Share This:
https://ntp.niehs.nih.gov/go/4601

TR 396 Rat Pathology Tables


                                     INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
                                                       MONOCHLOROACETIC ACID


NTP Experiment-Test: 05705-02                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 09/18/94
Route: GAVAGE                                                                                                     Time: 21:14:39




       Facility:  International Research and Development Corp.

       Chemical CAS #:  79-11-8

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05705-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 09/18/94  
Route: GAVAGE                                                                                                     Time: 21:14:39  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   CONTROL      15 MG/KG     30 MG/KG                                               
                                                   FEMALE        FEMALE       FEMALE                                                
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          70           70           70                                                  
  Scheduled Sacrifice                                 17           17           17                                                  
  Early Deaths                                                                                                                      
    Moribund                                          14           21           13                                                  
    Dead                                               2           11           13                                                  
    Dosing Accident                                                 2            1                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                37           19           25                                                  
    Moribund                                                                     1                                                  
  Animals Examined Microscopically                    53           53           53                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (53)         (52)         (52)                                                
      Inflammation, Acute, Focal                                                 1 (2%)                                             
   Intestine Large, Cecum                             (53)         (53)         (51)                                                
      Autolysis                                                     3 (6%)                                                          
      Parasite Metazoan                                             1 (2%)                                                          
   Intestine Large, Colon                             (53)         (53)         (51)                                                
      Autolysis                                                     1 (2%)                                                          
      Hyperplasia, Lymphoid                                         1 (2%)                                                          
      Parasite Metazoan                                8 (15%)      3 (6%)       6 (12%)                                            
   Intestine Large, Rectum                            (52)         (53)         (50)                                                
      Hyperplasia, Lymphoid                                                      1 (2%)                                             
      Parasite Metazoan                                2 (4%)       1 (2%)       3 (6%)                                             
      Submucosa, Inflammation, Acute, Focal                                      1 (2%)                                             
   Intestine Small, Duodenum                          (53)         (51)         (51)                                                
      Autolysis                                                     1 (2%)                                                          
   Intestine Small, Ileum                             (53)         (53)         (48)                                                
      Autolysis                                                     3 (6%)                                                          
      Congestion                                                    2 (4%)                                                          
      Edema                                                         1 (2%)                                                          
      Hyperplasia, Lymphoid                            1 (2%)       2 (4%)                                                          
      Parasite Metazoan                                             1 (2%)                                                          
   Intestine Small, Jejunum                           (53)         (52)         (49)                                                
      Autolysis                                                     3 (6%)                                                          
   Liver                                              (53)         (53)         (53)                                                
      Angiectasis                                      1 (2%)                                                                       
      Angiectasis, Focal                               1 (2%)                    1 (2%)                                             
      Basophilic Focus                                16 (30%)      6 (11%)     16 (30%)                                            
      Basophilic Focus, Multiple                      21 (40%)     17 (32%)     14 (26%)                                            
      Congestion                                       1 (2%)       2 (4%)       1 (2%)                                             
      Cytoplasmic Alteration, Focal                    6 (11%)      3 (6%)       4 (8%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    2                                                              
NTP Experiment-Test: 05705-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 09/18/94  
Route: GAVAGE                                                                                                     Time: 21:14:39  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   CONTROL      15 MG/KG     30 MG/KG                                               
                                                   FEMALE        FEMALE       FEMALE                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Degeneration, Fatty                              1 (2%)       1 (2%)                                                          
      Hemorrhage, Focal                                1 (2%)                                                                       
      Hepatodiaphragmatic Nodule                       4 (8%)       1 (2%)       3 (6%)                                             
      Inflammation, Acute, Focal                       2 (4%)                    2 (4%)                                             
      Inflammation, Granulomatous, Multifocal         21 (40%)     19 (36%)     18 (34%)                                            
      Necrosis, Acute, Coagulative, Multifocal         1 (2%)                                                                       
      Necrosis, Acute, Focal                                        2 (4%)       1 (2%)                                             
      Vacuolization Cytoplasmic, Focal                 1 (2%)       1 (2%)                                                          
      Bile Duct, Hyperplasia                           7 (13%)      1 (2%)       3 (6%)                                             
      Hepatocyte, Hypertrophy, Focal                   1 (2%)                                                                       
   Mesentery                                          (4)                       (2)                                                 
      Inflammation, Chronic, Multifocal                1 (25%)                   1 (50%)                                            
      Fat, Necrosis, Focal                             3 (75%)                   2 (100%)                                           
   Pancreas                                           (53)         (53)         (51)                                                
      Atrophy, Focal                                  19 (36%)     15 (28%)     10 (20%)                                            
      Cytoplasmic Alteration, Focal                                 1 (2%)                                                          
      Inflammation, Chronic, Focal                     1 (2%)                                                                       
      Acinus, Hyperplasia                                                        1 (2%)                                             
   Salivary Glands                                    (53)         (53)         (53)                                                
      Atrophy, Focal                                                             1 (2%)                                             
      Hemorrhage                                       1 (2%)                                                                       
      Hyperplasia, Focal                                            1 (2%)                                                          
      Infiltration Cellular, Multifocal, Lymphocyte                              2 (4%)                                             
      Inflammation, Chronic                                                      1 (2%)                                             
      Duct, Inflammation, Chronic                      5 (9%)                    2 (4%)                                             
      Duct, Inflammation, Chronic Active               8 (15%)                   7 (13%)                                            
   Stomach, Forestomach                               (51)         (52)         (53)                                                
      Inflammation, Acute                              2 (4%)       3 (6%)       1 (2%)                                             
      Inflammation, Chronic                            1 (2%)                    1 (2%)                                             
      Inflammation, Chronic Active                     2 (4%)       1 (2%)                                                          
      Ulcer                                                                      1 (2%)                                             
      Epithelium, Hyperplasia                          6 (12%)      4 (8%)       4 (8%)                                             
      Muscularis, Hypertrophy, Focal                                             1 (2%)                                             
      Submucosa, Inflammation, Acute                                             1 (2%)                                             
   Stomach, Glandular                                 (53)         (53)         (53)                                                
      Infiltration Cellular, Focal, Lymphocyte                                   1 (2%)                                             
      Inflammation, Acute                                           1 (2%)       1 (2%)                                             
      Inflammation, Chronic Active                     1 (2%)                                                                       
      Necrosis, Acute                                  1 (2%)       4 (8%)       3 (6%)                                             
      Pigmentation, Focal                                           1 (2%)                                                          
      Arteriole, Submucosa, Thrombosis                                           1 (2%)                                             
      Serosa, Inflammation, Chronic, Multifocal                                  1 (2%)                                             
      Submucosa, Inflammation, Chronic                                           1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    3                                                              
NTP Experiment-Test: 05705-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 09/18/94  
Route: GAVAGE                                                                                                     Time: 21:14:39  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   CONTROL      15 MG/KG     30 MG/KG                                               
                                                   FEMALE        FEMALE       FEMALE                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (53)         (53)         (53)                                                
      Inflammation, Chronic                           41 (77%)     31 (58%)     36 (68%)                                            
      Atrium Left, Thrombosis                          1 (2%)       2 (4%)                                                          
      Coronary Artery, Inflammation, Chronic                                     1 (2%)                                             
      Pericardium, Fibrosis, Focal                                               1 (2%)                                             
      Valve, Thrombosis                                                          1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (53)         (53)         (52)                                                
      Angiectasis, Focal                                                         1 (2%)                                             
      Congestion                                       1 (2%)       1 (2%)       2 (4%)                                             
      Ectasia                                          2 (4%)                                                                       
      Hemorrhage                                                    2 (4%)       1 (2%)                                             
      Hyperplasia, Focal                              10 (19%)      8 (15%)     12 (23%)                                            
      Hypertrophy                                      1 (2%)                                                                       
      Hypertrophy, Focal                               9 (17%)      4 (8%)       4 (8%)                                             
      Mineralization                                                1 (2%)                                                          
      Necrosis, Acute, Focal                                        1 (2%)                                                          
      Thrombosis                                                    1 (2%)                                                          
      Vacuolization Cytoplasmic, Diffuse                            2 (4%)                                                          
      Vacuolization Cytoplasmic, Focal                11 (21%)      9 (17%)      6 (12%)                                            
      Bilateral, Hyperplasia, Focal                                 1 (2%)                                                          
   Adrenal Gland, Medulla                             (52)         (52)         (53)                                                
      Hyperplasia, Focal                               4 (8%)                    4 (8%)                                             
   Islets, Pancreatic                                 (53)         (53)         (51)                                                
      Hyperplasia                                                   1 (2%)                                                          
   Parathyroid Gland                                  (43)         (43)         (42)                                                
      Congestion, Focal                                                          1 (2%)                                             
      Hyperplasia                                      1 (2%)                                                                       
   Pituitary Gland                                    (53)         (53)         (53)                                                
      Autolysis                                                                  1 (2%)                                             
      Congestion, Focal                                                          1 (2%)                                             
      Hemorrhage                                                                 2 (4%)                                             
      Pigmentation, Focal                              1 (2%)                                                                       
      Pars Distalis, Angiectasis                       6 (11%)      4 (8%)       5 (9%)                                             
      Pars Distalis, Cyst                             10 (19%)      4 (8%)       7 (13%)                                            
      Pars Distalis, Ectasia                                                     1 (2%)                                             
      Pars Distalis, Hyperplasia                       9 (17%)     12 (23%)     13 (25%)                                            
      Pars Distalis, Vacuolization Nuclear                                       1 (2%)                                             
   Thyroid Gland                                      (53)         (52)         (52)                                                
      Ultimobranchial Cyst                                          1 (2%)       1 (2%)                                             
      C-Cell, Hyperplasia                             20 (38%)      8 (15%)     16 (31%)                                            
      Follicle, Cyst                                                             1 (2%)                                             
      Follicular Cell, Hyperplasia                                               1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    4                                                              
NTP Experiment-Test: 05705-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 09/18/94  
Route: GAVAGE                                                                                                     Time: 21:14:39  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   CONTROL      15 MG/KG     30 MG/KG                                               
                                                   FEMALE        FEMALE       FEMALE                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (44)         (45)         (48)                                                
      Hyperplasia                                                   1 (2%)       1 (2%)                                             
      Hyperplasia, Squamous                                         1 (2%)                                                          
      Inflammation, Acute                              5 (11%)      8 (18%)      4 (8%)                                             
      Inflammation, Chronic                           11 (25%)      6 (13%)     12 (25%)                                            
      Inflammation, Chronic Active                     6 (14%)      1 (2%)       5 (10%)                                            
   Ovary                                              (53)         (53)         (53)                                                
      Atrophy                                                                    1 (2%)                                             
      Hemorrhage                                       1 (2%)                                                                       
      Follicle, Cyst                                   6 (11%)      2 (4%)       5 (9%)                                             
      Periovarian Tissue, Cyst                         1 (2%)                    1 (2%)                                             
   Uterus                                             (53)         (53)         (53)                                                
      Dilatation                                       2 (4%)       5 (9%)       3 (6%)                                             
      Hemorrhage                                                                 1 (2%)                                             
      Inflammation, Acute                              2 (4%)                                                                       
      Inflammation, Chronic                            1 (2%)                                                                       
      Endometrium, Fibrosis                                                      1 (2%)                                             
      Endometrium, Hyperplasia, Cystic                 1 (2%)       2 (4%)                                                          
   Vagina                                                          (1)                                                              
      Inflammation, Acute                                           1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (53)         (53)         (53)                                                
      Hyperplasia                                      1 (2%)       1 (2%)                                                          
      Hypoplasia                                       1 (2%)                                                                       
      Myelofibrosis                                    2 (4%)       3 (6%)                                                          
      Pigmentation                                     1 (2%)                                                                       
      Myeloid Cell, Hyperplasia                                     4 (8%)                                                          
   Lymph Node                                         (53)         (52)         (53)                                                
      Mediastinal, Congestion                                                    2 (4%)                                             
      Renal, Congestion                                             1 (2%)                                                          
      Renal, Hemorrhage                                             1 (2%)                                                          
   Lymph Node, Mesenteric                             (52)         (52)         (53)                                                
      Congestion                                                                 1 (2%)                                             
      Edema                                            1 (2%)                                                                       
      Hemorrhage                                                    1 (2%)                                                          
      Hyperplasia, Lymphoid                                         1 (2%)       1 (2%)                                             
      Lymphocyte, Depletion Cellular                                             1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    5                                                              
NTP Experiment-Test: 05705-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 09/18/94  
Route: GAVAGE                                                                                                     Time: 21:14:39  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   CONTROL      15 MG/KG     30 MG/KG                                               
                                                   FEMALE        FEMALE       FEMALE                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
   Spleen                                             (53)         (53)         (53)                                                
      Angiectasis                                                   1 (2%)                                                          
      Fibrosis                                         1 (2%)                    1 (2%)                                             
      Hematopoietic Cell Proliferation Granulocytic    2 (4%)       5 (9%)                                                          
      Inflammation, Focal, Granulomatous                            1 (2%)                                                          
      Necrosis, Focal                                               1 (2%)                                                          
      Pigmentation                                     3 (6%)       1 (2%)       4 (8%)                                             
      Capsule, Fibrosis, Multifocal                                              1 (2%)                                             
   Thymus                                             (51)         (51)         (44)                                                
      Autolysis                                        1 (2%)                                                                       
      Cyst                                             2 (4%)                    1 (2%)                                             
      Hemorrhage                                       1 (2%)       1 (2%)       1 (2%)                                             
      Hyperplasia, Lymphoid                                                      1 (2%)                                             
      Medulla, Hyperplasia, Focal                                                1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (53)         (53)         (51)                                                
      Galactocele                                      5 (9%)                    5 (10%)                                            
      Hyperplasia                                     23 (43%)                  22 (43%)                                            
      Hyperplasia, Cystic                                           1 (2%)                                                          
      Inflammation, Acute                                           1 (2%)       1 (2%)                                             
      Inflammation, Chronic Active, Multifocal                                   1 (2%)                                             
      Duct, Ectasia                                   23 (43%)     11 (21%)      2 (4%)                                             
   Skin                                               (53)         (52)         (52)                                                
      Face, Inflammation, Acute                                     1 (2%)                                                          
      Face, Inflammation, Chronic Active, Focal                                  1 (2%)                                             
      Subcutaneous Tissue, Hemorrhage                  1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (53)         (53)         (53)                                                
      Hyperostosis                                                               1 (2%)                                             
      Osteopetrosis                                    1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (53)         (53)         (53)                                                
      Congestion                                                                 2 (4%)                                             
      Hemorrhage, Focal                                             1 (2%)                                                          
      Hydrocephalus                                    1 (2%)                                                                       
      Inflammation, Acute, Focal                                    1 (2%)                                                          
      Inflammation, Chronic, Focal                                  1 (2%)                                                          
      Cerebellum, Cyst                                                           1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    6                                                              
NTP Experiment-Test: 05705-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 09/18/94  
Route: GAVAGE                                                                                                     Time: 21:14:39  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   CONTROL      15 MG/KG     30 MG/KG                                               
                                                   FEMALE        FEMALE       FEMALE                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
NERVOUS SYSTEM - CONT                                                                                                               
      Third Ventricle, Dilatation                      1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (53)         (53)         (53)                                                
      Congestion                                       1 (2%)       6 (11%)     13 (25%)                                            
      Fibrosis, Focal                                               1 (2%)                                                          
      Hemorrhage                                       1 (2%)       1 (2%)       1 (2%)                                             
      Inflammation, Chronic                            1 (2%)       1 (2%)       3 (6%)                                             
      Inflammation, Granulomatous, Multifocal                                    1 (2%)                                             
      Alveolar Epithelium, Hyperplasia, Focal                       1 (2%)       2 (4%)                                             
      Alveolus, Infiltration Cellular, Histiocyte      3 (6%)       3 (6%)       2 (4%)                                             
      Interstitium, Infiltration Cellular,                                                                                          
          Multifocal                                   1 (2%)                                                                       
      Perivascular, Inflammation, Chronic             14 (26%)                  12 (23%)                                            
   Nose                                               (52)         (53)         (48)                                                
      Autolysis                                                     4 (8%)                                                          
      Foreign Body                                                  1 (2%)       1 (2%)                                             
      Fungus                                           5 (10%)      1 (2%)       1 (2%)                                             
      Hemorrhage                                                    3 (6%)                                                          
      Inflammation, Chronic, Focal                     1 (2%)                                                                       
      Mucosa, Inflammation, Acute                                   6 (11%)      5 (10%)                                            
      Mucosa, Inflammation, Chronic Active             5 (10%)      2 (4%)       1 (2%)                                             
      Nasolacrimal Duct, Cyst                                       1 (2%)       1 (2%)                                             
      Nasolacrimal Duct, Inflammation, Acute           4 (8%)       1 (2%)       6 (13%)                                            
      Nasolacrimal Duct, Inflammation, Chronic                                   4 (8%)                                             
      Nasolacrimal Duct, Inflammation, Chronic                                                                                      
          Active                                       1 (2%)       1 (2%)       3 (6%)                                             
      Sinus, Inflammation, Acute                                    1 (2%)       1 (2%)                                             
      Vein, Thrombosis                                              1 (2%)                                                          
   Trachea                                            (53)         (53)         (53)                                                
      Inflammation, Chronic                                                      2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (3)          (4)          (2)                                                 
      Bilateral, Lens, Cataract                                     1 (25%)                                                         
      Lens, Cataract                                   2 (67%)      2 (50%)      2 (100%)                                           
      Retina, Degeneration                             3 (100%)     1 (25%)      2 (100%)                                           
      Sclera, Mineralization, Focal                                              1 (50%)                                            
   Harderian Gland                                                              (1)                                                 
      Inflammation, Chronic                                                      1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    7                                                              
NTP Experiment-Test: 05705-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 09/18/94  
Route: GAVAGE                                                                                                     Time: 21:14:39  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS FEMALE                   CONTROL      15 MG/KG     30 MG/KG                                               
                                                   FEMALE        FEMALE       FEMALE                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (53)         (53)         (52)                                                
      Autolysis                                                     7 (13%)      1 (2%)                                             
      Congestion                                                    3 (6%)       1 (2%)                                             
      Hemorrhage                                                    1 (2%)       1 (2%)                                             
      Inflammation, Multifocal, Suppurative                                      1 (2%)                                             
      Mineralization, Focal                                         2 (4%)                                                          
      Mineralization, Multifocal                       9 (17%)      2 (4%)      15 (29%)                                            
      Nephropathy                                     46 (87%)     38 (72%)     35 (67%)                                            
      Cortex, Renal Tubule, Necrosis                                             1 (2%)                                             
      Cortex, Renal Tubule, Necrosis, Focal                         1 (2%)                                                          
      Renal Tubule, Epithelium, Pigmentation           3 (6%)       4 (8%)       2 (4%)                                             
   Urinary Bladder                                    (52)         (52)         (49)                                                
      Calculus Micro Observation Only, Multifocal      1 (2%)                                                                       
      Hemorrhage, Focal                                                          1 (2%)                                             
      Hyperplasia, Papillary                           1 (2%)                                                                       
      Infiltration Cellular, Lymphocyte                             1 (2%)                                                          
      Transitional Epithelium, Hyperplasia                          1 (2%)                                                          
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    8                                                              
NTP Experiment-Test: 05705-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 09/18/94  
Route: GAVAGE                                                                                                     Time: 21:14:39  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     CONTROL      15 MG/KG     30 MG/KG                                               
                                                   MALE          MALE         MALE                                                  
____________________________________________________________________________________________________________________________________
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially In Study                          70           70           70                                                  
  Scheduled Sacrifice                                 17           17           17                                                  
  Early Deaths                                                                                                                      
    Dead                                               8           11           20                                                  
    Moribund                                          17           21           15                                                  
    Accident                                           1                                                                            
    Dosing Accident                                                              2                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                27           21           16                                                  
  Animals Examined Microscopically                    53           53           53                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Esophagus                                          (53)         (53)         (53)                                                
      Wall, Inflammation, Chronic                                                1 (2%)                                             
   Intestine Large, Cecum                             (52)         (52)         (53)                                                
      Autolysis                                                     1 (2%)                                                          
      Inflammation, Acute                              2 (4%)       1 (2%)       1 (2%)                                             
      Parasite Metazoan                                1 (2%)                                                                       
   Intestine Large, Colon                             (53)         (53)         (53)                                                
      Hyperplasia, Lymphoid                                         1 (2%)                                                          
      Infiltration Cellular, Lymphocyte                1 (2%)                                                                       
      Parasite Metazoan                               11 (21%)      6 (11%)     12 (23%)                                            
   Intestine Large, Rectum                            (53)         (52)         (52)                                                
      Inflammation, Acute                              1 (2%)                                                                       
      Parasite Metazoan                                5 (9%)                    2 (4%)                                             
   Intestine Small                                    (53)         (53)         (53)                                                
      Perivascular, Inflammation, Chronic                                        1 (2%)                                             
      Serosa, Inflammation, Chronic                                              1 (2%)                                             
   Intestine Small, Duodenum                          (52)         (53)         (53)                                                
      Autolysis                                        1 (2%)                                                                       
      Inflammation, Chronic                                                      1 (2%)                                             
      Necrosis, Acute, Focal                                                     1 (2%)                                             
   Intestine Small, Ileum                             (53)         (52)         (51)                                                
      Autolysis                                        1 (2%)       3 (6%)       1 (2%)                                             
      Parasite Metazoan                                                          1 (2%)                                             
   Intestine Small, Jejunum                           (51)         (52)         (52)                                                
      Autolysis                                        1 (2%)       2 (4%)                                                          
   Liver                                              (53)         (53)         (53)                                                
      Angiectasis                                      1 (2%)                                                                       
      Angiectasis, Focal                               1 (2%)       1 (2%)                                                          
      Basophilic Focus                                 9 (17%)      1 (2%)       5 (9%)                                             
      Basophilic Focus, Multiple                       3 (6%)      10 (19%)      3 (6%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page    9                                                              
NTP Experiment-Test: 05705-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 09/18/94  
Route: GAVAGE                                                                                                     Time: 21:14:39  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     CONTROL      15 MG/KG     30 MG/KG                                               
                                                   MALE          MALE         MALE                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
      Clear Cell Focus                                              1 (2%)       1 (2%)                                             
      Congestion                                       1 (2%)       2 (4%)       1 (2%)                                             
      Cytoplasmic Alteration, Focal                    9 (17%)      3 (6%)       4 (8%)                                             
      Cytoplasmic Alteration, Multifocal               2 (4%)                                                                       
      Fatty Change, Diffuse                            1 (2%)                                                                       
      Fatty Change, Multifocal                         1 (2%)                                                                       
      Hepatodiaphragmatic Nodule                                    2 (4%)                                                          
      Hyperplasia, Focal                                            1 (2%)                                                          
      Inflammation, Acute, Multifocal                                            1 (2%)                                             
      Inflammation, Chronic                                         3 (6%)                                                          
      Inflammation, Granulomatous, Multifocal          1 (2%)       3 (6%)                                                          
      Necrosis, Acute, Focal                           2 (4%)       1 (2%)       3 (6%)                                             
      Pigmentation, Diffuse                            1 (2%)                                                                       
      Thrombosis                                       1 (2%)       1 (2%)                                                          
      Vacuolization Cytoplasmic, Focal                 1 (2%)       1 (2%)       2 (4%)                                             
      Artery, Thrombosis                               1 (2%)                                                                       
      Bile Duct, Hyperplasia                          20 (38%)     11 (21%)     17 (32%)                                            
      Centrilobular, Fatty Change                                   1 (2%)       1 (2%)                                             
      Centrilobular, Vacuolization Cytoplasmic                      1 (2%)                                                          
      Hepatocyte, Degeneration, Cystic, Focal          5 (9%)       3 (6%)       2 (4%)                                             
      Hepatocyte, Hypertrophy, Focal                                             1 (2%)                                             
   Mesentery                                          (2)          (1)          (2)                                                 
      Inflammation, Chronic                                                      1 (50%)                                            
      Fat, Necrosis, Chronic, Multifocal               1 (50%)                                                                      
      Fat, Necrosis, Focal                                          1 (100%)                                                        
   Pancreas                                           (52)         (53)         (52)                                                
      Atrophy, Focal                                  16 (31%)     20 (38%)     14 (27%)                                            
      Congestion, Focal                                             1 (2%)                                                          
      Cytoplasmic Alteration, Focal                    1 (2%)                                                                       
      Hyperplasia, Focal                                            1 (2%)                                                          
      Infiltration Cellular, Focal, Lymphocyte                                   1 (2%)                                             
      Inflammation, Chronic                                         1 (2%)                                                          
      Artery, Inflammation, Chronic                    1 (2%)                                                                       
      Artery, Mineralization                                        1 (2%)                                                          
      Duct, Ectasia, Focal                                          1 (2%)       1 (2%)                                             
      Perivascular, Inflammation, Chronic                                        2 (4%)                                             
   Salivary Glands                                    (52)         (53)         (53)                                                
      Atrophy, Diffuse                                 1 (2%)                                                                       
      Inflammation, Acute, Focal                                    3 (6%)                                                          
      Inflammation, Chronic                                         1 (2%)       2 (4%)                                             
      Duct, Ectasia, Focal                             1 (2%)                                                                       
      Duct, Inflammation, Acute                                     1 (2%)                                                          
      Duct, Inflammation, Chronic Active                                         1 (2%)                                             
      Periductular, Inflammation, Chronic                                        1 (2%)                                             
   Stomach                                            (53)         (52)         (53)                                                
      Perivascular, Inflammation, Chronic                                        1 (2%)                                             
      Serosa, Inflammation, Chronic                                              1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   10                                                              
NTP Experiment-Test: 05705-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 09/18/94  
Route: GAVAGE                                                                                                     Time: 21:14:39  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     CONTROL      15 MG/KG     30 MG/KG                                               
                                                   MALE          MALE         MALE                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ALIMENTARY SYSTEM - CONT                                                                                                            
   Stomach, Forestomach                               (53)         (52)         (53)                                                
      Hyperplasia                                      1 (2%)                                                                       
      Inflammation, Acute                              3 (6%)       4 (8%)       3 (6%)                                             
      Inflammation, Chronic                            2 (4%)                    1 (2%)                                             
      Inflammation, Chronic Active                                  1 (2%)       1 (2%)                                             
      Mineralization                                                1 (2%)       2 (4%)                                             
      Necrosis, Focal                                  1 (2%)                                                                       
      Epithelium, Hyperplasia                          2 (4%)       6 (12%)      2 (4%)                                             
      Serosa, Inflammation, Chronic                                              1 (2%)                                             
   Stomach, Glandular                                 (52)         (52)         (53)                                                
      Hemorrhage, Focal                                                          1 (2%)                                             
      Infiltration Cellular, Focal, Lymphocyte                                   4 (8%)                                             
      Infiltration Cellular, Lymphocyte                             4 (8%)                                                          
      Inflammation, Acute                              1 (2%)       1 (2%)                                                          
      Inflammation, Chronic                            1 (2%)       2 (4%)       1 (2%)                                             
      Inflammation, Chronic Active                                  1 (2%)                                                          
      Mineralization                                   1 (2%)       4 (8%)       3 (6%)                                             
      Necrosis, Focal                                  2 (4%)       5 (10%)      2 (4%)                                             
   Tongue                                                                       (3)                                                 
      Epithelium, Hyperplasia, Focal                                             2 (67%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Blood Vessel                                       (53)         (53)         (52)                                                
      Inflammation, Acute                                           1 (2%)                                                          
      Aorta, Mineralization                                         1 (2%)       2 (4%)                                             
   Heart                                              (52)         (53)         (53)                                                
      Fibrosis, Focal                                  2 (4%)                                                                       
      Inflammation, Chronic                           48 (92%)     45 (85%)     46 (87%)                                            
      Mineralization                                   2 (4%)       3 (6%)       2 (4%)                                             
      Artery, Mineralization, Multifocal               1 (2%)                                                                       
      Atrium Left, Thrombosis                          5 (10%)      4 (8%)       3 (6%)                                             
      Perivascular, Inflammation, Chronic                                        1 (2%)                                             
      Valve, Thrombosis                                2 (4%)       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (52)         (51)         (53)                                                
      Cyst                                                          1 (2%)                                                          
      Hemorrhage, Focal                                                          1 (2%)                                             
      Hyperplasia                                                   1 (2%)                                                          
      Hyperplasia, Focal                               9 (17%)      8 (16%)     12 (23%)                                            
      Hypertrophy, Focal                               5 (10%)      5 (10%)      3 (6%)                                             
      Necrosis, Focal                                  1 (2%)       2 (4%)                                                          
      Vacuolization Cytoplasmic, Diffuse               2 (4%)                                                                       
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   11                                                              
NTP Experiment-Test: 05705-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 09/18/94  
Route: GAVAGE                                                                                                     Time: 21:14:39  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     CONTROL      15 MG/KG     30 MG/KG                                               
                                                   MALE          MALE         MALE                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - CONT                                                                                                             
      Vacuolization Cytoplasmic, Focal                 7 (13%)     10 (20%)      5 (9%)                                             
   Adrenal Gland, Medulla                             (51)         (50)         (53)                                                
      Hyperplasia, Focal                              10 (20%)      6 (12%)      7 (13%)                                            
      Mineralization, Focal                                                      1 (2%)                                             
      Thrombosis                                                    1 (2%)       1 (2%)                                             
      Bilateral, Hyperplasia, Focal                                 1 (2%)                                                          
   Islets, Pancreatic                                 (52)         (53)         (52)                                                
      Hyperplasia, Focal                               1 (2%)                                                                       
   Parathyroid Gland                                  (48)         (47)         (37)                                                
      Hyperplasia                                                   3 (6%)       4 (11%)                                            
      Hyperplasia, Focal                                            1 (2%)                                                          
   Pituitary Gland                                    (53)         (52)         (53)                                                
      Hemorrhage                                                    1 (2%)                                                          
      Pars Distalis, Angiectasis                       1 (2%)       3 (6%)       1 (2%)                                             
      Pars Distalis, Cyst                              2 (4%)       2 (4%)       1 (2%)                                             
      Pars Distalis, Hyperplasia                       8 (15%)      7 (13%)      6 (11%)                                            
      Pars Intermedia, Hyperplasia, Focal                           1 (2%)                                                          
      Pars Nervosa, Hyperplasia                        1 (2%)                                                                       
   Thyroid Gland                                      (53)         (53)         (53)                                                
      Ultimobranchial Cyst                             1 (2%)                                                                       
      C-Cell, Hyperplasia                             11 (21%)      6 (11%)      4 (8%)                                             
      Follicular Cell, Hyperplasia                     3 (6%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (52)         (50)         (52)                                                
      Duct, Epithelium, Degeneration                   1 (2%)                                                                       
   Penis                                                                        (1)                                                 
      Inflammation, Acute                                                        1 (100%)                                           
   Preputial Gland                                    (51)         (52)         (52)                                                
      Cyst                                                          1 (2%)                                                          
      Ectasia                                                                    1 (2%)                                             
      Hyperplasia                                                   2 (4%)                                                          
      Inflammation, Acute                             10 (20%)      7 (13%)      8 (15%)                                            
      Inflammation, Chronic                           18 (35%)     28 (54%)     16 (31%)                                            
      Inflammation, Chronic Active                                  1 (2%)                                                          
      Duct, Hyperplasia, Squamous                      1 (2%)                                                                       
   Prostate                                           (48)         (52)         (53)                                                
      Hyperplasia, Focal                               4 (8%)       4 (8%)       1 (2%)                                             
      Inflammation, Acute                              6 (13%)                   4 (8%)                                             
      Inflammation, Chronic                            1 (2%)       5 (10%)      2 (4%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   12                                                              
NTP Experiment-Test: 05705-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 09/18/94  
Route: GAVAGE                                                                                                     Time: 21:14:39  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     CONTROL      15 MG/KG     30 MG/KG                                               
                                                   MALE          MALE         MALE                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
GENITAL SYSTEM - CONT                                                                                                               
      Inflammation, Chronic Active                                  2 (4%)                                                          
      Mineralization                                                             2 (4%)                                             
      Epithelium, Degeneration, Focal                  1 (2%)                                                                       
   Testes                                             (53)         (51)         (52)                                                
      Atrophy                                          6 (11%)      6 (12%)      1 (2%)                                             
      Hemorrhage                                                                 1 (2%)                                             
      Infarct, Diffuse                                                           1 (2%)                                             
      Mineralization, Focal                            1 (2%)                                                                       
      Bilateral, Interstitial Cell, Hyperplasia        1 (2%)       1 (2%)                                                          
      Interstitial Cell, Hyperplasia                   6 (11%)      6 (12%)      6 (12%)                                            
      Seminiferous Tubule, Degeneration                1 (2%)                    1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (53)         (52)         (52)                                                
      Hyperplasia                                      2 (4%)       2 (4%)                                                          
      Hyperplasia, Megakaryocyte                       1 (2%)                                                                       
      Hypoplasia                                       2 (4%)                    2 (4%)                                             
      Myelofibrosis                                                 2 (4%)       2 (4%)                                             
      Myeloid Cell, Hyperplasia                        2 (4%)       3 (6%)       1 (2%)                                             
   Lymph Node                                         (53)         (52)         (53)                                                
      Axillary, Congestion                             1 (2%)                                                                       
      Axillary, Hyperplasia                                         1 (2%)                                                          
      Iliac, Hyperplasia, Plasma Cell                  1 (2%)                                                                       
      Iliac, Inflammation, Focal, Granulomatous        1 (2%)                                                                       
      Inguinal, Infiltration Cellular, Plasma Cell                  1 (2%)                                                          
      Inguinal, Inflammation, Acute, Multifocal        1 (2%)                                                                       
      Mediastinal, Congestion                          5 (9%)                    2 (4%)                                             
      Mediastinal, Hemorrhage                                       1 (2%)                                                          
      Mediastinal, Hyperplasia                         1 (2%)       1 (2%)                                                          
      Pancreatic, Congestion                           1 (2%)                                                                       
      Pancreatic, Fibrosis, Focal                                                1 (2%)                                             
      Pancreatic, Inflammation, Chronic                             1 (2%)                                                          
      Renal, Hemorrhage                                             1 (2%)                                                          
   Lymph Node, Mesenteric                             (53)         (52)         (53)                                                
      Congestion                                       1 (2%)       1 (2%)       1 (2%)                                             
      Hemorrhage                                                    2 (4%)                                                          
      Hyperplasia                                      1 (2%)       1 (2%)                                                          
      Hyperplasia, Re Cell                                                       1 (2%)                                             
      Necrosis, Focal                                               1 (2%)                                                          
   Spleen                                             (53)         (53)         (53)                                                
      Congestion                                                                 2 (4%)                                             
      Fibrosis                                         1 (2%)       5 (9%)       1 (2%)                                             
      Fibrosis, Focal                                  1 (2%)                                                                       
      Hematopoietic Cell Proliferation                              2 (4%)                                                          
      Hematopoietic Cell Proliferation Granulocytic    2 (4%)       1 (2%)       1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   13                                                              
NTP Experiment-Test: 05705-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 09/18/94  
Route: GAVAGE                                                                                                     Time: 21:14:39  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     CONTROL      15 MG/KG     30 MG/KG                                               
                                                   MALE          MALE         MALE                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
HEMATOPOIETIC SYSTEM - CONT                                                                                                         
      Hemorrhage, Multifocal                           1 (2%)                                                                       
      Necrosis, Focal                                               1 (2%)                                                          
      Pigmentation, Diffuse                            1 (2%)                                                                       
      Capsule, Fibrosis, Focal                         2 (4%)                                                                       
   Thymus                                             (47)         (48)         (50)                                                
      Congestion                                                                 2 (4%)                                             
      Cyst, Multiple                                   1 (2%)                    3 (6%)                                             
      Ectasia                                                       1 (2%)                                                          
      Hemorrhage                                       2 (4%)                                                                       
      Hyperplasia                                                   1 (2%)       2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (53)         (52)         (53)                                                
      Fibrosis                                                      1 (2%)                                                          
      Hyperplasia                                      2 (4%)       6 (12%)      9 (17%)                                            
      Hyperplasia, Cystic                              1 (2%)                    2 (4%)                                             
      Mineralization                                                1 (2%)                                                          
      Pigmentation                                                  1 (2%)       1 (2%)                                             
      Duct, Ectasia                                    2 (4%)       8 (15%)                                                         
   Skin                                               (53)         (51)         (53)                                                
      Hemorrhage                                                    1 (2%)                                                          
      Inflammation, Acute                              1 (2%)       1 (2%)                                                          
      Inflammation, Chronic, Focal                                               1 (2%)                                             
      Inflammation, Chronic Active                                  1 (2%)                                                          
      Face, Inflammation, Acute, Focal                                           1 (2%)                                             
      Subcutaneous Tissue, Edema                                    1 (2%)                                                          
      Subcutaneous Tissue, Inflammation, Acute         1 (2%)                                                                       
      Subcutaneous Tissue, Necrosis                    1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (53)         (52)         (52)                                                
      Fibrous Osteodystrophy                           1 (2%)       4 (8%)       3 (6%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (53)         (53)         (53)                                                
      Congestion                                       1 (2%)                                                                       
      Hemorrhage, Focal                                1 (2%)       1 (2%)       1 (2%)                                             
      Hydrocephalus                                                              1 (2%)                                             
      Cerebellum, Pigmentation, Focal                                            1 (2%)                                             
      Meninges, Vein, Cerebrum, Thrombosis                          1 (2%)                                                          
      Thalamus, Inflammation, Chronic, Focal                                     1 (2%)                                             
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   14                                                              
NTP Experiment-Test: 05705-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 09/18/94  
Route: GAVAGE                                                                                                     Time: 21:14:39  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     CONTROL      15 MG/KG     30 MG/KG                                               
                                                   MALE          MALE         MALE                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (53)         (53)         (53)                                                
      Congestion                                       2 (4%)       6 (11%)     10 (19%)                                            
      Fibrosis, Multifocal                                          2 (4%)                                                          
      Hemorrhage, Focal                                             2 (4%)                                                          
      Inflammation, Acute, Focal                       2 (4%)                                                                       
      Inflammation, Chronic                            3 (6%)       4 (8%)       4 (8%)                                             
      Inflammation, Focal, Granulomatous               4 (8%)                                                                       
      Mineralization, Focal                            1 (2%)                                                                       
      Alveolar Epithelium, Hyperplasia                              1 (2%)                                                          
      Alveolar Epithelium, Hyperplasia, Focal                       1 (2%)                                                          
      Alveolus, Infiltration Cellular, Histiocyte      2 (4%)       4 (8%)       1 (2%)                                             
      Alveolus, Pigmentation                                        1 (2%)                                                          
      Artery, Media, Hypertrophy                                    1 (2%)                                                          
      Bronchiole, Inflammation, Chronic Active,                                                                                     
           Multifocal                                                            1 (2%)                                             
      Peribronchial, Infiltration Cellular,                                                                                         
          Lymphocyte                                                             1 (2%)                                             
      Perivascular, Inflammation, Chronic              4 (8%)       2 (4%)       2 (4%)                                             
      Pleura, Fibrosis, Focal                                                    1 (2%)                                             
      Pleura, Infiltration Cellular, Focal,                                                                                         
          Histiocyte                                                             1 (2%)                                             
      Subpleura, Inflammation, Chronic                                           2 (4%)                                             
   Nose                                               (52)         (53)         (53)                                                
      Autolysis                                                     2 (4%)       3 (6%)                                             
      Congestion                                                                 2 (4%)                                             
      Cyst                                             3 (6%)                                                                       
      Foreign Body                                                  3 (6%)                                                          
      Fungus                                           8 (15%)      8 (15%)      5 (9%)                                             
      Metaplasia, Squamous                                                       6 (11%)                                            
      Mucosa, Concretion, Focal                        1 (2%)                                                                       
      Mucosa, Inflammation, Acute                      7 (13%)      4 (8%)       9 (17%)                                            
      Mucosa, Inflammation, Chronic                                 3 (6%)                                                          
      Mucosa, Inflammation, Chronic Active             9 (17%)      8 (15%)     15 (28%)                                            
      Nasolacrimal Duct, Inflammation, Acute           3 (6%)       1 (2%)       1 (2%)                                             
      Nasolacrimal Duct, Inflammation, Chronic         1 (2%)                    2 (4%)                                             
      Respiratory Epithelium, Hyperplasia              2 (4%)                                                                       
      Respiratory Epithelium, Hyperplasia,                                                                                          
          Papillary                                                 1 (2%)                                                          
      Vomeronasal Organ, Inflammation, Acute                                     1 (2%)                                             
   Trachea                                            (53)         (53)         (53)                                                
      Inflammation, Chronic                            2 (4%)                    2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   15                                                              
NTP Experiment-Test: 05705-02         INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)               Report: PEIRPT03
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 09/18/94  
Route: GAVAGE                                                                                                     Time: 21:14:39  
____________________________________________________________________________________________________________________________________
         FISCHER 344 RATS MALE                     CONTROL      15 MG/KG     30 MG/KG                                               
                                                   MALE          MALE         MALE                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Eye                                                (4)          (3)          (3)                                                 
      Bilateral, Lens, Cataract                                     1 (33%)      1 (33%)                                            
      Lens, Cataract                                   2 (50%)      1 (33%)      2 (67%)                                            
      Retina, Degeneration                             1 (25%)                   2 (67%)                                            
      Sclera, Mineralization, Focal                    3 (75%)      3 (100%)     1 (33%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (53)         (53)         (53)                                                
      Autolysis                                                     6 (11%)                                                         
      Calculus Micro Observation Only                  1 (2%)                                                                       
      Congestion                                                    1 (2%)       1 (2%)                                             
      Mineralization, Multifocal                       1 (2%)                                                                       
      Nephropathy                                     53 (100%)    51 (96%)     48 (91%)                                            
      Cortex, Cyst                                     1 (2%)       2 (4%)                                                          
      Medulla, Inflammation, Multifocal                1 (2%)                                                                       
      Pelvis, Calculus Gross Observation               1 (2%)                                                                       
      Pelvis, Inflammation, Acute                      2 (4%)       1 (2%)                                                          
      Pelvis, Transitional Epithelium, Hyperplasia     2 (4%)       3 (6%)       2 (4%)                                             
      Renal Tubule, Epithelium, Pigmentation           3 (6%)       1 (2%)       1 (2%)                                             
   Urinary Bladder                                    (51)         (52)         (53)                                                
      Hemorrhage                                                    1 (2%)                                                          
      Inflammation, Acute                              2 (4%)                    1 (2%)                                             
      Transitional Epithelium, Hyperplasia                          1 (2%)                                                          
      Transitional Epithelium, Hyperplasia, Focal,                                                                                  
           Papillary                                                             1 (2%)                                             
                                                                                                                                    
a  Number of animals examined microscopically at site and number of animals with lesion                                             
                                                             Page   16                                                              
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------