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TR 396 Mouse Pathology Tables

NTP Experiment-Test: 05705-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97
Route: GAVAGE                                                                                                     Time: 12:50:12




       Facility:  International Research and Development Corp.

       Chemical CAS #:  79-11-8

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All






































                                                              Page   1

NTP Experiment-Test: 05705-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 12:50:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 4| 7| 7| 7| 7| 1| 7| 6| 7| 7| 5| 6| 7| 6| 7|             
                             DAY ON TEST   | 3| 2| 2| 2| 3| 2| 2| 8| 3| 3| 6| 0| 3| 3| 0| 5| 3| 8| 3| 3| 1| 7| 3| 7| 3|             
                                           | 1| 9| 9| 9| 0| 9| 9| 3| 1| 0| 3| 9| 1| 1| 8| 3| 1| 2| 0| 0| 3| 1| 0| 9| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    CONTROL                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A  +|             
      Calculus Micro Observation Only      |                                                                          |             
      Epithelium, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                           X                              |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                           2                              |             
      Inflammation, Acute, Focal           |                                                                         1|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  A  +  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                                                                          |             
      Congestion                           |                                           3                              |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
      Peyer's Patch, Hyperplasia, Lymphoid |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  | 1                                                                        |             
      Inflammation, Chronic                |    1  2           2                                                      |             
      Necrosis, Coagulative                |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               | +     +              +  +  +  +           +                 +  +  +  +   |             
      Inflammation, Chronic                | 2     2                 2  1  1                                   1      |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                         3|             
      Inflammation, Chronic                |                                     3                                    |             
      Duct, Cyst                           |                                                                         X|             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Diverticulum                         |    2                                                                     |             
      Hyperplasia, Focal, Squamous         |                                                                          |             
      Ulcer                                |                   2                                                      |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                           1        2                     |             
      Hyperplasia, Cystic                  |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                  +                                       |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                                        1                                 |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05705-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 12:50:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 4| 7| 7| 7| 7| 1| 7| 6| 7| 7| 5| 6| 7| 6| 7|             
                             DAY ON TEST   | 3| 2| 2| 2| 3| 2| 2| 8| 3| 3| 6| 0| 3| 3| 0| 5| 3| 8| 3| 3| 1| 7| 3| 7| 3|             
                                           | 1| 9| 9| 9| 0| 9| 9| 3| 1| 0| 3| 9| 1| 1| 8| 3| 1| 2| 0| 0| 3| 1| 0| 9| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    CONTROL                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Degeneration                         |                                                                          |             
      Mineralization                       |                                                                          |             
      Valve, Pigmentation                  |       2                          2                       1        2      |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                                       X                  |             
      Hematopoietic Cell Proliferation     |                                                                          |             
          Granulocytic                     |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Necrosis                             |                                                                          |             
      Subcapsular, Hyperplasia             | 3  3  3  3  3  3  3  3  4  3  3  2  3  3  3  3  2  2  3  2  2  3  3  2  3|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                     1                                    |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  +  M  +  +  +  M  +  +  +  +  +  +  +  M  M  M  +  M  M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  I  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hyperplasia, Focal                   |                   1        4           2                       2     2  2|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Inflammation, Acute, Focal           |                                                                   1      |             
      Inflammation, Chronic                |                                                                          |             
      Pigmentation, Cholesterol            |                                           2                              |             
      Follicle, Cyst                       |                                        X  X                          X   |             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +|             
      Cyst                                 | X  X  X                    X        X  X  X           X     X     X  X  X|             
      Cyst, Multiple                       |             X  X        X                       X  X                     |             
      Inflammation, Chronic                |                                     4                                    |             
      Mineralization                       |                            2                                             |             
      Artery, Amyloid Deposition           |                                                                          |             
                                            __________________________________________________________________________|             
   Oviduct                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Endometrium, Hyperplasia, Cystic     | 2  3  3  3  3  2  3     3  3  1  2  3  3  1     3  1  4  3  1  1  3  1  2|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05705-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 12:50:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 4| 7| 7| 7| 7| 1| 7| 6| 7| 7| 5| 6| 7| 6| 7|             
                             DAY ON TEST   | 3| 2| 2| 2| 3| 2| 2| 8| 3| 3| 6| 0| 3| 3| 0| 5| 3| 8| 3| 3| 1| 7| 3| 7| 3|             
                                           | 1| 9| 9| 9| 0| 9| 9| 3| 1| 0| 3| 9| 1| 1| 8| 3| 1| 2| 0| 0| 3| 1| 0| 9| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    CONTROL                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Myelofibrosis                        | 2           3     3     1        2  1              2  2  1              1|             
      Myeloid Cell, Hyperplasia            |                                        2                                 |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Iliac, Hyperplasia, Plasma Cell      |                                                                          |             
      Iliac, Inflammation, Acute           |                                                                          |             
      Mandibular, Abscess                  |                                                                          |             
      Mandibular, Hyperplasia, Lymphoid    |          3                                                               |             
      Mediastinal, Hemorrhage              |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granuloma, Multiple                  |    3                                                                     |             
      Hematopoietic Cell Proliferation     |                                                                          |             
          Granulocytic                     |                                                             X            |             
      Hematopoietic Cell Proliferation     |                                                                          |             
          Erythrocytic                     |                                  4                                       |             
      Hyperplasia, Lymphoid                | 3     4  2     4  3                                      3               |             
      Hyperplasia, Plasma Cell             |                                     1                                    |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Abscess, Multifocal                  |                                                                          |             
      Atrophy                              |                                     1        3              3            |             
      Cyst                                 |          X              X  X                             X  X            |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                 1                        |             
      Acinus, Hyperplasia                  |    3                                                                     |             
      Duct, Cyst                           |                                                                          |             
      Duct, Hyperplasia, Atypical          |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |             2                          2                                2|             
      Granuloma                            |                   1                                                      |             
      Inflammation, Chronic                |                                              1                           |             
      Parasite External                    |    X                                                                     |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Periosteum, Inflammation,            |                                                                          |             
          Granulomatous                    |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                      +   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05705-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 12:50:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 4| 7| 7| 7| 7| 1| 7| 6| 7| 7| 5| 6| 7| 6| 7|             
                             DAY ON TEST   | 3| 2| 2| 2| 3| 2| 2| 8| 3| 3| 6| 0| 3| 3| 0| 5| 3| 8| 3| 3| 1| 7| 3| 7| 3|             
                                           | 1| 9| 9| 9| 0| 9| 9| 3| 1| 0| 3| 9| 1| 1| 8| 3| 1| 2| 0| 0| 3| 1| 0| 9| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    CONTROL                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |    2                                                                     |             
      Hemorrhage                           |                                                                          |             
      Mineralization                       |       2     2  2  2        1  1        3        2  2     2  1           1|             
      Necrosis, Focal                      |                                     2                                    |             
      Pigmentation, Cholesterol            |                                     2                                    |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hemorrhage                           |                                     1                                    |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                                       2        3         |             
      Artery, Mineralization               |                                                                          |             
      Artery, Media, Hypertrophy           |       1                       2        1                                1|             
      Perivascular, Infiltration Cellular, |                                                                          |             
           Lymphocyte                      |       2                       1                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                      4   |             
      Exudate                              |             1           1              1                          1     1|             
      Granuloma                            |                                                                          |             
      Inflammation, Acute                  |                                                                1         |             
      Inflammation, Chronic Active         |                                                                          |             
      Mucosa, Nasopharyngeal Duct,         |                                                                          |             
          Hyperplasia                      |                                                                          |             
      Mucosa, Nasolacrimal Duct,           |                                                                          |             
          Hyperplasia                      |    1  2  1              1  1        1  1  2        2  1  1  1           2|             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Acute                           |                                                                          |             
      Olfactory Epithelium, Metaplasia     |       1                                                                  |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |             +                                                            |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                           X                              |             
      Hydronephrosis                       |                                                                          |             
      Inflammation, Chronic                | 1  1              2     2     1        2              1  1              1|             
      Nephropathy                          |          2  1        2           2  1     1                              |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05705-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 12:50:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 4| 7| 7| 7| 7| 1| 7| 6| 7| 7| 5| 6| 7| 6| 7|             
                             DAY ON TEST   | 3| 2| 2| 2| 3| 2| 2| 8| 3| 3| 6| 0| 3| 3| 0| 5| 3| 8| 3| 3| 1| 7| 3| 7| 3|             
                                           | 1| 9| 9| 9| 0| 9| 9| 3| 1| 0| 3| 9| 1| 1| 8| 3| 1| 2| 0| 0| 3| 1| 0| 9| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    CONTROL                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ureter                                  |                                           +                              |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |       3                                                                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   6                                                               
NTP Experiment-Test: 05705-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 12:50:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 6| 6| 7|             
                             DAY ON TEST   | 1| 3| 3| 2| 3| 3| 2| 3| 2| 3| 2| 2| 3| 8| 3| 3| 2| 3| 2| 2| 2| 3| 5| 3| 3|             
                                           | 1| 1| 1| 2| 0| 1| 9| 0| 4| 0| 9| 9| 1| 7| 0| 0| 9| 1| 9| 7| 9| 0| 7| 6| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Calculus Micro Observation Only      |                                                                          |             
      Epithelium, Hyperplasia              |                                                                      3   |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  M  +  +  A  A  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    | X     X                                                  X               |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Inflammation, Acute, Focal           |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +|             
      Amyloid Deposition                   |                                                                          |             
      Congestion                           |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  A  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +|             
      Peyer's Patch, Hyperplasia, Lymphoid |                                                       3                  |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |             1     2                 1                                    |             
      Necrosis, Coagulative                | 4        2                                                        3      |             
                                            __________________________________________________________________________|             
   Mesentery                               |       +           +        +        +  +        +                       +|             
      Inflammation, Chronic                |                   2        1                    2                       2|             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Duct, Cyst                           |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Diverticulum                         |                                                                          |             
      Hyperplasia, Focal, Squamous         |                3                    1           2     1                  |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Erosion                              |                                                                          |             
      Hyperplasia, Cystic                  |                                                 2                        |             
      Inflammation, Chronic                |                   1                                                      |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   7                                                               
NTP Experiment-Test: 05705-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 12:50:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 6| 6| 7|             
                             DAY ON TEST   | 1| 3| 3| 2| 3| 3| 2| 3| 2| 3| 2| 2| 3| 8| 3| 3| 2| 3| 2| 2| 2| 3| 5| 3| 3|             
                                           | 1| 1| 1| 2| 0| 1| 9| 0| 4| 0| 9| 9| 1| 7| 0| 0| 9| 1| 9| 7| 9| 0| 7| 6| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
      Degeneration                         |                                                                   2      |             
      Mineralization                       |                                                                          |             
      Valve, Pigmentation                  |       1     1                                         2                  |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
          Granulocytic                     |                                                                          |             
      Inflammation, Chronic                |                      1                                                   |             
      Necrosis                             | 2                                                                        |             
      Subcapsular, Hyperplasia             | 3  3  3  3     3  3  4  3  3  3  2  3  3  2  3  3  3  2  3  3  3  3  3  3|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  M  M  +  +  +  M  M  +  M  M  M  M  +  M  M  +  +  M  M  M  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
      Cyst                                 |    X                       X                                X        X   |             
      Hyperplasia, Focal                   |    3     2     3                             3                    3     2|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Inflammation, Acute, Focal           |                                                                          |             
      Inflammation, Chronic                |                         1  1                                             |             
      Pigmentation, Cholesterol            |                                                                          |             
      Follicle, Cyst                       |                X        X              X                 X     X  X      |             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 | X                 X  X                       X  X     X  X     X         |             
      Cyst, Multiple                       |                            X                       X        X           X|             
      Inflammation, Chronic                |                                                                          |             
      Mineralization                       |                                                                          |             
      Artery, Amyloid Deposition           |                                                          2               |             
                                            __________________________________________________________________________|             
   Oviduct                                 |                                                 +                        |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Endometrium, Hyperplasia, Cystic     | 1  3  3  1  3  4  4  2     4  2  2  4  1  3  4  2  3  4  2  4  1  1  1  3|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   8                                                               
NTP Experiment-Test: 05705-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 12:50:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 6| 6| 7|             
                             DAY ON TEST   | 1| 3| 3| 2| 3| 3| 2| 3| 2| 3| 2| 2| 3| 8| 3| 3| 2| 3| 2| 2| 2| 3| 5| 3| 3|             
                                           | 1| 1| 1| 2| 0| 1| 9| 0| 4| 0| 9| 9| 1| 7| 0| 0| 9| 1| 9| 7| 9| 0| 7| 6| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Myelofibrosis                        |    1        1  1  2     1           2  1              3  2  1            |             
      Myeloid Cell, Hyperplasia            |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Iliac, Hyperplasia, Plasma Cell      |                                                                          |             
      Iliac, Inflammation, Acute           |                                                                          |             
      Mandibular, Abscess                  |                                                                          |             
      Mandibular, Hyperplasia, Lymphoid    |                                                                   3      |             
      Mediastinal, Hemorrhage              |          2                                                               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                   3      |             
      Hyperplasia, Lymphoid                |                      2              2                                2   |             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Granuloma, Multiple                  |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
          Granulocytic                     |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
          Erythrocytic                     | 3                                                                        |             
      Hyperplasia, Lymphoid                |                   4                                         2        2   |             
      Hyperplasia, Plasma Cell             |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  I  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +|             
      Abscess, Multifocal                  |                                                                          |             
      Atrophy                              | 2                                                        2               |             
      Cyst                                 |                X           X              X                              |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                      1                                                  1|             
      Acinus, Hyperplasia                  |                                                                          |             
      Duct, Cyst                           |                               X        X                       X     X   |             
      Duct, Hyperplasia, Atypical          | 3                                                                        |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                               2                       1                  |             
      Granuloma                            |                                                                          |             
      Inflammation, Chronic                |          3                    2                                          |             
      Parasite External                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Periosteum, Inflammation,            |                                                                          |             
          Granulomatous                    |                                                 1                        |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                            +                                             |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   9                                                               
NTP Experiment-Test: 05705-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 12:50:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 6| 6| 7|             
                             DAY ON TEST   | 1| 3| 3| 2| 3| 3| 2| 3| 2| 3| 2| 2| 3| 8| 3| 3| 2| 3| 2| 2| 2| 3| 5| 3| 3|             
                                           | 1| 1| 1| 2| 0| 1| 9| 0| 4| 0| 9| 9| 1| 7| 0| 0| 9| 1| 9| 7| 9| 0| 7| 6| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Compression                          |                                                                          |             
      Hemorrhage                           |                                                                   3      |             
      Mineralization                       | 2  2  1  2  1  2                             1     2  2  1  2        2  2|             
      Necrosis, Focal                      |                                                                          |             
      Pigmentation, Cholesterol            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                      2   |             
      Hemorrhage                           |                            1                                      3      |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                                                          |             
      Artery, Mineralization               |                                                                1         |             
      Artery, Media, Hypertrophy           |                                                 2              1         |             
      Perivascular, Infiltration Cellular, |                                                                          |             
           Lymphocyte                      |                   1        1     1           1  1                       2|             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                   4      |             
      Exudate                              |    1                                      2                              |             
      Granuloma                            |                                                       1                  |             
      Inflammation, Acute                  |       2                                      1           1           2   |             
      Inflammation, Chronic Active         |                      1           1                                       |             
      Mucosa, Nasopharyngeal Duct,         |                                                                          |             
          Hyperplasia                      |                               3                                          |             
      Mucosa, Nasolacrimal Duct,           |                                                                          |             
          Hyperplasia                      |       1     1     1  1     2                 1  3           2  3  2     4|             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Acute                           |                1                                                         |             
      Olfactory Epithelium, Metaplasia     |             2                                                            |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                           +                              |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                +                                                         |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hydronephrosis                       |                                                                          |             
      Inflammation, Chronic                | 1           1                             2  1                       3  2|             
      Nephropathy                          |       2                                         1        4  1  2         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  10                                                               
NTP Experiment-Test: 05705-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 12:50:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7| 6| 6| 7|             
                             DAY ON TEST   | 1| 3| 3| 2| 3| 3| 2| 3| 2| 3| 2| 2| 3| 8| 3| 3| 2| 3| 2| 2| 2| 3| 5| 3| 3|             
                                           | 1| 1| 1| 2| 0| 1| 9| 0| 4| 0| 9| 9| 1| 7| 0| 0| 9| 1| 9| 7| 9| 0| 7| 6| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ureter                                  |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Inflammation, Chronic                |                                  3                          3           3|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  11                                                               
NTP Experiment-Test: 05705-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 12:50:12  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 3| 2| 2| 2| 3| 3| 3| 2| 1|                                            |            |
                                           | 1| 1| 9| 5| 9| 1| 0| 0| 9| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    CONTROL                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  A  +  +  +  +  +  +                                             |  55        |
      Calculus Micro Observation Only      |       X                                                                  |      1     |
      Epithelium, Hyperplasia              |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  A  +  +  +  +  +  +  +                                             |  52        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Parasite Metazoan                    |          X                 X                                             |      6     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hemorrhage                           |    2                                                                     |      2  2.0|
      Inflammation, Acute, Focal           |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  A  A  +  +  +  +  +  +                                             |  53        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  A  A  +  +  +  +  +  +                                             |  51        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  A  A  +  +  +  +  +  +                                             |  52        |
      Amyloid Deposition                   |             3                                                            |      1  3.0|
      Congestion                           |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  A  A  +  +  +  +  +  +                                             |  52        |
      Peyer's Patch, Hyperplasia, Lymphoid |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inflammation, Acute                  |                                                                          |      1  1.0|
      Inflammation, Chronic                |                                                                          |      6  1.5|
      Necrosis, Coagulative                |                                                                          |      3  3.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               | +     +  +        +     +                                                |  23        |
      Inflammation, Chronic                |                         2                                                |     11  1.6|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Atrophy                              |                   3                                                      |      2  3.0|
      Inflammation, Chronic                |                                                                          |      1  3.0|
      Duct, Cyst                           |                   X                                                      |      2     |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Diverticulum                         |                                                                          |      1  2.0|
      Hyperplasia, Focal, Squamous         |                2                                                         |      5  1.8|
      Ulcer                                |             1                                                            |      2  1.5|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  57        |
      Erosion                              |          1                                                               |      3  1.3|
      Hyperplasia, Cystic                  |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |    +                                                                     |   2        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  12                                                               
NTP Experiment-Test: 05705-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 12:50:12  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 3| 2| 2| 2| 3| 3| 3| 2| 1|                                            |            |
                                           | 1| 1| 9| 5| 9| 1| 0| 0| 9| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    CONTROL                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +     +  M  +  +  +  +  +  +                                             |  57        |
      Inflammation, Acute                  |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Degeneration                         |             1              2                                             |      3  1.7|
      Mineralization                       |       1                                                                  |      1  1.0|
      Valve, Pigmentation                  |                         3                                                |      8  1.8|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Basophilic Focus                     |                                                                          |      1     |
      Hematopoietic Cell Proliferation     |                                                                          |            |
          Granulocytic                     |                            X                                             |      1     |
      Inflammation, Chronic                |                                                                          |      1  1.0|
      Necrosis                             |                                                                          |      1  2.0|
      Subcapsular, Hyperplasia             | 2  2  2  3  3  2  3  3  2  3                                             |     59  2.8|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +                                             |  57        |
      Hyperplasia, Focal                   |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  M  M  +  +  +  M  +  M  +                                             |  34        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  M  +  +  +  +  +  +  +  +                                             |  55        |
      Cyst                                 |                            X                                             |      5     |
      Hyperplasia, Focal                   | 1              2     2     3                                             |     16  2.3|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cyst                                 |                            X                                             |      1     |
      Inflammation, Acute, Focal           |                                                                          |      1  1.0|
      Inflammation, Chronic                |                                                                          |      2  1.0|
      Pigmentation, Cholesterol            |                                                                          |      1  2.0|
      Follicle, Cyst                       |                                                                          |      9     |
      Follicular Cell, Hyperplasia         |                         1                                                |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Cyst                                 | X        X        X     X                                                |     24     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  13                                                               
NTP Experiment-Test: 05705-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 12:50:12  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 3| 2| 2| 2| 3| 3| 3| 2| 1|                                            |            |
                                           | 1| 1| 9| 5| 9| 1| 0| 0| 9| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    CONTROL                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Cyst, Multiple                       |                X           X                                             |     11     |
      Inflammation, Chronic                |                         3                                                |      2  3.5|
      Mineralization                       |                                                                          |      1  2.0|
      Artery, Amyloid Deposition           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Oviduct                                 |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Endometrium, Hyperplasia, Cystic     | 2  2     1  2  2  2  3  4  2                                             |     56  2.4|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Myelofibrosis                        | 1  1              1  2  2  3                                             |     26  1.7|
      Myeloid Cell, Hyperplasia            |          3                 3                                             |      3  2.7|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Iliac, Hyperplasia, Plasma Cell      |                            3                                             |      1  3.0|
      Iliac, Inflammation, Acute           |                            2                                             |      1  2.0|
      Mandibular, Abscess                  |          4                                                               |      1  4.0|
      Mandibular, Hyperplasia, Lymphoid    |                                                                          |      2  3.0|
      Mediastinal, Hemorrhage              |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hemorrhage                           |                                                                          |      1  3.0|
      Hyperplasia, Lymphoid                |                                                                          |      3  2.0|
      Inflammation, Acute                  |                            3                                             |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Granuloma, Multiple                  |                                                                          |      1  3.0|
      Hematopoietic Cell Proliferation     |                                                                          |            |
          Granulocytic                     |          X                 X                                             |      3     |
      Hematopoietic Cell Proliferation     |                                                                          |            |
          Erythrocytic                     |                                                                          |      2  3.5|
      Hyperplasia, Lymphoid                |                                                                          |      9  3.0|
      Hyperplasia, Plasma Cell             |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  M  +  +  +  +  +  +  +                                             |  54        |
      Abscess, Multifocal                  |          4                                                               |      1  4.0|
      Atrophy                              |                                                                          |      5  2.2|
      Cyst                                 |                                                                          |      8     |
      Hyperplasia, Lymphoid                |             3                                                            |      1  3.0|
      Inflammation, Acute                  |                            3                                             |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  A  +  +  +  +  +  +  +                                             |  59        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  14                                                               
NTP Experiment-Test: 05705-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 12:50:12  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 3| 2| 2| 2| 3| 3| 3| 2| 1|                                            |            |
                                           | 1| 1| 9| 5| 9| 1| 0| 0| 9| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    CONTROL                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Chronic                |                         1                                                |      4  1.0|
      Acinus, Hyperplasia                  |                                                                          |      1  3.0|
      Duct, Cyst                           |                                                                          |      4     |
      Duct, Hyperplasia, Atypical          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Acanthosis                           |                                                                          |      5  1.8|
      Granuloma                            |                                                                          |      1  1.0|
      Inflammation, Chronic                |                                                                          |      3  2.0|
      Parasite External                    |       X              X                                                   |      3     |
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Periosteum, Inflammation,            |                                                                          |            |
          Granulomatous                    |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                            +                                             |   3        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Compression                          |                                                                          |      1  2.0|
      Hemorrhage                           |                                                                          |      1  3.0|
      Mineralization                       |    2     2     2     2                                                   |     29  1.8|
      Necrosis, Focal                      |                                                                          |      1  2.0|
      Pigmentation, Cholesterol            |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Congestion                           |                                                                          |      1  2.0|
      Hemorrhage                           |                                                                          |      3  1.7|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |                                                                          |      2  2.5|
      Artery, Mineralization               |                                                                          |      1  1.0|
      Artery, Media, Hypertrophy           |                                                                          |      6  1.3|
      Perivascular, Infiltration Cellular, |                                                                          |            |
           Lymphocyte                      |                                                                          |      8  1.3|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Congestion                           |                                                                          |      2  4.0|
      Exudate                              |                         1  1                                             |      9  1.1|
      Granuloma                            |                                                                          |      1  1.0|
      Inflammation, Acute                  |                                                                          |      5  1.4|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  15                                                               
NTP Experiment-Test: 05705-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 12:50:12  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 3| 2| 2| 2| 3| 3| 3| 2| 1|                                            |            |
                                           | 1| 1| 9| 5| 9| 1| 0| 0| 9| 7|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|                                            |      A     |
    CONTROL                                | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|                                            |      L     |
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Inflammation, Chronic Active         |                                                                          |      2  1.0|
      Mucosa, Nasopharyngeal Duct,         |                                                                          |            |
          Hyperplasia                      |                                                                          |      1  3.0|
      Mucosa, Nasolacrimal Duct,           |                                                                          |            |
          Hyperplasia                      | 1  1  3     1     2  2  2  1                                             |     32  1.6|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Acute                           |                                                                          |      1  1.0|
      Olfactory Epithelium, Metaplasia     |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                                                                          |   2        |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cyst                                 |                                                                          |      1     |
      Hydronephrosis                       |                            2                                             |      1  2.0|
      Inflammation, Chronic                | 2                       2                                                |     17  1.5|
      Nephropathy                          |                                                                          |     11  1.7|
                                            __________________________________________________________________________|____________|
   Ureter                                  |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  57        |
      Inflammation, Chronic                |                                                                          |      4  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  16                                                               
NTP Experiment-Test: 05705-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 12:50:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 6| 7| 7| 7| 7| 5| 7| 6| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 3| 7| 5| 7| 7|             
                             DAY ON TEST   | 0| 0| 9| 3| 0| 3| 3| 9| 3| 1| 8| 2| 3| 2| 0| 3| 2| 3| 2| 3| 9| 3| 9| 3| 3|             
                                           | 3| 3| 7| 0| 9| 0| 0| 1| 0| 4| 7| 9| 6| 9| 1| 1| 9| 1| 9| 0| 0| 1| 0| 1| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    50 MG/KG                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
     FEMALE                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Gallbladder                             |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         |                                                       +                  |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |                                                       +                  |             
      Peyer's Patch, Hyperplasia, Lymphoid |                                                       3                  |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                                          |             
          Granulocytic                     |                               1                                          |             
      Inflammation, Acute                  |    3                                                                     |             
      Inflammation, Chronic                |                   1  1                 1     2  1              1        1|             
      Inflammation, Chronic Active         |                                                             1            |             
      Necrosis, Coagulative                |    2                                                                     |             
      Pigmentation                         |                                                             3            |             
      Hepatocyte, Necrosis                 |                               1                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               | +           +                    +                                       |             
      Inflammation, Chronic                |                                  2                                       |             
      Artery, Adventitia, Inflammation,    |                                                                          |             
           Chronic Active                  |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                      X   |             
      Hyperplasia, Focal, Squamous         |                   2                    1                 1               |             
      Inflammation, Chronic                |                                                 2                        |             
      Ulcer, Multifocal                    |                                                                          |             
      Vein, Dilatation                     |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                   1      |             
      Inflammation, Chronic                |                                                                          |             
      Mineralization                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration                         |                                                                          |             
      Inflammation, Chronic                |                                                 1                        |             
      Valve, Pigmentation                  |                   2  1        1  1     1        2  1     1  1           2|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +                                                                        |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +                                                                        |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  17                                                               
NTP Experiment-Test: 05705-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 12:50:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 6| 7| 7| 7| 7| 5| 7| 6| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 3| 7| 5| 7| 7|             
                             DAY ON TEST   | 0| 0| 9| 3| 0| 3| 3| 9| 3| 1| 8| 2| 3| 2| 0| 3| 2| 3| 2| 3| 9| 3| 9| 3| 3|             
                                           | 3| 3| 7| 0| 9| 0| 0| 1| 0| 4| 7| 9| 6| 9| 1| 1| 9| 1| 9| 0| 0| 1| 0| 1| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    50 MG/KG                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
     FEMALE                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +           +  +                       +     +     +           +     +   |             
      Cyst                                 |                X                             X                 X     X   |             
      Cyst, Multiple                       |                                        X           X                     |             
      Inflammation, Acute                  |                                                                          |             
      Mineralization                       |                                              1                           |             
                                            __________________________________________________________________________|             
   Uterus                                  |       +  +  +  +  +     +        +  +  +     +     +  +  +     +     +  +|             
      Inflammation, Acute                  |                                                                          |             
      Endometrium, Hyperplasia, Cystic     |       1  2  2  2  2     2        2  2  2     3     2  3  2     2     2  2|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |             +     +     +        +           +  +              +     +   |             
      Myelofibrosis                        |             2     1     2        1           2  2              1     2   |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +           +  +     +     +  +     +     +                 +            |             
      Iliac, Hyperplasia, Plasma Cell      |                                                                          |             
      Mediastinal, Hyperplasia, Plasma Cell|                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +           +  +     +     +  +     +                       +            |             
                                            __________________________________________________________________________|             
   Spleen                                  |    +        +  +     +     +        +     +  +  +           +  +  +     +|             
      Fibrosis                             |                                                                1         |             
      Hematopoietic Cell Proliferation     |                                                                          |             
          Granulocytic                     |    X                                                                     |             
      Hematopoietic Cell Proliferation     |                                                                          |             
          Erythrocytic                     |             X                                                            |             
      Hyperplasia, Lymphoid                |                                              3  4                       4|             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  |                      +     +                                             |             
      Cyst                                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |                                           +     +                        |             
      Duct, Cyst                           |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +     +  +  +  +  +  +  +     +     +     +  +  +  +  +  +  +        +  +|             
      Acanthosis                           |                                                       2                  |             
      Infiltration Cellular, Mast Cell     |                                              2                           |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |                         1                             1                  |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |                                           +                              |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         | +                                                                        |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |                                                                          |             
      Mineralization                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  18                                                               
NTP Experiment-Test: 05705-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 12:50:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 6| 7| 7| 7| 7| 5| 7| 6| 5| 7| 6| 7| 7| 7| 7| 7| 7| 7| 3| 7| 5| 7| 7|             
                             DAY ON TEST   | 0| 0| 9| 3| 0| 3| 3| 9| 3| 1| 8| 2| 3| 2| 0| 3| 2| 3| 2| 3| 9| 3| 9| 3| 3|             
                                           | 3| 3| 7| 0| 9| 0| 0| 1| 0| 4| 7| 9| 6| 9| 1| 1| 9| 1| 9| 0| 0| 1| 0| 1| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    50 MG/KG                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
     FEMALE                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |    +                       +        +  +  +              +  +     +      |             
      Congestion                           |                                                             2            |             
      Inflammation, Chronic                |                                                          1               |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                        2                                 |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                                                                          |             
      Perivascular, Infiltration Cellular, |                                                                          |             
           Lymphocyte                      |                                        1                                 |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Concretion                           |                                                                          |             
      Exudate                              |       1        1        1  2                             1     1         |             
      Inflammation, Acute                  |    1     1  1     2  2              1     1     1     1                  |             
      Inflammation, Chronic                |                                                          1               |             
      Inflammation, Chronic Active         |                         1                                                |             
      Mucosa, Nasolacrimal Duct,           |                                                                          |             
          Hyperplasia                      |       2           1     1              1  1  1  1     1  1  1  1  1  1  1|             
      Olfactory Epithelium, Metaplasia     |          1              1                    1                 2         |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                             +            |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |             +              +                                             |             
                                            __________________________________________________________________________|             
   Ureter                                  | +                                                                        |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  19                                                               
NTP Experiment-Test: 05705-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 12:50:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 2| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 6| 7| 3| 5| 7| 7| 7|             
                             DAY ON TEST   | 3| 5| 3| 2| 3| 4| 3| 2| 3| 2| 3| 3| 2| 3| 7| 2| 4| 3| 5| 3| 1| 4| 3| 3| 2|             
                                           | 1| 3| 0| 9| 0| 5| 1| 9| 0| 9| 1| 0| 9| 1| 5| 9| 0| 0| 6| 1| 0| 5| 1| 0| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    50 MG/KG                               | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
     FEMALE                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Gallbladder                             |                A              +                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |                                                                          |             
      Peyer's Patch, Hyperplasia, Lymphoid |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                                          |             
          Granulocytic                     |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |             1                    1  1                             1  2   |             
      Inflammation, Chronic Active         |                                                                          |             
      Necrosis, Coagulative                |                                                                          |             
      Pigmentation                         |                                                                          |             
      Hepatocyte, Necrosis                 |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                      +        +                                   +      |             
      Inflammation, Chronic                |                                                                          |             
      Artery, Adventitia, Inflammation,    |                                                                          |             
           Chronic Active                  |                                                                   2      |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hyperplasia, Focal, Squamous         |                                        1                          3  3  3|             
      Inflammation, Chronic                |                                                                      3   |             
      Ulcer, Multifocal                    | 2                                                                        |             
      Vein, Dilatation                     |                                                    1                     |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                               1                                          |             
      Inflammation, Chronic                |                                                                          |             
      Mineralization                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |                                                                   +      |             
      Inflammation, Chronic Active         |                                                                   2      |             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration                         |                   2                          1                           |             
      Inflammation, Chronic                |                                                                          |             
      Valve, Pigmentation                  | 1           1     3     2        1  2              1        1            |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |       +                                   +                          +   |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |          +                                                               |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  20                                                               
NTP Experiment-Test: 05705-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 12:50:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 2| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 6| 7| 3| 5| 7| 7| 7|             
                             DAY ON TEST   | 3| 5| 3| 2| 3| 4| 3| 2| 3| 2| 3| 3| 2| 3| 7| 2| 4| 3| 5| 3| 1| 4| 3| 3| 2|             
                                           | 1| 3| 0| 9| 0| 5| 1| 9| 0| 9| 1| 0| 9| 1| 5| 9| 0| 0| 6| 1| 0| 5| 1| 0| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    50 MG/KG                               | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
     FEMALE                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   |    +        +     +     +                 +  +  +           +            |             
      Cyst                                 |             X     X     X                                   X            |             
      Cyst, Multiple                       |                                                 X                        |             
      Inflammation, Acute                  |                                                                          |             
      Mineralization                       |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +     +  +  +     +     +  +     +     +  +  +  +  +  +  +  +        +  +|             
      Inflammation, Acute                  |                                                          2  4            |             
      Endometrium, Hyperplasia, Cystic     | 4     1  2  2     4     2  2     3     3     3  2  3  2  3           1  2|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |       +  +  +     +     +  +        +  +                 +               |             
      Myelofibrosis                        |       1  4  2     2     2  2        2  2                 1               |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +        +     +     +              +     +                    +        +|             
      Iliac, Hyperplasia, Plasma Cell      |                                                                          |             
      Mediastinal, Hyperplasia, Plasma Cell|                                     2                                    |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |          +           +                    +                    +         |             
                                            __________________________________________________________________________|             
   Spleen                                  |          +           +     +  +           +     +     +        +        +|             
      Fibrosis                             |                                           2                              |             
      Hematopoietic Cell Proliferation     |                                                                          |             
          Granulocytic                     |                                                       X                  |             
      Hematopoietic Cell Proliferation     |                                                                          |             
          Erythrocytic                     |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Pigmentation                         |                                           2                              |             
                                            __________________________________________________________________________|             
   Thymus                                  |                                           +                              |             
      Cyst                                 |                                           X                              |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +                                         +                              |             
      Duct, Cyst                           |                                           X                              |             
                                            __________________________________________________________________________|             
   Skin                                    | +     +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +     +  +  +  +|             
      Acanthosis                           |                                     2                                    |             
      Infiltration Cellular, Mast Cell     |                                                                          |             
      Inflammation, Acute                  |                                     2                                    |             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                           +                              |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |                                           +                              |             
      Mineralization                       |                                           2                              |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  21                                                               
NTP Experiment-Test: 05705-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 12:50:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 2| 7| 7| 7| 5| 7| 7| 7| 7| 7| 7| 7| 7| 6| 7| 6| 7| 6| 7| 3| 5| 7| 7| 7|             
                             DAY ON TEST   | 3| 5| 3| 2| 3| 4| 3| 2| 3| 2| 3| 3| 2| 3| 7| 2| 4| 3| 5| 3| 1| 4| 3| 3| 2|             
                                           | 1| 3| 0| 9| 0| 5| 1| 9| 0| 9| 1| 0| 9| 1| 5| 9| 0| 0| 6| 1| 0| 5| 1| 0| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    50 MG/KG                               | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
     FEMALE                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |       +  +     +                    +     +     +                        |             
      Congestion                           |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |       4                                                                  |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                                     2                                    |             
      Perivascular, Infiltration Cellular, |                                                                          |             
           Lymphocyte                      |                                     3                                    |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Concretion                           |                                                                         1|             
      Exudate                              | 1                          1     1                 1        1            |             
      Inflammation, Acute                  |    1  1                             1                                1   |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         |                                                                   1      |             
      Mucosa, Nasolacrimal Duct,           |                                                                          |             
          Hyperplasia                      | 1     2           1        2     1  1        1  1  1  1  2  1     1     3|             
      Olfactory Epithelium, Metaplasia     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |                      +                    +                    +         |             
                                            __________________________________________________________________________|             
   Ureter                                  |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |                                           +                              |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  22                                                               
NTP Experiment-Test: 05705-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 12:50:12  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 6| 7| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 5| 3| 2| 4| 2| 2| 3| 3| 2| 3|                                            |            |
                                           | 1| 1| 9| 7| 9| 9| 1| 0| 9| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    50 MG/KG                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |      L     |
     FEMALE                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Gallbladder                             |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |                                                                          |   1        |
      Peyer's Patch, Hyperplasia, Lymphoid |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hematopoietic Cell Proliferation     |                                                                          |            |
          Granulocytic                     |                                                                          |      1  1.0|
      Inflammation, Acute                  |                                                                          |      1  3.0|
      Inflammation, Chronic                |       1        1  1  1     3                                             |     17  1.2|
      Inflammation, Chronic Active         |                                                                          |      1  1.0|
      Necrosis, Coagulative                |                                                                          |      1  2.0|
      Pigmentation                         |                                                                          |      1  3.0|
      Hepatocyte, Necrosis                 |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |             +                                                            |   7        |
      Inflammation, Chronic                |             3                                                            |      2  2.5|
      Artery, Adventitia, Inflammation,    |                                                                          |            |
           Chronic Active                  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Cyst                                 |                                                                          |      1     |
      Hyperplasia, Focal, Squamous         |       3                                                                  |      8  2.1|
      Inflammation, Chronic                |       2                                                                  |      3  2.3|
      Ulcer, Multifocal                    |                                                                          |      1  2.0|
      Vein, Dilatation                     |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Erosion                              |                                                                          |      2  1.0|
      Inflammation, Chronic                | 2                                                                        |      1  2.0|
      Mineralization                       |                   1                                                      |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |                                                                          |   1        |
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Degeneration                         |                                                                          |      2  1.5|
      Inflammation, Chronic                |                                                                          |      1  1.0|
      Valve, Pigmentation                  |                      1     1                                             |     20  1.4|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |                                                                          |   1        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  23                                                               
NTP Experiment-Test: 05705-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 12:50:12  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 6| 7| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 5| 3| 2| 4| 2| 2| 3| 3| 2| 3|                                            |            |
                                           | 1| 1| 9| 7| 9| 9| 1| 0| 9| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    50 MG/KG                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |      L     |
     FEMALE                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |             +        +  +                                                |   6        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +     +  +     +  +  +                                             |  24        |
      Cyst                                 |       X        X     X  X                                                |     12     |
      Cyst, Multiple                       |    X        X              X                                             |      6     |
      Inflammation, Acute                  |             2                                                            |      1  2.0|
      Mineralization                       |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  |    +  +  +  +  +  +  +  +  +                                             |  43        |
      Inflammation, Acute                  |             2                                                            |      3  2.7|
      Endometrium, Hyperplasia, Cystic     |    2  3  1  2  2  2  2  2  3                                             |     41  2.2|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |    +     +  +              +                                             |  21        |
      Myelofibrosis                        |    2     2  2              2                                             |     21  1.9|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +              +                                                         |  19        |
      Iliac, Hyperplasia, Plasma Cell      | 3                                                                        |      1  3.0|
      Mediastinal, Hyperplasia, Plasma Cell|                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |                                                                          |  12        |
                                            __________________________________________________________________________|____________|
   Spleen                                  |             +        +  +                                                |  25        |
      Fibrosis                             |                                                                          |      2  1.5|
      Hematopoietic Cell Proliferation     |                                                                          |            |
          Granulocytic                     |                                                                          |      2     |
      Hematopoietic Cell Proliferation     |                                                                          |            |
          Erythrocytic                     |                                                                          |      1     |
      Hyperplasia, Lymphoid                |             4                                                            |      4  3.8|
      Pigmentation                         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  |                                                                          |   3        |
      Cyst                                 |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |                                                                          |   4        |
      Duct, Cyst                           |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  50        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  24                                                               
NTP Experiment-Test: 05705-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 12:50:12  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 6| 7| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 5| 3| 2| 4| 2| 2| 3| 3| 2| 3|                                            |            |
                                           | 1| 1| 9| 7| 9| 9| 1| 0| 9| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    50 MG/KG                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |      L     |
     FEMALE                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Acanthosis                           |                                                                          |      2  2.0|
      Infiltration Cellular, Mast Cell     |                                                                          |      1  2.0|
      Inflammation, Acute                  |                                                                          |      1  2.0|
      Inflammation, Chronic                |                         1                                                |      3  1.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |                                                                          |   1        |
      Mineralization                       |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |                                                                          |  14        |
      Congestion                           |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                                                          |      1  1.0|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |                                                                          |      2  3.0|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |                                                                          |      1  2.0|
      Perivascular, Infiltration Cellular, |                                                                          |            |
           Lymphocyte                      |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Concretion                           |                                                                          |      1  1.0|
      Exudate                              | 1  1           2     1                                                   |     15  1.1|
      Inflammation, Acute                  |                   1     1                                                |     15  1.1|
      Inflammation, Chronic                |                                                                          |      1  1.0|
      Inflammation, Chronic Active         |             2                                                            |      3  1.3|
      Mucosa, Nasolacrimal Duct,           |                                                                          |            |
          Hyperplasia                      | 1        1        1        2                                             |     32  1.2|
      Olfactory Epithelium, Metaplasia     |                      1                                                   |      5  1.2|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |                                                                          |   5        |
                                            __________________________________________________________________________|____________|
   Ureter                                  |                                                                          |   1        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  25                                                               
NTP Experiment-Test: 05705-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 12:50:12  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 6| 7| 7| 6| 7| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 5| 3| 2| 4| 2| 2| 3| 3| 2| 3|                                            |            |
                                           | 1| 1| 9| 7| 9| 9| 1| 0| 9| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|                                            |      A     |
    50 MG/KG                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|                                            |      L     |
     FEMALE                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |                                                                          |   1        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  26                                                               
NTP Experiment-Test: 05705-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 12:50:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1| 1| 1| 7| 7|             
                             DAY ON TEST   | 6| 3| 3| 3| 3| 2| 2| 3| 2| 2| 9| 3| 1| 2| 2| 3| 3| 3| 3| 2| 3| 8| 8| 2| 3|             
                                           | 6| 0| 0| 1| 1| 9| 5| 0| 9| 9| 1| 0| 7| 9| 9| 1| 0| 1| 0| 9| 7| 2| 2| 9| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    100MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     FEMALE                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | M  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  M  +  +  M  M  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | A  +  +  +  +  +  +  +  +  +  M  +  A  +  +  +  +  +  +  +  A  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                     X                                    |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +|             
      Ulcer, Acute                         |       3                                                                  |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | A  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  A  A  +  +  +|             
      Amyloid Deposition                   |                                                                          |             
      Inflammation, Acute                  |                                     2                                    |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  A  +  +  +|             
      Ulcer, Acute                         |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
          Granulocytic                     |                   X                 2                                    |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |    2        1                             2     2  2                    3|             
      Inflammation, Chronic Active         |                         1                                                |             
      Bile Duct, Hyperplasia               |                                                                      2   |             
                                            __________________________________________________________________________|             
   Mesentery                               |       +           +              +                 +  +                 +|             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |       2                                            3  2                 2|             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                      3   |             
      Clear Cell Focus                     |                                                                X         |             
      Inflammation, Chronic                |                                                                         2|             
      Duct, Cyst                           |                                                                      X   |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                    3                     |             
      Mucocele                             |                                        X                                 |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                                                          2              2|             
      Hyperplasia, Diffuse, Squamous       |       3                                                                  |             
      Hyperplasia, Focal, Squamous         |          2  2        2           1                 2                     |             
      Hyperplasia, Multifocal, Squamous    |    2                                                                    2|             
      Inflammation, Acute                  |                                                                         1|             
      Inflammation, Acute, Multifocal      |                                                                          |             
      Inflammation, Chronic                |       2           2                                                      |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  27                                                               
NTP Experiment-Test: 05705-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 12:50:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1| 1| 1| 7| 7|             
                             DAY ON TEST   | 6| 3| 3| 3| 3| 2| 2| 3| 2| 2| 9| 3| 1| 2| 2| 3| 3| 3| 3| 2| 3| 8| 8| 2| 3|             
                                           | 6| 0| 0| 1| 1| 9| 5| 0| 9| 9| 1| 0| 7| 9| 9| 1| 0| 1| 0| 9| 7| 2| 2| 9| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    100MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     FEMALE                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Ulcer                                |                                                                          |             
      Ulcer, Multifocal                    |       2                                                                  |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                               2                                   1      |             
      Hyperplasia, Atypical, Focal         |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                   +                          +                           |             
      Developmental Malformation           |                                              X                           |             
      Peridontal Tissue, Cyst              |                                              X                           |             
      Peridontal Tissue, Inflammation,     |                                                                          |             
           Acute                           |                   2                                                      |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration                         |                   1                 1                                    |             
      Mineralization                       |                                                                          |             
      Coronary Artery, Inflammation,       |                                                                          |             
          Chronic                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |       1                                                                  |             
      Fibrosis, Focal                      |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
          Granulocytic                     |                   X                 X                                    |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia                          |    2                                                                     |             
      Hypertrophy                          |             2                                         3                  |             
      Necrosis                             |                                  2                                       |             
      Subcapsular, Hyperplasia             |    3  3  3  3  3  3  3  3  3  2  2  3  3  3  3  3  3  3  2  1  2  3  3  3|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  +  M  M  +  +  +  +  +  M  M  +  M  +  +  +  +  +  M  M  +  +  +  +|             
      Cyst                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                            X           X                                 |             
      Hyperplasia, Focal                   |          3           3     2                 3  3                       2|             
      Hypertrophy, Focal                   |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |             1                                                        1   |             
      Follicle, Cyst                       |                                     X                                    |             
      Follicular Cell, Hyperplasia         |                                  2     3        2                        |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  28                                                               
NTP Experiment-Test: 05705-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 12:50:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1| 1| 1| 7| 7|             
                             DAY ON TEST   | 6| 3| 3| 3| 3| 2| 2| 3| 2| 2| 9| 3| 1| 2| 2| 3| 3| 3| 3| 2| 3| 8| 8| 2| 3|             
                                           | 6| 0| 0| 1| 1| 9| 5| 0| 9| 9| 1| 0| 7| 9| 9| 1| 0| 1| 0| 9| 7| 2| 2| 9| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    100MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     FEMALE                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |                                                                          |             
      Cyst                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                   4                                                      |             
      Cyst                                 |    X  X     X     X     X              X     X     X              X  X   |             
      Cyst, Multiple                       |                X     X           X              X                        |             
      Inflammation, Acute                  |    3                                                                     |             
      Mineralization                       |    2                                                           1         |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                   4                                                      |             
      Inflammation, Acute                  |                                                                          |             
      Thrombosis                           |                                                 2                        |             
      Endometrium, Hyperplasia, Cystic     |    3  3  3  2  3     2  2  2     3     2  3  2  3  3  3  2           2  2|             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Myelofibrosis                        |    3           2     2     1           1        2     2                 1|             
      Myeloid Cell, Hyperplasia            |                   4                 4                                    |             
                                            __________________________________________________________________________|             
   Lymph Node                              | A  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Iliac, Fibrosis                      |                                                                          |             
      Iliac, Hematopoietic Cell            |                                                                          |             
          Proliferation Granulocytic       |                                                                          |             
      Iliac, Inflammation, Acute           |          2                                                               |             
      Iliac, Inflammation, Chronic Active  |                   4                                                      |             
      Iliac, Pigmentation                  |                                                                          |             
      Inguinal, Inflammation, Acute        |                   2                                                      |             
      Mandibular, Hyperplasia, Lymphoid    |                                                    3                     |             
      Mediastinal, Hyperplasia, Lymphoid   |       3                                                                  |             
      Pancreatic, Inflammation, Acute      |                   4                                                      |             
      Renal, Inflammation, Acute           |                   3                                                      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | A  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                                          |             
          Granulocytic                     |                                     1                                    |             
      Hyperplasia, Lymphoid                |                                                                         4|             
      Inflammation, Granulomatous          |                                                                      3   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                                          |             
          Granulocytic                     |                   4                 4                                    |             
      Hematopoietic Cell Proliferation     |                                                                          |             
          Erythrocytic                     |          3                                                               |             
      Hyperplasia, Lymphoid                |    3  3                 2                 2  3     4  3                 2|             
      Hyperplasia, Plasma Cell             |                                                                          |             
      Inflammation, Granulomatous          |                                                                      2   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  29                                                               
NTP Experiment-Test: 05705-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 12:50:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1| 1| 1| 7| 7|             
                             DAY ON TEST   | 6| 3| 3| 3| 3| 2| 2| 3| 2| 2| 9| 3| 1| 2| 2| 3| 3| 3| 3| 2| 3| 8| 8| 2| 3|             
                                           | 6| 0| 0| 1| 1| 9| 5| 0| 9| 9| 1| 0| 7| 9| 9| 1| 0| 1| 0| 9| 7| 2| 2| 9| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    100MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     FEMALE                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  M|             
      Atrophy                              |                                                                          |             
      Cyst                                 |                                           X        X              X  X   |             
      Necrosis                             |                               2                                   2      |             
      Pigmentation, Lipofuscin             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis, Focal                      |                                                    2                     |             
      Hemorrhage                           |                                                                          |             
      Duct, Cyst                           |                                        X                                 |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |       2                                                                  |             
      Fibrosis                             |                                                                          |             
      Hyperkeratosis                       |                                                       2                  |             
      Inflammation, Acute, Chronic         |       1                                                                  |             
      Inflammation, Chronic                |                                                                          |             
      Parasite External                    |                                                                          |             
      Ulcer, Acute                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Edema                                |                                                                          |             
      Fibrosis                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Mineralization                       |    2  2  2  2        1  1                    2                       2   |             
                                            __________________________________________________________________________|             
   Spinal Cord                             | +                                                                        |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           | 3                                                                        |             
      Hemorrhage                           |    1                                                                     |             
      Inflammation, Acute, Focal           | 1                                                                        |             
      Inflammation, Chronic                |                                                                          |             
      Alveolus, Crystals                   |                         1                                                |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                         2                          2                     |             
      Artery, Media, Hypertrophy           |       1                                                        2        1|             
      Bronchus, Fibrosis                   | 2                                                                        |             
      Interstitium, Fibrosis, Multifocal   | 2                                                                        |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  30                                                               
NTP Experiment-Test: 05705-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 12:50:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 0| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1| 7| 7| 7| 7| 7| 7| 7| 7| 7| 1| 1| 1| 7| 7|             
                             DAY ON TEST   | 6| 3| 3| 3| 3| 2| 2| 3| 2| 2| 9| 3| 1| 2| 2| 3| 3| 3| 3| 2| 3| 8| 8| 2| 3|             
                                           | 6| 0| 0| 1| 1| 9| 5| 0| 9| 9| 1| 0| 7| 9| 9| 1| 0| 1| 0| 9| 7| 2| 2| 9| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    100MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     FEMALE                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Interstitium, Inflammation, Chronic, |                                                                          |             
           Focal                           |                                                                          |             
      Perivascular, Infiltration Cellular, |                                                                          |             
           Lymphocyte                      |       3     2  1     2                       2  1  1  1        1        3|             
      Pleura, Inflammation, Acute, Focal   |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                    X                     |             
      Exudate                              | 2                             2  2                          2     2  1   |             
      Granuloma                            |                                                    2                     |             
      Inflammation, Acute                  |       1  2  1  2  2     1  2           1  1  2     3  2  1              1|             
      Inflammation, Chronic Active         |                                                                          |             
      Mucosa, Nasolacrimal Duct,           |                                                                          |             
          Hyperplasia                      |          1  1  2  1     2  1     2     1        2     2  1        2  1  1|             
      Nasolacrimal Duct, Hyperplasia       |                                                    2                     |             
      Olfactory Epithelium, Metaplasia     |                   2                       3  3        2                  |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  | 2                                                                        |             
      Metaplasia, Squamous                 |                                                                         2|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                        +                                 |             
      Cornea, Inflammation, Chronic        |                                        4                                 |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |    2     1  2                       2     2     2  2  2                 2|             
      Mineralization                       |                                                                          |             
      Nephropathy                          |       2           1  1     2     1                                   1   |             
      Renal Tubule, Epithelium,            |                                                                          |             
          Pigmentation                     |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |       2                                                                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  31                                                               
NTP Experiment-Test: 05705-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 12:50:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 1| 7| 6| 7| 7| 0| 1| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 8| 2| 2| 3| 2| 0| 3| 6| 3| 3| 3| 8| 3| 2| 3| 2| 7| 4| 2| 2| 3| 3| 3| 3| 3|             
                                           | 4| 3| 9| 1| 9| 0| 0| 4| 1| 0| 2| 2| 0| 9| 0| 9| 2| 0| 9| 9| 0| 1| 0| 0| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    100MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
     FEMALE                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  A  +  +  +  +  +  A  +  M  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | A  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                X        X|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer, Acute                         |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | A  +  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  A  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                      3                                                   |             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | A  A  +  +  +  +  +  +  +  +  A  A  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer, Acute                         |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |          4                                                               |             
      Hematopoietic Cell Proliferation     |                                                                          |             
          Granulocytic                     | 4  2                                                                     |             
      Inflammation, Acute                  |    2                                                                     |             
      Inflammation, Chronic                |       2     1     1  2                 2                    2  3         |             
      Inflammation, Chronic Active         |                                                                          |             
      Bile Duct, Hyperplasia               |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               | +     +     +     +     +                       +           +  +         |             
      Inflammation, Acute                  | 4                                                                        |             
      Inflammation, Chronic                |       2           3                                         2  2         |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                3     4  1|             
      Clear Cell Focus                     |                                                                          |             
      Inflammation, Chronic                |                   2                                            2         |             
      Duct, Cyst                           |                                        X                                 |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                        2                                 |             
      Mucocele                             |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperkeratosis                       |                         2                                      2         |             
      Hyperplasia, Diffuse, Squamous       |                                                                          |             
      Hyperplasia, Focal, Squamous         |       2                                               4                 2|             
      Hyperplasia, Multifocal, Squamous    |                            3                                             |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Acute, Multifocal      |                            2                                             |             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  32                                                               
NTP Experiment-Test: 05705-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 12:50:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 1| 7| 6| 7| 7| 0| 1| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 8| 2| 2| 3| 2| 0| 3| 6| 3| 3| 3| 8| 3| 2| 3| 2| 7| 4| 2| 2| 3| 3| 3| 3| 3|             
                                           | 4| 3| 9| 1| 9| 0| 0| 4| 1| 0| 2| 2| 0| 9| 0| 9| 2| 0| 9| 9| 0| 1| 0| 0| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    100MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
     FEMALE                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Ulcer                                |                   2                                   2                  |             
      Ulcer, Multifocal                    |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                          |             
      Hyperplasia, Atypical, Focal         |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Developmental Malformation           |                                                                          |             
      Peridontal Tissue, Cyst              |                                                                          |             
      Peridontal Tissue, Inflammation,     |                                                                          |             
           Acute                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration                         | 1  2                 3                                                   |             
      Mineralization                       |                      1                 3        1                        |             
      Coronary Artery, Inflammation,       |                                                                          |             
          Chronic                          |                            2                                             |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                          |             
      Fibrosis, Focal                      |                1                                                         |             
      Hematopoietic Cell Proliferation     |                                                                          |             
          Granulocytic                     | 3                                                                        |             
      Hemorrhage                           |    2                                                                     |             
      Hyperplasia                          |                                                                          |             
      Hypertrophy                          |                   2                                                      |             
      Necrosis                             | 3                                                                        |             
      Subcapsular, Hyperplasia             | 3  3  3  3  3  2  3  3  3  3     2  3  3  2  4  3  3  3  3  3  3  3  3  3|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  +  +  M  +  +  M  +  +  +  +  +  +  M  +  +  +  +  M  +  M  M|             
      Cyst                                 |                         X                                                |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  M  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                X                                                         |             
      Hyperplasia, Focal                   |                                           3              3               |             
      Hypertrophy, Focal                   |                   1                                                      |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Follicle, Cyst                       |                                                                X         |             
      Follicular Cell, Hyperplasia         |                                                       2                  |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  33                                                               
NTP Experiment-Test: 05705-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 12:50:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 1| 7| 6| 7| 7| 0| 1| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 8| 2| 2| 3| 2| 0| 3| 6| 3| 3| 3| 8| 3| 2| 3| 2| 7| 4| 2| 2| 3| 3| 3| 3| 3|             
                                           | 4| 3| 9| 1| 9| 0| 0| 4| 1| 0| 2| 2| 0| 9| 0| 9| 2| 0| 9| 9| 0| 1| 0| 0| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    100MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
     FEMALE                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |                +              +                                          |             
      Cyst                                 |                X                                                         |             
                                            __________________________________________________________________________|             
   Ovary                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              | 4  4                                                                     |             
      Cyst                                 |    X     X  X     X                 X  X  X        X  X  X  X  X         |             
      Cyst, Multiple                       |                         X  X                                         X  X|             
      Inflammation, Acute                  |                                                                          |             
      Mineralization                       |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                                   4      |             
      Inflammation, Acute                  | 1     2                                                                  |             
      Thrombosis                           |                                                                          |             
      Endometrium, Hyperplasia, Cystic     |             3     3  2  3  2        3  3  2  2  3     3  3  2  2  3  2  2|             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                                +        +|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Myelofibrosis                        | 2     2     2              3        1  1  1                 3        1   |             
      Myeloid Cell, Hyperplasia            |    4                                                                     |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Iliac, Fibrosis                      |                                                                         1|             
      Iliac, Hematopoietic Cell            |                                                                          |             
          Proliferation Granulocytic       |                                                                         3|             
      Iliac, Inflammation, Acute           |                                                                          |             
      Iliac, Inflammation, Chronic Active  |                                                                          |             
      Iliac, Pigmentation                  |                                                                         3|             
      Inguinal, Inflammation, Acute        |                                                                          |             
      Mandibular, Hyperplasia, Lymphoid    |                                                                          |             
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |             
      Pancreatic, Inflammation, Acute      |                                                                          |             
      Renal, Inflammation, Acute           |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                                          |             
          Granulocytic                     |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Inflammation, Granulomatous          |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                                          |             
          Granulocytic                     | 4  3                                                                     |             
      Hematopoietic Cell Proliferation     |                                                                          |             
          Erythrocytic                     |                4                                                  3      |             
      Hyperplasia, Lymphoid                |       2  2                             2                    4  4         |             
      Hyperplasia, Plasma Cell             | 4                                                                        |             
      Inflammation, Granulomatous          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  34                                                               
NTP Experiment-Test: 05705-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 12:50:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 1| 7| 6| 7| 7| 0| 1| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 8| 2| 2| 3| 2| 0| 3| 6| 3| 3| 3| 8| 3| 2| 3| 2| 7| 4| 2| 2| 3| 3| 3| 3| 3|             
                                           | 4| 3| 9| 1| 9| 0| 0| 4| 1| 0| 2| 2| 0| 9| 0| 9| 2| 0| 9| 9| 0| 1| 0| 0| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    100MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
     FEMALE                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  M  +  +  +  +  +  +  +|             
      Atrophy                              |                               3                                          |             
      Cyst                                 |          X     X                                                        X|             
      Necrosis                             |                                                                          |             
      Pigmentation, Lipofuscin             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis, Focal                      |                                                                          |             
      Hemorrhage                           |                                                    3                     |             
      Duct, Cyst                           |                                  X              X                        |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                                                          |             
      Fibrosis                             |                                     3                                    |             
      Hyperkeratosis                       |                                                                          |             
      Inflammation, Acute, Chronic         |                                                                          |             
      Inflammation, Chronic                |                         1                                   1            |             
      Parasite External                    |                                                             X            |             
      Ulcer, Acute                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                +                             +                           |             
      Edema                                |                                              3                           |             
      Fibrosis                             |                                              1                           |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                    1                     |             
      Mineralization                       |             2     2  1  1              2  2  1     2  2  3  2           1|             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                               +                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                               3                                          |             
      Hemorrhage                           |                   3                                                      |             
      Inflammation, Acute, Focal           |                      2                                                   |             
      Inflammation, Chronic                |                                                                2         |             
      Alveolus, Crystals                   |                                                                          |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                                                                          |             
      Artery, Media, Hypertrophy           |       2     2        1           2     1  1                              |             
      Bronchus, Fibrosis                   |                                                                          |             
      Interstitium, Fibrosis, Multifocal   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  35                                                               
NTP Experiment-Test: 05705-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 12:50:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 5| 7| 7| 7| 7| 1| 7| 6| 7| 7| 0| 1| 7| 7| 7| 7| 6| 6| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 8| 2| 2| 3| 2| 0| 3| 6| 3| 3| 3| 8| 3| 2| 3| 2| 7| 4| 2| 2| 3| 3| 3| 3| 3|             
                                           | 4| 3| 9| 1| 9| 0| 0| 4| 1| 0| 2| 2| 0| 9| 0| 9| 2| 0| 9| 9| 0| 1| 0| 0| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
    100MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
     FEMALE                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Interstitium, Inflammation, Chronic, |                                                                          |             
           Focal                           |          1                                                               |             
      Perivascular, Infiltration Cellular, |                                                                          |             
           Lymphocyte                      |    3  1           2        1     1  1     2                 2            |             
      Pleura, Inflammation, Acute, Focal   | 3                                                                        |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Exudate                              |                               1        1                    2     1  1   |             
      Granuloma                            |                                                                          |             
      Inflammation, Acute                  | 2           2     1     2        1        1  1  1     2  1     1        1|             
      Inflammation, Chronic Active         |    2  2  2                                         1                     |             
      Mucosa, Nasolacrimal Duct,           |                                                                          |             
          Hyperplasia                      | 1     1  2  1        2     1                 1  1  1  2  2  2  2  2  1  2|             
      Nasolacrimal Duct, Hyperplasia       |                                                                          |             
      Olfactory Epithelium, Metaplasia     |          2  2     1                 2     3  1     2     2     2  2      |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |    2                 2                                                   |             
      Metaplasia, Squamous                 |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Cornea, Inflammation, Chronic        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                | 2  2  2                 1  2                                   3        1|             
      Mineralization                       |                                                                   1      |             
      Nephropathy                          |                   1        2                 1        1                  |             
      Renal Tubule, Epithelium,            |                                                                          |             
          Pigmentation                     |                3                                                         |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  I  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  36                                                               
NTP Experiment-Test: 05705-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 12:50:12  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 3| 2| 4| 3| 3| 3| 2| 2| 3|                                            |            |
                                           | 0| 1| 9| 5| 1| 1| 0| 9| 9| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |      A     |
    100MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
     FEMALE                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +                                             |  51        |
      Hyperplasia, Lymphoid                | 2                                                                        |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  53        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Parasite Metazoan                    |                                                                          |      3     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Ulcer, Acute                         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +                                             |  56        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +                                             |  54        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  54        |
      Amyloid Deposition                   |                                                                          |      1  3.0|
      Inflammation, Acute                  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  54        |
      Ulcer, Acute                         |          3                                                               |      1  3.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Basophilic Focus                     |                                                                          |      1  4.0|
      Hematopoietic Cell Proliferation     |                                                                          |            |
          Granulocytic                     |          3                                                               |      5  2.8|
      Inflammation, Acute                  |                                                                          |      1  2.0|
      Inflammation, Chronic                |       2                                                                  |     14  1.9|
      Inflammation, Chronic Active         |                                                                          |      1  1.0|
      Bile Duct, Hyperplasia               |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                   +  +                                                   |  16        |
      Inflammation, Acute                  |                                                                          |      1  4.0|
      Inflammation, Chronic                |                                                                          |      8  2.3|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Atrophy                              |                                                                          |      4  2.8|
      Clear Cell Focus                     |                                                                          |      1     |
      Inflammation, Chronic                | 2              2                                                         |      5  2.0|
      Duct, Cyst                           |                                                                          |      2     |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inflammation, Chronic                |                      3                                                   |      3  2.7|
      Mucocele                             |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hyperkeratosis                       |                                                                          |      4  2.0|
      Hyperplasia, Diffuse, Squamous       |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  37                                                               
NTP Experiment-Test: 05705-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 12:50:12  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 3| 2| 4| 3| 3| 3| 2| 2| 3|                                            |            |
                                           | 0| 1| 9| 5| 1| 1| 0| 9| 9| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |      A     |
    100MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
     FEMALE                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia, Focal, Squamous         |    3  1     1     2                                                      |     12  2.0|
      Hyperplasia, Multifocal, Squamous    |                                                                          |      3  2.3|
      Inflammation, Acute                  |                                                                          |      1  1.0|
      Inflammation, Acute, Multifocal      |                                                                          |      1  2.0|
      Inflammation, Chronic                |                            1                                             |      3  1.7|
      Ulcer                                |                                                                          |      2  2.0|
      Ulcer, Multifocal                    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Erosion                              |                                                                          |      2  1.5|
      Hyperplasia, Atypical, Focal         |                   3                                                      |      1  3.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   2        |
      Developmental Malformation           |                                                                          |      1     |
      Peridontal Tissue, Cyst              |                                                                          |      1     |
      Peridontal Tissue, Inflammation,     |                                                                          |            |
           Acute                           |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Degeneration                         |                                                                          |      5  1.6|
      Mineralization                       |                                                                          |      3  1.7|
      Coronary Artery, Inflammation,       |                                                                          |            |
          Chronic                          |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Angiectasis                          |                                                                          |      1  1.0|
      Fibrosis, Focal                      |                                                                          |      1  1.0|
      Hematopoietic Cell Proliferation     |                                                                          |            |
          Granulocytic                     |          X                                                               |      4  3.0|
      Hemorrhage                           |                                                                          |      1  2.0|
      Hyperplasia                          |                                                                          |      1  2.0|
      Hypertrophy                          |       1                                                                  |      4  2.0|
      Necrosis                             |                                                                          |      2  2.5|
      Subcapsular, Hyperplasia             | 2  3  3  3  3  3  3  3  3  4                                             |     58  2.9|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  M  +  +  +  +  M  +  M                                             |  43        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  38                                                               
NTP Experiment-Test: 05705-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 12:50:12  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 3| 2| 4| 3| 3| 3| 2| 2| 3|                                            |            |
                                           | 0| 1| 9| 5| 1| 1| 0| 9| 9| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |      A     |
    100MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
     FEMALE                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Cyst                                 |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  M  +  +  +  +  +                                             |  57        |
      Cyst                                 |                                                                          |      3     |
      Hyperplasia, Focal                   |    2                                                                     |      9  2.7|
      Hypertrophy, Focal                   |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inflammation, Chronic                |                                                                          |      2  1.0|
      Follicle, Cyst                       |                                                                          |      2     |
      Follicular Cell, Hyperplasia         |       3                                                                  |      5  2.4|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |                                                                          |   2        |
      Cyst                                 |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Ovary                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Abscess                              |                                                                          |      3  4.0|
      Cyst                                 | X     X           X                                                      |     25     |
      Cyst, Multiple                       |                X     X                                                   |     10     |
      Inflammation, Acute                  |                                                                          |      1  3.0|
      Mineralization                       |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Uterus                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Abscess                              |                                                                          |      2  4.0|
      Inflammation, Acute                  |                                                                          |      2  1.5|
      Thrombosis                           |                                                                          |      1  2.0|
      Endometrium, Hyperplasia, Cystic     | 3  2  3  2  3  2  2  2  3  2                                             |     45  2.5|
                                            __________________________________________________________________________|____________|
   Vagina                                  |             +                                                            |   3        |
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Myelofibrosis                        | 1  2  1     1        2                                                   |     22  1.7|
      Myeloid Cell, Hyperplasia            |          4                                                               |      4  4.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Iliac, Fibrosis                      |                                                                          |      1  1.0|
      Iliac, Hematopoietic Cell            |                                                                          |            |
          Proliferation Granulocytic       |                                                                          |      1  3.0|
      Iliac, Inflammation, Acute           |                                                                          |      1  2.0|
      Iliac, Inflammation, Chronic Active  |                                                                          |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  39                                                               
NTP Experiment-Test: 05705-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 12:50:12  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 3| 2| 4| 3| 3| 3| 2| 2| 3|                                            |            |
                                           | 0| 1| 9| 5| 1| 1| 0| 9| 9| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |      A     |
    100MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
     FEMALE                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Iliac, Pigmentation                  |                                                                          |      1  3.0|
      Inguinal, Inflammation, Acute        |                                                                          |      1  2.0|
      Mandibular, Hyperplasia, Lymphoid    |                                                                          |      1  3.0|
      Mediastinal, Hyperplasia, Lymphoid   |                                                                          |      1  3.0|
      Pancreatic, Inflammation, Acute      |                                                                          |      1  4.0|
      Renal, Inflammation, Acute           |          4                                                               |      2  3.5|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Hematopoietic Cell Proliferation     |                                                                          |            |
          Granulocytic                     |                                                                          |      1  1.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  4.0|
      Inflammation, Granulomatous          |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hematopoietic Cell Proliferation     |                                                                          |            |
          Granulocytic                     |          4                                                               |      5  3.8|
      Hematopoietic Cell Proliferation     |                                                                          |            |
          Erythrocytic                     |                                                                          |      3  3.3|
      Hyperplasia, Lymphoid                | 2  4           3        3                                                |     17  2.8|
      Hyperplasia, Plasma Cell             |                                                                          |      1  4.0|
      Inflammation, Granulomatous          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +  +  +  +  +  +                                             |  53        |
      Atrophy                              |          3                                                               |      2  3.0|
      Cyst                                 |    X                    X                                                |      9     |
      Necrosis                             |                                                                          |      2  2.0|
      Pigmentation, Lipofuscin             |          2                                                               |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Fibrosis, Focal                      |                                                                          |      1  2.0|
      Hemorrhage                           |                                                                          |      1  3.0|
      Duct, Cyst                           |                            X                                             |      4     |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Acanthosis                           |                                                                          |      1  2.0|
      Fibrosis                             |                                                                          |      1  3.0|
      Hyperkeratosis                       |                                                                          |      1  2.0|
      Inflammation, Acute, Chronic         |                                                                          |      1  1.0|
      Inflammation, Chronic                |                                                                          |      2  1.0|
      Parasite External                    |    X                    X                                                |      3     |
      Ulcer, Acute                         |          2                                                               |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  40                                                               
NTP Experiment-Test: 05705-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 12:50:12  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 3| 2| 4| 3| 3| 3| 2| 2| 3|                                            |            |
                                           | 0| 1| 9| 5| 1| 1| 0| 9| 9| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |      A     |
    100MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
     FEMALE                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 MUSCULOSKELETAL SYSTEM - cont             |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   2        |
      Edema                                |                                                                          |      1  3.0|
      Fibrosis                             |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Hemorrhage                           |                                                                          |      1  1.0|
      Mineralization                       |          2  2  2           2                                             |     24  1.8|
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Congestion                           |                                                                          |      2  3.0|
      Hemorrhage                           |                                                                          |      2  2.0|
      Inflammation, Acute, Focal           |                                                                          |      2  1.5|
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Alveolus, Crystals                   |                                                                          |      1  1.0|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |                                                                          |      2  2.0|
      Artery, Media, Hypertrophy           |                                                                          |      9  1.4|
      Bronchus, Fibrosis                   |                                                                          |      1  2.0|
      Interstitium, Fibrosis, Multifocal   |                                                                          |      1  2.0|
      Interstitium, Inflammation, Chronic, |                                                                          |            |
           Focal                           |                                                                          |      1  1.0|
      Perivascular, Infiltration Cellular, |                                                                          |            |
           Lymphocyte                      |       1        1     1     2                                             |     22  1.6|
      Pleura, Inflammation, Acute, Focal   |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cyst                                 |                                                                          |      1     |
      Exudate                              |                                                                          |     11  1.5|
      Granuloma                            |                                                                          |      1  2.0|
      Inflammation, Acute                  |    1     2        2  2  2                                                |     31  1.5|
      Inflammation, Chronic Active         |       2                                                                  |      5  1.8|
      Mucosa, Nasolacrimal Duct,           |                                                                          |            |
          Hyperplasia                      |    1  3  2  1  2  2  2  1  1                                             |     39  1.5|
      Nasolacrimal Duct, Hyperplasia       |                                                                          |      1  2.0|
      Olfactory Epithelium, Metaplasia     |    1  2           2                                                      |     17  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  41                                                               
NTP Experiment-Test: 05705-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 12:50:12  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 6| 7| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 3| 3| 2| 4| 3| 3| 3| 2| 2| 3|                                            |            |
                                           | 0| 1| 9| 5| 1| 1| 0| 9| 9| 1|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE FEMALE                      | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |      A     |
    100MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
     FEMALE                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inflammation, Acute                  |                                                                          |      3  2.0|
      Metaplasia, Squamous                 |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   1        |
      Cornea, Inflammation, Chronic        |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inflammation, Chronic                | 2  2     2     2        1                                                |     21  1.9|
      Mineralization                       |                                                                          |      1  1.0|
      Nephropathy                          |             1              1                                             |     12  1.3|
      Renal Tubule, Epithelium,            |                                                                          |            |
          Pigmentation                     |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  M  +  +  +  +  +  +                                             |  56        |
      Inflammation, Chronic                | 2                    3                                                   |      3  2.3|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  42                                                               
NTP Experiment-Test: 05705-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 12:50:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 5| 7| 7| 0| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 3| 2| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 2| 2| 6| 3| 3| 5| 3| 3| 3| 0|             
                                           | 9| 0| 9| 1| 1| 1| 9| 1| 0| 0| 5| 1| 0| 1| 0| 9| 9| 6| 0| 0| 9| 0| 0| 1| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  M  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                           X        X                     |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus, Multiple           |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |                                  2        1                              |             
      Inflammation, Chronic Active,        |                                                                          |             
          Multifocal                       |                                                                      2   |             
      Necrosis                             |                                                                          |             
      Bile Duct, Cyst                      |    X                                                                     |             
      Hepatocyte, Necrosis                 |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |          +                                            +                  |             
      Inflammation, Chronic                |          1                                            1                  |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                  1              1                        |             
      Hyperplasia, Focal                   |                                                                          |             
      Inflammation, Chronic                |       1                                                                  |             
      Necrosis, Multifocal                 |                                                                          |             
      Duct, Cyst                           |                                        1                                 |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Diverticulum                         |                         1                                                |             
      Erosion                              |                                                                          |             
      Hyperkeratosis                       |                                                                          |             
      Hyperplasia, Focal, Squamous         |                                                          3               |             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                             1            |             
      Inflammation, Acute                  |                                                                          |             
      Epithelium, Hyperplasia, Focal       |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                         +  +                                             |             
      Peridontal Tissue, Inflammation,     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  43                                                               
NTP Experiment-Test: 05705-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 12:50:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 5| 7| 7| 0| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 3| 2| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 2| 2| 6| 3| 3| 5| 3| 3| 3| 0|             
                                           | 9| 0| 9| 1| 1| 1| 9| 1| 0| 0| 5| 1| 0| 1| 0| 9| 9| 6| 0| 0| 9| 0| 0| 1| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
           Acute                           |                            2                                             |             
      Pulp, Inflammation, Acute            |                         1                                                |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +     +|             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration                         | 1        3     2     1              1  1  1           1                  |             
      Inflammation, Acute, Multifocal      |                                                                          |             
      Mineralization                       |                1                                                         |             
      Epicardium, Inflammation, Chronic    |                                                                          |             
      Valve, Pigmentation                  |                         1        1                    2        1         |             
      Ventricle, Thrombosis                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Cytoplasmic Alteration, Focal        |                                                                          |             
      Hyperplasia, Focal                   |                                                                          |             
      Hyperplasia                          |                                                          3               |             
      Hypertrophy, Focal                   |                                                                          |             
      Subcapsular, Hyperplasia             | 1  4  2  1  2  2  1  3  3  1     2  2  2  4  1  2  2  2  2     2  2  3  3|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  +  M  M  +  +  +  M  +  +  +  +  M  M  +  I  +  +  M  +  M  M  M|             
      Cyst                                 |          X                                                               |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | M  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hyperplasia, Focal                   |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                        1  1                              |             
      Mineralization                       |                                                                          |             
      Follicle, Cyst                       |                                                                      X   |             
      Follicular Cell, Hyperplasia         |                      2                                                   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                | 1                                                                        |             
                                            __________________________________________________________________________|             
   Penis                                   |                   +                             +     +                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  44                                                               
NTP Experiment-Test: 05705-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 12:50:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 5| 7| 7| 0| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 3| 2| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 2| 2| 6| 3| 3| 5| 3| 3| 3| 0|             
                                           | 9| 0| 9| 1| 1| 1| 9| 1| 0| 0| 5| 1| 0| 1| 0| 9| 9| 6| 0| 0| 9| 0| 0| 1| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                                                 +  +                     |             
      Abscess                              |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |                                                 1                        |             
      Inflammation, Granulomatous          |                                                    4                     |             
      Duct, Cyst                           |                                                 3  X                     |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |                                                       4                  |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |                               +                             +            |             
      Dilatation                           |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration                         |                                        1                                 |             
      Mineralization                       |                                                 1                        |             
      Unilateral, Atrophy                  |                                  3                                       |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Myeloid Cell, Hyperplasia            |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inguinal, Hyperplasia, Lymphoid      |                                                    4                     |             
      Inguinal, Hyperplasia, Plasma Cell   |                                                                          |             
      Inguinal, Inflammation, Acute        |                                                                          |             
      Inguinal, Pigmentation               |                                                                          |             
      Mediastinal, Hemorrhage              |                                                                          |             
      Pancreatic, Hyperplasia, Lymphoid    |                                                 2                        |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                                          |             
          Granulocytic                     |                                                                          |             
      Hyperplasia, Lymphoid                |                            3                                             |             
      Inflammation, Acute                  |                                                                      2   |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                                          |             
          Granulocytic                     |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
          Erythrocytic                     |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Hyperplasia, Plasma Cell             |                                                                          |             
      Infarct                              |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | M  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                    4        3           3|             
      Cyst                                 |                                  X           X                 X         |             
      Ectopic Parathyroid Gland            |                                                                          |             
      Epithelial Cell, Hyperplasia         |    2           2        1  2              2     1     2                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  45                                                               
NTP Experiment-Test: 05705-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 12:50:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 5| 7| 7| 0| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 3| 2| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 2| 2| 6| 3| 3| 5| 3| 3| 3| 0|             
                                           | 9| 0| 9| 1| 1| 1| 9| 1| 0| 0| 5| 1| 0| 1| 0| 9| 9| 6| 0| 0| 9| 0| 0| 1| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  +  M  M  M  M  M  M  M  +  M  M  M  M  I  +  M  +  M  M  M  M  M  +|             
      Hemorrhage, Focal                    |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                                                                          |             
      Acanthosis                           |                                                                          |             
      Fibrosis                             |                                                                          |             
      Hyperkeratosis                       |                                                                          |             
      Hyperplasia, Basal Cell, Focal       |                                                                          |             
      Parasite External                    |                               X                                          |             
      Ulcer                                |                                           3                              |             
      Prepuce, Inflammation, Acute         |                                                                          |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic                         |    2                                                                     |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fracture Healed                      |                                                 X                        |             
      Osteoporosis, Focal                  |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute, Multifocal      |                                                                          |             
      Mineralization                       | 2  2        1     1  2  1  1  2  1  1  2  3  1  3  2  1  2     3     2   |             
      Necrosis, Focal                      |                                                                          |             
      Meninges, Perivascular, Inflammation,|                                                                          |             
           Chronic                         |          3                                                               |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                             +            |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                                                   2      |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                                                                          |             
      Perivascular, Infiltration Cellular, |                                                                          |             
           Lymphocyte                      | 1                                                                        |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Exudate                              |                         1                 2     1           1        1  1|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  46                                                               
NTP Experiment-Test: 05705-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 12:50:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 7| 7| 7| 7| 7| 6| 7| 7| 7| 4| 7| 7| 7| 7| 7| 7| 5| 7| 7| 0| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 3| 2| 3| 3| 3| 3| 3| 3| 3| 5| 3| 3| 3| 3| 2| 2| 6| 3| 3| 5| 3| 3| 3| 0|             
                                           | 9| 0| 9| 1| 1| 1| 9| 1| 0| 0| 5| 1| 0| 1| 0| 9| 9| 6| 0| 0| 9| 0| 0| 1| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Granuloma                            |                                                                          |             
      Inflammation, Acute                  | 1                                                     1                  |             
      Inflammation, Chronic                |                                                                          |             
      Mucosa, Nasolacrimal Duct,           |                                                                          |             
          Hyperplasia                      |    2     2           1  3              1  2     2     4  1        2      |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Acute                           |    2                                                                     |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Chronic Active                  |                                                                   2      |             
      Submucosa, Cyst                      |                                              X                           |             
      Turbinate, Inflammation, Chronic,    |                                                                          |             
           Multifocal                      |                                           1                              |             
      Vomeronasal Organ, Cyst              |                                              X                           |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |    +                                                              +      |             
      Cyst, Multiple                       |    X                                                                     |             
      Inflammation, Chronic                |    2                                                                     |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                      X                                                   |             
      Inflammation, Acute                  |                                                                          |             
      Mineralization                       |                                                                          |             
      Nephropathy                          | 1  1  1     1  2     1  1  1     2  1     2     2     1        2  2  1   |             
      Pelvis, Inflammation, Chronic        |          3                                            3                  |             
      Renal Tubule, Hyperplasia, Focal     |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +|             
      Calculus Gross Observation           |                                                       X                  |             
      Diverticulum                         |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |                                                       4                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  47                                                               
NTP Experiment-Test: 05705-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 12:50:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 3| 6| 7| 7| 7| 5| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 5| 2| 3| 3| 2| 6| 2| 3| 3| 3| 1| 3| 2| 2| 8| 2| 5| 2| 2| 3| 2| 3| 3| 3| 3|             
                                           | 2| 9| 0| 1| 9| 1| 7| 1| 1| 0| 7| 0| 9| 9| 9| 9| 7| 9| 9| 1| 9| 1| 7| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    CONTROL                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  A  A  +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  A  A  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                               X        X                                 |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  A  A  +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  A  A  +  +  +  A  +  +  +  A  +  A  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  A  A  +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  A  A  +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  A  +  +|             
      Hyperplasia, Lymphoid                |                            2                                             |             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus, Multiple           |                      4                                                   |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active,        |                                                                          |             
          Multifocal                       |                                                                          |             
      Necrosis                             |                               1                                         1|             
      Bile Duct, Cyst                      |                                                                          |             
      Hepatocyte, Necrosis                 |                   2                                                      |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                 +                 +      |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Atrophy                              |                            2                                             |             
      Hyperplasia, Focal                   |                                                       2                  |             
      Inflammation, Chronic                |                                                                          |             
      Necrosis, Multifocal                 |                                                       1                  |             
      Duct, Cyst                           |                                                                          |             
                                            __________________________________________________________________________|             
   Pharynx                                 |                                     +                                    |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Diverticulum                         |          1                                                               |             
      Erosion                              |    1                                                                     |             
      Hyperkeratosis                       |                                                                          |             
      Hyperplasia, Focal, Squamous         |                                     1                                    |             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Erosion                              |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Epithelium, Hyperplasia, Focal       |                                                                3         |             
                                            __________________________________________________________________________|             
   Tooth                                   |    +                    +           +                                    |             
      Peridontal Tissue, Inflammation,     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  48                                                               
NTP Experiment-Test: 05705-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 12:50:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 3| 6| 7| 7| 7| 5| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 5| 2| 3| 3| 2| 6| 2| 3| 3| 3| 1| 3| 2| 2| 8| 2| 5| 2| 2| 3| 2| 3| 3| 3| 3|             
                                           | 2| 9| 0| 1| 9| 1| 7| 1| 1| 0| 7| 0| 9| 9| 9| 9| 7| 9| 9| 1| 9| 1| 7| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    CONTROL                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
           Acute                           |                                                                          |             
      Pulp, Inflammation, Acute            |    2                    4                                                |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration                         |    1  1  1           1  1        1  1  1  1     1              1         |             
      Inflammation, Acute, Multifocal      |                                                                          |             
      Mineralization                       |                                                                          |             
      Epicardium, Inflammation, Chronic    |                                           2                              |             
      Valve, Pigmentation                  |          3                          1                          1         |             
      Ventricle, Thrombosis                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                   X                                                      |             
      Cytoplasmic Alteration, Focal        |    2                                                                     |             
      Hyperplasia, Focal                   |                         2                                                |             
      Hyperplasia                          |                            2                                             |             
      Hypertrophy, Focal                   |             3                                                            |             
      Subcapsular, Hyperplasia             | 1     3  1  3     2  1  1  4  1  1  1  2  3  2  1     2  1  2  2  2  2  1|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                2         |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | +  +  +  M  +  +  M  +  M  M  M  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +|             
      Cyst                                 |                         X                                                |             
      Hyperplasia, Focal                   |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Mineralization                       |          1                                                               |             
      Follicle, Cyst                       |             X                    X           X                           |             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Penis                                   |          +                                            +        +        +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  49                                                               
NTP Experiment-Test: 05705-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 12:50:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 3| 6| 7| 7| 7| 5| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 5| 2| 3| 3| 2| 6| 2| 3| 3| 3| 1| 3| 2| 2| 8| 2| 5| 2| 2| 3| 2| 3| 3| 3| 3|             
                                           | 2| 9| 0| 1| 9| 1| 7| 1| 1| 0| 7| 0| 9| 9| 9| 9| 7| 9| 9| 1| 9| 1| 7| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    CONTROL                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                                           +     +                        |             
      Abscess                              |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Granulomatous          |                                                 3                        |             
      Duct, Cyst                           |                                           X                              |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |                               +                                         +|             
      Dilatation                           |                                                                         4|             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration                         |                                  3                 3                     |             
      Mineralization                       |          1                                                               |             
      Unilateral, Atrophy                  |                         2                                                |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Myeloid Cell, Hyperplasia            |                                                 4                        |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inguinal, Hyperplasia, Lymphoid      |                                                                3         |             
      Inguinal, Hyperplasia, Plasma Cell   |                   3                                                     4|             
      Inguinal, Inflammation, Acute        |                                                                          |             
      Inguinal, Pigmentation               |                2        2                                                |             
      Mediastinal, Hemorrhage              | 3                                                                        |             
      Pancreatic, Hyperplasia, Lymphoid    |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  A  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                                          |             
          Granulocytic                     |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hematopoietic Cell Proliferation     |                                                                          |             
          Granulocytic                     |                                                 3                        |             
      Hematopoietic Cell Proliferation     |                                                                          |             
          Erythrocytic                     |                         4                                                |             
      Hyperplasia, Lymphoid                |                                  2                                       |             
      Hyperplasia, Plasma Cell             |                                                                          |             
      Infarct                              |                            4                                             |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  M  +  I  +  +  M  +  +  +  +  I  +  M  +  +  +  +  +  M  +  +|             
      Atrophy                              |                               3                                          |             
      Cyst                                 |                                                                      X   |             
      Ectopic Parathyroid Gland            |                                     X                                    |             
      Epithelial Cell, Hyperplasia         |                                                                4         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  50                                                               
NTP Experiment-Test: 05705-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 12:50:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 3| 6| 7| 7| 7| 5| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 5| 2| 3| 3| 2| 6| 2| 3| 3| 3| 1| 3| 2| 2| 8| 2| 5| 2| 2| 3| 2| 3| 3| 3| 3|             
                                           | 2| 9| 0| 1| 9| 1| 7| 1| 1| 0| 7| 0| 9| 9| 9| 9| 7| 9| 9| 1| 9| 1| 7| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    CONTROL                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  M  M  M  M  M  M  +  M  M  M  +  M  M  +  M  M  M  M  +  M  +  M  M  M|             
      Hemorrhage, Focal                    |                                           2                              |             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess                              |                   3                                                      |             
      Acanthosis                           |                                                                          |             
      Fibrosis                             |                                                                          |             
      Hyperkeratosis                       |                                                                          |             
      Hyperplasia, Basal Cell, Focal       |          2                                                               |             
      Parasite External                    |                                                                          |             
      Ulcer                                |                                                                          |             
      Prepuce, Inflammation, Acute         |                                                                          |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Chronic                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fracture Healed                      |                                                                          |             
      Osteoporosis, Focal                  |                                        2                                 |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                           +                              |             
      Inflammation, Chronic                |                                           4                              |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute, Multifocal      |                                                                          |             
      Mineralization                       |    2  2  2  2     2  1     1  2  4  2  2     1  1           2  2  2  3  2|             
      Necrosis, Focal                      |                                                                          |             
      Meninges, Perivascular, Inflammation,|                                                                          |             
           Chronic                         |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                3                                                         |             
      Hemorrhage                           |                                           3                              |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                                                          |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                                     2              2                     |             
      Perivascular, Infiltration Cellular, |                                                                          |             
           Lymphocyte                      |             1                                      2                     |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Exudate                              |                         1           1     1  1                    1  1   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  51                                                               
NTP Experiment-Test: 05705-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 12:50:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 6| 7| 7| 7| 7| 3| 6| 7| 7| 7| 5| 7| 7| 7| 6| 7| 6| 7| 7| 7| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 5| 2| 3| 3| 2| 6| 2| 3| 3| 3| 1| 3| 2| 2| 8| 2| 5| 2| 2| 3| 2| 3| 3| 3| 3|             
                                           | 2| 9| 0| 1| 9| 1| 7| 1| 1| 0| 7| 0| 9| 9| 9| 9| 7| 9| 9| 1| 9| 1| 7| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    CONTROL                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Granuloma                            |          1                                                               |             
      Inflammation, Acute                  |                   1                                                      |             
      Inflammation, Chronic                |                                                             2            |             
      Mucosa, Nasolacrimal Duct,           |                                                                          |             
          Hyperplasia                      | 3        1  1        2              1                 2              1  1|             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Acute                           |                                                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Chronic Active                  |                                                                          |             
      Submucosa, Cyst                      |                                                                          |             
      Turbinate, Inflammation, Chronic,    |                                                                          |             
           Multifocal                      |                                                                          |             
      Vomeronasal Organ, Cyst              |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
      Cyst, Multiple                       |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                    X                     |             
      Inflammation, Acute                  |                                                                          |             
      Mineralization                       |                                                    1                     |             
      Nephropathy                          |    2  3  1  1        1     1     2     1     1     1  1        1        1|             
      Pelvis, Inflammation, Chronic        |                                                                          |             
      Renal Tubule, Hyperplasia, Focal     |                         3                                                |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +|             
      Calculus Gross Observation           |                                                                          |             
      Diverticulum                         |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  52                                                               
NTP Experiment-Test: 05705-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 12:50:12  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 5| 3| 2| 1| 3| 3| 2| 2| 3| 2|                                            |            |
                                           | 7| 0| 9| 6| 0| 0| 9| 9| 1| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  A  +  +  +  +  +  +                                             |  51        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | A  +  +  +  +  +  +  +  +  +                                             |  55        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Parasite Metazoan                    |                   X                                                      |      5     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +                                             |  58        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | A  +  +  +  +  +  +  +  +  +                                             |  54        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | A  +  +  A  +  +  +  +  +  +                                             |  51        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | A  +  +  +  +  +  +  +  +  +                                             |  54        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | A  +  +  +  +  +  +  +  +  +                                             |  53        |
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Basophilic Focus, Multiple           |                                                                          |      1  4.0|
      Inflammation, Acute                  |       1                                                                  |      1  1.0|
      Inflammation, Chronic                |                      1                                                   |      3  1.3|
      Inflammation, Chronic Active,        |                                                                          |            |
          Multifocal                       |                                                                          |      1  2.0|
      Necrosis                             |                                                                          |      2  1.0|
      Bile Duct, Cyst                      |                                                                          |      1     |
      Hepatocyte, Necrosis                 |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   4        |
      Inflammation, Chronic                |                                                                          |      2  1.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Atrophy                              |                                                                          |      3  1.3|
      Hyperplasia, Focal                   |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                                                          |      1  1.0|
      Necrosis, Multifocal                 |                                                                          |      1  1.0|
      Duct, Cyst                           |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Pharynx                                 |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Diverticulum                         |    1                                                                     |      3  1.0|
      Erosion                              |                                                                          |      1  1.0|
      Hyperkeratosis                       |       2                                                                  |      1  2.0|
      Hyperplasia, Focal, Squamous         |       2              4  3                                                |      5  2.6|
      Inflammation, Acute                  |       1                                                                  |      1  1.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | I  +  +  +  +  +  +  +  +  +                                             |  58        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  53                                                               
NTP Experiment-Test: 05705-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 12:50:12  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 5| 3| 2| 1| 3| 3| 2| 2| 3| 2|                                            |            |
                                           | 7| 0| 9| 6| 0| 0| 9| 9| 1| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Erosion                              |                                                                          |      1  1.0|
      Inflammation, Acute                  |       3                                                                  |      1  3.0|
      Epithelium, Hyperplasia, Focal       |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   5        |
      Peridontal Tissue, Inflammation,     |                                                                          |            |
           Acute                           |                                                                          |      1  2.0|
      Pulp, Inflammation, Acute            |                                                                          |      3  2.3|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +                                             |  58        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Degeneration                         |                      3  2                                                |     21  1.3|
      Inflammation, Acute, Multifocal      |          3                                                               |      1  3.0|
      Mineralization                       |                                                                          |      1  1.0|
      Epicardium, Inflammation, Chronic    |                                                                          |      1  2.0|
      Valve, Pigmentation                  |    2                                                                     |      8  1.5|
      Ventricle, Thrombosis                |          X                                                               |      1     |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cyst                                 |                                                                          |      1     |
      Cytoplasmic Alteration, Focal        |                                                                          |      1  2.0|
      Hyperplasia, Focal                   |                                                                          |      1  2.0|
      Hyperplasia                          |             4     1                                                      |      4  2.5|
      Hypertrophy, Focal                   |                                                                          |      1  3.0|
      Subcapsular, Hyperplasia             |    1  3  2  1  3  2  4  2  2                                             |     54  2.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Hyperplasia                          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  M  +  +  +  +                                             |  56        |
      Hyperplasia                          |    2                                                                     |      1  2.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | M  +  +  +  +  M  M  +  +  +                                             |  41        |
      Cyst                                 |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  56        |
      Cyst                                 |             X                                                            |      2     |
      Hyperplasia, Focal                   |       2                                                                  |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inflammation, Chronic                |                                                                          |      2  1.0|
      Mineralization                       |                                                                          |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  54                                                               
NTP Experiment-Test: 05705-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 12:50:12  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 5| 3| 2| 1| 3| 3| 2| 2| 3| 2|                                            |            |
                                           | 7| 0| 9| 6| 0| 0| 9| 9| 1| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Follicle, Cyst                       |          X                 X                                             |      6     |
      Follicular Cell, Hyperplasia         |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inflammation, Chronic                |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Penis                                   |                   +  +                                                   |   9        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +        +           +  +                                                |   8        |
      Abscess                              |                      4  4                                                |      2  4.0|
      Inflammation, Acute                  | 2                                                                        |      1  2.0|
      Inflammation, Chronic                |                                                                          |      1  1.0|
      Inflammation, Granulomatous          |          2                                                               |      3  3.0|
      Duct, Cyst                           | X        X                                                               |      5  3.0|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Inflammation, Acute                  | 3                                                                        |      1  3.0|
      Inflammation, Chronic                |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |          +                                                               |   5        |
      Dilatation                           |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Degeneration                         |                                                                          |      3  2.3|
      Mineralization                       |                                                                          |      2  1.0|
      Unilateral, Atrophy                  |                                                                          |      2  2.5|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Myeloid Cell, Hyperplasia            | 4        3                                                               |      3  3.7|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Inguinal, Hyperplasia, Lymphoid      |                                                                          |      2  3.5|
      Inguinal, Hyperplasia, Plasma Cell   |                      4  3                                                |      4  3.5|
      Inguinal, Inflammation, Acute        | 2                                                                        |      1  2.0|
      Inguinal, Pigmentation               |                                                                          |      2  2.0|
      Mediastinal, Hemorrhage              |                                                                          |      1  3.0|
      Pancreatic, Hyperplasia, Lymphoid    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | I  +  +  +  +  +  +  +  +  +                                             |  56        |
      Hematopoietic Cell Proliferation     |                                                                          |            |
          Granulocytic                     |                         3                                                |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  55                                                               
NTP Experiment-Test: 05705-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 12:50:12  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 5| 3| 2| 1| 3| 3| 2| 2| 3| 2|                                            |            |
                                           | 7| 0| 9| 6| 0| 0| 9| 9| 1| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
      Inflammation, Acute                  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Hematopoietic Cell Proliferation     |                                                                          |            |
          Granulocytic                     | 4        3              2                                                |      4  3.0|
      Hematopoietic Cell Proliferation     |                                                                          |            |
          Erythrocytic                     |                                                                          |      1  4.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
      Hyperplasia, Plasma Cell             |          3                                                               |      1  3.0|
      Infarct                              |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | M  +  +  M  +  +  +  +  M  +                                             |  49        |
      Atrophy                              |                                                                          |      4  3.3|
      Cyst                                 |                                                                          |      4     |
      Ectopic Parathyroid Gland            |                                                                          |      1     |
      Epithelial Cell, Hyperplasia         |                   3                                                      |      9  2.1|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  +  M  M  M  M  +  M                                             |  13        |
      Hemorrhage, Focal                    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Abscess                              |                                                                          |      1  3.0|
      Acanthosis                           |                         2                                                |      1  2.0|
      Fibrosis                             |                         2                                                |      1  2.0|
      Hyperkeratosis                       |          2                                                               |      1  2.0|
      Hyperplasia, Basal Cell, Focal       |                                                                          |      1  2.0|
      Parasite External                    |                         X                                                |      2     |
      Ulcer                                |                                                                          |      1  3.0|
      Prepuce, Inflammation, Acute         | 4                                                                        |      1  4.0|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
           Chronic                         |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Fracture Healed                      |                                                                          |      1     |
      Osteoporosis, Focal                  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
      Inflammation, Chronic                |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  56                                                               
NTP Experiment-Test: 05705-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 12:50:12  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 5| 3| 2| 1| 3| 3| 2| 2| 3| 2|                                            |            |
                                           | 7| 0| 9| 6| 0| 0| 9| 9| 1| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inflammation, Acute, Multifocal      |          2                                                               |      1  2.0|
      Mineralization                       |    2  2  1  2  1  1  2     2                                             |     45  1.8|
      Necrosis, Focal                      |          2                                                               |      1  2.0|
      Meninges, Perivascular, Inflammation,|                                                                          |            |
           Chronic                         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Congestion                           |                                                                          |      1  3.0|
      Hemorrhage                           |                                                                          |      1  3.0|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |                                                                          |      1  2.0|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |                                                                          |      2  2.0|
      Perivascular, Infiltration Cellular, |                                                                          |            |
           Lymphocyte                      |          1        1                                                      |      5  1.2|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Exudate                              |    1                 1  1                                                |     15  1.1|
      Granuloma                            |                2                                                         |      2  1.5|
      Inflammation, Acute                  |                                                                          |      3  1.0|
      Inflammation, Chronic                |                            1                                             |      2  1.5|
      Mucosa, Nasolacrimal Duct,           |                                                                          |            |
          Hyperplasia                      |    3  2     2        1  1                                                |     23  1.8|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Acute                           |                                                                          |      1  2.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Chronic Active                  |                                                                          |      1  2.0|
      Submucosa, Cyst                      |                                                                          |      1     |
      Turbinate, Inflammation, Chronic,    |                                                                          |            |
           Multifocal                      |                                                                          |      1  1.0|
      Vomeronasal Organ, Cyst              |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                      +                                                   |   3        |
      Cyst, Multiple                       |                                                                          |      1     |
      Inflammation, Chronic                |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  57                                                               
NTP Experiment-Test: 05705-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 12:50:12  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 7| 7| 7| 7| 7| 7| 7| 7| 7|                                            |            |
                             DAY ON TEST   | 5| 3| 2| 1| 3| 3| 2| 2| 3| 2|                                            |            |
                                           | 7| 0| 9| 6| 0| 0| 9| 9| 1| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|                                            |      A     |
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|                                            |      L     |
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cyst                                 |                   X                                                      |      3     |
      Inflammation, Acute                  |          3                                                               |      1  3.0|
      Mineralization                       |                   1                                                      |      2  1.0|
      Nephropathy                          |    1  1     1  1  2  1  1                                                |     36  1.3|
      Pelvis, Inflammation, Chronic        |                                                                          |      2  3.0|
      Renal Tubule, Hyperplasia, Focal     |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  57        |
      Calculus Gross Observation           |                                                                          |      1     |
      Diverticulum                         |                            1                                             |      1  1.0|
      Inflammation, Acute                  | 3                                                                        |      1  3.0|
      Inflammation, Chronic                |                                                                          |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  58                                                               
NTP Experiment-Test: 05705-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 12:50:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 0| 1| 7| 7| 7| 7| 6| 7| 7| 7| 0| 7| 5| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5|             
                             DAY ON TEST   | 0| 2| 3| 3| 3| 3| 5| 2| 2| 3| 6| 3| 6| 3| 7| 3| 2| 3| 1| 1| 3| 3| 2| 2| 8|             
                                           | 6| 6| 0| 0| 0| 1| 9| 9| 9| 1| 6| 0| 6| 1| 0| 0| 9| 1| 4| 6| 0| 1| 9| 9| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    50 MG/KG                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
     MALE                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer, Acute                         |                                                                          |             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  A  +  +  +  +  +  A|             
      Cyst                                 |          X                                                               |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Plasma Cell   |                                                                          |             
      Parasite Metazoan                    |                                                       X  X              X|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
      Amyloid Deposition                   |                                                                          |             
      Parasite Metazoan                    |                                                          X               |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Cytoplasmic Alteration               |                                                                          |             
      Infarct                              |                                                                          |             
      Inflammation, Chronic                |       1                                                                  |             
      Necrosis                             |                   3                                   1  1               |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Artery, Perivascular, Inflammation,  |                                                                          |             
           Chronic                         |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |             1                                                            |             
      Cyst                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hyperplasia, Focal, Squamous         |                            2                                             |             
      Ulcer                                |             2                                                            |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Erosion                              |                               1                                          |             
      Inflammation, Acute                  |                                                          1               |             
      Inflammation, Chronic                |                                                                      1   |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Developmental Malformation           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  59                                                               
NTP Experiment-Test: 05705-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 12:50:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 0| 1| 7| 7| 7| 7| 6| 7| 7| 7| 0| 7| 5| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5|             
                             DAY ON TEST   | 0| 2| 3| 3| 3| 3| 5| 2| 2| 3| 6| 3| 6| 3| 7| 3| 2| 3| 1| 1| 3| 3| 2| 2| 8|             
                                           | 6| 6| 0| 0| 0| 1| 9| 9| 9| 1| 6| 0| 6| 1| 0| 0| 9| 1| 4| 6| 0| 1| 9| 9| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    50 MG/KG                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
     MALE                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Peridontal Tissue, Inflammation,     |                                                                          |             
           Acute                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration                         |                   1  1              1           1        2               |             
      Inflammation, Chronic                |          1                                                               |             
      Atrium, Pigmentation                 |                                                                          |             
      Atrium, Thrombosis                   |                                                          X               |             
      Epicardium, Fibrosis                 |                                                                          |             
      Valve, Pigmentation                  |                                  1                 1                 2   |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                           1                              |             
      Subcapsular, Hyperplasia             |       3  1     2  1  1  2  2     1  2  2  2  2  2  2  1  1  2  2  2  2  2|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  M  +  +  M  M  +  +  M  M  +  +  +  M  M  M  M  M  +  M  M  M  +  M|             
      Cyst                                 |                         X                                                |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  I  +  +|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicle, Cyst                       |                                                                   X      |             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       |                                                                          |             
      Cyst                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |          2                                                               |             
                                            __________________________________________________________________________|             
   Penis                                   |       +           +                 +           +                        |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |    +                                            +                        |             
      Hemorrhage                           |    2                                                                     |             
      Inflammation, Chronic                |                                                 3                        |             
      Duct, Cyst                           |                                                 X                        |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |                                                                         +|             
      Dilatation                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  60                                                               
NTP Experiment-Test: 05705-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 12:50:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 0| 1| 7| 7| 7| 7| 6| 7| 7| 7| 0| 7| 5| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5|             
                             DAY ON TEST   | 0| 2| 3| 3| 3| 3| 5| 2| 2| 3| 6| 3| 6| 3| 7| 3| 2| 3| 1| 1| 3| 3| 2| 2| 8|             
                                           | 6| 6| 0| 0| 0| 1| 9| 9| 9| 1| 6| 0| 6| 1| 0| 0| 9| 1| 4| 6| 0| 1| 9| 9| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    50 MG/KG                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
     MALE                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration                         |          2                          1                                   1|             
      Mineralization                       |          1                 1           1                    1  1  1      |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Myeloid Cell, Hyperplasia            |                                                       3                 1|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +|             
      Inguinal, Hyperplasia, Plasma Cell   |                                                 4        3               |             
      Inguinal, Pigmentation               |          3                                                               |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +|             
      Inflammation, Acute                  |                                                                         3|             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy, Focal                       |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
          Granulocytic                     |                                                       X                 X|             
      Hematopoietic Cell Proliferation     |                                                                          |             
          Erythrocytic                     |                                                          3               |             
      Hyperplasia, Lymphoid                |                                  2                                       |             
      Capsule, Fibrosis                    |                                                                2         |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  +  +  +  +  +  +  +  M  I  M  +  M  +  I  +  M  M  +  +  +  +  M|             
      Atrophy                              | 3                                                                        |             
      Cyst                                 |       X                                                                  |             
      Ectopic Parathyroid Gland            |          X                             X                                 |             
      Necrosis                             |                                                                          |             
      Epithelial Cell, Hyperplasia         |          2              1                                                |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +  M  M  +  M  +  M  M  M  M  M  M  M  M  M  M  M  +  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                         3                                                |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Parasite External                    |                      X                    X                              |             
      Prepuce, Abscess                     |    3                                                                     |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                       +                  |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                               1                                          |             
      Melanosis                            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  61                                                               
NTP Experiment-Test: 05705-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 12:50:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 0| 1| 7| 7| 7| 7| 6| 7| 7| 7| 0| 7| 5| 7| 6| 7| 7| 7| 6| 7| 7| 7| 7| 7| 5|             
                             DAY ON TEST   | 0| 2| 3| 3| 3| 3| 5| 2| 2| 3| 6| 3| 6| 3| 7| 3| 2| 3| 1| 1| 3| 3| 2| 2| 8|             
                                           | 6| 6| 0| 0| 0| 1| 9| 9| 9| 1| 6| 0| 6| 1| 0| 0| 9| 1| 4| 6| 0| 1| 9| 9| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    50 MG/KG                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
     MALE                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Mineralization                       |          2  2  1     2  2  2     2  1        2  3  2     2  2        2  2|             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                               +                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |    3                                                                     |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                  3                                2      |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |             1           2                                   1            |             
      Interstitium, Inflammation, Chronic  |          1                                                               |             
      Perivascular, Infiltration Cellular, |                                                                          |             
           Lymphocyte                      |             1           2        1           1              1            |             
      Pleura, Fibrosis                     |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Exudate                              |    1        1  1        1     3                 1                    1   |             
      Granuloma                            |                                                                          |             
      Inflammation, Acute                  | 1                                                                        |             
      Inflammation, Chronic                |                            1                                   2         |             
      Inflammation, Chronic Active         |                                                                          |             
      Mucosa, Nasolacrimal Duct,           |                                                                          |             
          Hyperplasia                      |       2  1     3                 1              1  1  1     1        1  2|             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Acute                           |                                                       2  1               |             
      Olfactory Epithelium, Metaplasia     |                1                                                         |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Metaplasia, Squamous                 |                                                                          |             
      Ulcer, Acute                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                  +        +                              |             
      Inflammation, Acute                  |                                  1                                       |             
      Neovascularization                   |                                           3                              |             
      Cornea, Necrosis                     |                                           1                              |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                  +        +                              |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                X                       X                 X               |             
      Mineralization                       |                                                    1                     |             
      Nephropathy                          |       1  1  2  1  1  1  1  1     2        1  1  1  1  1        1     1   |             
                                            __________________________________________________________________________|             
   Ureter                                  |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  62                                                               
NTP Experiment-Test: 05705-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 12:50:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 7| 7| 0| 0| 5| 7| 6| 1| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 7| 7| 2| 3| 1| 6| 4| 3| 8| 3| 3| 3| 3| 1| 0| 2| 3| 3| 2| 2| 3| 3| 3| 3|             
                                           | 9| 3| 4| 9| 0| 1| 6| 2| 0| 7| 6| 1| 1| 0| 4| 6| 9| 1| 0| 9| 9| 0| 1| 0| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    50 MG/KG                               | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
     MALE                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Ulcer, Acute                         |    4                                                                     |             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  +  +  +  +  +  A  A  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  M  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Plasma Cell   |       2                                                                  |             
      Parasite Metazoan                    |                            X                                             |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |       1                                                                  |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  +  +  A  +  +  +  A  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  +  A  A  +  +  +  A  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +  +  +  +  +  +  A  A  +  +  A  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Amyloid Deposition                   |                                  1                                       |             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +  +  +  +  +  +  A  +  +  +  A  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Cytoplasmic Alteration               |                                                                          |             
      Infarct                              |                            1                                             |             
      Inflammation, Chronic                |                                  1  1                                   1|             
      Necrosis                             |                            3                                             |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                        +                                 |             
      Artery, Perivascular, Inflammation,  |                                                                          |             
           Chronic                         |                                        3                                 |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Cyst                                 |                      X                                                   |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |    1                                2                                    |             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hyperplasia, Focal, Squamous         |                                        2                                 |             
      Ulcer                                |       2                                                                  |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |          X                                               X               |             
      Erosion                              |       1                                                                  |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |       +                                                                  |             
      Developmental Malformation           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  63                                                               
NTP Experiment-Test: 05705-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 12:50:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 7| 7| 0| 0| 5| 7| 6| 1| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 7| 7| 2| 3| 1| 6| 4| 3| 8| 3| 3| 3| 3| 1| 0| 2| 3| 3| 2| 2| 3| 3| 3| 3|             
                                           | 9| 3| 4| 9| 0| 1| 6| 2| 0| 7| 6| 1| 1| 0| 4| 6| 9| 1| 0| 9| 9| 0| 1| 0| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    50 MG/KG                               | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
     MALE                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Peridontal Tissue, Inflammation,     |                                                                          |             
           Acute                           |       2                                                                  |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Degeneration                         |       1  1              1              1  2     1        1  1        1   |             
      Inflammation, Chronic                |                                                    1                     |             
      Atrium, Pigmentation                 |                                                                          |             
      Atrium, Thrombosis                   |                                                                          |             
      Epicardium, Fibrosis                 |                      3                                                   |             
      Valve, Pigmentation                  |                            1     1              1        1  1  1         |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Subcapsular, Hyperplasia             | 2        2  2        1  3  2  1  2  3  2  2     2  1  1  1  1  2  2  2  2|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  M  +  M  M  M  +  M  M  M  M  M  M  M  M  M  +  +  +  M  M  M  M  M  M|             
      Cyst                                 |                                                       X                  |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Follicle, Cyst                       |                                                          X               |             
      Follicular Cell, Hyperplasia         |                                                                      1   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Coagulating Gland                       |                                                                          |             
      Cyst                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                                                          |             
                                            __________________________________________________________________________|             
   Penis                                   |       +           +           +  +                                       |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                   +     +        +                                       |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Chronic                |                                  3                                       |             
      Duct, Cyst                           |                   X     X                                                |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                 2                        |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |                                                                          |             
      Dilatation                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  64                                                               
NTP Experiment-Test: 05705-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 12:50:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 7| 7| 0| 0| 5| 7| 6| 1| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 7| 7| 2| 3| 1| 6| 4| 3| 8| 3| 3| 3| 3| 1| 0| 2| 3| 3| 2| 2| 3| 3| 3| 3|             
                                           | 9| 3| 4| 9| 0| 1| 6| 2| 0| 7| 6| 1| 1| 0| 4| 6| 9| 1| 0| 9| 9| 0| 1| 0| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    50 MG/KG                               | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
     MALE                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration                         |                      1                                                   |             
      Mineralization                       |                                  1                                       |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Myeloid Cell, Hyperplasia            |       2                                   2                              |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  +  +  +  +  M  +  +  I  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Inguinal, Hyperplasia, Plasma Cell   |                                                                          |             
      Inguinal, Pigmentation               | 1                                                     1           1      |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  M  +  +  I  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |       2                                                                  |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Atrophy, Focal                       |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
          Granulocytic                     |                                           2                              |             
      Hematopoietic Cell Proliferation     |                                                                          |             
          Erythrocytic                     |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Capsule, Fibrosis                    |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  M  +  +  +  +  +  I  +  +  +  +  +  +  M  M  +  +  +  I  +  +  I  +  +|             
      Atrophy                              |                                                                          |             
      Cyst                                 |                            X                                             |             
      Ectopic Parathyroid Gland            |                                                                          |             
      Necrosis                             |       1                                                                  |             
      Epithelial Cell, Hyperplasia         | 2        2                                      2                       2|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  +  +  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                   2      |             
      Inflammation, Acute                  |    3                                                                     |             
      Inflammation, Chronic                |                                                                          |             
      Parasite External                    |                                                                   X      |             
      Prepuce, Abscess                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Melanosis                            |                                     1                                    |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  65                                                               
NTP Experiment-Test: 05705-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 12:50:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 7| 6| 6| 7| 7| 0| 0| 5| 7| 6| 1| 7| 7| 7| 7| 0| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
                             DAY ON TEST   | 2| 7| 7| 2| 3| 1| 6| 4| 3| 8| 3| 3| 3| 3| 1| 0| 2| 3| 3| 2| 2| 3| 3| 3| 3|             
                                           | 9| 3| 4| 9| 0| 1| 6| 2| 0| 7| 6| 1| 1| 0| 4| 6| 9| 1| 0| 9| 9| 0| 1| 0| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    50 MG/KG                               | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
     MALE                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Mineralization                       |       1     1           2  2     1  1  3  3        1  2  2  1     2      |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                   +                                                      |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                2                                                         |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                                                                          |             
      Interstitium, Inflammation, Chronic  |                                                                          |             
      Perivascular, Infiltration Cellular, |                                                                          |             
           Lymphocyte                      |                                                 2                        |             
      Pleura, Fibrosis                     |                      3                                                   |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Exudate                              |       1                             1  2  2        1     1               |             
      Granuloma                            |             1                                                            |             
      Inflammation, Acute                  | 1                    2  1                       1           1            |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Mucosa, Nasolacrimal Duct,           |                                                                          |             
          Hyperplasia                      | 1        1  1           1  1     3        2     1     2  1     1         |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Acute                           |                                                                          |             
      Olfactory Epithelium, Metaplasia     |    1                                                              1      |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Metaplasia, Squamous                 |    1                                                                     |             
      Ulcer, Acute                         |    3                                                                     |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     | +                                                                        |             
      Inflammation, Acute                  |                                                                          |             
      Neovascularization                   | 1                                                                        |             
      Cornea, Necrosis                     |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                  +                                       |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Mineralization                       |                                                                          |             
      Nephropathy                          | 2     1  1  1           1  1     2     1  1     1     1  1  1  1     1  1|             
                                            __________________________________________________________________________|             
   Ureter                                  |                               +                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  66                                                               
NTP Experiment-Test: 05705-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 12:50:12  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 4| 7| 7| 5| 6|                                            |            |
                             DAY ON TEST   | 3| 2| 2| 3| 3| 3| 3| 2| 7| 3|                                            |            |
                                           | 1| 9| 9| 1| 1| 4| 0| 9| 3| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    50 MG/KG                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
     MALE                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Ulcer, Acute                         |                                                                          |      1  4.0|
                                            __________________________________________________________________________|____________|
   Gallbladder                             | I  +  +  +  +  +  +  +  +  A                                             |  52        |
      Cyst                                 |                                                                          |      1     |
      Inflammation, Chronic                |                   1                                                      |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +                                             |  58        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +  +  +  +  +  +                                             |  55        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Infiltration Cellular, Plasma Cell   |                                                                          |      1  2.0|
      Parasite Metazoan                    |                                                                          |      4     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Inflammation, Acute                  |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +  +  +  +  +  +                                             |  56        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +  +  +  +  +  A                                             |  53        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +  +  +  +  +  +                                             |  54        |
      Amyloid Deposition                   |                                                                          |      1  1.0|
      Parasite Metazoan                    |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +  +  +  +  +  +                                             |  56        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Congestion                           |                            4                                             |      1  4.0|
      Cytoplasmic Alteration               |                1                                                         |      1  1.0|
      Infarct                              | 4                                                                        |      2  2.5|
      Inflammation, Chronic                |                                                                          |      4  1.0|
      Necrosis                             |                                                                          |      4  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                                          |   1        |
      Artery, Perivascular, Inflammation,  |                                                                          |            |
           Chronic                         |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Atrophy                              |                                                                          |      1  1.0|
      Cyst                                 |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  M                                             |  57        |
      Atrophy                              |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cyst                                 | X                                                                        |      1     |
      Hyperplasia, Focal, Squamous         |                                                                          |      2  2.0|
      Ulcer                                |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Cyst                                 |                         X                                                |      3     |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  67                                                               
NTP Experiment-Test: 05705-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 12:50:12  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 4| 7| 7| 5| 6|                                            |            |
                             DAY ON TEST   | 3| 2| 2| 3| 3| 3| 3| 2| 7| 3|                                            |            |
                                           | 1| 9| 9| 1| 1| 4| 0| 9| 3| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    50 MG/KG                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
     MALE                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Erosion                              |                            1                                             |      3  1.0|
      Inflammation, Acute                  |                                                                          |      1  1.0|
      Inflammation, Chronic                |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |    +                                                                     |   2        |
      Developmental Malformation           |    X                                                                     |      1     |
      Peridontal Tissue, Inflammation,     |                                                                          |            |
           Acute                           |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +                                             |  58        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Degeneration                         |       1     1                                                            |     16  1.1|
      Inflammation, Chronic                | 2                                                                        |      3  1.3|
      Atrium, Pigmentation                 | 1                                                                        |      1  1.0|
      Atrium, Thrombosis                   |                                                                          |      1     |
      Epicardium, Fibrosis                 |                                                                          |      1  3.0|
      Valve, Pigmentation                  |                      1                                                   |     10  1.1|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Hyperplasia                          |                                                                          |      1  1.0|
      Subcapsular, Hyperplasia             | 1  1  1  2  1     2  1                                                   |     48  1.7|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | I  M  +  M  M  +  +  M  M  +                                             |  19        |
      Cyst                                 |                                                                          |      2     |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +  +  +  +  +  +                                             |  57        |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Follicle, Cyst                       |          X                                                               |      3     |
      Follicular Cell, Hyperplasia         |          2                                                               |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Coagulating Gland                       |                      +                                                   |   1        |
      Cyst                                 |                      X                                                   |      1     |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +                                             |  60        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  68                                                               
NTP Experiment-Test: 05705-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 12:50:12  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 4| 7| 7| 5| 6|                                            |            |
                             DAY ON TEST   | 3| 2| 2| 3| 3| 3| 3| 2| 7| 3|                                            |            |
                                           | 1| 9| 9| 1| 1| 4| 0| 9| 3| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    50 MG/KG                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
     MALE                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Dilatation                           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Penis                                   |                                                                          |   8        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +                                                                        |   6        |
      Hemorrhage                           |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                                                          |      2  3.0|
      Duct, Cyst                           | X                                                                        |      4     |
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Fibrosis                             |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |             +                                                            |   2        |
      Dilatation                           |             2                                                            |      1  2.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Degeneration                         |                                                                          |      4  1.3|
      Mineralization                       |                            1                                             |      8  1.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Myeloid Cell, Hyperplasia            |                                                                          |      4  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  +  +  +  +  +                                             |  55        |
      Inguinal, Hyperplasia, Plasma Cell   |                                                                          |      2  3.5|
      Inguinal, Pigmentation               | 1  1     1  2              2                                             |      9  1.4|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  +  +  +  +  +                                             |  55        |
      Inflammation, Acute                  |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Atrophy, Focal                       |                      1                                                   |      1  1.0|
      Hematopoietic Cell Proliferation     |                                                                          |            |
          Granulocytic                     |                                                                          |      3  2.0|
      Hematopoietic Cell Proliferation     |                                                                          |            |
          Erythrocytic                     |                                                                          |      1  3.0|
      Hyperplasia, Lymphoid                |       2                                                                  |      2  2.0|
      Capsule, Fibrosis                    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  M  +  M  +  +  M  M                                             |  42        |
      Atrophy                              |                                                                          |      1  3.0|
      Cyst                                 |       X                                                                  |      3     |
      Ectopic Parathyroid Gland            |       X                                                                  |      3     |
      Necrosis                             |                                                                          |      1  1.0|
      Epithelial Cell, Hyperplasia         |    1                                                                     |      7  1.7|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  +  M  +  M  M  M  +  M  M                                             |   9        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  69                                                               
NTP Experiment-Test: 05705-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 12:50:12  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 4| 7| 7| 5| 6|                                            |            |
                             DAY ON TEST   | 3| 2| 2| 3| 3| 3| 3| 2| 7| 3|                                            |            |
                                           | 1| 9| 9| 1| 1| 4| 0| 9| 3| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    50 MG/KG                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
     MALE                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Fibrosis                             |                                                                          |      2  2.5|
      Inflammation, Acute                  |                                                                          |      1  3.0|
      Inflammation, Chronic                |                   1                                                      |      1  1.0|
      Parasite External                    |                                                                          |      3     |
      Prepuce, Abscess                     |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  58        |
      Congestion                           |                                                                          |      1  1.0|
      Melanosis                            |                                                                          |      1  1.0|
      Mineralization                       | 3  2  1  1        2  2                                                   |     34  1.8|
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Congestion                           |                            3                                             |      2  3.0|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |                   1                                                      |      4  2.0|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |                                                                          |      3  1.3|
      Interstitium, Inflammation, Chronic  | 2                                                                        |      2  1.5|
      Perivascular, Infiltration Cellular, |                                                                          |            |
           Lymphocyte                      |                                                                          |      6  1.3|
      Pleura, Fibrosis                     |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Exudate                              | 1     2  1     1  1                                                      |     18  1.3|
      Granuloma                            |                                                                          |      1  1.0|
      Inflammation, Acute                  |                1                                                         |      7  1.1|
      Inflammation, Chronic                |                                                                          |      2  1.5|
      Inflammation, Chronic Active         | 2        1                                                               |      2  1.5|
      Mucosa, Nasolacrimal Duct,           |                                                                          |            |
          Hyperplasia                      | 1  2  1  1  1  1  1                                                      |     28  1.3|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Acute                           |                                                                          |      2  1.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  70                                                               
NTP Experiment-Test: 05705-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 12:50:12  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 7| 7| 7| 7| 7| 4| 7| 7| 5| 6|                                            |            |
                             DAY ON TEST   | 3| 2| 2| 3| 3| 3| 3| 2| 7| 3|                                            |            |
                                           | 1| 9| 9| 1| 1| 4| 0| 9| 3| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|                                            |      A     |
    50 MG/KG                               | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      L     |
     MALE                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Olfactory Epithelium, Metaplasia     |                                                                          |      3  1.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Metaplasia, Squamous                 |                                                                          |      1  1.0|
      Ulcer, Acute                         |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                                          |   3        |
      Inflammation, Acute                  |                                                                          |      1  1.0|
      Neovascularization                   |                                                                          |      2  2.0|
      Cornea, Necrosis                     |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   3        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Cyst                                 |          X                                                               |      4     |
      Mineralization                       |    1                                                                     |      2  1.0|
      Nephropathy                          | 1  1  1     1     1  1                                                   |     38  1.1|
                                            __________________________________________________________________________|____________|
   Ureter                                  |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +                                             |  58        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  71                                                               
NTP Experiment-Test: 05705-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 12:50:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 0| 1| 2| 4| 7| 7| 6| 4| 7| 5| 5| 7| 6| 7| 7| 1| 3| 5| 4| 4| 0| 6| 7| 7| 4|             
                             DAY ON TEST   | 5| 0| 6| 3| 3| 3| 7| 4| 2| 9| 2| 3| 2| 2| 3| 3| 2| 0| 4| 3| 6| 6| 3| 3| 6|             
                                           | 9| 4| 8| 4| 0| 1| 9| 7| 9| 9| 8| 1| 3| 9| 0| 5| 4| 4| 3| 1| 2| 9| 1| 0| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    100MG/KG                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
     MALE                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | +  I  +  +  +  +  A  A  +  +  M  +  M  +  +  A  +  A  A  A  A  +  +  +  M|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +  +  +  A  +  +  A  +  +  +  +  +  A  +  +  A  +  +  A  +  A  +  +  +  +|             
      Diverticulum                         |                                                                          |             
      Parasite Metazoan                    |                                                    X                     |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Parasite Metazoan                    |                            X                                   X         |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +  M  +  +  +  +  A  +  +  +  +  +  +  +  +  A  +  +  M  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | A  A  +  +  +  +  A  +  +  +  +  +  A  +  +  A  +  A  A  +  A  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | A  A  A  +  +  +  A  +  +  +  +  +  A  +  +  A  +  A  A  +  A  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | A  A  +  A  +  +  A  +  +  +  +  +  A  +  +  A  +  A  A  A  A  +  +  +  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | A  A  +  A  +  +  A  +  +  +  +  +  A  +  +  A  +  A  A  A  A  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                  X                                       |             
      Clear Cell Focus                     |                                                                          |             
      Congestion                           |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |                                                                      3   |             
      Necrosis                             |                                     2                                    |             
      Bile Duct, Cyst                      |                                                                          |             
      Centrilobular, Fatty Change          |                                                                          |             
      Hepatocyte, Cytomegaly, Diffuse      |                                                                      3   |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                  1     1                          1      |             
      Hyperplasia, Focal                   |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hyperplasia, Focal, Squamous         |                2                                2  3                 4   |             
      Hyperplasia, Multifocal, Squamous    |                                  3                                2      |             
      Inflammation, Acute, Multifocal      |                                  2                                       |             
      Inflammation, Chronic Active         |                                                                          |             
      Ulcer                                |                                  2                                       |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Erosion                              |          1           2                                   1              1|             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Tooth                                   |                                                                          |             
      Peridontal Tissue, Inflammation,     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  72                                                               
NTP Experiment-Test: 05705-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 12:50:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 0| 1| 2| 4| 7| 7| 6| 4| 7| 5| 5| 7| 6| 7| 7| 1| 3| 5| 4| 4| 0| 6| 7| 7| 4|             
                             DAY ON TEST   | 5| 0| 6| 3| 3| 3| 7| 4| 2| 9| 2| 3| 2| 2| 3| 3| 2| 0| 4| 3| 6| 6| 3| 3| 6|             
                                           | 9| 4| 8| 4| 0| 1| 9| 7| 9| 9| 8| 1| 3| 9| 0| 5| 4| 4| 3| 1| 2| 9| 1| 0| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    100MG/KG                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
     MALE                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
           Chronic                         |                                                                          |             
      Pulp, Inflammation, Acute            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess, Chronic Active              |                                                                          |             
      Degeneration                         |          3     2  2  2     1        2              2           2        2|             
      Mineralization                       |                               3                                          |             
      Atrium, Thrombosis                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                                                          |             
      Cytoplasmic Alteration, Focal        |                                                                      2   |             
      Hyperplasia                          |             1                                                            |             
      Hypertrophy, Focal                   |                                                    1                     |             
      Subcapsular, Hyperplasia             |    1  1  2  1  2  1  2  4  1  2  1  1  3  4  1  2  2  1        2  4  2  1|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
      Hyperplasia, Focal                   |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  M  M  +  +  +  M  M  +  M  +  M  M  +  +  +  +  +  +  M  M  M  +  +  M|             
      Cyst                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Cyst                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Follicle, Cyst                       |                                                                          |             
      Follicular Cell, Hyperplasia         |                2                                                         |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Penis                                   |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |    +                       +           +     +        +                  |             
      Fibrosis                             |                                                                          |             
      Inflammation, Chronic                |                            1                                             |             
      Duct, Cyst                           |    4                       X                 X                           |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +|             
      Fibrosis, Focal                      |                2                                                         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  73                                                               
NTP Experiment-Test: 05705-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 12:50:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 0| 1| 2| 4| 7| 7| 6| 4| 7| 5| 5| 7| 6| 7| 7| 1| 3| 5| 4| 4| 0| 6| 7| 7| 4|             
                             DAY ON TEST   | 5| 0| 6| 3| 3| 3| 7| 4| 2| 9| 2| 3| 2| 2| 3| 3| 2| 0| 4| 3| 6| 6| 3| 3| 6|             
                                           | 9| 4| 8| 4| 0| 1| 9| 7| 9| 9| 8| 1| 3| 9| 0| 5| 4| 4| 3| 1| 2| 9| 1| 0| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    100MG/KG                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
     MALE                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Inflammation, Acute                  |                            2                                             |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |                               +                 +                        |             
      Dilatation                           |                                                                          |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration                         |                      1        1                                         2|             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |                                                                          |             
      Mineralization                       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  M  +  M  +  +  +  +  +  M  +|             
      Iliac, Hyperplasia, Plasma Cell      |                                                                          |             
      Inguinal, Hyperplasia, Plasma Cell   |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  +  +  M  +  +  +  +  +  +  +  +  M  +  +  M  +  M  +  +  +  +  +  M  +|             
      Congestion, Focal                    |                                                                1         |             
      Hematopoietic Cell Proliferation     |                                                                          |             
          Erythrocytic                     |                                                                2         |             
      Hyperplasia, Lymphoid                |                                        3                                 |             
      Hyperplasia, Plasma Cell             |                                                                          |             
      Infiltration Cellular, Histiocyte    |                                                                          |             
      Pigmentation, Hemosiderin            |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
          Erythrocytic                     |    3                                                                     |             
      Hyperplasia, Lymphoid                |       3     3                          2                                 |             
      Hyperplasia, Plasma Cell             |                            2                                   2         |             
      Infiltration Cellular, Histiocyte    |                                                                          |             
      Pigmentation, Hemosiderin            |                                                                      2   |             
      Capsule, Fibrosis                    |                                  2                                       |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  +  +  M  +  +  +  +  +  M  M  +  M  +  +  +  +  +  +  +  M  M  +  +  M|             
      Atrophy                              |                                                    2                     |             
      Cyst                                 |       X                          X        X                              |             
      Necrosis                             |                                                                          |             
      Epithelial Cell, Hyperplasia         |             2           2                       3     2                  |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  M  M  M  M  M  M  M  M  M  M  +  M  M  M  M  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                                                          |             
      Fibrosis                             |                                                                2         |             
      Inflammation, Acute                  | 2                                                                        |             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  74                                                               
NTP Experiment-Test: 05705-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 12:50:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 0| 1| 2| 4| 7| 7| 6| 4| 7| 5| 5| 7| 6| 7| 7| 1| 3| 5| 4| 4| 0| 6| 7| 7| 4|             
                             DAY ON TEST   | 5| 0| 6| 3| 3| 3| 7| 4| 2| 9| 2| 3| 2| 2| 3| 3| 2| 0| 4| 3| 6| 6| 3| 3| 6|             
                                           | 9| 4| 8| 4| 0| 1| 9| 7| 9| 9| 8| 1| 3| 9| 0| 5| 4| 4| 3| 1| 2| 9| 1| 0| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    100MG/KG                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
     MALE                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Parasite External                    |                   X        X                                             |             
      Ulcer                                |                                  3                                       |             
      Epithelium, Atrophy                  |                                     2                                    |             
      Hair Follicle, Atrophy               |                                                                2         |             
      Prepuce, Inflammation, Acute         |                            3                                             |             
      Prepuce, Ulcer                       |    4                                         2                           |             
      Scrotal, Ulcer, Acute                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fracture Healed                      |                                  X                                       |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                            +                                             |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |       1  1  1  2     1  1  2  3  2  2     2                       2  2   |             
                                            __________________________________________________________________________|             
   Spinal Cord                             | +                                                           +            |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           | 2                                            4  2  1     1              2|             
      Hemorrhage                           |                                                       3                  |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                                                          |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                2                                                         |             
      Interstitium, Inflammation, Chronic  |                1                                            3            |             
      Perivascular, Infiltration Cellular, |                                                                          |             
           Lymphocyte                      |                2                                                         |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Exudate                              |       3  1     1              2  1           1     1              2  1  1|             
      Inflammation, Acute                  |                   1     1  1        3  1  2     3     2     3  1         |             
      Mucosa, Turbinate, Hyperplasia       |                                                                          |             
      Mucosa, Nasolacrimal Duct,           |                                                                          |             
          Hyperplasia                      |    3                 2  1  1     1        1     1     2              1  2|             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Acute                           |                   3  2                                            2      |             
      Olfactory Epithelium, Metaplasia     |                                                                   2      |             
      Turbinate, Atrophy                   |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                                                             3            |             
      Inflammation, Chronic                |                1                                                         |             
      Inflammation, Chronic Active         |                                     1                                    |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  75                                                               
NTP Experiment-Test: 05705-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 12:50:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 0| 1| 2| 4| 7| 7| 6| 4| 7| 5| 5| 7| 6| 7| 7| 1| 3| 5| 4| 4| 0| 6| 7| 7| 4|             
                             DAY ON TEST   | 5| 0| 6| 3| 3| 3| 7| 4| 2| 9| 2| 3| 2| 2| 3| 3| 2| 0| 4| 3| 6| 6| 3| 3| 6|             
                                           | 9| 4| 8| 4| 0| 1| 9| 7| 9| 9| 8| 1| 3| 9| 0| 5| 4| 4| 3| 1| 2| 9| 1| 0| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    100MG/KG                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
     MALE                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                +                                                        +|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                   X              X                 X                     |             
      Inflammation, Acute                  |                            3                                             |             
      Mineralization                       |                                                                          |             
      Nephropathy                          |          1  2  1        3        1  1  1  1                    1  1  1  1|             
      Capsule, Fibrosis                    |                                                                          |             
      Renal Tubule, Necrosis, Acute        |                      1        4                          2               |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  I  +  +  +  +  +  +  +  +  +|             
      Ectopic Tissue                       |                                                 X                        |             
      Inflammation, Acute                  |                            4                                             |             
      Transitional Epithelium, Hyperplasia,|                                                                          |             
           Focal                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  76                                                               
NTP Experiment-Test: 05705-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 12:50:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 4| 7| 7| 5| 6| 7| 7| 5| 4| 7| 5| 7| 7| 5| 1| 7| 7| 7| 5| 0| 1| 4| 4| 7|             
                             DAY ON TEST   | 6| 6| 2| 3| 8| 9| 2| 3| 8| 9| 2| 4| 3| 3| 5| 9| 1| 3| 2| 4| 0| 4| 2| 2| 2|             
                                           | 7| 8| 9| 0| 8| 5| 9| 1| 1| 7| 9| 1| 0| 1| 3| 0| 1| 0| 9| 5| 4| 9| 8| 4| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    100MG/KG                               | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
     MALE                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Gallbladder                             | A  A  +  +  A  +  +  +  +  +  +  +  M  +  +  M  +  +  +  +  A  +  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | A  +  +  M  A  +  M  +  A  +  +  +  +  +  +  A  +  +  +  +  A  +  A  +  +|             
      Diverticulum                         |                2                                                         |             
      Parasite Metazoan                    |                X                                                         |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Inflammation, Chronic Active         |                1                                                         |             
      Parasite Metazoan                    |       X  X     X  X     X  X                                             |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | M  +  +  +  M  +  +  +  M  +  +  +  +  +  +  +  A  +  +  +  M  +  +  +  +|             
      Parasite Metazoan                    |                X                                                         |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +  +  +  +  A  +  +  +  A  +  +  +  +  +  +  A  +  +  +  +  A  A  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +  +  +  +  A  +  +  +  A  A  +  +  +  +  +  A  +  +  +  +  M  A  A  A  A|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | A  +  +  +  A  +  +  +  A  +  +  A  +  +  A  A  +  +  +  +  A  A  A  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | A  +  +  +  A  +  +  +  A  +  +  +  +  +  +  A  +  +  +  +  A  A  A  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   | +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                                                          |             
      Clear Cell Focus                     |                                                                   X      |             
      Congestion                           |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                 2                        |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |                                                    2                     |             
      Necrosis                             |                2                                3                        |             
      Bile Duct, Cyst                      |                      X                                                   |             
      Centrilobular, Fatty Change          |                                                          1               |             
      Hepatocyte, Cytomegaly, Diffuse      |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Atrophy                              |                                     2                                    |             
      Hyperplasia, Focal                   |                                                                      3   |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hyperplasia, Focal, Squamous         |                      2        3                                          |             
      Hyperplasia, Multifocal, Squamous    |          2                             1                                 |             
      Inflammation, Acute, Multifocal      |                                                                          |             
      Inflammation, Chronic Active         |                               2                                          |             
      Ulcer                                |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +  M  +  A  +  +|             
      Cyst                                 |                                                                          |             
      Erosion                              |                                  1        1     2                        |             
      Inflammation, Acute                  |                         1                                                |             
                                            __________________________________________________________________________|             
   Tooth                                   |       +                                               +                  |             
      Peridontal Tissue, Inflammation,     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  77                                                               
NTP Experiment-Test: 05705-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 12:50:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 4| 7| 7| 5| 6| 7| 7| 5| 4| 7| 5| 7| 7| 5| 1| 7| 7| 7| 5| 0| 1| 4| 4| 7|             
                             DAY ON TEST   | 6| 6| 2| 3| 8| 9| 2| 3| 8| 9| 2| 4| 3| 3| 5| 9| 1| 3| 2| 4| 0| 4| 2| 2| 2|             
                                           | 7| 8| 9| 0| 8| 5| 9| 1| 1| 7| 9| 1| 0| 1| 3| 0| 1| 0| 9| 5| 4| 9| 8| 4| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    100MG/KG                               | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
     MALE                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
           Chronic                         |       1                                                                  |             
      Pulp, Inflammation, Acute            |                                                       1                  |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Heart                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Abscess, Chronic Active              | 4                                                                        |             
      Degeneration                         |    1           2        3  2                    1  1                    3|             
      Mineralization                       |                         1                                2               |             
      Atrium, Thrombosis                   |                                                                         X|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                                                          |             
      Cytoplasmic Alteration, Focal        |                                                                          |             
      Hyperplasia                          |                               1                       1                  |             
      Hypertrophy, Focal                   |                                                                          |             
      Subcapsular, Hyperplasia             | 1  1  1  1     2  1  2     1  2  2  3  2  1     3  1  2  1     1     1  1|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                           2                             1|             
      Hyperplasia, Focal                   |                            3                                             |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M  +  +  +  +  +  +  +  M  M  +  M  +  M  +  M  +  +  M  +  +  M  +  M  +|             
      Cyst                                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +  +  +  I  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |             2                                                            |             
      Cyst                                 |                   X        X                                             |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +  +  +  +  +  +  +  +  M  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Follicle, Cyst                       |                                                                         X|             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Penis                                   |                                                                   +      |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |                                                                   +  +   |             
      Fibrosis                             |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Duct, Cyst                           |                                                                      X   |             
                                            __________________________________________________________________________|             
   Prostate                                | +  +  +  +  +  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fibrosis, Focal                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  78                                                               
NTP Experiment-Test: 05705-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 12:50:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 4| 7| 7| 5| 6| 7| 7| 5| 4| 7| 5| 7| 7| 5| 1| 7| 7| 7| 5| 0| 1| 4| 4| 7|             
                             DAY ON TEST   | 6| 6| 2| 3| 8| 9| 2| 3| 8| 9| 2| 4| 3| 3| 5| 9| 1| 3| 2| 4| 0| 4| 2| 2| 2|             
                                           | 7| 8| 9| 0| 8| 5| 9| 1| 1| 7| 9| 1| 0| 1| 3| 0| 1| 0| 9| 5| 4| 9| 8| 4| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    100MG/KG                               | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
     MALE                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Inflammation, Acute                  |                                                                3         |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |                            +                                   +         |             
      Dilatation                           |                                                                3         |             
                                            __________________________________________________________________________|             
   Testes                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Degeneration                         |                                                          2               |             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |                   1                                                      |             
      Mineralization                       |                            1                                             |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  +  +  +  +|             
      Iliac, Hyperplasia, Plasma Cell      |                                                                3         |             
      Inguinal, Hyperplasia, Plasma Cell   |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +  M  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  A  A  +  +  +|             
      Congestion, Focal                    |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
          Erythrocytic                     |                                                                          |             
      Hyperplasia, Lymphoid                |                      3                                                   |             
      Hyperplasia, Plasma Cell             |          2                                                               |             
      Infiltration Cellular, Histiocyte    |                                                                          |             
      Pigmentation, Hemosiderin            |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
          Erythrocytic                     |                4        3                       3              3         |             
      Hyperplasia, Lymphoid                | 4                             2                                          |             
      Hyperplasia, Plasma Cell             | 3                                                                        |             
      Infiltration Cellular, Histiocyte    |                                                                          |             
      Pigmentation, Hemosiderin            |                                                                          |             
      Capsule, Fibrosis                    |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +  M  +  +  M  M  +  +  M  M  +  M  +  +  +  M  M  +  +  +  +  +  M  +  M|             
      Atrophy                              |                                                                          |             
      Cyst                                 |                   X                                                      |             
      Necrosis                             |                                                                      2   |             
      Epithelial Cell, Hyperplasia         |       1  2                                               1               |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | M  M  M  +  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Skin                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Acanthosis                           |                                                                          |             
      Fibrosis                             |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |                   1                                                     2|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  79                                                               
NTP Experiment-Test: 05705-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 12:50:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 4| 7| 7| 5| 6| 7| 7| 5| 4| 7| 5| 7| 7| 5| 1| 7| 7| 7| 5| 0| 1| 4| 4| 7|             
                             DAY ON TEST   | 6| 6| 2| 3| 8| 9| 2| 3| 8| 9| 2| 4| 3| 3| 5| 9| 1| 3| 2| 4| 0| 4| 2| 2| 2|             
                                           | 7| 8| 9| 0| 8| 5| 9| 1| 1| 7| 9| 1| 0| 1| 3| 0| 1| 0| 9| 5| 4| 9| 8| 4| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    100MG/KG                               | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
     MALE                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Parasite External                    |                         X                                               X|             
      Ulcer                                |                3                                            3           3|             
      Epithelium, Atrophy                  |                                                                          |             
      Hair Follicle, Atrophy               |                                                                          |             
      Prepuce, Inflammation, Acute         |                                                                         1|             
      Prepuce, Ulcer                       |                                                                4         |             
      Scrotal, Ulcer, Acute                |                                                                      3   |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Fracture Healed                      |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Mineralization                       |       2  1     2     2                    2     1     2           2  1   |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                             +            |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Congestion                           |             2           1                    3                           |             
      Hemorrhage                           |                                        1                                 |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |             3                                                           2|             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                                     3                                   1|             
      Interstitium, Inflammation, Chronic  |                                                                          |             
      Perivascular, Infiltration Cellular, |                                                                          |             
           Lymphocyte                      |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Exudate                              |    1     1     1           3     2           4              1  1     1   |             
      Inflammation, Acute                  | 1     1  1        1  1  2                 1           1                 1|             
      Mucosa, Turbinate, Hyperplasia       |          2                                                               |             
      Mucosa, Nasolacrimal Duct,           |                                                                          |             
          Hyperplasia                      | 3              2        1  2     2     2           1  1              2  2|             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Acute                           |                                                                          |             
      Olfactory Epithelium, Metaplasia     |          3                                                               |             
      Turbinate, Atrophy                   |                                                       2                  |             
                                            __________________________________________________________________________|             
   Trachea                                 | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  80                                                               
NTP Experiment-Test: 05705-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 12:50:12  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 4| 7| 7| 5| 6| 7| 7| 5| 4| 7| 5| 7| 7| 5| 1| 7| 7| 7| 5| 0| 1| 4| 4| 7|             
                             DAY ON TEST   | 6| 6| 2| 3| 8| 9| 2| 3| 8| 9| 2| 4| 3| 3| 5| 9| 1| 3| 2| 4| 0| 4| 2| 2| 2|             
                                           | 7| 8| 9| 0| 8| 5| 9| 1| 1| 7| 9| 1| 0| 1| 3| 0| 1| 0| 9| 5| 4| 9| 8| 4| 6|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    100MG/KG                               | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
     MALE                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM - cont              |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                    X                     |             
      Inflammation, Acute                  |                         1                                                |             
      Mineralization                       |                      1                                   2               |             
      Nephropathy                          | 1  1     1        1  2     2  2        1        2     1              2   |             
      Capsule, Fibrosis                    |                   2                                                      |             
      Renal Tubule, Necrosis, Acute        |    1                                                     3               |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +  +  +  +  A  +  +  +  A  +  +  +  +  +  +  +  +  +  +  +  A  +  A  +  +|             
      Ectopic Tissue                       |                                                                          |             
      Inflammation, Acute                  |                                                                4         |             
      Transitional Epithelium, Hyperplasia,|                                                                          |             
           Focal                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  81                                                               
NTP Experiment-Test: 05705-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 12:50:12  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 7| 7| 6| 4| 0| 4| 5| 7| 7|                                            |            |
                             DAY ON TEST   | 6| 2| 3| 4| 9| 1| 4| 9| 3| 2|                                            |            |
                                           | 3| 9| 1| 5| 5| 8| 7| 4| 0| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      A     |
    100MG/KG                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |      L     |
     MALE                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Gallbladder                             | +  +  +  +  A  M  M  +  +  +                                             |  39        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +  +  +  +  +  +                                             |  57        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | A  +  +  +  +  A  +  +  +  +                                             |  44        |
      Diverticulum                         |                                                                          |      1  2.0|
      Parasite Metazoan                    |                                                                          |      2     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | A  +  +  +  +  +  +  +  +  +                                             |  56        |
      Inflammation, Chronic Active         |                                                                          |      1  1.0|
      Parasite Metazoan                    |             X                                                            |      9     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +  A  +  +  +  +                                             |  50        |
      Parasite Metazoan                    |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | A  +  +  +  +  A  +  +  +  +                                             |  44        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | A  +  +  +  +  A  +  A  +  +                                             |  39        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | A  +  +  +  A  A  +  +  +  +                                             |  37        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | A  +  +  +  A  A  +  +  +  +                                             |  40        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Basophilic Focus                     |                                                                          |      1     |
      Clear Cell Focus                     |                                                                          |      1     |
      Congestion                           | 1                                                                        |      1  1.0|
      Hematopoietic Cell Proliferation     |                                                                          |      1  2.0|
      Inflammation, Acute                  |                      4  1                                                |      2  2.5|
      Inflammation, Chronic                |                                                                          |      2  2.5|
      Necrosis                             |       3              4                                                   |      5  2.8|
      Bile Duct, Cyst                      |                                                                          |      1     |
      Centrilobular, Fatty Change          |                                                                          |      1  1.0|
      Hepatocyte, Cytomegaly, Diffuse      |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | A  +  +  +  +  +  +  +  +  +                                             |  57        |
      Atrophy                              |                                                                          |      4  1.3|
      Hyperplasia, Focal                   |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +  +  +  +  +  +                                             |  59        |
      Cyst                                 |       X                                                                  |      1     |
      Hyperplasia, Focal, Squamous         |       1                    1                                             |      8  2.3|
      Hyperplasia, Multifocal, Squamous    |    3                                                                     |      5  2.2|
      Inflammation, Acute, Multifocal      |                                                                          |      1  2.0|
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
      Ulcer                                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | A  +  +  +  +  +  +  +  +  +                                             |  54        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  82                                                               
NTP Experiment-Test: 05705-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 12:50:12  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 7| 7| 6| 4| 0| 4| 5| 7| 7|                                            |            |
                             DAY ON TEST   | 6| 2| 3| 4| 9| 1| 4| 9| 3| 2|                                            |            |
                                           | 3| 9| 1| 5| 5| 8| 7| 4| 0| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      A     |
    100MG/KG                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |      L     |
     MALE                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Cyst                                 |       X                                                                  |      1     |
      Erosion                              |                2                                                         |      8  1.4|
      Inflammation, Acute                  |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Tooth                                   |                                                                          |   2        |
      Peridontal Tissue, Inflammation,     |                                                                          |            |
           Chronic                         |                                                                          |      1  1.0|
      Pulp, Inflammation, Acute            |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +  +  +  +  +  +                                             |  59        |
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Abscess, Chronic Active              |                                                                          |      1  4.0|
      Degeneration                         |       2  3  2                                                            |     19  2.0|
      Mineralization                       |                                                                          |      3  2.0|
      Atrium, Thrombosis                   |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Basophilic Focus                     |       X                                                                  |      1     |
      Cytoplasmic Alteration, Focal        |                                                                          |      1  2.0|
      Hyperplasia                          |                                                                          |      3  1.0|
      Hypertrophy, Focal                   |                                                                          |      1  1.0|
      Subcapsular, Hyperplasia             |    1  2  1        1  2  1  1                                             |     49  1.6|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Fibrosis                             |                                                                          |      2  1.5|
      Hyperplasia, Focal                   |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +  M  +  +  +  +                                             |  58        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  +  +  M  M  +  M  M  +                                             |  35        |
      Cyst                                 |          X                                                               |      1     |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  M  +  +  +  +  +  +                                             |  56        |
      Congestion                           |                                                                          |      1  2.0|
      Cyst                                 |                                                                          |      2     |
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | A  +  +  +  +  +  +  +  +  +                                             |  57        |
      Follicle, Cyst                       |                      X                                                   |      2     |
      Follicular Cell, Hyperplasia         |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  83                                                               
NTP Experiment-Test: 05705-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 12:50:12  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 7| 7| 6| 4| 0| 4| 5| 7| 7|                                            |            |
                             DAY ON TEST   | 6| 2| 3| 4| 9| 1| 4| 9| 3| 2|                                            |            |
                                           | 3| 9| 1| 5| 5| 8| 7| 4| 0| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      A     |
    100MG/KG                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |      L     |
     MALE                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Penis                                   |                                                                          |   1        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |             +                                                            |   8        |
      Fibrosis                             |             3                                                            |      1  3.0|
      Inflammation, Chronic                |                                                                          |      1  1.0|
      Duct, Cyst                           |                                                                          |      4  4.0|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  M  +  +  +  +  +                                             |  57        |
      Fibrosis, Focal                      |                                                                          |      1  2.0|
      Inflammation, Acute                  |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |             +                                                            |   5        |
      Dilatation                           |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Degeneration                         |                                                                          |      4  1.5|
      Infiltration Cellular, Focal,        |                                                                          |            |
          Lymphocyte                       |                                                                          |      1  1.0|
      Mineralization                       |                            1                                             |      2  1.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +  +  +  +  +  +                                             |  60        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +  A  M  +  +  +                                             |  51        |
      Iliac, Hyperplasia, Plasma Cell      |                                                                          |      1  3.0|
      Inguinal, Hyperplasia, Plasma Cell   |          3                                                               |      1  3.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +  A  M  +  +  +                                             |  50        |
      Congestion, Focal                    |                                                                          |      1  1.0|
      Hematopoietic Cell Proliferation     |                                                                          |            |
          Erythrocytic                     |                                                                          |      1  2.0|
      Hyperplasia, Lymphoid                |                                                                          |      2  3.0|
      Hyperplasia, Plasma Cell             |                                                                          |      1  2.0|
      Infiltration Cellular, Histiocyte    |                      3                                                   |      1  3.0|
      Pigmentation, Hemosiderin            |                      3                                                   |      1  3.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cyst                                 |       X                                                                  |      1     |
      Hematopoietic Cell Proliferation     |                                                                          |            |
          Erythrocytic                     |       4                                                                  |      6  3.3|
      Hyperplasia, Lymphoid                |                                                                          |      5  2.8|
      Hyperplasia, Plasma Cell             |                                                                          |      3  2.3|
      Infiltration Cellular, Histiocyte    |                      3                                                   |      1  3.0|
      Pigmentation, Hemosiderin            |                      4                                                   |      2  3.0|
      Capsule, Fibrosis                    |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  84                                                               
NTP Experiment-Test: 05705-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 12:50:12  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 7| 7| 6| 4| 0| 4| 5| 7| 7|                                            |            |
                             DAY ON TEST   | 6| 2| 3| 4| 9| 1| 4| 9| 3| 2|                                            |            |
                                           | 3| 9| 1| 5| 5| 8| 7| 4| 0| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      A     |
    100MG/KG                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |      L     |
     MALE                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  M  M  M  +  M  M  +  +                                             |  38        |
      Atrophy                              |                                                                          |      1  2.0|
      Cyst                                 |                                                                          |      4     |
      Necrosis                             |                                                                          |      1  2.0|
      Epithelial Cell, Hyperplasia         |                         1                                                |      8  1.8|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | M  M  M  M  M  M  M  +  M  M                                             |   3        |
                                            __________________________________________________________________________|____________|
   Skin                                    | I  +  +  +  +  +  +  +  +  +                                             |  59        |
      Acanthosis                           |       2  2                                                               |      2  2.0|
      Fibrosis                             |       3                                                                  |      2  2.5|
      Inflammation, Acute                  |          2                                                               |      2  2.0|
      Inflammation, Chronic                |                                                                          |      2  1.5|
      Parasite External                    |       X  X  X                                                            |      7     |
      Ulcer                                |                                                                          |      4  3.0|
      Epithelium, Atrophy                  |                                                                          |      1  2.0|
      Hair Follicle, Atrophy               |       1                                                                  |      2  1.5|
      Prepuce, Inflammation, Acute         |                                                                          |      2  2.0|
      Prepuce, Ulcer                       |                                                                          |      3  3.3|
      Scrotal, Ulcer, Acute                |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Fracture Healed                      |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Mineralization                       |       3  2        1  2  1  3                                             |     28  1.8|
                                            __________________________________________________________________________|____________|
   Spinal Cord                             | +                                                                        |   4        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Congestion                           | 4              4                                                         |     11  2.4|
      Hemorrhage                           |                                                                          |      2  2.0|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |                                                                          |      2  2.5|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |                                                                          |      3  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  85                                                               
NTP Experiment-Test: 05705-01                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 12:50:12  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 0| 7| 7| 6| 4| 0| 4| 5| 7| 7|                                            |            |
                             DAY ON TEST   | 6| 2| 3| 4| 9| 1| 4| 9| 3| 2|                                            |            |
                                           | 3| 9| 1| 5| 5| 8| 7| 4| 0| 9|                                            |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      O     |
   B6C3F1 MICE MALE                        | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|                                            |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|                                            |      A     |
    100MG/KG                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|                                            |      L     |
     MALE                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|                                            |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Interstitium, Inflammation, Chronic  |                                                                          |      2  2.0|
      Perivascular, Infiltration Cellular, |                                                                          |            |
           Lymphocyte                      |    1                                                                     |      2  1.5|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Exudate                              |             1  1  2                                                      |     22  1.5|
      Inflammation, Acute                  |    1  1  1           2     2                                             |     24  1.5|
      Mucosa, Turbinate, Hyperplasia       |                                                                          |      1  2.0|
      Mucosa, Nasolacrimal Duct,           |                                                                          |            |
          Hyperplasia                      |       1  2  1              1                                             |     24  1.6|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Acute                           |                                                                          |      3  2.3|
      Olfactory Epithelium, Metaplasia     |                                                                          |      2  2.5|
      Turbinate, Atrophy                   |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Inflammation, Acute                  |                                                                          |      1  3.0|
      Inflammation, Chronic                |                                                                          |      1  1.0|
      Inflammation, Chronic Active         |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   2        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +  +  +  +  +  +                                             |  60        |
      Cyst                                 |                      X                                                   |      5     |
      Inflammation, Acute                  |                                                                          |      2  2.0|
      Mineralization                       |                                                                          |      2  1.5|
      Nephropathy                          |       1  2           2  2  1                                             |     28  1.4|
      Capsule, Fibrosis                    |                                                                          |      1  2.0|
      Renal Tubule, Necrosis, Acute        |                   1                                                      |      6  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  A  +  +  +  +  +                                             |  54        |
      Ectopic Tissue                       |                                                                          |      1     |
      Inflammation, Acute                  |                                                                          |      2  4.0|
      Transitional Epithelium, Hyperplasia,|                                                                          |            |
           Focal                           |                         1                                                |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  86                                                               
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                             ----------              END OF REPORT             ----------                                           
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