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TR 395 Rat Pathology Tables


                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                             PROBENECID


NTP Experiment-Test: 05030-01                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 09/04/94
Route: GAVAGE                                                                                                     Time: 13:40:33




       Facility:  TSI Mason Research

       Chemical CAS #:  57-66-9

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05030-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             PROBENECID                                        Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 13:40:33  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   VEHICLE      .1G/KG       .4G/KG                                                 
                                                    FEMALE       LF           HF                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Moribund                                          25           15           20                                                  
    Dead                                               1                        10                                                  
    Gavage Death                                                                 1                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                23           35           19                                                  
    Moribund                                           1                                                                            
  Animals Examined Microscopically                    50           50           50                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Liver                                              (50)         (30)         (50)                                                
      Histiocytic Sarcoma                                           1 (3%)       1 (2%)                                             
      Neoplastic Nodule                                             1 (3%)       2 (4%)                                             
      Sarcoma, Metastatic, Uncertain Primary Site      1 (2%)                                                                       
   Mesentery                                          (6)          (2)          (6)                                                 
      Histiocytic Sarcoma                                                        1 (17%)                                            
      Sarcoma, Metastatic, Uncertain Primary Site      1 (17%)                                                                      
      Sarcoma Stromal, Metastatic                                                1 (17%)                                            
   Pancreas                                           (50)         (14)         (50)                                                
      Histiocytic Sarcoma                                                        1 (2%)                                             
   Salivary Glands                                    (50)         (10)         (48)                                                
      Carcinoma, Metastatic, Thyroid Gland             1 (2%)                                                                       
   Stomach, Forestomach                               (49)         (9)          (49)                                                
      Histiocytic Sarcoma                                                        1 (2%)                                             
   Stomach, Glandular                                 (50)         (9)          (47)                                                
      Histiocytic Sarcoma                                                        1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (9)          (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (50)         (13)         (49)                                                
      Adenoma                                          1 (2%)                    1 (2%)                                             
      Carcinoma, Metastatic                            1 (2%)                                                                       
      Histiocytic Sarcoma                                                        1 (2%)                                             
   Adrenal Gland, Medulla                             (48)         (13)         (45)                                                
      Histiocytic Sarcoma                                                        1 (2%)                                             
                                                             Page   2                                                               
NTP Experiment-Test: 05030-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             PROBENECID                                        Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 13:40:33  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   VEHICLE      .1G/KG       .4G/KG                                                 
                                                    FEMALE       LF           HF                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - cont                                                                                                             
      Pheochromocytoma Benign                          1 (2%)       1 (8%)       1 (2%)                                             
      Bilateral, Pheochromocytoma Benign               1 (2%)                                                                       
   Islets, Pancreatic                                 (50)         (11)         (50)                                                
      Adenoma                                                       1 (9%)       2 (4%)                                             
   Pituitary Gland                                    (50)         (50)         (50)                                                
      Pars Distalis, Adenoma                          20 (40%)     25 (50%)     15 (30%)                                            
      Pars Distalis, Adenoma, Multiple                 2 (4%)       1 (2%)       1 (2%)                                             
      Pars Intermedia, Adenoma                                                   1 (2%)                                             
   Thyroid Gland                                      (49)         (50)         (47)                                                
      Bilateral, C-Cell, Carcinoma                                               1 (2%)                                             
      C-Cell, Adenoma                                  9 (18%)      3 (6%)       1 (2%)                                             
      C-Cell, Carcinoma                                3 (6%)       1 (2%)       1 (2%)                                             
      Follicular Cell, Adenoma                         1 (2%)       1 (2%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (36)         (16)         (45)                                                
      Adenoma                                          3 (8%)       7 (44%)      1 (2%)                                             
      Carcinoma                                                     1 (6%)                                                          
   Ovary                                              (50)         (16)         (50)                                                
      Arrhenoblastoma Benign                                                     1 (2%)                                             
      Granulosa Cell Tumor Benign                      2 (4%)       1 (6%)       1 (2%)                                             
      Histiocytic Sarcoma                                           1 (6%)       1 (2%)                                             
   Uterus                                             (50)         (16)         (49)                                                
      Adenoma                                                                    1 (2%)                                             
      Deciduoma NOS                                    1 (2%)                                                                       
      Leiomyosarcoma                                                             1 (2%)                                             
      Polyp Stromal                                    6 (12%)     10 (63%)      9 (18%)                                            
      Sarcoma Stromal                                  1 (2%)                    2 (4%)                                             
      Bilateral, Polyp Stromal                         1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Blood                                              (23)                      (18)                                                
   Bone Marrow                                        (50)         (8)          (50)                                                
   Lymph Node                                         (49)         (21)         (50)                                                
      Mandibular, Carcinoma, Metastatic, Thyroid                                                                                    
          Gland                                        1 (2%)                    1 (2%)                                             
   Lymph Node, Mesenteric                             (49)         (20)         (50)                                                
   Spleen                                             (50)         (23)         (50)                                                
                                                             Page   3                                                               
NTP Experiment-Test: 05030-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             PROBENECID                                        Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 13:40:33  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   VEHICLE      .1G/KG       .4G/KG                                                 
                                                    FEMALE       LF           HF                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - cont                                                                                                         
      Sarcoma                                                                    1 (2%)                                             
   Thymus                                             (49)         (10)         (46)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (47)         (28)         (36)                                                
      Adenocarcinoma                                   3 (6%)       1 (4%)                                                          
      Fibroadenoma                                    14 (30%)     17 (61%)      5 (14%)                                            
      Fibroadenoma, Multiple                          10 (21%)      6 (21%)                                                         
   Skin                                               (50)         (12)         (49)                                                
      Basal Cell Carcinoma                                          1 (8%)                                                          
      Histiocytic Sarcoma                                                        1 (2%)                                             
      Neurofibroma                                     1 (2%)                                                                       
      Sarcoma                                          2 (4%)       1 (8%)                                                          
      Squamous Cell Carcinoma                          1 (2%)                                                                       
      Subcutaneous Tissue, Fibroma                     1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (10)         (50)                                                
      Astrocytoma Benign                                            1 (10%)                                                         
      Cerebrum, Oligodendroglioma Malignant            1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (26)         (50)                                                
      Alveolar/Bronchiolar Adenoma                     2 (4%)       2 (8%)       1 (2%)                                             
      Carcinoma, Metastatic, Thyroid Gland             2 (4%)                    1 (2%)                                             
      Histiocytic Sarcoma                                                        1 (2%)                                             
      Sarcoma, Metastatic, Uncertain Primary Site      1 (2%)                                                                       
   Trachea                                            (50)         (46)         (50)                                                
      Carcinoma, Metastatic, Thyroid Gland             1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   4                                                               
NTP Experiment-Test: 05030-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             PROBENECID                                        Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 13:40:33  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   VEHICLE      .1G/KG       .4G/KG                                                 
                                                    FEMALE       LF           HF                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)                                                
   Urinary Bladder                                    (50)         (8)          (47)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)                                                
      Histiocytic Sarcoma                                           1 (2%)       1 (2%)                                             
      Leukemia Mononuclear                            15 (30%)     17 (34%)     17 (34%)                                            
      Lymphoma Malignant Histiocytic                                             1 (2%)                                             
      Lymphoma Malignant Undifferentiated Cell                                   1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   5                                                               
NTP Experiment-Test: 05030-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             PROBENECID                                        Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 13:40:33  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   VEHICLE      .1G/KG       .4G/KG                                                 
                                                    FEMALE       LF           HF                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            48          46          37                                                   
     Total Primary Neoplasms                          102         100          70                                                   
                                                                                                                                    
   Total Animals with Benign Neoplasms                 41          39          29                                                   
     Total Benign Neoplasms                            75          77          44                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms              26          21          24                                                   
     Total Malignant Neoplasms                         26          23          26                                                   
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              3                       2                                                   
     Total Metastatic Neoplasm                          9                       3                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms               1                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                  1                                                                           
     Total Uncertain Neoplasms                          1                                                                           
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   6                                                               
NTP Experiment-Test: 05030-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             PROBENECID                                        Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 13:40:33  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     VEHICLE      .1G/KG       .4G/KG                                                 
                                                   MALE          LM           HM                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          50           50           50                                                  
  Early Deaths                                                                                                                      
    Moribund                                          10           11           22                                                  
    Dead                                               3            4            5                                                  
    Gavage Death                                                    1            1                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                34           32           21                                                  
    Moribund                                           2            2            1                                                  
    Dead                                               1                                                                            
  Animals Examined Microscopically                    50           50           50                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (47)         (8)          (48)                                                
   Intestine Small, Duodenum                          (48)         (9)          (49)                                                
      Adenocarcinoma                                                             1 (2%)                                             
   Intestine Small, Jejunum                           (46)         (8)          (47)                                                
      Adenocarcinoma                                                1 (13%)                                                         
      Leiomyoma                                                                  1 (2%)                                             
   Liver                                              (50)         (41)         (50)                                                
      Fibrous Histiocytoma, Metastatic, Skin                        1 (2%)                                                          
      Hepatocellular Carcinoma                                      1 (2%)                                                          
      Neoplastic Nodule                                1 (2%)       1 (2%)                                                          
   Mesentery                                          (9)          (4)          (5)                                                 
      Hepatocellular Carcinoma, Metastatic, Liver                   1 (25%)                                                         
   Pancreas                                           (50)         (20)         (49)                                                
      Acinus, Adenoma                                                            1 (2%)                                             
   Salivary Glands                                    (49)         (16)         (49)                                                
   Stomach, Forestomach                               (50)         (12)         (50)                                                
      Squamous Cell Papilloma                                       1 (8%)                                                          
   Stomach, Glandular                                 (49)         (11)         (49)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (50)         (8)          (50)                                                
      Schwannoma Malignant                                                       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   7                                                               
NTP Experiment-Test: 05030-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             PROBENECID                                        Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 13:40:33  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     VEHICLE      .1G/KG       .4G/KG                                                 
                                                   MALE          LM           HM                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (49)         (50)         (50)                                                
      Adenoma                                          2 (4%)                                                                       
   Adrenal Gland, Medulla                             (49)         (50)         (50)                                                
      Pheochromocytoma Malignant                       1 (2%)       1 (2%)                                                          
      Pheochromocytoma Benign                         14 (29%)     16 (32%)      6 (12%)                                            
      Bilateral, Pheochromocytoma Benign               5 (10%)      2 (4%)       2 (4%)                                             
   Islets, Pancreatic                                 (49)         (19)         (49)                                                
      Adenoma                                          2 (4%)       2 (11%)      3 (6%)                                             
      Carcinoma                                                     1 (5%)       1 (2%)                                             
   Pituitary Gland                                    (50)         (26)         (50)                                                
      Pars Distalis, Adenoma                          15 (30%)     12 (46%)     17 (34%)                                            
      Pars Distalis, Adenoma, Multiple                              2 (8%)                                                          
   Thyroid Gland                                      (49)         (12)         (49)                                                
      Carcinoma                                                                  1 (2%)                                             
      C-Cell, Adenoma                                  9 (18%)      3 (25%)     10 (20%)                                            
      C-Cell, Carcinoma                                1 (2%)                                                                       
      Follicular Cell, Adenoma                                                   1 (2%)                                             
      Follicular Cell, Carcinoma                                                 1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (49)         (26)         (48)                                                
   Preputial Gland                                    (49)         (15)         (50)                                                
      Adenoma                                          6 (12%)      2 (13%)      7 (14%)                                            
      Carcinoma                                                     2 (13%)      1 (2%)                                             
      Bilateral, Adenoma                                            1 (7%)       2 (4%)                                             
   Seminal Vesicle                                    (49)         (30)         (50)                                                
   Testes                                             (49)         (44)         (50)                                                
      Bilateral, Interstitial Cell, Adenoma           42 (86%)     33 (75%)     37 (74%)                                            
      Bilateral, Interstitial Tissue, Adenoma                       1 (2%)                                                          
      Interstitial Cell, Adenoma                       3 (6%)       5 (11%)      7 (14%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Blood                                              (31)         (1)          (21)                                                
   Bone Marrow                                        (50)         (8)          (49)                                                
   Lymph Node                                         (50)         (27)         (48)                                                
      Bronchial, Mediastinal, Fibrosarcoma,                                                                                         
          Metastatic, Skin                             1 (2%)                                                                       
                                                             Page   8                                                               
NTP Experiment-Test: 05030-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             PROBENECID                                        Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 13:40:33  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     VEHICLE      .1G/KG       .4G/KG                                                 
                                                   MALE          LM           HM                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - cont                                                                                                         
      Mediastinal, Fibrous Histiocytoma,                                                                                            
          Metastatic, Skin                                          1 (4%)                                                          
   Lymph Node, Mesenteric                             (50)         (20)         (47)                                                
      Mediastinal, Hepatocellular Carcinoma,                                                                                        
          Metastatic, Liver                                         1 (5%)                                                          
   Spleen                                             (50)         (19)         (49)                                                
   Thymus                                             (46)         (14)         (46)                                                
      Fibrosarcoma, Metastatic, Skin                   1 (2%)                                                                       
      Epithelial Cell, Thymoma Benign                  1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (26)         (9)          (27)                                                
      Fibroadenoma                                     3 (12%)      2 (22%)                                                         
   Skin                                               (49)         (20)         (50)                                                
      Basal Cell Adenoma                               1 (2%)       1 (5%)                                                          
      Basal Cell Carcinoma                                          1 (5%)       1 (2%)                                             
      Fibrous Histiocytoma                                          1 (5%)                                                          
      Keratoacanthoma                                  2 (4%)       1 (5%)                                                          
      Squamous Cell Carcinoma                                       1 (5%)                                                          
      Squamous Cell Papilloma                                       1 (5%)       1 (2%)                                             
      Trichoepithelioma                                1 (2%)       1 (5%)                                                          
      Subcutaneous Tissue, Fibroma                     5 (10%)      3 (15%)      3 (6%)                                             
      Subcutaneous Tissue, Fibrosarcoma                2 (4%)       1 (5%)                                                          
      Subcutaneous Tissue, Sarcoma                                  1 (5%)       2 (4%)                                             
      Subcutaneous Tissue, Schwannoma Malignant                     1 (5%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                    (2)          (1)          (3)                                                 
      Fibrosarcoma, Metastatic, Skin                   1 (50%)                                                                      
      Fibrous Histiocytoma, Metastatic, Skin                        1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (50)         (8)          (50)                                                
      Astrocytoma Malignant                                                      1 (2%)                                             
      Granular Cell Tumor Benign                                                 1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   9                                                               
NTP Experiment-Test: 05030-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             PROBENECID                                        Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 13:40:33  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     VEHICLE      .1G/KG       .4G/KG                                                 
                                                   MALE          LM           HM                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (50)         (18)         (50)                                                
      Alveolar/Bronchiolar Adenoma                     3 (6%)       2 (11%)      6 (12%)                                            
      Fibrosarcoma, Metastatic, Skin                   1 (2%)                                                                       
      Fibrous Histiocytoma, Metastatic, Skin                        1 (6%)                                                          
      Hepatocellular Carcinoma, Metastatic, Liver                   1 (6%)                                                          
   Nose                                               (49)         (9)          (49)                                                
      Basosquamous Tumor Benign                        1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Ear                                                (1)          (3)          (3)                                                 
      Fibrosarcoma                                     1 (100%)     1 (33%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (50)         (50)         (50)                                                
      Fibrosarcoma, Metastatic, Skin                   1 (2%)                                                                       
      Renal Tubule, Adenoma                                         1 (2%)                                                          
   Urinary Bladder                                    (48)         (10)         (47)                                                
      Fibrous Histiocytoma, Metastatic, Skin                        1 (10%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(50)        *(50)        *(50)                                                
      Leukemia Mononuclear                             6 (12%)     10 (20%)      7 (14%)                                            
      Lymphoma Malignant Undifferentiated Cell                                   1 (2%)                                             
      Mesothelioma Benign                              1 (2%)                                                                       
      Mesothelioma Malignant                           4 (8%)       2 (4%)       5 (10%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page  10                                                               
NTP Experiment-Test: 05030-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                             PROBENECID                                        Date: 09/04/94  
Route: GAVAGE                                                                                                     Time: 13:40:33  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     VEHICLE      .1G/KG       .4G/KG                                                 
                                                   MALE          LM           HM                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            48          48          48                                                   
     Total Primary Neoplasms                          132         118         128                                                   
                                                                                                                                    
   Total Animals with Benign Neoplasms                 47          46          47                                                   
     Total Benign Neoplasms                           117          93         105                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms              15          23          21                                                   
     Total Malignant Neoplasms                         15          25          23                                                   
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              1           2           1                                                   
     Total Metastatic Neoplasm                          5           8           1                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  11                                                               
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