mineralization 1 (2%)
Necrosis 3 (6%) 1 (2%)
Transitional Epithelium, Hyperplasia 2 (4%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 12
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