National Toxicology Program

National Toxicology Program
https://ntp.niehs.nih.gov/go/5237

TR 396 Mouse Pathology Tables


                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                       MONOCHLOROACETIC ACID


NTP Experiment-Test: 05705-01                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 09/18/94
Route: GAVAGE                                                                                                     Time: 19:48:25




       Facility:  International Research and Development Corp.

       Chemical CAS #:  79-11-8

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05705-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 09/18/94  
Route: GAVAGE                                                                                                     Time: 19:48:25  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        CONTROL      50 MG/KG     100MG/KG                                               
                                                   FEMALE        FEMALE       FEMALE                                                
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          60           60           60                                                  
  Early Deaths                                                                                                                      
    Dead                                               9           12            9                                                  
    Moribund                                           8            8            4                                                  
    Dosing Accident                                    1                         3                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                41           40           44                                                  
    Dead                                               1                                                                            
  Animals Examined Microscopically                    60           60           60                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Gallbladder                                        (55)         (1)          (51)                                                
      Calculus Micro Observation Only                  1 (2%)                                                                       
      Hyperplasia, Lymphoid                                                      1 (2%)                                             
      Epithelium, Hyperplasia                          1 (2%)                                                                       
   Intestine Large, Colon                             (59)                      (60)                                                
      Parasite Metazoan                                6 (10%)                   3 (5%)                                             
   Intestine Large, Rectum                            (60)                      (58)                                                
      Hemorrhage                                       2 (3%)                                                                       
      Inflammation, Acute, Focal                       1 (2%)                                                                       
      Ulcer, Acute                                                               1 (2%)                                             
   Intestine Small, Ileum                             (52)                      (54)                                                
      Amyloid Deposition                               1 (2%)                    1 (2%)                                             
      Congestion                                       1 (2%)                                                                       
      Inflammation, Acute                                                        1 (2%)                                             
   Intestine Small, Jejunum                           (52)         (1)          (54)                                                
      Ulcer, Acute                                                               1 (2%)                                             
      Peyer's Patch, Hyperplasia, Lymphoid             1 (2%)       1 (100%)                                                        
   Liver                                              (60)         (60)         (60)                                                
      Basophilic Focus                                                           1 (2%)                                             
      Hematopoietic Cell Proliferation Granulocytic                 1 (2%)       5 (8%)                                             
      Inflammation, Acute                              1 (2%)       1 (2%)       1 (2%)                                             
      Inflammation, Chronic                            6 (10%)     17 (28%)     14 (23%)                                            
      Inflammation, Chronic Active                                  1 (2%)       1 (2%)                                             
      Necrosis, Coagulative                            3 (5%)       1 (2%)                                                          
      Pigmentation                                                  1 (2%)                                                          
      Bile Duct, Hyperplasia                                                     1 (2%)                                             
      Hepatocyte, Necrosis                                          1 (2%)                                                          
   Mesentery                                          (23)         (7)          (16)                                                
      Inflammation, Acute                                                        1 (6%)                                             
      Inflammation, Chronic                           11 (48%)      2 (29%)      8 (50%)                                            
      Artery, Adventitia, Inflammation, Chronic                                                                                     
          Active                                                    1 (14%)                                                         
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05705-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 09/18/94  
Route: GAVAGE                                                                                                     Time: 19:48:25  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        CONTROL      50 MG/KG     100MG/KG                                               
                                                   FEMALE        FEMALE       FEMALE                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
   Pancreas                                           (60)                      (60)                                                
      Atrophy                                          2 (3%)                    4 (7%)                                             
      Clear Cell Focus                                                           1 (2%)                                             
      Inflammation, Chronic                            1 (2%)                    5 (8%)                                             
      Duct, Cyst                                       2 (3%)                    2 (3%)                                             
   Salivary Glands                                    (59)                      (60)                                                
      Inflammation, Chronic                                                      3 (5%)                                             
      Mucocele                                                                   1 (2%)                                             
   Stomach, Forestomach                               (60)         (59)         (60)                                                
      Cyst                                                          1 (2%)                                                          
      Diverticulum                                     1 (2%)                                                                       
      Hyperkeratosis                                                             4 (7%)                                             
      Hyperplasia, Diffuse, Squamous                                             1 (2%)                                             
      Hyperplasia, Focal, Squamous                     5 (8%)       8 (14%)     12 (20%)                                            
      Hyperplasia, Multifocal, Squamous                                          3 (5%)                                             
      Inflammation, Acute                                                        1 (2%)                                             
      Inflammation, Acute, Multifocal                                            1 (2%)                                             
      Inflammation, Chronic                                         3 (5%)       3 (5%)                                             
      Ulcer                                            2 (3%)                    2 (3%)                                             
      Ulcer, Multifocal                                             1 (2%)       1 (2%)                                             
      Vein, Dilatation                                              1 (2%)                                                          
   Stomach, Glandular                                 (57)         (60)         (60)                                                
      Erosion                                          3 (5%)       2 (3%)       2 (3%)                                             
      Hyperplasia, Atypical, Focal                                               1 (2%)                                             
      Hyperplasia, Cystic                              1 (2%)                                                                       
      Inflammation, Chronic                            1 (2%)       1 (2%)                                                          
      Mineralization                                                1 (2%)                                                          
   Tooth                                              (2)                       (2)                                                 
      Developmental Malformation                                                 1 (50%)                                            
      Peridontal Tissue, Cyst                                                    1 (50%)                                            
      Peridontal Tissue, Inflammation, Acute                                     1 (50%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (57)         (1)          (60)                                                
      Inflammation, Acute                              1 (2%)                                                                       
      Inflammation, Chronic Active                                  1 (100%)                                                        
   Heart                                              (60)         (60)         (60)                                                
      Degeneration                                     3 (5%)       2 (3%)       5 (8%)                                             
      Inflammation, Chronic                                         1 (2%)                                                          
      Mineralization                                   1 (2%)                    3 (5%)                                             
      Coronary Artery, Inflammation, Chronic                                     1 (2%)                                             
      Valve, Pigmentation                              8 (13%)     20 (33%)                                                         
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05705-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 09/18/94  
Route: GAVAGE                                                                                                     Time: 19:48:25  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        CONTROL      50 MG/KG     100MG/KG                                               
                                                   FEMALE        FEMALE       FEMALE                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (59)         (1)          (60)                                                
      Angiectasis                                                                1 (2%)                                             
      Basophilic Focus                                 1 (2%)                                                                       
      Fibrosis, Focal                                                            1 (2%)                                             
      Hematopoietic Cell Proliferation Granulocytic    1 (2%)                    4 (7%)                                             
      Hemorrhage                                                                 1 (2%)                                             
      Hyperplasia                                                                1 (2%)                                             
      Hypertrophy                                                                4 (7%)                                             
      Inflammation, Chronic                            1 (2%)                                                                       
      Necrosis                                         1 (2%)                    2 (3%)                                             
      Subcapsular, Hyperplasia                        59 (100%)                 58 (97%)                                            
   Adrenal Gland, Medulla                             (57)                      (59)                                                
      Hyperplasia, Focal                               1 (2%)                                                                       
   Parathyroid Gland                                  (34)                      (43)                                                
      Cyst                                                                       1 (2%)                                             
   Pituitary Gland                                    (55)         (6)          (57)                                                
      Cyst                                             5 (9%)                    3 (5%)                                             
      Hyperplasia, Focal                              16 (29%)                   9 (16%)                                            
      Hypertrophy, Focal                                                         1 (2%)                                             
   Thyroid Gland                                      (60)         (1)          (60)                                                
      Cyst                                             1 (2%)                                                                       
      Inflammation, Acute, Focal                       1 (2%)                                                                       
      Inflammation, Chronic                            2 (3%)                    2 (3%)                                             
      Pigmentation, Cholesterol                        1 (2%)                                                                       
      Follicle, Cyst                                   9 (15%)                   2 (3%)                                             
      Follicular Cell, Hyperplasia                     1 (2%)                    5 (8%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                                               (2)                                                 
      Cyst                                                                       1 (50%)                                            
   Ovary                                              (59)         (24)         (60)                                                
      Abscess                                                                    3 (5%)                                             
      Cyst                                            24 (41%)     12 (50%)     25 (42%)                                            
      Cyst, Multiple                                  11 (19%)      6 (25%)     10 (17%)                                            
      Inflammation, Acute                                           1 (4%)       1 (2%)                                             
      Inflammation, Chronic                            2 (3%)                                                                       
      Mineralization                                   1 (2%)       1 (4%)       2 (3%)                                             
      Artery, Amyloid Deposition                       1 (2%)                                                                       
   Uterus                                             (60)         (43)         (60)                                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05705-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 09/18/94  
Route: GAVAGE                                                                                                     Time: 19:48:25  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        CONTROL      50 MG/KG     100MG/KG                                               
                                                   FEMALE        FEMALE       FEMALE                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Abscess                                                                    2 (3%)                                             
      Inflammation, Acute                                           3 (7%)       2 (3%)                                             
      Thrombosis                                                                 1 (2%)                                             
      Endometrium, Hyperplasia, Cystic                56 (93%)     41 (95%)     45 (75%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (60)         (21)         (60)                                                
      Myelofibrosis                                   26 (43%)     21 (100%)    22 (37%)                                            
      Myeloid Cell, Hyperplasia                        3 (5%)                    4 (7%)                                             
   Lymph Node                                         (60)         (19)         (58)                                                
      Iliac, Fibrosis                                                            1 (2%)                                             
      Iliac, Hematopoietic Cell Proliferation                                                                                       
          Granulocytic                                                           1 (2%)                                             
      Iliac, Hyperplasia, Plasma Cell                  1 (2%)       1 (5%)                                                          
      Iliac, Inflammation, Acute                       1 (2%)                    1 (2%)                                             
      Iliac, Inflammation, Chronic Active                                        1 (2%)                                             
      Iliac, Pigmentation                                                        1 (2%)                                             
      Inguinal, Inflammation, Acute                                              1 (2%)                                             
      Mandibular, Abscess                              1 (2%)                                                                       
      Mandibular, Hyperplasia, Lymphoid                2 (3%)                    1 (2%)                                             
      Mediastinal, Hemorrhage                          1 (2%)                                                                       
      Mediastinal, Hyperplasia, Lymphoid                                         1 (2%)                                             
      Mediastinal, Hyperplasia, Plasma Cell                         1 (5%)                                                          
      Pancreatic, Inflammation, Acute                                            1 (2%)                                             
      Renal, Inflammation, Acute                                                 2 (3%)                                             
   Lymph Node, Mesenteric                             (60)         (12)         (58)                                                
      Hematopoietic Cell Proliferation Granulocytic                              1 (2%)                                             
      Hemorrhage                                       1 (2%)                                                                       
      Hyperplasia, Lymphoid                            3 (5%)                    1 (2%)                                             
      Inflammation, Acute                              1 (2%)                                                                       
      Inflammation, Granulomatous                                                1 (2%)                                             
   Spleen                                             (60)         (25)         (60)                                                
      Fibrosis                                                      2 (8%)                                                          
      Granuloma, Multiple                              1 (2%)                                                                       
      Hematopoietic Cell Proliferation Granulocytic    3 (5%)       2 (8%)       5 (8%)                                             
      Hematopoietic Cell Proliferation Erythrocytic    2 (3%)       1 (4%)       3 (5%)                                             
      Hyperplasia, Lymphoid                            9 (15%)      4 (16%)     17 (28%)                                            
      Hyperplasia, Plasma Cell                         1 (2%)                    1 (2%)                                             
      Inflammation, Granulomatous                                                1 (2%)                                             
      Pigmentation                                                  1 (4%)                                                          
   Thymus                                             (54)         (3)          (53)                                                
      Abscess, Multifocal                              1 (2%)                                                                       
      Atrophy                                          5 (9%)                    2 (4%)                                             
      Cyst                                             8 (15%)      1 (33%)      9 (17%)                                            
      Hyperplasia, Lymphoid                            1 (2%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05705-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 09/18/94  
Route: GAVAGE                                                                                                     Time: 19:48:25  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        CONTROL      50 MG/KG     100MG/KG                                               
                                                   FEMALE        FEMALE       FEMALE                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Inflammation, Acute                              1 (2%)                                                                       
      Necrosis                                                                   2 (4%)                                             
      Pigmentation, Lipofuscin                                                   1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (59)         (4)          (60)                                                
      Fibrosis, Focal                                                            1 (2%)                                             
      Hemorrhage                                                                 1 (2%)                                             
      Inflammation, Chronic                            4 (7%)                                                                       
      Acinus, Hyperplasia                              1 (2%)                                                                       
      Duct, Cyst                                       4 (7%)       1 (25%)      4 (7%)                                             
      Duct, Hyperplasia, Atypical                      1 (2%)                                                                       
   Skin                                               (60)         (50)         (60)                                                
      Acanthosis                                       5 (8%)       2 (4%)       1 (2%)                                             
      Fibrosis                                                                   1 (2%)                                             
      Granuloma                                        1 (2%)                                                                       
      Hyperkeratosis                                                             1 (2%)                                             
      Infiltration Cellular, Mast Cell                              1 (2%)                                                          
      Inflammation, Acute                                           1 (2%)                                                          
      Inflammation, Acute, Chronic                                               1 (2%)                                             
      Inflammation, Chronic                            3 (5%)       3 (6%)       2 (3%)                                             
      Parasite External                                3 (5%)                    3 (5%)                                             
      Ulcer, Acute                                                               1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (60)         (1)          (60)                                                
      Periosteum, Inflammation, Granulomatous          1 (2%)                                                                       
   Skeletal Muscle                                    (3)          (2)          (2)                                                 
      Edema                                                                      1 (50%)                                            
      Fibrosis                                                                   1 (50%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (60)         (1)          (60)                                                
      Compression                                      1 (2%)                                                                       
      Hemorrhage                                       1 (2%)                    1 (2%)                                             
      Mineralization                                  29 (48%)      1 (100%)    24 (40%)                                            
      Necrosis, Focal                                  1 (2%)                                                                       
      Pigmentation, Cholesterol                        1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05705-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 09/18/94  
Route: GAVAGE                                                                                                     Time: 19:48:25  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        CONTROL      50 MG/KG     100MG/KG                                               
                                                   FEMALE        FEMALE       FEMALE                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (14)         (60)                                                
      Congestion                                       1 (2%)       1 (7%)       2 (3%)                                             
      Hemorrhage                                       3 (5%)                    2 (3%)                                             
      Inflammation, Acute, Focal                                                 2 (3%)                                             
      Inflammation, Chronic                                         1 (7%)       1 (2%)                                             
      Alveolar Epithelium, Hyperplasia, Focal          2 (3%)       2 (14%)                                                         
      Alveolus, Crystals                                                         1 (2%)                                             
      Alveolus, Infiltration Cellular, Histiocyte                   1 (7%)       2 (3%)                                             
      Artery, Mineralization                           1 (2%)                                                                       
      Artery, Media, Hypertrophy                       6 (10%)                   9 (15%)                                            
      Bronchus, Fibrosis                                                         1 (2%)                                             
      Interstitium, Fibrosis, Multifocal                                         1 (2%)                                             
      Interstitium, Inflammation, Chronic, Focal                                 1 (2%)                                             
      Perivascular, Infiltration Cellular,                                                                                          
          Lymphocyte                                   8 (13%)      2 (14%)     22 (37%)                                            
      Pleura, Inflammation, Acute, Focal                                         1 (2%)                                             
   Nose                                               (60)         (60)         (60)                                                
      Concretion                                                    1 (2%)                                                          
      Congestion                                       2 (3%)                                                                       
      Cyst                                                                       1 (2%)                                             
      Exudate                                          9 (15%)     15 (25%)     11 (18%)                                            
      Granuloma                                        1 (2%)                    1 (2%)                                             
      Inflammation, Acute                              5 (8%)      15 (25%)     31 (52%)                                            
      Inflammation, Chronic                                         1 (2%)                                                          
      Inflammation, Chronic Active                     2 (3%)       3 (5%)       5 (8%)                                             
      Mucosa, Nasopharyngeal Duct, Hyperplasia         1 (2%)                                                                       
      Mucosa, Nasolacrimal Duct, Hyperplasia          32 (53%)     32 (53%)     39 (65%)                                            
      Nasolacrimal Duct, Hyperplasia                                             1 (2%)                                             
      Nasolacrimal Duct, Inflammation, Acute           1 (2%)                                                                       
      Olfactory Epithelium, Metaplasia                 2 (3%)       5 (8%)      17 (28%)                                            
   Trachea                                            (60)                      (60)                                                
      Inflammation, Acute                                                        3 (5%)                                             
      Metaplasia, Squamous                                                       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                             (1)          (1)                                                 
      Cornea, Inflammation, Chronic                                              1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 05705-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 09/18/94  
Route: GAVAGE                                                                                                     Time: 19:48:25  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE FEMALE                        CONTROL      50 MG/KG     100MG/KG                                               
                                                   FEMALE        FEMALE       FEMALE                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (5)          (60)                                                
      Cyst                                             1 (2%)                                                                       
      Hydronephrosis                                   1 (2%)                                                                       
      Inflammation, Chronic                           17 (28%)                  21 (35%)                                            
      Mineralization                                                             1 (2%)                                             
      Nephropathy                                     11 (18%)                  12 (20%)                                            
      Renal Tubule, Epithelium, Pigmentation                                     1 (2%)                                             
   Urinary Bladder                                    (57)         (1)          (56)                                                
      Inflammation, Chronic                            4 (7%)                    3 (5%)                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 05705-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 09/18/94  
Route: GAVAGE                                                                                                     Time: 19:48:25  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          CONTROL      50 MG/KG     100MG/KG                                               
                                                   MALE          MALE         MALE                                                  
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          60           60           60                                                  
  Early Deaths                                                                                                                      
    Dead                                               7           11           26                                                  
    Moribund                                           5           10            8                                                  
    Dosing Accident                                    2                         5                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                46           39           21                                                  
  Animals Examined Microscopically                    60           60           60                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (59)         (60)         (60)                                                
      Ulcer, Acute                                                  1 (2%)                                                          
   Gallbladder                                        (51)         (52)         (39)                                                
      Cyst                                                          1 (2%)                                                          
      Inflammation, Chronic                                         1 (2%)                                                          
   Intestine Large, Cecum                             (55)         (55)         (44)                                                
      Diverticulum                                                               1 (2%)                                             
      Parasite Metazoan                                                          2 (5%)                                             
   Intestine Large, Colon                             (59)         (58)         (56)                                                
      Infiltration Cellular, Plasma Cell                            1 (2%)                                                          
      Inflammation, Chronic Active                                               1 (2%)                                             
      Parasite Metazoan                                5 (8%)       4 (7%)       9 (16%)                                            
   Intestine Large, Rectum                            (58)         (58)         (50)                                                
      Inflammation, Acute                                           1 (2%)                                                          
      Parasite Metazoan                                                          1 (2%)                                             
   Intestine Small, Ileum                             (54)         (54)         (37)                                                
      Amyloid Deposition                                            1 (2%)                                                          
      Parasite Metazoan                                             1 (2%)                                                          
   Intestine Small, Jejunum                           (53)         (56)         (40)                                                
      Hyperplasia, Lymphoid                            1 (2%)                                                                       
   Liver                                              (60)         (59)         (59)                                                
      Basophilic Focus                                                           1 (2%)                                             
      Basophilic Focus, Multiple                       1 (2%)                                                                       
      Clear Cell Focus                                                           1 (2%)                                             
      Congestion                                                    1 (2%)       1 (2%)                                             
      Cytoplasmic Alteration                                        1 (2%)                                                          
      Hematopoietic Cell Proliferation                                           1 (2%)                                             
      Infarct                                                       2 (3%)                                                          
      Inflammation, Acute                              1 (2%)                    2 (3%)                                             
      Inflammation, Chronic                            3 (5%)       4 (7%)       2 (3%)                                             
      Inflammation, Chronic Active, Multifocal         1 (2%)                                                                       
      Necrosis                                         2 (3%)       4 (7%)       5 (8%)                                             
      Bile Duct, Cyst                                  1 (2%)                    1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    9                                                              
NTP Experiment-Test: 05705-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 09/18/94  
Route: GAVAGE                                                                                                     Time: 19:48:25  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          CONTROL      50 MG/KG     100MG/KG                                               
                                                   MALE          MALE         MALE                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Centrilobular, Fatty Change                                                1 (2%)                                             
      Hepatocyte, Cytomegaly, Diffuse                                            1 (2%)                                             
      Hepatocyte, Necrosis                             1 (2%)                                                                       
   Mesentery                                          (4)          (1)                                                              
      Inflammation, Chronic                            2 (50%)                                                                      
      Artery, Perivascular, Inflammation, Chronic                   1 (100%)                                                        
   Pancreas                                           (58)         (59)         (57)                                                
      Atrophy                                          3 (5%)       1 (2%)       4 (7%)                                             
      Cyst                                                          1 (2%)                                                          
      Hyperplasia, Focal                               1 (2%)                    1 (2%)                                             
      Inflammation, Chronic                            1 (2%)                                                                       
      Necrosis, Multifocal                             1 (2%)                                                                       
      Duct, Cyst                                       1 (2%)                                                                       
   Salivary Glands                                    (60)         (57)         (60)                                                
      Atrophy                                                       2 (4%)                                                          
   Stomach, Forestomach                               (60)         (60)         (59)                                                
      Cyst                                                          1 (2%)       1 (2%)                                             
      Diverticulum                                     3 (5%)                                                                       
      Erosion                                          1 (2%)                                                                       
      Hyperkeratosis                                   1 (2%)                                                                       
      Hyperplasia, Focal, Squamous                     5 (8%)       2 (3%)       8 (14%)                                            
      Hyperplasia, Multifocal, Squamous                                          5 (8%)                                             
      Inflammation, Acute                              1 (2%)                                                                       
      Inflammation, Acute, Multifocal                                            1 (2%)                                             
      Inflammation, Chronic Active                                               1 (2%)                                             
      Ulcer                                                         2 (3%)       1 (2%)                                             
   Stomach, Glandular                                 (58)         (59)         (54)                                                
      Cyst                                                          3 (5%)       1 (2%)                                             
      Erosion                                          1 (2%)       3 (5%)       8 (15%)                                            
      Inflammation, Acute                              1 (2%)       1 (2%)       1 (2%)                                             
      Inflammation, Chronic                                         1 (2%)                                                          
      Epithelium, Hyperplasia, Focal                   1 (2%)                                                                       
   Tooth                                              (5)          (2)          (2)                                                 
      Developmental Malformation                                    1 (50%)                                                         
      Peridontal Tissue, Inflammation, Acute           1 (20%)      1 (50%)                                                         
      Peridontal Tissue, Inflammation, Chronic                                   1 (50%)                                            
      Pulp, Inflammation, Acute                        3 (60%)                   1 (50%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (60)         (59)         (60)                                                
      Abscess, Chronic Active                                                    1 (2%)                                             
      Degeneration                                    21 (35%)     16 (27%)     19 (32%)                                            
      Inflammation, Acute, Multifocal                  1 (2%)                                                                       
      Inflammation, Chronic                                         3 (5%)                                                          
      Mineralization                                   1 (2%)                    3 (5%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   10                                                              
NTP Experiment-Test: 05705-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 09/18/94  
Route: GAVAGE                                                                                                     Time: 19:48:25  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          CONTROL      50 MG/KG     100MG/KG                                               
                                                   MALE          MALE         MALE                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
CARDIOVASCULAR SYSTEM - CONT                                                                                                        
      Atrium, Pigmentation                                          1 (2%)                                                          
      Atrium, Thrombosis                                            1 (2%)       1 (2%)                                             
      Epicardium, Fibrosis                                          1 (2%)                                                          
      Epicardium, Inflammation, Chronic                1 (2%)                                                                       
      Valve, Pigmentation                              8 (13%)     10 (17%)                                                         
      Ventricle, Thrombosis                            1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (60)         (59)         (60)                                                
      Basophilic Focus                                                           1 (2%)                                             
      Cyst                                             1 (2%)                                                                       
      Cytoplasmic Alteration, Focal                    1 (2%)                    1 (2%)                                             
      Hyperplasia                                      4 (7%)       1 (2%)       3 (5%)                                             
      Hyperplasia, Focal                               1 (2%)                                                                       
      Hypertrophy, Focal                               1 (2%)                    1 (2%)                                             
      Subcapsular, Hyperplasia                        54 (90%)     48 (81%)     49 (82%)                                            
   Adrenal Gland, Medulla                             (59)         (59)         (60)                                                
      Fibrosis                                                                   2 (3%)                                             
      Hyperplasia                                      1 (2%)                                                                       
      Hyperplasia, Focal                                                         1 (2%)                                             
   Islets, Pancreatic                                 (56)         (59)         (58)                                                
      Hyperplasia                                      1 (2%)                                                                       
   Parathyroid Gland                                  (41)         (19)         (35)                                                
      Cyst                                             1 (2%)       2 (11%)      1 (3%)                                             
   Pituitary Gland                                    (56)         (57)         (56)                                                
      Congestion                                                                 1 (2%)                                             
      Cyst                                             2 (4%)                    2 (4%)                                             
      Hyperplasia, Focal                               1 (2%)                                                                       
   Thyroid Gland                                      (60)         (58)         (57)                                                
      Inflammation, Chronic                            2 (3%)                                                                       
      Mineralization                                   1 (2%)                                                                       
      Follicle, Cyst                                   6 (10%)      3 (5%)       2 (4%)                                             
      Follicular Cell, Hyperplasia                     1 (2%)       2 (3%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   11                                                              
NTP Experiment-Test: 05705-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 09/18/94  
Route: GAVAGE                                                                                                     Time: 19:48:25  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          CONTROL      50 MG/KG     100MG/KG                                               
                                                   MALE          MALE         MALE                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Coagulating Gland                                               (1)                                                              
      Cyst                                                          1 (100%)                                                        
   Epididymis                                         (60)         (60)         (60)                                                
      Dilatation                                                    1 (2%)                                                          
      Inflammation, Chronic                            1 (2%)                                                                       
   Preputial Gland                                    (8)          (6)          (8)                                                 
      Abscess                                          2 (25%)                                                                      
      Fibrosis                                                                   1 (13%)                                            
      Hemorrhage                                                    1 (17%)                                                         
      Inflammation, Acute                              1 (13%)                                                                      
      Inflammation, Chronic                            1 (13%)      2 (33%)      1 (13%)                                            
      Inflammation, Granulomatous                      3 (38%)                                                                      
      Duct, Cyst                                       5 (63%)      4 (67%)      4 (50%)                                            
   Prostate                                           (59)         (59)         (57)                                                
      Fibrosis                                                      1 (2%)                                                          
      Fibrosis, Focal                                                            1 (2%)                                             
      Inflammation, Acute                              1 (2%)                    2 (4%)                                             
      Inflammation, Chronic                            1 (2%)                                                                       
   Seminal Vesicle                                    (5)          (2)          (5)                                                 
      Dilatation                                       1 (20%)      1 (50%)      1 (20%)                                            
   Testes                                             (60)         (60)         (60)                                                
      Degeneration                                     3 (5%)       4 (7%)       4 (7%)                                             
      Infiltration Cellular, Focal, Lymphocyte                                   1 (2%)                                             
      Mineralization                                   2 (3%)       8 (13%)      2 (3%)                                             
      Unilateral, Atrophy                              2 (3%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (60)         (60)         (60)                                                
      Myeloid Cell, Hyperplasia                        3 (5%)       4 (7%)                                                          
   Lymph Node                                         (58)         (55)         (51)                                                
      Iliac, Hyperplasia, Plasma Cell                                            1 (2%)                                             
      Inguinal, Hyperplasia, Lymphoid                  2 (3%)                                                                       
      Inguinal, Hyperplasia, Plasma Cell               4 (7%)       2 (4%)       1 (2%)                                             
      Inguinal, Inflammation, Acute                    1 (2%)                                                                       
      Inguinal, Pigmentation                           2 (3%)       9 (16%)                                                         
      Mediastinal, Hemorrhage                          1 (2%)                                                                       
      Pancreatic, Hyperplasia, Lymphoid                1 (2%)                                                                       
   Lymph Node, Mesenteric                             (56)         (55)         (50)                                                
      Congestion, Focal                                                          1 (2%)                                             
      Hematopoietic Cell Proliferation Granulocytic    1 (2%)                                                                       
      Hematopoietic Cell Proliferation Erythrocytic                              1 (2%)                                             
      Hyperplasia, Lymphoid                            1 (2%)                    2 (4%)                                             
      Hyperplasia, Plasma Cell                                                   1 (2%)                                             
      Infiltration Cellular, Histiocyte                                          1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   12                                                              
NTP Experiment-Test: 05705-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 09/18/94  
Route: GAVAGE                                                                                                     Time: 19:48:25  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          CONTROL      50 MG/KG     100MG/KG                                               
                                                   MALE          MALE         MALE                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Inflammation, Acute                              1 (2%)       2 (4%)                                                          
      Pigmentation, Hemosiderin                                                  1 (2%)                                             
   Spleen                                             (59)         (58)         (60)                                                
      Atrophy, Focal                                                1 (2%)                                                          
      Cyst                                                                       1 (2%)                                             
      Hematopoietic Cell Proliferation Granulocytic    4 (7%)       3 (5%)                                                          
      Hematopoietic Cell Proliferation Erythrocytic    1 (2%)       1 (2%)       6 (10%)                                            
      Hyperplasia, Lymphoid                            1 (2%)       2 (3%)       5 (8%)                                             
      Hyperplasia, Plasma Cell                         1 (2%)                    3 (5%)                                             
      Infarct                                          1 (2%)                                                                       
      Infiltration Cellular, Histiocyte                                          1 (2%)                                             
      Pigmentation, Hemosiderin                                                  2 (3%)                                             
      Capsule, Fibrosis                                             1 (2%)       1 (2%)                                             
   Thymus                                             (49)         (42)         (38)                                                
      Atrophy                                          4 (8%)       1 (2%)       1 (3%)                                             
      Cyst                                             4 (8%)       3 (7%)       4 (11%)                                            
      Ectopic Parathyroid Gland                        1 (2%)       3 (7%)                                                          
      Necrosis                                                      1 (2%)       1 (3%)                                             
      Epithelial Cell, Hyperplasia                     9 (18%)      7 (17%)      8 (21%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (13)         (9)          (3)                                                 
      Hemorrhage, Focal                                1 (8%)                                                                       
   Skin                                               (60)         (60)         (59)                                                
      Abscess                                          1 (2%)                                                                       
      Acanthosis                                       1 (2%)                    2 (3%)                                             
      Fibrosis                                         1 (2%)       2 (3%)       2 (3%)                                             
      Hyperkeratosis                                   1 (2%)                                                                       
      Hyperplasia, Basal Cell, Focal                   1 (2%)                                                                       
      Inflammation, Acute                                           1 (2%)       2 (3%)                                             
      Inflammation, Chronic                                         1 (2%)       2 (3%)                                             
      Parasite External                                2 (3%)       3 (5%)       7 (12%)                                            
      Ulcer                                            1 (2%)                    4 (7%)                                             
      Epithelium, Atrophy                                                        1 (2%)                                             
      Hair Follicle, Atrophy                                                     2 (3%)                                             
      Prepuce, Abscess                                              1 (2%)                                                          
      Prepuce, Inflammation, Acute                     1 (2%)                    2 (3%)                                             
      Prepuce, Ulcer                                                             3 (5%)                                             
      Scrotal, Ulcer, Acute                                                      1 (2%)                                             
      Subcutaneous Tissue, Inflammation, Chronic       1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   13                                                              
NTP Experiment-Test: 05705-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 09/18/94  
Route: GAVAGE                                                                                                     Time: 19:48:25  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          CONTROL      50 MG/KG     100MG/KG                                               
                                                   MALE          MALE         MALE                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (60)         (60)         (60)                                                
      Fracture Healed                                  1 (2%)                    1 (2%)                                             
      Osteoporosis, Focal                              1 (2%)                                                                       
   Skeletal Muscle                                    (1)          (1)          (1)                                                 
      Inflammation, Chronic                            1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (60)         (58)         (60)                                                
      Congestion                                                    1 (2%)                                                          
      Inflammation, Acute, Multifocal                  1 (2%)                                                                       
      Melanosis                                                     1 (2%)                                                          
      Mineralization                                  45 (75%)     34 (59%)     28 (47%)                                            
      Necrosis, Focal                                  1 (2%)                                                                       
      Meninges, Perivascular, Inflammation, Chronic    1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (59)         (60)                                                
      Congestion                                       1 (2%)       2 (3%)      11 (18%)                                            
      Hemorrhage                                       1 (2%)                    2 (3%)                                             
      Alveolar Epithelium, Hyperplasia, Focal          1 (2%)       4 (7%)       2 (3%)                                             
      Alveolus, Infiltration Cellular, Histiocyte      2 (3%)       3 (5%)       3 (5%)                                             
      Interstitium, Inflammation, Chronic                           2 (3%)       2 (3%)                                             
      Perivascular, Infiltration Cellular,                                                                                          
          Lymphocyte                                   5 (8%)       6 (10%)      2 (3%)                                             
      Pleura, Fibrosis                                              1 (2%)                                                          
   Nose                                               (60)         (59)         (60)                                                
      Exudate                                         15 (25%)     18 (31%)     22 (37%)                                            
      Granuloma                                        2 (3%)       1 (2%)                                                          
      Inflammation, Acute                              3 (5%)       7 (12%)     24 (40%)                                            
      Inflammation, Chronic                            2 (3%)       2 (3%)                                                          
      Inflammation, Chronic Active                                  2 (3%)                                                          
      Mucosa, Turbinate, Hyperplasia                                             1 (2%)                                             
      Mucosa, Nasolacrimal Duct, Hyperplasia          23 (38%)     28 (47%)     24 (40%)                                            
      Nasolacrimal Duct, Inflammation, Acute           1 (2%)       2 (3%)       3 (5%)                                             
      Nasolacrimal Duct, Inflammation, Chronic                                                                                      
          Active                                       1 (2%)                                                                       
      Olfactory Epithelium, Metaplasia                              3 (5%)       2 (3%)                                             
      Submucosa, Cyst                                  1 (2%)                                                                       
      Turbinate, Atrophy                                                         1 (2%)                                             
      Turbinate, Inflammation, Chronic, Multifocal     1 (2%)                                                                       
      Vomeronasal Organ, Cyst                          1 (2%)                                                                       
   Trachea                                            (60)         (59)         (60)                                                
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   14                                                              
NTP Experiment-Test: 05705-01         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 09/18/94  
Route: GAVAGE                                                                                                     Time: 19:48:25  
____________________________________________________________________________________________________________________________________
         B6C3F1 MICE MALE                          CONTROL      50 MG/KG     100MG/KG                                               
                                                   MALE          MALE         MALE                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
RESPIRATORY SYSTEM - CONT                                                                                                           
      Inflammation, Acute                                                        1 (2%)                                             
      Inflammation, Chronic                                                      1 (2%)                                             
      Inflammation, Chronic Active                                               1 (2%)                                             
      Metaplasia, Squamous                                          1 (2%)                                                          
      Ulcer, Acute                                                  1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                             (3)                                                              
      Inflammation, Acute                                           1 (33%)                                                         
      Neovascularization                                            2 (67%)                                                         
      Cornea, Necrosis                                              1 (33%)                                                         
   Harderian Gland                                    (3)          (3)          (2)                                                 
      Cyst, Multiple                                   1 (33%)                                                                      
      Inflammation, Chronic                            1 (33%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (59)         (60)                                                
      Cyst                                             3 (5%)       4 (7%)       5 (8%)                                             
      Inflammation, Acute                              1 (2%)                    2 (3%)                                             
      Mineralization                                   2 (3%)       2 (3%)       2 (3%)                                             
      Nephropathy                                     36 (60%)     38 (64%)     28 (47%)                                            
      Capsule, Fibrosis                                                          1 (2%)                                             
      Pelvis, Inflammation, Chronic                    2 (3%)                                                                       
      Renal Tubule, Hyperplasia, Focal                 1 (2%)                                                                       
      Renal Tubule, Necrosis, Acute                                              6 (10%)                                            
   Urinary Bladder                                    (57)         (58)         (54)                                                
      Calculus Gross Observation                       1 (2%)                                                                       
      Diverticulum                                     1 (2%)                                                                       
      Ectopic Tissue                                                             1 (2%)                                             
      Inflammation, Acute                              1 (2%)                    2 (4%)                                             
      Inflammation, Chronic                            1 (2%)                                                                       
      Transitional Epithelium, Hyperplasia, Focal                                1 (2%)                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   15                                                              
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------                                           
NTP is located at the National Institute of Environmental Health Sciences, part of the National Institutes of Health.