National Toxicology Program

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TR 395 Mouse Pathology Tables

NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11 
LAB: Mason                                                     DATE: 09/04/94   
EXP: 05030                       PROBENECID                    TIME: 15:19:33   
TEST: 02              CAGES FROM 0000 TO LAST CAGE             PAGE:   1        
TEST TYPE: CHRONIC          ROUTE: GAVAGE                      NTP C#: 56097    
CONT: N01CP9561903                                             CAS: 000057669   
PATHOLOGIST: K. MURTHY                       S. EUSTIS                          
--------------------------------------------------------------------------------
                                                                                
                                                                                
                                                                                


REASONS FOR REMOVAL:                                                            
                                                                                
ALL                                                                             
                                                                                
                                                                                
REMOVAL DATE RANGE:                                                             


ALL                                                                             
                                                                                
TREATMENT GROUPS:                                                               
                                                                                
INCLUDE ALL                                                                     

NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11
LAB: Mason                                                     DATE: 09/04/94  
EXP: 05030                       PROBENECID                    TIME: 15:19:33  
TEST: 02              CAGES FROM 0000 TO LAST CAGE                             
TEST TYPE: CHRONIC          ROUTE: GAVAGE                      NTP C#: 56097   
CONT: N01CP9561903                                             CAS: 000057669  
PATHOLOGIST: K. MURTHY                       S. EUSTIS                         

                                    PROBENECID


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 731 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = VEHICLE                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 12     CENSORED DEATHS 0    TERMINAL 38        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      3     310   390   410   522   541   576   582   606   614                 |
 |      680   682                                                                 |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = .1G/KG                                   |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 25     CENSORED DEATHS 2    TERMINAL 23        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      143   208   239   305   390   416   426   431   443   452                 |
 |      463   492   515   561   589   635   645   645   645   646                 |
 |      659   683   707   717   725                                               |
 |  CENSORED DEATHS                                                               |
 |      3     3                                                                   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = .4G/KG                                   |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 26     CENSORED DEATHS 0    TERMINAL 24        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      20    31    304   306   355   408   438   509   515   568                 |
 |      568   589   611   611   620   626   634   635   640   646                 |
 |      667   686   717   722   725   727                                         |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================

                                    PROBENECID


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE MICE
                       FIRST TERMINAL SACRIFICE AT 731 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   731 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |VEHICLE    |    98.0  98.0  98.0  96.0  92.0  92.0  88.0  84.0  80.0  76.0      |
 |           |                                                                    |
 |           |                                                                    |
 |.1G/KG     |   100.0  97.9  93.8  91.7  87.5  77.1  72.9  68.8  56.3  47.9      |
 |           |                                                                    |
 |           |                                                                    |
 |.4G/KG     |    96.0  96.0  96.0  90.0  88.0  86.0  82.0  76.0  60.0  48.0      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                    DOSE                        |
 |                                                                                |
 |                                VEHICLE          .1G/KG           .4G/KG        |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       76.0%            47.9%            48.0%         |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=0.050          P=0.009          P=0.011       |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       493.0            511.2            533.8         |
 |NATURAL DEATHS (C)      |       (55.5)           (33.3)           (38.0)        |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       673.9            592.0            628.4         |
 |(STANDARD ERROR)        |       (19.4)           (28.3)           (24.1)        |
 |                        |                                                       |
 ==================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                                    PROBENECID


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 730 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = VEHICLE                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 49     UNCENSORED DEATHS 17     CENSORED DEATHS 0    TERMINAL 32        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      13    539   580   596   603   612   612   648   655   660                 |
 |      687   687   704   709   709   721   722                                   |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = .1G/KG                                   |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 49     UNCENSORED DEATHS 16     CENSORED DEATHS 1    TERMINAL 32        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      337   347   488   536   547   550   570   595   606   627                 |
 |      644   646   674   686   694   717                                         |
 |  CENSORED DEATHS                                                               |
 |      108                                                                       |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = .4G/KG                                   |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 50     UNCENSORED DEATHS 18     CENSORED DEATHS 0    TERMINAL 32        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      303   343   343   408   422   475   486   514   527   567                 |
 |      583   585   586   605   643   672   716   717                             |
 |  CENSORED DEATHS                                                               |
 |      NONE                                                                      |
 |                                                                                |
 ==================================================================================

                                    PROBENECID


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE MICE
                       FIRST TERMINAL SACRIFICE AT 730 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   730 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |VEHICLE    |    98.0  98.0  98.0  98.0  98.0  98.0  95.9  89.8  79.6  65.3      |
 |           |                                                                    |
 |           |                                                                    |
 |.1G/KG     |   100.0 100.0 100.0  95.8  95.8  95.8  91.7  83.3  75.0  66.7      |
 |           |                                                                    |
 |           |                                                                    |
 |.4G/KG     |   100.0 100.0 100.0  94.0  90.0  88.0  82.0  72.0  70.0  64.0      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                    DOSE                        |
 |                                                                                |
 |                                VEHICLE          .1G/KG           .4G/KG        |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       65.3%            66.7%            64.0%         |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=0.679          P=1.000          P=0.759       |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       615.1            579.0            527.5         |
 |NATURAL DEATHS (C)      |       (39.9)           (28.1)           (29.8)        |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       690.1            668.0            657.1         |
 |(STANDARD ERROR)        |       (15.7)           (17.9)           (17.4)        |
 |                        |                                                       |
 ==================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                                                             PROBENECID
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        VEHICLE          = 1
                                                        .1G/KG           = 2
                                                        .4G/KG           = 3

------------------------------------------------------ SPECIES=MICE SEX=MALE -------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  100 + 11 3                   2
      |  1 3  3                2         2                1
      |       3                          2     2        2 1           1  1
      |                                                 2       3     2  1                 1
P  90 +                                                         3     2  32                1  1
E     |                                                                  322 3                1    1
R     |                                                                    223          33         11   1
C     |                                                                     2 2 2        3        3     11
E  80 +                                                                         2 2                      1          1
N     |                                                                           2   2           3   3
T     |                                                                               2  2            3  3          1       1
      |                                                                                  2       2       33
S  70 +                                                                                          2    2   332
U     |                                                                                                    32 2
R     |                                                                                                     33
V     |                                                                                                      33
I  60 +                                                                                                       3   3
V     |                                                                                                       2  23 2
A     |                                                                                                             2  2 33
L     |                                                                                                                2 2
   50 +                                                                                                                  22
      |                                                                                                                   2 2
      |
      |
   40 +
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 17 obs hidden.

                                                             PROBENECID
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        VEHICLE          = 1
                                                        .1G/KG           = 2
                                                        .4G/KG           = 3

----------------------------------------------------- SPECIES=MICE SEX=FEMALE ------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  100 + 1 1                                             3     2
      |
      |   1                                             3     22                             1
      |                                                        2                     2       1     1
   95 +
      |                                                       3          3           2       2     1   1
      |                                                                  3 3
      |                                                                                      2 2       11
P  90 +                                                                    3       3                    11
E     |
R     |                                                                            3 3         2  2
C     |                                                                              3   3               1    1
E  85 +                                                                                           2   2
N     |                                                                                  3  3         2 2     11
T     |                                                                                     3    3
      |                                                                                                 2  2   1 1
S  80 +                                                                                          3  3            1   1
U     |                                                                                                    2 2
R     |                                                                                                      22
V     |
I  75 +                                                                                                       2    2 1 1
V     |                                                                                             3   3              11
A     |                                                                                                 3    3     22
L     |                                                                                                             2 2
   70 +                                                                                                      3    3     11
      |                                                                                                               2  2
      |                                                                                                           3      11
      |                                                                                                                  2  2
   65 +                                                                                                                   1 1
      |                                                                                                                  3  3
      |
      |
   60 +
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 4 obs hidden.

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