TR 395 Rat Pathology Tables
INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
PROBENECID
NTP Experiment-Test: 05030-01 Report: PEIRPT03
Study Type: CHRONIC Date: 09/04/94
Route: GAVAGE Time: 13:40:31
Facility: TSI Mason Research
Chemical CAS #: 57-66-9
Lock Date: None
Cage Range: All
Reasons For Removal: All
Removal Date Range: All
Treatment Groups: Include All
a Number of animals examined microscopically at site and number of animals with lesion
Page 1
NTP Experiment-Test: 05030-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC PROBENECID Date: 09/04/94
Route: GAVAGE Time: 13:40:31
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE .1G/KG .4G/KG
FEMALE LF HF
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50
Early Deaths
Moribund 25 15 20
Dead 1 10
Gavage Death 1
Survivors
Terminal Sacrifice 23 35 19
Moribund 1
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (48) (49) (48)
Inflammation, Chronic Active 1 (2%)
Intestine Large, Cecum (50) (9) (44)
Parasite 1 (2%)
Intestine Large, Colon (49) (9) (48)
Parasite 2 (4%) 9 (19%)
Intestine Large, Rectum (48) (8) (45)
Parasite 1 (2%) 1 (13%)
Intestine Small, Ileum (49) (10) (44)
Lymphoid Nodule, Hyperplasia 2 (4%) 1 (2%)
Lymphoid Tissue, Hyperplasia 1 (10%)
Intestine Small, Jejunum (48) (11) (44)
Lymphoid Nodule, Hyperplasia 1 (2%) 1 (9%) 1 (2%)
Liver (50) (30) (50)
Angiectasis 2 (4%) 1 (3%)
Basophilic Focus 35 (70%) 20 (67%) 27 (54%)
Clear Cell Focus 1 (3%) 1 (2%)
Congestion 1 (2%)
Cyst 1 (2%)
Fatty Change, Diffuse 8 (16%) 2 (7%) 1 (2%)
Fatty Change, Focal 9 (18%) 7 (23%) 3 (6%)
Focal Cellular Change 1 (2%)
Hepatodiaphragmatic Nodule 4 (8%) 7 (23%) 5 (10%)
Mixed Cell Focus 5 (10%) 2 (7%) 5 (10%)
Necrosis 1 (2%) 2 (4%)
Pigmentation 2 (4%) 1 (3%)
Regeneration, Focal 1 (2%) 2 (4%)
Bile Duct, Hyperplasia 12 (24%) 7 (23%) 7 (14%)
Mesentery (6) (2) (6)
Artery, Pigmentation 1 (17%)
Artery, Thrombosis 1 (17%)
Fat, Hemorrhage 1 (17%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 2
NTP Experiment-Test: 05030-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC PROBENECID Date: 09/04/94
Route: GAVAGE Time: 13:40:31
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE .1G/KG .4G/KG
FEMALE LF HF
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Fat, Inflammation, Chronic Active 1 (17%)
Fat, Mineralization 1 (17%) 1 (17%)
Fat, Necrosis 4 (67%) 2 (100%) 4 (67%)
Fat, Pigmentation 1 (17%)
Pancreas (50) (14) (50)
Acinus, Atrophy 1 (2%) 1 (2%)
Acinus, Hyperplasia 2 (4%) 1 (2%)
Artery, Pigmentation 1 (2%)
Salivary Glands (50) (10) (48)
Acinus, Hypertrophy 2 (4%)
Acinus, Inflammation, Chronic Active 1 (2%) 1 (2%)
Acinus, Necrosis 2 (4%)
Duct, Inflammation, Acute 1 (10%)
Duct, Inflammation, Chronic Active 5 (10%) 1 (2%)
Duct, Metaplasia, Squamous 18 (36%) 2 (20%) 13 (27%)
Duct, Mineralization 1 (2%)
Stomach, Forestomach (49) (9) (49)
Acanthosis 2 (4%) 1 (2%)
Hemorrhage 1 (2%)
Hyperkeratosis 2 (4%) 1 (11%)
Inflammation, Chronic Active 1 (2%)
Necrosis 2 (4%)
Stomach, Glandular (50) (9) (47)
Hyperplasia 1 (11%)
Mineralization 1 (2%)
Necrosis 1 (2%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (1)
Artery, Inflammation, Chronic Active 1 (100%)
Heart (50) (9) (50)
Cardiomyopathy 32 (64%) 3 (33%) 31 (62%)
Mineralization 1 (11%) 1 (2%)
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland, Cortex (50) (13) (49)
Congestion 1 (2%)
Hemorrhage 1 (2%)
Vacuolization Cytoplasmic 1 (2%) 2 (4%)
Adrenal Gland, Medulla (48) (13) (45)
Hyperplasia 5 (10%) 1 (8%) 6 (13%)
Islets, Pancreatic (50) (11) (50)
Hyperplasia 1 (2%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 3
NTP Experiment-Test: 05030-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC PROBENECID Date: 09/04/94
Route: GAVAGE Time: 13:40:31
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE .1G/KG .4G/KG
FEMALE LF HF
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM - CONT
Pituitary Gland (50) (50) (50)
Pars Distalis, Angiectasis 24 (48%) 24 (48%) 15 (30%)
Pars Distalis, Cyst 7 (14%) 3 (6%) 4 (8%)
Pars Distalis, Hyperplasia 15 (30%) 13 (26%) 11 (22%)
Pars Intermedia, Angiectasis 1 (2%)
Pars Intermedia, Hyperplasia 1 (2%) 1 (2%)
Pars Nervosa, Cyst 1 (2%)
Thyroid Gland (49) (50) (47)
Mineralization 1 (2%)
C-Cell, Hyperplasia 8 (16%) 13 (26%) 4 (9%)
Follicular Cell, Hyperplasia 2 (4%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
Tissue NOS (1)
Abscess 1 (100%)
Mineralization 1 (100%)
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Clitoral Gland (36) (16) (45)
Hyperplasia 1 (6%)
Inflammation, Acute 3 (19%)
Inflammation, Chronic Active 1 (2%)
Necrosis 1 (6%) 1 (2%)
Ovary (50) (16) (50)
Cyst 2 (4%) 1 (6%) 4 (8%)
Pigmentation 1 (2%)
Uterus (50) (16) (49)
Cyst 1 (2%)
Decidual Reaction 1 (2%)
Hemorrhage 1 (2%)
Bilateral, Abscess 1 (2%)
Endometrium, Hyperplasia, Adenomatous 1 (2%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Bone Marrow (50) (8) (50)
Hypoplasia 1 (2%)
Lymph Node (49) (21) (50)
Lumbar, Infiltration Cellular, Plasma Cell 1 (5%)
Mandibular, Hematopoietic Cell Proliferation 1 (2%)
Mandibular, Infiltration Cellular, Plasma
Cell 1 (5%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 4
NTP Experiment-Test: 05030-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC PROBENECID Date: 09/04/94
Route: GAVAGE Time: 13:40:31
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE .1G/KG .4G/KG
FEMALE LF HF
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Mediastinal, Angiectasis 2 (4%)
Mediastinal, Infiltration Cellular, Plasma
Cell 1 (2%) 1 (5%)
Mediastinal, Infiltration Cellular,
Histiocyte 3 (6%) 3 (6%)
Pancreatic, Depletion Lymphoid 1 (2%)
Pancreatic, Hematopoietic Cell Proliferation 1 (2%)
Pancreatic, Infiltration Cellular, Histiocyte 2 (4%) 1 (5%) 2 (4%)
Renal, Angiectasis 3 (6%)
Renal, Infiltration Cellular, Histiocyte 4 (8%) 2 (10%) 2 (4%)
Lymph Node, Mesenteric (49) (20) (50)
Angiectasis 2 (4%) 2 (10%) 1 (2%)
Depletion Lymphoid 1 (2%) 1 (5%) 1 (2%)
Infiltration Cellular, Mast Cell 1 (2%)
Infiltration Cellular, Histiocyte 1 (2%) 7 (35%) 7 (14%)
Spleen (50) (23) (50)
Angiectasis 1 (4%)
Depletion Lymphoid 3 (6%) 1 (4%) 5 (10%)
Fibrosis 1 (2%)
Hematopoietic Cell Proliferation 38 (76%) 6 (26%) 23 (46%)
Hemorrhage 2 (4%) 1 (4%) 1 (2%)
Infiltration Cellular, Histiocyte 9 (18%) 2 (9%) 15 (30%)
Necrosis 2 (4%) 1 (4%) 1 (2%)
Pigmentation 4 (17%)
Thymus (49) (10) (46)
Cyst 1 (2%)
Depletion Lymphoid 2 (4%) 1 (10%) 1 (2%)
Hemorrhage 2 (4%)
Necrosis 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (47) (28) (36)
Galactocele 36 (77%) 13 (46%) 6 (17%)
Acinus, Hyperplasia 1 (2%) 1 (4%) 1 (3%)
Skin (50) (12) (49)
Acanthosis 1 (8%)
Cyst Epithelial Inclusion 1 (2%)
Hyperkeratosis 1 (8%) 1 (2%)
Necrosis 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 5
NTP Experiment-Test: 05030-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC PROBENECID Date: 09/04/94
Route: GAVAGE Time: 13:40:31
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE .1G/KG .4G/KG
FEMALE LF HF
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
Skeletal Muscle (1)
Artery, Pigmentation 1 (100%)
Artery, Thrombosis 1 (100%)
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (10) (50)
Hemorrhage 1 (2%)
Inflammation, Acute 1 (10%)
Brain Stem, Hemorrhage 1 (2%)
Cerebrum, Hemorrhage 1 (2%)
Cerebrum, Necrosis 2 (4%)
Medulla, Hemorrhage 1 (2%)
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (26) (50)
Atelectasis 1 (2%)
Congestion 6 (12%) 10 (38%) 5 (10%)
Edema 8 (16%)
Embolus Tumor 1 (2%)
Fibrosis 1 (2%)
Hemorrhage 2 (4%) 2 (8%) 5 (10%)
Infiltration Cellular, Histiocyte 3 (6%) 6 (12%)
Inflammation, Chronic Active 1 (4%) 3 (6%)
Mineralization 1 (2%)
Alveolar Epithelium, Hyperplasia 2 (4%) 2 (8%) 3 (6%)
Mediastinum, Atypia Cellular 1 (2%)
Nose (49) (9) (50)
Inflammation, Chronic Active 1 (2%) 2 (4%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Eye (11) (13) (6)
Hemorrhage 1 (9%)
Synechia 2 (15%) 1 (17%)
Lens, Cataract 3 (27%) 4 (31%) 3 (50%)
Retina, Atrophy 2 (15%) 1 (17%)
Harderian Gland (6) (5) (7)
Hyperplasia 2 (33%)
Inflammation, Chronic Active 1 (17%)
Pigmentation 2 (33%) 1 (20%) 1 (14%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 6
NTP Experiment-Test: 05030-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC PROBENECID Date: 09/04/94
Route: GAVAGE Time: 13:40:31
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS FEMALE VEHICLE .1G/KG .4G/KG
FEMALE LF HF
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50)
Atrophy 1 (2%)
Cyst 1 (2%)
Hydronephrosis 1 (2%)
Nephropathy 41 (82%) 33 (66%) 30 (60%)
Pigmentation 1 (2%)
Cortex, Inflammation, Acute 1 (2%)
Cortex, Mineralization 4 (8%) 3 (6%) 10 (20%)
Papilla, Mineralization 18 (36%) 10 (20%) 24 (48%)
Papilla, Necrosis 1 (2%)
Pelvis, Mineralization 43 (86%) 30 (60%) 30 (60%)
Renal Tubule, Pigmentation 48 (96%) 47 (94%) 46 (92%)
Urinary Bladder (50) (8) (47)
Hemorrhage 2 (4%) 1 (2%)
Inflammation, Acute 1 (2%)
Mineralization 1 (13%)
Necrosis 1 (2%)
Transitional Epithelium, Hyperplasia 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 7
NTP Experiment-Test: 05030-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC PROBENECID Date: 09/04/94
Route: GAVAGE Time: 13:40:31
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE .1G/KG .4G/KG
MALE LM HM
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY
Animals Initially In Study 50 50 50
Early Deaths
Moribund 10 11 22
Dead 3 4 5
Gavage Death 1 1
Survivors
Terminal Sacrifice 34 32 21
Moribund 2 2 1
Dead 1
Animals Examined Microscopically 50 50 50
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM
Esophagus (48) (12) (48)
Hyperkeratosis 1 (2%)
Necrosis 1 (8%)
Intestine Large, Cecum (48) (7) (48)
Inflammation, Chronic Active 1 (2%)
Lymphoid Nodule, Hyperplasia 1 (2%)
Intestine Large, Colon (47) (8) (48)
Parasite 3 (6%) 6 (13%)
Intestine Large, Rectum (46) (9) (48)
Parasite 1 (11%) 1 (2%)
Intestine Small, Ileum (47) (8) (47)
Lymphoid Nodule, Hyperplasia 1 (2%)
Lymphoid Tissue, Hyperplasia 1 (13%)
Intestine Small, Jejunum (46) (8) (47)
Hemorrhage 1 (13%)
Inflammation, Chronic Active 1 (2%)
Liver (50) (41) (50)
Basophilic Focus 32 (64%) 27 (66%) 34 (68%)
Clear Cell Focus 1 (2%) 11 (27%) 1 (2%)
Congestion 1 (2%) 1 (2%)
Cyst 1 (2%)
Degeneration 1 (2%)
Degeneration, Cystic 1 (2%)
Eosinophilic Focus 1 (2%)
Fatty Change, Diffuse 8 (16%) 4 (10%) 1 (2%)
Fatty Change, Focal 27 (54%) 14 (34%) 14 (28%)
Focal Cellular Change 2 (4%)
Hepatodiaphragmatic Nodule 3 (6%) 6 (15%) 3 (6%)
Mixed Cell Focus 2 (4%) 2 (5%) 1 (2%)
Necrosis 1 (2%) 2 (4%)
Regeneration, Focal 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 8
NTP Experiment-Test: 05030-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC PROBENECID Date: 09/04/94
Route: GAVAGE Time: 13:40:31
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE .1G/KG .4G/KG
MALE LM HM
____________________________________________________________________________________________________________________________________
ALIMENTARY SYSTEM - CONT
Artery, Inflammation, Chronic Active 1 (2%)
Bile Duct, Hyperplasia 35 (70%) 25 (61%) 37 (74%)
Mesentery (9) (4) (5)
Artery, Necrosis, Fibrinoid 2 (22%)
Fat, Inflammation, Chronic Active 2 (40%)
Fat, Necrosis 4 (44%) 1 (25%) 1 (20%)
Fat, Pigmentation 1 (20%)
Pancreas (50) (20) (49)
Acinus, Atrophy 2 (4%) 1 (5%) 1 (2%)
Acinus, Hyperplasia 7 (14%) 2 (10%) 6 (12%)
Artery, Mineralization 1 (5%)
Artery, Necrosis, Fibrinoid 2 (4%) 1 (5%)
Pharynx (1)
Hyperplasia, Pseudoepitheliomatous 1 (100%)
Salivary Glands (49) (16) (49)
Fibrosis 1 (6%)
Hyperplasia 1 (6%)
Acinus, Inflammation, Chronic Active 1 (2%)
Artery, Necrosis, Fibrinoid 1 (2%)
Duct, Inflammation, Acute 1 (6%)
Duct, Inflammation, Chronic Active 3 (6%) 1 (2%)
Duct, Metaplasia 1 (6%) 1 (2%)
Duct, Metaplasia, Squamous 11 (22%) 5 (31%) 10 (20%)
Stomach, Forestomach (50) (12) (50)
Acanthosis 2 (4%) 3 (25%) 6 (12%)
Hyperkeratosis 3 (6%) 3 (25%) 5 (10%)
Hyperplasia, Basal Cell 1 (8%)
Inflammation, Chronic Active 1 (2%) 1 (8%) 1 (2%)
Mineralization 1 (8%)
Necrosis 2 (4%) 1 (8%) 2 (4%)
Artery, Necrosis, Fibrinoid 1 (2%)
Stomach, Glandular (49) (11) (49)
Hyperplasia 1 (2%)
Mineralization 1 (2%)
Necrosis 1 (2%)
Artery, Necrosis, Fibrinoid 1 (2%)
____________________________________________________________________________________________________________________________________
CARDIOVASCULAR SYSTEM
Blood Vessel (1)
Artery, Necrosis, Fibrinoid 1 (100%)
Heart (50) (8) (50)
Cardiomyopathy 37 (74%) 8 (100%) 44 (88%)
Thrombosis 1 (2%)
Artery, Necrosis, Fibrinoid 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 9
NTP Experiment-Test: 05030-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC PROBENECID Date: 09/04/94
Route: GAVAGE Time: 13:40:31
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE .1G/KG .4G/KG
MALE LM HM
____________________________________________________________________________________________________________________________________
ENDOCRINE SYSTEM
Adrenal Gland (49) (50) (50)
Accessory Adrenal Cortical Nodule 1 (2%)
Adrenal Gland, Cortex (49) (50) (50)
Hemorrhage 1 (2%) 1 (2%)
Hyperplasia 3 (6%)
Vacuolization Cytoplasmic 1 (2%)
Adrenal Gland, Medulla (49) (50) (50)
Hyperplasia 9 (18%) 15 (30%) 14 (28%)
Islets, Pancreatic (49) (19) (49)
Hyperplasia 4 (8%) 1 (5%) 1 (2%)
Parathyroid Gland (42) (11) (42)
Hyperplasia 1 (2%)
Pituitary Gland (50) (26) (50)
Pars Distalis, Angiectasis 9 (18%) 11 (42%) 9 (18%)
Pars Distalis, Cyst 1 (4%)
Pars Distalis, Hemorrhage 1 (2%) 1 (2%)
Pars Distalis, Hyperplasia 11 (22%) 6 (23%) 7 (14%)
Pars Distalis, Necrosis 1 (2%)
Pars Distalis, Pigmentation 1 (4%)
Pars Intermedia, Angiectasis 2 (8%)
Pars Intermedia, Hyperplasia 1 (2%)
Thyroid Gland (49) (12) (49)
Hemorrhage 1 (2%)
C-Cell, Hyperplasia 7 (14%) 1 (8%) 10 (20%)
Capsule, Necrosis, Fibrinoid 1 (2%)
____________________________________________________________________________________________________________________________________
GENERAL BODY SYSTEM
None
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM
Epididymis (49) (26) (48)
Fibrosis 1 (2%)
Inflammation, Chronic Active 1 (2%) 1 (2%)
Spermatocele 2 (4%)
Preputial Gland (49) (15) (50)
Cyst 1 (2%)
Inflammation, Chronic Active 2 (4%) 1 (7%) 1 (2%)
Necrosis 7 (14%) 7 (14%)
Prostate (49) (10) (50)
Inflammation, Chronic Active 5 (10%) 2 (20%) 3 (6%)
Artery, Necrosis, Fibrinoid 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 10
NTP Experiment-Test: 05030-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC PROBENECID Date: 09/04/94
Route: GAVAGE Time: 13:40:31
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE .1G/KG .4G/KG
MALE LM HM
____________________________________________________________________________________________________________________________________
GENITAL SYSTEM - CONT
Epithelium, Hyperplasia 2 (4%) 3 (6%)
Seminal Vesicle (49) (30) (50)
Concretion 3 (10%)
Testes (49) (44) (50)
Atrophy 1 (2%)
Congestion 1 (2%)
Interstitial Cell, Hyperplasia 17 (35%) 20 (45%) 26 (52%)
Seminiferous Tubule, Atrophy 37 (76%) 25 (57%) 32 (64%)
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM
Lymph Node (50) (27) (48)
Iliac, Infiltration Cellular, Histiocyte 1 (2%)
Lumbar, Angiectasis 1 (4%)
Lumbar, Hematopoietic Cell Proliferation 1 (2%)
Lumbar, Hemorrhage 2 (4%)
Lumbar, Infiltration Cellular, Histiocyte 1 (4%) 2 (4%)
Lumbar, Pigmentation 1 (4%)
Mandibular, Angiectasis 1 (4%)
Mandibular, Necrosis 1 (2%)
Mediastinal, Angiectasis 1 (2%) 1 (4%) 4 (8%)
Mediastinal, Depletion Lymphoid 1 (2%)
Mediastinal, Infiltration Cellular,
Histiocyte 5 (10%) 2 (7%) 4 (8%)
Mediastinal, Pigmentation 4 (15%)
Pancreatic, Infiltration Cellular, Histiocyte 2 (7%) 1 (2%)
Pancreatic, Pigmentation 6 (22%)
Renal, Angiectasis 2 (4%) 1 (4%) 2 (4%)
Renal, Depletion Lymphoid 1 (2%)
Renal, Hemorrhage 1 (2%)
Renal, Infiltration Cellular, Histiocyte 4 (8%) 2 (7%) 11 (23%)
Renal, Pigmentation 4 (15%)
Lymph Node, Mesenteric (50) (20) (47)
Angiectasis 1 (2%) 2 (10%) 5 (11%)
Depletion Lymphoid 2 (4%)
Hemorrhage 1 (2%)
Infiltration Cellular, Mast Cell 1 (2%)
Infiltration Cellular, Histiocyte 4 (20%) 18 (38%)
Pigmentation 9 (45%)
Renal, Angiectasis 1 (2%)
Spleen (50) (19) (49)
Congestion 1 (5%)
Depletion Lymphoid 1 (2%) 1 (5%) 2 (4%)
Fibrosis 1 (5%) 1 (2%)
Hematopoietic Cell Proliferation 27 (54%) 9 (47%) 38 (78%)
Hemorrhage 1 (5%) 1 (2%)
a Number of animals examined microscopically at site and number of animals with lesion
Page 11
NTP Experiment-Test: 05030-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC PROBENECID Date: 09/04/94
Route: GAVAGE Time: 13:40:31
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE .1G/KG .4G/KG
MALE LM HM
____________________________________________________________________________________________________________________________________
HEMATOPOIETIC SYSTEM - CONT
Infiltration Cellular, Histiocyte 1 (2%) 3 (6%)
Necrosis 2 (4%) 1 (5%)
Pigmentation 1 (2%)
Capsule, Fibrosis 1 (2%)
Capsule, Inflammation, Chronic Active 1 (2%)
Thymus (46) (14) (46)
Atrophy 1 (2%) 1 (2%)
Depletion Lymphoid 1 (2%)
Epithelial Cell, Hyperplasia 2 (4%) 1 (2%)
____________________________________________________________________________________________________________________________________
INTEGUMENTARY SYSTEM
Mammary Gland (26) (9) (27)
Galactocele 7 (27%) 3 (33%) 5 (19%)
Acinus, Hyperplasia 1 (4%)
Skin (49) (20) (50)
Abscess 1 (2%)
Cyst Epithelial Inclusion 2 (4%) 1 (5%) 1 (2%)
Fibrosis 1 (2%)
Hyperkeratosis 4 (8%) 3 (15%) 4 (8%)
Hyperplasia, Basal Cell 1 (5%) 1 (2%)
Inflammation, Acute 1 (2%)
Necrosis 1 (2%) 3 (6%)
Pigmentation 1 (5%)
____________________________________________________________________________________________________________________________________
MUSCULOSKELETAL SYSTEM
None
____________________________________________________________________________________________________________________________________
NERVOUS SYSTEM
Brain (50) (8) (50)
Artery, Necrosis, Fibrinoid 1 (2%)
Brain Stem, Hemorrhage 1 (2%)
Cerebellum, Hemorrhage 1 (13%) 1 (2%)
Cerebellum, Necrosis 1 (13%)
Cerebrum, Hemorrhage 1 (13%) 1 (2%)
____________________________________________________________________________________________________________________________________
a Number of animals examined microscopically at site and number of animals with lesion
Page 12
NTP Experiment-Test: 05030-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC PROBENECID Date: 09/04/94
Route: GAVAGE Time: 13:40:31
____________________________________________________________________________________________________________________________________
FISCHER 344 RATS MALE VEHICLE .1G/KG .4G/KG
MALE LM HM
____________________________________________________________________________________________________________________________________
RESPIRATORY SYSTEM
Lung (50) (18) (50)
Atelectasis 1 (2%)
Bronchiectasis 1 (2%)
Congestion 3 (6%) 4 (22%) 4 (8%)
Edema 1 (2%) 2 (11%) 3 (6%)
Hemorrhage 3 (17%) 6 (12%)
Infiltration Cellular, Histiocyte 4 (8%) 5 (10%)
Inflammation, Acute 1 (6%)
Inflammation, Chronic Active 2 (4%) 1 (2%)
Alveolar Epithelium, Hyperplasia 2 (4%) 3 (17%) 2 (4%)
Artery, Necrosis, Fibrinoid 1 (2%)
Bronchiole, Metaplasia, Squamous 1 (2%)
Nose (49) (9) (49)
Congestion 1 (11%)
Inflammation, Chronic Active 1 (2%) 1 (11%) 7 (14%)
Trachea (50) (18) (50)
Erosion 1 (2%)
____________________________________________________________________________________________________________________________________
SPECIAL SENSES SYSTEM
Ear (1) (3) (3)
Hemorrhage 1 (33%)
Necrosis 1 (33%)
Eye (5) (8) (11)
Hemorrhage 1 (13%)
Synechia 1 (13%) 2 (18%)
Lens, Cataract 1 (20%) 3 (38%) 3 (27%)
Retina, Atrophy 3 (27%)
Retina, Hemorrhage 1 (20%)
Sclera, Pigmentation 1 (9%)
Harderian Gland (4) (7) (4)
Hyperplasia 1 (25%)
____________________________________________________________________________________________________________________________________
URINARY SYSTEM
Kidney (50) (50) (50)
Congestion 2 (4%)
Cyst 1 (2%) 1 (2%)
Hydronephrosis 1 (2%)
Nephropathy 48 (96%) 48 (96%) 47 (94%)
Artery, Inflammation 1 (2%)
Cortex, Mineralization 2 (4%) 9 (18%) 2 (4%)
Papilla, Mineralization 32 (64%) 31 (62%) 35 (70%)
Pelvis, Mineralization 4 (8%) 12 (24%) 13 (26%)
a Number of animals examined microscopically at site and number of animals with lesion
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NTP Experiment-Test: 05030-01 INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a) Report: PEIRPT03
Study Type: CHRONIC PROBENECID Date: 09/04/94
Route: GAVAGE Time: 13:40:31
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FISCHER 344 RATS MALE VEHICLE .1G/KG .4G/KG
MALE LM HM
____________________________________________________________________________________________________________________________________
URINARY SYSTEM - CONT
Pelvis, Transitional Epithelium, Hyperplasia 1 (2%)
Renal Tubule, Degeneration 1 (2%)
Renal Tubule, Hyperplasia 3 (6%)
Renal Tubule, Mineralization 3 (6%)
Renal Tubule, Pigmentation 46 (92%) 46 (92%) 46 (92%)
Urinary Bladder (48) (10) (47)
Calculus Gross Observation 2 (4%) 2 (20%)
Calculus Micro Observation Only 3 (6%) 2 (20%) 1 (2%)
Hemorrhage 1 (10%)
Necrosis 1 (10%)
a Number of animals examined microscopically at site and number of animals with lesion
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