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TR 396 Mouse Pathology Tables


                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                       MONOCHLOROACETIC ACID


NTP Experiment-Test: 05705-01                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 09/18/94
Route: GAVAGE                                                                                                     Time: 19:48:26




       Facility:  International Research and Development Corp.

       Chemical CAS #:  79-11-8

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05705-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 09/18/94  
Route: GAVAGE                                                                                                     Time: 19:48:26  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      50 MG/KG     100MG/KG                                               
                                                   FEMALE        FEMALE       FEMALE                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          60           60           60                                                  
  Early Deaths                                                                                                                      
    Dead                                               9           12            9                                                  
    Moribund                                           8            8            4                                                  
    Dosing Accident                                    1                         3                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                41           40           44                                                  
    Dead                                               1                                                                            
  Animals Examined Microscopically                    60           60           60                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (60)                      (60)                                                
   Gallbladder                                        (55)         (1)          (51)                                                
      Histiocytic Sarcoma                                                        1 (2%)                                             
   Intestine Large, Cecum                             (52)                      (53)                                                
      Histiocytic Sarcoma                                                        1 (2%)                                             
   Intestine Large, Rectum                            (60)                      (58)                                                
      Histiocytic Sarcoma                              1 (2%)                                                                       
   Intestine Small, Ileum                             (52)                      (54)                                                
      Histiocytic Sarcoma                                                        1 (2%)                                             
   Intestine Small, Jejunum                           (52)         (1)          (54)                                                
      Histiocytic Sarcoma                                                        1 (2%)                                             
   Liver                                              (60)         (60)         (60)                                                
      Granulosa Cell Tumor Malignant, Metastatic,                                                                                   
           Ovary                                                    1 (2%)                                                          
      Hemangiosarcoma                                  1 (2%)                                                                       
      Hepatocellular Carcinoma                                      1 (2%)                                                          
      Hepatocellular Adenoma                           1 (2%)       1 (2%)       2 (3%)                                             
      Histiocytic Sarcoma                              3 (5%)       2 (3%)       1 (2%)                                             
   Mesentery                                          (23)         (7)          (16)                                                
      Histiocytic Sarcoma                              2 (9%)       1 (14%)      1 (6%)                                             
      Sarcoma, Metastatic, Uterus                                                1 (6%)                                             
   Pancreas                                           (60)                      (60)                                                
      Histiocytic Sarcoma                                                        1 (2%)                                             
      Sarcoma, Metastatic, Uterus                                                1 (2%)                                             
   Salivary Glands                                    (59)                      (60)                                                
      Histiocytic Sarcoma                                                        1 (2%)                                             
   Stomach, Forestomach                               (60)         (59)         (60)                                                
      Squamous Cell Papilloma                                                    2 (3%)                                             
   Stomach, Glandular                                 (57)         (60)         (60)                                                
      Histiocytic Sarcoma                                           1 (2%)       1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                             Page   2                                                               
NTP Experiment-Test: 05705-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 09/18/94  
Route: GAVAGE                                                                                                     Time: 19:48:26  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      50 MG/KG     100MG/KG                                               
                                                   FEMALE        FEMALE       FEMALE                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (60)         (60)         (60)                                                
      Fibrosarcoma, Metastatic, Skin                                1 (2%)                                                          
      Histiocytic Sarcoma                              2 (3%)       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (59)         (1)          (60)                                                
      Histiocytic Sarcoma                                                        1 (2%)                                             
      Subcapsular, Adenoma                             1 (2%)                                                                       
   Adrenal Gland, Medulla                             (57)                      (59)                                                
      Pheochromocytoma Malignant                       1 (2%)                                                                       
      Pheochromocytoma Benign                                                    1 (2%)                                             
   Islets, Pancreatic                                 (59)                      (59)                                                
      Adenoma                                          1 (2%)                                                                       
   Parathyroid Gland                                  (34)                      (43)                                                
   Pituitary Gland                                    (55)         (6)          (57)                                                
      Adenoma                                          5 (9%)       6 (100%)     7 (12%)                                            
      Pars Intermedia, Adenoma                         1 (2%)                    1 (2%)                                             
   Thyroid Gland                                      (60)         (1)          (60)                                                
      Histiocytic Sarcoma                                                        1 (2%)                                             
      Follicular Cell, Adenoma                         1 (2%)       1 (100%)     2 (3%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Ovary                                              (59)         (24)         (60)                                                
      Adenocarcinoma, Metastatic, Uterus                                         1 (2%)                                             
      Adenoma, Papillary                               1 (2%)                                                                       
      Choriocarcinoma                                               1 (4%)                                                          
      Cystadenoma                                      1 (2%)                                                                       
      Granulosa Cell Tumor Malignant                                1 (4%)                                                          
      Granulosa Cell Tumor Benign                      1 (2%)       1 (4%)                                                          
      Histiocytic Sarcoma                              2 (3%)       1 (4%)                                                          
      Mixed Tumor Benign                               1 (2%)                                                                       
   Oviduct                                            (1)                                                                           
   Uterus                                             (60)         (43)         (60)                                                
      Adenocarcinoma                                                             2 (3%)                                             
      Hemangioma                                                                 1 (2%)                                             
      Histiocytic Sarcoma                              1 (2%)       1 (2%)                                                          
                                                             Page   3                                                               
NTP Experiment-Test: 05705-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 09/18/94  
Route: GAVAGE                                                                                                     Time: 19:48:26  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      50 MG/KG     100MG/KG                                               
                                                   FEMALE        FEMALE       FEMALE                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - cont                                                                                                               
      Leiomyosarcoma                                                             1 (2%)                                             
      Sarcoma                                                                    1 (2%)                                             
      Endometrium, Deciduoma Benign                    1 (2%)                                                                       
      Endometrium, Histiocytic Sarcoma                                           1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (60)         (21)         (60)                                                
      Plasma Cell Tumor NOS                                                      1 (2%)                                             
   Lymph Node                                         (60)         (19)         (58)                                                
      Axillary, Sarcoma, Metastatic                                 1 (5%)                                                          
      Bronchial, Histiocytic Sarcoma                   1 (2%)                                                                       
      Iliac, Histiocytic Sarcoma                       1 (2%)       1 (5%)       1 (2%)                                             
      Inguinal, Histiocytic Sarcoma                                              1 (2%)                                             
      Mediastinal, Fibrosarcoma, Metastatic, Skin                   1 (5%)                                                          
      Mediastinal, Histiocytic Sarcoma                                           1 (2%)                                             
      Pancreatic, Histiocytic Sarcoma                               1 (5%)                                                          
      Renal, Histiocytic Sarcoma                                    1 (5%)       1 (2%)                                             
   Lymph Node, Mesenteric                             (60)         (12)         (58)                                                
      Histiocytic Sarcoma                              2 (3%)       1 (8%)       1 (2%)                                             
      Sarcoma, Metastatic, Uterus                                                1 (2%)                                             
   Spleen                                             (60)         (25)         (60)                                                
      Histiocytic Sarcoma                              1 (2%)       1 (4%)       2 (3%)                                             
   Thymus                                             (54)         (3)          (53)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (59)         (4)          (60)                                                
      Adenocarcinoma                                   2 (3%)       2 (50%)      1 (2%)                                             
      Adenocarcinoma, Multiple                                                   1 (2%)                                             
      Fibrosarcoma, Metastatic, Skin                   1 (2%)                                                                       
      Histiocytic Sarcoma                              1 (2%)                    1 (2%)                                             
   Skin                                               (60)         (50)         (60)                                                
      Fibrosarcoma                                     2 (3%)       2 (4%)       1 (2%)                                             
      Sarcoma                                                       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (60)         (1)          (60)                                                
   Skeletal Muscle                                    (3)          (2)          (2)                                                 
      Adenocarcinoma, Metastatic, Uterus                                         1 (50%)                                            
      Fibrosarcoma, Metastatic, Skin                   1 (33%)                                                                      
      Sarcoma                                          1 (33%)                                                                      
____________________________________________________________________________________________________________________________________
                                                             Page   4                                                               
NTP Experiment-Test: 05705-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 09/18/94  
Route: GAVAGE                                                                                                     Time: 19:48:26  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      50 MG/KG     100MG/KG                                               
                                                   FEMALE        FEMALE       FEMALE                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (60)         (1)          (60)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (14)         (60)                                                
      Alveolar/Bronchiolar Adenoma                                  2 (14%)      2 (3%)                                             
      Alveolar/Bronchiolar Carcinoma                                1 (7%)                                                          
      Fibrosarcoma, Metastatic, Skin                   1 (2%)       1 (7%)                                                          
      Histiocytic Sarcoma                                           1 (7%)       1 (2%)                                             
   Nose                                               (60)         (60)         (60)                                                
   Trachea                                            (60)                      (60)                                                
      Histiocytic Sarcoma                                                        1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                             (1)          (1)                                                 
   Harderian Gland                                    (1)                                                                           
      Adenoma                                          1 (100%)                                                                     
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (5)          (60)                                                
      Adenocarcinoma, Metastatic, Uterus                                         1 (2%)                                             
      Histiocytic Sarcoma                                           1 (20%)      2 (3%)                                             
   Ureter                                             (1)          (1)                                                              
   Urinary Bladder                                    (57)         (1)          (56)                                                
      Histiocytic Sarcoma                              1 (2%)                    1 (2%)                                             
      Sarcoma, Metastatic, Uterus                                                1 (2%)                                             
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(60)        *(60)        *(60)                                                
      Histiocytic Sarcoma                              3 (5%)       2 (3%)       3 (5%)                                             
      Lymphoma Malignant Lymphocytic                   2 (3%)       3 (5%)                                                          
      Lymphoma Malignant Mixed                        27 (45%)     14 (23%)     13 (22%)                                            
      Lymphoma Malignant Undifferentiated Cell                      1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   5                                                               
NTP Experiment-Test: 05705-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 09/18/94  
Route: GAVAGE                                                                                                     Time: 19:48:26  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE FEMALE                        CONTROL      50 MG/KG     100MG/KG                                               
                                                   FEMALE        FEMALE       FEMALE                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            41          33          27                                                   
     Total Primary Neoplasms                           55          40          42                                                   
                                                                                                                                    
   Total Animals with Benign Neoplasms                 14          11          13                                                   
     Total Benign Neoplasms                            16          11          18                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms              36          27          20                                                   
     Total Malignant Neoplasms                         39          29          23                                                   
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              1           3           2                                                   
     Total Metastatic Neoplasm                          3           5           7                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                          1                                                   
     Total Uncertain Neoplasms                                                  1                                                   
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   6                                                               
NTP Experiment-Test: 05705-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 09/18/94  
Route: GAVAGE                                                                                                     Time: 19:48:26  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      50 MG/KG     100MG/KG                                               
                                                   MALE          MALE         MALE                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          60           60           60                                                  
  Early Deaths                                                                                                                      
    Dead                                               7           11           26                                                  
    Moribund                                           5           10            8                                                  
    Dosing Accident                                    2                         5                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                46           39           21                                                  
  Animals Examined Microscopically                    60           60           60                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (59)         (60)         (60)                                                
   Intestine Large, Rectum                            (58)         (58)         (50)                                                
      Adenocarcinoma                                                1 (2%)                                                          
   Intestine Small, Jejunum                           (53)         (56)         (40)                                                
   Liver                                              (60)         (59)         (59)                                                
      Carcinoma, Metastatic, Uncertain Primary Site    1 (2%)                                                                       
      Hemangioma                                       2 (3%)                                                                       
      Hemangiosarcoma                                               1 (2%)       1 (2%)                                             
      Hepatocellular Carcinoma                         6 (10%)      2 (3%)       5 (8%)                                             
      Hepatocellular Adenoma                           6 (10%)      6 (10%)      1 (2%)                                             
   Mesentery                                          (4)          (1)                                                              
      Sarcoma, Metastatic, Skin                        1 (25%)                                                                      
   Pancreas                                           (58)         (59)         (57)                                                
   Pharynx                                            (1)                                                                           
      Palate, Mast Cell Tumor Malignant                1 (100%)                                                                     
   Stomach, Glandular                                 (58)         (59)         (54)                                                
      Carcinoma, Metastatic, Uncertain Primary Site    1 (2%)                                                                       
   Tooth                                              (5)          (2)          (2)                                                 
      Peridontal Tissue, Mast Cell Tumor Malignant     1 (20%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (58)         (58)         (59)                                                
      Fibrosarcoma, Metastatic, Skin                                1 (2%)                                                          
   Heart                                              (60)         (59)         (60)                                                
      Fibrosarcoma, Metastatic, Skin                                1 (2%)                                                          
      Hemangioma                                                    1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   7                                                               
NTP Experiment-Test: 05705-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 09/18/94  
Route: GAVAGE                                                                                                     Time: 19:48:26  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      50 MG/KG     100MG/KG                                               
                                                   MALE          MALE         MALE                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (60)         (59)         (60)                                                
      Adenoma                                                       1 (2%)                                                          
      Carcinoma                                                     1 (2%)                                                          
      Subcapsular, Adenoma                             2 (3%)       1 (2%)       2 (3%)                                             
   Adrenal Gland, Medulla                             (59)         (59)         (60)                                                
      Pheochromocytoma Benign                                       1 (2%)       1 (2%)                                             
   Thyroid Gland                                      (60)         (58)         (57)                                                
      Follicular Cell, Adenoma                         1 (2%)                                                                       
      Follicular Cell, Carcinoma                       1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Preputial Gland                                    (8)          (6)          (8)                                                 
      Sarcoma, Metastatic, Skin                        1 (13%)                                                                      
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (60)         (60)         (60)                                                
   Lymph Node                                         (58)         (55)         (51)                                                
      Mediastinal, Fibrosarcoma, Metastatic, Skin                   1 (2%)                                                          
      Pancreatic, Carcinoma, Metastatic, Uncertain                                                                                  
          Primary Site                                 1 (2%)                                                                       
   Lymph Node, Mesenteric                             (56)         (55)         (50)                                                
      Hemangiosarcoma                                  1 (2%)                                                                       
      Sarcoma, Metastatic, Skin                        1 (2%)                                                                       
   Spleen                                             (59)         (58)         (60)                                                
      Hemangioma                                       1 (2%)                                                                       
   Thymus                                             (49)         (42)         (38)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Skin                                               (60)         (60)         (59)                                                
      Fibrosarcoma                                                  4 (7%)       3 (5%)                                             
      Fibrosarcoma, Multiple                           1 (2%)                                                                       
      Neurofibrosarcoma                                                          2 (3%)                                             
      Sarcoma                                          1 (2%)                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   8                                                               
NTP Experiment-Test: 05705-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 09/18/94  
Route: GAVAGE                                                                                                     Time: 19:48:26  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      50 MG/KG     100MG/KG                                               
                                                   MALE          MALE         MALE                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Skeletal Muscle                                    (1)          (1)          (1)                                                 
      Fibrosarcoma, Metastatic                                                   1 (100%)                                           
      Thoracic, Fibrosarcoma, Metastatic, Skin                      1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (60)         (58)         (60)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (60)         (59)         (60)                                                
      Alveolar/Bronchiolar Adenoma                     6 (10%)     10 (17%)      4 (7%)                                             
      Alveolar/Bronchiolar Adenoma, Multiple           3 (5%)                    1 (2%)                                             
      Alveolar/Bronchiolar Carcinoma                   4 (7%)                                                                       
      Fibrosarcoma, Metastatic, Skin                                2 (3%)       1 (2%)                                             
      Hepatocellular Carcinoma, Metastatic, Liver      2 (3%)       1 (2%)                                                          
      Sarcoma, Metastatic, Uncertain Primary Site      1 (2%)                                                                       
   Nose                                               (60)         (59)         (60)                                                
   Trachea                                            (60)         (59)         (60)                                                
      Fibrosarcoma, Metastatic, Skin                                2 (3%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Harderian Gland                                    (3)          (3)          (2)                                                 
      Adenoma                                          2 (67%)      3 (100%)     2 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (60)         (59)         (60)                                                
      Sarcoma, Metastatic, Skin                        1 (2%)                                                                       
   Urinary Bladder                                    (57)         (58)         (54)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(60)        *(60)        *(60)                                                
      Lymphoma Malignant Mixed                         8 (13%)      7 (12%)      5 (8%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   9                                                               
NTP Experiment-Test: 05705-01  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 09/18/94  
Route: GAVAGE                                                                                                     Time: 19:48:26  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         B6C3F1 MICE MALE                          CONTROL      50 MG/KG     100MG/KG                                               
                                                   MALE          MALE         MALE                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            31          32          21                                                   
     Total Primary Neoplasms                           47          39          28                                                   
                                                                                                                                    
   Total Animals with Benign Neoplasms                 20          21          11                                                   
     Total Benign Neoplasms                            23          23          11                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms              20          14          13                                                   
     Total Malignant Neoplasms                         24          16          17                                                   
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              5           3           2                                                   
     Total Metastatic Neoplasm                         10           9           2                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms               2                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  10                                                               
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                             ----------              END OF REPORT             ----------                                           
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