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TR 396 Rat Pathology Tables


                              INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)
                                                       MONOCHLOROACETIC ACID


NTP Experiment-Test: 05705-02                                                                                     Report: PEIRPT05
Study Type: CHRONIC                                                                                               Date: 09/18/94
Route: GAVAGE                                                                                                     Time: 21:14:43




       Facility:  International Research and Development Corp.

       Chemical CAS #:  79-11-8

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All
































a  Number of animals examined microscopically at site and number of animals with lesion

                                                             Page   1

NTP Experiment-Test: 05705-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 09/18/94  
Route: GAVAGE                                                                                                     Time: 21:14:43  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      15 MG/KG     30 MG/KG                                               
                                                   FEMALE        FEMALE       FEMALE                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          70           70           70                                                  
  Scheduled Sacrifice                                 17           17           17                                                  
  Early Deaths                                                                                                                      
    Moribund                                          14           21           13                                                  
    Dead                                               2           11           13                                                  
    Dosing Accident                                                 2            1                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                37           19           25                                                  
    Moribund                                                                     1                                                  
  Animals Examined Microscopically                    53           53           53                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Colon                             (53)         (53)         (51)                                                
   Intestine Small, Ileum                             (53)         (53)         (48)                                                
   Liver                                              (53)         (53)         (53)                                                
      Neoplastic Nodule                                1 (2%)                                                                       
   Mesentery                                          (4)                       (2)                                                 
   Pancreas                                           (53)         (53)         (51)                                                
   Salivary Glands                                    (53)         (53)         (53)                                                
   Stomach, Forestomach                               (51)         (52)         (53)                                                
   Stomach, Glandular                                 (53)         (53)         (53)                                                
   Tongue                                             (1)                       (3)                                                 
      Squamous Cell Papilloma                          1 (100%)                  1 (33%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (53)         (53)         (53)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (53)         (53)         (52)                                                
      Adenoma                                                                    1 (2%)                                             
   Adrenal Gland, Medulla                             (52)         (52)         (53)                                                
      Pheochromocytoma Benign                          2 (4%)                                                                       
   Islets, Pancreatic                                 (53)         (53)         (51)                                                
      Carcinoma                                                                  1 (2%)                                             
   Pituitary Gland                                    (53)         (53)         (53)                                                
      Pars Distalis, Adenoma                          26 (49%)     19 (36%)     17 (32%)                                            
      Pars Distalis, Carcinoma                         2 (4%)       2 (4%)                                                          
                                                             Page   2                                                               
NTP Experiment-Test: 05705-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 09/18/94  
Route: GAVAGE                                                                                                     Time: 21:14:43  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      15 MG/KG     30 MG/KG                                               
                                                   FEMALE        FEMALE       FEMALE                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
ENDOCRINE SYSTEM - cont                                                                                                             
   Thyroid Gland                                      (53)         (52)         (52)                                                
      Bilateral, C-Cell, Adenoma                       1 (2%)                                                                       
      C-Cell, Adenoma                                  5 (9%)       3 (6%)       3 (6%)                                             
      C-Cell, Carcinoma                                2 (4%)                    2 (4%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Clitoral Gland                                     (44)         (45)         (48)                                                
      Carcinoma                                                     1 (2%)                                                          
      Sarcoma                                                                    1 (2%)                                             
   Ovary                                              (53)         (53)         (53)                                                
      Adenoma                                          1 (2%)                                                                       
      Granulosa Cell Tumor Malignant                                1 (2%)                                                          
      Granulosa Cell Tumor Benign                      1 (2%)                                                                       
   Uterus                                             (53)         (53)         (53)                                                
      Sarcoma Stromal                                  1 (2%)                                                                       
      Endometrium, Polyp Stromal                       1 (2%)       7 (13%)      9 (17%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (53)         (53)         (53)                                                
   Lymph Node                                         (53)         (52)         (53)                                                
      Mediastinal, Sarcoma                             1 (2%)                                                                       
   Lymph Node, Mesenteric                             (52)         (52)         (53)                                                
   Spleen                                             (53)         (53)         (53)                                                
   Thymus                                             (51)         (51)         (44)                                                
      Sarcoma                                          1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (53)         (53)         (51)                                                
      Carcinoma                                        2 (4%)       3 (6%)       2 (4%)                                             
      Fibroadenoma                                    26 (49%)     23 (43%)     21 (41%)                                            
      Fibroadenoma, Multiple                           1 (2%)                    1 (2%)                                             
   Skin                                               (53)         (52)         (52)                                                
      Carcinoma                                                     1 (2%)                                                          
      Keratoacanthoma                                                            1 (2%)                                             
      Subcutaneous Tissue, Fibroma                     1 (2%)       1 (2%)       1 (2%)                                             
      Subcutaneous Tissue, Fibrosarcoma                1 (2%)       1 (2%)                                                          
                                                             Page   3                                                               
NTP Experiment-Test: 05705-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 09/18/94  
Route: GAVAGE                                                                                                     Time: 21:14:43  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      15 MG/KG     30 MG/KG                                               
                                                   FEMALE        FEMALE       FEMALE                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   None                                                                                                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (53)         (53)         (53)                                                
      Astrocytoma Malignant                            2 (4%)       1 (2%)                                                          
      Carcinoma, Early Invasion, Metastatic,                                                                                        
          Pituitary Gland                              1 (2%)       1 (2%)                                                          
   Spinal Cord                                        (1)                                                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (53)         (53)         (53)                                                
   Nose                                               (52)         (53)         (48)                                                
   Trachea                                            (53)         (53)         (53)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Zymbal's Gland                                     (1)          (1)                                                              
      Carcinoma                                        1 (100%)     1 (100%)                                                        
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (53)         (53)         (52)                                                
      Hemangiosarcoma                                               1 (2%)                                                          
   Urinary Bladder                                    (52)         (52)         (49)                                                
      Transitional Epithelium, Carcinoma               1 (2%)                                                                       
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(53)        *(53)        *(53)                                                
      Leukemia Mononuclear                            16 (30%)     14 (26%)     13 (25%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   4                                                               
NTP Experiment-Test: 05705-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 09/18/94  
Route: GAVAGE                                                                                                     Time: 21:14:43  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS FEMALE                   CONTROL      15 MG/KG     30 MG/KG                                               
                                                   FEMALE        FEMALE       FEMALE                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            50          45          39                                                   
     Total Primary Neoplasms                           97          79          74                                                   
                                                                                                                                    
   Total Animals with Benign Neoplasms                 43          34          36                                                   
     Total Benign Neoplasms                            67          53          55                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms              26          24          17                                                   
     Total Malignant Neoplasms                         30          26          19                                                   
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              1           1                                                               
     Total Metastatic Neoplasm                          1           1                                                               
                                                                                                                                    
   Total Animals with Malignant Neoplasms                                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page   5                                                               
NTP Experiment-Test: 05705-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 09/18/94  
Route: GAVAGE                                                                                                     Time: 21:14:43  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      15 MG/KG     30 MG/KG                                               
                                                   MALE          MALE         MALE                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
DISPOSITION SUMMARY                                                                                                                 
  Animals Initially in Study                          70           70           70                                                  
  Scheduled Sacrifice                                 17           17           17                                                  
  Early Deaths                                                                                                                      
    Dead                                               8           11           20                                                  
    Moribund                                          17           21           15                                                  
    Accident                                           1                                                                            
    Dosing Accident                                                              2                                                  
  Survivors                                                                                                                         
    Terminal Sacrifice                                27           21           16                                                  
  Animals Examined Microscopically                    53           53           53                                                  
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ALIMENTARY SYSTEM                                                                                                                  
                                                                                                                                    
   Intestine Large, Cecum                             (52)         (52)         (53)                                                
   Intestine Large, Colon                             (53)         (53)         (53)                                                
   Intestine Small, Ileum                             (53)         (52)         (51)                                                
      Carcinoma                                                                  1 (2%)                                             
   Intestine Small, Jejunum                           (51)         (52)         (52)                                                
      Carcinoma                                                     1 (2%)                                                          
      Sarcoma                                                                    1 (2%)                                             
   Liver                                              (53)         (53)         (53)                                                
      Hepatocellular Carcinoma                                      1 (2%)                                                          
      Neoplastic Nodule                                1 (2%)                    1 (2%)                                             
   Mesentery                                          (2)          (1)          (2)                                                 
   Pancreas                                           (52)         (53)         (52)                                                
      Adenoma                                          1 (2%)       1 (2%)                                                          
      Osteosarcoma, Metastatic, Bone                                             1 (2%)                                             
   Salivary Glands                                    (52)         (53)         (53)                                                
   Stomach                                            (53)         (52)         (53)                                                
   Stomach, Forestomach                               (53)         (52)         (53)                                                
   Stomach, Glandular                                 (52)         (52)         (53)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 CARDIOVASCULAR SYSTEM                                                                                                              
                                                                                                                                    
   Heart                                              (52)         (53)         (53)                                                
      Osteosarcoma, Metastatic, Bone                                             1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   6                                                               
NTP Experiment-Test: 05705-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 09/18/94  
Route: GAVAGE                                                                                                     Time: 21:14:43  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      15 MG/KG     30 MG/KG                                               
                                                   MALE          MALE         MALE                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 ENDOCRINE SYSTEM                                                                                                                   
                                                                                                                                    
   Adrenal Gland, Cortex                              (52)         (51)         (53)                                                
      Osteosarcoma, Metastatic, Bone                                             1 (2%)                                             
   Adrenal Gland, Medulla                             (51)         (50)         (53)                                                
      Pheochromocytoma Malignant                       1 (2%)       1 (2%)       1 (2%)                                             
      Pheochromocytoma Benign                         12 (24%)     11 (22%)      8 (15%)                                            
      Bilateral, Pheochromocytoma Benign               5 (10%)      2 (4%)                                                          
   Islets, Pancreatic                                 (52)         (53)         (52)                                                
      Adenoma                                          3 (6%)       1 (2%)       1 (2%)                                             
   Parathyroid Gland                                  (48)         (47)         (37)                                                
      Adenoma                                                       1 (2%)                                                          
   Pituitary Gland                                    (53)         (52)         (53)                                                
      Pars Distalis, Adenoma                          13 (25%)      6 (12%)      5 (9%)                                             
   Thyroid Gland                                      (53)         (53)         (53)                                                
      C-Cell, Adenoma                                  5 (9%)       2 (4%)       1 (2%)                                             
      C-Cell, Carcinoma                                2 (4%)       1 (2%)                                                          
      Follicle, Adenoma                                                          1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENERAL BODY SYSTEM                                                                                                                
                                                                                                                                    
   Tissue NOS                                                      (1)                                                              
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 GENITAL SYSTEM                                                                                                                     
                                                                                                                                    
   Epididymis                                         (52)         (50)         (52)                                                
   Preputial Gland                                    (51)         (52)         (52)                                                
      Squamous Cell Papilloma                          1 (2%)                                                                       
   Prostate                                           (48)         (52)         (53)                                                
   Testes                                             (53)         (51)         (52)                                                
      Bilateral, Interstitial Cell, Adenoma           35 (66%)     38 (75%)     39 (75%)                                            
      Interstitial Cell, Adenoma                      14 (26%)      9 (18%)      6 (12%)                                            
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 HEMATOPOIETIC SYSTEM                                                                                                               
                                                                                                                                    
   Bone Marrow                                        (53)         (52)         (52)                                                
   Lymph Node                                         (53)         (52)         (53)                                                
   Lymph Node, Mesenteric                             (53)         (52)         (53)                                                
   Spleen                                             (53)         (53)         (53)                                                
      Osteosarcoma, Metastatic, Uncertain Primary                                                                                   
          Site                                         1 (2%)                                                                       
   Thymus                                             (47)         (48)         (50)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   7                                                               
NTP Experiment-Test: 05705-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 09/18/94  
Route: GAVAGE                                                                                                     Time: 21:14:43  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      15 MG/KG     30 MG/KG                                               
                                                   MALE          MALE         MALE                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 INTEGUMENTARY SYSTEM                                                                                                               
                                                                                                                                    
   Mammary Gland                                      (53)         (52)         (53)                                                
      Adenoma                                          1 (2%)                                                                       
      Fibroadenoma                                     3 (6%)       3 (6%)       3 (6%)                                             
      Fibroadenoma, Multiple                                                     1 (2%)                                             
   Skin                                               (53)         (51)         (53)                                                
      Keratoacanthoma                                  3 (6%)       3 (6%)                                                          
      Squamous Cell Carcinoma                                       1 (2%)       1 (2%)                                             
      Face, Basal Cell Carcinoma                                                 1 (2%)                                             
      Subcutaneous Tissue, Fibroma                     2 (4%)       3 (6%)       1 (2%)                                             
      Subcutaneous Tissue, Trichoepithelioma                        1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 MUSCULOSKELETAL SYSTEM                                                                                                             
                                                                                                                                    
   Bone                                               (53)         (52)         (52)                                                
      Osteosarcoma                                                               1 (2%)                                             
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 NERVOUS SYSTEM                                                                                                                     
                                                                                                                                    
   Brain                                              (53)         (53)         (53)                                                
      Astrocytoma Malignant                            1 (2%)       1 (2%)                                                          
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 RESPIRATORY SYSTEM                                                                                                                 
                                                                                                                                    
   Lung                                               (53)         (53)         (53)                                                
      Alveolar/Bronchiolar Adenoma, Multiple                        1 (2%)                                                          
      Alveolar/Bronchiolar Carcinoma                                             1 (2%)                                             
      Carcinoma, Metastatic, Zymbal's Gland            1 (2%)                                                                       
      Liposarcoma                                      1 (2%)                                                                       
      Osteosarcoma, Metastatic, Bone                                             1 (2%)                                             
   Nose                                               (52)         (53)         (53)                                                
      Squamous Cell Carcinoma                          2 (4%)                                                                       
   Trachea                                            (53)         (53)         (53)                                                
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SPECIAL SENSES SYSTEM                                                                                                              
                                                                                                                                    
   Zymbal's Gland                                     (1)                       (1)                                                 
      Carcinoma                                        1 (100%)                  1 (100%)                                           
____________________________________________________________________________________________________________________________________
                                                                                                                                    
                                                             Page   8                                                               
NTP Experiment-Test: 05705-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 09/18/94  
Route: GAVAGE                                                                                                     Time: 21:14:43  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      15 MG/KG     30 MG/KG                                               
                                                   MALE          MALE         MALE                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 URINARY SYSTEM                                                                                                                     
                                                                                                                                    
   Kidney                                             (53)         (53)         (53)                                                
      Osteosarcoma, Metastatic, Bone                                             1 (2%)                                             
      Pelvis, Transitional Epithelium, Carcinoma                    1 (2%)                                                          
      Renal Tubule, Adenoma                            1 (2%)                                                                       
   Urinary Bladder                                    (51)         (52)         (53)                                                
      Papilloma                                                                  1 (2%)                                             
      Transitional Epithelium, Papilloma                            1 (2%)                                                          
                                                                                                                                    
____________________________________________________________________________________________________________________________________
                                                                                                                                    
 SYSTEMIC LESIONS                                                                                                                   
   Multiple Organs                                   *(53)        *(53)        *(53)                                                
      Leukemia Mononuclear                            28 (53%)     30 (57%)     20 (38%)                                            
      Mesothelioma Benign                              1 (2%)       3 (6%)       1 (2%)                                             
      Mesothelioma Malignant                           1 (2%)                                                                       
____________________________________________________________________________________________________________________________________
                                                                                                                                    
     *   Number of animals with any tissue examined microscopically                                                                 
                                                             Page   9                                                               
NTP Experiment-Test: 05705-02  INCIDENCE RATES OF NEOPLASMS BY ANATOMIC SITE (SYSTEMIC LESIONS ABRIDGED) (a)      Report: PEIRPT05
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 09/18/94  
Route: GAVAGE                                                                                                     Time: 21:14:43  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
         FISCHER 344 RATS MALE                     CONTROL      15 MG/KG     30 MG/KG                                               
                                                   MALE          MALE         MALE                                                  
____________________________________________________________________________________________________________________________________
                                                                                                                                    
TUMOR SUMMARY                                                                                                                       
                                                                                                                                    
   Total Animals with Primary Neoplasms (b)            52          52          46                                                   
     Total Primary Neoplasms                          138         123          97                                                   
                                                                                                                                    
   Total Animals with Benign Neoplasms                 51          50          46                                                   
     Total Benign Neoplasms                           101          86          69                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms              33          33          24                                                   
     Total Malignant Neoplasms                         37          37          28                                                   
                                                                                                                                    
   Total Animals with Metastatic Neoplasms              1                       1                                                   
     Total Metastatic Neoplasm                          2                       5                                                   
                                                                                                                                    
   Total Animals with Malignant Neoplasms               1                                                                           
   Uncertain Primary Site                                                                                                           
                                                                                                                                    
   Total Animals with Neoplasms Uncertain-                                                                                          
   Benign or Malignant                                                                                                              
     Total Uncertain Neoplasms                                                                                                      
                                                                                                                                    
____________________________________________________________________________________________________________________________________
a  Number of animals examined microscopically at site and number of animals with lesion                                             
b  Primary tumors: all tumors except metastatic tumors                                                                              
                                                             Page  10                                                               
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