TR 395 Mouse Pathology Tables
NTP Experiment-Test: 05030-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROBENECID Date: 04/29/97
Route: GAVAGE Time: 15:49:50
Facility: TSI Mason Research
Chemical CAS #: 000057669
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
Page 1
NTP Experiment-Test: 05030-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROBENECID Date: 04/29/97
Route: GAVAGE Time: 15:49:50
_____________________________________________________________________________________________________________________
| 0| 7| 7| 7| 7| 7| 7| 7| 6| 6| 0| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5|
DAY ON TEST | 2| 3| 3| 2| 0| 3| 3| 3| 8| 1| 1| 3| 3| 4| 1| 3| 3| 3| 0| 6| 3| 3| 3| 3| 9|
| 9| 6| 6| 2| 9| 2| 2| 2| 7| 2| 3| 2| 2| 8| 2| 5| 2| 6| 4| 0| 5| 5| 2| 2| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + M M + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + M + + + + + + + + A + + + + A|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + A + + + + + + + + A + + + + A|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + A + + + + + + + + + + + + + +|
Necrosis | 2 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + A + + + + + + + + + + + + + A|
Necrosis | 2 |
Lymphoid Nodule, Hemorrhage | 2 |
__________________________________________________________________________|
Liver | + + + + + + + + + A + + + + + + + + + + + + + +|
Basophilic Focus | 3 |
Clear Cell Focus | 3 |
Fatty Change, Diffuse | |
Fatty Change, Focal | |
Hematopoietic Cell Proliferation | 2 |
Mineralization | 2 |
Necrosis | 1 1 1 2 2 1 1 1 |
__________________________________________________________________________|
Mesentery | + + |
Inflammation, Acute | 3 |
Inflammation, Chronic Active | 4 |
Fat, Inflammation, Chronic Active | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + A + + + + + + + + + + + + + +|
Acinus, Hyperplasia | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + A + + + + + + + + + + + + + +|
Mineralization | |
__________________________________________________________________________|
Stomach | + + + + + + + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + A + + + + + + + + + + + + + +|
Acanthosis | 1 1 1 2 2 1 |
Hyperkeratosis | 2 3 2 2 3 3 2 2 |
Inflammation, Acute | |
Mineralization | 1 |
Necrosis | 2 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + A + + + + + + + + + + + + + +|
Dilatation | |
Hyperplasia | 2 3 2 |
Inflammation, Chronic Active | 2 |
Pigmentation | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 2
NTP Experiment-Test: 05030-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROBENECID Date: 04/29/97
Route: GAVAGE Time: 15:49:50
_____________________________________________________________________________________________________________________
| 0| 7| 7| 7| 7| 7| 7| 7| 6| 6| 0| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5|
DAY ON TEST | 2| 3| 3| 2| 0| 3| 3| 3| 8| 1| 1| 3| 3| 4| 1| 3| 3| 3| 0| 6| 3| 3| 3| 3| 9|
| 9| 6| 6| 2| 9| 2| 2| 2| 7| 2| 3| 2| 2| 8| 2| 5| 2| 6| 4| 0| 5| 5| 2| 2| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM - cont | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + A + + + + + + + + + + + + + +|
Cardiomyopathy | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + A + + + + + + + + + + + + + +|
Capsule, Hyperplasia | 2 2 1 2 2 2 2 2 2 2 2 3 2 2 2 2 2 |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + A + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | X |
Cyst | X |
Hematopoietic Cell Proliferation | 1 |
Hyperplasia | 2 2 1 2 2 2 2 2 2 2 3 2 2 2 2 2 |
Hypertrophy | 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + M + + + + + A + + M + + + + + + + + + + +|
Degeneration | 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + M M + + + M + M M + + + M + M + + + + + M +|
__________________________________________________________________________|
Pituitary Gland | + + M M + + + M + A + + + + + M + + + + + + + +|
Angiectasis | 2 |
Pars Distalis, Angiectasis | 1 |
Pars Distalis, Hyperplasia, Focal | |
Pars Distalis, Hyperplasia | 2 3 2 2 1 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + A + + + + + + + + + + + + + +|
Follicle, Cyst | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + A + + + + + + + + + M + + + +|
Abscess | 4 |
Cyst | X X |
Degeneration, Cystic | 2 3 2 3 3 3 3 |
Hemorrhage | |
Hyperplasia | |
Mineralization | |
Pigmentation | |
__________________________________________________________________________|
Uterus | + + + + + + + + + A + + + + + + + + + + + + + +|
Hemorrhage | |
Hyperplasia | |
Inflammation, Acute | |
Endometrium, Hyperplasia | 3 3 3 2 2 2 2 3 3 2 2 3 3 3 4 2 3 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 3
NTP Experiment-Test: 05030-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROBENECID Date: 04/29/97
Route: GAVAGE Time: 15:49:50
_____________________________________________________________________________________________________________________
| 0| 7| 7| 7| 7| 7| 7| 7| 6| 6| 0| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5|
DAY ON TEST | 2| 3| 3| 2| 0| 3| 3| 3| 8| 1| 1| 3| 3| 4| 1| 3| 3| 3| 0| 6| 3| 3| 3| 3| 9|
| 9| 6| 6| 2| 9| 2| 2| 2| 7| 2| 3| 2| 2| 8| 2| 5| 2| 6| 4| 0| 5| 5| 2| 2| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + A + + + + + + + + + + + + + +|
Myelofibrosis | 3 3 3 2 2 3 2 |
__________________________________________________________________________|
Lymph Node | + + + + + M + + + M + + + + + + + + + + + + + +|
Lumbar, Infiltration Cellular, | |
Plasma Cell | 2 |
Mandibular, Infiltration Cellular, | |
Plasma Cell | 3 |
Renal, Infiltration Cellular, Plasma | |
Cell | 3 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + M + + + M + + M + + + + + + + + + + +|
Angiectasis | 4 1 3 |
Hematopoietic Cell Proliferation | 2 2 |
Infiltration Cellular, Plasma Cell | 3 |
__________________________________________________________________________|
Spleen | + + + + + + + + + M + + + + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 2 2 2 2 2 3 3 2 2 1 2 |
Necrosis | 2 |
Lymphoid Follicle, Hyperplasia | 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + A M + + + + + + M + + + + + +|
Angiectasis | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M + + M M M M M + M M + + + M + + + + M M M M +|
__________________________________________________________________________|
Skin | + + + + + + + + + A M + + + + + + + + + + + M +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + A + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + M + + + + + A + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Hemorrhage | 1 1 |
Infiltration Cellular, Histiocyte | 2 |
__________________________________________________________________________|
Nose | + + + M M + + + + A + + + + + + + + + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + A + + + + + + + + + + + + + +|
Cyst | X |
_____________________________________________________________________________________________________________________|
Page 4
NTP Experiment-Test: 05030-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROBENECID Date: 04/29/97
Route: GAVAGE Time: 15:49:50
_____________________________________________________________________________________________________________________
| 0| 7| 7| 7| 7| 7| 7| 7| 6| 6| 0| 7| 7| 6| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5|
DAY ON TEST | 2| 3| 3| 2| 0| 3| 3| 3| 8| 1| 1| 3| 3| 4| 1| 3| 3| 3| 0| 6| 3| 3| 3| 3| 9|
| 9| 6| 6| 2| 9| 2| 2| 2| 7| 2| 3| 2| 2| 8| 2| 5| 2| 6| 4| 0| 5| 5| 2| 2| 6|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
Degeneration | |
Hydronephrosis | 2 |
Cortex, Mineralization | |
Papilla, Mineralization | 1 |
Renal Tubule, Pigmentation | |
Renal Tubule, Regeneration | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + A + + + + + + + + + M + + + +|
Edema | 1 |
Infiltration Cellular, | |
Polymorphonuclear | 2 |
_____________________________________________________________________________________________________________________|
Page 5
NTP Experiment-Test: 05030-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROBENECID Date: 04/29/97
Route: GAVAGE Time: 15:49:50
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| |
DAY ON TEST | 3| 2| 0| 8| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| |
| 5| 1| 9| 7| 3| 5| 5| 5| 5| 5| 5| 5| 5| 6| 5| 5| 5| 5| 5| 5| 5| 5| 6| 0| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + A + + + + + + + + A +| 44 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + M + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + M + M + + + + + + + + + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + A + + + + + + + + + +| 47 |
Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + A + + + + + + + + + +| 46 |
Necrosis | | 1 2.0|
Lymphoid Nodule, Hemorrhage | | 1 2.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Basophilic Focus | X | 2 3.0|
Clear Cell Focus | | 1 3.0|
Fatty Change, Diffuse | 2 | 1 2.0|
Fatty Change, Focal | 1 2 | 2 1.5|
Hematopoietic Cell Proliferation | | 1 2.0|
Mineralization | 1 | 2 1.5|
Necrosis | 2 1 | 10 1.3|
__________________________________________________________________________|____________|
Mesentery | +| 3 |
Inflammation, Acute | | 1 3.0|
Inflammation, Chronic Active | | 1 4.0|
Fat, Inflammation, Chronic Active | 3| 1 3.0|
Fat, Necrosis | 2| 1 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Acinus, Hyperplasia | 1 | 2 1.5|
__________________________________________________________________________|____________|
Salivary Glands | + M + + + + + + M + + + + + M + + + + + + + + + +| 45 |
Mineralization | 1 | 1 1.0|
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + A + + + + + + + + + +| 47 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + A + + + + + + + + + +| 47 |
Acanthosis | 2 2 3 2 2 | 11 1.7|
Hyperkeratosis | 3 2 2 2 3 3 | 14 2.4|
Inflammation, Acute | 2 2 | 2 2.0|
Mineralization | | 1 1.0|
Necrosis | 1 | 2 1.5|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + M A + + + + + + + + + +| 46 |
Dilatation | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 6
NTP Experiment-Test: 05030-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROBENECID Date: 04/29/97
Route: GAVAGE Time: 15:49:50
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| |
DAY ON TEST | 3| 2| 0| 8| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| |
| 5| 1| 9| 7| 3| 5| 5| 5| 5| 5| 5| 5| 5| 6| 5| 5| 5| 5| 5| 5| 5| 5| 6| 0| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
Hyperplasia | 2 2 | 5 2.2|
Inflammation, Chronic Active | | 1 2.0|
Pigmentation | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Cardiomyopathy | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Capsule, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2 2 3 2 2 2 3 2 2 2 | 38 2.1|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Accessory Adrenal Cortical Nodule | | 1 |
Cyst | | 1 |
Hematopoietic Cell Proliferation | 2| 2 1.5|
Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2 2 3 2 2 2 3 2 2 2 | 37 2.1|
Hypertrophy | | 1 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + M + +| 44 |
Degeneration | | 1 1.0|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Parathyroid Gland | M + M + M M + M + + M M M + + + + + M + + M + M M| 29 |
__________________________________________________________________________|____________|
Pituitary Gland | + M M + M + + + + + + + + + + + + + + + + + + + +| 41 |
Angiectasis | | 1 2.0|
Pars Distalis, Angiectasis | 2 2 | 3 1.7|
Pars Distalis, Hyperplasia, Focal | 2 | 1 2.0|
Pars Distalis, Hyperplasia | 2 3 2 2 2 1 2 | 13 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Follicle, Cyst | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
Abscess | | 1 4.0|
Cyst | X X | 4 |
Degeneration, Cystic | 3 2 3 4 3 | 12 2.8|
Hemorrhage | 4 4 | 2 4.0|
Hyperplasia | 3 | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 7
NTP Experiment-Test: 05030-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROBENECID Date: 04/29/97
Route: GAVAGE Time: 15:49:50
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| |
DAY ON TEST | 3| 2| 0| 8| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| |
| 5| 1| 9| 7| 3| 5| 5| 5| 5| 5| 5| 5| 5| 6| 5| 5| 5| 5| 5| 5| 5| 5| 6| 0| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Mineralization | 1 2 | 2 1.5|
Pigmentation | 2 2 2 | 3 2.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hemorrhage | 2 | 1 2.0|
Hyperplasia | 2 | 1 2.0|
Inflammation, Acute | 1 | 1 1.0|
Endometrium, Hyperplasia | 2 2 2 3 2 3 2 2 2 2 3 2 2 2 3 3 2 2 | 36 2.4|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + + + + + + + + + + + + + + + + | 30 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Myelofibrosis | 2 2 2 3 3 2 | 13 2.5|
__________________________________________________________________________|____________|
Lymph Node | M + + M + + + + M + + + + + + + + + + + + + + + M| 43 |
Lumbar, Infiltration Cellular, | | |
Plasma Cell | | 1 2.0|
Mandibular, Infiltration Cellular, | | |
Plasma Cell | | 1 3.0|
Renal, Infiltration Cellular, Plasma | | |
Cell | | 1 3.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | M + + M + + + M M + + + + + + + + + + + + + + + M| 41 |
Angiectasis | 2 | 4 2.5|
Hematopoietic Cell Proliferation | 2 | 3 2.0|
Infiltration Cellular, Plasma Cell | | 1 3.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Hematopoietic Cell Proliferation | 3 2 2 2 2 2 2 2 2 2 2 3 4| 24 2.2|
Necrosis | | 1 2.0|
Lymphoid Follicle, Hyperplasia | 2 | 2 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + M + + + M + + + + + + M + + + M| 42 |
Angiectasis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + M + M M M M M M + M + M M + + M + M M M + +| 22 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +| 46 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 47 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 8
NTP Experiment-Test: 05030-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROBENECID Date: 04/29/97
Route: GAVAGE Time: 15:49:50
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 5| |
DAY ON TEST | 3| 2| 0| 8| 0| 3| 3| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| |
| 5| 1| 9| 7| 3| 5| 5| 5| 5| 5| 5| 5| 5| 6| 5| 5| 5| 5| 5| 5| 5| 5| 6| 0| 9| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
FEMALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Congestion | 2 | 1 2.0|
Hemorrhage | 1 1 | 4 1.0|
Infiltration Cellular, Histiocyte | 3 | 2 2.5|
__________________________________________________________________________|____________|
Nose | + + + M + + + + + + + + + + M + + + + + + M M M +| 41 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Cyst | | 1 |
Degeneration | 2 | 1 2.0|
Hydronephrosis | | 1 2.0|
Cortex, Mineralization | 2 | 1 2.0|
Papilla, Mineralization | | 1 1.0|
Renal Tubule, Pigmentation | 3 | 1 3.0|
Renal Tubule, Regeneration | 2 | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + M + + + + + + + + + + + + + + A +| 44 |
Edema | | 1 1.0|
Infiltration Cellular, | | |
Polymorphonuclear | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 9
NTP Experiment-Test: 05030-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROBENECID Date: 04/29/97
Route: GAVAGE Time: 15:49:50
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 3| 7| 7| 7| 4| 3|
DAY ON TEST | 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 0| 9| 3| 3| 3| 3| 3| 3| 3| 3| 8| 4|
| 1| 1| 1| 1| 7| 1| 1| 1| 1| 1| 1| 1| 1| 6| 5| 2| 2| 2| 1| 7| 2| 2| 1| 8| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
.1 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + M|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + M A + + + + A + + + + A|
__________________________________________________________________________|
Intestine Large | + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | M + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + +|
Lymphoid Nodule, Hyperplasia | |
__________________________________________________________________________|
Intestine Large, Rectum | + M + M +|
__________________________________________________________________________|
Intestine Small | + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + A +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + A +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | |
Fatty Change, Diffuse | |
Fatty Change, Focal | 1 1 2 1 1 |
Hematopoietic Cell Proliferation | 2 |
Necrosis, Coagulative | 2 |
Necrosis | 2 1 |
Bile Duct, Hyperplasia, Cystic | |
__________________________________________________________________________|
Mesentery | + |
Hemorrhage | |
Inflammation, Acute | 3 |
Fat, Inflammation, Chronic Active | |
Fat, Necrosis | |
__________________________________________________________________________|
Pancreas | + + + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 3 3 2 1 |
Hyperkeratosis | 3 3 2 |
Inflammation, Chronic Active | 1 |
Necrosis | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 2 2 1 2 1 1 1 |
Inflammation, Acute | 2 |
Inflammation, Chronic Active | 2 |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + M +|
Capsule, Hyperplasia | 2 |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + M +|
_____________________________________________________________________________________________________________________|
Page 10
NTP Experiment-Test: 05030-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROBENECID Date: 04/29/97
Route: GAVAGE Time: 15:49:50
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 3| 7| 7| 7| 4| 3|
DAY ON TEST | 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 0| 9| 3| 3| 3| 3| 3| 3| 3| 3| 8| 4|
| 1| 1| 1| 1| 7| 1| 1| 1| 1| 1| 1| 1| 1| 6| 5| 2| 2| 2| 1| 7| 2| 2| 1| 8| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
.1 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Hematopoietic Cell Proliferation | |
Hyperplasia | 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + M +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + + + + + + + + M M + + M + + + + M|
__________________________________________________________________________|
Pituitary Gland | + M + + + + + +|
Pars Distalis, Hyperplasia | 3 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + M + + + + +|
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Ovary | + + + + + + + + + M + + + + + + + + + + + + + + +|
Abscess | |
Cyst | X X X |
Degeneration, Cystic | 3 4 3 2 3 |
Hemorrhage | 2 |
Hyperplasia | 2 |
Mineralization | |
Pigmentation | |
Bilateral, Abscess | 4 |
__________________________________________________________________________|
Oviduct | |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + +|
Cyst | |
Inflammation, Acute | |
Necrosis | 2 |
Endometrium, Hyperplasia | 3 2 2 2 |
__________________________________________________________________________|
Vagina | + |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + + + + + + + + + + + |
__________________________________________________________________________|
Bone Marrow | + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + +|
Lumbar, Angiectasis | |
Lumbar, Hematopoietic Cell | |
Proliferation | 2 |
Lumbar, Infiltration Cellular, | |
Plasma Cell | 2 2 2 |
Lumbar, Infiltration Cellular, | |
Histiocyte | 3 |
Mediastinal, Infiltration Cellular, | |
Plasma Cell | |
_____________________________________________________________________________________________________________________|
Page 11
NTP Experiment-Test: 05030-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROBENECID Date: 04/29/97
Route: GAVAGE Time: 15:49:50
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 3| 7| 7| 7| 4| 3|
DAY ON TEST | 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 0| 9| 3| 3| 3| 3| 3| 3| 3| 3| 8| 4|
| 1| 1| 1| 1| 7| 1| 1| 1| 1| 1| 1| 1| 1| 6| 5| 2| 2| 2| 1| 7| 2| 2| 1| 8| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
.1 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Pancreatic, Hematopoietic Cell | |
Proliferation | |
Renal, Hematopoietic Cell | |
Proliferation | |
Renal, Hemorrhage | |
Renal, Infiltration Cellular, Plasma | |
Cell | 2 2 |
Renal, Infiltration Cellular, | |
Histiocyte | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + +|
Hematopoietic Cell Proliferation | 2 |
Hemorrhage | 2 |
Infiltration Cellular, Plasma Cell | 2 |
Infiltration Cellular, Histiocyte | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + +|
Hematopoietic Cell Proliferation | 3 3 2 2 3 |
Hemorrhage | |
Thrombosis | |
__________________________________________________________________________|
Thymus | + + + + + +|
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | + + + + + M|
__________________________________________________________________________|
Skin | + + + + + +|
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + +|
Hemorrhage | |
Infiltration Cellular, Histiocyte | |
Inflammation, Chronic Active | |
Pleura, Abscess | 4|
__________________________________________________________________________|
Nose | + M + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | |
__________________________________________________________________________|
Harderian Gland | |
Mineralization | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 12
NTP Experiment-Test: 05030-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROBENECID Date: 04/29/97
Route: GAVAGE Time: 15:49:50
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 5| 7| 7| 7| 7| 3| 7| 7| 7| 4| 3|
DAY ON TEST | 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 0| 9| 3| 3| 3| 3| 3| 3| 3| 3| 8| 4|
| 1| 1| 1| 1| 7| 1| 1| 1| 1| 1| 1| 1| 1| 6| 5| 2| 2| 2| 1| 7| 2| 2| 1| 8| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|
.1 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Kidney | + + + + + + + +|
Inflammation, Chronic Active | 1 |
Cortex, Mineralization | |
__________________________________________________________________________|
Urinary Bladder | + M + + +|
_____________________________________________________________________________________________________________________|
Page 13
NTP Experiment-Test: 05030-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROBENECID Date: 04/29/97
Route: GAVAGE Time: 15:49:50
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 5| 5| 0| 7| 7| 5| 5| 7| 7| 6| 6| 6| 7| 7| 7| 7| 6| 7| 7| 6| 6| 1| |
DAY ON TEST | 3| 3| 3| 7| 4| 2| 3| 3| 5| 3| 3| 3| 7| 4| 2| 3| 3| 3| 3| 8| 3| 3| 9| 4| 0| |
| 2| 2| 2| 0| 7| 9| 2| 2| 0| 6| 2| 2| 4| 4| 7| 2| 2| 2| 2| 6| 2| 2| 4| 6| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
.1 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + + + + M + + + A +| 41 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + +| 15 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + +| 14 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + +| 15 |
Lymphoid Nodule, Hyperplasia | 2| 1 2.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + A + M + + + M + +| 10 |
__________________________________________________________________________|____________|
Intestine Small | + A + + + + + + + + +| 16 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + A + + + + + + + A +| 14 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + A + + + + + + + + +| 16 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + A + + + + + + + A +| 14 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Congestion | 3 | 1 3.0|
Fatty Change, Diffuse | 2 | 1 2.0|
Fatty Change, Focal | 1 2 1 | 8 1.3|
Hematopoietic Cell Proliferation | 1 2 2 2 2 2 | 7 1.9|
Necrosis, Coagulative | | 1 2.0|
Necrosis | 2 1 | 4 1.5|
Bile Duct, Hyperplasia, Cystic | 2 | 1 2.0|
__________________________________________________________________________|____________|
Mesentery | + + + + | 5 |
Hemorrhage | 4 | 1 4.0|
Inflammation, Acute | 3 3 | 3 3.0|
Fat, Inflammation, Chronic Active | 2 | 1 2.0|
Fat, Necrosis | 3 | 1 3.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + +| 19 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + +| 15 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Acanthosis | 2 2 2 2 3 1 2 | 11 2.1|
Hyperkeratosis | 2 1 3 1 1 2 3 2 2 | 12 2.1|
Inflammation, Chronic Active | | 1 1.0|
Necrosis | 2 3 3 2 2 2 | 6 2.3|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + A + + + + + + + + + + + + + + + + + + +| 48 |
Hyperplasia | 1 2 2 2 1 | 14 1.5|
Inflammation, Acute | | 1 2.0|
Inflammation, Chronic Active | 2 | 2 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + +| 15 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 14
NTP Experiment-Test: 05030-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROBENECID Date: 04/29/97
Route: GAVAGE Time: 15:49:50
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 5| 5| 0| 7| 7| 5| 5| 7| 7| 6| 6| 6| 7| 7| 7| 7| 6| 7| 7| 6| 6| 1| |
DAY ON TEST | 3| 3| 3| 7| 4| 2| 3| 3| 5| 3| 3| 3| 7| 4| 2| 3| 3| 3| 3| 8| 3| 3| 9| 4| 0| |
| 2| 2| 2| 0| 7| 9| 2| 2| 0| 6| 2| 2| 4| 4| 7| 2| 2| 2| 2| 6| 2| 2| 4| 6| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
.1 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + +| 14 |
Capsule, Hyperplasia | 2 2 2 2 2 2| 7 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + +| 14 |
Hematopoietic Cell Proliferation | 2 | 1 2.0|
Hyperplasia | 2 2 2 2 2 2| 7 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + + +| 13 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + A + + + + + + + +| 15 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + + M + M + + M + + + M + + + + +| 29 |
__________________________________________________________________________|____________|
Pituitary Gland | M + M M + + + + +| 13 |
Pars Distalis, Hyperplasia | 2 | 2 2.5|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Follicular Cell, Hyperplasia | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | + | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Abscess | 3 4 4 | 3 3.7|
Cyst | X | 4 |
Degeneration, Cystic | 2 3 2 3 | 9 2.8|
Hemorrhage | | 1 2.0|
Hyperplasia | | 1 2.0|
Mineralization | 2 | 1 2.0|
Pigmentation | 2 | 1 2.0|
Bilateral, Abscess | 4 4 4 | 4 4.0|
__________________________________________________________________________|____________|
Oviduct | + | 1 |
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + +| 30 |
Cyst | X | 1 |
Inflammation, Acute | 2 3 | 2 2.5|
Necrosis | | 1 2.0|
Endometrium, Hyperplasia | 2 3 2 2 2 2 3 3 2 2 | 14 2.3|
__________________________________________________________________________|____________|
Vagina | | 1 |
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + + + + + + + + + + + + | 26 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + +| 14 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 15
NTP Experiment-Test: 05030-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROBENECID Date: 04/29/97
Route: GAVAGE Time: 15:49:50
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 5| 5| 0| 7| 7| 5| 5| 7| 7| 6| 6| 6| 7| 7| 7| 7| 6| 7| 7| 6| 6| 1| |
DAY ON TEST | 3| 3| 3| 7| 4| 2| 3| 3| 5| 3| 3| 3| 7| 4| 2| 3| 3| 3| 3| 8| 3| 3| 9| 4| 0| |
| 2| 2| 2| 0| 7| 9| 2| 2| 0| 6| 2| 2| 4| 4| 7| 2| 2| 2| 2| 6| 2| 2| 4| 6| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
.1 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + +| 26 |
Lumbar, Angiectasis | 2 | 1 2.0|
Lumbar, Hematopoietic Cell | | |
Proliferation | 2 2 | 3 2.0|
Lumbar, Infiltration Cellular, | | |
Plasma Cell | 2 2 2 2 2 | 8 2.0|
Lumbar, Infiltration Cellular, | | |
Histiocyte | | 1 3.0|
Mediastinal, Infiltration Cellular, | | |
Plasma Cell | 3 2 | 2 2.5|
Pancreatic, Hematopoietic Cell | | |
Proliferation | 2 | 1 2.0|
Renal, Hematopoietic Cell | | |
Proliferation | 2 2 | 2 2.0|
Renal, Hemorrhage | 3 | 1 3.0|
Renal, Infiltration Cellular, Plasma | | |
Cell | 2 2 2 2 2 2 | 8 2.0|
Renal, Infiltration Cellular, | | |
Histiocyte | | 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + +| 20 |
Hematopoietic Cell Proliferation | 2 | 2 2.0|
Hemorrhage | | 1 2.0|
Infiltration Cellular, Plasma Cell | 2 2 | 3 2.0|
Infiltration Cellular, Histiocyte | 2 | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + +| 25 |
Hematopoietic Cell Proliferation | 2 3 2 2 3 3 2 2 3 2 | 15 2.5|
Hemorrhage | 3 | 1 3.0|
Thrombosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + M + + + +| 12 |
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | + + + + + + + + + M| 14 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + +| 16 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + +| 14 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + +| 15 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 16
NTP Experiment-Test: 05030-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROBENECID Date: 04/29/97
Route: GAVAGE Time: 15:49:50
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 5| 5| 0| 7| 7| 5| 5| 7| 7| 6| 6| 6| 7| 7| 7| 7| 6| 7| 7| 6| 6| 1| |
DAY ON TEST | 3| 3| 3| 7| 4| 2| 3| 3| 5| 3| 3| 3| 7| 4| 2| 3| 3| 3| 3| 8| 3| 3| 9| 4| 0| |
| 2| 2| 2| 0| 7| 9| 2| 2| 0| 6| 2| 2| 4| 4| 7| 2| 2| 2| 2| 6| 2| 2| 4| 6| 8| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| A |
.1 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
LF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
NERVOUS SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + +| 23 |
Hemorrhage | 2 | 1 2.0|
Infiltration Cellular, Histiocyte | 2 | 1 2.0|
Inflammation, Chronic Active | 2 2 | 2 2.0|
Pleura, Abscess | 3 | 2 3.5|
__________________________________________________________________________|____________|
Nose | + + + + + + + + +| 13 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + +| 43 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 1 |
__________________________________________________________________________|____________|
Harderian Gland | + | 1 |
Mineralization | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + +| 19 |
Inflammation, Chronic Active | | 1 1.0|
Cortex, Mineralization | 1 | 1 1.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + +| 13 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 17
NTP Experiment-Test: 05030-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROBENECID Date: 04/29/97
Route: GAVAGE Time: 15:49:50
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 4| 4| 4| 7| 7| 7| 7| 5| 7| 7| 7| 6| 5| 7| 7| 7| 7| 5|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 8| 7| 0| 3| 3| 3| 1| 8| 3| 3| 3| 4| 8| 3| 3| 3| 1| 6|
| 0| 0| 0| 0| 0| 0| 0| 6| 5| 8| 0| 0| 0| 6| 5| 0| 0| 0| 3| 6| 0| 0| 0| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
.4 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + M M + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + M + + + M A + + M + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + M + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + A + + + + + + A + + + A A + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + A + + + + + +|
Lymphoid Nodule, Hyperplasia | |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + M + + + A + + + + + + + + + + A A + + + + +|
Lymphoid Nodule, Hyperplasia | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + M + + + + + +|
Angiectasis | |
Basophilic Focus | 2 |
Cyst | |
Eosinophilic Focus | 2 |
Fatty Change, Focal | 2 |
Fatty Change | |
Hematopoietic Cell Proliferation | 1 1 2 2 2|
Necrosis, Coagulative | |
Necrosis | 2 |
__________________________________________________________________________|
Mesentery | + + + + + +|
Inflammation, Acute | 3 3 2 2 3|
Fat, Necrosis | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + M M + + + + +|
Acinus, Atrophy | |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + M + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + M + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + M + + + + + +|
Acanthosis | 2 2 |
Hyperkeratosis | 3 1 |
Inflammation, Acute | |
Inflammation, Chronic Active | 2 |
Necrosis | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + M + + + + + +|
Hyperplasia | |
Inflammation, Chronic Active | |
Necrosis | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + M + + + + + +|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
_____________________________________________________________________________________________________________________|
Page 18
NTP Experiment-Test: 05030-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROBENECID Date: 04/29/97
Route: GAVAGE Time: 15:49:50
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 4| 4| 4| 7| 7| 7| 7| 5| 7| 7| 7| 6| 5| 7| 7| 7| 7| 5|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 8| 7| 0| 3| 3| 3| 1| 8| 3| 3| 3| 4| 8| 3| 3| 3| 1| 6|
| 0| 0| 0| 0| 0| 0| 0| 6| 5| 8| 0| 0| 0| 6| 5| 0| 0| 0| 3| 6| 0| 0| 0| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
.4 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + M + + + + + +|
Capsule, Hyperplasia | 2 2 2 2 3 3 2 2 2 2 2 2 2 2 3 2 2 2 2 2 2 2 2|
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + M + + + + + +|
Hematopoietic Cell Proliferation | 1 2 |
Hyperplasia | 2 2 2 2 3 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2|
Hypertrophy | 1 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + M + + + M + + + + + + M M + + + + +|
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + M M + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + + M + + + + + M M + + + M M M M M M M + + M + M|
__________________________________________________________________________|
Pituitary Gland | + + + M + + + + + + + + + + + M + + M + + + + + M|
Pars Distalis, Angiectasis | 2 1 |
Pars Distalis, Cyst | |
Pars Distalis, Hyperplasia, Focal | 2 |
Pars Distalis, Hyperplasia | 2 2 2 2 2 |
Pars Intermedia, Hyperplasia | 2 |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + M + + + M + + + + + +|
Infiltration Cellular, Lymphocyte | 1 |
Follicle, Cyst | X |
Follicular Cell, Hyperplasia | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Clitoral Gland | |
__________________________________________________________________________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +|
Abscess | 3 4 4 4 3 4 4|
Angiectasis | 2 |
Cyst | X X X |
Degeneration, Cystic | 2 2 |
Hemorrhage | 4 3 |
Inflammation, Acute | 2 |
__________________________________________________________________________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 2 |
Hemorrhage | |
Inflammation, Acute | 1 2 |
Mineralization | |
Necrosis | |
Endometrium, Hyperplasia | 2 4 3 3 3 3 2 2 3 2 2 2 3 2 2|
__________________________________________________________________________|
Vagina | |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + + + + + + + + + + + |
_____________________________________________________________________________________________________________________|
Page 19
NTP Experiment-Test: 05030-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROBENECID Date: 04/29/97
Route: GAVAGE Time: 15:49:50
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 4| 4| 4| 7| 7| 7| 7| 5| 7| 7| 7| 6| 5| 7| 7| 7| 7| 5|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 8| 7| 0| 3| 3| 3| 1| 8| 3| 3| 3| 4| 8| 3| 3| 3| 1| 6|
| 0| 0| 0| 0| 0| 0| 0| 6| 5| 8| 0| 0| 0| 6| 5| 0| 0| 0| 3| 6| 0| 0| 0| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
.4 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + M + + + + + +|
Myelofibrosis | 2 |
__________________________________________________________________________|
Lymph Node | + + + M + + + + + + + + + + + M + + M + + + + + +|
Hematopoietic Cell Proliferation | |
Lumbar, Hematopoietic Cell | |
Proliferation | 3 4 |
Lumbar, Infiltration Cellular, | |
Plasma Cell | 3 2 2 3|
Mandibular, Hematopoietic Cell | |
Proliferation | 3 |
Mediastinal, Hematopoietic Cell | |
Proliferation | 3 |
Mediastinal, Infiltration Cellular, | |
Plasma Cell | 3 |
Pancreatic, Angiectasis | |
Pancreatic, Hematopoietic Cell | |
Proliferation | |
Renal, Hematopoietic Cell | |
Proliferation | 3 3 |
Renal, Infiltration Cellular, Plasma | |
Cell | 2 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + M + + + + + + + + + + + M + + M + + + + + +|
Angiectasis | 1 1 |
Depletion Lymphoid | 2 |
Hematopoietic Cell Proliferation | 2 3 3 1|
Infiltration Cellular, Plasma Cell | 2|
Necrosis | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + M + + + + + +|
Angiectasis | 3 |
Atrophy | |
Hematopoietic Cell Proliferation | 2 2 3 3 3 2 2 2 2 2 2 2 2 3 2 4 3|
Lymphoid Follicle, Hyperplasia | 2 2 |
__________________________________________________________________________|
Thymus | + + + + + + + M + + + + + + + + + + M M + + + + +|
Depletion Lymphoid | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M + + M M M + M + M + M M M + + + + M + + + + + +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bacterium | 2 |
Cyst Epithelial Inclusion | X |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + M + + + + + +|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 20
NTP Experiment-Test: 05030-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROBENECID Date: 04/29/97
Route: GAVAGE Time: 15:49:50
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 7| 4| 4| 4| 7| 7| 7| 7| 5| 7| 7| 7| 6| 5| 7| 7| 7| 7| 5|
DAY ON TEST | 3| 3| 3| 3| 3| 3| 3| 8| 7| 0| 3| 3| 3| 1| 8| 3| 3| 3| 4| 8| 3| 3| 3| 1| 6|
| 0| 0| 0| 0| 0| 0| 0| 6| 5| 8| 0| 0| 0| 6| 5| 0| 0| 0| 3| 6| 0| 0| 0| 7| 7|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|
.4 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + M + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + M + + + + + +|
Bacterium | 1 |
Hemorrhage | 2 |
Infiltration Cellular, Histiocyte | |
Inflammation, Acute | 1 3 1 2 |
Pleura, Inflammation, Acute | 3 2 |
__________________________________________________________________________|
Nose | + + + + + + + + + + + + + + + + + + M + + M + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + M + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | +|
__________________________________________________________________________|
Harderian Gland | +|
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + M + + + + + +|
Inflammation, Acute | |
Cortex, Mineralization | 1 |
Papilla, Mineralization | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + M + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 21
NTP Experiment-Test: 05030-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROBENECID Date: 04/29/97
Route: GAVAGE Time: 15:49:50
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 4| 3| 7| 7| 7| 7| 5| 7| 7| 7| 6| 5| 7| 7| 5| 3| 3| |
DAY ON TEST | 3| 3| 3| 3| 7| 3| 3| 3| 2| 0| 3| 3| 3| 3| 2| 3| 3| 3| 0| 1| 3| 3| 8| 4| 4| |
| 0| 0| 0| 0| 2| 1| 1| 1| 2| 3| 1| 1| 1| 0| 7| 1| 1| 1| 5| 4| 1| 1| 3| 3| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
.4 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + A| 45 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + A| 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + A + + + + + + + + + + + + + + + + + + + A| 47 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + A| 49 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + A + + + + + + + + + + + + + + + + + + + A| 46 |
__________________________________________________________________________|____________|
Intestine Small | + + + + A + + + + + + + + + + + + + + + + + + + A| 47 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + A + + + + + + + + + + + + + + + + + + + A| 44 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + M + A + + + + + + + + + + + + + + + + + + + A| 46 |
Lymphoid Nodule, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + A + + + + + + + + + + + + + + + + + + + A| 44 |
Lymphoid Nodule, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Angiectasis | 1 3 | 2 2.0|
Basophilic Focus | X | 2 2.0|
Cyst | X X | 2 |
Eosinophilic Focus | X | 2 2.0|
Fatty Change, Focal | 1 | 2 1.5|
Fatty Change | 1| 1 1.0|
Hematopoietic Cell Proliferation | 2 2 | 7 1.7|
Necrosis, Coagulative | 1 | 1 1.0|
Necrosis | 1 2 2 | 4 1.8|
__________________________________________________________________________|____________|
Mesentery | + + + | 9 |
Inflammation, Acute | 3 3 3 | 8 2.8|
Fat, Necrosis | | 1 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + M +| 47 |
Acinus, Atrophy | 2 | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Acanthosis | 2 3 2 3 2 | 7 2.3|
Hyperkeratosis | 2 2 1 2 3 2 2 | 9 2.0|
Inflammation, Acute | 2 | 1 2.0|
Inflammation, Chronic Active | 2 | 2 2.0|
Necrosis | 1 | 1 1.0|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + A + + + + + + + + + + + + + + + + + + + +| 48 |
Hyperplasia | 2 | 1 2.0|
Inflammation, Chronic Active | 2 | 1 2.0|
Necrosis | 1 | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 22
NTP Experiment-Test: 05030-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROBENECID Date: 04/29/97
Route: GAVAGE Time: 15:49:50
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 4| 3| 7| 7| 7| 7| 5| 7| 7| 7| 6| 5| 7| 7| 5| 3| 3| |
DAY ON TEST | 3| 3| 3| 3| 7| 3| 3| 3| 2| 0| 3| 3| 3| 3| 2| 3| 3| 3| 0| 1| 3| 3| 8| 4| 4| |
| 0| 0| 0| 0| 2| 1| 1| 1| 2| 3| 1| 1| 1| 0| 7| 1| 1| 1| 5| 4| 1| 1| 3| 3| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
.4 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Capsule, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 | 43 2.1|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hematopoietic Cell Proliferation | 2 2 1 | 5 1.6|
Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 | 39 2.0|
Hypertrophy | | 1 1.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + M + M + + + + + + + + + + + + + + + + + + + +| 44 |
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + M + + M +| 46 |
__________________________________________________________________________|____________|
Parathyroid Gland | + M M + M M + + + M M + M + M + + + + M + + M + +| 28 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + M M + + + M + + + + + + + + M M + + M M M| 38 |
Pars Distalis, Angiectasis | 2 1 2 | 5 1.6|
Pars Distalis, Cyst | X | 1 |
Pars Distalis, Hyperplasia, Focal | | 1 2.0|
Pars Distalis, Hyperplasia | 2 2 2 | 8 2.0|
Pars Intermedia, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Infiltration Cellular, Lymphocyte | | 1 1.0|
Follicle, Cyst | | 1 |
Follicular Cell, Hyperplasia | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Clitoral Gland | + | 1 |
__________________________________________________________________________|____________|
Ovary | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Abscess | 4 4 4 4 | 11 3.8|
Angiectasis | 1 | 2 1.5|
Cyst | X X X X X X| 9 |
Degeneration, Cystic | 3 2 3 3 4 | 7 2.7|
Hemorrhage | | 2 3.5|
Inflammation, Acute | | 1 2.0|
__________________________________________________________________________|____________|
Uterus | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 23
NTP Experiment-Test: 05030-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROBENECID Date: 04/29/97
Route: GAVAGE Time: 15:49:50
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 4| 3| 7| 7| 7| 7| 5| 7| 7| 7| 6| 5| 7| 7| 5| 3| 3| |
DAY ON TEST | 3| 3| 3| 3| 7| 3| 3| 3| 2| 0| 3| 3| 3| 3| 2| 3| 3| 3| 0| 1| 3| 3| 8| 4| 4| |
| 0| 0| 0| 0| 2| 1| 1| 1| 2| 3| 1| 1| 1| 0| 7| 1| 1| 1| 5| 4| 1| 1| 3| 3| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
.4 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
Hemorrhage | 3 | 1 3.0|
Inflammation, Acute | | 2 1.5|
Mineralization | 2 | 1 2.0|
Necrosis | 2 | 1 2.0|
Endometrium, Hyperplasia | 2 2 2 3 2 2 2 2 2 2 3 2 2 2 2 2 2 2 | 33 2.3|
__________________________________________________________________________|____________|
Vagina | + | 1 |
Inflammation, Chronic Active | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + + + + + + + + | 22 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Myelofibrosis | 3 3 3 3 | 5 2.8|
__________________________________________________________________________|____________|
Lymph Node | + + + + + + + + + + + + + + + M + + + + + + + + A| 45 |
Hematopoietic Cell Proliferation | 2 | 1 2.0|
Lumbar, Hematopoietic Cell | | |
Proliferation | 3 2 2 2 | 6 2.7|
Lumbar, Infiltration Cellular, | | |
Plasma Cell | 3 | 5 2.6|
Mandibular, Hematopoietic Cell | | |
Proliferation | 2 | 2 2.5|
Mediastinal, Hematopoietic Cell | | |
Proliferation | | 1 3.0|
Mediastinal, Infiltration Cellular, | | |
Plasma Cell | | 1 3.0|
Pancreatic, Angiectasis | 3 | 1 3.0|
Pancreatic, Hematopoietic Cell | | |
Proliferation | 2 2 | 2 2.0|
Renal, Hematopoietic Cell | | |
Proliferation | 2 2 | 4 2.5|
Renal, Infiltration Cellular, Plasma | | |
Cell | 3 | 3 2.3|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + + M + + + + M + + + A| 44 |
Angiectasis | 2 1 | 4 1.3|
Depletion Lymphoid | | 1 2.0|
Hematopoietic Cell Proliferation | 2 1 2 | 7 2.0|
Infiltration Cellular, Plasma Cell | 3 | 2 2.5|
Necrosis | 1 | 1 1.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Angiectasis | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 24
NTP Experiment-Test: 05030-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROBENECID Date: 04/29/97
Route: GAVAGE Time: 15:49:50
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 4| 3| 7| 7| 7| 7| 5| 7| 7| 7| 6| 5| 7| 7| 5| 3| 3| |
DAY ON TEST | 3| 3| 3| 3| 7| 3| 3| 3| 2| 0| 3| 3| 3| 3| 2| 3| 3| 3| 0| 1| 3| 3| 8| 4| 4| |
| 0| 0| 0| 0| 2| 1| 1| 1| 2| 3| 1| 1| 1| 0| 7| 1| 1| 1| 5| 4| 1| 1| 3| 3| 3| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE FEMALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| A |
.4 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
HF | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
Atrophy | 3 | 1 3.0|
Hematopoietic Cell Proliferation | 2 2 2 3 3 3 2 2 2 3 3 2 4 4 2 | 32 2.5|
Lymphoid Follicle, Hyperplasia | 2 | 3 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + M + + + M + + + + + + + + + + M + + M M +| 42 |
Depletion Lymphoid | | 1 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M + + + + + + + + + M + + + + M M + + M + + M M| 32 |
__________________________________________________________________________|____________|
Skin | M + + + + + + + + + + + + + M + + + + + + + + + +| 48 |
Bacterium | | 1 2.0|
Cyst Epithelial Inclusion | | 1 |
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Bacterium | 2 | 2 1.5|
Hemorrhage | | 1 2.0|
Infiltration Cellular, Histiocyte | 1 | 1 1.0|
Inflammation, Acute | | 4 1.8|
Pleura, Inflammation, Acute | | 2 2.5|
__________________________________________________________________________|____________|
Nose | + + + + + + + M + + + + + M + + + + + + + + + + +| 46 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 2 |
__________________________________________________________________________|____________|
Harderian Gland | + | 2 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Inflammation, Acute | 2 | 1 2.0|
Cortex, Mineralization | | 1 1.0|
Papilla, Mineralization | 1 | 2 1.5|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + A + + + + + + + + + + + + + + + + + + + A| 47 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 25
NTP Experiment-Test: 05030-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROBENECID Date: 04/29/97
Route: GAVAGE Time: 15:49:50
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 0| 7| 7| 6| 7| 7| 7| 7| 5| 3| 7| 7| 7| 7| 3| 7| 7| 7| 6| 5|
DAY ON TEST | 3| 3| 3| 3| 3| 0| 3| 3| 0| 3| 3| 3| 3| 4| 9| 3| 3| 3| 3| 1| 3| 3| 3| 8| 2|
| 3| 2| 2| 2| 3| 3| 2| 2| 6| 2| 2| 2| 2| 1| 0| 2| 2| 2| 3| 0| 2| 2| 2| 0| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + M + + + + + + + + + M + + + + + + + + + M|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + + + + + + + + + + + + + A|
Hemorrhage | |
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + + + + + + M|
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + M + + + + + + +|
Epithelium, Hyperplasia | 2 |
Lymphoid Nodule, Hyperplasia | 3 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + + + + + + A|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fatty Change, Focal | 1|
Necrosis | 3 2 |
__________________________________________________________________________|
Mesentery | + |
Fat, Inflammation, Chronic Active | 3 |
Fat, Mineralization | 1 |
__________________________________________________________________________|
Pancreas | + M + + + + + + + + + + + + + + + + + + + + + + M|
Acinus, Atrophy | 2 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Submucosa, Inflammation, Chronic | |
Active | 1 |
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis, Focal | |
Acanthosis | 2 |
Hyperkeratosis | 4 3 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + A|
Hyperplasia | |
Inflammation, Chronic Active | |
Mineralization | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cardiomyopathy | |
Inflammation, Chronic Active | |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Capsule, Hyperplasia, Focal | 3 |
Capsule, Hyperplasia | 2 2 2 2 2 2 3 1 2 2 |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 26
NTP Experiment-Test: 05030-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROBENECID Date: 04/29/97
Route: GAVAGE Time: 15:49:50
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 0| 7| 7| 6| 7| 7| 7| 7| 5| 3| 7| 7| 7| 7| 3| 7| 7| 7| 6| 5|
DAY ON TEST | 3| 3| 3| 3| 3| 0| 3| 3| 0| 3| 3| 3| 3| 4| 9| 3| 3| 3| 3| 1| 3| 3| 3| 8| 2|
| 3| 2| 2| 2| 3| 3| 2| 2| 6| 2| 2| 2| 2| 1| 0| 2| 2| 2| 3| 0| 2| 2| 2| 0| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Accessory Adrenal Cortical Nodule | |
Hyperplasia | 2 2 2 2 2 2 2 3 1 2 2 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 2 2 |
__________________________________________________________________________|
Islets, Pancreatic | + M + + + + + + + + + + + + + + + + + + + + + + M|
Hyperplasia | 1 |
__________________________________________________________________________|
Parathyroid Gland | + + M + + M + + + + + + M M M M M + + + + + + + M|
__________________________________________________________________________|
Pituitary Gland | + + + + + + + + M + + + + + + M M M M M M + + + +|
Pars Distalis, Hyperplasia, | |
Adenomatous | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + M + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + +|
Dilatation | 2 2 2|
Inflammation, Acute | |
Inflammation, Chronic Active | 2 2 2 |
Necrosis | 1 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 3 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | |
Inflammation, Acute | |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Spermatocele | |
Seminiferous Tubule, Atrophy | |
Seminiferous Tubule, Mineralization | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + + + + + + + M + + + + + + M + + M|
Axillary, Infiltration Cellular, | |
Plasma Cell | |
Axillary, Infiltration Cellular, | |
Lymphocyte | 2 |
Inguinal, Infiltration Cellular, | |
Lymphocyte | 2 |
Lumbar, Infiltration Cellular, | |
Plasma Cell | |
_____________________________________________________________________________________________________________________|
Page 27
NTP Experiment-Test: 05030-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROBENECID Date: 04/29/97
Route: GAVAGE Time: 15:49:50
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 0| 7| 7| 6| 7| 7| 7| 7| 5| 3| 7| 7| 7| 7| 3| 7| 7| 7| 6| 5|
DAY ON TEST | 3| 3| 3| 3| 3| 0| 3| 3| 0| 3| 3| 3| 3| 4| 9| 3| 3| 3| 3| 1| 3| 3| 3| 8| 2|
| 3| 2| 2| 2| 3| 3| 2| 2| 6| 2| 2| 2| 2| 1| 0| 2| 2| 2| 3| 0| 2| 2| 2| 0| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Lumbar, Infiltration Cellular, | |
Lymphocyte | 2 |
Mediastinal, Infiltration Cellular, | |
Histiocyte | 2 |
Renal, Infiltration Cellular, Plasma | |
Cell | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + + + + + + + M + + + + + + M + + M|
Angiectasis | 2 2 2 3 3 1 2 2 2 2 |
Hematopoietic Cell Proliferation | 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Fibrosis | 3 |
Hematopoietic Cell Proliferation | 2 1 1 1 2 3 1 2 2 |
Hyperplasia, Lymphoid | 2 |
Lymphoid Follicle, Hyperplasia | 2 |
__________________________________________________________________________|
Thymus | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M M M M M M M M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + M + + + + + +|
Hyperplasia, Basal Cell | 1 |
Necrosis | 2 |
Inguinal, Fungus | 3 |
Inguinal, Inflammation, Chronic | |
Active | 3 |
Inguinal, Necrosis | 2 |
Prepuce, Inflammation, Chronic Active| 2 |
Prepuce, Necrosis | 1 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Joint, Hyperostosis | 2 |
Tarsal, Hyperostosis | 3 3 2 3 2 2 2 3 3 2 2 3 3 3 3 2 2 3 |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 1 1 1 |
Infiltration Cellular, Histiocyte | 3 |
Inflammation, Acute | 2 |
Alveolar Epithelium, Hyperplasia | 2 2 |
__________________________________________________________________________|
Nose | + + + + M + M + + + + + M + + + M + + + + + M + +|
_____________________________________________________________________________________________________________________|
Page 28
NTP Experiment-Test: 05030-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROBENECID Date: 04/29/97
Route: GAVAGE Time: 15:49:50
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 0| 7| 7| 6| 7| 7| 7| 7| 5| 3| 7| 7| 7| 7| 3| 7| 7| 7| 6| 5|
DAY ON TEST | 3| 3| 3| 3| 3| 0| 3| 3| 0| 3| 3| 3| 3| 4| 9| 3| 3| 3| 3| 1| 3| 3| 3| 8| 2|
| 3| 2| 2| 2| 3| 3| 2| 2| 6| 2| 2| 2| 2| 1| 0| 2| 2| 2| 3| 0| 2| 2| 2| 0| 2|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
VEHICLE | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Edema | |
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Eye | + + |
__________________________________________________________________________|
Harderian Gland | + + |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bacterium | |
Cortex, Mineralization | 1 1 1 1 3 1 1 1 1 2|
Papilla, Mineralization | 1 |
Papilla, Necrosis | 1 |
Renal Tubule, Regeneration | |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + M|
Calculus Micro Observation Only | |
Mineralization | 1 |
_____________________________________________________________________________________________________________________|
Page 29
NTP Experiment-Test: 05030-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROBENECID Date: 04/29/97
Route: GAVAGE Time: 15:49:50
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 5| 4| |
DAY ON TEST | 3| 3| 3| 3| 8| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 7| 1| |
| 2| 2| 3| 3| 2| 2| 2| 2| 2| 4| 2| 2| 2| 2| 2| 3| 3| 2| 3| 2| 3| 3| 3| 6| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + M + + + + M + + + M +| 44 |
__________________________________________________________________________|____________|
Gallbladder | + + + + + M + + + + + + + + + + + + + M + + + + M| 46 |
Hemorrhage | 3 | 1 3.0|
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + A + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + A + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + A + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + A + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + A + + + + +| 49 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + A + + + + +| 48 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + + A + + + + +| 48 |
Epithelium, Hyperplasia | | 1 2.0|
Lymphoid Nodule, Hyperplasia | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + A + + + + +| 48 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Fatty Change, Focal | 1 | 2 1.0|
Necrosis | 2 2 | 4 2.3|
__________________________________________________________________________|____________|
Mesentery | | 1 |
Fat, Inflammation, Chronic Active | | 1 3.0|
Fat, Mineralization | | 1 1.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + A + + + + +| 47 |
Acinus, Atrophy | | 1 2.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + A + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + A + + + + +| 49 |
Submucosa, Inflammation, Chronic | | |
Active | | 1 1.0|
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + A + + + + +| 49 |
Acanthosis, Focal | 4 | 1 4.0|
Acanthosis | 1 | 2 1.5|
Hyperkeratosis | 2 2 1 2 1 | 7 2.1|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + A M + + + +| 47 |
Hyperplasia | 1 1 | 2 1.0|
Inflammation, Chronic Active | 2 2 1 | 3 1.7|
Mineralization | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + A + + + + +| 49 |
Cardiomyopathy | 2 | 1 2.0|
Inflammation, Chronic Active | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 30
NTP Experiment-Test: 05030-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROBENECID Date: 04/29/97
Route: GAVAGE Time: 15:49:50
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 5| 4| |
DAY ON TEST | 3| 3| 3| 3| 8| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 7| 1| |
| 2| 2| 3| 3| 2| 2| 2| 2| 2| 4| 2| 2| 2| 2| 2| 3| 3| 2| 3| 2| 3| 3| 3| 6| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + M + + + + + + + + + + + + + + A + + + + +| 48 |
Capsule, Hyperplasia, Focal | | 1 3.0|
Capsule, Hyperplasia | 2 2 2 2 1 1 2 2 2 2 2 2 1 | 23 1.9|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + M + + + + + + + + + + + + + + A + + + + +| 48 |
Accessory Adrenal Cortical Nodule | X | 1 |
Hyperplasia | 2 2 2 2 1 2 2 2 2 2 2 | 22 2.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + M + + + + + + + + + + + + + + A + + + + +| 48 |
Hyperplasia | 2 3 1 | 7 1.9|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + M + + + + +| 47 |
Hyperplasia | | 1 1.0|
__________________________________________________________________________|____________|
Parathyroid Gland | M M M M + M + M + + + M + M + + + + M M + + + M +| 31 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + M + M + + + + + + + + + M M M + + + +| 38 |
Pars Distalis, Hyperplasia, | | |
Adenomatous | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + A + + + + +| 48 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + A + + + + +| 49 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + | 12 |
Dilatation | 3 3 | 5 2.4|
Inflammation, Acute | 3 | 1 3.0|
Inflammation, Chronic Active | 3 | 4 2.3|
Necrosis | 3 3 | 4 2.3|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + M + + + + + + + + + A + + + + +| 48 |
Inflammation, Acute | 3| 2 3.0|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + A + + + + +| 49 |
Hemorrhage | 2| 1 2.0|
Inflammation, Acute | 2| 1 2.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + A + + + + +| 49 |
Atrophy | | 1 3.0|
Spermatocele | X | 1 |
Seminiferous Tubule, Atrophy | 1 | 1 1.0|
Seminiferous Tubule, Mineralization | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 31
NTP Experiment-Test: 05030-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROBENECID Date: 04/29/97
Route: GAVAGE Time: 15:49:50
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 5| 4| |
DAY ON TEST | 3| 3| 3| 3| 8| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 7| 1| |
| 2| 2| 3| 3| 2| 2| 2| 2| 2| 4| 2| 2| 2| 2| 2| 3| 3| 2| 3| 2| 3| 3| 3| 6| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + M + + + + +| 49 |
__________________________________________________________________________|____________|
Lymph Node | + + + M + + + + + + + + + + + + + M + M + + + + +| 44 |
Axillary, Infiltration Cellular, | | |
Plasma Cell | 3 | 1 3.0|
Axillary, Infiltration Cellular, | | |
Lymphocyte | | 1 2.0|
Inguinal, Infiltration Cellular, | | |
Lymphocyte | | 1 2.0|
Lumbar, Infiltration Cellular, | | |
Plasma Cell | 2 2| 2 2.0|
Lumbar, Infiltration Cellular, | | |
Lymphocyte | | 1 2.0|
Mediastinal, Infiltration Cellular, | | |
Histiocyte | | 1 2.0|
Renal, Infiltration Cellular, Plasma | | |
Cell | 2| 1 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + M + + + + + + + + + + + + + M + M + + + + +| 44 |
Angiectasis | 2 2 2 2 1 2 2 2 2 3 | 20 2.1|
Hematopoietic Cell Proliferation | 1 1 2 | 4 1.5|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + M + + + + +| 49 |
Fibrosis | | 1 3.0|
Hematopoietic Cell Proliferation | 1 2 2 1 1 2 2 2 3 2| 19 1.7|
Hyperplasia, Lymphoid | | 1 2.0|
Lymphoid Follicle, Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Thymus | + + + + + + + + + + + + + + M + + + + M + + M + +| 47 |
Atrophy | | 1 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M M M + M M M M M + M M M M M M M + M + M M| 4 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + M + + + + + A + + + + +| 47 |
Hyperplasia, Basal Cell | | 1 1.0|
Necrosis | | 1 2.0|
Inguinal, Fungus | | 1 3.0|
Inguinal, Inflammation, Chronic | | |
Active | | 1 3.0|
Inguinal, Necrosis | | 1 2.0|
Prepuce, Inflammation, Chronic Active| 2 | 2 2.0|
Prepuce, Necrosis | 2 | 2 1.5|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 32
NTP Experiment-Test: 05030-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROBENECID Date: 04/29/97
Route: GAVAGE Time: 15:49:50
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 5| 4| |
DAY ON TEST | 3| 3| 3| 3| 8| 3| 3| 3| 3| 1| 3| 3| 3| 3| 3| 3| 3| 3| 3| 8| 3| 3| 3| 7| 1| |
| 2| 2| 3| 3| 2| 2| 2| 2| 2| 4| 2| 2| 2| 2| 2| 3| 3| 2| 3| 2| 3| 3| 3| 6| 0| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| A |
VEHICLE | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
MALE | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + M + + + + +| 49 |
Joint, Hyperostosis | | 1 2.0|
Tarsal, Hyperostosis | 3 3 4 3 3 3 3 2 3 3 3 3 3 4 3 3 3| 35 2.8|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + A + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + A + + + + +| 49 |
Hemorrhage | 2 1 3 | 6 1.5|
Infiltration Cellular, Histiocyte | 2 | 2 2.5|
Inflammation, Acute | 2| 2 2.0|
Alveolar Epithelium, Hyperplasia | 2 | 3 2.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + M + + + + + + M + M + + M + M + + +| 40 |
Edema | 2 | 1 2.0|
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + A + + + + +| 49 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Eye | + | 3 |
__________________________________________________________________________|____________|
Harderian Gland | + + | 4 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + A + + + + +| 49 |
Bacterium | 1| 1 1.0|
Cortex, Mineralization | 1 1 1 1 1 1 | 16 1.2|
Papilla, Mineralization | 1 | 2 1.0|
Papilla, Necrosis | | 1 1.0|
Renal Tubule, Regeneration | 2 | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + A + + + + +| 48 |
Calculus Micro Observation Only | X | 1 |
Mineralization | | 1 1.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 33
NTP Experiment-Test: 05030-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROBENECID Date: 04/29/97
Route: GAVAGE Time: 15:49:50
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 4| 2| 1| 0| 7| 7| 6| 5| 0| 7| 7| 4| 3| 7| 7| 7| 4| 3|
DAY ON TEST | 3| 3| 3| 3| 2| 3| 3| 3| 0| 4| 0| 3| 3| 8| 6| 0| 3| 0| 6| 9| 3| 3| 3| 2| 0|
| 1| 1| 1| 1| 5| 1| 5| 1| 8| 3| 3| 1| 1| 3| 1| 3| 1| 7| 3| 0| 1| 1| 1| 6| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
.1 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + M M + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + A + + + A M A + + + + A + + + + + + + A M|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + + + + + + + +|
Anus, Inflammation, Chronic Active | |
Anus, Necrosis | |
__________________________________________________________________________|
Intestine Large, Cecum | + + + + A + + + + + + + + + + M + + + + + + + A +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + + + + + + +|
Lymphoid Nodule, Hyperplasia | 2 |
__________________________________________________________________________|
Intestine Large, Rectum | + + + + A + + + + + + + + + + M + + M + + + + M +|
__________________________________________________________________________|
Intestine Small | + + + + + + + + A + + + + + + + + + + + + + + A +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + A + A + + + + M + + + + + + + A +|
Necrosis | |
__________________________________________________________________________|
Intestine Small, Ileum | + + + + A + + + A + M + + + + + + + + + + + + A +|
Lymphoid Nodule, Hyperplasia | 2 |
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + A + + + A M A + + + + M + + + + + + + A +|
Lymphoid Nodule, Hyperplasia | |
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Cyst | |
Fatty Change, Focal | 1 |
Hematopoietic Cell Proliferation | |
Necrosis, Coagulative | 1|
Necrosis | 2 2 |
__________________________________________________________________________|
Mesentery | + |
Fat, Necrosis | 2 |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acinus, Hypertrophy | 1 |
__________________________________________________________________________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +|
Acanthosis | 2 |
Hyperkeratosis | 2 2 |
Inflammation, Acute | 1|
Necrosis | 1 |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | |
Necrosis | |
Pigmentation | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 1 1 |
Inflammation, Chronic Active | 2 |
Thrombosis | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
_____________________________________________________________________________________________________________________|
Page 34
NTP Experiment-Test: 05030-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROBENECID Date: 04/29/97
Route: GAVAGE Time: 15:49:50
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 4| 2| 1| 0| 7| 7| 6| 5| 0| 7| 7| 4| 3| 7| 7| 7| 4| 3|
DAY ON TEST | 3| 3| 3| 3| 2| 3| 3| 3| 0| 4| 0| 3| 3| 8| 6| 0| 3| 0| 6| 9| 3| 3| 3| 2| 0|
| 1| 1| 1| 1| 5| 1| 5| 1| 8| 3| 3| 1| 1| 3| 1| 3| 1| 7| 3| 0| 1| 1| 1| 6| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
.1 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Capsule, Hyperplasia, Focal | 3 |
Capsule, Hyperplasia | 2 2 2 2 2 1 1 |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
Accessory Adrenal Cortical Nodule | |
Hemorrhage | 2 |
Hyperplasia | 2 2 2 2 2 1 1 |
__________________________________________________________________________|
Adrenal Gland, Medulla | M + + + M + + + + + M M + + + + + + + + + + + + +|
Hyperplasia | 1 1 2 2 3 |
__________________________________________________________________________|
Islets, Pancreatic | + + M + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Parathyroid Gland | + M M M M + M + + M + M + + + M M + + + + M + + +|
__________________________________________________________________________|
Pituitary Gland | + + + + M + + + + + + + + + + + M + + + + + + + M|
Pars Distalis, Cyst | X |
Pars Distalis, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
__________________________________________________________________________|
Tissue NOS | + |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + |
Dilatation | 3 |
Inflammation, Chronic | 3 |
Inflammation, Chronic Active | 3 |
Necrosis | 2 2 4 |
__________________________________________________________________________|
Prostate | M + + + + M + + + + + + + + + + + + + + + + + M +|
Inflammation, Acute | 3 3 |
Inflammation, Chronic Active | 3 3 |
Necrosis | |
Epithelium, Hyperplasia | 2 3 |
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Chronic Active | 3 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Seminiferous Tubule, Atrophy | 2 |
Seminiferous Tubule, Mineralization | 2 2 |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Blood | + + + + + + |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Lymph Node | + + + + + + + + M M + + + + + + + + + + + + + M +|
Axillary, Infiltration Cellular, | |
Plasma Cell | 3 2 |
_____________________________________________________________________________________________________________________|
Page 35
NTP Experiment-Test: 05030-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROBENECID Date: 04/29/97
Route: GAVAGE Time: 15:49:50
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 4| 2| 1| 0| 7| 7| 6| 5| 0| 7| 7| 4| 3| 7| 7| 7| 4| 3|
DAY ON TEST | 3| 3| 3| 3| 2| 3| 3| 3| 0| 4| 0| 3| 3| 8| 6| 0| 3| 0| 6| 9| 3| 3| 3| 2| 0|
| 1| 1| 1| 1| 5| 1| 5| 1| 8| 3| 3| 1| 1| 3| 1| 3| 1| 7| 3| 0| 1| 1| 1| 6| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
.1 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Lumbar, Hematopoietic Cell | |
Proliferation | 2|
Lumbar, Hyperplasia, Plasma Cell | |
Lumbar, Infiltration Cellular, | |
Plasma Cell | 3 3 2 2 |
Lumbar, Infiltration Cellular, | |
Histiocyte | |
Pancreatic, Hematopoietic Cell | |
Proliferation | |
Renal, Hematopoietic Cell | |
Proliferation | |
Renal, Infiltration Cellular, Plasma | |
Cell | 3 2 |
Renal, Infiltration Cellular, | |
Histiocyte | |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + + + + + + + M M + + + + + + + + + + + + + M +|
Angiectasis | 2 2 1 2 1 2 2 3 2 4 2 2 2 2 |
Hematopoietic Cell Proliferation | 2 2 3 2 |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Depletion Lymphoid | 2 2 |
Hematopoietic Cell Proliferation | 2 2 3 2 3 2 3 3 3|
__________________________________________________________________________|
Thymus | + + + M M M + + + M A + + + M + + + + + + + + M M|
Atrophy | |
Depletion Lymphoid | 3 4 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M M + M M M + M M + M M M M M M + M M +|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hemorrhage | 2 |
Inflammation, Acute | |
Inflammation, Chronic Active | |
Necrosis | 2 |
Prepuce, Acanthosis | |
Prepuce, Hemorrhage | 3 |
Prepuce, Inflammation, Chronic Active| 2 |
Prepuce, Necrosis | 3 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Tarsal, Hyperostosis | 3 3 3 3 3 3 2 3 3 3 2 3 3 3 3 3|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
Page 36
NTP Experiment-Test: 05030-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROBENECID Date: 04/29/97
Route: GAVAGE Time: 15:49:50
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 7| 7| 6| 4| 2| 1| 0| 7| 7| 6| 5| 0| 7| 7| 4| 3| 7| 7| 7| 4| 3|
DAY ON TEST | 3| 3| 3| 3| 2| 3| 3| 3| 0| 4| 0| 3| 3| 8| 6| 0| 3| 0| 6| 9| 3| 3| 3| 2| 0|
| 1| 1| 1| 1| 5| 1| 5| 1| 8| 3| 3| 1| 1| 3| 1| 3| 1| 7| 3| 0| 1| 1| 1| 6| 5|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|
.1 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM - cont | |
| |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Congestion | 4 3 |
Hemorrhage | 2 3 |
Infiltration Cellular, Histiocyte | |
Inflammation, Acute | 3 |
Alveolar Epithelium, Hyperplasia | 1 |
__________________________________________________________________________|
Nose | M + + + + + + + + M + + + M + + + + + + + + + M +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
__________________________________________________________________________|
Harderian Gland | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Atrophy | 3 |
Casts Protein | 2 |
Congestion | 2 |
Hydronephrosis | 3 |
Inflammation, Acute | 1 2 2 |
Inflammation, Chronic Active | 3 |
Cortex, Mineralization | 1 2 |
Papilla, Necrosis | 4 |
Renal Tubule, Casts Protein | 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + A + + + + + + + + + + + + + + + + + + + +|
Calculus Micro Observation Only | |
Inflammation, Acute | 2 |
Inflammation, Chronic Active | 3 2|
Necrosis | 3 |
Transitional Epithelium, Hyperplasia | 4 |
_____________________________________________________________________________________________________________________|
Page 37
NTP Experiment-Test: 05030-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROBENECID Date: 04/29/97
Route: GAVAGE Time: 15:49:50
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 6| 4| 2| 7| 7| 7| 6| 4| 7| 6| 5| 5| 4| 7| 7| 7| 6| 4| |
DAY ON TEST | 3| 3| 3| 1| 4| 3| 3| 4| 4| 3| 3| 3| 3| 4| 1| 3| 5| 8| 1| 9| 3| 3| 3| 4| 5| |
| 1| 1| 1| 7| 5| 1| 1| 6| 3| 9| 1| 1| 1| 5| 6| 1| 9| 9| 5| 2| 2| 2| 1| 5| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
.1 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Gallbladder | + + + + A + + + + + + + + + + + + + M A + + + + +| 40 |
__________________________________________________________________________|____________|
Intestine Large | + + + + + + + + + + + + + + + + + + + A + + + + +| 49 |
Anus, Inflammation, Chronic Active | 2 | 1 2.0|
Anus, Necrosis | 4 | 1 4.0|
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + + A + + + + +| 46 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + + A + + + + +| 49 |
Lymphoid Nodule, Hyperplasia | 2 | 2 2.0|
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + + + + + + + + + + + + + + + + A + + + + +| 45 |
__________________________________________________________________________|____________|
Intestine Small | + + + + + + + + + + + + + + + + + + + A + + + + +| 47 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + + A + + + + +| 45 |
Necrosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + + + + + + + + + + + + + + + A + + + + +| 44 |
Lymphoid Nodule, Hyperplasia | 2 | 2 2.0|
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + + A + + + + +| 43 |
Lymphoid Nodule, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Cyst | X | 1 |
Fatty Change, Focal | | 1 1.0|
Hematopoietic Cell Proliferation | 2 | 1 2.0|
Necrosis, Coagulative | | 1 1.0|
Necrosis | 3 2 2 2 2 3 | 8 2.3|
__________________________________________________________________________|____________|
Mesentery | + | 2 |
Fat, Necrosis | 2 | 2 2.0|
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acinus, Hypertrophy | 1 | 2 1.0|
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Acanthosis | 2 2 | 3 2.0|
Hyperkeratosis | 2 2 2 | 5 2.0|
Inflammation, Acute | | 1 1.0|
Necrosis | 2 2 | 3 1.7|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Hyperplasia | 1 | 1 1.0|
Necrosis | 2 1 | 2 1.5|
Pigmentation | 2 | 1 2.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 38
NTP Experiment-Test: 05030-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROBENECID Date: 04/29/97
Route: GAVAGE Time: 15:49:50
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 6| 4| 2| 7| 7| 7| 6| 4| 7| 6| 5| 5| 4| 7| 7| 7| 6| 4| |
DAY ON TEST | 3| 3| 3| 1| 4| 3| 3| 4| 4| 3| 3| 3| 3| 4| 1| 3| 5| 8| 1| 9| 3| 3| 3| 4| 5| |
| 1| 1| 1| 7| 5| 1| 1| 6| 3| 9| 1| 1| 1| 5| 6| 1| 9| 9| 5| 2| 2| 2| 1| 5| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
.1 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Acute | | 2 1.0|
Inflammation, Chronic Active | | 1 2.0|
Thrombosis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Capsule, Hyperplasia, Focal | 4 | 2 3.5|
Capsule, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1 | 22 1.9|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Accessory Adrenal Cortical Nodule | X | 1 |
Hemorrhage | | 1 2.0|
Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 1 | 23 1.9|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + + M + + + + + + + + + + + + + + M + +| 44 |
Hyperplasia | 2 2 1 2 1 | 10 1.7|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Parathyroid Gland | + + M M + M + + + + M + + + + + + + + + + + M + +| 35 |
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + + + + + + + + M + M + M + + + + + +| 44 |
Pars Distalis, Cyst | | 1 |
Pars Distalis, Hyperplasia | 1 | 1 1.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Tissue NOS | | 1 |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + A + +| 15 |
Dilatation | 2 3| 3 2.7|
Inflammation, Chronic | | 1 3.0|
Inflammation, Chronic Active | 2 2 2| 4 2.3|
Necrosis | 3 | 4 2.8|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + M + + + + + + + + + + + + + + +| 46 |
Inflammation, Acute | | 2 3.0|
Inflammation, Chronic Active | | 2 3.0|
Necrosis | 4| 1 4.0|
Epithelium, Hyperplasia | | 2 2.5|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Chronic Active | | 1 3.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 39
NTP Experiment-Test: 05030-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROBENECID Date: 04/29/97
Route: GAVAGE Time: 15:49:50
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 6| 4| 2| 7| 7| 7| 6| 4| 7| 6| 5| 5| 4| 7| 7| 7| 6| 4| |
DAY ON TEST | 3| 3| 3| 1| 4| 3| 3| 4| 4| 3| 3| 3| 3| 4| 1| 3| 5| 8| 1| 9| 3| 3| 3| 4| 5| |
| 1| 1| 1| 7| 5| 1| 1| 6| 3| 9| 1| 1| 1| 5| 6| 1| 9| 9| 5| 2| 2| 2| 1| 5| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
.1 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
GENITAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Seminiferous Tubule, Atrophy | 3 | 2 2.5|
Seminiferous Tubule, Mineralization | | 2 2.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Blood | + + + + + + + + | 14 |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Lymph Node | + + + + M + + M + + + + + + + + + + + + + + + + +| 45 |
Axillary, Infiltration Cellular, | | |
Plasma Cell | | 2 2.5|
Lumbar, Hematopoietic Cell | | |
Proliferation | 2 2 | 3 2.0|
Lumbar, Hyperplasia, Plasma Cell | 2 | 1 2.0|
Lumbar, Infiltration Cellular, | | |
Plasma Cell | 2 2 2 | 7 2.3|
Lumbar, Infiltration Cellular, | | |
Histiocyte | 2 | 1 2.0|
Pancreatic, Hematopoietic Cell | | |
Proliferation | 2 | 1 2.0|
Renal, Hematopoietic Cell | | |
Proliferation | 2 | 1 2.0|
Renal, Infiltration Cellular, Plasma | | |
Cell | | 2 2.5|
Renal, Infiltration Cellular, | | |
Histiocyte | 2 2 | 2 2.0|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | + + + + M + + M + M + + + + + + M M + + + + + + +| 42 |
Angiectasis | 2 2 3 2 2 | 19 2.1|
Hematopoietic Cell Proliferation | 3 3 | 6 2.5|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Depletion Lymphoid | | 2 2.0|
Hematopoietic Cell Proliferation | 2 3 2 2 3 4 2 2 2 3 2 2 2 2 2 2| 25 2.4|
__________________________________________________________________________|____________|
Thymus | + + + + A + + + M M + + + + + + M M M + + + + + +| 36 |
Atrophy | 2 | 1 2.0|
Depletion Lymphoid | 3 2| 4 3.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M M + M M + M M M M M M M M M M + M M M M M M| 8 |
__________________________________________________________________________|____________|
Skin | + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Hemorrhage | | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 40
NTP Experiment-Test: 05030-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROBENECID Date: 04/29/97
Route: GAVAGE Time: 15:49:50
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 6| 4| 2| 7| 7| 7| 6| 4| 7| 6| 5| 5| 4| 7| 7| 7| 6| 4| |
DAY ON TEST | 3| 3| 3| 1| 4| 3| 3| 4| 4| 3| 3| 3| 3| 4| 1| 3| 5| 8| 1| 9| 3| 3| 3| 4| 5| |
| 1| 1| 1| 7| 5| 1| 1| 6| 3| 9| 1| 1| 1| 5| 6| 1| 9| 9| 5| 2| 2| 2| 1| 5| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
.1 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM - cont | | |
| | |
Inflammation, Acute | 2 | 1 2.0|
Inflammation, Chronic Active | 2 | 1 2.0|
Necrosis | 3 | 2 2.5|
Prepuce, Acanthosis | 3 | 1 3.0|
Prepuce, Hemorrhage | | 1 3.0|
Prepuce, Inflammation, Chronic Active| | 1 2.0|
Prepuce, Necrosis | 2 3 | 3 2.7|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Tarsal, Hyperostosis | 2 3 4 2 4 3 3 4 2 4 3 4 3 3 3 3 3 | 33 3.0|
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Spinal Cord | + | 1 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Congestion | | 2 3.5|
Hemorrhage | | 2 2.5|
Infiltration Cellular, Histiocyte | 2 | 1 2.0|
Inflammation, Acute | 1 | 2 2.0|
Alveolar Epithelium, Hyperplasia | 1 | 2 1.0|
__________________________________________________________________________|____________|
Nose | + + + + + + + + + + + + + + + + + + + + + M + + +| 45 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Harderian Gland | + | 1 |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Atrophy | | 1 3.0|
Casts Protein | 2 2 | 3 2.0|
Congestion | | 1 2.0|
Hydronephrosis | | 1 3.0|
Inflammation, Acute | 4 | 4 2.3|
Inflammation, Chronic Active | | 1 3.0|
Cortex, Mineralization | 2 2| 4 1.8|
Papilla, Necrosis | 3 | 2 3.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 41
NTP Experiment-Test: 05030-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROBENECID Date: 04/29/97
Route: GAVAGE Time: 15:49:50
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 6| 4| 2| 7| 7| 7| 6| 4| 7| 6| 5| 5| 4| 7| 7| 7| 6| 4| |
DAY ON TEST | 3| 3| 3| 1| 4| 3| 3| 4| 4| 3| 3| 3| 3| 4| 1| 3| 5| 8| 1| 9| 3| 3| 3| 4| 5| |
| 1| 1| 1| 7| 5| 1| 1| 6| 3| 9| 1| 1| 1| 5| 6| 1| 9| 9| 5| 2| 2| 2| 1| 5| 2| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| A |
.1 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
LM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Renal Tubule, Casts Protein | | 1 2.0|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
Calculus Micro Observation Only | X X | 2 |
Inflammation, Acute | 2 | 2 2.0|
Inflammation, Chronic Active | | 2 2.5|
Necrosis | 2 2 | 3 2.3|
Transitional Epithelium, Hyperplasia | 1 | 2 2.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 42
NTP Experiment-Test: 05030-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROBENECID Date: 04/29/97
Route: GAVAGE Time: 15:49:50
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 4| 7| 7| 7| 6| 4| 7| 7| 7| 5| 3|
DAY ON TEST | 3| 3| 3| 3| 4| 3| 3| 3| 2| 6| 3| 3| 2| 2| 3| 3| 3| 3| 3| 0| 3| 1| 3| 1| 0|
| 1| 1| 1| 1| 6| 1| 1| 1| 2| 7| 1| 1| 5| 0| 8| 1| 1| 1| 4| 8| 1| 7| 1| 5| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
.4 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ALIMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Esophagus | + + + + + + + + + + + + + + + + + M M + + + + + +|
__________________________________________________________________________|
Gallbladder | + + + + + + + + + + + + M + + + + + A A + + + + +|
__________________________________________________________________________|
Intestine Large | + + + + + + + + + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Intestine Large, Cecum | + + + + + + + + + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Intestine Large, Colon | + + + + + + + + + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Intestine Large, Rectum | + M M + + + + + + + + + + + + + + + A + + + + + +|
Inflammation, Acute | 4 |
Necrosis | 3 |
__________________________________________________________________________|
Intestine Small | + + + + + + + + + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Intestine Small, Duodenum | + + + + + + + + + + + + + + + + + + A A + + + + +|
__________________________________________________________________________|
Intestine Small, Ileum | + + + + M + + + + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Intestine Small, Jejunum | + + + + + + + + + + + + + + + + + + A + + + + + +|
__________________________________________________________________________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | |
Clear Cell Focus | X X |
Cyst | X |
Fatty Change, Focal | |
Hematopoietic Cell Proliferation | 2 |
Hemorrhage | |
Mineralization | 1 |
Necrosis | 4 2 3 2 |
Pigmentation | 1 |
__________________________________________________________________________|
Mesentery | |
__________________________________________________________________________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Salivary Glands | + + + + + + M + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Stomach | + + + + + + + + + + + + + + M + + + M + + + + + +|
__________________________________________________________________________|
Stomach, Forestomach | + + + + + + + + + + + + + + M + + + M + + + + + +|
Acanthosis, Focal | |
Acanthosis | 1 |
Hyperkeratosis | 2 1 |
Inflammation, Chronic Active | |
Necrosis | |
__________________________________________________________________________|
Stomach, Glandular | + + + + + + + + + + + + + + M + + + M + + + + + +|
Hyperplasia | 1 |
Necrosis | |
_____________________________________________________________________________________________________________________|
CARDIOVASCULAR SYSTEM | |
| |
__________________________________________________________________________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +|
Mineralization | 2 |
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM | |
| |
__________________________________________________________________________|
Adrenal Gland | + + + + + + + + + + + + + + + + + + + + + + + + +|
Capsule, Hyperplasia | 2 2 2 2 2 2 2 1 2 2 2 1 2 2 1 2 2 2 1 |
__________________________________________________________________________|
Adrenal Gland, Cortex | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
Page 43
NTP Experiment-Test: 05030-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROBENECID Date: 04/29/97
Route: GAVAGE Time: 15:49:50
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 4| 7| 7| 7| 6| 4| 7| 7| 7| 5| 3|
DAY ON TEST | 3| 3| 3| 3| 4| 3| 3| 3| 2| 6| 3| 3| 2| 2| 3| 3| 3| 3| 3| 0| 3| 1| 3| 1| 0|
| 1| 1| 1| 1| 6| 1| 1| 1| 2| 7| 1| 1| 5| 0| 8| 1| 1| 1| 4| 8| 1| 7| 1| 5| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
.4 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
ENDOCRINE SYSTEM - cont | |
| |
Accessory Adrenal Cortical Nodule | X |
Hyperplasia | 2 2 2 2 2 2 1 2 2 1 2 2 2 2 2 1 |
Hypertrophy | 1 |
__________________________________________________________________________|
Adrenal Gland, Medulla | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 1 1 2 1 1 |
__________________________________________________________________________|
Islets, Pancreatic | + + + + + + + + + + + + + + + + + + + + + + + + +|
Hyperplasia | 2 1 |
__________________________________________________________________________|
Parathyroid Gland | M M + + + + M M + + M + + + + M + M M M M + + + M|
Cyst | |
Hyperplasia | 2 |
__________________________________________________________________________|
Pituitary Gland | + + + + + + + M + M + + + + + + + + + + + + + + +|
Pars Distalis, Hyperplasia | |
__________________________________________________________________________|
Thyroid Gland | + + + + + + + + + + + + + + + + + M M + + + + + +|
Cyst | |
_____________________________________________________________________________________________________________________|
GENERAL BODY SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
GENITAL SYSTEM | |
| |
__________________________________________________________________________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Preputial Gland | + + + + + + +|
Dilatation | 3 3 3 |
Inflammation, Acute | 3 2|
Inflammation, Chronic Active | |
Necrosis | 2 2 |
__________________________________________________________________________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 2 3|
__________________________________________________________________________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +|
Inflammation, Acute | 1 |
__________________________________________________________________________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +|
Interstitial Cell, Hyperplasia | 2 |
Seminiferous Tubule, Atrophy | |
Seminiferous Tubule, Mineralization | |
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM | |
| |
__________________________________________________________________________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 |
__________________________________________________________________________|
Lymph Node | + + M + M + + + + + + + M + + + + + M + + + + M +|
Axillary, Infiltration Cellular, | |
Plasma Cell | 3 |
Lumbar, Infiltration Cellular, | |
Plasma Cell | 3|
Lumbar, Inflammation, Acute | 2 |
Mandibular, Necrosis | |
_____________________________________________________________________________________________________________________|
Page 44
NTP Experiment-Test: 05030-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROBENECID Date: 04/29/97
Route: GAVAGE Time: 15:49:50
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 4| 7| 7| 7| 6| 4| 7| 7| 7| 5| 3|
DAY ON TEST | 3| 3| 3| 3| 4| 3| 3| 3| 2| 6| 3| 3| 2| 2| 3| 3| 3| 3| 3| 0| 3| 1| 3| 1| 0|
| 1| 1| 1| 1| 6| 1| 1| 1| 2| 7| 1| 1| 5| 0| 8| 1| 1| 1| 4| 8| 1| 7| 1| 5| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
.4 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
HEMATOPOIETIC SYSTEM - cont | |
| |
Mediastinal, Angiectasis | |
Mediastinal, Hematopoietic Cell | |
Proliferation | |
Renal, Infiltration Cellular, Plasma | |
Cell | 2 |
__________________________________________________________________________|
Lymph Node, Mesenteric | + + M + M + + + + M + + M + + + + + M + + + + M +|
Angiectasis | 2 2 3 2 2 1 3 |
Hematopoietic Cell Proliferation | 2 2 1 3 2 |
Necrosis | |
__________________________________________________________________________|
Spleen | + + + + + + + + + + + + + + + + + + + + + + + + +|
Angiectasis | 1 1 |
Atrophy | 3 |
Depletion Lymphoid | |
Hematopoietic Cell Proliferation | 3 2 2 2 3 2 2 2 2 2 3 3 2 2 3|
Necrosis | 1 |
__________________________________________________________________________|
Thymus | + + + + M + + + + + + + + + M + + + M + M + + + M|
Atrophy | |
Depletion Lymphoid | 2 |
_____________________________________________________________________________________________________________________|
INTEGUMENTARY SYSTEM | |
| |
__________________________________________________________________________|
Mammary Gland | M M M M M M + M M M M M + M M M M M M M M M M M M|
__________________________________________________________________________|
Skin | + + + + + + + + + + + + + + M + + + + + + + + + +|
Prepuce, Hemorrhage | |
Prepuce, Inflammation, Acute | |
Prepuce, Necrosis | 4|
Subcutaneous Tissue, Mineralization | |
Subcutaneous Tissue, Necrosis | 2 |
_____________________________________________________________________________________________________________________|
MUSCULOSKELETAL SYSTEM | |
| |
__________________________________________________________________________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +|
Tarsal, Hyperostosis | 3 3 4 3 3 2 3 2 4 2 3 4 3 4 3 3 2 3|
__________________________________________________________________________|
Skeletal Muscle | |
_____________________________________________________________________________________________________________________|
NERVOUS SYSTEM | |
| |
__________________________________________________________________________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +|
__________________________________________________________________________|
Spinal Cord | |
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM | |
| |
__________________________________________________________________________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +|
Bacterium | |
Congestion | 2 |
Hemorrhage | 2 1 2 |
Infiltration Cellular, Histiocyte | 2 3 |
Inflammation, Acute | 2 3|
_____________________________________________________________________________________________________________________|
Page 45
NTP Experiment-Test: 05030-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROBENECID Date: 04/29/97
Route: GAVAGE Time: 15:49:50
_____________________________________________________________________________________________________________________
| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 4| 7| 7| 7| 6| 4| 7| 7| 7| 5| 3|
DAY ON TEST | 3| 3| 3| 3| 4| 3| 3| 3| 2| 6| 3| 3| 2| 2| 3| 3| 3| 3| 3| 0| 3| 1| 3| 1| 0|
| 1| 1| 1| 1| 6| 1| 1| 1| 2| 7| 1| 1| 5| 0| 8| 1| 1| 1| 4| 8| 1| 7| 1| 5| 4|
_____________________________________________________________________________________________________________________|
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|
.4 G/KG | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|
HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|
_____________________________________________________________________________________________________________________|
RESPIRATORY SYSTEM - cont | |
| |
Necrosis | |
Pigmentation | |
__________________________________________________________________________|
Nose | + + + + + + + + M M + + + + + + + + M + + + + + +|
__________________________________________________________________________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +|
_____________________________________________________________________________________________________________________|
SPECIAL SENSES SYSTEM | |
| |
None | |
_____________________________________________________________________________________________________________________|
URINARY SYSTEM | |
| |
__________________________________________________________________________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +|
Casts Protein | 2 3 |
Congestion | |
Glomerulosclerosis | 2 3 |
Hydronephrosis | 2 |
Inflammation, Acute | |
Inflammation, Chronic | 2 |
Inflammation, Chronic Active | 2 |
Cortex, Mineralization | 1 1 1 1 |
Papilla, Mineralization | 1 1 |
Papilla, Necrosis | |
Renal Tubule, Casts Protein | |
Renal Tubule, Regeneration | 1 2 2 |
__________________________________________________________________________|
Urinary Bladder | + + + + + + + + + + + + + + + + + + A + + + + M +|
Calculus Micro Observation Only | X |
Inflammation, Acute | 1 |
Necrosis | |
_____________________________________________________________________________________________________________________|
Page 46
NTP Experiment-Test: 05030-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROBENECID Date: 04/29/97
Route: GAVAGE Time: 15:49:50
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 5| 3| 7| 6| 6| 5| 3| 7| 7| 6| 6| 6| 7| 7| 7| 5| 5| 0| 0| 7| 6| 7| |
DAY ON TEST | 3| 3| 3| 8| 5| 3| 8| 2| 0| 0| 3| 3| 4| 3| 1| 3| 3| 2| 6| 6| 2| 3| 3| 1| 3| |
| 1| 1| 1| 9| 5| 1| 6| 6| 9| 6| 1| 1| 0| 5| 1| 1| 1| 7| 8| 8| 0| 1| 1| 1| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
.4 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Esophagus | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Gallbladder | + + + M M + A + + + + + + + + + + A + M M A + + +| 40 |
__________________________________________________________________________|____________|
Intestine Large | + + + + A + + + + + + + + + + + + + + + + A + + +| 47 |
__________________________________________________________________________|____________|
Intestine Large, Cecum | + + + + A + A + + A + + + + + + + A + M + A + + +| 43 |
__________________________________________________________________________|____________|
Intestine Large, Colon | + + + + A + + + + + + + + + + + + + + + + A + + +| 47 |
__________________________________________________________________________|____________|
Intestine Large, Rectum | + + + + A + A + M A + + + + + + + A + M + A + + +| 40 |
Inflammation, Acute | | 1 4.0|
Necrosis | | 1 3.0|
__________________________________________________________________________|____________|
Intestine Small | + + + + A + + + A A + + + + + + + A + + + + + + +| 45 |
__________________________________________________________________________|____________|
Intestine Small, Duodenum | + + + + A + + + A A + + + + + + + A + M + A + + +| 42 |
__________________________________________________________________________|____________|
Intestine Small, Ileum | + + + + A + A + A A + + + + + + + A + + + + + + +| 43 |
__________________________________________________________________________|____________|
Intestine Small, Jejunum | + + + M A + A + A A + + + + M + + A + M + A M + +| 39 |
__________________________________________________________________________|____________|
Liver | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | 2 | 1 2.0|
Clear Cell Focus | | 2 |
Cyst | | 1 |
Fatty Change, Focal | 1 2| 2 1.5|
Hematopoietic Cell Proliferation | | 1 2.0|
Hemorrhage | 2 | 1 2.0|
Mineralization | 2 1 | 3 1.3|
Necrosis | 2 2 2 3 2 2 2 2 2 2 | 14 2.3|
Pigmentation | 1 | 2 1.0|
__________________________________________________________________________|____________|
Mesentery | + | 1 |
__________________________________________________________________________|____________|
Pancreas | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Salivary Glands | + + + + + + + + + + + + + + + + + + + + + + + + +| 49 |
__________________________________________________________________________|____________|
Stomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
__________________________________________________________________________|____________|
Stomach, Forestomach | + + + + + + + + + + + + + + + + + + + + + + + + +| 48 |
Acanthosis, Focal | 4 | 1 4.0|
Acanthosis | 3 3 3 2 3 2 | 7 2.4|
Hyperkeratosis | 2 2 3 2 2 2 3 2 | 10 2.1|
Inflammation, Chronic Active | 2 2 | 2 2.0|
Necrosis | 2 2 2 3 | 4 2.3|
__________________________________________________________________________|____________|
Stomach, Glandular | + + + + A + + + A A + + + + + + + + + + + + + + +| 45 |
Hyperplasia | | 1 1.0|
Necrosis | 1 | 1 1.0|
_____________________________________________________________________________________________________________________| |
CARDIOVASCULAR SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Heart | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Mineralization | 1 | 2 1.5|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 47
NTP Experiment-Test: 05030-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROBENECID Date: 04/29/97
Route: GAVAGE Time: 15:49:50
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 5| 3| 7| 6| 6| 5| 3| 7| 7| 6| 6| 6| 7| 7| 7| 5| 5| 0| 0| 7| 6| 7| |
DAY ON TEST | 3| 3| 3| 8| 5| 3| 8| 2| 0| 0| 3| 3| 4| 3| 1| 3| 3| 2| 6| 6| 2| 3| 3| 1| 3| |
| 1| 1| 1| 9| 5| 1| 6| 6| 9| 6| 1| 1| 0| 5| 1| 1| 1| 7| 8| 8| 0| 1| 1| 1| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
.4 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM - cont | | |
| | |
_____________________________________________________________________________________________________________________| |
ENDOCRINE SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Adrenal Gland | + + + + + + M + + + + + + + + + + + + + + + + + +| 49 |
Capsule, Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 | 30 1.9|
__________________________________________________________________________|____________|
Adrenal Gland, Cortex | + + + + + + M + + + + + + + + + + + + + + + + + +| 49 |
Accessory Adrenal Cortical Nodule | | 1 |
Hyperplasia | 2 2 2 2 2 2 2 2 2 2 2 1| 28 1.9|
Hypertrophy | | 1 1.0|
__________________________________________________________________________|____________|
Adrenal Gland, Medulla | + + + + + + M + + + + M + + + + + + M + + + + M +| 46 |
Hyperplasia | 1 | 6 1.2|
__________________________________________________________________________|____________|
Islets, Pancreatic | + + + + + + M + + + + + + + + + + + + + + + + + +| 49 |
Hyperplasia | | 2 1.5|
__________________________________________________________________________|____________|
Parathyroid Gland | + + + + M M M + + M M + + M M + M + + + M + M M +| 28 |
Cyst | X| 1 |
Hyperplasia | | 1 2.0|
__________________________________________________________________________|____________|
Pituitary Gland | + + + + + + + M + + + M M + + + + + + M + + + + +| 44 |
Pars Distalis, Hyperplasia | 2 | 1 2.0|
__________________________________________________________________________|____________|
Thyroid Gland | + + + + + + M + + + + + + + + + + + + + + + + + +| 47 |
Cyst | X| 1 |
_____________________________________________________________________________________________________________________| |
GENERAL BODY SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
GENITAL SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Epididymis | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Preputial Gland | + + + + + + + + + + + + + + | 21 |
Dilatation | 3 2 3 3 3 | 8 2.9|
Inflammation, Acute | | 2 2.5|
Inflammation, Chronic Active | 3 2 2 2 2 | 5 2.2|
Necrosis | 3 2 | 4 2.3|
__________________________________________________________________________|____________|
Prostate | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Acute | 2 2 | 4 2.3|
__________________________________________________________________________|____________|
Seminal Vesicle | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Inflammation, Acute | 3 | 2 2.0|
__________________________________________________________________________|____________|
Testes | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Interstitial Cell, Hyperplasia | | 1 2.0|
Seminiferous Tubule, Atrophy | 2 2 | 2 2.0|
Seminiferous Tubule, Mineralization | 1 1 | 2 1.0|
_____________________________________________________________________________________________________________________| |
HEMATOPOIETIC SYSTEM | | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 48
NTP Experiment-Test: 05030-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROBENECID Date: 04/29/97
Route: GAVAGE Time: 15:49:50
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 5| 3| 7| 6| 6| 5| 3| 7| 7| 6| 6| 6| 7| 7| 7| 5| 5| 0| 0| 7| 6| 7| |
DAY ON TEST | 3| 3| 3| 8| 5| 3| 8| 2| 0| 0| 3| 3| 4| 3| 1| 3| 3| 2| 6| 6| 2| 3| 3| 1| 3| |
| 1| 1| 1| 9| 5| 1| 6| 6| 9| 6| 1| 1| 0| 5| 1| 1| 1| 7| 8| 8| 0| 1| 1| 1| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
.4 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - cont | | |
| | |
| | |
__________________________________________________________________________|____________|
Bone Marrow | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Angiectasis | | 1 1.0|
__________________________________________________________________________|____________|
Lymph Node | M + + + + + + M M + + + + + + + + + + + + + + + +| 42 |
Axillary, Infiltration Cellular, | | |
Plasma Cell | | 1 3.0|
Lumbar, Infiltration Cellular, | | |
Plasma Cell | 2 | 2 2.5|
Lumbar, Inflammation, Acute | | 1 2.0|
Mandibular, Necrosis | 2 | 1 2.0|
Mediastinal, Angiectasis | 2 | 1 2.0|
Mediastinal, Hematopoietic Cell | | |
Proliferation | 3 | 1 3.0|
Renal, Infiltration Cellular, Plasma | | |
Cell | 2 1 | 3 1.7|
__________________________________________________________________________|____________|
Lymph Node, Mesenteric | M + + M + + + M M M + M + + + + + + + + + + + + +| 38 |
Angiectasis | 2 2 2 1 3 3 3| 14 2.2|
Hematopoietic Cell Proliferation | 2 2 2 2 | 9 2.0|
Necrosis | 2 | 1 2.0|
__________________________________________________________________________|____________|
Spleen | + + + + + + + + + + + + + + + + + M + + + A + + +| 48 |
Angiectasis | | 2 1.0|
Atrophy | | 1 3.0|
Depletion Lymphoid | 2 | 1 2.0|
Hematopoietic Cell Proliferation | 2 2 2 2 2 2 2 3 2 3 2 3 2 2 | 29 2.3|
Necrosis | | 1 1.0|
__________________________________________________________________________|____________|
Thymus | + + + + M + M M M M + + + M + + + + + + M + M + M| 36 |
Atrophy | 3 | 1 3.0|
Depletion Lymphoid | 2 | 2 2.0|
_____________________________________________________________________________________________________________________| |
INTEGUMENTARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Mammary Gland | M M M + M M M M M M + M M M M M M M M M M M M M M| 4 |
__________________________________________________________________________|____________|
Skin | + + + + + + M + + + + + + + + + + + + + + + + + +| 48 |
Prepuce, Hemorrhage | 2 | 1 2.0|
Prepuce, Inflammation, Acute | 1 | 1 1.0|
Prepuce, Necrosis | 3 | 2 3.5|
Subcutaneous Tissue, Mineralization | 1 | 1 1.0|
Subcutaneous Tissue, Necrosis | | 1 2.0|
_____________________________________________________________________________________________________________________| |
MUSCULOSKELETAL SYSTEM | | |
| | |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 49
NTP Experiment-Test: 05030-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROBENECID Date: 04/29/97
Route: GAVAGE Time: 15:49:50
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 5| 3| 7| 6| 6| 5| 3| 7| 7| 6| 6| 6| 7| 7| 7| 5| 5| 0| 0| 7| 6| 7| |
DAY ON TEST | 3| 3| 3| 8| 5| 3| 8| 2| 0| 0| 3| 3| 4| 3| 1| 3| 3| 2| 6| 6| 2| 3| 3| 1| 3| |
| 1| 1| 1| 9| 5| 1| 6| 6| 9| 6| 1| 1| 0| 5| 1| 1| 1| 7| 8| 8| 0| 1| 1| 1| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
.4 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM - cont | | |
| | |
__________________________________________________________________________|____________|
Bone | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Tarsal, Hyperostosis | 2 3 4 2 2 4 2 3 4 3 2 3 3 3 3 3 2 3 | 36 2.9|
__________________________________________________________________________|____________|
Skeletal Muscle | + | 1 |
_____________________________________________________________________________________________________________________| |
NERVOUS SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Brain | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
__________________________________________________________________________|____________|
Spinal Cord | + + | 2 |
_____________________________________________________________________________________________________________________| |
RESPIRATORY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Lung | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Bacterium | 1 | 1 1.0|
Congestion | 2 | 2 2.0|
Hemorrhage | 1 | 4 1.5|
Infiltration Cellular, Histiocyte | | 2 2.5|
Inflammation, Acute | | 2 2.5|
Necrosis | 2 | 1 2.0|
Pigmentation | 1 | 1 1.0|
__________________________________________________________________________|____________|
Nose | M + + + + + M + + + + + M + + + M + + + + + + + +| 43 |
__________________________________________________________________________|____________|
Trachea | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
_____________________________________________________________________________________________________________________| |
SPECIAL SENSES SYSTEM | | |
| | |
None | | |
_____________________________________________________________________________________________________________________| |
URINARY SYSTEM | | |
| | |
__________________________________________________________________________|____________|
Kidney | + + + + + + + + + + + + + + + + + + + + + + + + +| 50 |
Casts Protein | 1 3 | 4 2.3|
Congestion | 2 | 1 2.0|
Glomerulosclerosis | 2 2 | 4 2.3|
Hydronephrosis | | 1 2.0|
Inflammation, Acute | 3 | 1 3.0|
Inflammation, Chronic | | 1 2.0|
Inflammation, Chronic Active | | 1 2.0|
Cortex, Mineralization | 1 2 1 1 1| 9 1.1|
Papilla, Mineralization | 2 | 3 1.3|
Papilla, Necrosis | 3 | 1 3.0|
Renal Tubule, Casts Protein | 2 | 1 2.0|
Renal Tubule, Regeneration | 1 | 4 1.5|
__________________________________________________________________________|____________|
Urinary Bladder | + + + + A + + + + + + + + + + + + + + + + + + + +| 47 |
Calculus Micro Observation Only | X | 2 |
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 50
NTP Experiment-Test: 05030-02 NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL Report: PEIRPT09
Study Type: CHRONIC PROBENECID Date: 04/29/97
Route: GAVAGE Time: 15:49:50
__________________________________________________________________________________________________________________________________
| 7| 7| 7| 5| 3| 7| 6| 6| 5| 3| 7| 7| 6| 6| 6| 7| 7| 7| 5| 5| 0| 0| 7| 6| 7| |
DAY ON TEST | 3| 3| 3| 8| 5| 3| 8| 2| 0| 0| 3| 3| 4| 3| 1| 3| 3| 2| 6| 6| 2| 3| 3| 1| 3| |
| 1| 1| 1| 9| 5| 1| 6| 6| 9| 6| 1| 1| 0| 5| 1| 1| 1| 7| 8| 8| 0| 1| 1| 1| 1| T (*) |
_____________________________________________________________________________________________________________________| |
| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| O |
B6C3F1 MICE MALE | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| T |
ANIMAL ID | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| A |
.4 G/KG | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| L |
HM | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| |
__________________________________________________________________________________________________________________________________
URINARY SYSTEM - cont | | |
| | |
Inflammation, Acute | 2 3 | 3 2.0|
Necrosis | 2 | 1 2.0|
__________________________________________________________________________________________________________________________________
* : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade
+ : Tissue examined microscopically M : Missing tissue 1-4 : Lesion qualified as:
X : Lesion present but not qualified A : Autolysis precludes examination 1) Minimal 3) Moderate
I : Insufficient tissue BLANK : Not examined 2) Mild 4) Marked
Page 51
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