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TR 395 Rat Pathology Tables

NTP Experiment-Test: 05030-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             PROBENECID                                        Date: 04/29/97
Route: GAVAGE                                                                                                     Time: 15:49:49




       Facility:  TSI Mason Research

       Chemical CAS #:  57-66-9

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All






































                                                              Page   1

NTP Experiment-Test: 05030-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             PROBENECID                                        Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 15:49:49  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 5| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 4| 7| 7| 7| 6| 6|             
                             DAY ON TEST   | 3| 3| 2| 9| 1| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 2| 9| 9| 3| 3| 2| 5| 3|             
                                           | 5| 5| 2| 2| 0| 5| 6| 5| 4| 5| 5| 5| 5| 5| 5| 5| 6| 2| 3| 5| 5| 6| 9| 1| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     FEMALE                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite                             |                1                                                         |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Parasite                             |                                           1                              |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Lymphoid Nodule, Hyperplasia         |             1                                                            |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Lymphoid Nodule, Hyperplasia         |             2                                                            |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          | 2                                3                                       |             
      Basophilic Focus                     | X  X           X  X     X     1     X     X  X  X  X  2     X  X  X  X  X|             
      Cyst                                 |                                                          X               |             
      Fatty Change, Diffuse                |          2              2  2                                             |             
      Fatty Change, Focal                  |             1                          1  1           2           1  1   |             
      Focal Cellular Change                |                                                                          |             
      Hepatodiaphragmatic Nodule           |                   X                                            X         |             
      Mixed Cell Focus                     |                      X        X  X     X                                 |             
      Necrosis                             |                            1                                             |             
      Pigmentation                         |                         2                                2               |             
      Regeneration, Focal                  |                                                                          |             
      Bile Duct, Hyperplasia               |       2                       2     2        2  2                        |             
                                            __________________________________________________________________________|             
   Mesentery                               |          +                                         +     +        +      |             
      Artery, Pigmentation                 |          2                                                               |             
      Artery, Thrombosis                   |          2                                                               |             
      Fat, Inflammation, Chronic Active    |                                                                   2      |             
      Fat, Mineralization                  |                                                                          |             
      Fat, Necrosis                        |          1                                         4                     |             
      Fat, Pigmentation                    |                                                                   2      |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |                                                                          |             
      Acinus, Hyperplasia                  |                   3  2                                                   |             
      Artery, Pigmentation                 |          2                                                               |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Hypertrophy                  |                                                                          |             
      Acinus, Inflammation, Chronic Active |                                                                          |             
      Acinus, Necrosis                     |                                  1                             1         |             
      Duct, Inflammation, Chronic Active   |                      1           2              1              2         |             
      Duct, Metaplasia, Squamous           | 1  1  2              2           2              1           2  2        1|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05030-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             PROBENECID                                        Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 15:49:49  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 5| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 4| 7| 7| 7| 6| 6|             
                             DAY ON TEST   | 3| 3| 2| 9| 1| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 2| 9| 9| 3| 3| 2| 5| 3|             
                                           | 5| 5| 2| 2| 0| 5| 6| 5| 4| 5| 5| 5| 5| 5| 5| 5| 6| 2| 3| 5| 5| 6| 9| 1| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     FEMALE                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |          1                                                               |             
      Hyperkeratosis                       |          2                                                               |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 2        2           3  2  2  2  2        2  2  2  2        2  2  2  2   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Vacuolization Cytoplasmic            |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Hyperplasia                          |                               2  1              2                        |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                            3                                             |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  M  M  +  M  +  M  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           | 2        2     3           2  2     2        2  2     2     3     2     2|             
      Pars Distalis, Cyst                  |                   X                                      X           X   |             
      Pars Distalis, Hyperplasia           | 2        2  2           2                       2  2           2         |             
      Pars Intermedia, Hyperplasia         |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |    1  1                       1                                         1|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                +                                                         |             
      Abscess                              |                2                                                         |             
      Mineralization                       |                2                                                         |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  M  +  +  M  M  +  M  +  +  +  M  +  +  M  +  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                   X                    X                                 |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                   X      |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   | +  +           +  +  +           +  +  +  +  +  +  +        +            |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hypoplasia                           |                         3                                                |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05030-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             PROBENECID                                        Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 15:49:49  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 5| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 4| 7| 7| 7| 6| 6|             
                             DAY ON TEST   | 3| 3| 2| 9| 1| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 2| 9| 9| 3| 3| 2| 5| 3|             
                                           | 5| 5| 2| 2| 0| 5| 6| 5| 4| 5| 5| 5| 5| 5| 5| 5| 6| 2| 3| 5| 5| 6| 9| 1| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     FEMALE                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Mediastinal, Angiectasis             |                                                                          |             
      Mediastinal, Infiltration Cellular,  |                                                                          |             
           Plasma Cell                     |                                                                          |             
      Mediastinal, Infiltration Cellular,  |                                                                          |             
           Histiocyte                      |                                                                   2  2   |             
      Pancreatic, Depletion Lymphoid       |                         2                                                |             
      Pancreatic, Hematopoietic Cell       |                                                                          |             
          Proliferation                    |                         2                                                |             
      Pancreatic, Infiltration Cellular,   |                                                                          |             
           Histiocyte                      |                                           2                              |             
      Renal, Angiectasis                   |                               2           2                              |             
      Renal, Infiltration Cellular,        |                                                                          |             
          Histiocyte                       |                               2           2                       2      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Angiectasis                          |                                                 2  2                     |             
      Depletion Lymphoid                   |                                           2                              |             
      Infiltration Cellular, Histiocyte    |                            2                                             |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Depletion Lymphoid                   |                         2        2                                       |             
      Fibrosis                             |                         2                                                |             
      Hematopoietic Cell Proliferation     | 2  2     2     2  2  2  3  2  2  2  2  2  2     2  2     3  2  2  2     2|             
      Hemorrhage                           |                                           2                          2   |             
      Infiltration Cellular, Histiocyte    |                         2                             2              3   |             
      Necrosis                             |          3                                                               |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Depletion Lymphoid                   |                            2                             3               |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Galactocele                          | X     X     X  X  X     X     X  X  X  X  X  X  X  X  X     X  X  X     X|             
      Acinus, Hyperplasia                  |          2                                                               |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |          +                                                               |             
      Artery, Pigmentation                 |          2                                                               |             
      Artery, Thrombosis                   |          3                                                               |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Brain Stem, Hemorrhage               |                                                             2            |             
      Cerebrum, Necrosis                   |                                                          2               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05030-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             PROBENECID                                        Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 15:49:49  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 5| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7| 7| 5| 4| 7| 7| 7| 6| 6|             
                             DAY ON TEST   | 3| 3| 2| 9| 1| 3| 3| 3| 4| 3| 3| 3| 3| 3| 3| 3| 3| 2| 9| 9| 3| 3| 2| 5| 3|             
                                           | 5| 5| 2| 2| 0| 5| 6| 5| 4| 5| 5| 5| 5| 5| 5| 5| 6| 2| 3| 5| 5| 6| 9| 1| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     FEMALE                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Medulla, Hemorrhage                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Embolus Tumor                        |                                                          X               |             
      Hemorrhage                           |                                                 1                        |             
      Infiltration Cellular, Histiocyte    | 1                                                                        |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Mediastinum, Atypia Cellular         |                   3                                                      |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |             +                                         +                  |             
                                            __________________________________________________________________________|             
   Eye                                     |             +                 +                       +                  |             
      Hemorrhage                           |                                                                          |             
      Lens, Cataract                       |                               2                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                               +           +                              |             
      Hyperplasia                          |                               2                                          |             
      Inflammation, Chronic Active         |                               1                                          |             
      Pigmentation                         |                               2                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |       2                                                                  |             
      Hydronephrosis                       |       2                                                                  |             
      Nephropathy                          | 1  2  2  1     3  1  2  1  2  1  1  1  1  1  1  2  1  2     2  1  1     1|             
      Cortex, Mineralization               |                                                                      1   |             
      Papilla, Mineralization              |          1     2  1     2     1                 1     1  1  1     1  1   |             
      Pelvis, Mineralization               | 1  1  1  1  1  1  1  1  2     1  1  1  1  1  1     1  1  1  1     1  1  1|             
      Renal Tubule, Pigmentation           | 1  1  1  1     1  1  1  2  1  1  1  1  1  1  1  1  1  1  1  1  2  1  1  1|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05030-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             PROBENECID                                        Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 15:49:49  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 6| 6| 7| 7| 7| 6| 5| 7| 6| 6| 6| 5| 7| 7| 7| 6| 5| 7| 7| 6| 7| 3|            |
                             DAY ON TEST   | 3| 3| 7| 5| 3| 3| 3| 0| 6| 4| 3| 6| 7| 5| 7| 3| 3| 2| 2| 2| 3| 3| 4| 2| 5|            |
                                           | 5| 6| 5| 2| 6| 5| 5| 4| 3| 4| 5| 3| 7| 2| 9| 5| 6| 0| 0| 9| 5| 5| 9| 2| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     FEMALE                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Parasite                             |                                  1                                       |      2  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|  48        |
      Parasite                             |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Lymphoid Nodule, Hyperplasia         |                                     3                                    |      2  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|  48        |
      Lymphoid Nodule, Hyperplasia         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                                          |      2  2.5|
      Basophilic Focus                     | X  X  X  X  X  X  X     X  X  X  X     X     X  X  X           X     X  X|     36  1.5|
      Cyst                                 |                                                                          |      1     |
      Fatty Change, Diffuse                |       2                    2        3                    2        2      |      8  2.1|
      Fatty Change, Focal                  |          1                                1           1                  |     10  1.2|
      Focal Cellular Change                |                                        X                                 |      1     |
      Hepatodiaphragmatic Nodule           |                   X                    X                                 |      4     |
      Mixed Cell Focus                     |          2                                                               |      5  2.0|
      Necrosis                             |                                                                          |      1  1.0|
      Pigmentation                         |                                                                          |      2  2.0|
      Regeneration, Focal                  |                                                          2               |      1  2.0|
      Bile Duct, Hyperplasia               | 2        2           2        2           2  2              2            |     12  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                         +                       +                        |   6        |
      Artery, Pigmentation                 |                                                                          |      1  2.0|
      Artery, Thrombosis                   |                                                                          |      1  2.0|
      Fat, Inflammation, Chronic Active    |                                                                          |      1  2.0|
      Fat, Mineralization                  |                         1                                                |      1  1.0|
      Fat, Necrosis                        |                         2                       3                        |      4  2.5|
      Fat, Pigmentation                    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acinus, Atrophy                      |                               2                                          |      1  2.0|
      Acinus, Hyperplasia                  |                                                                          |      2  2.5|
      Artery, Pigmentation                 |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acinus, Hypertrophy                  |                                              1           1               |      2  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   6                                                               
NTP Experiment-Test: 05030-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             PROBENECID                                        Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 15:49:49  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 6| 6| 7| 7| 7| 6| 5| 7| 6| 6| 6| 5| 7| 7| 7| 6| 5| 7| 7| 6| 7| 3|            |
                             DAY ON TEST   | 3| 3| 7| 5| 3| 3| 3| 0| 6| 4| 3| 6| 7| 5| 7| 3| 3| 2| 2| 2| 3| 3| 4| 2| 5|            |
                                           | 5| 6| 5| 2| 6| 5| 5| 4| 3| 4| 5| 3| 7| 2| 9| 5| 6| 0| 0| 9| 5| 5| 9| 2| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     FEMALE                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Acinus, Inflammation, Chronic Active |                               1                                          |      1  1.0|
      Acinus, Necrosis                     |                                                                          |      2  1.0|
      Duct, Inflammation, Chronic Active   |                                                 1                        |      5  1.4|
      Duct, Metaplasia, Squamous           |                   1  1        1  1        1  1  1  1                 2   |     18  1.3|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Acanthosis                           |       2                                                                  |      2  1.5|
      Hyperkeratosis                       |       2                                                                  |      2  2.0|
      Necrosis                             |       2                                                  2               |      2  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mineralization                       |                                     1                                    |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       | 2  2  2  2     2  2  2  2  2  2  2  2        2        2  2     2  1      |     32  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Vacuolization Cytoplasmic            |       2                                                                  |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|  48        |
      Hyperplasia                          |             1           2                                                |      5  1.6|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  M  +  M  +  +  +  +  M|  38        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pars Distalis, Angiectasis           |    2  3  3     2     3  2              3     3  2        2     2        3|     24  2.3|
      Pars Distalis, Cyst                  | X                             X           X           X                  |      7     |
      Pars Distalis, Hyperplasia           |             2     2           2     1        2        2  2  2            |     15  1.9|
      Pars Intermedia, Hyperplasia         |                                                             2            |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      C-Cell, Hyperplasia                  |             1     1                    2  1                              |      8  1.1|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
      Abscess                              |                                                                          |      1  2.0|
      Mineralization                       |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   7                                                               
NTP Experiment-Test: 05030-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             PROBENECID                                        Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 15:49:49  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 6| 6| 7| 7| 7| 6| 5| 7| 6| 6| 6| 5| 7| 7| 7| 6| 5| 7| 7| 6| 7| 3|            |
                             DAY ON TEST   | 3| 3| 7| 5| 3| 3| 3| 0| 6| 4| 3| 6| 7| 5| 7| 3| 3| 2| 2| 2| 3| 3| 4| 2| 5|            |
                                           | 5| 6| 5| 2| 6| 5| 5| 4| 3| 4| 5| 3| 7| 2| 9| 5| 6| 0| 0| 9| 5| 5| 9| 2| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     FEMALE                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  +  M  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +  M  +  M  M|  36        |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                                                          |      2     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   | +  +           +              +  +  +        +  +              +     +   |  23        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hypoplasia                           |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Mediastinal, Angiectasis             |                               2  2                                       |      2  2.0|
      Mediastinal, Infiltration Cellular,  |                                                                          |            |
           Plasma Cell                     |                                  3                                       |      1  3.0|
      Mediastinal, Infiltration Cellular,  |                                                                          |            |
           Histiocyte                      |                               2                                          |      3  2.0|
      Pancreatic, Depletion Lymphoid       |                                                                          |      1  2.0|
      Pancreatic, Hematopoietic Cell       |                                                                          |            |
          Proliferation                    |                                                                          |      1  2.0|
      Pancreatic, Infiltration Cellular,   |                                                                          |            |
           Histiocyte                      |                               1                                          |      2  1.5|
      Renal, Angiectasis                   |                               2                                          |      3  2.0|
      Renal, Infiltration Cellular,        |                                                                          |            |
          Histiocyte                       |                               2                                          |      4  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Angiectasis                          |                                                                          |      2  2.0|
      Depletion Lymphoid                   |                                                                          |      1  2.0|
      Infiltration Cellular, Histiocyte    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Depletion Lymphoid                   |       2                                                                  |      3  2.0|
      Fibrosis                             |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     |    2     2  2  2  2  2  2  2  2  3  2  1     2  2  1        2        2  3|     38  2.1|
      Hemorrhage                           |                                                                          |      2  2.0|
      Infiltration Cellular, Histiocyte    |       2  2                    2        2           2           3         |      9  2.2|
      Necrosis                             |                                                                   2      |      2  2.5|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Depletion Lymphoid                   |                                                                          |      2  2.5|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   8                                                               
NTP Experiment-Test: 05030-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             PROBENECID                                        Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 15:49:49  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 6| 6| 7| 7| 7| 6| 5| 7| 6| 6| 6| 5| 7| 7| 7| 6| 5| 7| 7| 6| 7| 3|            |
                             DAY ON TEST   | 3| 3| 7| 5| 3| 3| 3| 0| 6| 4| 3| 6| 7| 5| 7| 3| 3| 2| 2| 2| 3| 3| 4| 2| 5|            |
                                           | 5| 6| 5| 2| 6| 5| 5| 4| 3| 4| 5| 3| 7| 2| 9| 5| 6| 0| 0| 9| 5| 5| 9| 2| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     FEMALE                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|  47        |
      Galactocele                          | X  X  X  X  X  X  X  X  X     X  X  X  X  X        X     X     X         |     36     |
      Acinus, Hyperplasia                  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
      Artery, Pigmentation                 |                                                                          |      1  2.0|
      Artery, Thrombosis                   |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Brain Stem, Hemorrhage               |                                                                          |      1  2.0|
      Cerebrum, Necrosis                   |             3                                                            |      2  2.5|
      Medulla, Hemorrhage                  |                                           3                              |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |       1  2     2  2     2                          2                     |      6  1.8|
      Embolus Tumor                        |                                                                          |      1     |
      Hemorrhage                           |                                  2                                       |      2  1.5|
      Infiltration Cellular, Histiocyte    |                            2                                      2      |      3  1.7|
      Alveolar Epithelium, Hyperplasia     |                         2     2                                          |      2  2.0|
      Mediastinum, Atypia Cellular         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Chronic Active         |          1                                                               |      1  1.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                            +                          +  +              +|   6        |
                                            __________________________________________________________________________|____________|
   Eye                                     |             +              +     +  +                 +  +  +           +|  11        |
      Hemorrhage                           |                                                             2            |      1  2.0|
      Lens, Cataract                       |             2                    2                                       |      3  2.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                               +     +                 +  +               |   6        |
      Hyperplasia                          |                               2                                          |      2  2.0|
      Inflammation, Chronic Active         |                                                                          |      1  1.0|
      Pigmentation                         |                               2                                          |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page   9                                                               
NTP Experiment-Test: 05030-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             PROBENECID                                        Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 15:49:49  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 6| 6| 7| 7| 7| 6| 5| 7| 6| 6| 6| 5| 7| 7| 7| 6| 5| 7| 7| 6| 7| 3|            |
                             DAY ON TEST   | 3| 3| 7| 5| 3| 3| 3| 0| 6| 4| 3| 6| 7| 5| 7| 3| 3| 2| 2| 2| 3| 3| 4| 2| 5|            |
                                           | 5| 6| 5| 2| 6| 5| 5| 4| 3| 4| 5| 3| 7| 2| 9| 5| 6| 0| 0| 9| 5| 5| 9| 2| 4|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     FEMALE                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                                                          |      1  2.0|
      Hydronephrosis                       |                                                                          |      1  2.0|
      Nephropathy                          |    1  1  2  1  1  2  1  1     1  1  1  2  1  2  2        1  2  1  1      |     41  1.4|
      Cortex, Mineralization               |                      1                    1     1                        |      4  1.0|
      Papilla, Mineralization              | 1     1           2     1     1                       1           2      |     18  1.2|
      Pelvis, Mineralization               | 1  1  1  1  1  1  1  1  1     1  1  1  1  1  1  1  1  1        1  1  1   |     43  1.0|
      Renal Tubule, Pigmentation           | 1  1     1  1  1  1  1  1  1  1  1  1  1  2  1  1  1  1  1  1  1  1  1  1|     48  1.1|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |             2                             2                              |      2  2.0|
      Inflammation, Acute                  |                                           3                              |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  10                                                               
NTP Experiment-Test: 05030-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             PROBENECID                                        Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 15:49:49  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 9| 3| 3| 2| 2| 0| 3| 3| 3| 3| 3| 2| 3| 3| 0| 5| 3| 3| 3| 3| 3|             
                                           | 4| 4| 4| 4| 3| 4| 4| 2| 2| 8| 4| 4| 4| 3| 7| 9| 4| 4| 3| 1| 4| 4| 4| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    .1 G/KG                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     LF                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         |             +                             +           +  +               |             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |             +                             +           +  +               |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |             +                             +           +  +               |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |             +                             +           +  +               |             
      Parasite                             |             2                                                            |             
                                            __________________________________________________________________________|             
   Intestine Small                         |             +              +              +           +  +               |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |             +                             +           +  +               |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |             +                             +           +  +               |             
      Lymphoid Tissue, Hyperplasia         |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |             +              +              +           +  +               |             
      Lymphoid Nodule, Hyperplasia         |                            2                                             |             
                                            __________________________________________________________________________|             
   Liver                                   |    +        +  +  +  +     +  +        +  +  +     +  +  +        +     +|             
      Angiectasis                          |    2                                                                     |             
      Basophilic Focus                     |    X        X  X  X  X        X        X  X  X     X  X  X               |             
      Clear Cell Focus                     |                                                                          |             
      Fatty Change, Diffuse                |                            2                                             |             
      Fatty Change, Focal                  |    1                 1                    1                             2|             
      Hepatodiaphragmatic Nodule           |                X     X        X                                          |             
      Mixed Cell Focus                     |                X     X                                                   |             
      Pigmentation                         |                                                    2                     |             
      Bile Duct, Hyperplasia               |                               2        2           2                     |             
                                            __________________________________________________________________________|             
   Mesentery                               |                   +                                            +         |             
      Fat, Necrosis                        |                   3                                            2         |             
                                            __________________________________________________________________________|             
   Pancreas                                |             +              +           +  +           +  +               |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +           +                             +           +  +               |             
      Duct, Inflammation, Acute            | 1                                                                        |             
      Duct, Metaplasia, Squamous           | 2                                                     1                  |             
                                            __________________________________________________________________________|             
   Stomach                                 |             +                             +           +  +               |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |             +                             +           +  +               |             
      Hyperkeratosis                       |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |             +                             +           +  +               |             
      Hyperplasia                          |                                                       2                  |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |             +                             +           +  +               |             
      Cardiomyopathy                       |                                           2              2               |             
      Mineralization                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |             +     +        +           +  +           +  +               |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |             +     +        +           +  +           +  +               |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |             +     +        +           +  +           +  +               |             
      Hyperplasia                          |                                        1                                 |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  11                                                               
NTP Experiment-Test: 05030-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             PROBENECID                                        Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 15:49:49  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 9| 3| 3| 2| 2| 0| 3| 3| 3| 3| 3| 2| 3| 3| 0| 5| 3| 3| 3| 3| 3|             
                                           | 4| 4| 4| 4| 3| 4| 4| 2| 2| 8| 4| 4| 4| 3| 7| 9| 4| 4| 3| 1| 4| 4| 4| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    .1 G/KG                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     LF                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |             +              +              +           +  +               |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +     +  +  +  +  +  +  +  +  +     +  M     +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |    3  3     1     2  2        3  3  2           3     3           3     2|             
      Pars Distalis, Cyst                  |                X                          X                              |             
      Pars Distalis, Hyperplasia           |       2     1  2                             2     2        2            |             
      Pars Nervosa, Cyst                   |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |    1           1  1  1              1           2           1     2      |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |             +  +                          M     +     +  M              +|             
      Hyperplasia                          |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   |             +        +                    +           +  +        +      |             
      Cyst                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  |             +              +     +        +           +  +           +  +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |             +                             +           +  +               |             
                                            __________________________________________________________________________|             
   Lymph Node                              |             +  +  +  +  +  +  +        +  +           +  +     +         |             
      Lumbar, Infiltration Cellular,       |                                                                          |             
          Plasma Cell                      |                                                                          |             
      Mandibular, Infiltration Cellular,   |                                                                          |             
           Plasma Cell                     |                                                          3               |             
      Mediastinal, Infiltration Cellular,  |                                                                          |             
           Plasma Cell                     |                                                                          |             
      Pancreatic, Infiltration Cellular,   |                                                                          |             
           Histiocyte                      |                                                                          |             
      Renal, Infiltration Cellular,        |                                                                          |             
          Histiocyte                       |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |             +  +     +  +  +  +        +  +           +  +     +         |             
      Angiectasis                          |                      2  2                                                |             
      Depletion Lymphoid                   |                2                                                         |             
      Infiltration Cellular, Histiocyte    |                2              2                       2        2         |             
                                            __________________________________________________________________________|             
   Spleen                                  |             +  +  +        +           +  +        +  +  +     +        +|             
      Angiectasis                          |                                                                          |             
      Depletion Lymphoid                   |                                                                          |             
      Hematopoietic Cell Proliferation     |             1                             2           2                  |             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  12                                                               
NTP Experiment-Test: 05030-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             PROBENECID                                        Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 15:49:49  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 9| 3| 3| 2| 2| 0| 3| 3| 3| 3| 3| 2| 3| 3| 0| 5| 3| 3| 3| 3| 3|             
                                           | 4| 4| 4| 4| 3| 4| 4| 2| 2| 8| 4| 4| 4| 3| 7| 9| 4| 4| 3| 1| 4| 4| 4| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    .1 G/KG                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     LF                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Infiltration Cellular, Histiocyte    |                                                       2                  |             
      Necrosis                             |                                                                          |             
      Pigmentation                         |             2  3                                      3                  |             
                                            __________________________________________________________________________|             
   Thymus                                  |             +                          +  +           +  +               |             
      Depletion Lymphoid                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |             +        +  +  +  +     +     +           +  +  +           +|             
      Galactocele                          |                      X     X        X                    X  X            |             
      Acinus, Hyperplasia                  |                                     2                                    |             
                                            __________________________________________________________________________|             
   Skin                                    |             +                       +     +           +  +               |             
      Acanthosis                           |                                     2                                    |             
      Hyperkeratosis                       |                                     3                                    |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |             +                             +           +  +               |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |             +                             +           +  +               |             
      Inflammation, Acute                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |       +  +  +     +  +                    +     +  +  +  +           +   |             
      Congestion                           |          2  2        2                          2                        |             
      Hemorrhage                           |                                                                      1   |             
      Inflammation, Chronic Active         |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |             2        2                                                   |             
                                            __________________________________________________________________________|             
   Nose                                    |             +                             +           +  +               |             
                                            __________________________________________________________________________|             
   Trachea                                 |       +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                            +                                      +      |             
                                            __________________________________________________________________________|             
   Eye                                     |    +                       +  +        +                    +     +     +|             
      Synechia                             |                                                                          |             
      Lens, Cataract                       |                            2                                      2      |             
      Retina, Atrophy                      |    2                                                        2            |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                        +                                 |             
      Pigmentation                         |                                        2                                 |             
                                            __________________________________________________________________________|             
   Lacrimal Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy                          |    1  1           2     1  1  1  1        1  1  1  1  1  1     1  2  1  2|             
      Pigmentation                         |                                     X                                    |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  13                                                               
NTP Experiment-Test: 05030-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             PROBENECID                                        Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 15:49:49  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 5| 7| 7| 7| 6| 5| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 3| 3| 3| 3| 9| 3| 3| 2| 2| 0| 3| 3| 3| 3| 3| 2| 3| 3| 0| 5| 3| 3| 3| 3| 3|             
                                           | 4| 4| 4| 4| 3| 4| 4| 2| 2| 8| 4| 4| 4| 3| 7| 9| 4| 4| 3| 1| 4| 4| 4| 4| 4|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    .1 G/KG                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     LF                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Cortex, Mineralization               |                                        1  1                              |             
      Papilla, Mineralization              |                      1     1  1                                   1      |             
      Pelvis, Mineralization               | 1  1  2  1  1  1     1  1  1     1     1     1     1  1  1  1  1         |             
      Renal Tubule, Pigmentation           | 1  1  2  2  2  2  2  1  1  1  2  2     2  1  2  1  1  1  1  1  1  2  1  1|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |             +                             M           +  +               |             
      Mineralization                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  14                                                               
NTP Experiment-Test: 05030-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             PROBENECID                                        Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 15:49:49  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 6| 0| 7| 7| 6| 5| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|            |
                             DAY ON TEST   | 7| 3| 3| 9| 9| 3| 3| 9| 9| 8| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1|            |
                                           | 2| 4| 4| 9| 7| 4| 4| 1| 2| 5| 4| 4| 4| 4| 1| 4| 4| 4| 4| 4| 4| 4| 4| 3| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|      A     |
    .1 G/KG                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     LF                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +           +           +  +                                            +|   9        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +           +           +  +                                            +|   9        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +           +           +  +                                            +|   9        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +           +           +  M                                            +|   8        |
      Parasite                             |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +           +           +  +                                         +  +|  11        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +           +           +  +                                            +|   9        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +           +           +  +                                         +  +|  10        |
      Lymphoid Tissue, Hyperplasia         |                                                                      2   |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +           +           +  +                                         +  +|  11        |
      Lymphoid Nodule, Hyperplasia         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +     +        +  +  +           +  +     +  +     +  +  +        +|  30        |
      Angiectasis                          |                                                                          |      1  2.0|
      Basophilic Focus                     |    X  X                 X              X  X     X        X  X            |     20     |
      Clear Cell Focus                     |    X                                                                     |      1     |
      Fatty Change, Diffuse                |                      2                                                   |      2  2.0|
      Fatty Change, Focal                  |       1                                                     2           2|      7  1.4|
      Hepatodiaphragmatic Nodule           |    X                                   X  X     X                        |      7     |
      Mixed Cell Focus                     |                                                                          |      2     |
      Pigmentation                         |                                                                          |      1  2.0|
      Bile Duct, Hyperplasia               |    2                                      2     2           2            |      7  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   2        |
      Fat, Necrosis                        |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +           +        +  +  +              +                       +     +|  14        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +           +           +  +                                            +|  10        |
      Duct, Inflammation, Acute            |                                                                          |      1  1.0|
      Duct, Metaplasia, Squamous           |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +           +           +  +                                            +|   9        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +           +           +  +                                            +|   9        |
      Hyperkeratosis                       |                            1                                             |      1  1.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +           +           +  +                                            +|   9        |
      Hyperplasia                          |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +           +           +  +                                            +|   9        |
      Cardiomyopathy                       |                         2                                                |      3  2.0|
      Mineralization                       |                            3                                             |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  15                                                               
NTP Experiment-Test: 05030-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             PROBENECID                                        Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 15:49:49  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 6| 0| 7| 7| 6| 5| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|            |
                             DAY ON TEST   | 7| 3| 3| 9| 9| 3| 3| 9| 9| 8| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1|            |
                                           | 2| 4| 4| 9| 7| 4| 4| 1| 2| 5| 4| 4| 4| 4| 1| 4| 4| 4| 4| 4| 4| 4| 4| 3| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|      A     |
    .1 G/KG                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     LF                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +           +           +  +                          +                 +|  13        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +           +           +  +                          +                 +|  13        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +           +           +  +                          +                 +|  13        |
      Hyperplasia                          |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +           +           +  +                                      +     +|  11        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  M  +  +  +  +  M  +  +  +     +  +  +  +  +  +  +  +  +  +  +|  43        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pars Distalis, Angiectasis           |    2  3        2  2  2  2        3                          2  2  2  2  2|     24  2.3|
      Pars Distalis, Cyst                  |                                                    X                     |      3     |
      Pars Distalis, Hyperplasia           |                2  2           2              2  1  2        2            |     13  1.8|
      Pars Nervosa, Cyst                   |                                                                X         |      1     |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      C-Cell, Hyperplasia                  |                1                             1     1     1           1   |     13  1.2|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +        +  M        +  M  +     +        +        +        +  +     +  +|  16        |
      Hyperplasia                          |                                                             4            |      1  4.0|
      Inflammation, Acute                  |                                  3                          3        4   |      3  3.3|
      Necrosis                             |                                                    3                     |      1  3.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +           +  +        +  +     +           +                 +     +  +|  16        |
      Cyst                                 |                                                                      X   |      1     |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +           +        +  +  +           +              +                 +|  16        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | M           +           +  +                                            +|   8        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +           +        +  +  +              +        +                 +  +|  21        |
      Lumbar, Infiltration Cellular,       |                                                                          |            |
          Plasma Cell                      |                                                                      2   |      1  2.0|
      Mandibular, Infiltration Cellular,   |                                                                          |            |
           Plasma Cell                     |                                                                          |      1  3.0|
      Mediastinal, Infiltration Cellular,  |                                                                          |            |
           Plasma Cell                     |                                                                      2   |      1  2.0|
      Pancreatic, Infiltration Cellular,   |                                                                          |            |
           Histiocyte                      |                                           2                              |      1  2.0|
      Renal, Infiltration Cellular,        |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  16                                                               
NTP Experiment-Test: 05030-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             PROBENECID                                        Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 15:49:49  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 6| 0| 7| 7| 6| 5| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|            |
                             DAY ON TEST   | 7| 3| 3| 9| 9| 3| 3| 9| 9| 8| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1|            |
                                           | 2| 4| 4| 9| 7| 4| 4| 1| 2| 5| 4| 4| 4| 4| 1| 4| 4| 4| 4| 4| 4| 4| 4| 3| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|      A     |
    .1 G/KG                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     LF                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
          Histiocyte                       |                                           2                          2   |      2  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +           +        +  +  +              +        +                 +  +|  20        |
      Angiectasis                          |                                                                          |      2  2.0|
      Depletion Lymphoid                   |                                                                          |      1  2.0|
      Infiltration Cellular, Histiocyte    |                         1                 2                          2   |      7  1.9|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +           +        +  +  +           +        +  +  +  +  +           +|  23        |
      Angiectasis                          |                                                             2            |      1  2.0|
      Depletion Lymphoid                   |                            2                                             |      1  2.0|
      Hematopoietic Cell Proliferation     |                         2                             2     2            |      6  1.8|
      Hemorrhage                           |                                                          3               |      1  3.0|
      Infiltration Cellular, Histiocyte    |                            3                                             |      2  2.5|
      Necrosis                             |                                                    3                     |      1  3.0|
      Pigmentation                         |                                                       2                  |      4  2.5|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +           +           +  +                                            +|  10        |
      Depletion Lymphoid                   |                            2                                             |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +        +  +  +     +  +     +  +     +  +        +     +  +|  28        |
      Galactocele                          | X     X              X  X                          X           X     X  X|     13     |
      Acinus, Hyperplasia                  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +        +  +        +  +                                            +|  12        |
      Acanthosis                           |                                                                          |      1  2.0|
      Hyperkeratosis                       |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | M           +           +  +                                            +|   8        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +           +           +  +              +                             +|  10        |
      Inflammation, Acute                  | 1                                                                        |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +     +     +     +     +  +  +     +  +  +     +  +  +  +              +|  26        |
      Congestion                           |                               2     2  2  2           2  2               |     10  2.0|
      Hemorrhage                           |                            1                                             |      2  1.0|
      Inflammation, Chronic Active         |                            3                                             |      1  3.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +           +           +  +                                            +|   9        |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  17                                                               
NTP Experiment-Test: 05030-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             PROBENECID                                        Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 15:49:49  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 5| 7| 7| 6| 0| 7| 7| 6| 5| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6|            |
                             DAY ON TEST   | 7| 3| 3| 9| 9| 3| 3| 9| 9| 8| 3| 3| 3| 3| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1|            |
                                           | 2| 4| 4| 9| 7| 4| 4| 1| 2| 5| 4| 4| 4| 4| 1| 4| 4| 4| 4| 4| 4| 4| 4| 3| 7|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|      A     |
    .1 G/KG                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     LF                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                      +                    +                              |   4        |
                                            __________________________________________________________________________|____________|
   Eye                                     |    +                 +  +                 +        +                 +   |  13        |
      Synechia                             |                                           2        2                     |      2  2.0|
      Lens, Cataract                       |                      2                    2                              |      4  2.0|
      Retina, Atrophy                      |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |    +                 +  +                          +                     |   5        |
      Pigmentation                         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lacrimal Gland                          |                                                    +                     |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Nephropathy                          |    1  1        1  1  1           1  1  1  1  1  1     1     1     1  1  1|     33  1.1|
      Pigmentation                         |                                                                          |      1     |
      Cortex, Mineralization               |                               1                                          |      3  1.0|
      Papilla, Mineralization              | 1                             1     1  1  1                             1|     10  1.0|
      Pelvis, Mineralization               |    1  1        1        1           2  1  1  1           1  1  1  1  1   |     30  1.1|
      Renal Tubule, Pigmentation           | 2  2  1  1     1  1  2  1     1  1  1  1  1  1  1  1  1  1  1  1  2  2  2|     47  1.3|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +           +           +  +                                            +|   8        |
      Mineralization                       |             1                                                            |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  18                                                               
NTP Experiment-Test: 05030-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             PROBENECID                                        Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 15:49:49  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 6| 1| 7| 7| 7| 7| 6| 7| 7| 6| 5| 5| 7| 7| 6| 4| 2| 7| 7| 6| 2| 2|             
                             DAY ON TEST   | 3| 9| 3| 0| 3| 3| 3| 3| 2| 3| 3| 3| 7| 5| 2| 3| 3| 2| 9| 1| 3| 3| 9| 8| 6|             
                                           | 3| 5| 7| 3| 5| 4| 4| 3| 2| 9| 4| 4| 7| 7| 6| 4| 4| 4| 5| 6| 4| 4| 8| 8| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    .4 G/KG                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     HF                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Inflammation, Chronic Active         |                                                                      1   |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  A|             
      Parasite                             |                                           1                              |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite                             |          1           1                    1  1     2           2         |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|             
      Lymphoid Nodule, Hyperplasia         |                                           2                              |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  A|             
      Lymphoid Nodule, Hyperplasia         |                                        2                                 |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |    X  X  X     X  X  X  X  X  X           X  X        X           X      |             
      Clear Cell Focus                     |                                                                          |             
      Congestion                           |                                           2                              |             
      Fatty Change, Diffuse                |                                     2                                    |             
      Fatty Change, Focal                  |                                  1                             1         |             
      Hepatodiaphragmatic Nodule           | X                             X                                          |             
      Mixed Cell Focus                     |                                  X              X  X           X         |             
      Necrosis                             |                                                                          |             
      Regeneration, Focal                  |                                                                   2      |             
      Bile Duct, Hyperplasia               |                      2              2                             2      |             
                                            __________________________________________________________________________|             
   Mesentery                               |          +     +                                                         |             
      Fat, Hemorrhage                      |                                                                          |             
      Fat, Mineralization                  |                                                                          |             
      Fat, Necrosis                        |          3     3                                                         |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |                               2                                          |             
      Acinus, Hyperplasia                  |                                                                         2|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Acinus, Inflammation, Chronic Active |                               1                                          |             
      Duct, Inflammation, Chronic Active   |                                                                          |             
      Duct, Metaplasia, Squamous           | 2                             1  1           2  1  1        1  1         |             
      Duct, Mineralization                 |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                                                          |             
      Hemorrhage                           |                                                                         1|             
      Inflammation, Chronic Active         |                                                                         2|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|             
      Necrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  19                                                               
NTP Experiment-Test: 05030-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             PROBENECID                                        Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 15:49:49  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 6| 1| 7| 7| 7| 7| 6| 7| 7| 6| 5| 5| 7| 7| 6| 4| 2| 7| 7| 6| 2| 2|             
                             DAY ON TEST   | 3| 9| 3| 0| 3| 3| 3| 3| 2| 3| 3| 3| 7| 5| 2| 3| 3| 2| 9| 1| 3| 3| 9| 8| 6|             
                                           | 3| 5| 7| 3| 5| 4| 4| 3| 2| 9| 4| 4| 7| 7| 6| 4| 4| 4| 5| 6| 4| 4| 8| 8| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    .4 G/KG                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     HF                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                       +                  |             
      Artery, Inflammation, Chronic Active |                                                       2                  |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 2  2     2     2  2  2  2  3  2  2  2     1     2           3            |             
      Mineralization                       |                                                          1               |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                         2|             
      Hemorrhage                           |                                                                          |             
      Vacuolization Cytoplasmic            |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Hyperplasia                          |    1                             1  1                                    |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  +  +  M  +  +  M  M  M  +  +  +  +  +  +  M  +  +  +  M  +  +  +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           | 3  2  2        3     2                 2                          2      |             
      Pars Distalis, Cyst                  |          X                                         X                     |             
      Pars Distalis, Hyperplasia           |          2                    2  2     2        2  2           2         |             
      Pars Intermedia, Angiectasis         |                                                                          |             
      Pars Intermedia, Hyperplasia         |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  M  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |                         1                                                |             
      C-Cell, Hyperplasia                  |                      1                                      1  1         |             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|             
      Inflammation, Chronic Active         |                                                                1         |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                X                                            X            |             
      Pigmentation                         |                                     3                                    |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Decidual Reaction                    |                                                    X                     |             
      Hemorrhage                           |                                              2                           |             
      Bilateral, Abscess                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  20                                                               
NTP Experiment-Test: 05030-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             PROBENECID                                        Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 15:49:49  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 6| 1| 7| 7| 7| 7| 6| 7| 7| 6| 5| 5| 7| 7| 6| 4| 2| 7| 7| 6| 2| 2|             
                             DAY ON TEST   | 3| 9| 3| 0| 3| 3| 3| 3| 2| 3| 3| 3| 7| 5| 2| 3| 3| 2| 9| 1| 3| 3| 9| 8| 6|             
                                           | 3| 5| 7| 3| 5| 4| 4| 3| 2| 9| 4| 4| 7| 7| 6| 4| 4| 4| 5| 6| 4| 4| 8| 8| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    .4 G/KG                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     HF                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Endometrium, Hyperplasia, Adenomatous|                                              3                           |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   | +              +  +  +        +  +           +  +           +  +         |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mandibular, Hematopoietic Cell       |                                                                          |             
          Proliferation                    |                                                                          |             
      Mediastinal, Infiltration Cellular,  |                                                                          |             
           Histiocyte                      |                                     3                                    |             
      Pancreatic, Infiltration Cellular,   |                                                                          |             
           Histiocyte                      |                                                    2              2      |             
      Renal, Infiltration Cellular,        |                                                                          |             
          Histiocyte                       |                                     3                             3      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Depletion Lymphoid                   |                                     2                                    |             
      Infiltration Cellular, Mast Cell     |                                                    2                     |             
      Infiltration Cellular, Histiocyte    |                         2           2                             2      |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Depletion Lymphoid                   |                                           2              2           2   |             
      Hematopoietic Cell Proliferation     | 2  2     1     2     1  2        2  2           2  2                     |             
      Hemorrhage                           |                                                                          |             
      Infiltration Cellular, Histiocyte    |       3     3                          3  2              2           3  3|             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Depletion Lymphoid                   |                                        4                                 |             
      Hemorrhage                           |             3                                            3               |             
      Necrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  M  +  M  M|             
      Galactocele                          |    X                 X              X                             X      |             
      Acinus, Hyperplasia                  |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                                                                          |             
      Hyperkeratosis                       |                                                                          |             
      Necrosis                             |    3                                                                     |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  21                                                               
NTP Experiment-Test: 05030-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             PROBENECID                                        Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 15:49:49  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 6| 1| 7| 7| 7| 7| 6| 7| 7| 6| 5| 5| 7| 7| 6| 4| 2| 7| 7| 6| 2| 2|             
                             DAY ON TEST   | 3| 9| 3| 0| 3| 3| 3| 3| 2| 3| 3| 3| 7| 5| 2| 3| 3| 2| 9| 1| 3| 3| 9| 8| 6|             
                                           | 3| 5| 7| 3| 5| 4| 4| 3| 2| 9| 4| 4| 7| 7| 6| 4| 4| 4| 5| 6| 4| 4| 8| 8| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    .4 G/KG                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     HF                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                       2                  |             
      Cerebrum, Hemorrhage                 |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                        +                                 |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atelectasis                          |                                  3                                       |             
      Congestion                           |             2                                            3               |             
      Edema                                |                            1        2                    2              2|             
      Fibrosis                             |                                     2                                    |             
      Hemorrhage                           |                                  1  1     3                             3|             
      Infiltration Cellular, Histiocyte    |                            3     2                                       |             
      Inflammation, Chronic Active         |                            2        2                                    |             
      Mineralization                       |                                  1                                       |             
      Alveolar Epithelium, Hyperplasia     |                                     2                                    |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |          2                             2                                 |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                         +|             
                                            __________________________________________________________________________|             
   Eye                                     |    +                                               +              +      |             
      Synechia                             |                                                                          |             
      Lens, Cataract                       |                                                                   3      |             
      Retina, Atrophy                      |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |    +                                               +              +      |             
      Pigmentation                         |                                                                   2      |             
                                            __________________________________________________________________________|             
   Lacrimal Gland                          |    +                                                                     |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Nephropathy                          | 1  1  2        1  1  1  1     1  1  2        1  2           1  1  1      |             
      Cortex, Inflammation, Acute          |                                                                          |             
      Cortex, Mineralization               |             2                       1     1  1                          1|             
      Papilla, Mineralization              | 1        1  1  1        1        1  1  1  1        1        1  1  2      |             
      Papilla, Necrosis                    |                                                                          |             
      Pelvis, Mineralization               | 1  1  1        1     1  1     1  1  1  1     1  1  1        1  1  1  1   |             
      Renal Tubule, Pigmentation           | 2  1  2  2  1  1  2  2  2     1  2  2  1  1  2  2  2  1     2  1  2  1   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  M  +  +  +  +  A  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Necrosis                             |                                                                          |             
      Transitional Epithelium, Hyperplasia |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  22                                                               
NTP Experiment-Test: 05030-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             PROBENECID                                        Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 15:49:49  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 5| 0| 7| 6| 6| 5| 5| 7| 7| 5| 2| 2| 7| 7| 7| 6| 6| 7| 7| 7| 6| 2|            |
                             DAY ON TEST   | 2| 0| 5| 9| 9| 3| 4| 0| 9| 1| 3| 3| 6| 7| 6| 3| 3| 3| 7| 0| 3| 3| 3| 5| 0|            |
                                           | 1| 5| 2| 2| 4| 2| 9| 5| 2| 2| 4| 4| 1| 0| 6| 4| 4| 4| 0| 4| 4| 4| 4| 8| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      A     |
    .4 G/KG                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     HF                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Inflammation, Chronic Active         |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +|  44        |
      Parasite                             |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Parasite                             |                               1              1              1            |      9  1.2|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  A  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +|  45        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  A  +  +  +  +  +  +  +  +  A  M  +  +  +  +  +  +  +  +  A  +|  44        |
      Lymphoid Nodule, Hyperplasia         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +|  44        |
      Lymphoid Nodule, Hyperplasia         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     | X     X        X     X  X  X     X           X  X  X  X     X  X  X      |     27     |
      Clear Cell Focus                     |                                                                   X      |      1     |
      Congestion                           |                                                                          |      1  2.0|
      Fatty Change, Diffuse                |                                                                          |      1  2.0|
      Fatty Change, Focal                  |                                                       1                  |      3  1.0|
      Hepatodiaphragmatic Nodule           |          X                    X                                X         |      5     |
      Mixed Cell Focus                     |                               X                                          |      5     |
      Necrosis                             |    4                                                                    1|      2  2.5|
      Regeneration, Focal                  |                                     2                                    |      2  2.0|
      Bile Duct, Hyperplasia               |       2        2              2                                2         |      7  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |       +        +                                      +                 +|   6        |
      Fat, Hemorrhage                      |                                                                         2|      1  2.0|
      Fat, Mineralization                  |                2                                                         |      1  2.0|
      Fat, Necrosis                        |                4                                      3                  |      4  3.3|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acinus, Atrophy                      |                                                                          |      1  2.0|
      Acinus, Hyperplasia                  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Acinus, Inflammation, Chronic Active |                                                                          |      1  1.0|
      Duct, Inflammation, Chronic Active   |                                                             1            |      1  1.0|
      Duct, Metaplasia, Squamous           | 1                                         2  1     1        2            |     13  1.3|
      Duct, Mineralization                 | 1                                                                        |      1  1.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|  49        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  23                                                               
NTP Experiment-Test: 05030-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             PROBENECID                                        Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 15:49:49  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 5| 0| 7| 6| 6| 5| 5| 7| 7| 5| 2| 2| 7| 7| 7| 6| 6| 7| 7| 7| 6| 2|            |
                             DAY ON TEST   | 2| 0| 5| 9| 9| 3| 4| 0| 9| 1| 3| 3| 6| 7| 6| 3| 3| 3| 7| 0| 3| 3| 3| 5| 0|            |
                                           | 1| 5| 2| 2| 4| 2| 9| 5| 2| 2| 4| 4| 1| 0| 6| 4| 4| 4| 0| 4| 4| 4| 4| 8| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      A     |
    .4 G/KG                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     HF                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Acanthosis                           |    2                                                                     |      1  2.0|
      Hemorrhage                           |                                                                          |      1  1.0|
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Necrosis                             |    2                                                                     |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   1        |
      Artery, Inflammation, Chronic Active |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       | 2  2  2        2     2     2  2  2  2           2  2  2  2  2  2  2  2   |     31  2.0|
      Mineralization                       |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|  49        |
      Congestion                           |                                                                          |      1  2.0|
      Hemorrhage                           |             2                                                            |      1  2.0|
      Vacuolization Cytoplasmic            |          2                                            2                  |      2  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|  45        |
      Hyperplasia                          |    1     1                                   2                           |      6  1.2|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                                                 3                        |      1  3.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  M  +  +  +  M  M  +  +  M  +  M  +  +  +  +  +  +  +  M  M  M|  34        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pars Distalis, Angiectasis           |    2           3                             2  3     2  2     2     2   |     15  2.3|
      Pars Distalis, Cyst                  |                                                          X     X         |      4     |
      Pars Distalis, Hyperplasia           | 2                                2                       2     2         |     11  2.0|
      Pars Intermedia, Angiectasis         |                                              1                           |      1  1.0|
      Pars Intermedia, Hyperplasia         | 2                                                                        |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|  47        |
      Mineralization                       |                                                                          |      1  1.0|
      C-Cell, Hyperplasia                  |                                                                1         |      4  1.0|
      Follicular Cell, Hyperplasia         |                                              3           1               |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  24                                                               
NTP Experiment-Test: 05030-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             PROBENECID                                        Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 15:49:49  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 5| 0| 7| 6| 6| 5| 5| 7| 7| 5| 2| 2| 7| 7| 7| 6| 6| 7| 7| 7| 6| 2|            |
                             DAY ON TEST   | 2| 0| 5| 9| 9| 3| 4| 0| 9| 1| 3| 3| 6| 7| 6| 3| 3| 3| 7| 0| 3| 3| 3| 5| 0|            |
                                           | 1| 5| 2| 2| 4| 2| 9| 5| 2| 2| 4| 4| 1| 0| 6| 4| 4| 4| 0| 4| 4| 4| 4| 8| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      A     |
    .4 G/KG                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     HF                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          | +  +  M  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|  45        |
      Inflammation, Chronic Active         |                                                                          |      1  1.0|
      Necrosis                             |                3                                                         |      1  3.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 | X                                            X                           |      4     |
      Pigmentation                         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Decidual Reaction                    |                                                                          |      1     |
      Hemorrhage                           |                                                                          |      1  2.0|
      Bilateral, Abscess                   |                3                                                         |      1  3.0|
      Endometrium, Hyperplasia, Adenomatous|                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                +              +  +           +  +  +        +  +         |  18        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mandibular, Hematopoietic Cell       |                                                                          |            |
          Proliferation                    |          2                                                               |      1  2.0|
      Mediastinal, Infiltration Cellular,  |                                                                          |            |
           Histiocyte                      |                         2                             2                  |      3  2.3|
      Pancreatic, Infiltration Cellular,   |                                                                          |            |
           Histiocyte                      |                                                                          |      2  2.0|
      Renal, Infiltration Cellular,        |                                                                          |            |
          Histiocyte                       |                                                                          |      2  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                         2                                                |      1  2.0|
      Depletion Lymphoid                   |                                                                          |      1  2.0|
      Infiltration Cellular, Mast Cell     |                                                                          |      1  2.0|
      Infiltration Cellular, Histiocyte    |       2        3        2                             2                  |      7  2.1|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Depletion Lymphoid                   |             2                                                           2|      5  2.0|
      Hematopoietic Cell Proliferation     |       2        2     3  2  2  2     2           2  2  2  2  2  2         |     23  2.0|
      Hemorrhage                           |    2                                                                     |      1  2.0|
      Infiltration Cellular, Histiocyte    |             2           2        3     3  2  2           3              3|     15  2.6|
      Necrosis                             |    2                                                                     |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  46        |
      Cyst                                 |                      X                                                   |      1     |
      Depletion Lymphoid                   |                                                                          |      1  4.0|
      Hemorrhage                           |                                                                          |      2  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  25                                                               
NTP Experiment-Test: 05030-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             PROBENECID                                        Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 15:49:49  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 5| 0| 7| 6| 6| 5| 5| 7| 7| 5| 2| 2| 7| 7| 7| 6| 6| 7| 7| 7| 6| 2|            |
                             DAY ON TEST   | 2| 0| 5| 9| 9| 3| 4| 0| 9| 1| 3| 3| 6| 7| 6| 3| 3| 3| 7| 0| 3| 3| 3| 5| 0|            |
                                           | 1| 5| 2| 2| 4| 2| 9| 5| 2| 2| 4| 4| 1| 0| 6| 4| 4| 4| 0| 4| 4| 4| 4| 8| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      A     |
    .4 G/KG                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     HF                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Necrosis                             |             2                                                            |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  M  +  M  +  M  +  +  +  M  +  +  M  M  +  +  +  +  M  M  +  +  +  +|  36        |
      Galactocele                          |    X                                X                                    |      6     |
      Acinus, Hyperplasia                  |                                                                      2   |      1  2.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cyst Epithelial Inclusion            |                                                 X                        |      1     |
      Hyperkeratosis                       |                                                 3                        |      1  3.0|
      Necrosis                             |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                                                          |      1  2.0|
      Cerebrum, Hemorrhage                 |                                                                         2|      1  2.0|
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atelectasis                          |                                                                          |      1  3.0|
      Congestion                           |             3                                            3              3|      5  2.8|
      Edema                                |             1                          2                 2              2|      8  1.8|
      Fibrosis                             |                                                                          |      1  2.0|
      Hemorrhage                           |                   1                                                      |      5  1.8|
      Infiltration Cellular, Histiocyte    | 1                                1              1           1            |      6  1.5|
      Inflammation, Chronic Active         |                                                                         2|      3  2.0|
      Mineralization                       |                                                                          |      1  1.0|
      Alveolar Epithelium, Hyperplasia     |                                     2           3                        |      3  2.3|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                     +                                    |   2        |
                                            __________________________________________________________________________|____________|
   Eye                                     |    +                             +  +                                    |   6        |
      Synechia                             |                                  2                                       |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  26                                                               
NTP Experiment-Test: 05030-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             PROBENECID                                        Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 15:49:49  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 6| 5| 0| 7| 6| 6| 5| 5| 7| 7| 5| 2| 2| 7| 7| 7| 6| 6| 7| 7| 7| 6| 2|            |
                             DAY ON TEST   | 2| 0| 5| 9| 9| 3| 4| 0| 9| 1| 3| 3| 6| 7| 6| 3| 3| 3| 7| 0| 3| 3| 3| 5| 0|            |
                                           | 1| 5| 2| 2| 4| 2| 9| 5| 2| 2| 4| 4| 1| 0| 6| 4| 4| 4| 0| 4| 4| 4| 4| 8| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|      A     |
    .4 G/KG                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     HF                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Lens, Cataract                       |    2                                3                                    |      3  2.7|
      Retina, Atrophy                      |                                  2                                       |      1  2.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |    +                             +  +                 +                  |   7        |
      Pigmentation                         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lacrimal Gland                          |                                                       +                  |   2        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                        X                                 |      1     |
      Nephropathy                          | 1  2  1  1     1        1  1  1              2  2  1        1  1  1  2   |     30  1.2|
      Cortex, Inflammation, Acute          |                                                                         3|      1  3.0|
      Cortex, Mineralization               | 2                                      1  1                          1  2|     10  1.3|
      Papilla, Mineralization              |          2  1     1     1           1        1        1  1  1     1     2|     24  1.1|
      Papilla, Necrosis                    |                                                                         3|      1  3.0|
      Pelvis, Mineralization               | 1  1     1     1  1        1     1        1  1  1     1           1     1|     30  1.0|
      Renal Tubule, Pigmentation           | 2  2  2  1     1  1  1  1  1  1  1  2  1  1  2  1  1  1  1  2  2  1  1  1|     46  1.4|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Hemorrhage                           |                                                                         2|      1  2.0|
      Necrosis                             |                                                                         3|      1  3.0|
      Transitional Epithelium, Hyperplasia |                                                                         1|      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  27                                                               
NTP Experiment-Test: 05030-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             PROBENECID                                        Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 15:49:49  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 2| 7| 7| 7| 7| 5|             
                             DAY ON TEST   | 3| 4| 0| 1| 4| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 4| 0| 9| 3| 3| 3| 3| 9|             
                                           | 7| 0| 7| 0| 7| 8| 7| 7| 7| 7| 8| 8| 7| 0| 6| 8| 8| 0| 8| 3| 8| 8| 8| 8| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Parasite                             |    1                                                                 1   |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     | X  X     X  X  X     X     X  X  X  X        X  X  X        X  X  X  X   |             
      Clear Cell Focus                     |                                  1                                       |             
      Congestion                           |             2                                                            |             
      Fatty Change, Diffuse                |          2        2                    3  3                    1         |             
      Fatty Change, Focal                  | 2  2        1  1     2     2     2              2     1           1     2|             
      Hepatodiaphragmatic Nodule           |                                     X                                    |             
      Mixed Cell Focus                     |       X                                                                  |             
      Necrosis                             |                                                       2                  |             
      Regeneration, Focal                  |                                                             2            |             
      Artery, Inflammation, Chronic Active |                                                          2               |             
      Bile Duct, Hyperplasia               | 2     2        2  2  2     2  2  2  2  2        2  2  2     2  2  2  2   |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                     +     +  +           +     +         |             
      Artery, Necrosis, Fibrinoid          |                                     3                    3               |             
      Fat, Necrosis                        |                                           4  3                 4         |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |                                     2                                    |             
      Acinus, Hyperplasia                  |                            2              3                              |             
      Artery, Necrosis, Fibrinoid          |                                     1                    3               |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Inflammation, Chronic Active |                                     1                                    |             
      Artery, Necrosis, Fibrinoid          |                                                          2               |             
      Duct, Inflammation, Chronic Active   |          2                       1              1                        |             
      Duct, Metaplasia, Squamous           |          1              1  1     2              2              1     1  1|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                        2                                 |             
      Hyperkeratosis                       |                                        2  2                              |             
      Inflammation, Chronic Active         |                                           2                              |             
      Necrosis                             |                                        2  3                              |             
      Artery, Necrosis, Fibrinoid          |                                                          3               |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Artery, Necrosis, Fibrinoid          |                                                          3               |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  28                                                               
NTP Experiment-Test: 05030-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             PROBENECID                                        Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 15:49:49  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 2| 7| 7| 7| 7| 5|             
                             DAY ON TEST   | 3| 4| 0| 1| 4| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 4| 0| 9| 3| 3| 3| 3| 9|             
                                           | 7| 0| 7| 0| 7| 8| 7| 7| 7| 7| 8| 8| 7| 0| 6| 8| 8| 0| 8| 3| 8| 8| 8| 8| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                          +               |             
      Artery, Necrosis, Fibrinoid          |                                                          1               |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       | 2  2  2  2  2  2  2  2        2     2  2  3              1     2  1  2  2|             
      Thrombosis                           |                                                                          |             
      Artery, Necrosis, Fibrinoid          |                                     2                                    |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                    2                     |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |    1     1                 1                                         3   |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                               2                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  M  M  M  +  +  +  +  +  +  +  +  M  +  +  +  M  M  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |          3              2                 3  2        2                  |             
      Pars Distalis, Hemorrhage            |                                           2                              |             
      Pars Distalis, Hyperplasia           |                3              2  2                 2                 2  2|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |    2                    2           1     1                              |             
      Capsule, Necrosis, Fibrinoid         |                                                          2               |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                       2                  |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Inflammation, Chronic Active         |                                                                      2   |             
      Necrosis                             |                                           2        2  3                 3|             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Inflammation, Chronic Active         |       2                             1                                    |             
      Artery, Necrosis, Fibrinoid          |                                                          2               |             
      Epithelium, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Interstitial Cell, Hyperplasia       |          2  1                             2     2              2  2  2  2|             
      Seminiferous Tubule, Atrophy         | 2  2           2     2  2  2  3  2  2        2  2     4     4  1  3  2   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  29                                                               
NTP Experiment-Test: 05030-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             PROBENECID                                        Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 15:49:49  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 2| 7| 7| 7| 7| 5|             
                             DAY ON TEST   | 3| 4| 0| 1| 4| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 4| 0| 9| 3| 3| 3| 3| 9|             
                                           | 7| 0| 7| 0| 7| 8| 7| 7| 7| 7| 8| 8| 7| 0| 6| 8| 8| 0| 8| 3| 8| 8| 8| 8| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   | +  +              +  +  +  +  +  +  +        +     +        +  +  +  +   |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mediastinal, Angiectasis             |                                                          2               |             
      Mediastinal, Infiltration Cellular,  |                                                                          |             
           Histiocyte                      |       2                                            2                     |             
      Renal, Angiectasis                   |                                           2              2               |             
      Renal, Depletion Lymphoid            |                                           2                              |             
      Renal, Infiltration Cellular,        |                                                                          |             
          Histiocyte                       |       2                                2                                 |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Hemorrhage                           |                                                          2               |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Depletion Lymphoid                   |                                                                          |             
      Hematopoietic Cell Proliferation     | 2  2                       2     2  2     2     2  2  2  2     2     2  2|             
      Infiltration Cellular, Histiocyte    |                                        3                                 |             
      Necrosis                             |                                                          2               |             
      Capsule, Fibrosis                    |                                                          2               |             
      Capsule, Inflammation, Chronic Active|                                                          2               |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Epithelial Cell, Hyperplasia         |                                                                2         |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  M  M  M  M  +  M  M  M  +  +  +  +  M  +  +  M  +  M  M  +  +|             
      Galactocele                          |       X  X                             X  X  X        X                  |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst Epithelial Inclusion            |                X                                                         |             
      Hyperkeratosis                       |                3                                3                        |             
      Necrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |             +                                                            |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Artery, Necrosis, Fibrinoid          |                                                          2               |             
      Brain Stem, Hemorrhage               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  30                                                               
NTP Experiment-Test: 05030-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             PROBENECID                                        Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 15:49:49  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 2| 7| 7| 7| 7| 5|             
                             DAY ON TEST   | 3| 4| 0| 1| 4| 3| 3| 3| 3| 3| 3| 3| 3| 2| 3| 3| 3| 4| 0| 9| 3| 3| 3| 3| 9|             
                                           | 7| 0| 7| 0| 7| 8| 7| 7| 7| 7| 8| 8| 7| 0| 6| 8| 8| 0| 8| 3| 8| 8| 8| 8| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    VEHICLE                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Bronchiectasis                       |             2                                                            |             
      Congestion                           |          2                                2                              |             
      Edema                                |                                                                          |             
      Infiltration Cellular, Histiocyte    |             2                                                            |             
      Inflammation, Chronic Active         |                                                    2                     |             
      Alveolar Epithelium, Hyperplasia     |                                                                   1      |             
      Artery, Necrosis, Fibrinoid          |                                                          3               |             
      Bronchiole, Metaplasia, Squamous     |             1                                                            |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |             +                          +  +                              |             
      Lens, Cataract                       |                                                                          |             
      Retina, Hemorrhage                   |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                        +  +                              |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Nephropathy                          | 2  2  3  2     2  2  1  3  2  1  2  3  2  3  3  2  2  2     2  2  2  2  2|             
      Artery, Inflammation                 |                                                          2               |             
      Cortex, Mineralization               |                   1                                1                     |             
      Papilla, Mineralization              |          1  1  1  1     1  1  1  1  1  1     1  1     1              1  1|             
      Pelvis, Mineralization               |                      1  1                                            1   |             
      Pelvis, Transitional Epithelium,     |                                                                          |             
           Hyperplasia                     |                                     1                                    |             
      Renal Tubule, Hyperplasia            |                                     1           1                        |             
      Renal Tubule, Pigmentation           | 1  1  1  1  1  1  1  1  1  1  1  1  1  1     1  1     1  1  1  1  1  1  1|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calculus Gross Observation           |                                                                          |             
      Calculus Micro Observation Only      |                                                                         X|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  31                                                               
NTP Experiment-Test: 05030-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             PROBENECID                                        Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 15:49:49  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6|            |
                             DAY ON TEST   | 3| 4| 3| 3| 3| 3| 3| 3| 2| 5| 3| 3| 3| 4| 5| 3| 3| 3| 4| 5| 3| 3| 3| 3| 7|            |
                                           | 8| 0| 7| 7| 7| 8| 8| 7| 7| 3| 8| 8| 8| 0| 1| 8| 8| 8| 0| 8| 8| 8| 0| 0| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  47        |
      Parasite                             |                            1                                             |      3  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  M  +  +  A  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  A  +  +  +  +  +  +  +  +     +  +  +  +  +  A  +  +  +  +  +|  47        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  46        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     | X  X     X     X  X     X        X        X  X  X  X  X     X  X  X      |     32     |
      Clear Cell Focus                     |                                                                          |      1  1.0|
      Congestion                           |                                                                          |      1  2.0|
      Fatty Change, Diffuse                |                                           2     1                       2|      8  2.0|
      Fatty Change, Focal                  | 2  1     1  1  1  1     1  2  2        2     2        2     2  2  1  1   |     27  1.6|
      Hepatodiaphragmatic Nodule           |                                     X                                   X|      3     |
      Mixed Cell Focus                     |       X                                                                  |      2     |
      Necrosis                             |                                                                          |      1  2.0|
      Regeneration, Focal                  |                                                                          |      1  2.0|
      Artery, Inflammation, Chronic Active |                                                                          |      1  2.0|
      Bile Duct, Hyperplasia               | 2  2  2  2     2  2  2           2  2  2     2  2  2  2     2  2  2  2   |     35  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |       +              +  +  +                                             |   9        |
      Artery, Necrosis, Fibrinoid          |                                                                          |      2  3.0|
      Fat, Necrosis                        |       4                                                                  |      4  3.8|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acinus, Atrophy                      |                                                             2            |      2  2.0|
      Acinus, Hyperplasia                  |       2        2              2                       2              2   |      7  2.1|
      Artery, Necrosis, Fibrinoid          |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|  49        |
      Acinus, Inflammation, Chronic Active |                                                                          |      1  1.0|
      Artery, Necrosis, Fibrinoid          |                                                                          |      1  2.0|
      Duct, Inflammation, Chronic Active   |                                                                          |      3  1.3|
      Duct, Metaplasia, Squamous           |                         1        1  1                                    |     11  1.2|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acanthosis                           |                                                                   2      |      2  2.0|
      Hyperkeratosis                       |                                                                   3      |      3  2.3|
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  32                                                               
NTP Experiment-Test: 05030-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             PROBENECID                                        Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 15:49:49  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6|            |
                             DAY ON TEST   | 3| 4| 3| 3| 3| 3| 3| 3| 2| 5| 3| 3| 3| 4| 5| 3| 3| 3| 4| 5| 3| 3| 3| 3| 7|            |
                                           | 8| 0| 7| 7| 7| 8| 8| 7| 7| 3| 8| 8| 8| 0| 1| 8| 8| 8| 0| 8| 8| 8| 0| 0| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Necrosis                             |                                                                          |      2  2.5|
      Artery, Necrosis, Fibrinoid          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  49        |
      Artery, Necrosis, Fibrinoid          |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   1        |
      Artery, Necrosis, Fibrinoid          |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       | 2  2  2     2  2  2  2        2     2     2  2  2  2  3  2  2  2  2  2  2|     37  2.0|
      Thrombosis                           |                         X                                                |      1     |
      Artery, Necrosis, Fibrinoid          |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  49        |
      Hemorrhage                           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |                      2                          2  1           2     1   |      9  1.6|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |                               2     2        2                           |      4  2.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  M  +  +  +  +  +|  42        |
      Hyperplasia                          |                                        2                                 |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pars Distalis, Angiectasis           | 2     2                                                     2  2         |      9  2.2|
      Pars Distalis, Hemorrhage            |                                                                          |      1  2.0|
      Pars Distalis, Hyperplasia           |                   2  1                                2  2  3            |     11  2.1|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|  49        |
      C-Cell, Hyperplasia                  |          1                             3                          1      |      7  1.6|
      Capsule, Necrosis, Fibrinoid         |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cyst                                 | X                                                                        |      1     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  33                                                               
NTP Experiment-Test: 05030-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             PROBENECID                                        Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 15:49:49  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6|            |
                             DAY ON TEST   | 3| 4| 3| 3| 3| 3| 3| 3| 2| 5| 3| 3| 3| 4| 5| 3| 3| 3| 4| 5| 3| 3| 3| 3| 7|            |
                                           | 8| 0| 7| 7| 7| 8| 8| 7| 7| 3| 8| 8| 8| 0| 1| 8| 8| 8| 0| 8| 8| 8| 0| 0| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Chronic Active         | 2                                                                        |      2  2.0|
      Necrosis                             |                               2  2                    2                  |      7  2.3|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Chronic Active         |          2                          2                          2         |      5  1.8|
      Artery, Necrosis, Fibrinoid          |                                                                          |      1  2.0|
      Epithelium, Hyperplasia              |                   2                 2                                    |      2  2.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Interstitial Cell, Hyperplasia       |       2           1     1  2  2           1     1     2     1            |     17  1.6|
      Seminiferous Tubule, Atrophy         | 2  2  3  2        2  2  2  2  2  2  2  2  2  2     2  2     2  2  2  2  2|     37  2.2|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   | +     +  +  +  +  +  +        +  +  +  +     +  +  +        +  +         |  31        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Mediastinal, Angiectasis             |                                                                          |      1  2.0|
      Mediastinal, Infiltration Cellular,  |                                                                          |            |
           Histiocyte                      |       3  2              2                                                |      5  2.2|
      Renal, Angiectasis                   |                                                                          |      2  2.0|
      Renal, Depletion Lymphoid            |                                                                          |      1  2.0|
      Renal, Infiltration Cellular,        |                                                                          |            |
          Histiocyte                       |          2                                                              2|      4  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Angiectasis                          |                                                       2                  |      1  2.0|
      Hemorrhage                           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Depletion Lymphoid                   |                                     2                                    |      1  2.0|
      Hematopoietic Cell Proliferation     | 2     2  2     2     2  3     2     2  2  2  2  2     2                 2|     27  2.0|
      Infiltration Cellular, Histiocyte    |                                                                          |      1  3.0|
      Necrosis                             |             2                                                            |      2  2.0|
      Capsule, Fibrosis                    |                                                                          |      1  2.0|
      Capsule, Inflammation, Chronic Active|                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +|  46        |
      Atrophy                              |                                                                      3   |      1  3.0|
      Epithelial Cell, Hyperplasia         |                                  2                                       |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  M  M  +  M  M  +  M  +  +  M  M  M  M  M  M  +  M  +  M  +  +  +|  26        |
      Galactocele                          |       X                                                                  |      7     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  34                                                               
NTP Experiment-Test: 05030-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             PROBENECID                                        Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 15:49:49  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6|            |
                             DAY ON TEST   | 3| 4| 3| 3| 3| 3| 3| 3| 2| 5| 3| 3| 3| 4| 5| 3| 3| 3| 4| 5| 3| 3| 3| 3| 7|            |
                                           | 8| 0| 7| 7| 7| 8| 8| 7| 7| 3| 8| 8| 8| 0| 1| 8| 8| 8| 0| 8| 8| 8| 0| 0| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Cyst Epithelial Inclusion            |                      X                                                   |      2     |
      Hyperkeratosis                       |                      4                                               3   |      4  3.3|
      Necrosis                             |                                                       3                  |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                         +                                                |   2        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Artery, Necrosis, Fibrinoid          |                                                                          |      1  2.0|
      Brain Stem, Hemorrhage               |    1                                                                     |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Bronchiectasis                       |                                                                          |      1  2.0|
      Congestion                           |                            2                                             |      3  2.0|
      Edema                                |                            1                                             |      1  1.0|
      Infiltration Cellular, Histiocyte    |                            2     2                             2         |      4  2.0|
      Inflammation, Chronic Active         |                                                                2         |      2  2.0|
      Alveolar Epithelium, Hyperplasia     |                               2                                          |      2  1.5|
      Artery, Necrosis, Fibrinoid          |                                                                          |      1  3.0|
      Bronchiole, Metaplasia, Squamous     |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|  49        |
      Inflammation, Chronic Active         |    2                                                                     |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                    +                     |   1        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                         +                                         +      |   5        |
      Lens, Cataract                       |                                                                   3      |      1  3.0|
      Retina, Hemorrhage                   |                                                                   3      |      1  3.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                         +                                         +      |   4        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Nephropathy                          | 2  2  3  2  2  2  2  1  2  2  2  2  2  2  1  2  3  2  3  1  2  2  1  2  2|     48  2.0|
      Artery, Inflammation                 |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  35                                                               
NTP Experiment-Test: 05030-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             PROBENECID                                        Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 15:49:49  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6|            |
                             DAY ON TEST   | 3| 4| 3| 3| 3| 3| 3| 3| 2| 5| 3| 3| 3| 4| 5| 3| 3| 3| 4| 5| 3| 3| 3| 3| 7|            |
                                           | 8| 0| 7| 7| 7| 8| 8| 7| 7| 3| 8| 8| 8| 0| 1| 8| 8| 8| 0| 8| 8| 8| 0| 0| 1|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|      A     |
    VEHICLE                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Cortex, Mineralization               |                                                                          |      2  1.0|
      Papilla, Mineralization              |    1  1     1  1  1  1  1  1  1  1  1     1        1     1  1  1  1      |     32  1.0|
      Pelvis, Mineralization               |                         1                                                |      4  1.0|
      Pelvis, Transitional Epithelium,     |                                                                          |            |
           Hyperplasia                     |                                                                          |      1  1.0|
      Renal Tubule, Hyperplasia            |                         1                                                |      3  1.0|
      Renal Tubule, Pigmentation           |    1  1  1     1  1  3  3  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1  1|     46  1.1|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +|  48        |
      Calculus Gross Observation           |          X                                X                              |      2     |
      Calculus Micro Observation Only      |          X                                X                              |      3     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  36                                                               
NTP Experiment-Test: 05030-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             PROBENECID                                        Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 15:49:49  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 6| 7| 7| 7| 7| 2| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 4|             
                             DAY ON TEST   | 3| 3| 2| 6| 6| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 5| 9|             
                                           | 5| 5| 3| 7| 4| 5| 5| 5| 5| 2| 6| 6| 5| 5| 1| 6| 6| 6| 0| 6| 6| 6| 6| 0| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    .1 G/KG                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    LM                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |                            +           +  +              +              +|             
      Necrosis                             |                                                                         3|             
                                            __________________________________________________________________________|             
   Intestine Large                         |       +                    +              +              +              +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |                            A              +              +              +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |                            +              +              +              +|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |       +                    +              +              +              +|             
      Parasite                             |       1                                                                  |             
                                            __________________________________________________________________________|             
   Intestine Small                         |          +                 +              +              +              +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |          +                 +              +              +              +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |                            +              +              +              +|             
      Lymphoid Tissue, Hyperplasia         |                                           2                              |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |          +                 +              +              +              +|             
      Hemorrhage                           |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +     +  +  +  +     +  +     +  +  +  +  +  +  +  +  +  +  +  +     +|             
      Basophilic Focus                     | X  X     X  X     X     X        X     X     X  X  X  X  X  X     X     X|             
      Clear Cell Focus                     | X                                X           X  X                 X      |             
      Congestion                           |                                                       3                  |             
      Cyst                                 |                                                    X                     |             
      Degeneration, Cystic                 |                                                                   1      |             
      Degeneration                         |                                                       1                  |             
      Fatty Change, Diffuse                |                                                          2               |             
      Fatty Change, Focal                  | 2  2                    2        2  1  2     2        1                 2|             
      Hepatodiaphragmatic Nodule           |                            X     X     X                                 |             
      Mixed Cell Focus                     |                                  X                                       |             
      Bile Duct, Hyperplasia               | 2  2        2     2     2        2     2           2        2  2  2     1|             
                                            __________________________________________________________________________|             
   Mesentery                               |                +                                         +               |             
      Fat, Necrosis                        |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |          +     +  +        +  +  +        +  +     +  +  +        +     +|             
      Acinus, Atrophy                      |                            2                                             |             
      Acinus, Hyperplasia                  |                                                                   3      |             
      Artery, Mineralization               |                                              2                           |             
      Artery, Necrosis, Fibrinoid          |                               3                                          |             
                                            __________________________________________________________________________|             
   Pharynx                                 |       +                                                                  |             
      Hyperplasia, Pseudoepitheliomatous   |       3                                                                  |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |          +     +  +        +  +  +        +     +        +              +|             
      Fibrosis                             |                                                 2                        |             
      Hyperplasia                          |                                  2                                       |             
      Duct, Inflammation, Acute            |                               1                                          |             
      Duct, Metaplasia                     |                                                                          |             
      Duct, Metaplasia, Squamous           |                   1           1           1     2                        |             
                                            __________________________________________________________________________|             
   Stomach                                 |                            +              +              +              +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |                            +              +              +              +|             
      Acanthosis                           |                                                                         2|             
      Hyperkeratosis                       |                            2                                            2|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  37                                                               
NTP Experiment-Test: 05030-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             PROBENECID                                        Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 15:49:49  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 6| 7| 7| 7| 7| 2| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 4|             
                             DAY ON TEST   | 3| 3| 2| 6| 6| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 5| 9|             
                                           | 5| 5| 3| 7| 4| 5| 5| 5| 5| 2| 6| 6| 5| 5| 1| 6| 6| 6| 0| 6| 6| 6| 6| 0| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    .1 G/KG                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    LM                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Hyperplasia, Basal Cell              |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Mineralization                       |                                                                          |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |                            +              +              +              +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |                            +              +              +              +|             
      Cardiomyopathy                       |                            2              2              2              2|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Accessory Adrenal Cortical Nodule    |                                                             X            |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                       3                  |             
      Hyperplasia                          |    2                          2                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          | 1  1              2  1                 2        2  2                     |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |          +     +  +        +     +        +  +     +  +  +        +     +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |                   +        +           +  +              +              +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +           +  +  +  +     +              +     +  +  +  +     +     +  +|             
      Pars Distalis, Angiectasis           |                2  2  2                          2  3                 4   |             
      Pars Distalis, Cyst                  |                                           X                              |             
      Pars Distalis, Hyperplasia           | 2           2  2                                                         |             
      Pars Distalis, Pigmentation          |                      2                                                   |             
      Pars Intermedia, Angiectasis         |                                                 2                        |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |                   +        +           +  +              +              +|             
      C-Cell, Hyperplasia                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |             +              +  +     +  +  +        +     +              +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         |       +     +  +     +     +     +                       +              +|             
      Inflammation, Chronic Active         |                2                                                         |             
                                            __________________________________________________________________________|             
   Prostate                                |                            +              +  +           +              +|             
      Inflammation, Chronic Active         |                            2                                             |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |       +  +                 +     +        +  +  +  +  +  +        +  +  +|             
      Concretion                           |                            2                                             |             
                                            __________________________________________________________________________|             
   Testes                                  | +     +  +  +     +     +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Interstitial Cell, Hyperplasia       | 2     2           1     2                 1     1  2                 1  1|             
      Seminiferous Tubule, Atrophy         | 2           3     2     2           2  2        2  2  2     2  3     3   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  38                                                               
NTP Experiment-Test: 05030-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             PROBENECID                                        Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 15:49:49  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 6| 7| 7| 7| 7| 2| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 4|             
                             DAY ON TEST   | 3| 3| 2| 6| 6| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 5| 9|             
                                           | 5| 5| 3| 7| 4| 5| 5| 5| 5| 2| 6| 6| 5| 5| 1| 6| 6| 6| 0| 6| 6| 6| 6| 0| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    .1 G/KG                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    LM                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |                            +              +              +              +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |       +  +  +  +  +        +  +  +     +  +        +     +        +     +|             
      Lumbar, Angiectasis                  |                                  2                                       |             
      Lumbar, Infiltration Cellular,       |                                                                          |             
          Histiocyte                       |                                                                          |             
      Lumbar, Pigmentation                 |                                                                          |             
      Mandibular, Angiectasis              |                               2                                          |             
      Mediastinal, Angiectasis             |                                                                          |             
      Mediastinal, Infiltration Cellular,  |                                                                          |             
           Histiocyte                      |                2                                         2               |             
      Mediastinal, Pigmentation            |       2  2     2                                                         |             
      Pancreatic, Infiltration Cellular,   |                                                                          |             
           Histiocyte                      |                   2                                                      |             
      Pancreatic, Pigmentation             |       2  2        2                                1              2      |             
      Renal, Angiectasis                   |                                  2                                       |             
      Renal, Infiltration Cellular,        |                                                                          |             
          Histiocyte                       |                                                                   3      |             
      Renal, Pigmentation                  |          2                    2                                   2      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |       +  +  +  +           +           +  +        +     +        +     +|             
      Angiectasis                          |             3                                                            |             
      Infiltration Cellular, Histiocyte    |                2                                                  2      |             
      Pigmentation                         |       2  2     2                       2           1                     |             
                                            __________________________________________________________________________|             
   Spleen                                  |          +                 +              +  +           +              +|             
      Congestion                           |                                                                          |             
      Depletion Lymphoid                   |                            2                                             |             
      Fibrosis                             |                                                                          |             
      Hematopoietic Cell Proliferation     |                                           2  2           3               |             
      Hemorrhage                           |                                                                          |             
      Necrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  |       +     +  +           +              +              +              +|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |                            M              M        +     M           +  +|             
      Galactocele                          |                                                    X                     |             
                                            __________________________________________________________________________|             
   Skin                                    |       +     +              +     +        +     +        +              +|             
      Cyst Epithelial Inclusion            |                                                                          |             
      Hyperkeratosis                       |                                                                          |             
      Hyperplasia, Basal Cell              |                                                                          |             
      Pigmentation                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  39                                                               
NTP Experiment-Test: 05030-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             PROBENECID                                        Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 15:49:49  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 6| 7| 7| 7| 7| 2| 7| 7| 7| 7| 6| 7| 7| 7| 7| 6| 7| 7| 7| 6| 4|             
                             DAY ON TEST   | 3| 3| 2| 6| 6| 3| 3| 3| 3| 9| 3| 3| 3| 3| 3| 3| 3| 3| 3| 1| 3| 3| 3| 5| 9|             
                                           | 5| 5| 3| 7| 4| 5| 5| 5| 5| 2| 6| 6| 5| 5| 1| 6| 6| 6| 0| 6| 6| 6| 6| 0| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    .1 G/KG                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    LM                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |                            +              +              +              +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                           +                              |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |                            +              +              +              +|             
      Cerebellum, Hemorrhage               |                                                                         2|             
      Cerebellum, Necrosis                 |                                                                         2|             
      Cerebrum, Hemorrhage                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |             +  +     +     +              +           +  +              +|             
      Congestion                           |             2        2                                1                  |             
      Edema                                |             1              2                                             |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                2                                                         |             
                                            __________________________________________________________________________|             
   Nose                                    |                            +              +              +              +|             
      Congestion                           |                                                                          |             
      Inflammation, Chronic Active         |                                                                         3|             
                                            __________________________________________________________________________|             
   Trachea                                 |             +  +  +  +     +           +  +           +  +              +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     | +                                                        +               |             
                                            __________________________________________________________________________|             
   Eye                                     |          +     +                          +              +               |             
      Hemorrhage                           |                                                                          |             
      Synechia                             |          2                                                               |             
      Lens, Cataract                       |                                           2                              |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |          +     +                          +              +               |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                    X                     |             
      Hydronephrosis                       |                            2                                             |             
      Nephropathy                          | 1  2  2  3     2  2  2  1     3  2  2  2  1  2  3  2  3  1  1  2  1  1  1|             
      Cortex, Mineralization               | 2  1                       2  1                 1     1                  |             
      Papilla, Mineralization              | 1        1  1     1  1        1  1              1     1  1     1  1      |             
      Pelvis, Mineralization               | 1              1     1           1        1        1     1               |             
      Renal Tubule, Degeneration           |                                                          1               |             
      Renal Tubule, Pigmentation           | 2  1  2  2     2  2  2  2     2  2  2  2  2  2  2  2  1  1  2  2  1  1  1|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |                +           +              +  +           +              +|             
      Calculus Gross Observation           |                X                                                         |             
      Calculus Micro Observation Only      |                X                                                         |             
      Hemorrhage                           |                            3                                             |             
      Necrosis                             |                            3                                             |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  40                                                               
NTP Experiment-Test: 05030-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             PROBENECID                                        Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 15:49:49  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 5| 4| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6|            |
                             DAY ON TEST   | 3| 5| 3| 1| 3| 3| 3| 3| 3| 0| 3| 3| 3| 8| 6| 3| 3| 3| 9| 9| 3| 3| 3| 3| 7|            |
                                           | 7| 1| 6| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 2| 2| 7| 7| 7| 9| 4| 7| 7| 7| 0| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
    .1 G/KG                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    LM                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |    +     +                 +           +  +  +                          +|  12        |
      Necrosis                             |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large                         |          +                 +           +  +                              |   9        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |          +                 +           +  +                              |   7        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |          +                 +           +  +                              |   8        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |          +                 +           +  +                              |   9        |
      Parasite                             |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         |          +                 +           +  +                              |   9        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |          +                 +           +  +                              |   9        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |          +                 +           +  +                              |   8        |
      Lymphoid Tissue, Hyperplasia         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |          +                 M           +  +                              |   8        |
      Hemorrhage                           |          2                                                               |      1  2.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +     +  +  +  +     +  +        +     +  +  +|  41        |
      Basophilic Focus                     |    X  X  X     X     X  X              X           X        X     X  X   |     27     |
      Clear Cell Focus                     |             X  X        X                          X        X     X      |     11     |
      Congestion                           |                                                                          |      1  3.0|
      Cyst                                 |                                                                          |      1     |
      Degeneration, Cystic                 |                                                                          |      1  1.0|
      Degeneration                         |                                                                          |      1  1.0|
      Fatty Change, Diffuse                |    2     2                 2                                             |      4  2.0|
      Fatty Change, Focal                  |       1              2                 1  2                       1      |     14  1.6|
      Hepatodiaphragmatic Nodule           |       X           X                    X                                 |      6     |
      Mixed Cell Focus                     |    X                                                                     |      2     |
      Bile Duct, Hyperplasia               | 2     2  2  2  2  2     2  2     2     2  2        2              2      |     25  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                               +                       +                  |   4        |
      Fat, Necrosis                        |                                                       3                  |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                |          +                 +  +        +  +     +     +                  |  20        |
      Acinus, Atrophy                      |                                                                          |      1  2.0|
      Acinus, Hyperplasia                  |                            3                                             |      2  3.0|
      Artery, Mineralization               |                                                                          |      1  2.0|
      Artery, Necrosis, Fibrinoid          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pharynx                                 |                                                                          |   1        |
      Hyperplasia, Pseudoepitheliomatous   |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |          +           +     +           +  +                          +   |  16        |
      Fibrosis                             |                                                                          |      1  2.0|
      Hyperplasia                          |                                                                          |      1  2.0|
      Duct, Inflammation, Acute            |                                                                          |      1  1.0|
      Duct, Metaplasia                     |                                                                      2   |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  41                                                               
NTP Experiment-Test: 05030-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             PROBENECID                                        Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 15:49:49  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 5| 4| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6|            |
                             DAY ON TEST   | 3| 5| 3| 1| 3| 3| 3| 3| 3| 0| 3| 3| 3| 8| 6| 3| 3| 3| 9| 9| 3| 3| 3| 3| 7|            |
                                           | 7| 1| 6| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 2| 2| 7| 7| 7| 9| 4| 7| 7| 7| 0| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
    .1 G/KG                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    LM                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Duct, Metaplasia, Squamous           |                      1                                                   |      5  1.2|
                                            __________________________________________________________________________|____________|
   Stomach                                 |          +                 +  +  +     +  +           +  +               |  12        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |          +                 +  +  +     +  +           +  +               |  12        |
      Acanthosis                           |                                                       3  2               |      3  2.3|
      Hyperkeratosis                       |                                                          2               |      3  2.0|
      Hyperplasia, Basal Cell              |                            1                                             |      1  1.0|
      Inflammation, Chronic Active         |                                                       2                  |      1  2.0|
      Mineralization                       |                                                       2                  |      1  2.0|
      Necrosis                             |                                                          2               |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |          +                 +     +     +  +           +  +               |  11        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   |          +                 +           +  +                              |   8        |
      Cardiomyopathy                       |          2                 2           2  2                              |      8  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Accessory Adrenal Cortical Nodule    |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hemorrhage                           |                                                                          |      1  3.0|
      Hyperplasia                          | 2                                                                        |      3  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |                2     2     2        2     2           1           2  2   |     15  1.7|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |          +                 +           +  +     +     +  +               |  19        |
      Hyperplasia                          |                                                          2               |      1  2.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |          +                 M           +  +  +                          +|  11        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |    +     +  +        +     +           +  +     +  +  +     +     +      |  26        |
      Pars Distalis, Angiectasis           |             3        2                          3           3     2      |     11  2.5|
      Pars Distalis, Cyst                  |                                                                          |      1     |
      Pars Distalis, Hyperplasia           |                                                    1  2           2      |      6  1.8|
      Pars Distalis, Pigmentation          |                                                                          |      1  2.0|
      Pars Intermedia, Angiectasis         |                                           2                              |      2  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |          +                 +           +  +  +                          +|  12        |
      C-Cell, Hyperplasia                  |                                        2                                 |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  42                                                               
NTP Experiment-Test: 05030-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             PROBENECID                                        Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 15:49:49  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 5| 4| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6|            |
                             DAY ON TEST   | 3| 5| 3| 1| 3| 3| 3| 3| 3| 0| 3| 3| 3| 8| 6| 3| 3| 3| 9| 9| 3| 3| 3| 3| 7|            |
                                           | 7| 1| 6| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 2| 2| 7| 7| 7| 9| 4| 7| 7| 7| 0| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
    .1 G/KG                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    LM                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +        +     +  +  +  +  +  +  +  +  +  +        +     +     +  +  +   |  26        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +        +           +     +           +  +  +                           |  15        |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Prostate                                |          +                 +           +  +           +                  |  10        |
      Inflammation, Chronic Active         |                                                       2                  |      2  2.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +     +     +     +  +  +  +  +     +  +  +  +  +     +     +     +   |  30        |
      Concretion                           |                                        2     3                           |      3  2.3|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +     +  +  +  +  +  +  +  +  +  +     +  +     +  +  +  +  +  +|  44        |
      Interstitial Cell, Hyperplasia       |       1  1     1  1  2  1  2           2                       1  2  1   |     20  1.4|
      Seminiferous Tubule, Atrophy         | 2     3        2     2  2     3     2           3  3           3  2  2  3|     25  2.4|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   |                               +                                          |   1        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |          +                 +           +  +                              |   8        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +        +           +     +  +     +  +  +     +     +     +        +  +|  27        |
      Lumbar, Angiectasis                  |                                                                          |      1  2.0|
      Lumbar, Infiltration Cellular,       |                                                                          |            |
          Histiocyte                       |                                                                         2|      1  2.0|
      Lumbar, Pigmentation                 |                                                                         2|      1  2.0|
      Mandibular, Angiectasis              |                                                                          |      1  2.0|
      Mediastinal, Angiectasis             |                      2                                                   |      1  2.0|
      Mediastinal, Infiltration Cellular,  |                                                                          |            |
           Histiocyte                      |                                                                          |      2  2.0|
      Mediastinal, Pigmentation            |                                     2                                    |      4  2.0|
      Pancreatic, Infiltration Cellular,   |                                                                          |            |
           Histiocyte                      |                                                 2                        |      2  2.0|
      Pancreatic, Pigmentation             |                                                 2                        |      6  1.8|
      Renal, Angiectasis                   |                                                                          |      1  2.0|
      Renal, Infiltration Cellular,        |                                                                          |            |
          Histiocyte                       |                                                                      2   |      2  2.5|
      Renal, Pigmentation                  |                                                       2                  |      4  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +        +                 +  +        +  +           +     +        +   |  20        |
      Angiectasis                          | 3                                                                        |      2  3.0|
      Infiltration Cellular, Histiocyte    |                                                             2        2   |      4  2.0|
      Pigmentation                         |                               1                       2     2        2   |      9  1.8|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +        +  +     +        +  +  +     +  +  +        +           +     +|  19        |
      Congestion                           |                                                                   3      |      1  3.0|
      Depletion Lymphoid                   |                                                                          |      1  2.0|
      Fibrosis                             | 2                                                                        |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  43                                                               
NTP Experiment-Test: 05030-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             PROBENECID                                        Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 15:49:49  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 5| 4| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6|            |
                             DAY ON TEST   | 3| 5| 3| 1| 3| 3| 3| 3| 3| 0| 3| 3| 3| 8| 6| 3| 3| 3| 9| 9| 3| 3| 3| 3| 7|            |
                                           | 7| 1| 6| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 2| 2| 7| 7| 7| 9| 4| 7| 7| 7| 0| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
    .1 G/KG                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    LM                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Hematopoietic Cell Proliferation     |          2        2           2  2           2                    2      |      9  2.1|
      Hemorrhage                           | 2                                                                        |      1  2.0|
      Necrosis                             |                                                                         3|      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  |          +           +     +           +  +           +  +               |  14        |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |          +           +     M           +  +           +     +            |   9        |
      Galactocele                          |                                           X           X                  |      3     |
                                            __________________________________________________________________________|____________|
   Skin                                    | +        +           +  +  +  +  +     +  +              +  +  +         |  20        |
      Cyst Epithelial Inclusion            |                                  X                                       |      1     |
      Hyperkeratosis                       | 3                                3                       3               |      3  3.0|
      Hyperplasia, Basal Cell              |                                  1                                       |      1  1.0|
      Pigmentation                         |                               2                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |          +                 +           +  +                              |   8        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |          +                 +           +  +                              |   8        |
      Cerebellum, Hemorrhage               |                                                                          |      1  2.0|
      Cerebellum, Necrosis                 |                                                                          |      1  2.0|
      Cerebrum, Hemorrhage                 |                            3                                             |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +     +     +  +        +     +     +  +           +                  |  18        |
      Congestion                           |    4                                                                     |      4  2.3|
      Edema                                |                                                                          |      2  1.5|
      Hemorrhage                           |    2           1                 2                                       |      3  1.7|
      Inflammation, Acute                  |                                  3                                       |      1  3.0|
      Alveolar Epithelium, Hyperplasia     |                2                          2                              |      3  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    |    +     +                 +           +  +                              |   9        |
      Congestion                           |    2                                                                     |      1  2.0|
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +        +     +  +        +           +  +           +                  |  18        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                           +                              |   3        |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                     +  +  +           +                  |   8        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  44                                                               
NTP Experiment-Test: 05030-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             PROBENECID                                        Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 15:49:49  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 6| 7| 5| 7| 7| 7| 7| 7| 5| 7| 7| 7| 5| 4| 7| 7| 7| 6| 6| 7| 7| 7| 7| 6|            |
                             DAY ON TEST   | 3| 5| 3| 1| 3| 3| 3| 3| 3| 0| 3| 3| 3| 8| 6| 3| 3| 3| 9| 9| 3| 3| 3| 3| 7|            |
                                           | 7| 1| 6| 7| 7| 7| 7| 7| 7| 3| 7| 7| 7| 2| 2| 7| 7| 7| 9| 4| 7| 7| 7| 0| 2|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|      A     |
    .1 G/KG                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
    LM                                     | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Hemorrhage                           |                                     2                                    |      1  2.0|
      Synechia                             |                                                                          |      1  2.0|
      Lens, Cataract                       |                                     2                 3                  |      3  2.3|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                     +  +              +                  |   7        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cyst                                 |                                                                          |      1     |
      Hydronephrosis                       |                                                                          |      1  2.0|
      Nephropathy                          | 1  1  1  1  2  2  3  2  1  2  1  2  2  1  1  2  2  2  2  1  2  2  2  3  2|     48  1.8|
      Cortex, Mineralization               |                1  1                             1                        |      9  1.2|
      Papilla, Mineralization              |       1  1  1  1  1        1  1  1  1  1  1     1  1  1     1  1  1  1  1|     31  1.0|
      Pelvis, Mineralization               |          1              1        1              1           1            |     12  1.0|
      Renal Tubule, Degeneration           |                                                                          |      1  1.0|
      Renal Tubule, Pigmentation           | 1     2  1  2  2  2  1  2  1  3  2  2     1  2  2  2  2  3  3  2  2  2  2|     46  1.8|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |          +                 +           +  +                              |  10        |
      Calculus Gross Observation           |                            X                                             |      2     |
      Calculus Micro Observation Only      |                            X                                             |      2     |
      Hemorrhage                           |                                                                          |      1  3.0|
      Necrosis                             |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  45                                                               
NTP Experiment-Test: 05030-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             PROBENECID                                        Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 15:49:49  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 5| 7| 7| 7| 6| 4| 7| 7| 6| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4|             
                             DAY ON TEST   | 3| 3| 0| 9| 8| 3| 3| 2| 1| 5| 3| 2| 6| 0| 9| 3| 3| 3| 0| 0| 3| 1| 0| 0| 9|             
                                           | 0| 0| 8| 5| 8| 0| 0| 7| 1| 7| 0| 3| 6| 0| 1| 5| 5| 0| 6| 3| 0| 3| 4| 4| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    .4 G/KG                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     HM                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                                                                         2|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                2         |             
      Lymphoid Nodule, Hyperplasia         |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite                             | 1                       1                    2           1               |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite                             |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Lymphoid Nodule, Hyperplasia         |          3                                                               |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                2         |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     | X              X  X  X        X  X     X     X  X  X  X  X  X  X  X  X   |             
      Clear Cell Focus                     |    X                                                                     |             
      Eosinophilic Focus                   |                                                                          |             
      Fatty Change, Diffuse                |                                                                2         |             
      Fatty Change, Focal                  |                   1                          2     1  1  1        1     2|             
      Focal Cellular Change                |                      X  X                                                |             
      Hepatodiaphragmatic Nodule           |                   X                                X                     |             
      Mixed Cell Focus                     | X                                                                        |             
      Necrosis                             |       2                                                              1   |             
      Bile Duct, Hyperplasia               | 2  2  2  2  2  2  2  2  2     2  2  2     2  2     2  2  2  2        2   |             
                                            __________________________________________________________________________|             
   Mesentery                               |    +  +                       +                                +     +   |             
      Fat, Inflammation, Chronic Active    |                               1                                2         |             
      Fat, Necrosis                        |    3                                                                     |             
      Fat, Pigmentation                    |                               3                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acinus, Atrophy                      |                                                                      2   |             
      Acinus, Hyperplasia                  |                   3                                      2               |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Duct, Inflammation, Chronic Active   |    1                                                                     |             
      Duct, Metaplasia                     |                                                                          |             
      Duct, Metaplasia, Squamous           |    2                 1  1     1        1                             1   |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                  2                             1         |             
      Hyperkeratosis                       |                                  2                                       |             
      Inflammation, Chronic Active         |                                                                          |             
      Necrosis                             |                                                                         1|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  46                                                               
NTP Experiment-Test: 05030-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             PROBENECID                                        Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 15:49:49  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 5| 7| 7| 7| 6| 4| 7| 7| 6| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4|             
                             DAY ON TEST   | 3| 3| 0| 9| 8| 3| 3| 2| 1| 5| 3| 2| 6| 0| 9| 3| 3| 3| 0| 0| 3| 1| 0| 0| 9|             
                                           | 0| 0| 8| 5| 8| 0| 0| 7| 1| 7| 0| 3| 6| 0| 1| 5| 5| 0| 6| 3| 0| 3| 4| 4| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    .4 G/KG                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     HM                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                           2                              |             
      Mineralization                       |                                                          2               |             
      Necrosis                             |                                                                1         |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cardiomyopathy                       |    2  2  2  2  2  3  2  2  2     3  3  2  2  2  2  2  2  2  2  2  2  2   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Vacuolization Cytoplasmic            |                                                                3         |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                1  2  2                                2     2  2  1      |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                   2      |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  M  M  +  +  +  +  +  +  +  +  +  M  +  M  +  +  +  +  +  +  +  +  M|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                               2  3                                2      |             
      Pars Distalis, Hemorrhage            |                            4                                             |             
      Pars Distalis, Hyperplasia           |                2  2     2           2        2                           |             
      Pars Distalis, Necrosis              |                            3                                             |             
      Pars Intermedia, Hyperplasia         |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      C-Cell, Hyperplasia                  |       2        1                                                         |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +|             
      Fibrosis                             |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Spermatocele                         |                                                                   2      |             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                            3                                             |             
      Necrosis                             |                2  2              2  3                 3                  |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |             1                 2        2                                 |             
      Epithelium, Hyperplasia              |             2                 1                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  47                                                               
NTP Experiment-Test: 05030-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             PROBENECID                                        Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 15:49:49  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 5| 7| 7| 7| 6| 4| 7| 7| 6| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4|             
                             DAY ON TEST   | 3| 3| 0| 9| 8| 3| 3| 2| 1| 5| 3| 2| 6| 0| 9| 3| 3| 3| 0| 0| 3| 1| 0| 0| 9|             
                                           | 0| 0| 8| 5| 8| 0| 0| 7| 1| 7| 0| 3| 6| 0| 1| 5| 5| 0| 6| 3| 0| 3| 4| 4| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    .4 G/KG                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     HM                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Atrophy                              |                                              3                           |             
      Congestion                           |                            1                                             |             
      Interstitial Cell, Hyperplasia       | 2  1  1     2     2     2     2  2     2  1           2           1  1  1|             
      Seminiferous Tubule, Atrophy         | 2  2  2        2  2  2        2  3  2              2  2        2  3  2   |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood                                   | +  +           +  +           +              +  +  +        +            |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Iliac, Infiltration Cellular,        |                                                                          |             
          Histiocyte                       |             2                                                            |             
      Lumbar, Hematopoietic Cell           |                                                                          |             
          Proliferation                    |                      2                                                   |             
      Lumbar, Hemorrhage                   |             2                                                            |             
      Lumbar, Infiltration Cellular,       |                                                                          |             
          Histiocyte                       |                                                    2                     |             
      Mandibular, Necrosis                 |                                                                          |             
      Mediastinal, Angiectasis             |                                  2                       2     2         |             
      Mediastinal, Depletion Lymphoid      |                                                                          |             
      Mediastinal, Infiltration Cellular,  |                                                                          |             
           Histiocyte                      |       3                                                              2   |             
      Pancreatic, Infiltration Cellular,   |                                                                          |             
           Histiocyte                      |                                                       2                  |             
      Renal, Angiectasis                   |                                  2                                       |             
      Renal, Hemorrhage                    |             1                                                            |             
      Renal, Infiltration Cellular,        |                                                                          |             
          Histiocyte                       |       2        2     2           2                 2        3  3     3   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|             
      Angiectasis                          |                                  3           2           2               |             
      Depletion Lymphoid                   |                                                       2                  |             
      Infiltration Cellular, Mast Cell     |                            2                                             |             
      Infiltration Cellular, Histiocyte    | 2  2  2  2  2  2                    2           2  2     2  1            |             
      Renal, Angiectasis                   |                                                                3         |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Depletion Lymphoid                   |                                                          2     3         |             
      Fibrosis                             |                                                             2            |             
      Hematopoietic Cell Proliferation     | 2  2  3  2  2  2  2  3  2  1  2  3     3     2  2  2  2  1           3  2|             
      Hemorrhage                           |                                                                          |             
      Infiltration Cellular, Histiocyte    |                            2                                   3         |             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Depletion Lymphoid                   |                                                                          |             
      Epithelial Cell, Hyperplasia         |                                                    2                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  48                                                               
NTP Experiment-Test: 05030-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             PROBENECID                                        Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 15:49:49  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 5| 7| 7| 7| 6| 4| 7| 7| 6| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4|             
                             DAY ON TEST   | 3| 3| 0| 9| 8| 3| 3| 2| 1| 5| 3| 2| 6| 0| 9| 3| 3| 3| 0| 0| 3| 1| 0| 0| 9|             
                                           | 0| 0| 8| 5| 8| 0| 0| 7| 1| 7| 0| 3| 6| 0| 1| 5| 5| 0| 6| 3| 0| 3| 4| 4| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    .4 G/KG                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     HM                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  M  +  M  M  +  +  M  M  +  +  +  +  M  M  M  +  +  M  +  M  +  M  +|             
      Galactocele                          |                               X  X                                X      |             
      Acinus, Hyperplasia                  |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                                          |             
      Cyst Epithelial Inclusion            |                                                             X            |             
      Fibrosis                             |                                                                          |             
      Hyperkeratosis                       |                                  3                          3     4      |             
      Hyperplasia, Basal Cell              |                                                             1            |             
      Inflammation, Acute                  |                                                                          |             
      Necrosis                             |                                        2                                 |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |       +                                                        +        +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cerebellum, Hemorrhage               |                                                                          |             
      Cerebrum, Hemorrhage                 |                            1                                             |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atelectasis                          |                                                                          |             
      Congestion                           |                         2  2                                             |             
      Edema                                |          2                                                              2|             
      Hemorrhage                           |          2                                                               |             
      Infiltration Cellular, Histiocyte    |                1                                                        2|             
      Inflammation, Chronic Active         |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                                 1                        |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         | 2                                               2              3         |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |          3                                                               |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |             +                             +                              |             
      Hemorrhage                           |             2                                                            |             
      Necrosis                             |             3                                                            |             
                                            __________________________________________________________________________|             
   Eye                                     |                +  +     +  +              +           +           +  +   |             
      Synechia                             |                   2     3                                                |             
      Lens, Cataract                       |                                                                   2  2   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  49                                                               
NTP Experiment-Test: 05030-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             PROBENECID                                        Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 15:49:49  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 6| 5| 7| 7| 7| 6| 4| 7| 7| 6| 6| 4| 7| 7| 7| 7| 7| 7| 7| 7| 7| 4|             
                             DAY ON TEST   | 3| 3| 0| 9| 8| 3| 3| 2| 1| 5| 3| 2| 6| 0| 9| 3| 3| 3| 0| 0| 3| 1| 0| 0| 9|             
                                           | 0| 0| 8| 5| 8| 0| 0| 7| 1| 7| 0| 3| 6| 0| 1| 5| 5| 0| 6| 3| 0| 3| 4| 4| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    .4 G/KG                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     HM                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Retina, Atrophy                      |                   2     3                                            2   |             
      Sclera, Pigmentation                 |                         1                                                |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |             +           +                             +                  |             
      Hyperplasia                          |                         1                                                |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                         2|             
      Cyst                                 |       X                                                                  |             
      Nephropathy                          | 2  2  2  2  2  3  2  1  1     3  3     1  2  2  2  2  1  2  1  2  2  1  1|             
      Cortex, Mineralization               | 1                                                                        |             
      Papilla, Mineralization              | 1  1     1     1  1  1  2  1  1  1  1        1  1        1  1  1  1  1  1|             
      Pelvis, Mineralization               |    1  1              1        1  1                 1  1        1         |             
      Renal Tubule, Mineralization         |                   1                                                      |             
      Renal Tubule, Pigmentation           | 1  2  3  1  1  1     2  1  1  2  2  1  1  1  1  1  2  1  1  2  2  2  3  1|             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calculus Micro Observation Only      |                            X                                             |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  50                                                               
NTP Experiment-Test: 05030-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             PROBENECID                                        Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 15:49:49  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 3| 7| 7| 6| 6| 3| 5| 7| 6| 5| 5|            |
                             DAY ON TEST   | 3| 3| 3| 3| 7| 3| 3| 3| 3| 9| 3| 3| 3| 0| 3| 3| 0| 6| 5| 7| 8| 3| 7| 6| 1|            |
                                           | 5| 5| 5| 5| 4| 5| 5| 5| 5| 0| 5| 5| 0| 0| 6| 5| 7| 0| 2| 2| 0| 5| 0| 2| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      A     |
    .4 G/KG                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     HM                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M|  48        |
      Hyperkeratosis                       |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Lymphoid Nodule, Hyperplasia         |                                                                      2   |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Parasite                             | 1                                                              2         |      6  1.3|
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Parasite                             |                   2                                                      |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  M  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  47        |
      Lymphoid Nodule, Hyperplasia         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A|  47        |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Basophilic Focus                     | X     X  X     X  X  X  X     X  X  X  X     X  X  X  X        X  X  X   |     34     |
      Clear Cell Focus                     |                                                                          |      1     |
      Eosinophilic Focus                   | 1                                                                        |      1  1.0|
      Fatty Change, Diffuse                |                                                                          |      1  2.0|
      Fatty Change, Focal                  |                      2  1        1     2           1     1              1|     14  1.3|
      Focal Cellular Change                |                                                                          |      2     |
      Hepatodiaphragmatic Nodule           |                                                                      X   |      3     |
      Mixed Cell Focus                     |                                                                          |      1     |
      Necrosis                             |                                                                          |      2  1.5|
      Bile Duct, Hyperplasia               | 2  2     2     2  2  2        2  2  2  2     2  2  2        2  2  2  2  2|     37  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   5        |
      Fat, Inflammation, Chronic Active    |                                                                          |      2  1.5|
      Fat, Necrosis                        |                                                                          |      1  3.0|
      Fat, Pigmentation                    |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Acinus, Atrophy                      |                                                                          |      1  2.0|
      Acinus, Hyperplasia                  |       2  2                       2                             2         |      6  2.2|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Duct, Inflammation, Chronic Active   |                                                                          |      1  1.0|
      Duct, Metaplasia                     |                         1                                                |      1  1.0|
      Duct, Metaplasia, Squamous           | 1                 1                             1                 2      |     10  1.2|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  51                                                               
NTP Experiment-Test: 05030-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             PROBENECID                                        Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 15:49:49  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 3| 7| 7| 6| 6| 3| 5| 7| 6| 5| 5|            |
                             DAY ON TEST   | 3| 3| 3| 3| 7| 3| 3| 3| 3| 9| 3| 3| 3| 0| 3| 3| 0| 6| 5| 7| 8| 3| 7| 6| 1|            |
                                           | 5| 5| 5| 5| 4| 5| 5| 5| 5| 0| 5| 5| 0| 0| 6| 5| 7| 0| 2| 2| 0| 5| 0| 2| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      A     |
    .4 G/KG                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     HM                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Acanthosis                           |    2                                   2              3                 1|      6  1.8|
      Hyperkeratosis                       |    1                                   2              3                 1|      5  1.8|
      Inflammation, Chronic Active         |    2                                                                     |      1  2.0|
      Necrosis                             |                                                                      2   |      2  1.5|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |                                                                          |      1  2.0|
      Mineralization                       |                                                                          |      1  2.0|
      Necrosis                             |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cardiomyopathy                       | 2  2        2  2  2  2  2  2  2  1  2  2     3  2  2  2  2  2  3  2  2  2|     44  2.1|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Vacuolization Cytoplasmic            |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Hyperplasia                          |       2              1           2  1           1           1        2   |     14  1.6|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  M  +  +  +  M  +  +  +  +  +|  42        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Pars Distalis, Angiectasis           |             2  2  2                 4           2  2                     |      9  2.3|
      Pars Distalis, Hemorrhage            |                                                                          |      1  4.0|
      Pars Distalis, Hyperplasia           |       2                                                        2         |      7  2.0|
      Pars Distalis, Necrosis              |                                                                          |      1  3.0|
      Pars Intermedia, Hyperplasia         |                2                                                         |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Hemorrhage                           |                                                       2                  |      1  2.0|
      C-Cell, Hyperplasia                  |    2  1  3                    2  1  1  1              2                  |     10  1.6|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  48        |
      Fibrosis                             |                                     2                                    |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  52                                                               
NTP Experiment-Test: 05030-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             PROBENECID                                        Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 15:49:49  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 3| 7| 7| 6| 6| 3| 5| 7| 6| 5| 5|            |
                             DAY ON TEST   | 3| 3| 3| 3| 7| 3| 3| 3| 3| 9| 3| 3| 3| 0| 3| 3| 0| 6| 5| 7| 8| 3| 7| 6| 1|            |
                                           | 5| 5| 5| 5| 4| 5| 5| 5| 5| 0| 5| 5| 0| 0| 6| 5| 7| 0| 2| 2| 0| 5| 0| 2| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      A     |
    .4 G/KG                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     HM                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Chronic Active         |                                     2                                    |      1  2.0|
      Spermatocele                         |                                     X                                    |      2  2.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
      Necrosis                             |                                                    3           2         |      7  2.4|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Inflammation, Chronic Active         |                                                                          |      3  1.7|
      Epithelium, Hyperplasia              |                                                                   1      |      3  1.3|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atrophy                              |                                                                          |      1  3.0|
      Congestion                           |                                                                          |      1  1.0|
      Interstitial Cell, Hyperplasia       |    2  2                 2           2  2  2        2     1  2     1  2  2|     26  1.7|
      Seminiferous Tubule, Atrophy         | 2  2  2  2     4  2  3  2        2  3  2     2  2  2  2        2  2  2   |     32  2.2|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood                                   | +  +  +  +     +  +  +        +  +  +        +                 +         |  21        |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|  48        |
      Iliac, Infiltration Cellular,        |                                                                          |            |
          Histiocyte                       |                                                                          |      1  2.0|
      Lumbar, Hematopoietic Cell           |                                                                          |            |
          Proliferation                    |                                                                          |      1  2.0|
      Lumbar, Hemorrhage                   |                                        2                                 |      2  2.0|
      Lumbar, Infiltration Cellular,       |                                                                          |            |
          Histiocyte                       |                                        2                                 |      2  2.0|
      Mandibular, Necrosis                 |                                              2                           |      1  2.0|
      Mediastinal, Angiectasis             |                                              2                           |      4  2.0|
      Mediastinal, Depletion Lymphoid      |                                                                         2|      1  2.0|
      Mediastinal, Infiltration Cellular,  |                                                                          |            |
           Histiocyte                      |                                  2           2                           |      4  2.3|
      Pancreatic, Infiltration Cellular,   |                                                                          |            |
           Histiocyte                      |                                                                          |      1  2.0|
      Renal, Angiectasis                   |                                        3                                 |      2  2.5|
      Renal, Hemorrhage                    |                                                                          |      1  1.0|
      Renal, Infiltration Cellular,        |                                                                          |            |
          Histiocyte                       |                                        3           2                    1|     11  2.3|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +|  47        |
      Angiectasis                          |                   2                             2                        |      5  2.2|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  53                                                               
NTP Experiment-Test: 05030-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             PROBENECID                                        Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 15:49:49  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 3| 7| 7| 6| 6| 3| 5| 7| 6| 5| 5|            |
                             DAY ON TEST   | 3| 3| 3| 3| 7| 3| 3| 3| 3| 9| 3| 3| 3| 0| 3| 3| 0| 6| 5| 7| 8| 3| 7| 6| 1|            |
                                           | 5| 5| 5| 5| 4| 5| 5| 5| 5| 0| 5| 5| 0| 0| 6| 5| 7| 0| 2| 2| 0| 5| 0| 2| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      A     |
    .4 G/KG                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     HM                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Depletion Lymphoid                   |                                                                         2|      2  2.0|
      Infiltration Cellular, Mast Cell     |                                                                          |      1  2.0|
      Infiltration Cellular, Histiocyte    |          2                       2     2     2  2  1              2      |     18  1.9|
      Renal, Angiectasis                   |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Depletion Lymphoid                   |                                                                          |      2  2.5|
      Fibrosis                             |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     | 2           2  2  2  1  2     2  2  2  3     2     2     2  2  1  2  3  2|     38  2.1|
      Hemorrhage                           |                                                                      2   |      1  2.0|
      Infiltration Cellular, Histiocyte    |                                           2                              |      3  2.3|
      Pigmentation                         |                         2                                                |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  M  +  M  +|  46        |
      Atrophy                              |                                           3                              |      1  3.0|
      Depletion Lymphoid                   |                                                                         4|      1  4.0|
      Epithelial Cell, Hyperplasia         |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  +  +  M  +  M  M  M  +  M  M  M  +  +  M  +  +  +  M  +  +  +  M  +  M|  27        |
      Galactocele                          |             X                       X                                    |      5     |
      Acinus, Hyperplasia                  |                                     3                                    |      1  3.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Abscess                              |                                                                4         |      1  4.0|
      Cyst Epithelial Inclusion            |                                                                          |      1     |
      Fibrosis                             |                                              2                           |      1  2.0|
      Hyperkeratosis                       |                                              2                           |      4  3.0|
      Hyperplasia, Basal Cell              |                                                                          |      1  1.0|
      Inflammation, Acute                  |                                              4                           |      1  4.0|
      Necrosis                             |                                        3     3                           |      3  2.7|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   3        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Cerebellum, Hemorrhage               |                                  1                                       |      1  1.0|
      Cerebrum, Hemorrhage                 |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  54                                                               
NTP Experiment-Test: 05030-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                             PROBENECID                                        Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 15:49:49  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 5| 7| 7| 7| 7| 6| 7| 7| 7| 7| 3| 7| 7| 6| 6| 3| 5| 7| 6| 5| 5|            |
                             DAY ON TEST   | 3| 3| 3| 3| 7| 3| 3| 3| 3| 9| 3| 3| 3| 0| 3| 3| 0| 6| 5| 7| 8| 3| 7| 6| 1|            |
                                           | 5| 5| 5| 5| 4| 5| 5| 5| 5| 0| 5| 5| 0| 0| 6| 5| 7| 0| 2| 2| 0| 5| 0| 2| 3|      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|      A     |
    .4 G/KG                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|      L     |
     HM                                    | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Atelectasis                          |                                  2                                       |      1  2.0|
      Congestion                           |                                  2                             2         |      4  2.0|
      Edema                                |                                                       2                  |      3  2.0|
      Hemorrhage                           |                               1                 1     1           1     1|      6  1.2|
      Infiltration Cellular, Histiocyte    |          1  1                                            1               |      5  1.2|
      Inflammation, Chronic Active         |                                           1                              |      1  1.0|
      Alveolar Epithelium, Hyperplasia     |                                                 1                        |      2  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  49        |
      Inflammation, Chronic Active         |                2  2              3                    2                  |      7  2.3|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Erosion                              |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                              +                           |   3        |
      Hemorrhage                           |                                                                          |      1  2.0|
      Necrosis                             |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                          +           +  +|  11        |
      Synechia                             |                                                                          |      2  2.5|
      Lens, Cataract                       |                                                                      2   |      3  2.0|
      Retina, Atrophy                      |                                                                          |      3  2.3|
      Sclera, Pigmentation                 |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                      +   |   4        |
      Hyperplasia                          |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|  50        |
      Congestion                           |                                           2                              |      2  2.0|
      Cyst                                 |                                                                          |      1     |
      Nephropathy                          | 2  2  2  2  3  2  3  2  2  2  2  2  2  3     3  1  2  2  1  1  2  2  1  1|     47  1.9|
      Cortex, Mineralization               |                                                    1                     |      2  1.0|
      Papilla, Mineralization              | 1  1        2     1  1     2  1  1  1           1  1        1  1  1  1  1|     35  1.1|
      Pelvis, Mineralization               | 1                                   1              1     1     1         |     13  1.0|
      Renal Tubule, Mineralization         |                   1  1                                                   |      3  1.0|
      Renal Tubule, Pigmentation           | 2  2  1  2  1  2        1     2  1  1  1  1  1  1  1  1  1  1  2  1  1  1|     46  1.4|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|  47        |
      Calculus Micro Observation Only      |                                                                          |      1     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  55                                                               
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