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TR 395 Mouse Pathology Tables

NTP Experiment-Test: 05030-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             PROBENECID                                        Date: 04/29/97
Route: GAVAGE                                                                                                     Time: 15:49:50




       Facility:  TSI Mason Research

       Chemical CAS #:  000057669

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All






































                                                              Page   1

NTP Experiment-Test: 05030-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             PROBENECID                                        Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 15:49:50  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 0| 7| 7| 7| 7| 7| 7| 7| 6| 6| 0| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5|             
                             DAY ON TEST   | 2| 3| 3| 2| 0| 3| 3| 3| 8| 1| 1| 3| 3| 4| 1| 3| 3| 3| 0| 6| 3| 3| 3| 3| 9|             
                                           | 9| 6| 6| 2| 9| 2| 2| 2| 7| 2| 3| 2| 2| 8| 2| 5| 2| 6| 4| 0| 5| 5| 2| 2| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     FEMALE                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             |    +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  A  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Large                         |    +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         |    +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Necrosis                             |          2                                                               |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Necrosis                             |          2                                                               |             
      Lymphoid Nodule, Hemorrhage          |                                                 2                        |             
                                            __________________________________________________________________________|             
   Liver                                   |    +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                                             3            |             
      Clear Cell Focus                     |                                                          3               |             
      Fatty Change, Diffuse                |                                                                          |             
      Fatty Change, Focal                  |                                                                          |             
      Hematopoietic Cell Proliferation     |                                           2                              |             
      Mineralization                       |             2                                                            |             
      Necrosis                             |    1  1  1  2           2        1  1              1                     |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                        +  +                              |             
      Inflammation, Acute                  |                                        3                                 |             
      Inflammation, Chronic Active         |                                           4                              |             
      Fat, Inflammation, Chronic Active    |                                                                          |             
      Fat, Necrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Hyperplasia                  |                            2                                             |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 |    +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |       1  1                             1  2  2                       1   |             
      Hyperkeratosis                       |       2  3                          2  2  3  3                    2  2   |             
      Inflammation, Acute                  |                                                                          |             
      Mineralization                       |                                                                      1   |             
      Necrosis                             |                                              2                           |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                                                          |             
      Hyperplasia                          |                                     2        3                    2      |             
      Inflammation, Chronic Active         |                                              2                           |             
      Pigmentation                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05030-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             PROBENECID                                        Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 15:49:50  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 0| 7| 7| 7| 7| 7| 7| 7| 6| 6| 0| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5|             
                             DAY ON TEST   | 2| 3| 3| 2| 0| 3| 3| 3| 8| 1| 1| 3| 3| 4| 1| 3| 3| 3| 0| 6| 3| 3| 3| 3| 9|             
                                           | 9| 6| 6| 2| 9| 2| 2| 2| 7| 2| 3| 2| 2| 8| 2| 5| 2| 6| 4| 0| 5| 5| 2| 2| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     FEMALE                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |    +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |    +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Capsule, Hyperplasia                 |       2  2  1  2  2  2  2  2     2  2  2  3     2  2  2        2     2   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |    +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                      X                                                   |             
      Cyst                                 |                                                                X         |             
      Hematopoietic Cell Proliferation     |                                           1                              |             
      Hyperplasia                          |       2  2  1  2     2  2  2     2  2  2  3     2  2  2        2     2   |             
      Hypertrophy                          |                                                             2            |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |    +  +     M  +  +  +  +  +  A  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration                         |                                                                1         |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    +  +  M  M  +  +  +  M  +  M  M  +  +  +  M  +  M  +  +  +  +  +  M  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |    +  +  M  M  +  +  +  M  +  A  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                      2                                                   |             
      Pars Distalis, Angiectasis           |                                                                      1   |             
      Pars Distalis, Hyperplasia, Focal    |                                                                          |             
      Pars Distalis, Hyperplasia           |       2              3                    2              2  1        2   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |    +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicle, Cyst                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   |    +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Abscess                              |                                        4                                 |             
      Cyst                                 |                   X                                            X         |             
      Degeneration, Cystic                 |    2  3              2     3     3              3     3                  |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia                          |                                                                          |             
      Mineralization                       |                                                                          |             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  |    +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Hyperplasia                          |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Endometrium, Hyperplasia             |    3  3        3  2  2  2  2     3  3  2  2  3  3  3  4        2  3  2   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |    +  +        +  +  +           +  +        +  +  +        +  +  +  +   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05030-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             PROBENECID                                        Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 15:49:50  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 0| 7| 7| 7| 7| 7| 7| 7| 6| 6| 0| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5|             
                             DAY ON TEST   | 2| 3| 3| 2| 0| 3| 3| 3| 8| 1| 1| 3| 3| 4| 1| 3| 3| 3| 0| 6| 3| 3| 3| 3| 9|             
                                           | 9| 6| 6| 2| 9| 2| 2| 2| 7| 2| 3| 2| 2| 8| 2| 5| 2| 6| 4| 0| 5| 5| 2| 2| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     FEMALE                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Myelofibrosis                        |    3           3  3  2  2        3  2                                    |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lumbar, Infiltration Cellular,       |                                                                          |             
          Plasma Cell                      |                                        2                                 |             
      Mandibular, Infiltration Cellular,   |                                                                          |             
           Plasma Cell                     |                                           3                              |             
      Renal, Infiltration Cellular, Plasma |                                                                          |             
          Cell                             |                                        3                                 |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |    +  +  +  +  +  M  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                      4  1           3                                    |             
      Hematopoietic Cell Proliferation     |                         2                 2                              |             
      Infiltration Cellular, Plasma Cell   |                                           3                              |             
                                            __________________________________________________________________________|             
   Spleen                                  |    +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |       2     2  2           2     2     3  3  2  2  1                 2   |             
      Necrosis                             |          2                                                               |             
      Lymphoid Follicle, Hyperplasia       |                                     2                                    |             
                                            __________________________________________________________________________|             
   Thymus                                  |    +  +  +  +  +  +  +  +  +  A  M  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Angiectasis                          |                                                                   2      |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    M  +  +  M  M  M  M  M  +  M  M  +  +  +  M  +  +  +  +  M  M  M  M  +|             
                                            __________________________________________________________________________|             
   Skin                                    |    +  +  +  +  +  +  +  +  +  A  M  +  +  +  +  +  +  +  +  +  +  +  M  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +  +  +  M  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hemorrhage                           |                                           1                    1         |             
      Infiltration Cellular, Histiocyte    |    2                                                                     |             
                                            __________________________________________________________________________|             
   Nose                                    |    +  +  +  M  M  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |    +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                      X                                                   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05030-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             PROBENECID                                        Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 15:49:50  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 0| 7| 7| 7| 7| 7| 7| 7| 6| 6| 0| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5|             
                             DAY ON TEST   | 2| 3| 3| 2| 0| 3| 3| 3| 8| 1| 1| 3| 3| 4| 1| 3| 3| 3| 0| 6| 3| 3| 3| 3| 9|             
                                           | 9| 6| 6| 2| 9| 2| 2| 2| 7| 2| 3| 2| 2| 8| 2| 5| 2| 6| 4| 0| 5| 5| 2| 2| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     FEMALE                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Degeneration                         |                                                                          |             
      Hydronephrosis                       |          2                                                               |             
      Cortex, Mineralization               |                                                                          |             
      Papilla, Mineralization              |                            1                                             |             
      Renal Tubule, Pigmentation           |                                                                          |             
      Renal Tubule, Regeneration           |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Edema                                |                                           1                              |             
      Infiltration Cellular,               |                                                                          |             
          Polymorphonuclear                |                                           2                              |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05030-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             PROBENECID                                        Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 15:49:50  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5|            |
                             DAY ON TEST   | 3| 2| 0| 8| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3|            |
                                           | 5| 1| 9| 7| 3| 5| 5| 5| 5| 5| 5| 5| 5| 6| 5| 5| 5| 5| 5| 5| 5| 5| 6| 0| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     FEMALE                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +|  44        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  47        |
      Necrosis                             |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  46        |
      Necrosis                             |                                                                          |      1  2.0|
      Lymphoid Nodule, Hemorrhage          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Basophilic Focus                     |                                                                X         |      2  3.0|
      Clear Cell Focus                     |                                                                          |      1  3.0|
      Fatty Change, Diffuse                |                                                                      2   |      1  2.0|
      Fatty Change, Focal                  |                         1                 2                              |      2  1.5|
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
      Mineralization                       |                         1                                                |      2  1.5|
      Necrosis                             |                                                                   2  1   |     10  1.3|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                         +|   3        |
      Inflammation, Acute                  |                                                                          |      1  3.0|
      Inflammation, Chronic Active         |                                                                          |      1  4.0|
      Fat, Inflammation, Chronic Active    |                                                                         3|      1  3.0|
      Fat, Necrosis                        |                                                                         2|      1  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Acinus, Hyperplasia                  |    1                                                                     |      2  1.5|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  M  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|  45        |
      Mineralization                       |                1                                                         |      1  1.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|  47        |
      Acanthosis                           |       2  2                    3        2                 2               |     11  1.7|
      Hyperkeratosis                       |       3  2                    2        2     3           3               |     14  2.4|
      Inflammation, Acute                  |                               2        2                                 |      2  2.0|
      Mineralization                       |                                                                          |      1  1.0|
      Necrosis                             |                                        1                                 |      2  1.5|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  M  A  +  +  +  +  +  +  +  +  +  +|  46        |
      Dilatation                           |                   2                                                      |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   6                                                               
NTP Experiment-Test: 05030-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             PROBENECID                                        Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 15:49:50  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5|            |
                             DAY ON TEST   | 3| 2| 0| 8| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3|            |
                                           | 5| 1| 9| 7| 3| 5| 5| 5| 5| 5| 5| 5| 5| 6| 5| 5| 5| 5| 5| 5| 5| 5| 6| 0| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     FEMALE                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia                          |          2                                                        2      |      5  2.2|
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Pigmentation                         |          2                                                               |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Cardiomyopathy                       |                                                             1            |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Capsule, Hyperplasia                 | 2  2  2  2  2  2  2  2  2  2  2  2  2  3        2     2  2  3  2  2  2   |     38  2.1|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Accessory Adrenal Cortical Nodule    |                                                                          |      1     |
      Cyst                                 |                                                                          |      1     |
      Hematopoietic Cell Proliferation     |                                                                         2|      2  1.5|
      Hyperplasia                          | 2  2  2  2  2  2  2  2  2  2  2  2  2  3        2     2  2  3  2  2  2   |     37  2.1|
      Hypertrophy                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|  44        |
      Degeneration                         |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  +  M  +  M  M  +  M  +  +  M  M  M  +  +  +  +  +  M  +  +  M  +  M  M|  29        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  M  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  41        |
      Angiectasis                          |                                                                          |      1  2.0|
      Pars Distalis, Angiectasis           |                      2                                         2         |      3  1.7|
      Pars Distalis, Hyperplasia, Focal    |                                                       2                  |      1  2.0|
      Pars Distalis, Hyperplasia           |          2           3     2              2     2  1     2               |     13  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Follicle, Cyst                       |                               2                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                         +                                                |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Abscess                              |                                                                          |      1  4.0|
      Cyst                                 |                      X           X                                       |      4     |
      Degeneration, Cystic                 |       3                 2     3                    4        3            |     12  2.8|
      Hemorrhage                           |       4     4                                                            |      2  4.0|
      Hyperplasia                          |                               3                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   7                                                               
NTP Experiment-Test: 05030-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             PROBENECID                                        Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 15:49:50  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5|            |
                             DAY ON TEST   | 3| 2| 0| 8| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3|            |
                                           | 5| 1| 9| 7| 3| 5| 5| 5| 5| 5| 5| 5| 5| 6| 5| 5| 5| 5| 5| 5| 5| 5| 6| 0| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     FEMALE                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Mineralization                       |                               1                          2               |      2  1.5|
      Pigmentation                         |                      2        2                          2               |      3  2.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hemorrhage                           |                                                                      2   |      1  2.0|
      Hyperplasia                          |             2                                                            |      1  2.0|
      Inflammation, Acute                  |                                                                1         |      1  1.0|
      Endometrium, Hyperplasia             | 2  2  2  3     2  3  2  2     2  2  3  2     2     2  3  3     2  2      |     36  2.4|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   | +              +  +  +  +  +  +     +  +     +     +  +  +  +  +  +      |  30        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Myelofibrosis                        |    2              2              2  3                       3     2      |     13  2.5|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | M  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|  43        |
      Lumbar, Infiltration Cellular,       |                                                                          |            |
          Plasma Cell                      |                                                                          |      1  2.0|
      Mandibular, Infiltration Cellular,   |                                                                          |            |
           Plasma Cell                     |                                                                          |      1  3.0|
      Renal, Infiltration Cellular, Plasma |                                                                          |            |
          Cell                             |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | M  +  +  M  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|  41        |
      Angiectasis                          |                                                 2                        |      4  2.5|
      Hematopoietic Cell Proliferation     |                                                 2                        |      3  2.0|
      Infiltration Cellular, Plasma Cell   |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hematopoietic Cell Proliferation     |       3     2        2  2  2  2  2     2        2  2        2        3  4|     24  2.2|
      Necrosis                             |                                                                          |      1  2.0|
      Lymphoid Follicle, Hyperplasia       |                2                                                         |      2  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  M  +  +  +  M|  42        |
      Angiectasis                          |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  M  +  M  M  M  M  M  M  +  M  +  M  M  +  +  M  +  M  M  M  +  +|  22        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   8                                                               
NTP Experiment-Test: 05030-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             PROBENECID                                        Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 15:49:50  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5|            |
                             DAY ON TEST   | 3| 2| 0| 8| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3|            |
                                           | 5| 1| 9| 7| 3| 5| 5| 5| 5| 5| 5| 5| 5| 6| 5| 5| 5| 5| 5| 5| 5| 5| 6| 0| 9|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     FEMALE                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Congestion                           |                                                             2            |      1  2.0|
      Hemorrhage                           |                                                          1  1            |      4  1.0|
      Infiltration Cellular, Histiocyte    |    3                                                                     |      2  2.5|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  M  M  +|  41        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Cyst                                 |                                                                          |      1     |
      Degeneration                         |                               2                                          |      1  2.0|
      Hydronephrosis                       |                                                                          |      1  2.0|
      Cortex, Mineralization               |                                  2                                       |      1  2.0|
      Papilla, Mineralization              |                                                                          |      1  1.0|
      Renal Tubule, Pigmentation           |                               3                                          |      1  3.0|
      Renal Tubule, Regeneration           |       2                                                                  |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +     +  +  A  +|  44        |
      Edema                                |                                                                          |      1  1.0|
      Infiltration Cellular,               |                                                                          |            |
          Polymorphonuclear                |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   9                                                               
NTP Experiment-Test: 05030-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             PROBENECID                                        Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 15:49:50  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 3| 7| 7| 7| 4| 3|             
                             DAY ON TEST   | 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 0| 9| 3| 3| 3| 3| 3| 3| 3| 3| 8| 4|             
                                           | 1| 1| 1| 1| 7| 1| 1| 1| 1| 1| 1| 1| 1| 6| 5| 2| 2| 2| 1| 7| 2| 2| 1| 8| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    .1 G/KG                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     LF                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +     +  +  M  A  +  +  +  +  A  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Large                         |                                        +  +              +           +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |                                        M  +              +           +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |                                        +  +              +           +  +|             
      Lymphoid Nodule, Hyperplasia         |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |                                        +  M              +           M  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         |                            +           +  +              +           +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |                            +           +  +              +           A  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |                            +           +  +              +           +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |                            +           +  +              +           A  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Fatty Change, Diffuse                |                                                                          |             
      Fatty Change, Focal                  |             1                          1  2     1  1                     |             
      Hematopoietic Cell Proliferation     |                                                                      2   |             
      Necrosis, Coagulative                |                                           2                              |             
      Necrosis                             |                               2                 1                        |             
      Bile Duct, Hyperplasia, Cystic       |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                      +   |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Acute                  |                                                                      3   |             
      Fat, Inflammation, Chronic Active    |                                                                          |             
      Fat, Necrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +     +                    +           +  +              +           +  +|             
                                            __________________________________________________________________________|             
   Salivary Glands                         |                                        +  +              +           +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                               3  3                 2              1      |             
      Hyperkeratosis                       |                               3  3                 2                     |             
      Inflammation, Chronic Active         |                                                    1                     |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |          2                    1  2  2  1     2     1  1           1      |             
      Inflammation, Acute                  |                            2                                             |             
      Inflammation, Chronic Active         |                               2                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |                                        +  +              +           +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |                                        +  +              +           M  +|             
      Capsule, Hyperplasia                 |                                        2                                 |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |                                        +  +              +           M  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  10                                                               
NTP Experiment-Test: 05030-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             PROBENECID                                        Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 15:49:50  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 3| 7| 7| 7| 4| 3|             
                             DAY ON TEST   | 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 0| 9| 3| 3| 3| 3| 3| 3| 3| 3| 8| 4|             
                                           | 1| 1| 1| 1| 7| 1| 1| 1| 1| 1| 1| 1| 1| 6| 5| 2| 2| 2| 1| 7| 2| 2| 1| 8| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    .1 G/KG                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     LF                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hyperplasia                          |                                        2                                 |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |                                        +  +              +           M  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |       +                                +  +              +           +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +        +     +  +  +  +  +     M  M     +     +  M  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |                +                 M     +  +              +     +     +  +|             
      Pars Distalis, Hyperplasia           |                                                                3         |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                                          |             
      Cyst                                 |    X              X     X                                                |             
      Degeneration, Cystic                 |                                     3        4  3  2              3      |             
      Hemorrhage                           |                                                                2         |             
      Hyperplasia                          |                                                    2                     |             
      Mineralization                       |                                                                          |             
      Pigmentation                         |                                                                          |             
      Bilateral, Abscess                   |                                                                      4   |             
                                            __________________________________________________________________________|             
   Oviduct                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +     +     +  +  +           +        +  +              +  +        +  +|             
      Cyst                                 |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Necrosis                             |                   2                                                      |             
      Endometrium, Hyperplasia             | 3                             2           2                 2            |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                        +                                 |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   | +     +        +  +  +  +  +        +        +  +     +     +  +  +      |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |                                        +  +              +           +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |       +  +     +  +        +     +     +  +  +           +           +  +|             
      Lumbar, Angiectasis                  |                                                                          |             
      Lumbar, Hematopoietic Cell           |                                                                          |             
          Proliferation                    |                            2                                             |             
      Lumbar, Infiltration Cellular,       |                                                                          |             
          Plasma Cell                      |                   2                          2                       2   |             
      Lumbar, Infiltration Cellular,       |                                                                          |             
          Histiocyte                       |                   3                                                      |             
      Mediastinal, Infiltration Cellular,  |                                                                          |             
           Plasma Cell                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  11                                                               
NTP Experiment-Test: 05030-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             PROBENECID                                        Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 15:49:50  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 3| 7| 7| 7| 4| 3|             
                             DAY ON TEST   | 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 0| 9| 3| 3| 3| 3| 3| 3| 3| 3| 8| 4|             
                                           | 1| 1| 1| 1| 7| 1| 1| 1| 1| 1| 1| 1| 1| 6| 5| 2| 2| 2| 1| 7| 2| 2| 1| 8| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    .1 G/KG                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     LF                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Pancreatic, Hematopoietic Cell       |                                                                          |             
          Proliferation                    |                                                                          |             
      Renal, Hematopoietic Cell            |                                                                          |             
          Proliferation                    |                                                                          |             
      Renal, Hemorrhage                    |                                                                          |             
      Renal, Infiltration Cellular, Plasma |                                                                          |             
          Cell                             |                                              2                       2   |             
      Renal, Infiltration Cellular,        |                                                                          |             
          Histiocyte                       |                   2                                                      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |       +  +                 +           +  +              +           +  +|             
      Hematopoietic Cell Proliferation     |                                                                      2   |             
      Hemorrhage                           |                            2                                             |             
      Infiltration Cellular, Plasma Cell   |                                                                      2   |             
      Infiltration Cellular, Histiocyte    |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  |       +  +           +     +  +  +     +  +              +           +  +|             
      Hematopoietic Cell Proliferation     |                      3     3  2  2                                   3   |             
      Hemorrhage                           |                                                                          |             
      Thrombosis                           |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  |          +                             +  +              +           +  +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |                                  +     +  +              +           +  M|             
                                            __________________________________________________________________________|             
   Skin                                    |             +                          +  +              +           +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |                                        +  +              +           +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |                                        +  +              +           +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +                    +           +     +  +              +     +     +  +|             
      Hemorrhage                           |                                                                          |             
      Infiltration Cellular, Histiocyte    |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Pleura, Abscess                      |                                                                         4|             
                                            __________________________________________________________________________|             
   Nose                                    |                                        +  M              +           +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +     +     +  +  +  +     +  +  +  +  +  +     +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
      Mineralization                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  12                                                               
NTP Experiment-Test: 05030-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             PROBENECID                                        Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 15:49:50  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 3| 7| 7| 7| 4| 3|             
                             DAY ON TEST   | 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 0| 9| 3| 3| 3| 3| 3| 3| 3| 3| 8| 4|             
                                           | 1| 1| 1| 1| 7| 1| 1| 1| 1| 1| 1| 1| 1| 6| 5| 2| 2| 2| 1| 7| 2| 2| 1| 8| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    .1 G/KG                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     LF                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |       +                 +  +           +  +              +           +  +|             
      Inflammation, Chronic Active         |                                                                      1   |             
      Cortex, Mineralization               |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |                                        +  M              +           +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  13                                                               
NTP Experiment-Test: 05030-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             PROBENECID                                        Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 15:49:50  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 5| 5| 0| 7| 7| 5| 5| 7| 7| 6| 6| 6| 7| 7| 7| 7| 6| 7| 7| 6| 6| 1|            |
                             DAY ON TEST   | 3| 3| 3| 7| 4| 2| 3| 3| 5| 3| 3| 3| 7| 4| 2| 3| 3| 3| 3| 8| 3| 3| 9| 4| 0|            |
                                           | 2| 2| 2| 0| 7| 9| 2| 2| 0| 6| 2| 2| 4| 4| 7| 2| 2| 2| 2| 6| 2| 2| 4| 6| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|      A     |
    .1 G/KG                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     LF                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +     +     +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  A  +|  41        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |          +  +           +  +              +        +  +  +           +  +|  15        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |          +  +           +  +              +        +  +  +           +  +|  14        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |          +  +           +  +              +        +  +  +           +  +|  15        |
      Lymphoid Nodule, Hyperplasia         |                                                                         2|      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |          +  A           +  M              +        +  +  M           +  +|  10        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |          +  A           +  +              +        +  +  +     +     +  +|  16        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |          +  A           +  +              +        +  +  +     +     A  +|  14        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |          +  A           +  +              +        +  +  +     +     +  +|  16        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |          +  A           +  +              +        +  +  +     +     A  +|  14        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Congestion                           |                         3                                                |      1  3.0|
      Fatty Change, Diffuse                |                                                       2                  |      1  2.0|
      Fatty Change, Focal                  |                                        1           2              1      |      8  1.3|
      Hematopoietic Cell Proliferation     |          1  2        2  2           2  2                                 |      7  1.9|
      Necrosis, Coagulative                |                                                                          |      1  2.0|
      Necrosis                             |                                                    2        1            |      4  1.5|
      Bile Duct, Hyperplasia, Cystic       |                                  2                                       |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |          +                    +        +        +                        |   5        |
      Hemorrhage                           |                                                 4                        |      1  4.0|
      Inflammation, Acute                  |          3                             3                                 |      3  3.0|
      Fat, Inflammation, Chronic Active    |                               2                                          |      1  2.0|
      Fat, Necrosis                        |                               3                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                |          +  +           +  +  +           +        +  +  +           +  +|  19        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |          +  +           +  +              +        +  +  +           +  +|  15        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Acanthosis                           |       2           2                          2  2  3  1     2            |     11  2.1|
      Hyperkeratosis                       | 2  1  3                          1           1  2  3  2     2            |     12  2.1|
      Inflammation, Chronic Active         |                                                                          |      1  1.0|
      Necrosis                             |       2           3                          3  2     2     2            |      6  2.3|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  A     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hyperplasia                          | 1  2  2                       2  1                                       |     14  1.5|
      Inflammation, Acute                  |                                                                          |      1  2.0|
      Inflammation, Chronic Active         |    2                                                                     |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |          +  +           +  +              +        +  +  +           +  +|  15        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  14                                                               
NTP Experiment-Test: 05030-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             PROBENECID                                        Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 15:49:50  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 5| 5| 0| 7| 7| 5| 5| 7| 7| 6| 6| 6| 7| 7| 7| 7| 6| 7| 7| 6| 6| 1|            |
                             DAY ON TEST   | 3| 3| 3| 7| 4| 2| 3| 3| 5| 3| 3| 3| 7| 4| 2| 3| 3| 3| 3| 8| 3| 3| 9| 4| 0|            |
                                           | 2| 2| 2| 0| 7| 9| 2| 2| 0| 6| 2| 2| 4| 4| 7| 2| 2| 2| 2| 6| 2| 2| 4| 6| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|      A     |
    .1 G/KG                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     LF                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |          +  +           +  +              +        +  +  +           +  +|  14        |
      Capsule, Hyperplasia                 |          2              2  2              2                          2  2|      7  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |          +  +           +  +              +        +  +  +           +  +|  14        |
      Hematopoietic Cell Proliferation     |                         2                                                |      1  2.0|
      Hyperplasia                          |          2              2  2              2                          2  2|      7  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |          +  +              +              +        +  +  +           +  +|  13        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |          +  A           +  +              +        +  +  +           +  +|  15        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |    +  +  +  M        +  M  +        +     M  +  +  +  M  +  +  +     +  +|  29        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |          M  +           M  M              +           +  +           +  +|  13        |
      Pars Distalis, Hyperplasia           |             2                                                            |      2  2.5|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Follicular Cell, Hyperplasia         |                      2                                                   |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                      +   |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Abscess                              |                      3  4              4                                 |      3  3.7|
      Cyst                                 |                                                       X                  |      4     |
      Degeneration, Cystic                 |       2                             3        2                 3         |      9  2.8|
      Hemorrhage                           |                                                                          |      1  2.0|
      Hyperplasia                          |                                                                          |      1  2.0|
      Mineralization                       |                                              2                           |      1  2.0|
      Pigmentation                         |                                              2                           |      1  2.0|
      Bilateral, Abscess                   |          4  4              4                                             |      4  4.0|
                                            __________________________________________________________________________|____________|
   Oviduct                                 |                            +                                             |   1        |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +     +  +     +     +  +  +     +     +  +     +  +  +  +     +  +  +|  30        |
      Cyst                                 |                                                       X                  |      1     |
      Inflammation, Acute                  |          2              3                                                |      2  2.5|
      Necrosis                             |                                                                          |      1  2.0|
      Endometrium, Hyperplasia             | 2  3     2        2           2     2     3  3     2        2            |     14  2.3|
                                            __________________________________________________________________________|____________|
   Vagina                                  |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   | +  +  +           +  +        +  +              +  +  +     +  +         |  26        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |          +  +           +  +              +        +  +              +  +|  14        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  15                                                               
NTP Experiment-Test: 05030-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             PROBENECID                                        Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 15:49:50  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 5| 5| 0| 7| 7| 5| 5| 7| 7| 6| 6| 6| 7| 7| 7| 7| 6| 7| 7| 6| 6| 1|            |
                             DAY ON TEST   | 3| 3| 3| 7| 4| 2| 3| 3| 5| 3| 3| 3| 7| 4| 2| 3| 3| 3| 3| 8| 3| 3| 9| 4| 0|            |
                                           | 2| 2| 2| 0| 7| 9| 2| 2| 0| 6| 2| 2| 4| 4| 7| 2| 2| 2| 2| 6| 2| 2| 4| 6| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|      A     |
    .1 G/KG                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     LF                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |          +  +        +  +  +        +     +     +  +  +  +        +  +  +|  26        |
      Lumbar, Angiectasis                  |                                                          2               |      1  2.0|
      Lumbar, Hematopoietic Cell           |                                                                          |            |
          Proliferation                    |          2           2                                                   |      3  2.0|
      Lumbar, Infiltration Cellular,       |                                                                          |            |
          Plasma Cell                      |          2  2        2  2  2                                             |      8  2.0|
      Lumbar, Infiltration Cellular,       |                                                                          |            |
          Histiocyte                       |                                                                          |      1  3.0|
      Mediastinal, Infiltration Cellular,  |                                                                          |            |
           Plasma Cell                     |          3              2                                                |      2  2.5|
      Pancreatic, Hematopoietic Cell       |                                                                          |            |
          Proliferation                    |          2                                                               |      1  2.0|
      Renal, Hematopoietic Cell            |                                                                          |            |
          Proliferation                    |                      2                    2                              |      2  2.0|
      Renal, Hemorrhage                    |                                           3                              |      1  3.0|
      Renal, Infiltration Cellular, Plasma |                                                                          |            |
          Cell                             |          2  2        2  2  2        2                                    |      8  2.0|
      Renal, Infiltration Cellular,        |                                                                          |            |
          Histiocyte                       |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |          +  +           +  +              +     +  +  +  +        +  +  +|  20        |
      Hematopoietic Cell Proliferation     |                         2                                                |      2  2.0|
      Hemorrhage                           |                                                                          |      1  2.0|
      Infiltration Cellular, Plasma Cell   |          2              2                                                |      3  2.0|
      Infiltration Cellular, Histiocyte    |                            2                                             |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +        +  +        +  +  +              +        +  +  +     +  +  +  +|  25        |
      Hematopoietic Cell Proliferation     | 2        3  2        2  3  3              2        2     3           2   |     15  2.5|
      Hemorrhage                           |                                           3                              |      1  3.0|
      Thrombosis                           |                                           2                              |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  |          +  +           M  +              +                          +  +|  12        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |          +  +           +  +              +        +  +  +           +  M|  14        |
                                            __________________________________________________________________________|____________|
   Skin                                    |          +  +           +  +              +        +  +  +           +  +|  16        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |          +  +           +  +              +        +  +              +  +|  14        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |          +  +           +  +              +        +  +  +           +  +|  15        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  16                                                               
NTP Experiment-Test: 05030-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             PROBENECID                                        Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 15:49:50  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 5| 5| 0| 7| 7| 5| 5| 7| 7| 6| 6| 6| 7| 7| 7| 7| 6| 7| 7| 6| 6| 1|            |
                             DAY ON TEST   | 3| 3| 3| 7| 4| 2| 3| 3| 5| 3| 3| 3| 7| 4| 2| 3| 3| 3| 3| 8| 3| 3| 9| 4| 0|            |
                                           | 2| 2| 2| 0| 7| 9| 2| 2| 0| 6| 2| 2| 4| 4| 7| 2| 2| 2| 2| 6| 2| 2| 4| 6| 8|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|      A     |
    .1 G/KG                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     LF                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |    +     +  +     +     +  +              +        +  +  +     +  +  +  +|  23        |
      Hemorrhage                           |                                                                2         |      1  2.0|
      Infiltration Cellular, Histiocyte    |                            2                                             |      1  2.0|
      Inflammation, Chronic Active         |             2              2                                             |      2  2.0|
      Pleura, Abscess                      |                         3                                                |      2  3.5|
                                            __________________________________________________________________________|____________|
   Nose                                    |          +  +           +  +              +        +  +              +  +|  13        |
                                            __________________________________________________________________________|____________|
   Trachea                                 |    +  +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|  43        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                   +      |   1        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                   +      |   1        |
      Mineralization                       |                                                                   1      |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |          +  +           +  +              +        +  +  +        +  +  +|  19        |
      Inflammation, Chronic Active         |                                                                          |      1  1.0|
      Cortex, Mineralization               |                                                                   1      |      1  1.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |          +  +           +  +              +        +  +              +  +|  13        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  17                                                               
NTP Experiment-Test: 05030-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             PROBENECID                                        Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 15:49:50  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 4| 4| 4| 7| 7| 7| 7| 5| 7| 7| 7| 6| 5| 7| 7| 7| 7| 5|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 8| 7| 0| 3| 3| 3| 1| 8| 3| 3| 3| 4| 8| 3| 3| 3| 1| 6|             
                                           | 0| 0| 0| 0| 0| 0| 0| 6| 5| 8| 0| 0| 0| 6| 5| 0| 0| 0| 3| 6| 0| 0| 0| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    .4 G/KG                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     HF                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  A  +  +  M  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  A  +  +  +  +  +  +  A  +  +  +  A  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
      Lymphoid Nodule, Hyperplasia         |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  M  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +|             
      Lymphoid Nodule, Hyperplasia         |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     |                   2                                                      |             
      Cyst                                 |                                                                          |             
      Eosinophilic Focus                   |                                                    2                     |             
      Fatty Change, Focal                  |                                                                   2      |             
      Fatty Change                         |                                                                          |             
      Hematopoietic Cell Proliferation     |                      1     1                                   2     2  2|             
      Necrosis, Coagulative                |                                                                          |             
      Necrosis                             |                   2                                                      |             
                                            __________________________________________________________________________|             
   Mesentery                               |                      +  +  +              +                       +     +|             
      Inflammation, Acute                  |                      3  3  2              2                             3|             
      Fat, Necrosis                        |                                                                   2      |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +|             
      Acinus, Atrophy                      |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Acanthosis                           |    2                                                           2         |             
      Hyperkeratosis                       |    3                                                           1         |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic Active         |                                                                2         |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Necrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  18                                                               
NTP Experiment-Test: 05030-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             PROBENECID                                        Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 15:49:50  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 4| 4| 4| 7| 7| 7| 7| 5| 7| 7| 7| 6| 5| 7| 7| 7| 7| 5|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 8| 7| 0| 3| 3| 3| 1| 8| 3| 3| 3| 4| 8| 3| 3| 3| 1| 6|             
                                           | 0| 0| 0| 0| 0| 0| 0| 6| 5| 8| 0| 0| 0| 6| 5| 0| 0| 0| 3| 6| 0| 0| 0| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    .4 G/KG                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     HF                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Capsule, Hyperplasia                 | 2  2  2  2  3  3  2  2  2  2  2  2  2  2  3  2  2  2        2  2  2  2  2|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                      1                                               2   |             
      Hyperplasia                          | 2  2  2  2     3  2  2  2     2  2  2  2  2  2  2  2        2     2  2  2|             
      Hypertrophy                          |                                                             1            |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  M  M  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  M  +  +  +  +  +  M  M  +  +  +  M  M  M  M  M  M  M  +  +  M  +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  M|             
      Pars Distalis, Angiectasis           |    2              1                                                      |             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hyperplasia, Focal    |                                                                2         |             
      Pars Distalis, Hyperplasia           |    2              2                                2        2        2   |             
      Pars Intermedia, Hyperplasia         | 2                                                                        |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |                                                                   1      |             
      Follicle, Cyst                       |                                                                X         |             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                      3  4  4              4              3     4        4|             
      Angiectasis                          |                                                 2                        |             
      Cyst                                 | X                                X                          X            |             
      Degeneration, Cystic                 |                2              2                                          |             
      Hemorrhage                           |                                  4     3                                 |             
      Inflammation, Acute                  |                                                             2            |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                     2                                    |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Acute                  |                      1                                      2            |             
      Mineralization                       |                                                                          |             
      Necrosis                             |                                                                          |             
      Endometrium, Hyperplasia             | 2  4  3  3  3  3           2  2  3  2  2           2        3        2  2|             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   | +     +  +  +  +  +           +  +  +        +  +  +           +  +      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  19                                                               
NTP Experiment-Test: 05030-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             PROBENECID                                        Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 15:49:50  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 4| 4| 4| 7| 7| 7| 7| 5| 7| 7| 7| 6| 5| 7| 7| 7| 7| 5|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 8| 7| 0| 3| 3| 3| 1| 8| 3| 3| 3| 4| 8| 3| 3| 3| 1| 6|             
                                           | 0| 0| 0| 0| 0| 0| 0| 6| 5| 8| 0| 0| 0| 6| 5| 0| 0| 0| 3| 6| 0| 0| 0| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    .4 G/KG                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     HF                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Myelofibrosis                        |             2                                                            |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Lumbar, Hematopoietic Cell           |                                                                          |             
          Proliferation                    |                                                                3     4   |             
      Lumbar, Infiltration Cellular,       |                                                                          |             
          Plasma Cell                      |                            3              2                    2        3|             
      Mandibular, Hematopoietic Cell       |                                                                          |             
          Proliferation                    |                                                                3         |             
      Mediastinal, Hematopoietic Cell      |                                                                          |             
          Proliferation                    |                                                                3         |             
      Mediastinal, Infiltration Cellular,  |                                                                          |             
           Plasma Cell                     |                            3                                             |             
      Pancreatic, Angiectasis              |                                                                          |             
      Pancreatic, Hematopoietic Cell       |                                                                          |             
          Proliferation                    |                                                                          |             
      Renal, Hematopoietic Cell            |                                                                          |             
          Proliferation                    |                                                                3     3   |             
      Renal, Infiltration Cellular, Plasma |                                                                          |             
          Cell                             |                      2                                         2         |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +|             
      Angiectasis                          | 1                             1                                          |             
      Depletion Lymphoid                   |                            2                                             |             
      Hematopoietic Cell Proliferation     |                               2                                3     3  1|             
      Infiltration Cellular, Plasma Cell   |                                                                         2|             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Angiectasis                          |          3                                                               |             
      Atrophy                              |                                                                          |             
      Hematopoietic Cell Proliferation     | 2  2     3           3  3  2  2  2  2     2  2           2  2  3  2  4  3|             
      Lymphoid Follicle, Hyperplasia       |       2                             2                                    |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +|             
      Depletion Lymphoid                   |                         2                                                |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  +  +  M  M  M  +  M  +  M  +  M  M  M  +  +  +  +  M  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bacterium                            |          2                                                               |             
      Cyst Epithelial Inclusion            |                               X                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  20                                                               
NTP Experiment-Test: 05030-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             PROBENECID                                        Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 15:49:50  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 4| 4| 4| 7| 7| 7| 7| 5| 7| 7| 7| 6| 5| 7| 7| 7| 7| 5|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 3| 3| 8| 7| 0| 3| 3| 3| 1| 8| 3| 3| 3| 4| 8| 3| 3| 3| 1| 6|             
                                           | 0| 0| 0| 0| 0| 0| 0| 6| 5| 8| 0| 0| 0| 6| 5| 0| 0| 0| 3| 6| 0| 0| 0| 7| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    .4 G/KG                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     HF                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Bacterium                            |                         1                                                |             
      Hemorrhage                           |                               2                                          |             
      Infiltration Cellular, Histiocyte    |                                                                          |             
      Inflammation, Acute                  |                      1  3  1                                         2   |             
      Pleura, Inflammation, Acute          |                                           3              2               |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                         +|             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                         +|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Inflammation, Acute                  |                                                                          |             
      Cortex, Mineralization               |                                                          1               |             
      Papilla, Mineralization              |                                                          2               |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  21                                                               
NTP Experiment-Test: 05030-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             PROBENECID                                        Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 15:49:50  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 4| 3| 7| 7| 7| 7| 5| 7| 7| 7| 6| 5| 7| 7| 5| 3| 3|            |
                             DAY ON TEST   | 3| 3| 3| 3| 7| 3| 3| 3| 2| 0| 3| 3| 3| 3| 2| 3| 3| 3| 0| 1| 3| 3| 8| 4| 4|            |
                                           | 0| 0| 0| 0| 2| 1| 1| 1| 2| 3| 1| 1| 1| 0| 7| 1| 1| 1| 5| 4| 1| 1| 3| 3| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      A     |
    .4 G/KG                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     HF                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  45        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  44        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  M  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  46        |
      Lymphoid Nodule, Hyperplasia         |                                                             2            |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  44        |
      Lymphoid Nodule, Hyperplasia         |                                                             2            |      1  2.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Angiectasis                          |                1                                                  3      |      2  2.0|
      Basophilic Focus                     |                                                    X                     |      2  2.0|
      Cyst                                 |          X     X                                                         |      2     |
      Eosinophilic Focus                   |                                              X                           |      2  2.0|
      Fatty Change, Focal                  |                1                                                         |      2  1.5|
      Fatty Change                         |                                                                         1|      1  1.0|
      Hematopoietic Cell Proliferation     |                         2                                2               |      7  1.7|
      Necrosis, Coagulative                |                      1                                                   |      1  1.0|
      Necrosis                             |                                     1     2                       2      |      4  1.8|
                                            __________________________________________________________________________|____________|
   Mesentery                               |             +                                         +  +               |   9        |
      Inflammation, Acute                  |             3                                         3  3               |      8  2.8|
      Fat, Necrosis                        |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|  47        |
      Acinus, Atrophy                      |                                                    2                     |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Acanthosis                           | 2        3              2                       3        2               |      7  2.3|
      Hyperkeratosis                       | 2        2     1        2           3                    2           2   |      9  2.0|
      Inflammation, Acute                  | 2                                                                        |      1  2.0|
      Inflammation, Chronic Active         |                                                 2                        |      2  2.0|
      Necrosis                             |          1                                                               |      1  1.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Hyperplasia                          |                2                                                         |      1  2.0|
      Inflammation, Chronic Active         |                            2                                             |      1  2.0|
      Necrosis                             |                                                                      1   |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  22                                                               
NTP Experiment-Test: 05030-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             PROBENECID                                        Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 15:49:50  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 4| 3| 7| 7| 7| 7| 5| 7| 7| 7| 6| 5| 7| 7| 5| 3| 3|            |
                             DAY ON TEST   | 3| 3| 3| 3| 7| 3| 3| 3| 2| 0| 3| 3| 3| 3| 2| 3| 3| 3| 0| 1| 3| 3| 8| 4| 4|            |
                                           | 0| 0| 0| 0| 2| 1| 1| 1| 2| 3| 1| 1| 1| 0| 7| 1| 1| 1| 5| 4| 1| 1| 3| 3| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      A     |
    .4 G/KG                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     HF                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Capsule, Hyperplasia                 | 2  2  2  2     2  2     2     2  2  2  2  2  2  2  2  2  2  2  2  2      |     43  2.1|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hematopoietic Cell Proliferation     |                         2                             2  1               |      5  1.6|
      Hyperplasia                          | 2  2     2     2  2  2  2     2  2  2  2  2  2     2  2  2  2  2  2      |     39  2.0|
      Hypertrophy                          |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  44        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +|  46        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  M  M  +  M  M  +  +  +  M  M  +  M  +  M  +  +  +  +  M  +  +  M  +  +|  28        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  M  M  +  +  +  M  +  +  +  +  +  +  +  +  M  M  +  +  M  M  M|  38        |
      Pars Distalis, Angiectasis           |                      2                       1  2                        |      5  1.6|
      Pars Distalis, Cyst                  |                   X                                                      |      1     |
      Pars Distalis, Hyperplasia, Focal    |                                                                          |      1  2.0|
      Pars Distalis, Hyperplasia           |                   2                 2  2                                 |      8  2.0|
      Pars Intermedia, Hyperplasia         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  1.0|
      Follicle, Cyst                       |                                                                          |      1     |
      Follicular Cell, Hyperplasia         |                                     2                                    |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |          +                                                               |   1        |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Abscess                              |             4           4                             4  4               |     11  3.8|
      Angiectasis                          |                                                    1                     |      2  1.5|
      Cyst                                 | X  X  X                             X     X                             X|      9     |
      Degeneration, Cystic                 |       3        2     3                                3     4            |      7  2.7|
      Hemorrhage                           |                                                                          |      2  3.5|
      Inflammation, Acute                  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  23                                                               
NTP Experiment-Test: 05030-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             PROBENECID                                        Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 15:49:50  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 4| 3| 7| 7| 7| 7| 5| 7| 7| 7| 6| 5| 7| 7| 5| 3| 3|            |
                             DAY ON TEST   | 3| 3| 3| 3| 7| 3| 3| 3| 2| 0| 3| 3| 3| 3| 2| 3| 3| 3| 0| 1| 3| 3| 8| 4| 4|            |
                                           | 0| 0| 0| 0| 2| 1| 1| 1| 2| 3| 1| 1| 1| 0| 7| 1| 1| 1| 5| 4| 1| 1| 3| 3| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      A     |
    .4 G/KG                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     HF                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Hemorrhage                           |                                           3                              |      1  3.0|
      Inflammation, Acute                  |                                                                          |      2  1.5|
      Mineralization                       |                                           2                              |      1  2.0|
      Necrosis                             |                                                          2               |      1  2.0|
      Endometrium, Hyperplasia             | 2  2  2  3     2  2  2     2  2  2  3  2  2  2  2  2     2     2         |     33  2.3|
                                            __________________________________________________________________________|____________|
   Vagina                                  |                                           +                              |   1        |
      Inflammation, Chronic Active         |                                           2                              |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   | +  +     +        +  +                 +                    +  +         |  22        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Myelofibrosis                        |       3  3                                      3  3                     |      5  2.8|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  A|  45        |
      Hematopoietic Cell Proliferation     |                      2                                                   |      1  2.0|
      Lumbar, Hematopoietic Cell           |                                                                          |            |
          Proliferation                    |                   3     2                          2     2               |      6  2.7|
      Lumbar, Infiltration Cellular,       |                                                                          |            |
          Plasma Cell                      |                                                          3               |      5  2.6|
      Mandibular, Hematopoietic Cell       |                                                                          |            |
          Proliferation                    |                         2                                                |      2  2.5|
      Mediastinal, Hematopoietic Cell      |                                                                          |            |
          Proliferation                    |                                                                          |      1  3.0|
      Mediastinal, Infiltration Cellular,  |                                                                          |            |
           Plasma Cell                     |                                                                          |      1  3.0|
      Pancreatic, Angiectasis              |                   3                                                      |      1  3.0|
      Pancreatic, Hematopoietic Cell       |                                                                          |            |
          Proliferation                    |                   2                                      2               |      2  2.0|
      Renal, Hematopoietic Cell            |                                                                          |            |
          Proliferation                    |                   2     2                                                |      4  2.5|
      Renal, Infiltration Cellular, Plasma |                                                                          |            |
          Cell                             |                                                       3                  |      3  2.3|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  A|  44        |
      Angiectasis                          |                   2           1                                          |      4  1.3|
      Depletion Lymphoid                   |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     |                   2           1                          2               |      7  2.0|
      Infiltration Cellular, Plasma Cell   |                                                       3                  |      2  2.5|
      Necrosis                             |                                                    1                     |      1  1.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Angiectasis                          |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  24                                                               
NTP Experiment-Test: 05030-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             PROBENECID                                        Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 15:49:50  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 4| 3| 7| 7| 7| 7| 5| 7| 7| 7| 6| 5| 7| 7| 5| 3| 3|            |
                             DAY ON TEST   | 3| 3| 3| 3| 7| 3| 3| 3| 2| 0| 3| 3| 3| 3| 2| 3| 3| 3| 0| 1| 3| 3| 8| 4| 4|            |
                                           | 0| 0| 0| 0| 2| 1| 1| 1| 2| 3| 1| 1| 1| 0| 7| 1| 1| 1| 5| 4| 1| 1| 3| 3| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      A     |
    .4 G/KG                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     HF                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Atrophy                              |                                                                      3   |      1  3.0|
      Hematopoietic Cell Proliferation     | 2        2     2  3  3  3           2  2  2  3  3  2  4  4        2      |     32  2.5|
      Lymphoid Follicle, Hyperplasia       |                   2                                                      |      3  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  M  M  +|  42        |
      Depletion Lymphoid                   |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  M  +  +  M  +  +  M  M|  32        |
                                            __________________________________________________________________________|____________|
   Skin                                    | M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|  48        |
      Bacterium                            |                                                                          |      1  2.0|
      Cyst Epithelial Inclusion            |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Bacterium                            |                                                       2                  |      2  1.5|
      Hemorrhage                           |                                                                          |      1  2.0|
      Infiltration Cellular, Histiocyte    |                                                             1            |      1  1.0|
      Inflammation, Acute                  |                                                                          |      4  1.8|
      Pleura, Inflammation, Acute          |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                              +                           |   2        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                              +                           |   2        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Acute                  |                         2                                                |      1  2.0|
      Cortex, Mineralization               |                                                                          |      1  1.0|
      Papilla, Mineralization              |                                                    1                     |      2  1.5|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  47        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  25                                                               
NTP Experiment-Test: 05030-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             PROBENECID                                        Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 15:49:50  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 0| 7| 7| 6| 7| 7| 7| 7| 5| 3| 7| 7| 7| 7| 3| 7| 7| 7| 6| 5|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 0| 3| 3| 0| 3| 3| 3| 3| 4| 9| 3| 3| 3| 3| 1| 3| 3| 3| 8| 2|             
                                           | 3| 2| 2| 2| 3| 3| 2| 2| 6| 2| 2| 2| 2| 1| 0| 2| 2| 2| 3| 0| 2| 2| 2| 0| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Hemorrhage                           |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Epithelium, Hyperplasia              |             2                                                            |             
      Lymphoid Nodule, Hyperplasia         |                      3                                                   |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fatty Change, Focal                  |                                                                         1|             
      Necrosis                             |                                        3                          2      |             
                                            __________________________________________________________________________|             
   Mesentery                               |                            +                                             |             
      Fat, Inflammation, Chronic Active    |                            3                                             |             
      Fat, Mineralization                  |                            1                                             |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Acinus, Atrophy                      |                            2                                             |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Submucosa, Inflammation, Chronic     |                                                                          |             
          Active                           |                      1                                                   |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis, Focal                    |                                                                          |             
      Acanthosis                           |          2                                                               |             
      Hyperkeratosis                       |          4                                            3                  |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Hyperplasia                          |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Mineralization                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Capsule, Hyperplasia, Focal          |                                     3                                    |             
      Capsule, Hyperplasia                 | 2        2  2     2           2  2     3  1           2     2            |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  26                                                               
NTP Experiment-Test: 05030-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             PROBENECID                                        Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 15:49:50  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 0| 7| 7| 6| 7| 7| 7| 7| 5| 3| 7| 7| 7| 7| 3| 7| 7| 7| 6| 5|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 0| 3| 3| 0| 3| 3| 3| 3| 4| 9| 3| 3| 3| 3| 1| 3| 3| 3| 8| 2|             
                                           | 3| 2| 2| 2| 3| 3| 2| 2| 6| 2| 2| 2| 2| 1| 0| 2| 2| 2| 3| 0| 2| 2| 2| 0| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Accessory Adrenal Cortical Nodule    |                                                                          |             
      Hyperplasia                          | 2        2  2     2           2  2  2  3  1           2     2            |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                     2     1        2  2                  |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Hyperplasia                          |                            1                                             |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  M  +  +  M  +  +  +  +  +  +  M  M  M  M  M  +  +  +  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  M  M  M  M  M  +  +  +  +|             
      Pars Distalis, Hyperplasia,          |                                                                          |             
          Adenomatous                      |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +           +                             +           +              +  +|             
      Dilatation                           |             2                                                        2  2|             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic Active         | 2           2                                         2                  |             
      Necrosis                             | 1                                                     2                  |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                                                          3               |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                        3                                 |             
      Spermatocele                         |                                                                          |             
      Seminiferous Tubule, Atrophy         |                                                                          |             
      Seminiferous Tubule, Mineralization  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  M|             
      Axillary, Infiltration Cellular,     |                                                                          |             
           Plasma Cell                     |                                                                          |             
      Axillary, Infiltration Cellular,     |                                                                          |             
           Lymphocyte                      |                                                       2                  |             
      Inguinal, Infiltration Cellular,     |                                                                          |             
           Lymphocyte                      |                                                       2                  |             
      Lumbar, Infiltration Cellular,       |                                                                          |             
          Plasma Cell                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  27                                                               
NTP Experiment-Test: 05030-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             PROBENECID                                        Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 15:49:50  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 0| 7| 7| 6| 7| 7| 7| 7| 5| 3| 7| 7| 7| 7| 3| 7| 7| 7| 6| 5|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 0| 3| 3| 0| 3| 3| 3| 3| 4| 9| 3| 3| 3| 3| 1| 3| 3| 3| 8| 2|             
                                           | 3| 2| 2| 2| 3| 3| 2| 2| 6| 2| 2| 2| 2| 1| 0| 2| 2| 2| 3| 0| 2| 2| 2| 0| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Lumbar, Infiltration Cellular,       |                                                                          |             
          Lymphocyte                       |                                                          2               |             
      Mediastinal, Infiltration Cellular,  |                                                                          |             
           Histiocyte                      |                            2                                             |             
      Renal, Infiltration Cellular, Plasma |                                                                          |             
          Cell                             |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  +  M|             
      Angiectasis                          | 2        2        2     3     3  1  2              2  2     2            |             
      Hematopoietic Cell Proliferation     |                                                       2                  |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                            3                                             |             
      Hematopoietic Cell Proliferation     |                2           1     1  1  2  3        1  2  2               |             
      Hyperplasia, Lymphoid                |                                                                      2   |             
      Lymphoid Follicle, Hyperplasia       |          2                                                               |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                      3   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Hyperplasia, Basal Cell              |                                     1                                    |             
      Necrosis                             |                2                                                         |             
      Inguinal, Fungus                     |                                                    3                     |             
      Inguinal, Inflammation, Chronic      |                                                                          |             
          Active                           |                                                    3                     |             
      Inguinal, Necrosis                   |                                                    2                     |             
      Prepuce, Inflammation, Chronic Active|             2                                                            |             
      Prepuce, Necrosis                    |             1                                                            |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Joint, Hyperostosis                  | 2                                                                        |             
      Tarsal, Hyperostosis                 | 3  3  2  3  2     2  2        3  3  2  2  3  3     3  3  2  2  3         |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           | 1                                                     1  1               |             
      Infiltration Cellular, Histiocyte    |                                                                      3   |             
      Inflammation, Acute                  |                                                          2               |             
      Alveolar Epithelium, Hyperplasia     |                      2              2                                    |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  M  +  M  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  M  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  28                                                               
NTP Experiment-Test: 05030-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             PROBENECID                                        Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 15:49:50  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 0| 7| 7| 6| 7| 7| 7| 7| 5| 3| 7| 7| 7| 7| 3| 7| 7| 7| 6| 5|             
                             DAY ON TEST   | 3| 3| 3| 3| 3| 0| 3| 3| 0| 3| 3| 3| 3| 4| 9| 3| 3| 3| 3| 1| 3| 3| 3| 8| 2|             
                                           | 3| 2| 2| 2| 3| 3| 2| 2| 6| 2| 2| 2| 2| 1| 0| 2| 2| 2| 3| 0| 2| 2| 2| 0| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Edema                                |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                       +     +            |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                       +     +            |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bacterium                            |                                                                          |             
      Cortex, Mineralization               | 1     1     1        1  3                    1  1        1           1  2|             
      Papilla, Mineralization              | 1                                                                        |             
      Papilla, Necrosis                    |                                                          1               |             
      Renal Tubule, Regeneration           |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Calculus Micro Observation Only      |                                                                          |             
      Mineralization                       |                1                                                         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  29                                                               
NTP Experiment-Test: 05030-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             PROBENECID                                        Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 15:49:50  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 5| 4|            |
                             DAY ON TEST   | 3| 3| 3| 3| 8| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 7| 1|            |
                                           | 2| 2| 3| 3| 2| 2| 2| 2| 2| 4| 2| 2| 2| 2| 2| 3| 3| 2| 3| 2| 3| 3| 3| 6| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  M  +|  44        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M|  46        |
      Hemorrhage                           |                                                                   3      |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  48        |
      Epithelium, Hyperplasia              |                                                                          |      1  2.0|
      Lymphoid Nodule, Hyperplasia         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Fatty Change, Focal                  |                                  1                                       |      2  1.0|
      Necrosis                             |                                                                2  2      |      4  2.3|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   1        |
      Fat, Inflammation, Chronic Active    |                                                                          |      1  3.0|
      Fat, Mineralization                  |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  47        |
      Acinus, Atrophy                      |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  49        |
      Submucosa, Inflammation, Chronic     |                                                                          |            |
          Active                           |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  49        |
      Acanthosis, Focal                    |                                           4                              |      1  4.0|
      Acanthosis                           |          1                                                               |      2  1.5|
      Hyperkeratosis                       |    2     2                                      1     2     1            |      7  2.1|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  M  +  +  +  +|  47        |
      Hyperplasia                          |                                              1  1                        |      2  1.0|
      Inflammation, Chronic Active         |    2                                         2        1                  |      3  1.7|
      Mineralization                       |             1                                                            |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  49        |
      Cardiomyopathy                       |                   2                                                      |      1  2.0|
      Inflammation, Chronic Active         |                                                                      1   |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  30                                                               
NTP Experiment-Test: 05030-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             PROBENECID                                        Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 15:49:50  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 5| 4|            |
                             DAY ON TEST   | 3| 3| 3| 3| 8| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 7| 1|            |
                                           | 2| 2| 3| 3| 2| 2| 2| 2| 2| 4| 2| 2| 2| 2| 2| 3| 3| 2| 3| 2| 3| 3| 3| 6| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  48        |
      Capsule, Hyperplasia, Focal          |                                                                          |      1  3.0|
      Capsule, Hyperplasia                 |    2     2        2  2  1  1     2  2     2  2  2  2              1      |     23  1.9|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  48        |
      Accessory Adrenal Cortical Nodule    |    X                                                                     |      1     |
      Hyperplasia                          |    2     2        2  2  1        2  2     2  2  2  2                     |     22  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  48        |
      Hyperplasia                          |    2                    3  1                                             |      7  1.9|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|  47        |
      Hyperplasia                          |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  M  M  M  +  M  +  M  +  +  +  M  +  M  +  +  +  +  M  M  +  +  +  M  +|  31        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  M  M  M  +  +  +  +|  38        |
      Pars Distalis, Hyperplasia,          |                                                                          |            |
          Adenomatous                      |                                                    2                     |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  48        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |    +                       +     +        +        +                 +   |  12        |
      Dilatation                           |                                  3                                   3   |      5  2.4|
      Inflammation, Acute                  |                            3                                             |      1  3.0|
      Inflammation, Chronic Active         |                                                                      3   |      4  2.3|
      Necrosis                             |    3                                               3                     |      4  2.3|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  48        |
      Inflammation, Acute                  |                                                                         3|      2  3.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  49        |
      Hemorrhage                           |                                                                         2|      1  2.0|
      Inflammation, Acute                  |                                                                         2|      1  2.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  49        |
      Atrophy                              |                                                                          |      1  3.0|
      Spermatocele                         |                                                             X            |      1     |
      Seminiferous Tubule, Atrophy         |                                                             1            |      1  1.0|
      Seminiferous Tubule, Mineralization  |                                                             1            |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  31                                                               
NTP Experiment-Test: 05030-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             PROBENECID                                        Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 15:49:50  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 5| 4|            |
                             DAY ON TEST   | 3| 3| 3| 3| 8| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 7| 1|            |
                                           | 2| 2| 3| 3| 2| 2| 2| 2| 2| 4| 2| 2| 2| 2| 2| 3| 3| 2| 3| 2| 3| 3| 3| 6| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +|  44        |
      Axillary, Infiltration Cellular,     |                                                                          |            |
           Plasma Cell                     |                                                                      3   |      1  3.0|
      Axillary, Infiltration Cellular,     |                                                                          |            |
           Lymphocyte                      |                                                                          |      1  2.0|
      Inguinal, Infiltration Cellular,     |                                                                          |            |
           Lymphocyte                      |                                                                          |      1  2.0|
      Lumbar, Infiltration Cellular,       |                                                                          |            |
          Plasma Cell                      |                                                                      2  2|      2  2.0|
      Lumbar, Infiltration Cellular,       |                                                                          |            |
          Lymphocyte                       |                                                                          |      1  2.0|
      Mediastinal, Infiltration Cellular,  |                                                                          |            |
           Histiocyte                      |                                                                          |      1  2.0|
      Renal, Infiltration Cellular, Plasma |                                                                          |            |
          Cell                             |                                                                         2|      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +|  44        |
      Angiectasis                          |             2  2        2  2     1  2        2  2     2     3            |     20  2.1|
      Hematopoietic Cell Proliferation     |                         1                       1           2            |      4  1.5|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|  49        |
      Fibrosis                             |                                                                          |      1  3.0|
      Hematopoietic Cell Proliferation     |    1  2                    2  1           1        2        2  2     3  2|     19  1.7|
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
      Lymphoid Follicle, Hyperplasia       |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  M  +  +|  47        |
      Atrophy                              |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  M  M  +  M  M  M  M  M  +  M  M  M  M  M  M  M  +  M  +  M  M|   4        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  A  +  +  +  +  +|  47        |
      Hyperplasia, Basal Cell              |                                                                          |      1  1.0|
      Necrosis                             |                                                                          |      1  2.0|
      Inguinal, Fungus                     |                                                                          |      1  3.0|
      Inguinal, Inflammation, Chronic      |                                                                          |            |
          Active                           |                                                                          |      1  3.0|
      Inguinal, Necrosis                   |                                                                          |      1  2.0|
      Prepuce, Inflammation, Chronic Active|                                                                2         |      2  2.0|
      Prepuce, Necrosis                    |                                                                2         |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  32                                                               
NTP Experiment-Test: 05030-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             PROBENECID                                        Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 15:49:50  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 5| 4|            |
                             DAY ON TEST   | 3| 3| 3| 3| 8| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 7| 1|            |
                                           | 2| 2| 3| 3| 2| 2| 2| 2| 2| 4| 2| 2| 2| 2| 2| 3| 3| 2| 3| 2| 3| 3| 3| 6| 0|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|  49        |
      Joint, Hyperostosis                  |                                                                          |      1  2.0|
      Tarsal, Hyperostosis                 | 3  3  4     3  3  3     3  2  3     3  3     3  3           4     3  3  3|     35  2.8|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  49        |
      Hemorrhage                           | 2                                            1                    3      |      6  1.5|
      Infiltration Cellular, Histiocyte    |                                                       2                  |      2  2.5|
      Inflammation, Acute                  |                                                                         2|      2  2.0|
      Alveolar Epithelium, Hyperplasia     |                                              2                           |      3  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  M  +  +  +  +  +  +  M  +  M  +  +  M  +  M  +  +  +|  40        |
      Edema                                |                                                                   2      |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  49        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                       +                  |   3        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                  +                    +                  |   4        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  49        |
      Bacterium                            |                                                                         1|      1  1.0|
      Cortex, Mineralization               |          1                       1           1     1  1        1         |     16  1.2|
      Papilla, Mineralization              |                1                                                         |      2  1.0|
      Papilla, Necrosis                    |                                                                          |      1  1.0|
      Renal Tubule, Regeneration           |                            2                                             |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  48        |
      Calculus Micro Observation Only      |                                     X                                    |      1     |
      Mineralization                       |                                                                          |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  33                                                               
NTP Experiment-Test: 05030-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             PROBENECID                                        Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 15:49:50  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 6| 4| 2| 1| 0| 7| 7| 6| 5| 0| 7| 7| 4| 3| 7| 7| 7| 4| 3|             
                             DAY ON TEST   | 3| 3| 3| 3| 2| 3| 3| 3| 0| 4| 0| 3| 3| 8| 6| 0| 3| 0| 6| 9| 3| 3| 3| 2| 0|             
                                           | 1| 1| 1| 1| 5| 1| 5| 1| 8| 3| 3| 1| 1| 3| 1| 3| 1| 7| 3| 0| 1| 1| 1| 6| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    .1 G/KG                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     LM                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  A  +  +  +  A  M  A  +  +  +  +  A  +  +  +  +  +  +  +  A  M|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Anus, Inflammation, Chronic Active   |                                                                          |             
      Anus, Necrosis                       |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoid Nodule, Hyperplasia         |                                  2                                       |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  M  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  A  +  A  +  +  +  +  M  +  +  +  +  +  +  +  A  +|             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  A  +  +  +  A  +  M  +  +  +  +  +  +  +  +  +  +  +  +  A  +|             
      Lymphoid Nodule, Hyperplasia         |                                              2                           |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  A  +  +  +  A  M  A  +  +  +  +  M  +  +  +  +  +  +  +  A  +|             
      Lymphoid Nodule, Hyperplasia         |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Fatty Change, Focal                  | 1                                                                        |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Necrosis, Coagulative                |                                                                         1|             
      Necrosis                             |             2                             2                              |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                 +                        |             
      Fat, Necrosis                        |                                                 2                        |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Hypertrophy                  |                                                                1         |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                            2                                             |             
      Hyperkeratosis                       |                                           2     2                        |             
      Inflammation, Acute                  |                                                                         1|             
      Necrosis                             |                            1                                             |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Necrosis                             |                                                                          |             
      Pigmentation                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                               1                    1                     |             
      Inflammation, Chronic Active         |                                                       2                  |             
      Thrombosis                           |             2                                                            |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  34                                                               
NTP Experiment-Test: 05030-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             PROBENECID                                        Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 15:49:50  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 6| 4| 2| 1| 0| 7| 7| 6| 5| 0| 7| 7| 4| 3| 7| 7| 7| 4| 3|             
                             DAY ON TEST   | 3| 3| 3| 3| 2| 3| 3| 3| 0| 4| 0| 3| 3| 8| 6| 0| 3| 0| 6| 9| 3| 3| 3| 2| 0|             
                                           | 1| 1| 1| 1| 5| 1| 5| 1| 8| 3| 3| 1| 1| 3| 1| 3| 1| 7| 3| 0| 1| 1| 1| 6| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    .1 G/KG                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     LM                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Capsule, Hyperplasia, Focal          |          3                                                               |             
      Capsule, Hyperplasia                 |                2                    2  2           2        2  1  1      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                                                                          |             
      Hemorrhage                           |                               2                                          |             
      Hyperplasia                          |                2                    2  2           2        2  1  1      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | M  +  +  +  M  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                     1  1                    2  2  3      |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  M  M  M  M  +  M  +  +  M  +  M  +  +  +  M  M  +  +  +  +  M  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M|             
      Pars Distalis, Cyst                  |                                           X                              |             
      Pars Distalis, Hyperplasia           |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |          +                                                               |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         |    +  +                    +     +                    +        +         |             
      Dilatation                           |                                                       3                  |             
      Inflammation, Chronic                |       3                                                                  |             
      Inflammation, Chronic Active         |    3                                                                     |             
      Necrosis                             |       2                          2                             4         |             
                                            __________________________________________________________________________|             
   Prostate                                | M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Inflammation, Acute                  |                         3                             3                  |             
      Inflammation, Chronic Active         |                                        3           3                     |             
      Necrosis                             |                                                                          |             
      Epithelium, Hyperplasia              |                                        2           3                     |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                    3                     |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Seminiferous Tubule, Atrophy         |                                        2                                 |             
      Seminiferous Tubule, Mineralization  |                                        2  2                              |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   | +        +  +  +                    +                       +            |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Axillary, Infiltration Cellular,     |                                                                          |             
           Plasma Cell                     |                                  3                    2                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  35                                                               
NTP Experiment-Test: 05030-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             PROBENECID                                        Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 15:49:50  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 6| 4| 2| 1| 0| 7| 7| 6| 5| 0| 7| 7| 4| 3| 7| 7| 7| 4| 3|             
                             DAY ON TEST   | 3| 3| 3| 3| 2| 3| 3| 3| 0| 4| 0| 3| 3| 8| 6| 0| 3| 0| 6| 9| 3| 3| 3| 2| 0|             
                                           | 1| 1| 1| 1| 5| 1| 5| 1| 8| 3| 3| 1| 1| 3| 1| 3| 1| 7| 3| 0| 1| 1| 1| 6| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    .1 G/KG                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     LM                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Lumbar, Hematopoietic Cell           |                                                                          |             
          Proliferation                    |                                                                         2|             
      Lumbar, Hyperplasia, Plasma Cell     |                                                                          |             
      Lumbar, Infiltration Cellular,       |                                                                          |             
          Plasma Cell                      |                      3           3                    2  2               |             
      Lumbar, Infiltration Cellular,       |                                                                          |             
          Histiocyte                       |                                                                          |             
      Pancreatic, Hematopoietic Cell       |                                                                          |             
          Proliferation                    |                                                                          |             
      Renal, Hematopoietic Cell            |                                                                          |             
          Proliferation                    |                                                                          |             
      Renal, Infiltration Cellular, Plasma |                                                                          |             
          Cell                             |                      3                                2                  |             
      Renal, Infiltration Cellular,        |                                                                          |             
          Histiocyte                       |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Angiectasis                          | 2  2  1     2  1  2                 2  3  2        4  2  2  2  2         |             
      Hematopoietic Cell Proliferation     |                   2                    2           3        2            |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Depletion Lymphoid                   |                            2                       2                     |             
      Hematopoietic Cell Proliferation     |                2     2     3           2  3     2  3           3        3|             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  M  M  M  +  +  +  M  A  +  +  +  M  +  +  +  +  +  +  +  +  M  M|             
      Atrophy                              |                                                                          |             
      Depletion Lymphoid                   |                         3                          4                     |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  +  M  M  M  +  M  M  +  M  M  M  M  M  M  +  M  M  +|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |             2                                                            |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Necrosis                             |                                                                   2      |             
      Prepuce, Acanthosis                  |                                                                          |             
      Prepuce, Hemorrhage                  |                                                                      3   |             
      Prepuce, Inflammation, Chronic Active|                                                    2                     |             
      Prepuce, Necrosis                    |                            3                                             |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Tarsal, Hyperostosis                 | 3  3  3     3  3                 3  2     3     3  3  2  3  3  3  3     3|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  36                                                               
NTP Experiment-Test: 05030-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             PROBENECID                                        Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 15:49:50  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 6| 4| 2| 1| 0| 7| 7| 6| 5| 0| 7| 7| 4| 3| 7| 7| 7| 4| 3|             
                             DAY ON TEST   | 3| 3| 3| 3| 2| 3| 3| 3| 0| 4| 0| 3| 3| 8| 6| 0| 3| 0| 6| 9| 3| 3| 3| 2| 0|             
                                           | 1| 1| 1| 1| 5| 1| 5| 1| 8| 3| 3| 1| 1| 3| 1| 3| 1| 7| 3| 0| 1| 1| 1| 6| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    .1 G/KG                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     LM                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                         4     3                                          |             
      Hemorrhage                           |                            2                 3                           |             
      Infiltration Cellular, Histiocyte    |                                                                          |             
      Inflammation, Acute                  |                                              3                           |             
      Alveolar Epithelium, Hyperplasia     |                   1                                                      |             
                                            __________________________________________________________________________|             
   Nose                                    | M  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                    3                     |             
      Casts Protein                        |                                           2                              |             
      Congestion                           |                                              2                           |             
      Hydronephrosis                       |                                                    3                     |             
      Inflammation, Acute                  |                         1                             2              2   |             
      Inflammation, Chronic Active         |                                                    3                     |             
      Cortex, Mineralization               |          1                                         2                     |             
      Papilla, Necrosis                    |                                                    4                     |             
      Renal Tubule, Casts Protein          |             2                                                            |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calculus Micro Observation Only      |                                                                          |             
      Inflammation, Acute                  |                                                       2                  |             
      Inflammation, Chronic Active         |                                                    3                    2|             
      Necrosis                             |                         3                                                |             
      Transitional Epithelium, Hyperplasia |                                                    4                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  37                                                               
NTP Experiment-Test: 05030-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             PROBENECID                                        Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 15:49:50  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 7| 7| 6| 4| 2| 7| 7| 7| 6| 4| 7| 6| 5| 5| 4| 7| 7| 7| 6| 4|            |
                             DAY ON TEST   | 3| 3| 3| 1| 4| 3| 3| 4| 4| 3| 3| 3| 3| 4| 1| 3| 5| 8| 1| 9| 3| 3| 3| 4| 5|            |
                                           | 1| 1| 1| 7| 5| 1| 1| 6| 3| 9| 1| 1| 1| 5| 6| 1| 9| 9| 5| 2| 2| 2| 1| 5| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
    .1 G/KG                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     LM                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  M  A  +  +  +  +  +|  40        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  49        |
      Anus, Inflammation, Chronic Active   |                            2                                             |      1  2.0|
      Anus, Necrosis                       |                            4                                             |      1  4.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  49        |
      Lymphoid Nodule, Hyperplasia         |                                              2                           |      2  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  45        |
      Necrosis                             |                                                 2                        |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  44        |
      Lymphoid Nodule, Hyperplasia         |       2                                                                  |      2  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  43        |
      Lymphoid Nodule, Hyperplasia         |       2                                                                  |      1  2.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                                                X         |      1     |
      Fatty Change, Focal                  |                                                                          |      1  1.0|
      Hematopoietic Cell Proliferation     |                            2                                             |      1  2.0|
      Necrosis, Coagulative                |                                                                          |      1  1.0|
      Necrosis                             |          3                             2                 2  2  2     3   |      8  2.3|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                +         |   2        |
      Fat, Necrosis                        |                                                                2         |      2  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acinus, Hypertrophy                  |                            1                                             |      2  1.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acanthosis                           |                   2  2                                                   |      3  2.0|
      Hyperkeratosis                       |                   2  2                                               2   |      5  2.0|
      Inflammation, Acute                  |                                                                          |      1  1.0|
      Necrosis                             |                      2                                   2               |      3  1.7|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                    1                     |      1  1.0|
      Necrosis                             |             2           1                                                |      2  1.5|
      Pigmentation                         |             2                                                            |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  38                                                               
NTP Experiment-Test: 05030-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             PROBENECID                                        Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 15:49:50  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 7| 7| 6| 4| 2| 7| 7| 7| 6| 4| 7| 6| 5| 5| 4| 7| 7| 7| 6| 4|            |
                             DAY ON TEST   | 3| 3| 3| 1| 4| 3| 3| 4| 4| 3| 3| 3| 3| 4| 1| 3| 5| 8| 1| 9| 3| 3| 3| 4| 5|            |
                                           | 1| 1| 1| 7| 5| 1| 1| 6| 3| 9| 1| 1| 1| 5| 6| 1| 9| 9| 5| 2| 2| 2| 1| 5| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
    .1 G/KG                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     LM                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Acute                  |                                                                          |      2  1.0|
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Thrombosis                           |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Capsule, Hyperplasia, Focal          |                4                                                         |      2  3.5|
      Capsule, Hyperplasia                 | 2  2  2  2  2        2  2     2  2  2     2  2  2  2        1            |     22  1.9|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accessory Adrenal Cortical Nodule    |                         X                                                |      1     |
      Hemorrhage                           |                                                                          |      1  2.0|
      Hyperplasia                          | 2  2  2  2  2  2     2  2     2  2  2     2  2  2  2        1            |     23  1.9|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|  44        |
      Hyperplasia                          | 2        2                                1        2  1                  |     10  1.7|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  M  M  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +|  35        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  M  +  +  +  +  +  +|  44        |
      Pars Distalis, Cyst                  |                                                                          |      1     |
      Pars Distalis, Hyperplasia           |                                  1                                       |      1  1.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |    +     +  +                 +     +           +     +  A     +        +|  15        |
      Dilatation                           |                                                       2                 3|      3  2.7|
      Inflammation, Chronic                |                                                                          |      1  3.0|
      Inflammation, Chronic Active         |    2     2                                                              2|      4  2.3|
      Necrosis                             |                                                                3         |      4  2.8|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Inflammation, Acute                  |                                                                          |      2  3.0|
      Inflammation, Chronic Active         |                                                                          |      2  3.0|
      Necrosis                             |                                                                         4|      1  4.0|
      Epithelium, Hyperplasia              |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  39                                                               
NTP Experiment-Test: 05030-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             PROBENECID                                        Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 15:49:50  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 7| 7| 6| 4| 2| 7| 7| 7| 6| 4| 7| 6| 5| 5| 4| 7| 7| 7| 6| 4|            |
                             DAY ON TEST   | 3| 3| 3| 1| 4| 3| 3| 4| 4| 3| 3| 3| 3| 4| 1| 3| 5| 8| 1| 9| 3| 3| 3| 4| 5|            |
                                           | 1| 1| 1| 7| 5| 1| 1| 6| 3| 9| 1| 1| 1| 5| 6| 1| 9| 9| 5| 2| 2| 2| 1| 5| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
    .1 G/KG                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     LM                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Seminiferous Tubule, Atrophy         |                            3                                             |      2  2.5|
      Seminiferous Tubule, Mineralization  |                                                                          |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |    +  +        +              +  +  +        +                    +      |  14        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  M  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
      Axillary, Infiltration Cellular,     |                                                                          |            |
           Plasma Cell                     |                                                                          |      2  2.5|
      Lumbar, Hematopoietic Cell           |                                                                          |            |
          Proliferation                    |                                           2                    2         |      3  2.0|
      Lumbar, Hyperplasia, Plasma Cell     |                                              2                           |      1  2.0|
      Lumbar, Infiltration Cellular,       |                                                                          |            |
          Plasma Cell                      |                         2              2  2                              |      7  2.3|
      Lumbar, Infiltration Cellular,       |                                                                          |            |
          Histiocyte                       |          2                                                               |      1  2.0|
      Pancreatic, Hematopoietic Cell       |                                                                          |            |
          Proliferation                    |                            2                                             |      1  2.0|
      Renal, Hematopoietic Cell            |                                                                          |            |
          Proliferation                    |                                                                2         |      1  2.0|
      Renal, Infiltration Cellular, Plasma |                                                                          |            |
          Cell                             |                                                                          |      2  2.5|
      Renal, Infiltration Cellular,        |                                                                          |            |
          Histiocyte                       |          2                                         2                     |      2  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  M  +  +  M  +  M  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +|  42        |
      Angiectasis                          | 2  2  3  2                    2                                          |     19  2.1|
      Hematopoietic Cell Proliferation     |                         3              3                                 |      6  2.5|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Depletion Lymphoid                   |                                                                          |      2  2.0|
      Hematopoietic Cell Proliferation     |    2     3     2  2     3  4  2     2  2  3           2  2     2  2  2  2|     25  2.4|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  A  +  +  +  M  M  +  +  +  +  +  +  M  M  M  +  +  +  +  +  +|  36        |
      Atrophy                              |                                        2                                 |      1  2.0|
      Depletion Lymphoid                   |                                                          3              2|      4  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  +  M  M  +  M  M  M  M  M  M  M  M  M  M  +  M  M  M  M  M  M|   8        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +|  49        |
      Hemorrhage                           |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  40                                                               
NTP Experiment-Test: 05030-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             PROBENECID                                        Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 15:49:50  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 7| 7| 6| 4| 2| 7| 7| 7| 6| 4| 7| 6| 5| 5| 4| 7| 7| 7| 6| 4|            |
                             DAY ON TEST   | 3| 3| 3| 1| 4| 3| 3| 4| 4| 3| 3| 3| 3| 4| 1| 3| 5| 8| 1| 9| 3| 3| 3| 4| 5|            |
                                           | 1| 1| 1| 7| 5| 1| 1| 6| 3| 9| 1| 1| 1| 5| 6| 1| 9| 9| 5| 2| 2| 2| 1| 5| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
    .1 G/KG                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     LM                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Acute                  |                                           2                              |      1  2.0|
      Inflammation, Chronic Active         |                                              2                           |      1  2.0|
      Necrosis                             |                                           3                              |      2  2.5|
      Prepuce, Acanthosis                  |             3                                                            |      1  3.0|
      Prepuce, Hemorrhage                  |                                                                          |      1  3.0|
      Prepuce, Inflammation, Chronic Active|                                                                          |      1  2.0|
      Prepuce, Necrosis                    |             2                                            3               |      3  2.7|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Tarsal, Hyperostosis                 | 2  3     4  2        4  3     3     4  2  4  3  4  3  3     3  3     3   |     33  3.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |    +                                                                     |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                                                                          |      2  3.5|
      Hemorrhage                           |                                                                          |      2  2.5|
      Infiltration Cellular, Histiocyte    |                                                             2            |      1  2.0|
      Inflammation, Acute                  |                         1                                                |      2  2.0|
      Alveolar Epithelium, Hyperplasia     |                                           1                              |      2  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |          +                                                               |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                                                          |      1  3.0|
      Casts Protein                        |                      2                          2                        |      3  2.0|
      Congestion                           |                                                                          |      1  2.0|
      Hydronephrosis                       |                                                                          |      1  3.0|
      Inflammation, Acute                  |                                        4                                 |      4  2.3|
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
      Cortex, Mineralization               |             2                                                           2|      4  1.8|
      Papilla, Necrosis                    |                                        3                                 |      2  3.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  41                                                               
NTP Experiment-Test: 05030-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             PROBENECID                                        Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 15:49:50  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 6| 7| 7| 6| 4| 2| 7| 7| 7| 6| 4| 7| 6| 5| 5| 4| 7| 7| 7| 6| 4|            |
                             DAY ON TEST   | 3| 3| 3| 1| 4| 3| 3| 4| 4| 3| 3| 3| 3| 4| 1| 3| 5| 8| 1| 9| 3| 3| 3| 4| 5|            |
                                           | 1| 1| 1| 7| 5| 1| 1| 6| 3| 9| 1| 1| 1| 5| 6| 1| 9| 9| 5| 2| 2| 2| 1| 5| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
    .1 G/KG                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     LM                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Renal Tubule, Casts Protein          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Calculus Micro Observation Only      |       X              X                                                   |      2     |
      Inflammation, Acute                  |                                        2                                 |      2  2.0|
      Inflammation, Chronic Active         |                                                                          |      2  2.5|
      Necrosis                             |                                        2                 2               |      3  2.3|
      Transitional Epithelium, Hyperplasia |                                        1                                 |      2  2.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  42                                                               
NTP Experiment-Test: 05030-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             PROBENECID                                        Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 15:49:50  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 4| 7| 7| 7| 6| 4| 7| 7| 7| 5| 3|             
                             DAY ON TEST   | 3| 3| 3| 3| 4| 3| 3| 3| 2| 6| 3| 3| 2| 2| 3| 3| 3| 3| 3| 0| 3| 1| 3| 1| 0|             
                                           | 1| 1| 1| 1| 6| 1| 1| 1| 2| 7| 1| 1| 5| 0| 8| 1| 1| 1| 4| 8| 1| 7| 1| 5| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    .4 G/KG                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     HM                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  A  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
      Inflammation, Acute                  |                                           4                              |             
      Necrosis                             |                                           3                              |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Clear Cell Focus                     |                X  X                                                      |             
      Cyst                                 |          X                                                               |             
      Fatty Change, Focal                  |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                   2      |             
      Hemorrhage                           |                                                                          |             
      Mineralization                       |                                     1                                    |             
      Necrosis                             |                         4  2        3     2                              |             
      Pigmentation                         |                         1                                                |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +|             
      Acanthosis, Focal                    |                                                                          |             
      Acanthosis                           |             1                                                            |             
      Hyperkeratosis                       |             2              1                                             |             
      Inflammation, Chronic Active         |                                                                          |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +|             
      Hyperplasia                          |                            1                                             |             
      Necrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |             2                                                            |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Capsule, Hyperplasia                 |    2  2  2  2  2  2  2     1  2  2  2     1  2  2  1        2  2  2  1   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  43                                                               
NTP Experiment-Test: 05030-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             PROBENECID                                        Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 15:49:50  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 4| 7| 7| 7| 6| 4| 7| 7| 7| 5| 3|             
                             DAY ON TEST   | 3| 3| 3| 3| 4| 3| 3| 3| 2| 6| 3| 3| 2| 2| 3| 3| 3| 3| 3| 0| 3| 1| 3| 1| 0|             
                                           | 1| 1| 1| 1| 6| 1| 1| 1| 2| 7| 1| 1| 5| 0| 8| 1| 1| 1| 4| 8| 1| 7| 1| 5| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    .4 G/KG                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     HM                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Accessory Adrenal Cortical Nodule    |          X                                                               |             
      Hyperplasia                          |    2  2  2  2     2  2     1     2  2     1  2  2  2        2     2  1   |             
      Hypertrophy                          | 1                                                                        |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                      1     1                 2     1              1      |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    2           1                                                         |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  M  +  +  +  +  M  M  +  +  M  +  +  +  +  M  +  M  M  M  M  +  +  +  M|             
      Cyst                                 |                                                                          |             
      Hyperplasia                          |                                     2                                    |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Hyperplasia           |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         |             +     +  +              +     +                       +     +|             
      Dilatation                           |                   3  3              3                                    |             
      Inflammation, Acute                  |                                                                   3     2|             
      Inflammation, Chronic Active         |                                                                          |             
      Necrosis                             |             2                       2                                    |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                                                          2              3|             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                                                          1               |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Interstitial Cell, Hyperplasia       |                                     2                                    |             
      Seminiferous Tubule, Atrophy         |                                                                          |             
      Seminiferous Tubule, Mineralization  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                             1            |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  M  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  M  +|             
      Axillary, Infiltration Cellular,     |                                                                          |             
           Plasma Cell                     |          3                                                               |             
      Lumbar, Infiltration Cellular,       |                                                                          |             
          Plasma Cell                      |                                                                         3|             
      Lumbar, Inflammation, Acute          |                                                          2               |             
      Mandibular, Necrosis                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  44                                                               
NTP Experiment-Test: 05030-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             PROBENECID                                        Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 15:49:50  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 4| 7| 7| 7| 6| 4| 7| 7| 7| 5| 3|             
                             DAY ON TEST   | 3| 3| 3| 3| 4| 3| 3| 3| 2| 6| 3| 3| 2| 2| 3| 3| 3| 3| 3| 0| 3| 1| 3| 1| 0|             
                                           | 1| 1| 1| 1| 6| 1| 1| 1| 2| 7| 1| 1| 5| 0| 8| 1| 1| 1| 4| 8| 1| 7| 1| 5| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    .4 G/KG                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     HM                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Mediastinal, Angiectasis             |                                                                          |             
      Mediastinal, Hematopoietic Cell      |                                                                          |             
          Proliferation                    |                                                                          |             
      Renal, Infiltration Cellular, Plasma |                                                                          |             
          Cell                             |                                           2                              |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  M  +  M  +  +  +  +  M  +  +  M  +  +  +  +  +  M  +  +  +  +  M  +|             
      Angiectasis                          |    2     2              3                    2     2           1  3      |             
      Hematopoietic Cell Proliferation     | 2        2                                   1                 3  2      |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 1                                                           1            |             
      Atrophy                              |                                                 3                        |             
      Depletion Lymphoid                   |                                                                          |             
      Hematopoietic Cell Proliferation     | 3  2  2  2  3     2        2     2  2     2                 3  3  2  2  3|             
      Necrosis                             |                                                          1               |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  M  +  +  +  M|             
      Atrophy                              |                                                                          |             
      Depletion Lymphoid                   |                            2                                             |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  +  M  M  M  M  M  +  M  M  M  M  M  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Prepuce, Hemorrhage                  |                                                                          |             
      Prepuce, Inflammation, Acute         |                                                                          |             
      Prepuce, Necrosis                    |                                                                         4|             
      Subcutaneous Tissue, Mineralization  |                                                                          |             
      Subcutaneous Tissue, Necrosis        |             2                                                            |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Tarsal, Hyperostosis                 | 3     3  4  3        3        2  3  2  4  2  3  4  3        4  3  3  2  3|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bacterium                            |                                                                          |             
      Congestion                           |                                                          2               |             
      Hemorrhage                           |                      2  1     2                                          |             
      Infiltration Cellular, Histiocyte    |             2                 3                                          |             
      Inflammation, Acute                  |             2                                                           3|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  45                                                               
NTP Experiment-Test: 05030-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             PROBENECID                                        Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 15:49:50  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 4| 7| 7| 7| 6| 4| 7| 7| 7| 5| 3|             
                             DAY ON TEST   | 3| 3| 3| 3| 4| 3| 3| 3| 2| 6| 3| 3| 2| 2| 3| 3| 3| 3| 3| 0| 3| 1| 3| 1| 0|             
                                           | 1| 1| 1| 1| 6| 1| 1| 1| 2| 7| 1| 1| 5| 0| 8| 1| 1| 1| 4| 8| 1| 7| 1| 5| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    .4 G/KG                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     HM                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Necrosis                             |                                                                          |             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Casts Protein                        |                            2        3                                    |             
      Congestion                           |                                                                          |             
      Glomerulosclerosis                   |                                     2                 3                  |             
      Hydronephrosis                       |                                     2                                    |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |                                     2                                    |             
      Inflammation, Chronic Active         |                                                                2         |             
      Cortex, Mineralization               |             1     1  1                                   1               |             
      Papilla, Mineralization              |             1                          1                                 |             
      Papilla, Necrosis                    |                                                                          |             
      Renal Tubule, Casts Protein          |                                                                          |             
      Renal Tubule, Regeneration           |    1           2                                               2         |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  M  +|             
      Calculus Micro Observation Only      |                                              X                           |             
      Inflammation, Acute                  |                                                          1               |             
      Necrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  46                                                               
NTP Experiment-Test: 05030-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             PROBENECID                                        Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 15:49:50  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 5| 3| 7| 6| 6| 5| 3| 7| 7| 6| 6| 6| 7| 7| 7| 5| 5| 0| 0| 7| 6| 7|            |
                             DAY ON TEST   | 3| 3| 3| 8| 5| 3| 8| 2| 0| 0| 3| 3| 4| 3| 1| 3| 3| 2| 6| 6| 2| 3| 3| 1| 3|            |
                                           | 1| 1| 1| 9| 5| 1| 6| 6| 9| 6| 1| 1| 0| 5| 1| 1| 1| 7| 8| 8| 0| 1| 1| 1| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      A     |
    .4 G/KG                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     HM                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  M  M  +  A  +  +  +  +  +  +  +  +  +  +  A  +  M  M  A  +  +  +|  40        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  A  +  A  +  +  A  +  +  +  +  +  +  +  A  +  M  +  A  +  +  +|  43        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  A  +  A  +  M  A  +  +  +  +  +  +  +  A  +  M  +  A  +  +  +|  40        |
      Inflammation, Acute                  |                                                                          |      1  4.0|
      Necrosis                             |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  A  +  +  +  A  A  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  A  +  +  +  A  A  +  +  +  +  +  +  +  A  +  M  +  A  +  +  +|  42        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  A  +  A  +  A  A  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|  43        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  M  A  +  A  +  A  A  +  +  +  +  M  +  +  A  +  M  +  A  M  +  +|  39        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |          2                                                               |      1  2.0|
      Clear Cell Focus                     |                                                                          |      2     |
      Cyst                                 |                                                                          |      1     |
      Fatty Change, Focal                  |             1                                                           2|      2  1.5|
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
      Hemorrhage                           |                                     2                                    |      1  2.0|
      Mineralization                       |                      2                                1                  |      3  1.3|
      Necrosis                             | 2        2  2        3     2     2  2     2           2  2               |     14  2.3|
      Pigmentation                         |                               1                                          |      2  1.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                   +                                                      |   1        |
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Acanthosis, Focal                    |                4                                                         |      1  4.0|
      Acanthosis                           | 3                 3                 3        2  3  2                     |      7  2.4|
      Hyperkeratosis                       | 2              2  3                 2     2  2  3  2                     |     10  2.1|
      Inflammation, Chronic Active         |                2  2                                                      |      2  2.0|
      Necrosis                             |             2     2                          2  3                        |      4  2.3|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  A  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  45        |
      Hyperplasia                          |                                                                          |      1  1.0|
      Necrosis                             |                                                             1            |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mineralization                       |             1                                                            |      2  1.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  47                                                               
NTP Experiment-Test: 05030-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             PROBENECID                                        Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 15:49:50  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 5| 3| 7| 6| 6| 5| 3| 7| 7| 6| 6| 6| 7| 7| 7| 5| 5| 0| 0| 7| 6| 7|            |
                             DAY ON TEST   | 3| 3| 3| 8| 5| 3| 8| 2| 0| 0| 3| 3| 4| 3| 1| 3| 3| 2| 6| 6| 2| 3| 3| 1| 3|            |
                                           | 1| 1| 1| 9| 5| 1| 6| 6| 9| 6| 1| 1| 0| 5| 1| 1| 1| 7| 8| 8| 0| 1| 1| 1| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      A     |
    .4 G/KG                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     HM                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Capsule, Hyperplasia                 | 2              2        2     2  2  2  2  2  2  2        2               |     30  1.9|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Accessory Adrenal Cortical Nodule    |                                                                          |      1     |
      Hyperplasia                          | 2              2     2  2     2     2  2  2  2  2        2              1|     28  1.9|
      Hypertrophy                          |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  M  +  +  +  +  M  +|  46        |
      Hyperplasia                          |          1                                                               |      6  1.2|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  M  M  M  +  +  M  M  +  +  M  M  +  M  +  +  +  M  +  M  M  +|  28        |
      Cyst                                 |                                                                         X|      1     |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  M  +  +  +  M  M  +  +  +  +  +  +  M  +  +  +  +  +|  44        |
      Pars Distalis, Hyperplasia           | 2                                                                        |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Cyst                                 |                                                                         X|      1     |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |    +  +     +  +        +        +        +  +  +     +  +  +  +  +      |  21        |
      Dilatation                           |       3                 2        3              3                 3      |      8  2.9|
      Inflammation, Acute                  |                                                                          |      2  2.5|
      Inflammation, Chronic Active         |    3  2                                         2     2  2               |      5  2.2|
      Necrosis                             |                3                                      2                  |      4  2.3|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Acute                  |                         2                                      2         |      4  2.3|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Acute                  |                         3                                                |      2  2.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Interstitial Cell, Hyperplasia       |                                                                          |      1  2.0|
      Seminiferous Tubule, Atrophy         |                   2                                   2                  |      2  2.0|
      Seminiferous Tubule, Mineralization  |                                              1        1                  |      2  1.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  48                                                               
NTP Experiment-Test: 05030-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             PROBENECID                                        Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 15:49:50  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 5| 3| 7| 6| 6| 5| 3| 7| 7| 6| 6| 6| 7| 7| 7| 5| 5| 0| 0| 7| 6| 7|            |
                             DAY ON TEST   | 3| 3| 3| 8| 5| 3| 8| 2| 0| 0| 3| 3| 4| 3| 1| 3| 3| 2| 6| 6| 2| 3| 3| 1| 3|            |
                                           | 1| 1| 1| 9| 5| 1| 6| 6| 9| 6| 1| 1| 0| 5| 1| 1| 1| 7| 8| 8| 0| 1| 1| 1| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      A     |
    .4 G/KG                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     HM                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | M  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  42        |
      Axillary, Infiltration Cellular,     |                                                                          |            |
           Plasma Cell                     |                                                                          |      1  3.0|
      Lumbar, Infiltration Cellular,       |                                                                          |            |
          Plasma Cell                      |                                        2                                 |      2  2.5|
      Lumbar, Inflammation, Acute          |                                                                          |      1  2.0|
      Mandibular, Necrosis                 |                   2                                                      |      1  2.0|
      Mediastinal, Angiectasis             |          2                                                               |      1  2.0|
      Mediastinal, Hematopoietic Cell      |                                                                          |            |
          Proliferation                    |          3                                                               |      1  3.0|
      Renal, Infiltration Cellular, Plasma |                                                                          |            |
          Cell                             |                                  2                    1                  |      3  1.7|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | M  +  +  M  +  +  +  M  M  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|  38        |
      Angiectasis                          |                2              2              2  1  3                 3  3|     14  2.2|
      Hematopoietic Cell Proliferation     |       2        2                                2                    2   |      9  2.0|
      Necrosis                             |                   2                                                      |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  A  +  +  +|  48        |
      Angiectasis                          |                                                                          |      2  1.0|
      Atrophy                              |                                                                          |      1  3.0|
      Depletion Lymphoid                   |                                                             2            |      1  2.0|
      Hematopoietic Cell Proliferation     | 2     2  2     2  2  2  2        3     2  3     2     3     2        2   |     29  2.3|
      Necrosis                             |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  M  +  M  M  M  M  +  +  +  M  +  +  +  +  +  +  M  +  M  +  M|  36        |
      Atrophy                              |                                                                3         |      1  3.0|
      Depletion Lymphoid                   |                                           2                              |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  +  M  M  M  M  M  M  +  M  M  M  M  M  M  M  M  M  M  M  M  M  M|   4        |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Prepuce, Hemorrhage                  |                                                          2               |      1  2.0|
      Prepuce, Inflammation, Acute         |                                                                1         |      1  1.0|
      Prepuce, Necrosis                    |                                                             3            |      2  3.5|
      Subcutaneous Tissue, Mineralization  |                                                    1                     |      1  1.0|
      Subcutaneous Tissue, Necrosis        |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  49                                                               
NTP Experiment-Test: 05030-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             PROBENECID                                        Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 15:49:50  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 5| 3| 7| 6| 6| 5| 3| 7| 7| 6| 6| 6| 7| 7| 7| 5| 5| 0| 0| 7| 6| 7|            |
                             DAY ON TEST   | 3| 3| 3| 8| 5| 3| 8| 2| 0| 0| 3| 3| 4| 3| 1| 3| 3| 2| 6| 6| 2| 3| 3| 1| 3|            |
                                           | 1| 1| 1| 9| 5| 1| 6| 6| 9| 6| 1| 1| 0| 5| 1| 1| 1| 7| 8| 8| 0| 1| 1| 1| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      A     |
    .4 G/KG                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     HM                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Tarsal, Hyperostosis                 | 2  3  4  2  2  4  2  3        4  3        2  3  3  3  3  3        2  3   |     36  2.9|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                           +                              |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                        +              +                  |   2        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Bacterium                            |                                                                1         |      1  1.0|
      Congestion                           |                         2                                                |      2  2.0|
      Hemorrhage                           |                                                          1               |      4  1.5|
      Infiltration Cellular, Histiocyte    |                                                                          |      2  2.5|
      Inflammation, Acute                  |                                                                          |      2  2.5|
      Necrosis                             |                                           2                              |      1  2.0|
      Pigmentation                         |             1                                                            |      1  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | M  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +|  43        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Casts Protein                        |                                                       1              3   |      4  2.3|
      Congestion                           |                                                       2                  |      1  2.0|
      Glomerulosclerosis                   |          2                                                           2   |      4  2.3|
      Hydronephrosis                       |                                                                          |      1  2.0|
      Inflammation, Acute                  |          3                                                               |      1  3.0|
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Cortex, Mineralization               |    1                    2              1        1                       1|      9  1.1|
      Papilla, Mineralization              |                         2                                                |      3  1.3|
      Papilla, Necrosis                    |          3                                                               |      1  3.0|
      Renal Tubule, Casts Protein          |          2                                                               |      1  2.0|
      Renal Tubule, Regeneration           |                                                       1                  |      4  1.5|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Calculus Micro Observation Only      |                                                                   X      |      2     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  50                                                               
NTP Experiment-Test: 05030-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             PROBENECID                                        Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 15:49:50  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 5| 3| 7| 6| 6| 5| 3| 7| 7| 6| 6| 6| 7| 7| 7| 5| 5| 0| 0| 7| 6| 7|            |
                             DAY ON TEST   | 3| 3| 3| 8| 5| 3| 8| 2| 0| 0| 3| 3| 4| 3| 1| 3| 3| 2| 6| 6| 2| 3| 3| 1| 3|            |
                                           | 1| 1| 1| 9| 5| 1| 6| 6| 9| 6| 1| 1| 0| 5| 1| 1| 1| 7| 8| 8| 0| 1| 1| 1| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      A     |
    .4 G/KG                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     HM                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Acute                  |                                                             2  3         |      3  2.0|
      Necrosis                             |          2                                                               |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  51                                                               
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                             ----------              END OF REPORT             ----------                                           
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