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TR 396 Rat Pathology Tables

NTP Experiment-Test: 05705-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97
Route: GAVAGE                                                                                                     Time: 11:37:15




       Facility:  International Research and Development Corp.

       Chemical CAS #:  79-11-8

       Lock Date:  None

       Cage Range:  All

       Reasons For Removal:    All

       Removal Date Range:     All

       Treatment Groups:       Include All






































                                                              Page   1

NTP Experiment-Test: 05705-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 11:37:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 7| 1| 7| 7| 7| 7| 1| 6| 7| 7| 7| 1| 4| 7| 6| 7| 2| 7| 7| 7| 5|             
                             DAY ON TEST   | 5| 3| 3| 3| 2| 8| 3| 3| 2| 3| 8| 7| 2| 3| 3| 8| 5| 3| 5| 3| 1| 2| 2| 3| 9|             
                                           | 6| 2| 2| 1| 9| 3| 1| 0| 9| 0| 3| 5| 9| 1| 0| 3| 6| 1| 3| 1| 5| 9| 9| 0| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    CONTROL                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +  +  +  +     +  +  +  +     +  +  +  +        +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         |    +  +  +  +     +  +  +  +     +  +  +  +        +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    +  +  +  +     +  +  +  +     +  +  +  +        +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +  +  +  +     +  +  +  +     +  +  +  +        +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                   X  X                                                   |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +  +  +  +     +  +  +  +     +  +  +  +        +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                     X                                    |             
                                            __________________________________________________________________________|             
   Intestine Small                         |    +  +  +  +     +  +  +  +     +  +  +  +        +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +  +  +  +     +  +  +  +     +  +  +  +        +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    +  +  +  +     +  +  +  +     +  +  +  +        +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |          2                                                               |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +  +  +  +     +  +  +  +     +  +  +  +        +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   |    +  +  +  +     +  +  +  +     +  +  +  +        +  +  +  +  +  +  +  +|             
      Angiectasis, Focal                   |                                        2                                 |             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     |       X              X  X           X  X  X                       X  X   |             
      Basophilic Focus, Multiple           |    X     X  X     X                                X           X         |             
      Congestion                           |       1                                                                  |             
      Cytoplasmic Alteration, Focal        |          3                 2                                             |             
      Degeneration, Fatty                  |                                                                          |             
      Hemorrhage, Focal                    |                            2                                             |             
      Hepatodiaphragmatic Nodule           |                                                                   X      |             
      Inflammation, Acute, Focal           |                                                                          |             
      Inflammation, Granulomatous,         |                                                                          |             
          Multifocal                       |                            1        2                    1        1      |             
      Necrosis, Acute, Coagulative,        |                                                                          |             
          Multifocal                       |    2                                                                     |             
      Vacuolization Cytoplasmic, Focal     |                                                                2         |             
      Bile Duct, Hyperplasia               |                   1  1                                                   |             
      Hepatocyte, Hypertrophy, Focal       |                                                    2                     |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                       +                  |             
      Inflammation, Chronic, Multifocal    |                                                       2                  |             
      Fat, Necrosis, Focal                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +  +  +  +     +  +  +  +     +  +  +  +        +  +  +  +  +  +  +  +|             
      Atrophy, Focal                       |       1  1                             3                          2  2  1|             
      Inflammation, Chronic, Focal         |                                           1                              |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +  +  +  +     +  +  +  +     +  +  +  +        +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                             3            |             
      Duct, Inflammation, Chronic          |    1                                                                     |             
      Duct, Inflammation, Chronic Active   |                                     1  1                                 |             
                                            __________________________________________________________________________|             
   Stomach                                 |    +  +  +  +     +  +  +  +     +  +  +  +        +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +  +  +  +     +  +  +  +     +  +  +  +        +  +  +  M  +  +  +  +|             
      Inflammation, Acute                  |                                                                         3|             
      Inflammation, Chronic                |                                                       2                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   2                                                               
NTP Experiment-Test: 05705-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 11:37:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 7| 1| 7| 7| 7| 7| 1| 6| 7| 7| 7| 1| 4| 7| 6| 7| 2| 7| 7| 7| 5|             
                             DAY ON TEST   | 5| 3| 3| 3| 2| 8| 3| 3| 2| 3| 8| 7| 2| 3| 3| 8| 5| 3| 5| 3| 1| 2| 2| 3| 9|             
                                           | 6| 2| 2| 1| 9| 3| 1| 0| 9| 0| 3| 5| 9| 1| 0| 3| 6| 1| 3| 1| 5| 9| 9| 0| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    CONTROL                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Inflammation, Chronic Active         |                            2                                             |             
      Epithelium, Hyperplasia              |                            2     2                    3                 2|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +  +  +  +     +  +  +  +     +  +  +  +        +  +  +  +  +  +  +  +|             
      Inflammation, Chronic Active         |                                                                         1|             
      Necrosis, Acute                      |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                         +|             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |    +  +  +  +     +  +  +  +     +  +  +  +        +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Heart                                   |    +  +  +  +     +  +  +  +     +  +  +  +        +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |       2  2  2     1  1  2  1     1  2  1  1              1     1  2  1  1|             
      Atrium Left, Thrombosis              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |    +  +  +  +     +  +  +  +     +  +  +  +        +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |    +  +  +  +     +  +  +  +     +  +  +  +        +  +  +  +  +  +  +  +|             
      Congestion                           |                                                             2            |             
      Ectasia                              |                                           2                              |             
      Hyperplasia, Focal                   |                   2  1  1                          2                     |             
      Hypertrophy, Focal                   |                                                    2                 2   |             
      Hypertrophy                          |             2                                                            |             
      Vacuolization Cytoplasmic, Focal     |          1                       1  2                             1      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |    +  +  +  +     +  +  +  +     +  +  +  +        +  M  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |             3              1                                             |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +  +  +  +     +  +  +  +     +  +  +  +        +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    +  M  +  +     +  +  +  +     +  M  +  +        +  +  +  M  +  +  +  M|             
      Hyperplasia                          |                                                          1               |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |    +  +  +  +     +  +  +  +     +  +  +  +        +  +  +  +  +  +  +  +|             
      Pigmentation, Focal                  |                                                                          |             
      Pars Distalis, Angiectasis           |                                                                          |             
      Pars Distalis, Cyst                  |          2           3              2                                   1|             
      Pars Distalis, Hyperplasia           |             3                          2                 1               |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |    +  +  +  +     +  +  +  +     +  +  +  +        +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |          2                          1     1        1  2        1         |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |    +  +  +  +     +  M  +  +     M  M  +  +        +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |             1                                                            |             
      Inflammation, Chronic                |          1                 1              1                              |             
      Inflammation, Chronic Active         |       2                 1                                         2      |             
                                            __________________________________________________________________________|             
   Ovary                                   |    +  +  +  +     +  +  +  +     +  +  +  +        +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   3                                                               
NTP Experiment-Test: 05705-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 11:37:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 7| 1| 7| 7| 7| 7| 1| 6| 7| 7| 7| 1| 4| 7| 6| 7| 2| 7| 7| 7| 5|             
                             DAY ON TEST   | 5| 3| 3| 3| 2| 8| 3| 3| 2| 3| 8| 7| 2| 3| 3| 8| 5| 3| 5| 3| 1| 2| 2| 3| 9|             
                                           | 6| 2| 2| 1| 9| 3| 1| 0| 9| 0| 3| 5| 9| 1| 0| 3| 6| 1| 3| 1| 5| 9| 9| 0| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    CONTROL                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Hemorrhage                           |                                                             2            |             
      Follicle, Cyst                       |                         2                                                |             
      Periovarian Tissue, Cyst             |                                                                   3      |             
                                            __________________________________________________________________________|             
   Uterus                                  |    +  +  +  +     +  +  +  +     +  +  +  +        +  +  +  +  +  +  +  +|             
      Dilatation                           |                                        3                                 |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Endometrium, Hyperplasia, Cystic     |                                                    2                     |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +  +  +  +     +  +  +  +     +  +  +  +        +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Hypoplasia                           |                                                                          |             
      Myelofibrosis                        |                                                                          |             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +  +  +  +     +  +  +  +     +  +  +  +        +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |    +  +  +  +     +  +  +  +     +  +  +  +        +  +  +  M  +  +  +  +|             
      Edema                                |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  |    +  +  +  +     +  +  +  +     +  +  +  +        +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
          Granulocytic                     |          4                                                               |             
      Pigmentation                         |                                                                   2      |             
                                            __________________________________________________________________________|             
   Thymus                                  |    +  +  +  +     +  +  +  I     +  +  +  +        +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                             1            |             
      Cyst                                 |                                                          2               |             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    +  +  +  +     +  +  +  +     +  +  +  +        +  +  +  +  +  +  +  +|             
      Galactocele                          |       2                             3  3              2                  |             
      Hyperplasia                          |                   1     3           3              1        2  2        1|             
      Duct, Ectasia                        |          2  1           3  3           1  3           1        4     2   |             
                                            __________________________________________________________________________|             
   Skin                                    |    +  +  +  +     +  +  +  +     +  +  +  +        +  +  +  +  +  +  +  +|             
      Subcutaneous Tissue, Hemorrhage      |                                                             3            |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +  +  +  +     +  +  +  +     +  +  +  +        +  +  +  +  +  +  +  +|             
      Osteopetrosis                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +  +  +  +     +  +  +  +     +  +  +  +        +  +  +  +  +  +  +  +|             
      Hydrocephalus                        |                            2                                             |             
      Third Ventricle, Dilatation          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   4                                                               
NTP Experiment-Test: 05705-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 11:37:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 7| 7| 7| 7| 1| 7| 7| 7| 7| 1| 6| 7| 7| 7| 1| 4| 7| 6| 7| 2| 7| 7| 7| 5|             
                             DAY ON TEST   | 5| 3| 3| 3| 2| 8| 3| 3| 2| 3| 8| 7| 2| 3| 3| 8| 5| 3| 5| 3| 1| 2| 2| 3| 9|             
                                           | 6| 2| 2| 1| 9| 3| 1| 0| 9| 0| 3| 5| 9| 1| 0| 3| 6| 1| 3| 1| 5| 9| 9| 0| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|             
    CONTROL                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |    +  +  +  +     +  +  +  +     +  +  +  +        +  +  +  +  +  +  +  +|             
      Congestion                           |                                           1                              |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                                                                         3|             
      Interstitium, Infiltration Cellular, |                                                                          |             
           Multifocal                      |                                                       3                  |             
      Perivascular, Inflammation, Chronic  |    1              1  1                 1                          1      |             
                                            __________________________________________________________________________|             
   Nose                                    |    +  +  +  +     +  +  +  +     +  +  +  +        +  +  +  +  +  +  +  +|             
      Fungus                               |                   X                                            X         |             
      Inflammation, Chronic, Focal         |                                                                          |             
      Mucosa, Inflammation, Chronic Active |                   3                                            3         |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Acute                           |                                                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Chronic Active                  |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 |    +  +  +  +     +  +  +  +     +  +  +  +        +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Lens, Cataract                       |                                                                          |             
      Retina, Degeneration                 |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                        +                                 |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |    +  +  +  +     +  +  +  +     +  +  +  +        +  +  +  +  +  +  +  +|             
      Mineralization, Multifocal           |             1     1                 1              1                     |             
      Nephropathy                          |    1  1  2  2     3  1  3  3        1  2  3        2  2  1     1  3  1  3|             
      Renal Tubule, Epithelium,            |                                                                          |             
          Pigmentation                     |                                                                   2      |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    +  +  +  +     +  +  +  +     +  +  +  +        +  +  +  +  +  +  +  +|             
      Calculus Micro Observation Only,     |                                                                          |             
           Multifocal                      |                                                                          |             
      Hyperplasia, Papillary               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   5                                                               
NTP Experiment-Test: 05705-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 11:37:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 4| 5| 7| 7| 1| 1| 7| 7| 7| 4| 4| 4| 7| 6| 5| 5| 7| 6| 7| 1| 3| 7| 6| 6|             
                             DAY ON TEST   | 8| 5| 6| 3| 2| 8| 8| 3| 3| 3| 5| 5| 5| 3| 2| 2| 5| 2| 3| 3| 8| 4| 2| 9| 9|             
                                           | 3| 6| 5| 1| 9| 3| 3| 0| 0| 0| 6| 6| 6| 2| 6| 0| 8| 9| 7| 1| 3| 4| 9| 3| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |       +  +  +        +  +  +           +  +  +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         |       +  +  +        +  +  +           +  +  +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |       +  +  +        +  +  +           +  +  +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |       +  +  +        +  +  +           +  +  +  +  +  +  +     +  +  +  +|             
      Parasite Metazoan                    |             X              X                                             |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |       +  +  +        +  +  +           +  +  +  +  +  I  +     +  +  +  +|             
      Parasite Metazoan                    |                                                                X         |             
                                            __________________________________________________________________________|             
   Intestine Small                         |       +  +  +        +  +  +           +  +  +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |       +  +  +        +  +  +           +  +  +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |       +  +  +        +  +  +           +  +  +  +  +  +  +     +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |       +  +  +        +  +  +           +  +  +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   |       +  +  +        +  +  +           +  +  +  +  +  +  +     +  +  +  +|             
      Angiectasis, Focal                   |                                                                          |             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     |          X              X                          1     X               |             
      Basophilic Focus, Multiple           |             X        X     X           X  X           X                  |             
      Congestion                           |                                                                          |             
      Cytoplasmic Alteration, Focal        |          2                                                               |             
      Degeneration, Fatty                  |                                                       3                  |             
      Hemorrhage, Focal                    |                                                                          |             
      Hepatodiaphragmatic Nodule           |                         X                                                |             
      Inflammation, Acute, Focal           |                      2  1                                                |             
      Inflammation, Granulomatous,         |                                                                          |             
          Multifocal                       |       2  2  1        2                                2  2     2         |             
      Necrosis, Acute, Coagulative,        |                                                                          |             
          Multifocal                       |                                                                          |             
      Vacuolization Cytoplasmic, Focal     |                                                                          |             
      Bile Duct, Hyperplasia               |       1  1                                                               |             
      Hepatocyte, Hypertrophy, Focal       |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                 +     +                  |             
      Inflammation, Chronic, Multifocal    |                                                                          |             
      Fat, Necrosis, Focal                 |                                                 2     2                  |             
                                            __________________________________________________________________________|             
   Pancreas                                |       +  +  +        +  +  +           +  +  +  +  +  +  +     +  +  +  +|             
      Atrophy, Focal                       |                         2  1              2  1     1           1     1   |             
      Inflammation, Chronic, Focal         |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |       +  +  +        +  +  +           +  +  +  +  +  +  +     +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Duct, Inflammation, Chronic          |                                                                   1      |             
      Duct, Inflammation, Chronic Active   |                         1                          1     1              1|             
                                            __________________________________________________________________________|             
   Stomach                                 |       +  +  +        +  +  +           +  +  +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |       +  +  +        +  +  +           +  +  M  +  +  +  +     +  +  +  +|             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   6                                                               
NTP Experiment-Test: 05705-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 11:37:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 4| 5| 7| 7| 1| 1| 7| 7| 7| 4| 4| 4| 7| 6| 5| 5| 7| 6| 7| 1| 3| 7| 6| 6|             
                             DAY ON TEST   | 8| 5| 6| 3| 2| 8| 8| 3| 3| 3| 5| 5| 5| 3| 2| 2| 5| 2| 3| 3| 8| 4| 2| 9| 9|             
                                           | 3| 6| 5| 1| 9| 3| 3| 0| 0| 0| 6| 6| 6| 2| 6| 0| 8| 9| 7| 1| 3| 4| 9| 3| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Inflammation, Chronic Active         |                                                       4                  |             
      Epithelium, Hyperplasia              |                                           2                              |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |       +  +  +        +  +  +           +  +  +  +  +  +  +     +  +  +  +|             
      Inflammation, Chronic Active         |                                                                          |             
      Necrosis, Acute                      |                                                                         1|             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |       +  +  +        +  +  +           +  +  +     +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Heart                                   |       +  +  +        +  +  +           +  +  +  +  +  +  +     +  +  +  +|             
      Inflammation, Chronic                |          2  2        1  2  1           1  1        1  1  1        1      |             
      Atrium Left, Thrombosis              |                                                                         3|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |       +  +  +        +  +  +           +  +  +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |       +  +  +        +  +  +           +  +  +  +  +  +  +     +  +  +  +|             
      Congestion                           |                                                                          |             
      Ectasia                              |                                                                          |             
      Hyperplasia, Focal                   |                                           1        1                     |             
      Hypertrophy, Focal                   |          1           1                                               2   |             
      Hypertrophy                          |                                                                          |             
      Vacuolization Cytoplasmic, Focal     |             1                             1        1     2               |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |       +  +  +        +  +  +           +  +  +  +  +  +  +     +  +  +  +|             
      Hyperplasia, Focal                   |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |       +  +  +        +  +  +           +  +  +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |       M  M  +        +  +  +           +  +  M  +  +  +  +     M  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |       +  +  +        +  +  +           +  +  +  +  +  +  +     +  +  +  +|             
      Pigmentation, Focal                  |                                                                          |             
      Pars Distalis, Angiectasis           |          3                                   3                       2  1|             
      Pars Distalis, Cyst                  |                         2                                                |             
      Pars Distalis, Hyperplasia           |             2           1                                            2  2|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |       +  +  +        +  +  +           +  +  +  +  +  +  +     +  +  +  +|             
      C-Cell, Hyperplasia                  |                      3  1  1           2                 1              1|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |       +  +  +        +  +  M           +  I  +  I  +  I  +     +  +  +  +|             
      Inflammation, Acute                  |             2                                                     2      |             
      Inflammation, Chronic                |                      1                 3           1     1               |             
      Inflammation, Chronic Active         |          2              2                                                |             
                                            __________________________________________________________________________|             
   Ovary                                   |       +  +  +        +  +  +           +  +  +  +  +  +  +     +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page   7                                                               
NTP Experiment-Test: 05705-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 11:37:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 4| 5| 7| 7| 1| 1| 7| 7| 7| 4| 4| 4| 7| 6| 5| 5| 7| 6| 7| 1| 3| 7| 6| 6|             
                             DAY ON TEST   | 8| 5| 6| 3| 2| 8| 8| 3| 3| 3| 5| 5| 5| 3| 2| 2| 5| 2| 3| 3| 8| 4| 2| 9| 9|             
                                           | 3| 6| 5| 1| 9| 3| 3| 0| 0| 0| 6| 6| 6| 2| 6| 0| 8| 9| 7| 1| 3| 4| 9| 3| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Follicle, Cyst                       |                                                                         3|             
      Periovarian Tissue, Cyst             |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  |       +  +  +        +  +  +           +  +  +  +  +  +  +     +  +  +  +|             
      Dilatation                           |       3                                                                  |             
      Inflammation, Acute                  |                      2                                         3         |             
      Inflammation, Chronic                |                                                                3         |             
      Endometrium, Hyperplasia, Cystic     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |       +  +  +        +  +  +           +  +  +  +  +  +  +     +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Hypoplasia                           |                                                       2                  |             
      Myelofibrosis                        |                                                                2         |             
      Pigmentation                         |       1                                                                  |             
                                            __________________________________________________________________________|             
   Lymph Node                              |       +  +  +        +  +  +           +  +  +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |       +  +  +        +  +  +           +  +  +  +  +  +  +     +  +  +  +|             
      Edema                                |          2                                                               |             
                                            __________________________________________________________________________|             
   Spleen                                  |       +  +  +        +  +  +           +  +  +  +  +  +  +     +  +  +  +|             
      Fibrosis                             |                                                                         3|             
      Hematopoietic Cell Proliferation     |                                                                          |             
          Granulocytic                     |                                           2                              |             
      Pigmentation                         |       2                                               2                  |             
                                            __________________________________________________________________________|             
   Thymus                                  |       +  +  +        +  +  +           +  +  +  +  +  +  +     +  +  +  +|             
      Autolysis                            |                                                                          |             
      Cyst                                 |                                                                          |             
      Hemorrhage                           |                                              2                           |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |       +  +  +        +  +  +           +  +  +  +  +  +  +     +  +  +  +|             
      Galactocele                          |                                                                          |             
      Hyperplasia                          |       2                                1  2  1  3     2                  |             
      Duct, Ectasia                        |             2        1  3  3                             3              1|             
                                            __________________________________________________________________________|             
   Skin                                    |       +  +  +        +  +  +           +  +  +  +  +  +  +     +  +  +  +|             
      Subcutaneous Tissue, Hemorrhage      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |       +  +  +        +  +  +           +  +  +  +  +  +  +     +  +  +  +|             
      Osteopetrosis                        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |       +  +  +        +  +  +           +  +  +  +  +  +  +     +  +  +  +|             
      Hydrocephalus                        |                                                                          |             
      Third Ventricle, Dilatation          |                                                       2                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   8                                                               
NTP Experiment-Test: 05705-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 11:37:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 4| 5| 7| 7| 1| 1| 7| 7| 7| 4| 4| 4| 7| 6| 5| 5| 7| 6| 7| 1| 3| 7| 6| 6|             
                             DAY ON TEST   | 8| 5| 6| 3| 2| 8| 8| 3| 3| 3| 5| 5| 5| 3| 2| 2| 5| 2| 3| 3| 8| 4| 2| 9| 9|             
                                           | 3| 6| 5| 1| 9| 3| 3| 0| 0| 0| 6| 6| 6| 2| 6| 0| 8| 9| 7| 1| 3| 4| 9| 3| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|             
    CONTROL                                | 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|             
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Spinal Cord                             |                                                 +                        |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |       +  +  +        +  +  +           +  +  +  +  +  +  +     +  +  +  +|             
      Congestion                           |                                                                          |             
      Hemorrhage                           |                                              1                           |             
      Inflammation, Chronic                |                                                                   2      |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                                                       1                  |             
      Interstitium, Infiltration Cellular, |                                                                          |             
           Multifocal                      |                                                                          |             
      Perivascular, Inflammation, Chronic  |                         1              1           1                    1|             
                                            __________________________________________________________________________|             
   Nose                                    |       +  +  +        +  M  +           +  +  +  +  +  +  +     +  +  +  +|             
      Fungus                               |                                                                X         |             
      Inflammation, Chronic, Focal         |                                                                   2      |             
      Mucosa, Inflammation, Chronic Active |                                                                2         |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Acute                           |                                                    2                    2|             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Chronic Active                  |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 |       +  +  +        +  +  +           +  +  +  +  +  +  +     +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                      +                                                   |             
      Lens, Cataract                       |                                                                          |             
      Retina, Degeneration                 |                      3                                                   |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |       +  +  +        +  +  +           +  +  +  +  +  +  +     +  +  +  +|             
      Mineralization, Multifocal           |                                                    1              1     1|             
      Nephropathy                          |       1  2  3        2  1  1           3  1        2  2  2     1  2  1  1|             
      Renal Tubule, Epithelium,            |                                                                          |             
          Pigmentation                     |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |       +  +  +        +  +  +           +  +  M  +  +  +  +     +  +  +  +|             
      Calculus Micro Observation Only,     |                                                                          |             
           Multifocal                      |                         X                                                |             
      Hyperplasia, Papillary               |                         4                                                |             
 _____________________________________________________________________________________________________________________|             
                                                             Page   9                                                               
NTP Experiment-Test: 05705-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 11:37:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 5| 7| 6| 7| 1| 7| 7| 6| 7| 1| 7| 7| 7| 7| 1| 6| 7| 7| 7|              |            |
                             DAY ON TEST   | 5| 2| 2| 9| 3| 8| 2| 3| 7| 3| 8| 3| 3| 3| 3| 8| 9| 3| 3| 3|              |            |
                                           | 6| 9| 9| 3| 1| 3| 9| 0| 2| 1| 3| 2| 2| 0| 2| 3| 0| 2| 2| 2|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|              |      A     |
    CONTROL                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|              |      L     |
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |    +  +  +  +     +  +  +  +     +  +  +  +     +  +  +  +               |  53        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |    +  +  +  +     +  +  +  +     +  +  +  +     +  +  +  +               |  53        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |    +  +  +  +     +  +  +  +     +  +  +  +     +  +  +  +               |  53        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |    +  +  +  +     +  +  +  +     +  +  +  +     +  +  +  +               |  53        |
      Parasite Metazoan                    |                            X                       X  X  X               |      8     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |    +  +  +  +     +  +  +  +     +  +  +  +     +  +  +  +               |  52        |
      Parasite Metazoan                    |                                                                          |      2     |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |    +  +  +  +     +  +  +  +     +  +  +  +     +  +  +  +               |  53        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |    +  +  +  +     +  +  +  +     +  +  +  +     +  +  +  +               |  53        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |    +  +  +  +     +  +  +  +     +  +  +  +     +  +  +  +               |  53        |
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |    +  +  +  +     +  +  +  +     +  +  +  +     +  +  +  +               |  53        |
                                            __________________________________________________________________________|____________|
   Liver                                   |    +  +  +  +     +  +  +  +     +  +  +  +     +  +  +  +               |  53        |
      Angiectasis, Focal                   |                                                                          |      1  2.0|
      Angiectasis                          |                      1                                                   |      1  1.0|
      Basophilic Focus                     |          X           X     X                       X                     |     16  1.0|
      Basophilic Focus, Multiple           |       X     X     X              X  X  X  X           X  X               |     21     |
      Congestion                           |                                                                          |      1  1.0|
      Cytoplasmic Alteration, Focal        |                                  3                 2  1                  |      6  2.2|
      Degeneration, Fatty                  |                                                                          |      1  3.0|
      Hemorrhage, Focal                    |                                                                          |      1  2.0|
      Hepatodiaphragmatic Nodule           |             X                             X                              |      4     |
      Inflammation, Acute, Focal           |                                                                          |      2  1.5|
      Inflammation, Granulomatous,         |                                                                          |            |
          Multifocal                       |       2     2        2     2        2  2  1        1  1  2               |     21  1.7|
      Necrosis, Acute, Coagulative,        |                                                                          |            |
          Multifocal                       |                                                                          |      1  2.0|
      Vacuolization Cytoplasmic, Focal     |                                                                          |      1  2.0|
      Bile Duct, Hyperplasia               |                                  2     1           1                     |      7  1.1|
      Hepatocyte, Hypertrophy, Focal       |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                       +                  |   4        |
      Inflammation, Chronic, Multifocal    |                                                                          |      1  2.0|
      Fat, Necrosis, Focal                 |                                                       3                  |      3  2.3|
                                            __________________________________________________________________________|____________|
   Pancreas                                |    +  +  +  +     +  +  +  +     +  +  +  +     +  +  +  +               |  53        |
      Atrophy, Focal                       |    1        1     1                 1     1              1               |     19  1.3|
      Inflammation, Chronic, Focal         |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |    +  +  +  +     +  +  +  +     +  +  +  +     +  +  +  +               |  53        |
      Hemorrhage                           |                                                                          |      1  3.0|
      Duct, Inflammation, Chronic          |                            2     2                 1                     |      5  1.4|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  10                                                               
NTP Experiment-Test: 05705-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 11:37:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 5| 7| 6| 7| 1| 7| 7| 6| 7| 1| 7| 7| 7| 7| 1| 6| 7| 7| 7|              |            |
                             DAY ON TEST   | 5| 2| 2| 9| 3| 8| 2| 3| 7| 3| 8| 3| 3| 3| 3| 8| 9| 3| 3| 3|              |            |
                                           | 6| 9| 9| 3| 1| 3| 9| 0| 2| 1| 3| 2| 2| 0| 2| 3| 0| 2| 2| 2|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|              |      A     |
    CONTROL                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|              |      L     |
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Duct, Inflammation, Chronic Active   |                      1                 1                                 |      8  1.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 |    +  +  +  +     +  +  +  +     +  +  +  +     +  +  +  +               |  53        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |    +  +  +  +     +  +  +  +     +  +  +  +     +  +  +  +               |  51        |
      Inflammation, Acute                  |                                                 2                        |      2  2.5|
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Inflammation, Chronic Active         |                                                                          |      2  3.0|
      Epithelium, Hyperplasia              |                                                 2                        |      6  2.2|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |    +  +  +  +     +  +  +  +     +  +  +  +     +  +  +  +               |  53        |
      Inflammation, Chronic Active         |                                                                          |      1  1.0|
      Necrosis, Acute                      |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |    +  +  +  +        +  +  +     +  +  +  +     +  +  +  +               |  51        |
                                            __________________________________________________________________________|____________|
   Heart                                   |    +  +  +  +     +  +  +  +     +  +  +  +     +  +  +  +               |  53        |
      Inflammation, Chronic                |       2  1  2     1  1  2  1     1  1  1  2        2  2  1               |     41  1.4|
      Atrium Left, Thrombosis              |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |    +  +  +  +     +  +  +  +     +  +  +  +     +  +  +  +               |  53        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |    +  +  +  +     +  +  +  +     +  +  +  +     +  +  +  +               |  53        |
      Congestion                           |                                                                          |      1  2.0|
      Ectasia                              |                                                          2               |      2  2.0|
      Hyperplasia, Focal                   |             1              1     2  2                                    |     10  1.4|
      Hypertrophy, Focal                   |                      2           1        1        1                     |      9  1.4|
      Hypertrophy                          |                                                                          |      1  2.0|
      Vacuolization Cytoplasmic, Focal     |             1     1  2                                                   |     11  1.3|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |    +  +  +  +     +  +  +  +     +  +  +  +     +  +  +  +               |  52        |
      Hyperplasia, Focal                   |             1           1                                                |      4  1.5|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |    +  +  +  +     +  +  +  +     +  +  +  +     +  +  +  +               |  53        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |    +  +  +  +     M  +  +  +     +  +  M  +     +  +  +  +               |  43        |
      Hyperplasia                          |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |    +  +  +  +     +  +  +  +     +  +  +  +     +  +  +  +               |  53        |
      Pigmentation, Focal                  |                            1                                             |      1  1.0|
      Pars Distalis, Angiectasis           |                      2  2                                                |      6  2.2|
      Pars Distalis, Cyst                  |       3     3        2                    2     3                        |     10  2.3|
      Pars Distalis, Hyperplasia           |                         3              2                                 |      9  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |    +  +  +  +     +  +  +  +     +  +  +  +     +  +  +  +               |  53        |
      C-Cell, Hyperplasia                  |       2  2              1  1        1  1           1  1                  |     20  1.4|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  11                                                               
NTP Experiment-Test: 05705-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 11:37:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 5| 7| 6| 7| 1| 7| 7| 6| 7| 1| 7| 7| 7| 7| 1| 6| 7| 7| 7|              |            |
                             DAY ON TEST   | 5| 2| 2| 9| 3| 8| 2| 3| 7| 3| 8| 3| 3| 3| 3| 8| 9| 3| 3| 3|              |            |
                                           | 6| 9| 9| 3| 1| 3| 9| 0| 2| 1| 3| 2| 2| 0| 2| 3| 0| 2| 2| 2|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|              |      A     |
    CONTROL                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|              |      L     |
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |    +  +  +  +     +  +  +  M     +  +  +  +     M  +  +  +               |  44        |
      Inflammation, Acute                  |          3                                            1                  |      5  1.8|
      Inflammation, Chronic                |                   1              1                 1     1               |     11  1.2|
      Inflammation, Chronic Active         |                      1                                                   |      6  1.7|
                                            __________________________________________________________________________|____________|
   Ovary                                   |    +  +  +  +     +  +  +  +     +  +  +  +     +  +  +  +               |  53        |
      Hemorrhage                           |                                                                          |      1  2.0|
      Follicle, Cyst                       |          3  2        3  3                                                |      6  2.7|
      Periovarian Tissue, Cyst             |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  |    +  +  +  +     +  +  +  +     +  +  +  +     +  +  +  +               |  53        |
      Dilatation                           |                                                                          |      2  3.0|
      Inflammation, Acute                  |                                                                          |      2  2.5|
      Inflammation, Chronic                |                                                                          |      1  3.0|
      Endometrium, Hyperplasia, Cystic     |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |    +  +  +  +     +  +  +  +     +  +  +  +     +  +  +  +               |  53        |
      Hyperplasia                          |                            2                                             |      1  2.0|
      Hypoplasia                           |                                                                          |      1  2.0|
      Myelofibrosis                        |                                                 2                        |      2  2.0|
      Pigmentation                         |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |    +  +  +  +     +  +  +  +     +  +  +  +     +  +  +  +               |  53        |
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |    +  +  +  +     +  +  +  +     +  +  +  +     +  +  +  +               |  52        |
      Edema                                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  |    +  +  +  +     +  +  +  +     +  +  +  +     +  +  +  +               |  53        |
      Fibrosis                             |                                                                          |      1  3.0|
      Hematopoietic Cell Proliferation     |                                                                          |            |
          Granulocytic                     |                                                                          |      2  3.0|
      Pigmentation                         |                                                                          |      3  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  |    +  +  +  +     +  M  +  +     +  +  +  +     +  +  +  +               |  51        |
      Autolysis                            |                                                                          |      1  1.0|
      Cyst                                 |                                                    2                     |      2  2.0|
      Hemorrhage                           |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |    +  +  +  +     +  +  +  +     +  +  +  +     +  +  +  +               |  53        |
      Galactocele                          |                                     3                                    |      5  2.6|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  12                                                               
NTP Experiment-Test: 05705-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 11:37:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 5| 7| 6| 7| 1| 7| 7| 6| 7| 1| 7| 7| 7| 7| 1| 6| 7| 7| 7|              |            |
                             DAY ON TEST   | 5| 2| 2| 9| 3| 8| 2| 3| 7| 3| 8| 3| 3| 3| 3| 8| 9| 3| 3| 3|              |            |
                                           | 6| 9| 9| 3| 1| 3| 9| 0| 2| 1| 3| 2| 2| 0| 2| 3| 0| 2| 2| 2|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|              |      A     |
    CONTROL                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|              |      L     |
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia                          |    2  2     3     1  2  2  1        2     1              2               |     23  1.8|
      Duct, Ectasia                        |          1        3              2  2  1  1        2     2               |     24  2.0|
                                            __________________________________________________________________________|____________|
   Skin                                    |    +  +  +  +     +  +  +  +     +  +  +  +     +  +  +  +               |  53        |
      Subcutaneous Tissue, Hemorrhage      |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |    +  +  +  +     +  +  +  +     +  +  +  +     +  +  +  +               |  53        |
      Osteopetrosis                        |                                     3                                    |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |    +  +  +  +     +  +  +  +     +  +  +  +     +  +  +  +               |  53        |
      Hydrocephalus                        |                                                                          |      1  2.0|
      Third Ventricle, Dilatation          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spinal Cord                             |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |    +  +  +  +     +  +  +  +     +  +  +  +     +  +  +  +               |  53        |
      Congestion                           |                                                                          |      1  1.0|
      Hemorrhage                           |                                                                          |      1  1.0|
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |    2                                                                     |      3  2.0|
      Interstitium, Infiltration Cellular, |                                                                          |            |
           Multifocal                      |                                                                          |      1  3.0|
      Perivascular, Inflammation, Chronic  |       1     1        1           1                 1                     |     14  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    |    +  +  +  +     +  +  +  +     +  +  +  +     +  +  +  +               |  52        |
      Fungus                               |    X                                                  X                  |      5     |
      Inflammation, Chronic, Focal         |                                                                          |      1  2.0|
      Mucosa, Inflammation, Chronic Active |    2                                                  2                  |      5  2.4|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Acute                           |                                        1           2                     |      4  1.8|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Chronic Active                  |       1                                                                  |      1  1.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 |    +  +  +  +     +  +  +  +     +  +  +  +     +  +  +  +               |  53        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |             +              +                                             |   3        |
      Lens, Cataract                       |             3              3                                             |      2  3.0|
      Retina, Degeneration                 |             3              3                                             |      3  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  13                                                               
NTP Experiment-Test: 05705-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 11:37:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 5| 7| 6| 7| 1| 7| 7| 6| 7| 1| 7| 7| 7| 7| 1| 6| 7| 7| 7|              |            |
                             DAY ON TEST   | 5| 2| 2| 9| 3| 8| 2| 3| 7| 3| 8| 3| 3| 3| 3| 8| 9| 3| 3| 3|              |            |
                                           | 6| 9| 9| 3| 1| 3| 9| 0| 2| 1| 3| 2| 2| 0| 2| 3| 0| 2| 2| 2|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2| 2|              |      A     |
    CONTROL                                | 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|              |      L     |
    FEMALE                                 | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |    +  +  +  +     +  +  +  +     +  +  +  +     +  +  +  +               |  53        |
      Mineralization, Multifocal           |             1                                            1               |      9  1.0|
      Nephropathy                          |       3     2     1  2  2  1     1  1  2  3        3  1  1               |     46  1.8|
      Renal Tubule, Epithelium,            |                                                                          |            |
          Pigmentation                     |    3                                            2                        |      3  2.3|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |    +  +  +  +     +  +  +  +     +  +  +  +     +  +  +  +               |  52        |
      Calculus Micro Observation Only,     |                                                                          |            |
           Multifocal                      |                                                                          |      1     |
      Hyperplasia, Papillary               |                                                                          |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  14                                                               
NTP Experiment-Test: 05705-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 11:37:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 4| 7| 7| 6| 1| 1| 5| 6| 7| 1| 1| 4| 7| 6| 5| 7| 6| 7| 7| 2| 4| 4| 4| 7|             
                             DAY ON TEST   | 4| 5| 0| 3| 6| 8| 8| 6| 3| 3| 8| 8| 5| 3| 1| 3| 3| 3| 3| 0| 9| 5| 5| 5| 2|             
                                           | 3| 6| 2| 0| 2| 3| 3| 8| 9| 1| 3| 3| 6| 0| 0| 5| 1| 7| 1| 6| 9| 6| 6| 6| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    15 MG/KG                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
     FEMALE                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | M     +  +  +        +  +  +           +  +  +  +  +  +  +  +           +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +     +  +  +        +  +  +           +  +  +  +  +  +  +  +           +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +     +  +  +        +  +  +           +  +  +  +  +  +  +  +           +|             
      Autolysis                            |                                              2              2            |             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +     +  +  +        +  +  +           +  +  +  +  +  +  +  +           +|             
      Autolysis                            |                                              2                           |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +     +  +  +        +  +  +           +  +  +  +  +  +  +  +           +|             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         | +     +  +  +        +  +  +           +  +  +  +  +  +  +  +           +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +     +  +  +        +  +  +           +  +  +  +  +  +  +  +           +|             
      Autolysis                            |                                              2                           |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +     +  +  +        +  +  +           +  +  +  +  +  +  +  +           +|             
      Autolysis                            |                                              4                           |             
      Congestion                           |                                                                          |             
      Edema                                |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +     +  +  +        +  +  +           +  +  +  +  +  +  +  +           +|             
      Autolysis                            |                                              4                           |             
                                            __________________________________________________________________________|             
   Liver                                   | +     +  +  +        +  +  +           +  +  +  +  +  +  +  +           +|             
      Basophilic Focus                     |                                           X                             X|             
      Basophilic Focus, Multiple           |                         X  X           X        X     X                  |             
      Congestion                           |                                                                          |             
      Cytoplasmic Alteration, Focal        |                                                                          |             
      Degeneration, Fatty                  |                                                    4                     |             
      Hepatodiaphragmatic Nodule           |                                              X                           |             
      Inflammation, Granulomatous,         |                                                                          |             
          Multifocal                       |                                           1     1  1                    1|             
      Necrosis, Acute, Focal               |                                                                          |             
      Vacuolization Cytoplasmic, Focal     |                            2                                             |             
      Bile Duct, Hyperplasia               |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +     +  +  +        +  +  +           +  +  +  +  +  +  +  +           +|             
      Atrophy, Focal                       |       2              2                                                  1|             
      Cytoplasmic Alteration, Focal        |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +     +  +  +        +  +  +           +  +  +  +  +  +  +  +           +|             
      Hyperplasia, Focal                   |                                                       1                  |             
                                            __________________________________________________________________________|             
   Stomach                                 | +     +  +  +        +  +  +           +  +  +  +  +  +  +  +           +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +     +  +  +        +  +  +           +  +  +  +  +  +  +  +           +|             
      Inflammation, Acute                  |       2                                            3                     |             
      Inflammation, Chronic Active         |                                                                          |             
      Epithelium, Hyperplasia              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  15                                                               
NTP Experiment-Test: 05705-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 11:37:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 4| 7| 7| 6| 1| 1| 5| 6| 7| 1| 1| 4| 7| 6| 5| 7| 6| 7| 7| 2| 4| 4| 4| 7|             
                             DAY ON TEST   | 4| 5| 0| 3| 6| 8| 8| 6| 3| 3| 8| 8| 5| 3| 1| 3| 3| 3| 3| 0| 9| 5| 5| 5| 2|             
                                           | 3| 6| 2| 0| 2| 3| 3| 8| 9| 1| 3| 3| 6| 0| 0| 5| 1| 7| 1| 6| 9| 6| 6| 6| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    15 MG/KG                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
     FEMALE                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +     +  +  +        +  +  +           +  +  +  +  +  +  +  +           +|             
      Inflammation, Acute                  |                                                                          |             
      Necrosis, Acute                      |       1                                                  1               |             
      Pigmentation, Focal                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +     +  +  +        +  +  +           +  +  +  +  +  +  +  +           +|             
                                            __________________________________________________________________________|             
   Heart                                   | +     +  +  +        +  +  +           +  +  +  +  +  +  +  +           +|             
      Inflammation, Chronic                |             1           1  1           1  1  1     1  1                 1|             
      Atrium Left, Thrombosis              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +     +  +  +        +  +  +           +  +  +  +  +  +  +  +           +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +     +  +  +        +  +  +           +  +  +  +  +  +  +  +           +|             
      Congestion                           |                                                                          |             
      Hemorrhage                           |                                                             2            |             
      Hyperplasia, Focal                   |             2                                                            |             
      Hypertrophy, Focal                   |                            1                                             |             
      Mineralization                       |                                                                          |             
      Necrosis, Acute, Focal               |                                                                          |             
      Thrombosis                           |                         1                                                |             
      Vacuolization Cytoplasmic, Diffuse   |                                                                          |             
      Vacuolization Cytoplasmic, Focal     |       1                                            1                     |             
      Bilateral, Hyperplasia, Focal        |          3                                                               |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | M     +  +  +        +  +  +           +  +  +  +  +  +  +  +           +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +     +  +  +        +  +  +           +  +  +  +  +  +  +  +           +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M     +  +  +        M  +  M           +  +  M  +  +  M  +  +           +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +     +  +  +        +  +  +           +  +  +  +  +  +  +  +           +|             
      Pars Distalis, Angiectasis           |                                        3                                 |             
      Pars Distalis, Cyst                  |       2                                                  1               |             
      Pars Distalis, Hyperplasia           |             2              1              2           1                 2|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | M     +  +  +        +  +  +           +  +  +  +  +  +  +  +           +|             
      Ultimobranchial Cyst                 |                                              1                           |             
      C-Cell, Hyperplasia                  |                            1              1                             1|             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          | +     +  +  +        +  M  +           +  M  +  +  +  +  M  +           M|             
      Hyperplasia                          |                                                                          |             
      Hyperplasia, Squamous                |                                                                          |             
      Inflammation, Acute                  |       2                    1                                             |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  16                                                               
NTP Experiment-Test: 05705-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 11:37:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 4| 7| 7| 6| 1| 1| 5| 6| 7| 1| 1| 4| 7| 6| 5| 7| 6| 7| 7| 2| 4| 4| 4| 7|             
                             DAY ON TEST   | 4| 5| 0| 3| 6| 8| 8| 6| 3| 3| 8| 8| 5| 3| 1| 3| 3| 3| 3| 0| 9| 5| 5| 5| 2|             
                                           | 3| 6| 2| 0| 2| 3| 3| 8| 9| 1| 3| 3| 6| 0| 0| 5| 1| 7| 1| 6| 9| 6| 6| 6| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    15 MG/KG                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
     FEMALE                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Inflammation, Chronic                |                                                    1                     |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Ovary                                   | +     +  +  +        +  +  +           +  +  +  +  +  +  +  +           +|             
      Follicle, Cyst                       |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  | +     +  +  +        +  +  +           +  +  +  +  +  +  +  +           +|             
      Dilatation                           |                                                    2                     |             
      Endometrium, Hyperplasia, Cystic     |                                                                          |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                    +                     |             
      Inflammation, Acute                  |                                                    1                     |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +     +  +  +        +  +  +           +  +  +  +  +  +  +  +           +|             
      Hyperplasia                          |                                                                          |             
      Myelofibrosis                        |                                                          3              2|             
      Myeloid Cell, Hyperplasia            |                         2                    3                           |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +     +  +  +        +  +  +           +  +  +  +  +  +  +  +           +|             
      Renal, Congestion                    |                                                       2                  |             
      Renal, Hemorrhage                    |                                                       2                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +     +  +  +        +  +  +           +  +  +  +  +  +  +  +           +|             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +     +  +  +        +  +  +           +  +  +  +  +  +  +  +           +|             
      Angiectasis                          |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
          Granulocytic                     |                         3                    4        2                  |             
      Inflammation, Focal, Granulomatous   |                                                                          |             
      Necrosis, Focal                      |                                                                          |             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  | +     +  +  +        +  +  +           +  +  +  +  +  I  +  +           +|             
      Hemorrhage                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +     +  +  +        +  +  +           +  +  +  +  +  +  +  +           +|             
      Hyperplasia, Cystic                  |                                                                          |             
      Inflammation, Acute                  |                                              3                           |             
      Duct, Ectasia                        |             1              1           1              1                  |             
                                            __________________________________________________________________________|             
   Skin                                    | +     +  +  +        +  +  +           +  +  +  +  +  +  +  +           +|             
      Face, Inflammation, Acute            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +     +  +  +        +  +  +           +  +  +  +  +  +  +  +           +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +     +  +  +        +  +  +           +  +  +  +  +  +  +  +           +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  17                                                               
NTP Experiment-Test: 05705-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 11:37:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 4| 7| 7| 6| 1| 1| 5| 6| 7| 1| 1| 4| 7| 6| 5| 7| 6| 7| 7| 2| 4| 4| 4| 7|             
                             DAY ON TEST   | 4| 5| 0| 3| 6| 8| 8| 6| 3| 3| 8| 8| 5| 3| 1| 3| 3| 3| 3| 0| 9| 5| 5| 5| 2|             
                                           | 3| 6| 2| 0| 2| 3| 3| 8| 9| 1| 3| 3| 6| 0| 0| 5| 1| 7| 1| 6| 9| 6| 6| 6| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    15 MG/KG                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
     FEMALE                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Hemorrhage, Focal                    |                                                                          |             
      Inflammation, Acute, Focal           |                                                          2               |             
      Inflammation, Chronic, Focal         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +     +  +  +        +  +  +           +  +  +  +  +  +  +  +           +|             
      Congestion                           |                                                             2            |             
      Fibrosis, Focal                      |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                                                          |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                                                 1                        |             
                                            __________________________________________________________________________|             
   Nose                                    | +     +  +  +        +  +  +           +  +  +  +  +  +  +  +           +|             
      Autolysis                            | 2                                            2                          1|             
      Foreign Body                         |                                                                          |             
      Fungus                               |                                                                          |             
      Hemorrhage                           |                                        3                                 |             
      Mucosa, Inflammation, Acute          |       1                 1                                                |             
      Mucosa, Inflammation, Chronic Active |                                                                          |             
      Nasolacrimal Duct, Cyst              |                                                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Acute                           |                                                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Chronic Active                  |                                                                          |             
      Sinus, Inflammation, Acute           |                      2                                                   |             
      Vein, Thrombosis                     |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +     +  +  +        +  +  +           +  +  +  +  +  +  +  +           +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     | +                                                                        |             
      Bilateral, Lens, Cataract            | 3                                                                        |             
      Lens, Cataract                       |                                                                          |             
      Retina, Degeneration                 |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                         +                                                |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +     +  +  +        +  +  +           +  +  +  +  +  +  +  +           +|             
      Autolysis                            |                                                                          |             
      Congestion                           | 3                                         1                              |             
      Hemorrhage                           | 2                                                                        |             
      Mineralization, Focal                |                                                                          |             
      Mineralization, Multifocal           |                                           1                              |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  18                                                               
NTP Experiment-Test: 05705-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 11:37:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 2| 4| 7| 7| 6| 1| 1| 5| 6| 7| 1| 1| 4| 7| 6| 5| 7| 6| 7| 7| 2| 4| 4| 4| 7|             
                             DAY ON TEST   | 4| 5| 0| 3| 6| 8| 8| 6| 3| 3| 8| 8| 5| 3| 1| 3| 3| 3| 3| 0| 9| 5| 5| 5| 2|             
                                           | 3| 6| 2| 0| 2| 3| 3| 8| 9| 1| 3| 3| 6| 0| 0| 5| 1| 7| 1| 6| 9| 6| 6| 6| 9|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|             
    15 MG/KG                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|             
     FEMALE                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Nephropathy                          | 1     2              1     2           2     1  3  3  3  1              1|             
      Cortex, Renal Tubule, Necrosis, Focal|                                                                          |             
      Renal Tubule, Epithelium,            |                                                                          |             
          Pigmentation                     |             3           2                                                |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +     +  +  +        +  M  +           +  +  +  +  +  +  +  +           +|             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Transitional Epithelium, Hyperplasia |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  19                                                               
NTP Experiment-Test: 05705-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 11:37:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 4| 7| 5| 7| 1| 4| 7| 7| 7| 1| 6| 6| 7| 7| 0| 1| 7| 6| 7| 2| 5| 5| 6| 6|             
                             DAY ON TEST   | 8| 2| 3| 8| 3| 8| 5| 2| 3| 3| 8| 7| 7| 3| 3| 0| 8| 3| 7| 3| 4| 0| 7| 3| 5|             
                                           | 3| 7| 2| 4| 0| 3| 6| 9| 2| 2| 3| 4| 7| 1| 2| 3| 3| 0| 9| 1| 3| 4| 5| 9| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    15 MG/KG                               | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
     FEMALE                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +  +  +  +        +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         |    +  +  +  +        +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    +  +  +  +        +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +  +  +  +        +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Parasite Metazoan                    |                                                                         X|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +  +  +  +        +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                                                                         X|             
                                            __________________________________________________________________________|             
   Intestine Small                         |    +  +  +  +        +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +  +  +  +        +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    +  +  +  +        +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Congestion                           |                                                                      2   |             
      Edema                                |                                                                          |             
      Hyperplasia, Lymphoid                |                                        2  2                              |             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +  +  +  +        +  +  +     +  +  +  +  M     +  +  +  +  +  +  +  +|             
      Autolysis                            |                                     3                                    |             
                                            __________________________________________________________________________|             
   Liver                                   |    +  +  +  +        +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Basophilic Focus                     |       X                 X                             X                  |             
      Basophilic Focus, Multiple           |    X        X        X                 X  X        X     X               |             
      Congestion                           |                      2              3                                    |             
      Cytoplasmic Alteration, Focal        |                                  1                                       |             
      Degeneration, Fatty                  |                                                                          |             
      Hepatodiaphragmatic Nodule           |                                                                          |             
      Inflammation, Granulomatous,         |                                                                          |             
          Multifocal                       |             1        2  3        2        2        2                 2  1|             
      Necrosis, Acute, Focal               |                                                       1                  |             
      Vacuolization Cytoplasmic, Focal     |                                                                          |             
      Bile Duct, Hyperplasia               |                                                                         1|             
                                            __________________________________________________________________________|             
   Pancreas                                |    +  +  +  +        +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Atrophy, Focal                       |    1        1              1           2           2  1                  |             
      Cytoplasmic Alteration, Focal        |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +  +  +  +        +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 |    +  +  +  +        +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +  +  +  +        +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Epithelium, Hyperplasia              |       1                          1                                       |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  20                                                               
NTP Experiment-Test: 05705-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 11:37:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 4| 7| 5| 7| 1| 4| 7| 7| 7| 1| 6| 6| 7| 7| 0| 1| 7| 6| 7| 2| 5| 5| 6| 6|             
                             DAY ON TEST   | 8| 2| 3| 8| 3| 8| 5| 2| 3| 3| 8| 7| 7| 3| 3| 0| 8| 3| 7| 3| 4| 0| 7| 3| 5|             
                                           | 3| 7| 2| 4| 0| 3| 6| 9| 2| 2| 3| 4| 7| 1| 2| 3| 3| 0| 9| 1| 3| 4| 5| 9| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    15 MG/KG                               | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
     FEMALE                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +  +  +  +        +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                                                                          |             
      Necrosis, Acute                      |                                     1                 1                  |             
      Pigmentation, Focal                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |    +  +  +  +        +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Heart                                   |    +  +  +  +        +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |    1  1  1  1        1     1        2     2        2     1        1     1|             
      Atrium Left, Thrombosis              |                                     3                                    |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |    +  +  +  +        +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |    +  +  +  +        +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Congestion                           |                                              2                           |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Focal                   |                                  1        2        2                     |             
      Hypertrophy, Focal                   |                                           2                              |             
      Mineralization                       |                         4                                                |             
      Necrosis, Acute, Focal               |                                                                          |             
      Thrombosis                           |                                                                          |             
      Vacuolization Cytoplasmic, Diffuse   |                                                       2        2         |             
      Vacuolization Cytoplasmic, Focal     |                                                                          |             
      Bilateral, Hyperplasia, Focal        |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |    +  +  +  +        +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +  +  +  +        +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    +  +  +  +        +  M  +     +  +  +  +  +     +  +  M  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |    +  +  +  +        +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                                                       2                  |             
      Pars Distalis, Cyst                  |                            3                                             |             
      Pars Distalis, Hyperplasia           |          2                                            2  1     2         |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |    +  +  +  +        +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Ultimobranchial Cyst                 |                                                                          |             
      C-Cell, Hyperplasia                  |       1                    1              2                          1   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |    M  +  +  +        +  +  M     +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Hyperplasia, Squamous                |                                                    2                     |             
      Inflammation, Acute                  |             2        2              3     1        1                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  21                                                               
NTP Experiment-Test: 05705-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 11:37:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 4| 7| 5| 7| 1| 4| 7| 7| 7| 1| 6| 6| 7| 7| 0| 1| 7| 6| 7| 2| 5| 5| 6| 6|             
                             DAY ON TEST   | 8| 2| 3| 8| 3| 8| 5| 2| 3| 3| 8| 7| 7| 3| 3| 0| 8| 3| 7| 3| 4| 0| 7| 3| 5|             
                                           | 3| 7| 2| 4| 0| 3| 6| 9| 2| 2| 3| 4| 7| 1| 2| 3| 3| 0| 9| 1| 3| 4| 5| 9| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    15 MG/KG                               | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
     FEMALE                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Inflammation, Chronic                |       1                                3                                1|             
      Inflammation, Chronic Active         |                                              2                           |             
                                            __________________________________________________________________________|             
   Ovary                                   |    +  +  +  +        +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Follicle, Cyst                       |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  |    +  +  +  +        +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Dilatation                           |       2  2                                   2                           |             
      Endometrium, Hyperplasia, Cystic     |                         2  1                                             |             
                                            __________________________________________________________________________|             
   Vagina                                  |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +  +  +  +        +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Myelofibrosis                        |                                           2                              |             
      Myeloid Cell, Hyperplasia            |    2                                                                     |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +  +  +  +        +  +  +     +  +  +  +  +     +  +  +  +  +  +  M  +|             
      Renal, Congestion                    |                                                                          |             
      Renal, Hemorrhage                    |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |    +  +  +  +        +  +  +     +  +  +  +  +     +  +  +  +  +  +  M  +|             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                                             2            |             
                                            __________________________________________________________________________|             
   Spleen                                  |    +  +  +  +        +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Angiectasis                          |                                                                         2|             
      Hematopoietic Cell Proliferation     |                                                                          |             
          Granulocytic                     |    1                                                                     |             
      Inflammation, Focal, Granulomatous   |                                                                1         |             
      Necrosis, Focal                      |                                                                2         |             
      Pigmentation                         |                                                             2            |             
                                            __________________________________________________________________________|             
   Thymus                                  |    +  +  +  +        +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                              2                           |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    +  +  +  +        +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  |                                  2                                       |             
      Inflammation, Acute                  |                                                                          |             
      Duct, Ectasia                        |       2  2           2                                            1  1  1|             
                                            __________________________________________________________________________|             
   Skin                                    |    +  +  +  +        +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Face, Inflammation, Acute            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +  +  +  +        +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +  +  +  +        +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  22                                                               
NTP Experiment-Test: 05705-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 11:37:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 4| 7| 5| 7| 1| 4| 7| 7| 7| 1| 6| 6| 7| 7| 0| 1| 7| 6| 7| 2| 5| 5| 6| 6|             
                             DAY ON TEST   | 8| 2| 3| 8| 3| 8| 5| 2| 3| 3| 8| 7| 7| 3| 3| 0| 8| 3| 7| 3| 4| 0| 7| 3| 5|             
                                           | 3| 7| 2| 4| 0| 3| 6| 9| 2| 2| 3| 4| 7| 1| 2| 3| 3| 0| 9| 1| 3| 4| 5| 9| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    15 MG/KG                               | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
     FEMALE                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Hemorrhage, Focal                    |                                                                          |             
      Inflammation, Acute, Focal           |                                                                          |             
      Inflammation, Chronic, Focal         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |    +  +  +  +        +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Congestion                           |                                              1              2            |             
      Fibrosis, Focal                      |                                           1                              |             
      Hemorrhage                           |                                                    1                     |             
      Inflammation, Chronic                |                                                                          |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                                          1               |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                                                                2         |             
                                            __________________________________________________________________________|             
   Nose                                    |    +  +  +  +        +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Foreign Body                         |    2                                                                     |             
      Fungus                               |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Mucosa, Inflammation, Acute          |    2     1                                                           2   |             
      Mucosa, Inflammation, Chronic Active |                                                                          |             
      Nasolacrimal Duct, Cyst              |                                                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Acute                           |                                                    2                     |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Chronic Active                  |                                                                          |             
      Sinus, Inflammation, Acute           |                                                                          |             
      Vein, Thrombosis                     |          1                                                               |             
                                            __________________________________________________________________________|             
   Trachea                                 |    +  +  +  +        +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                            M                                             |             
      Bilateral, Lens, Cataract            |                                                                          |             
      Lens, Cataract                       |                                                                          |             
      Retina, Degeneration                 |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |    +  +  +  +        +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Autolysis                            |                                     2                                   2|             
      Congestion                           |                                     2                                    |             
      Hemorrhage                           |                                                                          |             
      Mineralization, Focal                |             1                                                            |             
      Mineralization, Multifocal           |          1                                                               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  23                                                               
NTP Experiment-Test: 05705-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 11:37:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 4| 7| 5| 7| 1| 4| 7| 7| 7| 1| 6| 6| 7| 7| 0| 1| 7| 6| 7| 2| 5| 5| 6| 6|             
                             DAY ON TEST   | 8| 2| 3| 8| 3| 8| 5| 2| 3| 3| 8| 7| 7| 3| 3| 0| 8| 3| 7| 3| 4| 0| 7| 3| 5|             
                                           | 3| 7| 2| 4| 0| 3| 6| 9| 2| 2| 3| 4| 7| 1| 2| 3| 3| 0| 9| 1| 3| 4| 5| 9| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|             
    15 MG/KG                               | 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|             
     FEMALE                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM - cont                     |                                                                          |             
                                           |                                                                          |             
      Nephropathy                          |       3     2        1  1  1     4     1  2        1  1  2     2  2  2  2|             
      Cortex, Renal Tubule, Necrosis, Focal|                                                                2         |             
      Renal Tubule, Epithelium,            |                                                                          |             
          Pigmentation                     |          2                                                               |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    +  +  +  +        +  +  +     +  +  +  +  +     +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |                      1                                                   |             
      Transitional Epithelium, Hyperplasia |                                                    4                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  24                                                               
NTP Experiment-Test: 05705-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 11:37:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 4| 6| 6| 5| 1| 4| 7| 7| 6| 5| 6| 6| 5| 6| 5| 6| 7| 7| 7|              |            |
                             DAY ON TEST   | 8| 9| 4| 0| 9| 8| 5| 2| 2| 3| 3| 4| 4| 8| 7| 5| 2| 2| 2| 3|              |            |
                                           | 3| 4| 7| 0| 6| 3| 6| 9| 5| 0| 9| 4| 4| 8| 2| 0| 4| 9| 9| 2|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|              |      A     |
    15 MG/KG                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|              |      L     |
     FEMALE                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |    +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +               |  52        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |    +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +               |  53        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |    +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +               |  53        |
      Autolysis                            |                                           1                              |      3  1.7|
      Parasite Metazoan                    |                      X                                                   |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |    +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +               |  53        |
      Autolysis                            |                                                                          |      1  2.0|
      Hyperplasia, Lymphoid                |                                                          2               |      1  2.0|
      Parasite Metazoan                    |                      X                          X                        |      3     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |    +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +               |  53        |
      Parasite Metazoan                    |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |    +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +               |  53        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |       +  +  +        +  +  +  M  +  +  +  +  +  +  +  +  +               |  51        |
      Autolysis                            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |    +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +               |  53        |
      Autolysis                            |                                           3     3                        |      3  3.3|
      Congestion                           |    2                                                                     |      2  2.0|
      Edema                                |                                              2                           |      1  2.0|
      Hyperplasia, Lymphoid                |                                                                          |      2  2.0|
      Parasite Metazoan                    |                      X                                                   |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |    +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +               |  52        |
      Autolysis                            |                                                 3                        |      3  3.3|
                                            __________________________________________________________________________|____________|
   Liver                                   |    +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +               |  53        |
      Basophilic Focus                     |                                     X                                    |      6     |
      Basophilic Focus, Multiple           |    X                       X           X           X  X                  |     17     |
      Congestion                           |                                                                          |      2  2.5|
      Cytoplasmic Alteration, Focal        |                                     2              1                     |      3  1.3|
      Degeneration, Fatty                  |                                                                          |      1  4.0|
      Hepatodiaphragmatic Nodule           |                                                                          |      1     |
      Inflammation, Granulomatous,         |                                                                          |            |
          Multifocal                       |    2        2           2  2        2     1           1                  |     19  1.6|
      Necrosis, Acute, Focal               |                                        1                                 |      2  1.0|
      Vacuolization Cytoplasmic, Focal     |                                                                          |      1  2.0|
      Bile Duct, Hyperplasia               |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                |    +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +               |  53        |
      Atrophy, Focal                       |       1  1  1           1                    1           2               |     15  1.3|
      Cytoplasmic Alteration, Focal        |       1                                                                  |      1  1.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |    +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +               |  53        |
      Hyperplasia, Focal                   |                                                                          |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  25                                                               
NTP Experiment-Test: 05705-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 11:37:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 4| 6| 6| 5| 1| 4| 7| 7| 6| 5| 6| 6| 5| 6| 5| 6| 7| 7| 7|              |            |
                             DAY ON TEST   | 8| 9| 4| 0| 9| 8| 5| 2| 2| 3| 3| 4| 4| 8| 7| 5| 2| 2| 2| 3|              |            |
                                           | 3| 4| 7| 0| 6| 3| 6| 9| 5| 0| 9| 4| 4| 8| 2| 0| 4| 9| 9| 2|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|              |      A     |
    15 MG/KG                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|              |      L     |
     FEMALE                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Stomach                                 |    +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +               |  53        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |    +  +  +  +        +  +  +  +  +  +  M  +  +  +  +  +  +               |  52        |
      Inflammation, Acute                  |                                              2                           |      3  2.3|
      Inflammation, Chronic Active         |                      2                                                   |      1  2.0|
      Epithelium, Hyperplasia              |                      3  1                                                |      4  1.5|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |    +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +               |  53        |
      Inflammation, Acute                  |                         1                                                |      1  1.0|
      Necrosis, Acute                      |                                                                          |      4  1.0|
      Pigmentation, Focal                  |                         1                                                |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |    +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +               |  53        |
                                            __________________________________________________________________________|____________|
   Heart                                   |    +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +               |  53        |
      Inflammation, Chronic                |             1           1  1  1        1  1     2  1  2  1               |     31  1.2|
      Atrium Left, Thrombosis              |          2                                                               |      2  2.5|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |    +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +               |  53        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |    +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +               |  53        |
      Congestion                           |                                                                          |      1  2.0|
      Hemorrhage                           |                                              2                           |      2  2.0|
      Hyperplasia, Focal                   |                      1                             2  2  1               |      8  1.6|
      Hypertrophy, Focal                   |          1                                               1               |      4  1.3|
      Mineralization                       |                                                                          |      1  4.0|
      Necrosis, Acute, Focal               |       2                                                                  |      1  2.0|
      Thrombosis                           |                                                                          |      1  1.0|
      Vacuolization Cytoplasmic, Diffuse   |                                                                          |      2  2.0|
      Vacuolization Cytoplasmic, Focal     |          1           1     1           1           1  2  2               |      9  1.2|
      Bilateral, Hyperplasia, Focal        |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |    +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +               |  52        |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |    +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +               |  53        |
      Hyperplasia                          |                         1                                                |      1  1.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |    +  +  +  +        +  +  +  M  +  +  M  +  +  +  +  M  +               |  43        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |    +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +               |  53        |
      Pars Distalis, Angiectasis           |    2                                                  2                  |      4  2.3|
      Pars Distalis, Cyst                  |          3                                                               |      4  2.3|
      Pars Distalis, Hyperplasia           |          2                                      2        2               |     12  1.8|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |    +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +               |  52        |
      Ultimobranchial Cyst                 |                                                                          |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  26                                                               
NTP Experiment-Test: 05705-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 11:37:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 4| 6| 6| 5| 1| 4| 7| 7| 6| 5| 6| 6| 5| 6| 5| 6| 7| 7| 7|              |            |
                             DAY ON TEST   | 8| 9| 4| 0| 9| 8| 5| 2| 2| 3| 3| 4| 4| 8| 7| 5| 2| 2| 2| 3|              |            |
                                           | 3| 4| 7| 0| 6| 3| 6| 9| 5| 0| 9| 4| 4| 8| 2| 0| 4| 9| 9| 2|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|              |      A     |
    15 MG/KG                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|              |      L     |
     FEMALE                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      C-Cell, Hyperplasia                  |                                                          1               |      8  1.1|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |    M  +  +  +        +  +  +  +  +  +  +  M  +  +  +  +  +               |  45        |
      Hyperplasia                          |                                                       3                  |      1  3.0|
      Hyperplasia, Squamous                |                                                                          |      1  2.0|
      Inflammation, Acute                  |             2                                                            |      8  1.8|
      Inflammation, Chronic                |                                                       2  1               |      6  1.5|
      Inflammation, Chronic Active         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Ovary                                   |    +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +               |  53        |
      Follicle, Cyst                       |                                                    1  2                  |      2  1.5|
                                            __________________________________________________________________________|____________|
   Uterus                                  |    +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +               |  53        |
      Dilatation                           |                                                 2                        |      5  2.0|
      Endometrium, Hyperplasia, Cystic     |                                                                          |      2  1.5|
                                            __________________________________________________________________________|____________|
   Vagina                                  |                                                                          |   1        |
      Inflammation, Acute                  |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |    +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +               |  53        |
      Hyperplasia                          |       2                                                                  |      1  2.0|
      Myelofibrosis                        |                                                                          |      3  2.3|
      Myeloid Cell, Hyperplasia            |                                        1                                 |      4  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |    +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +               |  52        |
      Renal, Congestion                    |                                                                          |      1  2.0|
      Renal, Hemorrhage                    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |    +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +               |  52        |
      Hemorrhage                           |                                  2                                       |      1  2.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  |    +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +               |  53        |
      Angiectasis                          |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     |                                                                          |            |
          Granulocytic                     |                                        2                                 |      5  2.4|
      Inflammation, Focal, Granulomatous   |                                                                          |      1  1.0|
      Necrosis, Focal                      |                                                                          |      1  2.0|
      Pigmentation                         |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  |    +  +  +  I        +  +  +  +  +  +  +  +  +  +  +  +  +               |  51        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  27                                                               
NTP Experiment-Test: 05705-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 11:37:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 4| 6| 6| 5| 1| 4| 7| 7| 6| 5| 6| 6| 5| 6| 5| 6| 7| 7| 7|              |            |
                             DAY ON TEST   | 8| 9| 4| 0| 9| 8| 5| 2| 2| 3| 3| 4| 4| 8| 7| 5| 2| 2| 2| 3|              |            |
                                           | 3| 4| 7| 0| 6| 3| 6| 9| 5| 0| 9| 4| 4| 8| 2| 0| 4| 9| 9| 2|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|              |      A     |
    15 MG/KG                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|              |      L     |
     FEMALE                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Hemorrhage                           |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |    +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +               |  53        |
      Hyperplasia, Cystic                  |                                                                          |      1  2.0|
      Inflammation, Acute                  |                                                                          |      1  3.0|
      Duct, Ectasia                        |          2                                                               |     11  1.4|
                                            __________________________________________________________________________|____________|
   Skin                                    |    +  +  +  +        +  +  +  +  +  +  I  +  +  +  +  +  +               |  52        |
      Face, Inflammation, Acute            |                            1                                             |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |    +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +               |  53        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |    +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +               |  53        |
      Hemorrhage, Focal                    |                      1                                                   |      1  1.0|
      Inflammation, Acute, Focal           |                                                                          |      1  2.0|
      Inflammation, Chronic, Focal         |                                                 3                        |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |    +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +               |  53        |
      Congestion                           |             2                             2     2                        |      6  1.8|
      Fibrosis, Focal                      |                                                                          |      1  1.0|
      Hemorrhage                           |                                                                          |      1  1.0|
      Inflammation, Chronic                |                                                    1                     |      1  1.0|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |                                                                          |      1  1.0|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |                            1                                             |      3  1.3|
                                            __________________________________________________________________________|____________|
   Nose                                    |    +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +               |  53        |
      Autolysis                            |                                                 2                        |      4  1.8|
      Foreign Body                         |                                                                          |      1  2.0|
      Fungus                               |                                              X                           |      1     |
      Hemorrhage                           |                                  2                    2                  |      3  2.3|
      Mucosa, Inflammation, Acute          |                               2                                          |      6  1.5|
      Mucosa, Inflammation, Chronic Active |                                     2        3                           |      2  2.5|
      Nasolacrimal Duct, Cyst              |                                        1                                 |      1  1.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Acute                           |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  28                                                               
NTP Experiment-Test: 05705-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 11:37:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 4| 6| 6| 5| 1| 4| 7| 7| 6| 5| 6| 6| 5| 6| 5| 6| 7| 7| 7|              |            |
                             DAY ON TEST   | 8| 9| 4| 0| 9| 8| 5| 2| 2| 3| 3| 4| 4| 8| 7| 5| 2| 2| 2| 3|              |            |
                                           | 3| 4| 7| 0| 6| 3| 6| 9| 5| 0| 9| 4| 4| 8| 2| 0| 4| 9| 9| 2|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5|              |      A     |
    15 MG/KG                               | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|              |      L     |
     FEMALE                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Chronic Active                  |                                        1                                 |      1  1.0|
      Sinus, Inflammation, Acute           |                                                                          |      1  2.0|
      Vein, Thrombosis                     |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 |    +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +               |  53        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |          +                                   +           +               |   4        |
      Bilateral, Lens, Cataract            |                                                                          |      1  3.0|
      Lens, Cataract                       |                                              2           4               |      2  3.0|
      Retina, Degeneration                 |                                                          4               |      1  4.0|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |    +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +               |  53        |
      Autolysis                            |             2                          2  2  2  3                        |      7  2.1|
      Congestion                           |                                                                          |      3  2.0|
      Hemorrhage                           |                                                                          |      1  2.0|
      Mineralization, Focal                |                         1                                                |      2  1.0|
      Mineralization, Multifocal           |                                                                          |      2  1.0|
      Nephropathy                          |    3  1     3        2  1  1     2  3     1        3  2  2               |     38  1.9|
      Cortex, Renal Tubule, Necrosis, Focal|                                                                          |      1  2.0|
      Renal Tubule, Epithelium,            |                                                                          |            |
          Pigmentation                     |          2                                                               |      4  2.3|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |    +  +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +               |  52        |
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  1.0|
      Transitional Epithelium, Hyperplasia |                                                                          |      1  4.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  29                                                               
NTP Experiment-Test: 05705-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 11:37:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 4| 6| 7| 7| 1| 1| 2| 5| 7| 1| 3| 7| 7| 7| 1| 4| 7| 5| 6| 1| 4| 4| 6| 7|             
                             DAY ON TEST   | 8| 5| 1| 3| 3| 8| 8| 8| 9| 2| 8| 4| 3| 3| 3| 8| 5| 0| 9| 4| 8| 5| 5| 7| 3|             
                                           | 3| 6| 6| 1| 1| 3| 3| 3| 9| 9| 3| 0| 1| 1| 0| 3| 6| 3| 7| 7| 3| 6| 6| 9| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    30 MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     FEMALE                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |       +  +  +        +  I  +     +  +  +  +        +  +  +           +  +|             
      Inflammation, Acute, Focal           |                                                       2                  |             
                                            __________________________________________________________________________|             
   Intestine Large                         |       +  +  +        +  +  +     +  +  +  +        +  +  +           +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |       +  +  +        +  +  +     +  +  +  +        +  +  +           +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |       +  +  +        +  +  +     +  +  +  +        +  +  +           +  +|             
      Parasite Metazoan                    |                                  X                                       |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |       +  +  +        I  M  +     +  +  +  +        +  +  +           +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Parasite Metazoan                    |                                                                          |             
      Submucosa, Inflammation, Acute, Focal|                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small                         |       +  +  +        +  +  +     +  +  +  +        +  +  +           +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |       +  +  +        +  +  +     +  +  +  +        +  +  +           +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |       +  +  +        +  +  +     +  +  +  +        +  +  +           +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |       +  +  +        +  +  +     +  +  +  +        +  +  +           +  +|             
                                            __________________________________________________________________________|             
   Liver                                   |       +  +  +        +  +  +     +  +  +  +        +  +  +           +  +|             
      Angiectasis, Focal                   |             2                                                            |             
      Basophilic Focus                     |          X              X                 X        X  X                  |             
      Basophilic Focus, Multiple           |             X              X        X  X                                X|             
      Congestion                           |                                                                          |             
      Cytoplasmic Alteration, Focal        |                                           1        2                     |             
      Hepatodiaphragmatic Nodule           |                      X                                                   |             
      Inflammation, Acute, Focal           |                                                                          |             
      Inflammation, Granulomatous,         |                                                                          |             
          Multifocal                       |          2  2                       1  2                                1|             
      Necrosis, Acute, Focal               |                                                                          |             
      Bile Duct, Hyperplasia               |                                           1                              |             
                                            __________________________________________________________________________|             
   Mesentery                               |          +                                                               |             
      Inflammation, Chronic, Multifocal    |                                                                          |             
      Fat, Necrosis, Focal                 |          3                                                               |             
                                            __________________________________________________________________________|             
   Pancreas                                |       +  +  +        +  +  +     +  +  +  +        +  +  +           +  +|             
      Atrophy, Focal                       |       1                                                  1               |             
      Acinus, Hyperplasia                  |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |       +  +  +        +  +  +     +  +  +  +        +  +  +           +  +|             
      Atrophy, Focal                       |                                                                          |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |                                                                      2   |             
      Inflammation, Chronic                |                                                                          |             
      Duct, Inflammation, Chronic          |             1                                                            |             
      Duct, Inflammation, Chronic Active   |          1                                                               |             
                                            __________________________________________________________________________|             
   Stomach                                 |       +  +  +        +  +  +     +  +  +  +        +  +  +           +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |       +  +  +        +  +  +     +  +  +  +        +  +  +           +  +|             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Ulcer                                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  30                                                               
NTP Experiment-Test: 05705-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 11:37:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 4| 6| 7| 7| 1| 1| 2| 5| 7| 1| 3| 7| 7| 7| 1| 4| 7| 5| 6| 1| 4| 4| 6| 7|             
                             DAY ON TEST   | 8| 5| 1| 3| 3| 8| 8| 8| 9| 2| 8| 4| 3| 3| 3| 8| 5| 0| 9| 4| 8| 5| 5| 7| 3|             
                                           | 3| 6| 6| 1| 1| 3| 3| 3| 9| 9| 3| 0| 1| 1| 0| 3| 6| 3| 7| 7| 3| 6| 6| 9| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    30 MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     FEMALE                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Epithelium, Hyperplasia              |                                                                         1|             
      Muscularis, Hypertrophy, Focal       |                                                                          |             
      Submucosa, Inflammation, Acute       |                                                                         1|             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |       +  +  +        +  +  +     +  +  +  +        +  +  +           +  +|             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |                                                                          |             
      Inflammation, Acute                  |                                                                      2   |             
      Necrosis, Acute                      |                                                                      2   |             
      Arteriole, Submucosa, Thrombosis     |                                                                      3   |             
      Serosa, Inflammation, Chronic,       |                                                                          |             
          Multifocal                       |                                           2                              |             
      Submucosa, Inflammation, Chronic     |                                                                         2|             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                      +   |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |       +  +  +        +  +  +     +  +  +  +        +  +  +           +  +|             
                                            __________________________________________________________________________|             
   Heart                                   |       +  +  +        +  +  +     +  +  +  +        +  +  +           +  +|             
      Inflammation, Chronic                |          1  2        1  1  1        2  1  1                             1|             
      Coronary Artery, Inflammation,       |                                                                          |             
          Chronic                          |                                                                          |             
      Pericardium, Fibrosis, Focal         |                                                                          |             
      Valve, Thrombosis                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |       +  +  +        +  +  +     +  +  +  +        +  +  +           +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |       +  +  +        +  +  +     +  +  +  +        +  +  +           +  +|             
      Angiectasis, Focal                   |                            2                                             |             
      Congestion                           |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Focal                   |                            1        1     2                          1   |             
      Hypertrophy, Focal                   |          1                 1                                             |             
      Vacuolization Cytoplasmic, Focal     |       2                 1                                            1   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |       +  +  +        +  +  +     +  +  +  +        +  +  +           +  +|             
      Hyperplasia, Focal                   |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |       +  +  +        +  +  +     +  +  +  +        +  +  +           +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |       +  +  +        +  +  +     M  +  +  +        +  +  I           +  +|             
      Congestion, Focal                    |                                                                         2|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |       +  +  +        +  +  +     +  +  +  +        +  +  +           +  +|             
      Autolysis                            |                                                                          |             
      Congestion, Focal                    |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Pars Distalis, Angiectasis           |                                                          3           3  2|             
      Pars Distalis, Cyst                  |          2                                                              2|             
      Pars Distalis, Ectasia               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  31                                                               
NTP Experiment-Test: 05705-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 11:37:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 4| 6| 7| 7| 1| 1| 2| 5| 7| 1| 3| 7| 7| 7| 1| 4| 7| 5| 6| 1| 4| 4| 6| 7|             
                             DAY ON TEST   | 8| 5| 1| 3| 3| 8| 8| 8| 9| 2| 8| 4| 3| 3| 3| 8| 5| 0| 9| 4| 8| 5| 5| 7| 3|             
                                           | 3| 6| 6| 1| 1| 3| 3| 3| 9| 9| 3| 0| 1| 1| 0| 3| 6| 3| 7| 7| 3| 6| 6| 9| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    30 MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     FEMALE                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pars Distalis, Hyperplasia           |                      1     2        2                                    |             
      Pars Distalis, Vacuolization Nuclear |                                                                         2|             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |       +  +  +        +  +  +     +  +  +  +        +  +  +           +  +|             
      Ultimobranchial Cyst                 |                                                                          |             
      C-Cell, Hyperplasia                  |             1                          1  1                          1  3|             
      Follicle, Cyst                       |                                                                          |             
      Follicular Cell, Hyperplasia         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |       +  +  +        +  +  +     +  +  +  +        +  +  +           +  +|             
      Hyperplasia                          |                                                    2                     |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |             1                                                           1|             
      Inflammation, Chronic Active         |                            3                                             |             
                                            __________________________________________________________________________|             
   Ovary                                   |       +  +  +        +  +  +     +  +  +  +        +  +  +           +  +|             
      Atrophy                              |                                                                          |             
      Follicle, Cyst                       |                                                    2                     |             
      Periovarian Tissue, Cyst             |                                                                          |             
                                            __________________________________________________________________________|             
   Uterus                                  |       +  +  +        +  +  +     +  +  +  +        +  +  +           +  +|             
      Dilatation                           |                                                          3               |             
      Hemorrhage                           |                                                          3               |             
      Endometrium, Fibrosis                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |       +  +  +        +  +  +     +  +  +  +        +  +  +           +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |       +  +  +        +  +  +     +  +  +  +        +  +  +           +  +|             
      Mediastinal, Congestion              |                                                                      1   |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |       +  +  +        +  +  +     +  +  +  +        +  +  +           +  +|             
      Congestion                           |                                                                          |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Lymphocyte, Depletion Cellular       |                                                                      2   |             
                                            __________________________________________________________________________|             
   Spleen                                  |       +  +  +        +  +  +     +  +  +  +        +  +  +           +  +|             
      Fibrosis                             |       2                                                                  |             
      Pigmentation                         |                                                                          |             
      Capsule, Fibrosis, Multifocal        |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  |       +  +  +        +  I  I     +  +  M  +        +  +  +           +  +|             
      Cyst                                 |                                                                          |             
      Hemorrhage                           |                      3                                                   |             
      Hyperplasia, Lymphoid                |                                                                          |             
      Medulla, Hyperplasia, Focal          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  32                                                               
NTP Experiment-Test: 05705-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 11:37:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 4| 6| 7| 7| 1| 1| 2| 5| 7| 1| 3| 7| 7| 7| 1| 4| 7| 5| 6| 1| 4| 4| 6| 7|             
                             DAY ON TEST   | 8| 5| 1| 3| 3| 8| 8| 8| 9| 2| 8| 4| 3| 3| 3| 8| 5| 0| 9| 4| 8| 5| 5| 7| 3|             
                                           | 3| 6| 6| 1| 1| 3| 3| 3| 9| 9| 3| 0| 1| 1| 0| 3| 6| 3| 7| 7| 3| 6| 6| 9| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    30 MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     FEMALE                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |       +  +  +        +  +  +     +  +  +  +        +  +  +           +  +|             
      Galactocele                          |                                                                      3   |             
      Hyperplasia                          |       1     1              1           1           1     2              2|             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic Active,        |                                                                          |             
          Multifocal                       |                                                                          |             
      Duct, Ectasia                        |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    |       +  +  +        +  +  +     +  +  +  +        +  +  +           +  +|             
      Face, Inflammation, Chronic Active,  |                                                                          |             
           Focal                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |       +  +  +        +  +  +     +  +  +  +        +  +  +           +  +|             
      Hyperostosis                         |       2                                                                  |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |       +  +  +        +  +  +     +  +  +  +        +  +  +           +  +|             
      Congestion                           |                                                                          |             
      Cerebellum, Cyst                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |       +  +  +        +  +  +     +  +  +  +        +  +  +           +  +|             
      Congestion                           |                      2  2        3                                       |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Chronic                |                            1                                             |             
      Inflammation, Granulomatous,         |                                                                          |             
          Multifocal                       |                                                                          |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                           2                              |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                                                                          |             
      Perivascular, Inflammation, Chronic  |          1                 1                                             |             
                                            __________________________________________________________________________|             
   Nose                                    |       +  +  +        +  A  +     +  +  +  +        +  +  +           +  +|             
      Foreign Body                         |                                                                          |             
      Fungus                               |                            X                                             |             
      Mucosa, Inflammation, Acute          |                                                       3                  |             
      Mucosa, Inflammation, Chronic Active |                            2                                             |             
      Nasolacrimal Duct, Cyst              |                                           1                              |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Acute                           |                                                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Chronic                         |                            2              2                          2   |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  33                                                               
NTP Experiment-Test: 05705-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 11:37:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 4| 6| 7| 7| 1| 1| 2| 5| 7| 1| 3| 7| 7| 7| 1| 4| 7| 5| 6| 1| 4| 4| 6| 7|             
                             DAY ON TEST   | 8| 5| 1| 3| 3| 8| 8| 8| 9| 2| 8| 4| 3| 3| 3| 8| 5| 0| 9| 4| 8| 5| 5| 7| 3|             
                                           | 3| 6| 6| 1| 1| 3| 3| 3| 9| 9| 3| 0| 1| 1| 0| 3| 6| 3| 7| 7| 3| 6| 6| 9| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7|             
    30 MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
     FEMALE                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
           Chronic Active                  |             1                                                            |             
      Sinus, Inflammation, Acute           |                      1                                                   |             
                                            __________________________________________________________________________|             
   Trachea                                 |       +  +  +        +  +  +     +  +  +  +        +  +  +           +  +|             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                            +                                             |             
      Lens, Cataract                       |                            3                                             |             
      Retina, Degeneration                 |                            3                                             |             
      Sclera, Mineralization, Focal        |                            1                                             |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |       +  +  +        +  +  +     +  +  +  +        +  +  +           +  +|             
      Autolysis                            |                                                                          |             
      Congestion                           |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Inflammation, Multifocal, Suppurative|                                                                          |             
      Mineralization, Multifocal           |             1              1     1                       1               |             
      Nephropathy                          |       1  1  2           1  1        3  2  1        2  1  1              1|             
      Cortex, Renal Tubule, Necrosis       |                                                                          |             
      Renal Tubule, Epithelium,            |                                                                          |             
          Pigmentation                     |                                                                      2   |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |       +  +  +        +  +  +     +  +  +  +        +  +  +           M  +|             
      Hemorrhage, Focal                    |                                                    2                     |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  34                                                               
NTP Experiment-Test: 05705-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 11:37:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 2| 7| 7| 7| 4| 7| 7| 5| 7| 2| 2| 4| 5| 7| 4| 7| 7| 7| 7| 3| 3| 5| 6| 7|             
                             DAY ON TEST   | 8| 7| 2| 3| 3| 5| 3| 2| 9| 3| 5| 5| 5| 3| 3| 5| 3| 3| 3| 3| 3| 5| 1| 6| 1|             
                                           | 3| 0| 9| 2| 0| 6| 0| 9| 3| 2| 3| 7| 6| 9| 0| 6| 1| 2| 2| 0| 1| 1| 2| 2| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    30 MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
     FEMALE                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +  +  +  +     +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute, Focal           |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         |    +  +  +  +     +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    +  +  +  +     +  +  +  +  +  +     +  +     +  +  +  +  M  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +  +  +  +     +  +  +  +  M  +     +  +     +  +  +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                            X     X                          X        X  X|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +  +  +  +     +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Parasite Metazoan                    |                                           X                             X|             
      Submucosa, Inflammation, Acute, Focal|          2                                                               |             
                                            __________________________________________________________________________|             
   Intestine Small                         |    +  +  +  +     +  +  +  +  A  +     +  +     +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +  +  +  +     +  +  +  +  A  +     +  +     +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    +  +  +  +     +  +  +  +  A  +     +  +     +  +  +  +  A  A  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +  +  +  +     +  +  +  +  A  +     +  +     +  +  +  +  A  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   |    +  +  +  +     +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +|             
      Angiectasis, Focal                   |                                                                          |             
      Basophilic Focus                     |       X           X                                X     X     X  X      |             
      Basophilic Focus, Multiple           |             X              X              X           X              X   |             
      Congestion                           |                                                                          |             
      Cytoplasmic Alteration, Focal        |                                           2                          2   |             
      Hepatodiaphragmatic Nodule           |                      X                          X                        |             
      Inflammation, Acute, Focal           |                                                                          |             
      Inflammation, Granulomatous,         |                                                                          |             
          Multifocal                       |                   3                             2  2     2        1      |             
      Necrosis, Acute, Focal               |                         1                                                |             
      Bile Duct, Hyperplasia               |                            1                                            1|             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Inflammation, Chronic, Multifocal    |                                                                          |             
      Fat, Necrosis, Focal                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +  +  +  +     +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +|             
      Atrophy, Focal                       |                                        1        1  2        1        1  2|             
      Acinus, Hyperplasia                  |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +  +  +  +     +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +|             
      Atrophy, Focal                       |                      1                                                   |             
      Infiltration Cellular, Multifocal,   |                                                                          |             
           Lymphocyte                      |                                                                          |             
      Inflammation, Chronic                |                                                          1               |             
      Duct, Inflammation, Chronic          |                                                                          |             
      Duct, Inflammation, Chronic Active   |       1           2        1                          1        1         |             
                                            __________________________________________________________________________|             
   Stomach                                 |    +  +  +  +     +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +  +  +  +     +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                                                                3         |             
      Inflammation, Chronic                |                                                                          |             
      Ulcer                                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  35                                                               
NTP Experiment-Test: 05705-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 11:37:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 2| 7| 7| 7| 4| 7| 7| 5| 7| 2| 2| 4| 5| 7| 4| 7| 7| 7| 7| 3| 3| 5| 6| 7|             
                             DAY ON TEST   | 8| 7| 2| 3| 3| 5| 3| 2| 9| 3| 5| 5| 5| 3| 3| 5| 3| 3| 3| 3| 3| 5| 1| 6| 1|             
                                           | 3| 0| 9| 2| 0| 6| 0| 9| 3| 2| 3| 7| 6| 9| 0| 6| 1| 2| 2| 0| 1| 1| 2| 2| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    30 MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
     FEMALE                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Epithelium, Hyperplasia              |                                                                         1|             
      Muscularis, Hypertrophy, Focal       |                                                                         2|             
      Submucosa, Inflammation, Acute       |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +  +  +  +     +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Necrosis, Acute                      |                                                                          |             
      Arteriole, Submucosa, Thrombosis     |                                                                          |             
      Serosa, Inflammation, Chronic,       |                                                                          |             
          Multifocal                       |                                                                          |             
      Submucosa, Inflammation, Chronic     |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |    +  +  +  +     +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Heart                                   |    +  +  +  +     +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |    1  2  1  1     1        1           1  1     1  2  1  1     1     1  1|             
      Coronary Artery, Inflammation,       |                                                                          |             
          Chronic                          |                                                                          |             
      Pericardium, Fibrosis, Focal         |                                                       2                  |             
      Valve, Thrombosis                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |    +  +  +  +     +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |    +  +  +  +     +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +|             
      Angiectasis, Focal                   |                                                                          |             
      Congestion                           |                                                                          |             
      Hemorrhage                           |                                                             3            |             
      Hyperplasia, Focal                   |       2                                   1           1                  |             
      Hypertrophy, Focal                   |             1                                                            |             
      Vacuolization Cytoplasmic, Focal     |                         1                                                |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |    +  +  +  +     +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                                       1                  |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +  +  +  +     +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    +  +  +  +     M  M  +  +  +  +     M  +     +  +  +  +  +  +  M  +  M|             
      Congestion, Focal                    |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |    +  +  +  +     +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Congestion, Focal                    |                               2                                          |             
      Hemorrhage                           |                                                                          |             
      Pars Distalis, Angiectasis           |                                                       3                  |             
      Pars Distalis, Cyst                  |    1                                               3              2      |             
      Pars Distalis, Ectasia               |       4                                                                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  36                                                               
NTP Experiment-Test: 05705-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 11:37:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 2| 7| 7| 7| 4| 7| 7| 5| 7| 2| 2| 4| 5| 7| 4| 7| 7| 7| 7| 3| 3| 5| 6| 7|             
                             DAY ON TEST   | 8| 7| 2| 3| 3| 5| 3| 2| 9| 3| 5| 5| 5| 3| 3| 5| 3| 3| 3| 3| 3| 5| 1| 6| 1|             
                                           | 3| 0| 9| 2| 0| 6| 0| 9| 3| 2| 3| 7| 6| 9| 0| 6| 1| 2| 2| 0| 1| 1| 2| 2| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    30 MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
     FEMALE                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Pars Distalis, Hyperplasia           |                            2                    1  2  2                  |             
      Pars Distalis, Vacuolization Nuclear |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |    +  +  +  +     +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +|             
      Ultimobranchial Cyst                 |                                                                          |             
      C-Cell, Hyperplasia                  |       1  1  1           1                       3  1  1                  |             
      Follicle, Cyst                       |                                                                          |             
      Follicular Cell, Hyperplasia         |                                                                      2   |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Clitoral Gland                          |    +  +  +  +     +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                                          |             
      Inflammation, Acute                  |                                                                1        2|             
      Inflammation, Chronic                |       1  1              1                       1     2  1               |             
      Inflammation, Chronic Active         |                   2        3                       2                     |             
                                            __________________________________________________________________________|             
   Ovary                                   |    +  +  +  +     +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Follicle, Cyst                       |                            2                                             |             
      Periovarian Tissue, Cyst             |                                        3                                 |             
                                            __________________________________________________________________________|             
   Uterus                                  |    +  +  +  +     +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +|             
      Dilatation                           |                                           3                              |             
      Hemorrhage                           |                                                                          |             
      Endometrium, Fibrosis                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +  +  +  +     +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +  +  +  +     +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +|             
      Mediastinal, Congestion              |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |    +  +  +  +     +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hyperplasia, Lymphoid                |    3                                                                     |             
      Lymphocyte, Depletion Cellular       |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  |    +  +  +  +     +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
      Pigmentation                         |    2                    2                                      2         |             
      Capsule, Fibrosis, Multifocal        |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  |    +  +  +  +     +  +  +  +  +  +     +  +     +  +  +  I  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia, Lymphoid                |    2                                                                     |             
      Medulla, Hyperplasia, Focal          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  37                                                               
NTP Experiment-Test: 05705-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 11:37:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 2| 7| 7| 7| 4| 7| 7| 5| 7| 2| 2| 4| 5| 7| 4| 7| 7| 7| 7| 3| 3| 5| 6| 7|             
                             DAY ON TEST   | 8| 7| 2| 3| 3| 5| 3| 2| 9| 3| 5| 5| 5| 3| 3| 5| 3| 3| 3| 3| 3| 5| 1| 6| 1|             
                                           | 3| 0| 9| 2| 0| 6| 0| 9| 3| 2| 3| 7| 6| 9| 0| 6| 1| 2| 2| 0| 1| 1| 2| 2| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    30 MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
     FEMALE                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    +  +  +  +     +  +  +  +  +  +     +  M     +  +  +  +  +  I  +  +  +|             
      Galactocele                          |       2                                            2                     |             
      Hyperplasia                          |       1     3        2  1                       2     2           1      |             
      Inflammation, Acute                  |                                                    2                     |             
      Inflammation, Chronic Active,        |                                                                          |             
          Multifocal                       |                                                                          |             
      Duct, Ectasia                        |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    |    +  +  +  +     +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +|             
      Face, Inflammation, Chronic Active,  |                                                                          |             
           Focal                           |                                                       2                  |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +  +  +  +     +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +|             
      Hyperostosis                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +  +  +  +     +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                      1   |             
      Cerebellum, Cyst                     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |    +  +  +  +     +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +|             
      Congestion                           |    3                          2  2                          2  3     2  2|             
      Hemorrhage                           |                                                                          |             
      Inflammation, Chronic                |                                                 1        1               |             
      Inflammation, Granulomatous,         |                                                                          |             
          Multifocal                       |                                                                   2      |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                           1                              |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                                                                          |             
      Perivascular, Inflammation, Chronic  |       1           1                                1     1               |             
                                            __________________________________________________________________________|             
   Nose                                    |    +  +  +  M     +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +|             
      Foreign Body                         |                                                                   1      |             
      Fungus                               |                                                                          |             
      Mucosa, Inflammation, Acute          |                                        2                    1  2  3      |             
      Mucosa, Inflammation, Chronic Active |                                                                          |             
      Nasolacrimal Duct, Cyst              |                                                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Acute                           |       3              2                          3                        |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Chronic                         |                                                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  38                                                               
NTP Experiment-Test: 05705-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 11:37:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 2| 7| 7| 7| 4| 7| 7| 5| 7| 2| 2| 4| 5| 7| 4| 7| 7| 7| 7| 3| 3| 5| 6| 7|             
                             DAY ON TEST   | 8| 7| 2| 3| 3| 5| 3| 2| 9| 3| 5| 5| 5| 3| 3| 5| 3| 3| 3| 3| 3| 5| 1| 6| 1|             
                                           | 3| 0| 9| 2| 0| 6| 0| 9| 3| 2| 3| 7| 6| 9| 0| 6| 1| 2| 2| 0| 1| 1| 2| 2| 7|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
    30 MG/KG                               | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
     FEMALE                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
           Chronic Active                  |          1                 1                                             |             
      Sinus, Inflammation, Acute           |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 |    +  +  +  +     +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                    1                     |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                          |             
      Lens, Cataract                       |                                                                          |             
      Retina, Degeneration                 |                                                                          |             
      Sclera, Mineralization, Focal        |                                                                          |             
                                            __________________________________________________________________________|             
   Harderian Gland                         |                                                                   +      |             
      Inflammation, Chronic                |                                                                   1      |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |    +  +  +  +     +  +  +  +  +  +     +  +     +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                        2                                 |             
      Congestion                           |                                                                      1   |             
      Hemorrhage                           |                               3                                          |             
      Inflammation, Multifocal, Suppurative|                                                                          |             
      Mineralization, Multifocal           |          1  1              1                          1  1  1  1     2   |             
      Nephropathy                          |       2  2  2     3  2     1              1     2  2  2  1              2|             
      Cortex, Renal Tubule, Necrosis       |                                                                          |             
      Renal Tubule, Epithelium,            |                                                                          |             
          Pigmentation                     |                         2                                                |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    +  +  +  +     +  +  +  +  M  +     +  +     M  +  +  +  +  +  +  +  +|             
      Hemorrhage, Focal                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  39                                                               
NTP Experiment-Test: 05705-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 11:37:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 1| 5| 5| 6| 2| 4| 7| 7| 7| 1| 4| 6| 7| 7| 7| 7| 7| 7| 7|              |            |
                             DAY ON TEST   | 8| 8| 6| 8| 8| 9| 9| 2| 2| 2| 8| 5| 8| 2| 2| 3| 3| 3| 3| 3|              |            |
                                           | 3| 3| 8| 2| 2| 4| 7| 9| 2| 9| 3| 8| 2| 9| 4| 1| 2| 1| 0| 1|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|              |      A     |
    30 MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |      L     |
     FEMALE                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |       +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +               |  52        |
      Inflammation, Acute, Focal           |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large                         |       +  +  +  A  +  +  +  +     +  +  +  +  +  +  +  +  +               |  52        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |       +  +  +  A  +  +  +  +     +  +  +  +  +  +  +  +  +               |  51        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |       +  +  +  A  +  +  +  +     +  +  +  +  +  +  +  +  +               |  51        |
      Parasite Metazoan                    |                                                                          |      6     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |       +  +  +  A  +  +  +  +     +  +  +  +  +  +  +  +  +               |  50        |
      Hyperplasia, Lymphoid                |                                              2                           |      1  2.0|
      Parasite Metazoan                    |                      X                                                   |      3     |
      Submucosa, Inflammation, Acute, Focal|                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small                         |       +  +  +  A  +  +  +  +     +  +  +  +  +  +  +  +  +               |  51        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |       +  +  +  A  +  +  +  +     +  +  +  +  +  +  +  +  +               |  51        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |       A  +  +  A  +  +  +  +     +  +  +  +  +  +  +  +  +               |  48        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |       A  +  +  A  +  +  +  +     +  +  +  +  +  +  +  +  +               |  49        |
                                            __________________________________________________________________________|____________|
   Liver                                   |       +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +               |  53        |
      Angiectasis, Focal                   |                                                                          |      1  2.0|
      Basophilic Focus                     |                   X     X        X     X  X                              |     16     |
      Basophilic Focus, Multiple           |                                                 X  X  X  X               |     14     |
      Congestion                           |                         1                                                |      1  1.0|
      Cytoplasmic Alteration, Focal        |                                                                          |      4  1.8|
      Hepatodiaphragmatic Nodule           |                                                                          |      3     |
      Inflammation, Acute, Focal           |                            2                          1                  |      2  1.5|
      Inflammation, Granulomatous,         |                                                                          |            |
          Multifocal                       |          1        1  1                 1        1  1  1  1               |     18  1.4|
      Necrosis, Acute, Focal               |                                                                          |      1  1.0|
      Bile Duct, Hyperplasia               |                                                                          |      3  1.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                                    +                     |   2        |
      Inflammation, Chronic, Multifocal    |                                                    1                     |      1  1.0|
      Fat, Necrosis, Focal                 |                                                    3                     |      2  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                |       +  +  +  M  +  +  I  +     +  +  +  +  +  +  +  +  +               |  51        |
      Atrophy, Focal                       |                   2                 1                                    |     10  1.3|
      Acinus, Hyperplasia                  |                      2                                                   |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |       +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +               |  53        |
      Atrophy, Focal                       |                                                                          |      1  1.0|
      Infiltration Cellular, Multifocal,   |                                                                          |            |
           Lymphocyte                      |                                     2                                    |      2  2.0|
      Inflammation, Chronic                |                                                                          |      1  1.0|
      Duct, Inflammation, Chronic          |                      1                                                   |      2  1.0|
      Duct, Inflammation, Chronic Active   |                   1                                                      |      7  1.1|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  40                                                               
NTP Experiment-Test: 05705-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 11:37:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 1| 5| 5| 6| 2| 4| 7| 7| 7| 1| 4| 6| 7| 7| 7| 7| 7| 7| 7|              |            |
                             DAY ON TEST   | 8| 8| 6| 8| 8| 9| 9| 2| 2| 2| 8| 5| 8| 2| 2| 3| 3| 3| 3| 3|              |            |
                                           | 3| 3| 8| 2| 2| 4| 7| 9| 2| 9| 3| 8| 2| 9| 4| 1| 2| 1| 0| 1|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|              |      A     |
    30 MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |      L     |
     FEMALE                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Stomach                                 |       +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +               |  53        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |       +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +               |  53        |
      Inflammation, Acute                  |                                                                          |      1  3.0|
      Inflammation, Chronic                |                            2                                             |      1  2.0|
      Ulcer                                |             4                                                            |      1  4.0|
      Epithelium, Hyperplasia              |                            2                 2                           |      4  1.5|
      Muscularis, Hypertrophy, Focal       |                                                                          |      1  2.0|
      Submucosa, Inflammation, Acute       |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |       +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +               |  53        |
      Infiltration Cellular, Focal,        |                                                                          |            |
          Lymphocyte                       |                                                          2               |      1  2.0|
      Inflammation, Acute                  |                                                                          |      1  2.0|
      Necrosis, Acute                      |             2                       2                                    |      3  2.0|
      Arteriole, Submucosa, Thrombosis     |                                                                          |      1  3.0|
      Serosa, Inflammation, Chronic,       |                                                                          |            |
          Multifocal                       |                                                                          |      1  2.0|
      Submucosa, Inflammation, Chronic     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Tongue                                  |       +                                         +                        |   3        |
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |       +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +               |  53        |
                                            __________________________________________________________________________|____________|
   Heart                                   |       +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +               |  53        |
      Inflammation, Chronic                |       1  1        1  1  1  1        1  1        1  1  1  1               |     36  1.1|
      Coronary Artery, Inflammation,       |                                                                          |            |
          Chronic                          |                                           3                              |      1  3.0|
      Pericardium, Fibrosis, Focal         |                                                                          |      1  2.0|
      Valve, Thrombosis                    |                                              2                           |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |       +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +               |  53        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |       +  +  +  A  +  +  +  +     +  +  +  +  +  +  +  +  +               |  52        |
      Angiectasis, Focal                   |                                                                          |      1  2.0|
      Congestion                           |                                                       2  1               |      2  1.5|
      Hemorrhage                           |                                                                          |      1  3.0|
      Hyperplasia, Focal                   |                   1  2     2     2              1                        |     12  1.4|
      Hypertrophy, Focal                   |                                        2                                 |      4  1.3|
      Vacuolization Cytoplasmic, Focal     |                            3                          1                  |      6  1.5|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |       +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +               |  53        |
      Hyperplasia, Focal                   |             1                       2        2                           |      4  1.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  41                                                               
NTP Experiment-Test: 05705-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 11:37:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 1| 5| 5| 6| 2| 4| 7| 7| 7| 1| 4| 6| 7| 7| 7| 7| 7| 7| 7|              |            |
                             DAY ON TEST   | 8| 8| 6| 8| 8| 9| 9| 2| 2| 2| 8| 5| 8| 2| 2| 3| 3| 3| 3| 3|              |            |
                                           | 3| 3| 8| 2| 2| 4| 7| 9| 2| 9| 3| 8| 2| 9| 4| 1| 2| 1| 0| 1|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|              |      A     |
    30 MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |      L     |
     FEMALE                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |       +  +  +  M  +  +  I  +     +  +  +  +  +  +  +  +  +               |  51        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |       +  +  +  M  +  +  +  M     M  +  +  M  +  +  +  +  +               |  42        |
      Congestion, Focal                    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |       +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +               |  53        |
      Autolysis                            |       2                                                                  |      1  2.0|
      Congestion, Focal                    |                                                                          |      1  2.0|
      Hemorrhage                           |       2        2                                                         |      2  2.0|
      Pars Distalis, Angiectasis           |                            1                                             |      5  2.4|
      Pars Distalis, Cyst                  |                                     2        2                           |      7  2.0|
      Pars Distalis, Ectasia               |                                                                          |      1  4.0|
      Pars Distalis, Hyperplasia           |             2     1        2     2                 2  1                  |     13  1.7|
      Pars Distalis, Vacuolization Nuclear |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |       +  +  +  +  +  +  +  +     M  +  +  +  +  +  +  +  +               |  52        |
      Ultimobranchial Cyst                 |       X                                                                  |      1     |
      C-Cell, Hyperplasia                  |          1  2              1           1                                 |     16  1.3|
      Follicle, Cyst                       |                         X                                                |      1     |
      Follicular Cell, Hyperplasia         |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Clitoral Gland                          |       +  +  M  +  M  +  +  +     M  +  +  +  M  +  +  M  +               |  48        |
      Hyperplasia                          |                                                                          |      1  2.0|
      Inflammation, Acute                  |                      3  2                                                |      4  2.0|
      Inflammation, Chronic                |                      2                 1        1        1               |     12  1.2|
      Inflammation, Chronic Active         |       2                                                                  |      5  2.4|
                                            __________________________________________________________________________|____________|
   Ovary                                   |       +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +               |  53        |
      Atrophy                              |          3                                                               |      1  3.0|
      Follicle, Cyst                       |          3                             1           2                     |      5  2.0|
      Periovarian Tissue, Cyst             |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Uterus                                  |       +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +               |  53        |
      Dilatation                           |                                                       3                  |      3  3.0|
      Hemorrhage                           |                                                                          |      1  3.0|
      Endometrium, Fibrosis                |             3                                                            |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |       +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +               |  53        |
                                            __________________________________________________________________________|____________|
   Lymph Node                              |       +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +               |  53        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  42                                                               
NTP Experiment-Test: 05705-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 11:37:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 1| 5| 5| 6| 2| 4| 7| 7| 7| 1| 4| 6| 7| 7| 7| 7| 7| 7| 7|              |            |
                             DAY ON TEST   | 8| 8| 6| 8| 8| 9| 9| 2| 2| 2| 8| 5| 8| 2| 2| 3| 3| 3| 3| 3|              |            |
                                           | 3| 3| 8| 2| 2| 4| 7| 9| 2| 9| 3| 8| 2| 9| 4| 1| 2| 1| 0| 1|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|              |      A     |
    30 MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |      L     |
     FEMALE                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
      Mediastinal, Congestion              |                                     1                                    |      2  1.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |       +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +               |  53        |
      Congestion                           |                                     1                                    |      1  1.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  3.0|
      Lymphocyte, Depletion Cellular       |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  |       +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +               |  53        |
      Fibrosis                             |                                                                          |      1  2.0|
      Pigmentation                         |                         3                                                |      4  2.3|
      Capsule, Fibrosis, Multifocal        |                                     2                                    |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  |       I  +  +  +  +  +  +  I     +  +  M  I  +  +  +  +  M               |  44        |
      Cyst                                 |                                                       2                  |      1  2.0|
      Hemorrhage                           |                                                                          |      1  3.0|
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
      Medulla, Hyperplasia, Focal          |                                                    2                     |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |       +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +               |  51        |
      Galactocele                          |       X                    2                                             |      5  2.3|
      Hyperplasia                          |       2  1  2     1              1        1  3     2                     |     23  1.5|
      Inflammation, Acute                  |                                                                          |      1  2.0|
      Inflammation, Chronic Active,        |                                                                          |            |
          Multifocal                       |                                                    1                     |      1  1.0|
      Duct, Ectasia                        |                                     1  2                                 |      2  1.5|
                                            __________________________________________________________________________|____________|
   Skin                                    |       +  +  +  +  +  +  M  +     +  +  +  +  +  +  +  +  +               |  52        |
      Face, Inflammation, Chronic Active,  |                                                                          |            |
           Focal                           |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |       +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +               |  53        |
      Hyperostosis                         |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |       +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +               |  53        |
      Congestion                           |                                           2                              |      2  1.5|
      Cerebellum, Cyst                     |          3                                                               |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |       +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +               |  53        |
      Congestion                           |                2  3                       2                              |     13  2.3|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  43                                                               
NTP Experiment-Test: 05705-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 11:37:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 1| 5| 5| 6| 2| 4| 7| 7| 7| 1| 4| 6| 7| 7| 7| 7| 7| 7| 7|              |            |
                             DAY ON TEST   | 8| 8| 6| 8| 8| 9| 9| 2| 2| 2| 8| 5| 8| 2| 2| 3| 3| 3| 3| 3|              |            |
                                           | 3| 3| 8| 2| 2| 4| 7| 9| 2| 9| 3| 8| 2| 9| 4| 1| 2| 1| 0| 1|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|              |      A     |
    30 MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |      L     |
     FEMALE                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
      Hemorrhage                           |       2                                                                  |      1  2.0|
      Inflammation, Chronic                |                                                                          |      3  1.0|
      Inflammation, Granulomatous,         |                                                                          |            |
          Multifocal                       |                                                                          |      1  2.0|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |                                                                          |      2  1.5|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |       1                             1                                    |      2  1.0|
      Perivascular, Inflammation, Chronic  |                            1        1  2        1  1     1               |     12  1.1|
                                            __________________________________________________________________________|____________|
   Nose                                    |       A  +  +  A  A  +  +  +     +  +  +  +  +  +  +  +  +               |  48        |
      Foreign Body                         |                                                                          |      1  1.0|
      Fungus                               |                                                                          |      1     |
      Mucosa, Inflammation, Acute          |                                                                          |      5  2.2|
      Mucosa, Inflammation, Chronic Active |                                                                          |      1  2.0|
      Nasolacrimal Duct, Cyst              |                                                                          |      1  1.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Acute                           |                      3              2           3                        |      6  2.7|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Chronic                         |                                        1                                 |      4  1.8|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Chronic Active                  |                                                                          |      3  1.0|
      Sinus, Inflammation, Acute           |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 |       +  +  +  +  +  +  +  +     +  +  +  +  +  +  +  +  +               |  53        |
      Inflammation, Chronic                |                      1                                                   |      2  1.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                                    +                     |   2        |
      Lens, Cataract                       |                                                    2                     |      2  2.5|
      Retina, Degeneration                 |                                                    2                     |      2  2.5|
      Sclera, Mineralization, Focal        |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Harderian Gland                         |                                                                          |   1        |
      Inflammation, Chronic                |                                                                          |      1  1.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |       +  +  +  A  +  +  +  +     +  +  +  +  +  +  +  +  +               |  52        |
      Autolysis                            |                                                                          |      1  2.0|
      Congestion                           |                                                                          |      1  1.0|
      Hemorrhage                           |                                                                          |      1  3.0|
      Inflammation, Multifocal, Suppurative|                                     3                                    |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  44                                                               
NTP Experiment-Test: 05705-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 11:37:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 1| 5| 5| 6| 2| 4| 7| 7| 7| 1| 4| 6| 7| 7| 7| 7| 7| 7| 7|              |            |
                             DAY ON TEST   | 8| 8| 6| 8| 8| 9| 9| 2| 2| 2| 8| 5| 8| 2| 2| 3| 3| 3| 3| 3|              |            |
                                           | 3| 3| 8| 2| 2| 4| 7| 9| 2| 9| 3| 8| 2| 9| 4| 1| 2| 1| 0| 1|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS FEMALE                 | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8| 8|              |      A     |
    30 MG/KG                               | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |      L     |
     FEMALE                                | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 URINARY SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Mineralization, Multifocal           |          1                             1              1                  |     15  1.1|
      Nephropathy                          |          1           2  1  3        1  2  1  2  2  2     1               |     35  1.6|
      Cortex, Renal Tubule, Necrosis       |                         4                                                |      1  4.0|
      Renal Tubule, Epithelium,            |                                                                          |            |
          Pigmentation                     |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |       +  +  +  +  +  +  I  +     +  +  +  +  +  +  +  +  +               |  49        |
      Hemorrhage, Focal                    |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  45                                                               
NTP Experiment-Test: 05705-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 11:37:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 7| 7| 7| 1| 1| 2| 7| 5| 3| 5| 7| 7| 6| 7| 7| 7| 6| 7| 1| 4| 4| 7| 5|             
                             DAY ON TEST   | 5| 5| 3| 3| 0| 8| 8| 9| 2| 8| 5| 1| 3| 3| 9| 1| 3| 2| 7| 3| 8| 4| 5| 3| 8|             
                                           | 6| 6| 2| 2| 5| 3| 3| 1| 9| 4| 0| 2| 1| 2| 3| 8| 2| 9| 4| 0| 3| 7| 6| 0| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |       +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         |       +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |       +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +|             
      Inflammation, Acute                  |                                                                          |             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |       +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +|             
      Infiltration Cellular, Lymphocyte    |                                     2                                    |             
      Parasite Metazoan                    |          X  X                       X     X                          X   |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |       +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +|             
      Inflammation, Acute                  |                                                                          |             
      Parasite Metazoan                    |                            X                       X  X                  |             
                                            __________________________________________________________________________|             
   Intestine Small                         |       +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |       +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +|             
      Autolysis                            |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |       +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +|             
      Autolysis                            |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |       +  +  +        A  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +|             
      Autolysis                            |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   |       +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +|             
      Angiectasis, Focal                   |                                                                          |             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     |                         X              2                             X   |             
      Basophilic Focus, Multiple           |          X                                                               |             
      Congestion                           |                                                                          |             
      Cytoplasmic Alteration, Focal        |                         2              3        2  2  3                  |             
      Cytoplasmic Alteration, Multifocal   |                                                                      2   |             
      Fatty Change, Diffuse                |                                  2                                       |             
      Fatty Change, Multifocal             |                                                                          |             
      Inflammation, Granulomatous,         |                                                                          |             
          Multifocal                       |                                                          2               |             
      Necrosis, Acute, Focal               |                                                                          |             
      Pigmentation, Diffuse                |                                                                          |             
      Thrombosis                           |                                                                      2   |             
      Vacuolization Cytoplasmic, Focal     |                                                                          |             
      Artery, Thrombosis                   |                                                                          |             
      Bile Duct, Hyperplasia               |          1  3        2              1     3  3        2        2     1   |             
      Hepatocyte, Degeneration, Cystic,    |                                                                          |             
           Focal                           |                                        2     2           1               |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Fat, Necrosis, Chronic, Multifocal   |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |       +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +|             
      Atrophy, Focal                       |       1  1                       1                             2        2|             
      Cytoplasmic Alteration, Focal        |                         1                                                |             
      Artery, Inflammation, Chronic        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  46                                                               
NTP Experiment-Test: 05705-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 11:37:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 7| 7| 7| 1| 1| 2| 7| 5| 3| 5| 7| 7| 6| 7| 7| 7| 6| 7| 1| 4| 4| 7| 5|             
                             DAY ON TEST   | 5| 5| 3| 3| 0| 8| 8| 9| 2| 8| 5| 1| 3| 3| 9| 1| 3| 2| 7| 3| 8| 4| 5| 3| 8|             
                                           | 6| 6| 2| 2| 5| 3| 3| 1| 9| 4| 0| 2| 1| 2| 3| 8| 2| 9| 4| 0| 3| 7| 6| 0| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |       +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +|             
      Atrophy, Diffuse                     |                                              1                           |             
      Duct, Ectasia, Focal                 |                                  2                                       |             
                                            __________________________________________________________________________|             
   Stomach                                 |       +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |       +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +|             
      Hyperplasia                          |                                                                          |             
      Inflammation, Acute                  |                                                          2               |             
      Inflammation, Chronic                |                            3                                             |             
      Necrosis, Focal                      |                                                                          |             
      Epithelium, Hyperplasia              |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |       +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +|             
      Inflammation, Acute                  |                                              2                           |             
      Inflammation, Chronic                |                                                                          |             
      Mineralization                       |                                                                2         |             
      Necrosis, Focal                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |       +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +|             
                                            __________________________________________________________________________|             
   Heart                                   |       +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +|             
      Fibrosis, Focal                      |             3                                3                           |             
      Inflammation, Chronic                |       2  1           2  2  3  1  2  2  1  2     1  2  2  1     2     2  3|             
      Mineralization                       |                                                                          |             
      Artery, Mineralization, Multifocal   |                                                                2         |             
      Atrium Left, Thrombosis              |             4                                                            |             
      Valve, Thrombosis                    |                                              3                           |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |       +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |       +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +|             
      Hyperplasia, Focal                   |          2              1              1                                 |             
      Hypertrophy, Focal                   |       1                                                                  |             
      Necrosis, Focal                      |                                              1                           |             
      Vacuolization Cytoplasmic, Diffuse   |                                                                          |             
      Vacuolization Cytoplasmic, Focal     |          1                                               1               |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |       +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +|             
      Hyperplasia, Focal                   |                            2                    2                        |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |       +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +|             
      Hyperplasia, Focal                   |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |       +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |       +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +|             
      Pars Distalis, Angiectasis           |                                                          1               |             
      Pars Distalis, Cyst                  |                         2                                                |             
      Pars Distalis, Hyperplasia           |       2              2  1                                               1|             
      Pars Nervosa, Hyperplasia            |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  47                                                               
NTP Experiment-Test: 05705-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 11:37:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 7| 7| 7| 1| 1| 2| 7| 5| 3| 5| 7| 7| 6| 7| 7| 7| 6| 7| 1| 4| 4| 7| 5|             
                             DAY ON TEST   | 5| 5| 3| 3| 0| 8| 8| 9| 2| 8| 5| 1| 3| 3| 9| 1| 3| 2| 7| 3| 8| 4| 5| 3| 8|             
                                           | 6| 6| 2| 2| 5| 3| 3| 1| 9| 4| 0| 2| 1| 2| 3| 8| 2| 9| 4| 0| 3| 7| 6| 0| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |       +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +|             
      Ultimobranchial Cyst                 |                                                                          |             
      C-Cell, Hyperplasia                  |                                           3  2     1                     |             
      Follicular Cell, Hyperplasia         |          1                                1                              |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |       +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +|             
      Duct, Epithelium, Degeneration       |                            3                                             |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |       +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +     +     M  +|             
      Inflammation, Acute                  |                         1              1  2                              |             
      Inflammation, Chronic                |       1              2  1     1  2           2           2               |             
      Duct, Hyperplasia, Squamous          |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                |       +  +  +        +  +  +  +  +  +  +  +  +  M  +  +  +     +     M  I|             
      Hyperplasia, Focal                   |                         1                                                |             
      Inflammation, Acute                  |                         2           1                 2        3         |             
      Inflammation, Chronic                |                                                                          |             
      Epithelium, Degeneration, Focal      |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |       M  M  M        M  M  M  M  M  M  M  M  M  M  M  M  M     M     M  M|             
                                            __________________________________________________________________________|             
   Testes                                  |       +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +|             
      Atrophy                              |                            3                       3  2                  |             
      Mineralization, Focal                |                                                                         1|             
      Bilateral, Interstitial Cell,        |                                                                          |             
          Hyperplasia                      |                                                                          |             
      Interstitial Cell, Hyperplasia       |             2                    2                       1     1         |             
      Seminiferous Tubule, Degeneration    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |       +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +|             
      Hyperplasia, Megakaryocyte           |                                                                         3|             
      Hyperplasia                          |                                           2                              |             
      Hypoplasia                           |                                                                          |             
      Myeloid Cell, Hyperplasia            |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |       +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +|             
      Axillary, Congestion                 |                                                                          |             
      Iliac, Hyperplasia, Plasma Cell      |                                                                          |             
      Iliac, Inflammation, Focal,          |                                                                          |             
          Granulomatous                    |                                                                          |             
      Inguinal, Inflammation, Acute,       |                                                                          |             
          Multifocal                       |                                           2                              |             
      Mediastinal, Congestion              |                            2                    2                        |             
      Mediastinal, Hyperplasia             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  48                                                               
NTP Experiment-Test: 05705-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 11:37:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 7| 7| 7| 1| 1| 2| 7| 5| 3| 5| 7| 7| 6| 7| 7| 7| 6| 7| 1| 4| 4| 7| 5|             
                             DAY ON TEST   | 5| 5| 3| 3| 0| 8| 8| 9| 2| 8| 5| 1| 3| 3| 9| 1| 3| 2| 7| 3| 8| 4| 5| 3| 8|             
                                           | 6| 6| 2| 2| 5| 3| 3| 1| 9| 4| 0| 2| 1| 2| 3| 8| 2| 9| 4| 0| 3| 7| 6| 0| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Pancreatic, Congestion               |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |       +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +|             
      Congestion                           |                                                                          |             
      Hyperplasia                          |                                              1                           |             
                                            __________________________________________________________________________|             
   Spleen                                  |       +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +|             
      Fibrosis, Focal                      |                                                                          |             
      Fibrosis                             |                            2                                             |             
      Hematopoietic Cell Proliferation     |                                                                          |             
          Granulocytic                     |                                                                          |             
      Hemorrhage, Multifocal               |                                                                          |             
      Pigmentation, Diffuse                |                                                                2         |             
      Capsule, Fibrosis, Focal             |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  |       I  I  +        +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +|             
      Cyst, Multiple                       |                                                                          |             
      Hemorrhage                           |                      2                                                   |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |       +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +|             
      Hyperplasia, Cystic                  |                                                                          |             
      Hyperplasia                          |                                                                          |             
      Duct, Ectasia                        |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    |       +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +|             
      Inflammation, Acute                  |                                                                          |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Acute                           |                                                                          |             
      Subcutaneous Tissue, Necrosis        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |       +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +|             
      Fibrous Osteodystrophy               |                            2                                             |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |       +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +|             
      Congestion                           |                                                                          |             
      Hemorrhage, Focal                    |                                                       2                  |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |       +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +|             
      Congestion                           |                      2                                                   |             
      Inflammation, Acute, Focal           |                               2                                          |             
      Inflammation, Chronic                |                                                                         3|             
      Inflammation, Focal, Granulomatous   |                                        2  2                              |             
      Mineralization, Focal                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  49                                                               
NTP Experiment-Test: 05705-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 11:37:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 7| 7| 7| 1| 1| 2| 7| 5| 3| 5| 7| 7| 6| 7| 7| 7| 6| 7| 1| 4| 4| 7| 5|             
                             DAY ON TEST   | 5| 5| 3| 3| 0| 8| 8| 9| 2| 8| 5| 1| 3| 3| 9| 1| 3| 2| 7| 3| 8| 4| 5| 3| 8|             
                                           | 6| 6| 2| 2| 5| 3| 3| 1| 9| 4| 0| 2| 1| 2| 3| 8| 2| 9| 4| 0| 3| 7| 6| 0| 5|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                         1                                                |             
      Perivascular, Inflammation, Chronic  |       1                                                              1   |             
                                            __________________________________________________________________________|             
   Nose                                    |       +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +|             
      Cyst                                 |                                              1                           |             
      Fungus                               |       X                                                                  |             
      Mucosa, Concretion, Focal            |                                                                          |             
      Mucosa, Inflammation, Acute          |                               3  2                                       |             
      Mucosa, Inflammation, Chronic Active |       3                                2                       1         |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Acute                           |                         2                       2                        |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Chronic                         |                                                                          |             
      Respiratory Epithelium, Hyperplasia  |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 |       +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +|             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                            +                          +                  |             
      Lens, Cataract                       |                                                       3                  |             
      Retina, Degeneration                 |                                                                          |             
      Sclera, Mineralization, Focal        |                                                       3                  |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |             +                                                            |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |       +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +|             
      Calculus Micro Observation Only      |                                                                          |             
      Mineralization, Multifocal           |                                                                2         |             
      Nephropathy                          |       3  3  2        1  4  2  2  2  4  4  2  2  3  3  2  3     1     4  3|             
      Cortex, Cyst                         |                         1                                                |             
      Medulla, Inflammation, Multifocal    |                                                                3         |             
      Pelvis, Calculus Gross Observation   |                                                                          |             
      Pelvis, Inflammation, Acute          |                                                                          |             
      Pelvis, Transitional Epithelium,     |                                                                          |             
           Hyperplasia                     |                                                                          |             
      Renal Tubule, Epithelium,            |                                                                          |             
          Pigmentation                     |                            3                                             |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |       +  +  +        +  +  +  +  +  +  +  +  +  +  +  +  +     +     +  +|             
      Inflammation, Acute                  |                                                                3         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  50                                                               
NTP Experiment-Test: 05705-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 11:37:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 1| 7| 6| 6| 1| 4| 7| 7| 7| 1| 1| 5| 7| 6| 7| 7| 7| 7| 7| 1| 7| 7| 7| 7|             
                             DAY ON TEST   | 8| 8| 2| 5| 9| 8| 5| 1| 1| 3| 8| 8| 3| 3| 2| 3| 3| 2| 2| 3| 8| 2| 2| 3| 3|             
                                           | 3| 3| 9| 6| 1| 3| 6| 4| 5| 1| 3| 3| 8| 2| 1| 1| 2| 9| 9| 1| 3| 9| 9| 1| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    CONTROL                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |       +  +  +        +  +  +        +  +  +  +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         |       +  +  +        +  +  +        +  +  +  +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |       +  +  +        +  +  +        +  +  +  +  +  +  +  +     +  +  +  +|             
      Inflammation, Acute                  |                                                                          |             
      Parasite Metazoan                    |                                     X                                    |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |       +  +  +        +  +  +        +  +  +  +  +  +  +  +     +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |                                                                          |             
      Parasite Metazoan                    |                            X        X                 X                  |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |       +  +  +        +  +  +        +  +  +  +  +  +  +  +     +  +  +  +|             
      Inflammation, Acute                  |                                                                          |             
      Parasite Metazoan                    |                                           X                       X      |             
                                            __________________________________________________________________________|             
   Intestine Small                         |       +  +  +        +  +  +        +  +  +  +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |       +  +  +        +  +  +        +  +  M  +  +  +  +  +     +  +  +  +|             
      Autolysis                            |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |       +  +  +        +  +  +        +  +  +  +  +  +  +  +     +  +  +  +|             
      Autolysis                            |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |       +  +  +        +  +  +        +  +  +  +  +  +  +  +     +  +  +  +|             
      Autolysis                            |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   |       +  +  +        +  +  +        +  +  +  +  +  +  +  +     +  +  +  +|             
      Angiectasis, Focal                   |                                                                          |             
      Angiectasis                          |                                                                          |             
      Basophilic Focus                     |       X  X                 X                                         X   |             
      Basophilic Focus, Multiple           |                                                                          |             
      Congestion                           |                         2                                                |             
      Cytoplasmic Alteration, Focal        |                            2        2        2                 2         |             
      Cytoplasmic Alteration, Multifocal   |       2                                                                  |             
      Fatty Change, Diffuse                |                                                                          |             
      Fatty Change, Multifocal             |                                                                          |             
      Inflammation, Granulomatous,         |                                                                          |             
          Multifocal                       |                                                                          |             
      Necrosis, Acute, Focal               |                         2                                                |             
      Pigmentation, Diffuse                |                                                                          |             
      Thrombosis                           |                                                                          |             
      Vacuolization Cytoplasmic, Focal     |                                                 1                        |             
      Artery, Thrombosis                   |                                              2                           |             
      Bile Duct, Hyperplasia               |          1                          1     2     2  1                     |             
      Hepatocyte, Degeneration, Cystic,    |                                                                          |             
           Focal                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |          +                                                               |             
      Fat, Necrosis, Chronic, Multifocal   |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |       +  +  +        +  +  +        +  +  +  +  +  +  +  +     +  +  +  +|             
      Atrophy, Focal                       |                                        1        1     1  2     1     1   |             
      Cytoplasmic Alteration, Focal        |                                                                          |             
      Artery, Inflammation, Chronic        |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  51                                                               
NTP Experiment-Test: 05705-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 11:37:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 1| 7| 6| 6| 1| 4| 7| 7| 7| 1| 1| 5| 7| 6| 7| 7| 7| 7| 7| 1| 7| 7| 7| 7|             
                             DAY ON TEST   | 8| 8| 2| 5| 9| 8| 5| 1| 1| 3| 8| 8| 3| 3| 2| 3| 3| 2| 2| 3| 8| 2| 2| 3| 3|             
                                           | 3| 3| 9| 6| 1| 3| 6| 4| 5| 1| 3| 3| 8| 2| 1| 1| 2| 9| 9| 1| 3| 9| 9| 1| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    CONTROL                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |       +  +  +        +  M  +        +  +  +  +  +  +  +  +     +  +  +  +|             
      Atrophy, Diffuse                     |                                                                          |             
      Duct, Ectasia, Focal                 |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 |       +  +  +        +  +  +        +  +  +  +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |       +  +  +        +  +  +        +  +  +  +  +  +  +  +     +  +  +  +|             
      Hyperplasia                          |                         1                                                |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Necrosis, Focal                      |                                                                          |             
      Epithelium, Hyperplasia              |                      2                                                   |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |       +  +  +        +  +  +        +  +  +  +  +  +  +  +     +  +  +  +|             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Mineralization                       |                                                                          |             
      Necrosis, Focal                      |                         2                                                |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |       +  +  +        +  +  +        +  +  +  +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Heart                                   |       +  +  +        +  +  +        +  +  +  +  +  +  M  +     +  +  +  +|             
      Fibrosis, Focal                      |                                                                          |             
      Inflammation, Chronic                |       1  3  1        1  3  2        3  2  2     1  1     1     1  1  2  2|             
      Mineralization                       |                                                 1                        |             
      Artery, Mineralization, Multifocal   |                                                                          |             
      Atrium Left, Thrombosis              |                         1           4                                    |             
      Valve, Thrombosis                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |       +  +  +        +  +  +        +  +  +  +  +  +  +  +     +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |       +  +  +        +  +  +           +  +  +  +  +  +  +     +  +  +  +|             
      Hyperplasia, Focal                   |                                        1                       2         |             
      Hypertrophy, Focal                   |                                           2     2     1                  |             
      Necrosis, Focal                      |                                                                          |             
      Vacuolization Cytoplasmic, Diffuse   |                                                                          |             
      Vacuolization Cytoplasmic, Focal     |          2                                                           1   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |       +  +  M        +  +  +           +  +  +  +  +  +  +     +  +  +  +|             
      Hyperplasia, Focal                   |          2                             1  2     2        2              2|             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |       +  +  +        +  +  +        +  +  +  +  +  +  +  +     +  +  +  +|             
      Hyperplasia, Focal                   |                                                                          |             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |       +  +  +        +  +  +        +  +  +  +  M  +  +  +     +  +  M  +|             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |       +  +  +        +  +  +        +  +  +  +  +  +  +  +     +  +  +  +|             
      Pars Distalis, Angiectasis           |                                                                          |             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hyperplasia           |                      2                                         2         |             
      Pars Nervosa, Hyperplasia            |                            1                                             |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  52                                                               
NTP Experiment-Test: 05705-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 11:37:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 1| 7| 6| 6| 1| 4| 7| 7| 7| 1| 1| 5| 7| 6| 7| 7| 7| 7| 7| 1| 7| 7| 7| 7|             
                             DAY ON TEST   | 8| 8| 2| 5| 9| 8| 5| 1| 1| 3| 8| 8| 3| 3| 2| 3| 3| 2| 2| 3| 8| 2| 2| 3| 3|             
                                           | 3| 3| 9| 6| 1| 3| 6| 4| 5| 1| 3| 3| 8| 2| 1| 1| 2| 9| 9| 1| 3| 9| 9| 1| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    CONTROL                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |       +  +  +        +  +  +        +  +  +  +  +  +  +  +     +  +  +  +|             
      Ultimobranchial Cyst                 |                                                                      X   |             
      C-Cell, Hyperplasia                  |                                        1     1                    1      |             
      Follicular Cell, Hyperplasia         |                         1                                                |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |       +  +  +        +  +  +        +  +  +  +  +  +  +  +     +  +  +  +|             
      Duct, Epithelium, Degeneration       |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |       +  +  +        +  +  +        +  +  +  +  +  +  +  +     +  M  +  +|             
      Inflammation, Acute                  |          1                 2                 1           1              2|             
      Inflammation, Chronic                |       1     2                       1                 2        2         |             
      Duct, Hyperplasia, Squamous          |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                |       +  +  +        +  +  +        +  +  +  +  +  +  +  +     +  +  +  +|             
      Hyperplasia, Focal                   |       1                                         1                    1   |             
      Inflammation, Acute                  |                                           4                              |             
      Inflammation, Chronic                |                                              1                           |             
      Epithelium, Degeneration, Focal      |                                                                      1   |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |       M  M  M        M  M  M        +  M  M  M  M  M  M  M     M  M  M  M|             
                                            __________________________________________________________________________|             
   Testes                                  |       +  +  +        +  +  +        +  +  +  +  +  +  +  +     +  +  +  +|             
      Atrophy                              |                      4                                1                  |             
      Mineralization, Focal                |                                                                          |             
      Bilateral, Interstitial Cell,        |                                                                          |             
          Hyperplasia                      |                                                                          |             
      Interstitial Cell, Hyperplasia       |                                           2                              |             
      Seminiferous Tubule, Degeneration    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |       +  +  +        +  +  +        +  +  +  +  +  +  +  +     +  +  +  +|             
      Hyperplasia, Megakaryocyte           |                                                                          |             
      Hyperplasia                          |                                                                          |             
      Hypoplasia                           |                                                 2                        |             
      Myeloid Cell, Hyperplasia            |                                           2                              |             
                                            __________________________________________________________________________|             
   Lymph Node                              |       +  +  +        +  +  +        +  +  +  +  +  +  +  +     +  +  +  +|             
      Axillary, Congestion                 |                                                                          |             
      Iliac, Hyperplasia, Plasma Cell      |                                           3                              |             
      Iliac, Inflammation, Focal,          |                                                                          |             
          Granulomatous                    |                                           3                              |             
      Inguinal, Inflammation, Acute,       |                                                                          |             
          Multifocal                       |                                                                          |             
      Mediastinal, Congestion              |                                                                          |             
      Mediastinal, Hyperplasia             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  53                                                               
NTP Experiment-Test: 05705-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 11:37:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 1| 7| 6| 6| 1| 4| 7| 7| 7| 1| 1| 5| 7| 6| 7| 7| 7| 7| 7| 1| 7| 7| 7| 7|             
                             DAY ON TEST   | 8| 8| 2| 5| 9| 8| 5| 1| 1| 3| 8| 8| 3| 3| 2| 3| 3| 2| 2| 3| 8| 2| 2| 3| 3|             
                                           | 3| 3| 9| 6| 1| 3| 6| 4| 5| 1| 3| 3| 8| 2| 1| 1| 2| 9| 9| 1| 3| 9| 9| 1| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    CONTROL                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Pancreatic, Congestion               |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |       +  +  +        +  +  +        +  +  +  +  +  +  +  +     +  +  +  +|             
      Congestion                           |                                                                          |             
      Hyperplasia                          |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  |       +  +  +        +  +  +        +  +  +  +  +  +  +  +     +  +  +  +|             
      Fibrosis, Focal                      |                                                                          |             
      Fibrosis                             |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
          Granulocytic                     |                                           2                              |             
      Hemorrhage, Multifocal               |                                                                          |             
      Pigmentation, Diffuse                |                                                                          |             
      Capsule, Fibrosis, Focal             |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  |       I  I  +        +  +  +        +  +  +  +  +  +  +  +     +  I  +  +|             
      Cyst, Multiple                       |                                                                3         |             
      Hemorrhage                           |                                              1                           |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |       +  +  +        +  +  +        +  +  +  +  +  +  +  +     +  +  +  +|             
      Hyperplasia, Cystic                  |                                                                          |             
      Hyperplasia                          |                                                          2               |             
      Duct, Ectasia                        |                                        1                                 |             
                                            __________________________________________________________________________|             
   Skin                                    |       +  +  +        +  +  +        +  +  +  +  +  +  +  +     +  +  +  +|             
      Inflammation, Acute                  |                                           3                              |             
      Subcutaneous Tissue, Inflammation,   |                                                                          |             
           Acute                           |                                                                          |             
      Subcutaneous Tissue, Necrosis        |                      3                                                   |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |       +  +  +        +  +  +        +  +  +  +  +  +  +  +     +  +  +  +|             
      Fibrous Osteodystrophy               |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |       +  +  +        +  +  +        +  +  +  +  +  +  +  +     +  +  +  +|             
      Congestion                           |                         1                                                |             
      Hemorrhage, Focal                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |       +  +  +        +  +  +        +  +  +  +  +  +  +  +     +  +  +  +|             
      Congestion                           |                         2                                                |             
      Inflammation, Acute, Focal           |                                                                          |             
      Inflammation, Chronic                |                                                                   1      |             
      Inflammation, Focal, Granulomatous   |                                              1                           |             
      Mineralization, Focal                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  54                                                               
NTP Experiment-Test: 05705-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 11:37:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 1| 7| 6| 6| 1| 4| 7| 7| 7| 1| 1| 5| 7| 6| 7| 7| 7| 7| 7| 1| 7| 7| 7| 7|             
                             DAY ON TEST   | 8| 8| 2| 5| 9| 8| 5| 1| 1| 3| 8| 8| 3| 3| 2| 3| 3| 2| 2| 3| 8| 2| 2| 3| 3|             
                                           | 3| 3| 9| 6| 1| 3| 6| 4| 5| 1| 3| 3| 8| 2| 1| 1| 2| 9| 9| 1| 3| 9| 9| 1| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
    CONTROL                                | 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|             
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                                                                          |             
      Perivascular, Inflammation, Chronic  |                                                 1                        |             
                                            __________________________________________________________________________|             
   Nose                                    |       +  +  +        +  +  +        +  +  +  +  +  +  +  +     +  M  +  +|             
      Cyst                                 |                         4                    X                           |             
      Fungus                               |                            X                       X  X                 X|             
      Mucosa, Concretion, Focal            |                                                                          |             
      Mucosa, Inflammation, Acute          |          3           1  2                                                |             
      Mucosa, Inflammation, Chronic Active |                            3                       2  3                 3|             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Acute                           |                                                          1               |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Chronic                         |             2                                                            |             
      Respiratory Epithelium, Hyperplasia  |                                                    2                     |             
                                            __________________________________________________________________________|             
   Trachea                                 |       +  +  +        +  +  +        +  +  +  +  +  +  +  +     +  +  +  +|             
      Inflammation, Chronic                |                                                                      1   |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Ear                                     |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                    +                     |             
      Lens, Cataract                       |                                                    2                     |             
      Retina, Degeneration                 |                                                    3                     |             
      Sclera, Mineralization, Focal        |                                                    2                     |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |       +  +  +        +  +  +        +  +  +  +  +  +  +  +     +  +  +  +|             
      Calculus Micro Observation Only      |                                           X                              |             
      Mineralization, Multifocal           |                                                                          |             
      Nephropathy                          |       3  4  1        2  3  2        1  3  3  2  3  3  2  2     3  3  3  3|             
      Cortex, Cyst                         |                                                                          |             
      Medulla, Inflammation, Multifocal    |                                                                          |             
      Pelvis, Calculus Gross Observation   |                                           X                              |             
      Pelvis, Inflammation, Acute          |                                           2                              |             
      Pelvis, Transitional Epithelium,     |                                                                          |             
           Hyperplasia                     |                                           3                              |             
      Renal Tubule, Epithelium,            |                                                                          |             
          Pigmentation                     |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |       +  +  +        +  +  +        +  +  +  +  +  +  +  +     +  +  +  +|             
      Inflammation, Acute                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  55                                                               
NTP Experiment-Test: 05705-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 11:37:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 7| 7| 1| 5| 5| 7| 6| 4| 6| 6| 7| 5| 4| 4| 7| 6| 7|              |            |
                             DAY ON TEST   | 5| 3| 3| 3| 2| 8| 0| 7| 3| 2| 5| 3| 9| 2| 8| 3| 5| 3| 7| 3|              |            |
                                           | 6| 0| 1| 0| 8| 3| 6| 5| 0| 9| 6| 1| 1| 5| 4| 6| 6| 0| 9| 0|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |      A     |
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |      L     |
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |    +  +  +  +     +  +  +  +     +  +  +  +  +     +  +  +               |  53        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |    +  +  +  +     +  +  +  +     +  +  +  +  +     +  +  +               |  53        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |    +  +  +  +     +  +  +  A     +  +  +  +  +     +  +  +               |  52        |
      Inflammation, Acute                  |             1        1                                                   |      2  1.0|
      Parasite Metazoan                    |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |    +  +  +  +     +  +  +  +     +  +  +  +  +     +  +  +               |  53        |
      Infiltration Cellular, Lymphocyte    |                                                                          |      1  2.0|
      Parasite Metazoan                    |    X              X                 X                                    |     11     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |    +  +  +  +     +  +  +  +     +  +  +  +  +     +  +  +               |  53        |
      Inflammation, Acute                  |                                  2                                       |      1  2.0|
      Parasite Metazoan                    |                                                                          |      5     |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |    +  +  +  +     +  +  +  +     +  +  +  +  +     +  +  +               |  53        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |    +  +  +  +     +  +  +  +     +  +  +  +  +     +  +  +               |  52        |
      Autolysis                            |                   2                                                      |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |    +  +  +  +     +  +  +  +     +  +  +  +  +     +  +  +               |  53        |
      Autolysis                            |                   2                                                      |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |    +  +  +  +     +  +  +  A     +  +  +  +  +     +  +  +               |  51        |
      Autolysis                            |                   2                                                      |      1  2.0|
                                            __________________________________________________________________________|____________|
   Liver                                   |    +  +  +  +     +  +  +  +     +  +  +  +  +     +  +  +               |  53        |
      Angiectasis, Focal                   |                                     2                                    |      1  2.0|
      Angiectasis                          |                         3                                                |      1  3.0|
      Basophilic Focus                     |       X  X                                                               |      9  2.0|
      Basophilic Focus, Multiple           |    X                                                     X               |      3     |
      Congestion                           |                                                                          |      1  2.0|
      Cytoplasmic Alteration, Focal        |                                                                          |      9  2.2|
      Cytoplasmic Alteration, Multifocal   |                                                                          |      2  2.0|
      Fatty Change, Diffuse                |                                                                          |      1  2.0|
      Fatty Change, Multifocal             |                      3                                                   |      1  3.0|
      Inflammation, Granulomatous,         |                                                                          |            |
          Multifocal                       |                                                                          |      1  2.0|
      Necrosis, Acute, Focal               |          1                                                               |      2  1.5|
      Pigmentation, Diffuse                |                                           2                              |      1  2.0|
      Thrombosis                           |                                                                          |      1  2.0|
      Vacuolization Cytoplasmic, Focal     |                                                                          |      1  1.0|
      Artery, Thrombosis                   |                                                                          |      1  2.0|
      Bile Duct, Hyperplasia               |       1              3     2     2  3     3                              |     20  2.0|
      Hepatocyte, Degeneration, Cystic,    |                                                                          |            |
           Focal                           |                         2           2                                    |      5  1.8|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                      +                                                   |   2        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  56                                                               
NTP Experiment-Test: 05705-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 11:37:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 7| 7| 1| 5| 5| 7| 6| 4| 6| 6| 7| 5| 4| 4| 7| 6| 7|              |            |
                             DAY ON TEST   | 5| 3| 3| 3| 2| 8| 0| 7| 3| 2| 5| 3| 9| 2| 8| 3| 5| 3| 7| 3|              |            |
                                           | 6| 0| 1| 0| 8| 3| 6| 5| 0| 9| 6| 1| 1| 5| 4| 6| 6| 0| 9| 0|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |      A     |
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |      L     |
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Fat, Necrosis, Chronic, Multifocal   |                      3                                                   |      1  3.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                |    +  +  +  +     +  +  +  +     +  +  M  +  +     +  +  +               |  52        |
      Atrophy, Focal                       |                         2        2        2        2  1                  |     16  1.4|
      Cytoplasmic Alteration, Focal        |                                                                          |      1  1.0|
      Artery, Inflammation, Chronic        |       2                                                                  |      1  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |    +  +  +  +     +  +  +  +     +  +  +  +  +     +  +  +               |  52        |
      Atrophy, Diffuse                     |                                                                          |      1  1.0|
      Duct, Ectasia, Focal                 |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 |    +  +  +  +     +  +  +  +     +  +  +  +  +     +  +  +               |  53        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |    +  +  +  +     +  +  +  +     +  +  +  +  +     +  +  +               |  53        |
      Hyperplasia                          |                                                                          |      1  1.0|
      Inflammation, Acute                  |                                     2                 3                  |      3  2.3|
      Inflammation, Chronic                |             2                                                            |      2  2.5|
      Necrosis, Focal                      |                                     2                                    |      1  2.0|
      Epithelium, Hyperplasia              |                                     3                                    |      2  2.5|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |    +  +  +  +     +  +  +  +     +  +  +  +  +     +     +               |  52        |
      Inflammation, Acute                  |                                                                          |      1  2.0|
      Inflammation, Chronic                |                                              2                           |      1  2.0|
      Mineralization                       |                                                                          |      1  2.0|
      Necrosis, Focal                      |             2                                                            |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |    +  +  +  +     +  +  +  +     +  +  +  +  +     +  +  +               |  53        |
                                            __________________________________________________________________________|____________|
   Heart                                   |    +  +  +  +     +  +  +  +     +  +  +  +  +     +  +  +               |  52        |
      Fibrosis, Focal                      |                                                                          |      2  3.0|
      Inflammation, Chronic                |    2  1  2  2     3  2  2  2     3  2  2  2  2        2  2               |     48  1.9|
      Mineralization                       |                                  2                                       |      2  1.5|
      Artery, Mineralization, Multifocal   |                                                                          |      1  2.0|
      Atrium Left, Thrombosis              |                                        3  X                              |      5  3.0|
      Valve, Thrombosis                    |       1                                                                  |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |    +  +  +  +     +  +  +  +     +  +  +  +  +     +  +  +               |  53        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |    +  +  +  +     +  +  +  +     +  +  +  +  +     +  +  +               |  52        |
      Hyperplasia, Focal                   |       1                 2                          1     1               |      9  1.3|
      Hypertrophy, Focal                   |                                        2                                 |      5  1.6|
      Necrosis, Focal                      |                                                                          |      1  1.0|
      Vacuolization Cytoplasmic, Diffuse   |                      2                       2                           |      2  2.0|
      Vacuolization Cytoplasmic, Focal     |             2                       2                 3                  |      7  1.7|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  57                                                               
NTP Experiment-Test: 05705-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 11:37:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 7| 7| 1| 5| 5| 7| 6| 4| 6| 6| 7| 5| 4| 4| 7| 6| 7|              |            |
                             DAY ON TEST   | 5| 3| 3| 3| 2| 8| 0| 7| 3| 2| 5| 3| 9| 2| 8| 3| 5| 3| 7| 3|              |            |
                                           | 6| 0| 1| 0| 8| 3| 6| 5| 0| 9| 6| 1| 1| 5| 4| 6| 6| 0| 9| 0|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |      A     |
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |      L     |
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |    +  +  +  +     +  +  +  +     +  +  +  +  +     +  +  +               |  51        |
      Hyperplasia, Focal                   |                                                    1  2                  |     10  1.8|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |    +  +  +  +     +  +  +  +     +  +  M  +  +     +  +  +               |  52        |
      Hyperplasia, Focal                   |                                                       3                  |      1  3.0|
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |    +  +  M  +     +  +  +  +     +  +  +  M  +     +  M  +               |  48        |
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |    +  +  +  +     +  +  +  +     +  +  +  +  +     +  +  +               |  53        |
      Pars Distalis, Angiectasis           |                                                                          |      1  1.0|
      Pars Distalis, Cyst                  |                                  X                                       |      2  2.0|
      Pars Distalis, Hyperplasia           |                   2     2                                                |      8  1.8|
      Pars Nervosa, Hyperplasia            |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |    +  +  +  +     +  +  +  +     +  +  +  +  +     +  +  +               |  53        |
      Ultimobranchial Cyst                 |                                                                          |      1     |
      C-Cell, Hyperplasia                  |          2  1           1           1  1                                 |     11  1.4|
      Follicular Cell, Hyperplasia         |                                                                          |      3  1.0|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              |    +  +  +  +     +  +  +  +     +  +  +  +  M     +  +  +               |  52        |
      Duct, Epithelium, Degeneration       |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |    +  +  +  +     +  +  +  +     +  +  +  +  +     +  +  +               |  51        |
      Inflammation, Acute                  |       1     1                                                            |     10  1.3|
      Inflammation, Chronic                |       1              2              2     2        1     1               |     18  1.6|
      Duct, Hyperplasia, Squamous          |          3                                                               |      1  3.0|
                                            __________________________________________________________________________|____________|
   Prostate                                |    +  I  +  M     +  +  +  +     +  +  +  +  +     +  +  +               |  48        |
      Hyperplasia, Focal                   |                                                                          |      4  1.0|
      Inflammation, Acute                  |                                                    4                     |      6  2.7|
      Inflammation, Chronic                |                                                                          |      1  1.0|
      Epithelium, Degeneration, Focal      |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |    M  M  M  M     M  M  M  M     M  M  M  M  M     M  M  M               |   1        |
                                            __________________________________________________________________________|____________|
   Testes                                  |    +  +  +  +     +  +  +  +     +  +  +  +  +     +  +  +               |  53        |
      Atrophy                              |          3                                                               |      6  2.7|
      Mineralization, Focal                |                                                                          |      1  1.0|
      Bilateral, Interstitial Cell,        |                                                                          |            |
          Hyperplasia                      |                                                       2                  |      1  2.0|
      Interstitial Cell, Hyperplasia       |                                           1                              |      6  1.5|
      Seminiferous Tubule, Degeneration    |                                           3                              |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  58                                                               
NTP Experiment-Test: 05705-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 11:37:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 7| 7| 1| 5| 5| 7| 6| 4| 6| 6| 7| 5| 4| 4| 7| 6| 7|              |            |
                             DAY ON TEST   | 5| 3| 3| 3| 2| 8| 0| 7| 3| 2| 5| 3| 9| 2| 8| 3| 5| 3| 7| 3|              |            |
                                           | 6| 0| 1| 0| 8| 3| 6| 5| 0| 9| 6| 1| 1| 5| 4| 6| 6| 0| 9| 0|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |      A     |
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |      L     |
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |    +  +  +  +     +  +  +  +     +  +  +  +  +     +  +  +               |  53        |
      Hyperplasia, Megakaryocyte           |                                                                          |      1  3.0|
      Hyperplasia                          |                                           2                              |      2  2.0|
      Hypoplasia                           |                                                       2                  |      2  2.0|
      Myeloid Cell, Hyperplasia            |                            2                                             |      2  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |    +  +  +  +     +  +  +  +     +  +  +  +  +     +  +  +               |  53        |
      Axillary, Congestion                 |                                        2                                 |      1  2.0|
      Iliac, Hyperplasia, Plasma Cell      |                                                                          |      1  3.0|
      Iliac, Inflammation, Focal,          |                                                                          |            |
          Granulomatous                    |                                                                          |      1  3.0|
      Inguinal, Inflammation, Acute,       |                                                                          |            |
          Multifocal                       |                                                                          |      1  2.0|
      Mediastinal, Congestion              |             2        2                 2                                 |      5  2.0|
      Mediastinal, Hyperplasia             |                      2                                                   |      1  2.0|
      Pancreatic, Congestion               |                                        2                                 |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |    +  +  +  +     +  +  +  +     +  +  +  +  +     +  +  +               |  53        |
      Congestion                           |                                        2                                 |      1  2.0|
      Hyperplasia                          |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  |    +  +  +  +     +  +  +  +     +  +  +  +  +     +  +  +               |  53        |
      Fibrosis, Focal                      |                         2                                                |      1  2.0|
      Fibrosis                             |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     |                                                                          |            |
          Granulocytic                     |                            2                                             |      2  2.0|
      Hemorrhage, Multifocal               |                   3                                                      |      1  3.0|
      Pigmentation, Diffuse                |                                                                          |      1  2.0|
      Capsule, Fibrosis, Focal             |             2     2                                                      |      2  2.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  |    +  +  +  +     +  +  +  +     +  +  +  +  +     +  I  +               |  47        |
      Cyst, Multiple                       |                                                                          |      1  3.0|
      Hemorrhage                           |                                                                          |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |    +  +  +  +     +  +  +  +     +  +  +  +  +     +  +  +               |  53        |
      Hyperplasia, Cystic                  |                                           2                              |      1  2.0|
      Hyperplasia                          |                                     1                                    |      2  1.5|
      Duct, Ectasia                        |             2                                                            |      2  1.5|
                                            __________________________________________________________________________|____________|
   Skin                                    |    +  +  +  +     +  +  +  +     +  +  +  +  +     +  +  +               |  53        |
      Inflammation, Acute                  |                                                                          |      1  3.0|
      Subcutaneous Tissue, Inflammation,   |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  59                                                               
NTP Experiment-Test: 05705-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 11:37:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 7| 7| 1| 5| 5| 7| 6| 4| 6| 6| 7| 5| 4| 4| 7| 6| 7|              |            |
                             DAY ON TEST   | 5| 3| 3| 3| 2| 8| 0| 7| 3| 2| 5| 3| 9| 2| 8| 3| 5| 3| 7| 3|              |            |
                                           | 6| 0| 1| 0| 8| 3| 6| 5| 0| 9| 6| 1| 1| 5| 4| 6| 6| 0| 9| 0|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |      A     |
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |      L     |
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
           Acute                           |                            3                                             |      1  3.0|
      Subcutaneous Tissue, Necrosis        |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |    +  +  +  +     +  +  +  +     +  +  +  +  +     +  +  +               |  53        |
      Fibrous Osteodystrophy               |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                  +                                       |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |    +  +  +  +     +  +  +  +     +  +  +  +  +     +  +  +               |  53        |
      Congestion                           |                                                                          |      1  1.0|
      Hemorrhage, Focal                    |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |    +  +  +  +     +  +  +  +     +  +  +  +  +     +  +  +               |  53        |
      Congestion                           |                                                                          |      2  2.0|
      Inflammation, Acute, Focal           |             2                                                            |      2  2.0|
      Inflammation, Chronic                |                                                          1               |      3  1.7|
      Inflammation, Focal, Granulomatous   |                                                       2                  |      4  1.8|
      Mineralization, Focal                |                                           2                              |      1  2.0|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |                                     1                                    |      2  1.0|
      Perivascular, Inflammation, Chronic  |          1                                                               |      4  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    |    +  +  +  +     +  +  +  +     +  +  +  +  +     +  +  +               |  52        |
      Cyst                                 |                                                                          |      3  2.5|
      Fungus                               |       X                             X              X                     |      8     |
      Mucosa, Concretion, Focal            |                                                       2                  |      1  2.0|
      Mucosa, Inflammation, Acute          |       3  2                                                               |      7  2.3|
      Mucosa, Inflammation, Chronic Active |                                     3              3                     |      9  2.6|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Acute                           |                                                                          |      3  1.7|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Chronic                         |                                                                          |      1  2.0|
      Respiratory Epithelium, Hyperplasia  |       2                                                                  |      2  2.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 |    +  +  +  +     +  +  +  +     +  +  +  +  +     +  +  +               |  53        |
      Inflammation, Chronic                |       1                                                                  |      2  1.0|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Ear                                     |                      +                                                   |   1        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  60                                                               
NTP Experiment-Test: 05705-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 11:37:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 7| 7| 1| 5| 5| 7| 6| 4| 6| 6| 7| 5| 4| 4| 7| 6| 7|              |            |
                             DAY ON TEST   | 5| 3| 3| 3| 2| 8| 0| 7| 3| 2| 5| 3| 9| 2| 8| 3| 5| 3| 7| 3|              |            |
                                           | 6| 0| 1| 0| 8| 3| 6| 5| 0| 9| 6| 1| 1| 5| 4| 6| 6| 0| 9| 0|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1| 1|              |      A     |
    CONTROL                                | 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4|              |      L     |
    MALE                                   | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                           +                              |   4        |
      Lens, Cataract                       |                                                                          |      2  2.5|
      Retina, Degeneration                 |                                                                          |      1  3.0|
      Sclera, Mineralization, Focal        |                                           2                              |      3  2.3|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |    +  +  +  +     +  +  +  +     +  +  +  +  +     +  +  +               |  53        |
      Calculus Micro Observation Only      |                                                                          |      1     |
      Mineralization, Multifocal           |                                                                          |      1  2.0|
      Nephropathy                          |    3  3  3  3     3  2  3  2     3  3  3  2  3     4  4  3               |     53  2.7|
      Cortex, Cyst                         |                                                                          |      1  1.0|
      Medulla, Inflammation, Multifocal    |                                                                          |      1  3.0|
      Pelvis, Calculus Gross Observation   |                                                                          |      1     |
      Pelvis, Inflammation, Acute          |                                                    1                     |      2  1.5|
      Pelvis, Transitional Epithelium,     |                                                                          |            |
           Hyperplasia                     |                                                    2                     |      2  2.5|
      Renal Tubule, Epithelium,            |                                                                          |            |
          Pigmentation                     |                                        3  3                              |      3  3.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |    +  +  +  M     +  +  +  +     M  +  +  +  +     +  +  +               |  51        |
      Inflammation, Acute                  |                                                    2                     |      2  2.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  61                                                               
NTP Experiment-Test: 05705-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 11:37:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 4| 5| 7| 7| 1| 1| 5| 6| 7| 4| 4| 7| 7| 7| 4| 7| 6| 6| 7| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 6| 5| 5| 2| 3| 8| 8| 6| 4| 3| 4| 5| 0| 3| 3| 5| 3| 3| 8| 1| 0| 3| 2| 3| 3|             
                                           | 4| 6| 7| 9| 2| 3| 3| 9| 4| 1| 8| 6| 6| 2| 0| 6| 0| 3| 6| 8| 6| 2| 5| 2| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    15 MG/KG                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
     MALE                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               | +     +  +  +        +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         | +     +  +  +        +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  | +     +  +  +        +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Inflammation, Acute                  |                                     2                                    |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  | +     +  +  +        +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Lymphoid                |                                                                          |             
      Parasite Metazoan                    |                      X     X                                X            |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 | +     +  +  +        +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         | +     +  +  +        +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               | +     +  +  +        +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  | +     +  +  +        +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                       3                  |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                | +     +  +  +        +  +  +  M     +  +  +     +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                       2                  |             
                                            __________________________________________________________________________|             
   Liver                                   | +     +  +  +        +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
      Angiectasis, Focal                   |                                                                          |             
      Basophilic Focus                     |                                                                          |             
      Basophilic Focus, Multiple           |          X  X              X              X                    X        X|             
      Clear Cell Focus                     |                                                                          |             
      Congestion                           |                                                                          |             
      Cytoplasmic Alteration, Focal        |                                        2  2                              |             
      Hepatodiaphragmatic Nodule           |                                                                          |             
      Hyperplasia, Focal                   |                                                                          |             
      Inflammation, Chronic                | 1                                                                        |             
      Inflammation, Granulomatous,         |                                                                          |             
          Multifocal                       |             1                             1                              |             
      Necrosis, Acute, Focal               |                                                                          |             
      Thrombosis                           |                                                                          |             
      Vacuolization Cytoplasmic, Focal     |                                                                          |             
      Bile Duct, Hyperplasia               |             2        2  1  1                             3     2        1|             
      Centrilobular, Fatty Change          |                                                                          |             
      Centrilobular, Vacuolization         |                                                                          |             
          Cytoplasmic                      |                                                          3               |             
      Hepatocyte, Degeneration, Cystic,    |                                                                          |             
           Focal                           |                                                       2                  |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Fat, Necrosis, Focal                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                | +     +  +  +        +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
      Atrophy, Focal                       |       1  1                                1     1     2  1  2     2  1  1|             
      Congestion, Focal                    |                                                                          |             
      Hyperplasia, Focal                   |                      3                                                   |             
      Inflammation, Chronic                |                                                                          |             
      Artery, Mineralization               |                            2                                             |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  62                                                               
NTP Experiment-Test: 05705-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 11:37:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 4| 5| 7| 7| 1| 1| 5| 6| 7| 4| 4| 7| 7| 7| 4| 7| 6| 6| 7| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 6| 5| 5| 2| 3| 8| 8| 6| 4| 3| 4| 5| 0| 3| 3| 5| 3| 3| 8| 1| 0| 3| 2| 3| 3|             
                                           | 4| 6| 7| 9| 2| 3| 3| 9| 4| 1| 8| 6| 6| 2| 0| 6| 0| 3| 6| 8| 6| 2| 5| 2| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    15 MG/KG                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
     MALE                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Duct, Ectasia, Focal                 |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         | +     +  +  +        +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute, Focal           |                                        1                                 |             
      Inflammation, Chronic                | 2                                                                        |             
      Duct, Inflammation, Acute            |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 | +     +  +  +        +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    | +     +  +  +        +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  | 2                                   1                                    |             
      Inflammation, Chronic Active         |                         3                                                |             
      Mineralization                       |                            3                                             |             
      Epithelium, Hyperplasia              |                                                 1                        |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      | +     +  +  +        +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
      Infiltration Cellular, Lymphocyte    |                      2                 2                                 |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |                         1                                                |             
      Inflammation, Chronic Active         |                                                                          |             
      Mineralization                       |                            4                                             |             
      Necrosis, Focal                      |                                     1              1     2               |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            | +     +  +  +        +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                                                                          |             
      Aorta, Mineralization                |                            3                                             |             
                                            __________________________________________________________________________|             
   Heart                                   | +     +  +  +        +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
      Inflammation, Chronic                |          3  2        2  2  2  2     1  2  3     1     2  2  2  1  1  2  1|             
      Mineralization                       |                            3                                             |             
      Atrium Left, Thrombosis              |                                                    X     3        3      |             
      Valve, Thrombosis                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           | +     +  +  +        +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   | +     +  +  +        +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hyperplasia, Focal                   |             1                             1                          2  1|             
      Hyperplasia                          |                                     3                                    |             
      Hypertrophy, Focal                   |             1                          1                 1               |             
      Necrosis, Focal                      |                                                                          |             
      Vacuolization Cytoplasmic, Focal     |          1           1  2                                            1   |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  | +     +  +  +        +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                     1                                    |             
      Thrombosis                           |                                                                          |             
      Bilateral, Hyperplasia, Focal        |                            2                                             |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      | +     +  +  +        +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       | M     +  +  +        +  +  +  +     +  +  M     +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  63                                                               
NTP Experiment-Test: 05705-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 11:37:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 4| 5| 7| 7| 1| 1| 5| 6| 7| 4| 4| 7| 7| 7| 4| 7| 6| 6| 7| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 6| 5| 5| 2| 3| 8| 8| 6| 4| 3| 4| 5| 0| 3| 3| 5| 3| 3| 8| 1| 0| 3| 2| 3| 3|             
                                           | 4| 6| 7| 9| 2| 3| 3| 9| 4| 1| 8| 6| 6| 2| 0| 6| 0| 3| 6| 8| 6| 2| 5| 2| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    15 MG/KG                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
     MALE                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Hyperplasia, Focal                   |                                     1                                    |             
      Hyperplasia                          |                         2  2                                             |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         | +     +  +  +        +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Pars Distalis, Angiectasis           |                                                                          |             
      Pars Distalis, Cyst                  |                      1                                                   |             
      Pars Distalis, Hyperplasia           |          1           1              1                                    |             
      Pars Intermedia, Hyperplasia, Focal  |                                           2                              |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           | +     +  +  +        +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |          1                             2                                 |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                               +                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              | +     +  +  +        M  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         | +     +  +  +        +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
      Cyst                                 |                                                                          |             
      Hyperplasia                          |                                                                2         |             
      Inflammation, Acute                  |                         3  2           2           2           2         |             
      Inflammation, Chronic                |             1        1                    2           1  1           2   |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Prostate                                | +     +  +  +        +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                                                         3|             
      Inflammation, Chronic                |             1                                                        1   |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         | M     M  M  M        M  M  M  M     M  M  M     M  M  M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Testes                                  | +     +  +  +        +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
      Atrophy                              |             3           3                                2               |             
      Bilateral, Interstitial Cell,        |                                                                          |             
          Hyperplasia                      |                                                                          |             
      Interstitial Cell, Hyperplasia       |                                     1              1                     |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             | +     +  +  +        +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
      Hyperplasia                          |                                                    2                     |             
      Myelofibrosis                        |                                                             1            |             
      Myeloid Cell, Hyperplasia            |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              | +     +  +  +        +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
      Axillary, Hyperplasia                |                                                                          |             
      Inguinal, Infiltration Cellular,     |                                                                          |             
           Plasma Cell                     |                                                                          |             
      Mediastinal, Hemorrhage              |                                                                          |             
      Mediastinal, Hyperplasia             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  64                                                               
NTP Experiment-Test: 05705-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 11:37:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 4| 5| 7| 7| 1| 1| 5| 6| 7| 4| 4| 7| 7| 7| 4| 7| 6| 6| 7| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 6| 5| 5| 2| 3| 8| 8| 6| 4| 3| 4| 5| 0| 3| 3| 5| 3| 3| 8| 1| 0| 3| 2| 3| 3|             
                                           | 4| 6| 7| 9| 2| 3| 3| 9| 4| 1| 8| 6| 6| 2| 0| 6| 0| 3| 6| 8| 6| 2| 5| 2| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    15 MG/KG                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
     MALE                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Pancreatic, Inflammation, Chronic    |                                                                   4      |             
      Renal, Hemorrhage                    |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  | +     +  +  +        +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hemorrhage                           |                                                          1               |             
      Hyperplasia                          |                                                                          |             
      Necrosis, Focal                      |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  | +     +  +  +        +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                         2                                                |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
          Granulocytic                     |                                                                          |             
      Necrosis, Focal                      |                                                                   3      |             
                                            __________________________________________________________________________|             
   Thymus                                  | +     +  +  +        +  +  +  I     +  +  +     +  +  +  I  +  +  +  +  +|             
      Ectasia                              |                                                                          |             
      Hyperplasia                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           | +     +  +  +        +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
      Fibrosis                             |                                                                          |             
      Hyperplasia                          |                                        1                                 |             
      Mineralization                       |                                                                          |             
      Pigmentation                         |                                                                          |             
      Duct, Ectasia                        |          1                          1                       1           2|             
                                            __________________________________________________________________________|             
   Skin                                    | +     +  +  +        +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Subcutaneous Tissue, Edema           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    | +     +  +  +        +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
      Fibrous Osteodystrophy               |                         1  3                                             |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   | +     +  +  +        +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
      Hemorrhage, Focal                    |                                                                          |             
      Meninges, Vein, Cerebrum, Thrombosis |       X                                                                  |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    | +     +  +  +        +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
      Congestion                           |                      1                                                   |             
      Fibrosis, Multifocal                 |          1                                      1                        |             
      Hemorrhage, Focal                    |                            1                                             |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  65                                                               
NTP Experiment-Test: 05705-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 11:37:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 3| 4| 5| 7| 7| 1| 1| 5| 6| 7| 4| 4| 7| 7| 7| 4| 7| 6| 6| 7| 7| 7| 6| 7| 7|             
                             DAY ON TEST   | 6| 5| 5| 2| 3| 8| 8| 6| 4| 3| 4| 5| 0| 3| 3| 5| 3| 3| 8| 1| 0| 3| 2| 3| 3|             
                                           | 4| 6| 7| 9| 2| 3| 3| 9| 4| 1| 8| 6| 6| 2| 0| 6| 0| 3| 6| 8| 6| 2| 5| 2| 0|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    15 MG/KG                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2| 3| 3| 3| 3| 3|             
     MALE                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                         2                                                |             
      Alveolar Epithelium, Hyperplasia     |                                                             1            |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                            1                                   2         |             
      Alveolus, Pigmentation               |                                                                1         |             
      Artery, Media, Hypertrophy           |                                                                          |             
      Perivascular, Inflammation, Chronic  |                                           1                              |             
                                            __________________________________________________________________________|             
   Nose                                    | +     +  +  +        +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                                                                   2      |             
      Foreign Body                         |                                     2                                    |             
      Fungus                               |                      X                                                   |             
      Mucosa, Inflammation, Acute          |                                     2                    1               |             
      Mucosa, Inflammation, Chronic        |                                                                          |             
      Mucosa, Inflammation, Chronic Active |                      3                                                   |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Acute                           |                                                                          |             
      Respiratory Epithelium, Hyperplasia, |                                                                          |             
           Papillary                       |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 | +     +  +  +        +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                   +      |             
      Bilateral, Lens, Cataract            |                                                                   1      |             
      Lens, Cataract                       |                                                                          |             
      Sclera, Mineralization, Focal        |                                                                   2      |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  | +     +  +  +        +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
      Autolysis                            |                               3                                          |             
      Congestion                           |                                                                          |             
      Nephropathy                          | 1     1  3  2        2  4  4  1     3  3  3     3  2  3  3  3  3  2  3  3|             
      Cortex, Cyst                         |                                                                          |             
      Pelvis, Inflammation, Acute          |                                                                          |             
      Pelvis, Transitional Epithelium,     |                                                                          |             
           Hyperplasia                     |                         2                                                |             
      Renal Tubule, Epithelium,            |                                                                          |             
          Pigmentation                     |                                                    2                     |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         | +     +  +  +        +  +  +  +     +  +  +     +  +  +  +  +  +  +  +  +|             
      Hemorrhage                           |                         2                                                |             
      Transitional Epithelium, Hyperplasia |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  66                                                               
NTP Experiment-Test: 05705-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 11:37:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 5| 7| 7| 7| 1| 1| 5| 7| 7| 1| 7| 6| 7| 6| 1| 4| 4| 7| 7| 1| 1| 7| 7| 7|             
                             DAY ON TEST   | 5| 5| 1| 3| 3| 8| 8| 8| 2| 2| 8| 2| 1| 3| 8| 8| 5| 5| 2| 2| 8| 8| 3| 3| 3|             
                                           | 6| 6| 8| 0| 1| 3| 3| 8| 8| 5| 3| 9| 1| 0| 7| 3| 6| 6| 9| 9| 3| 3| 0| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    15 MG/KG                               | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
     MALE                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +  +  +  +        +  +  +     +  +  +  +           +  +        +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large                         |    +  +  +  +        +  +  +     +  +  +  +           +  +        +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    +  +  +  +        +  +  +     +  +  +  +           +  +        +  +  +|             
      Autolysis                            |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +  +  +  +        +  +  +     +  +  +  +           +  +        +  +  +|             
      Hyperplasia, Lymphoid                |                                                                      2   |             
      Parasite Metazoan                    |                         X                                         X      |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +  +  +  +        +  +  +     +  +  +  +           +  +        +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small                         |    +  +  +  +        +  +  +     +  +  +  +           +  +        +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +  +  +  +        +  +  +     +  +  +  +           +  +        +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    M  +  +  +        +  +  +     +  +  +  +           +  +        +  +  +|             
      Autolysis                            |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +  +  +  +        +  +  +     +  +  +  +           +  +        +  +  +|             
      Autolysis                            |                                                                          |             
                                            __________________________________________________________________________|             
   Liver                                   |    +  +  +  +        +  +  +     +  +  +  +           +  +        +  +  +|             
      Angiectasis, Focal                   |                                                                          |             
      Basophilic Focus                     |                      X                                                   |             
      Basophilic Focus, Multiple           |          X  X                    X     X                                 |             
      Clear Cell Focus                     |                                  X                                       |             
      Congestion                           |    2                 1                                                   |             
      Cytoplasmic Alteration, Focal        |             1                                                            |             
      Hepatodiaphragmatic Nodule           |                                  X                                   X   |             
      Hyperplasia, Focal                   |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Granulomatous,         |                                                                          |             
          Multifocal                       |                                                                          |             
      Necrosis, Acute, Focal               |                                                                          |             
      Thrombosis                           |                                                                          |             
      Vacuolization Cytoplasmic, Focal     |                         1                                                |             
      Bile Duct, Hyperplasia               |          2                             1                                 |             
      Centrilobular, Fatty Change          |                                                                          |             
      Centrilobular, Vacuolization         |                                                                          |             
          Cytoplasmic                      |                                                                          |             
      Hepatocyte, Degeneration, Cystic,    |                                                                          |             
           Focal                           |                                                          1               |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Fat, Necrosis, Focal                 |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +  +  +  +        +  +  +     +  +  +  +           +  +        +  +  +|             
      Atrophy, Focal                       |                                  1  1                                    |             
      Congestion, Focal                    |                                                                          |             
      Hyperplasia, Focal                   |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Artery, Mineralization               |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  67                                                               
NTP Experiment-Test: 05705-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 11:37:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 5| 7| 7| 7| 1| 1| 5| 7| 7| 1| 7| 6| 7| 6| 1| 4| 4| 7| 7| 1| 1| 7| 7| 7|             
                             DAY ON TEST   | 5| 5| 1| 3| 3| 8| 8| 8| 2| 2| 8| 2| 1| 3| 8| 8| 5| 5| 2| 2| 8| 8| 3| 3| 3|             
                                           | 6| 6| 8| 0| 1| 3| 3| 8| 8| 5| 3| 9| 1| 0| 7| 3| 6| 6| 9| 9| 3| 3| 0| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    15 MG/KG                               | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
     MALE                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Duct, Ectasia, Focal                 |                            1                                             |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +  +  +  +        +  +  +     +  +  +  +           +  +        +  +  +|             
      Inflammation, Acute, Focal           |                                  1                       1               |             
      Inflammation, Chronic                |                                                                          |             
      Duct, Inflammation, Acute            |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 |    +  +  +  +        +  +  +     +  +  +  +           +  +        +  +  +|             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +  +  +  +        +  +  +     +  +  +  +           +  +        +  +  +|             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Mineralization                       |                                                                          |             
      Epithelium, Hyperplasia              |                         3  1                             1               |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +  +  +  +        +  +  +     +  +  +  +           +  +        +  +  +|             
      Infiltration Cellular, Lymphocyte    |                                                                   1      |             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Mineralization                       |       2                 2                                                |             
      Necrosis, Focal                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |    +  +  +  +        +  +  +     +  +  +  +           +  +        +  +  +|             
      Inflammation, Acute                  |                                                                          |             
      Aorta, Mineralization                |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |    +  +  +  +        +  +  +     +  +  +  +           +  +        +  +  +|             
      Inflammation, Chronic                |    1  1  2  2        3  2  2     3  2  3  2           2  2        1  2   |             
      Mineralization                       |                         2                                                |             
      Atrium Left, Thrombosis              |                                                                          |             
      Valve, Thrombosis                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |    +  +  +  +        M  +  +     +  +  +  +           +  +        +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |    +  +  +  +        M  +  +     +  +  +  +           +  +        +  +  +|             
      Cyst                                 |                                                          1               |             
      Hyperplasia, Focal                   |                                                                      1   |             
      Hyperplasia                          |                                                                          |             
      Hypertrophy, Focal                   |                                  1                                       |             
      Necrosis, Focal                      |                                                                          |             
      Vacuolization Cytoplasmic, Focal     |       1     1           1                                         1      |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |    M  +  +  +        M  +  +     +  +  +  +           +  +        +  +  +|             
      Hyperplasia, Focal                   |             1              1                          2              1   |             
      Thrombosis                           |                                                                          |             
      Bilateral, Hyperplasia, Focal        |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +  +  +  +        +  +  +     +  +  +  +           +  +        +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    M  +  +  +        +  +  +     +  +  +  +           +  +        +  M  M|             
 _____________________________________________________________________________________________________________________|             
                                                             Page  68                                                               
NTP Experiment-Test: 05705-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 11:37:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 5| 7| 7| 7| 1| 1| 5| 7| 7| 1| 7| 6| 7| 6| 1| 4| 4| 7| 7| 1| 1| 7| 7| 7|             
                             DAY ON TEST   | 5| 5| 1| 3| 3| 8| 8| 8| 2| 2| 8| 2| 1| 3| 8| 8| 5| 5| 2| 2| 8| 8| 3| 3| 3|             
                                           | 6| 6| 8| 0| 1| 3| 3| 8| 8| 5| 3| 9| 1| 0| 7| 3| 6| 6| 9| 9| 3| 3| 0| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    15 MG/KG                               | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
     MALE                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
      Hyperplasia, Focal                   |                                                                          |             
      Hyperplasia                          |       2                                                                  |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |    +  +  +  +        M  +  +     +  +  +  +           +  +        +  +  +|             
      Hemorrhage                           |                                                                          |             
      Pars Distalis, Angiectasis           |                                        2                                 |             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hyperplasia           |          1                                                        2      |             
      Pars Intermedia, Hyperplasia, Focal  |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |    +  +  +  +        +  +  +     +  +  +  +           +  +        +  +  +|             
      C-Cell, Hyperplasia                  |             1              2                             1               |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Tissue NOS                              |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |    +  +  +  +        +  +  +     +  +  +  +           +  +        +  +  +|             
                                            __________________________________________________________________________|             
   Preputial Gland                         |    +  +  +  +        +  +  +     +  +  +  +           +  +        +  +  +|             
      Cyst                                 |                                                                          |             
      Hyperplasia                          |                            2                                             |             
      Inflammation, Acute                  |                         2  2                                             |             
      Inflammation, Chronic                |          1           2           1     2  2           1  1        1     2|             
      Inflammation, Chronic Active         |                                                                      1   |             
                                            __________________________________________________________________________|             
   Prostate                                |    +  +  +  +        +  +  +     +  +  +  +           +  +        +  +  +|             
      Hyperplasia, Focal                   |                                        1                             1   |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |    M  M  M  M        M  M  M     M  M  M  M           M  M        M  M  M|             
                                            __________________________________________________________________________|             
   Testes                                  |    +  +  +  +        +  +  +     +  +  +  +           +  +        +  +  +|             
      Atrophy                              |                         2                                                |             
      Bilateral, Interstitial Cell,        |                                                                          |             
          Hyperplasia                      |    2                                                                     |             
      Interstitial Cell, Hyperplasia       |                         1                                               2|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +  +  +  +        +  +  +     +  +  +  +           +  +        +  +  +|             
      Hyperplasia                          |                                                                          |             
      Myelofibrosis                        |                                                                          |             
      Myeloid Cell, Hyperplasia            |             3                                                            |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +  +  +  +        M  +  +     +  +  +  +           +  +        +  +  +|             
      Axillary, Hyperplasia                |             3                                                            |             
      Inguinal, Infiltration Cellular,     |                                                                          |             
           Plasma Cell                     |                                                                          |             
      Mediastinal, Hemorrhage              |                                                                          |             
      Mediastinal, Hyperplasia             |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  69                                                               
NTP Experiment-Test: 05705-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 11:37:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 5| 7| 7| 7| 1| 1| 5| 7| 7| 1| 7| 6| 7| 6| 1| 4| 4| 7| 7| 1| 1| 7| 7| 7|             
                             DAY ON TEST   | 5| 5| 1| 3| 3| 8| 8| 8| 2| 2| 8| 2| 1| 3| 8| 8| 5| 5| 2| 2| 8| 8| 3| 3| 3|             
                                           | 6| 6| 8| 0| 1| 3| 3| 8| 8| 5| 3| 9| 1| 0| 7| 3| 6| 6| 9| 9| 3| 3| 0| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    15 MG/KG                               | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
     MALE                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Pancreatic, Inflammation, Chronic    |                                                                          |             
      Renal, Hemorrhage                    |       2                                                                  |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |    +  +  +  +        M  +  +     +  +  +  +           +  +        +  +  +|             
      Congestion                           |                         2                                                |             
      Hemorrhage                           |                                                                          |             
      Hyperplasia                          |                                                                          |             
      Necrosis, Focal                      |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  |    +  +  +  +        +  +  +     +  +  +  +           +  +        +  +  +|             
      Fibrosis                             |       2                 2                                            2   |             
      Hematopoietic Cell Proliferation     |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
          Granulocytic                     |                                                                          |             
      Necrosis, Focal                      |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  |    +  I  +  +        +  +  +     +  +  +  +           +  +        +  +  +|             
      Ectasia                              |                         3                                                |             
      Hyperplasia                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    +  +  +  +        +  +  +     +  +  +  +           M  +        +  +  +|             
      Fibrosis                             |                                                                         1|             
      Hyperplasia                          |                         1  2                                         1   |             
      Mineralization                       |                         1                                                |             
      Pigmentation                         |                                                                          |             
      Duct, Ectasia                        |                                           2                              |             
                                            __________________________________________________________________________|             
   Skin                                    |    +  +  +  +        +  +  +     +  +  +  +           M  +        +  +  +|             
      Hemorrhage                           |             3                                                            |             
      Inflammation, Acute                  |             4                                                            |             
      Inflammation, Chronic Active         |                                                                          |             
      Subcutaneous Tissue, Edema           |                         2                                                |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +  +  +  +        +  +  +     +  +  +  +           +  +        +  +  +|             
      Fibrous Osteodystrophy               |                         2                                                |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +  +  +  +        +  +  +     +  +  +  +           +  +        +  +  +|             
      Hemorrhage, Focal                    |                                                                          |             
      Meninges, Vein, Cerebrum, Thrombosis |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |    +  +  +  +        +  +  +     +  +  +  +           +  +        +  +  +|             
      Congestion                           |                      1  1                                                |             
      Fibrosis, Multifocal                 |                                                                          |             
      Hemorrhage, Focal                    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  70                                                               
NTP Experiment-Test: 05705-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 11:37:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 5| 7| 7| 7| 1| 1| 5| 7| 7| 1| 7| 6| 7| 6| 1| 4| 4| 7| 7| 1| 1| 7| 7| 7|             
                             DAY ON TEST   | 5| 5| 1| 3| 3| 8| 8| 8| 2| 2| 8| 2| 1| 3| 8| 8| 5| 5| 2| 2| 8| 8| 3| 3| 3|             
                                           | 6| 6| 8| 0| 1| 3| 3| 8| 8| 5| 3| 9| 1| 0| 7| 3| 6| 6| 9| 9| 3| 3| 0| 1| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3| 3|             
    15 MG/KG                               | 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7| 8| 8| 8| 8| 8|             
     MALE                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Inflammation, Chronic                |    3        1                          1                 2               |             
      Alveolar Epithelium, Hyperplasia,    |                                                                          |             
           Focal                           |                                                                          |             
      Alveolar Epithelium, Hyperplasia     |                                                                          |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |       2                                                                  |             
      Alveolus, Pigmentation               |                                                                          |             
      Artery, Media, Hypertrophy           |                         2                                                |             
      Perivascular, Inflammation, Chronic  |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |    +  +  +  +        +  +  +     +  +  +  +           +  +        +  +  +|             
      Autolysis                            |                                                                          |             
      Foreign Body                         |                                                                         2|             
      Fungus                               |                      X                    X                              |             
      Mucosa, Inflammation, Acute          |          2                                                               |             
      Mucosa, Inflammation, Chronic        |                                                                          |             
      Mucosa, Inflammation, Chronic Active |                      3                    4                             2|             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Acute                           |                                  3                                       |             
      Respiratory Epithelium, Hyperplasia, |                                                                          |             
           Papillary                       |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 |    +  +  +  +        +  +  +     +  +  +  +           +  +        +  +  +|             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                                                         +|             
      Bilateral, Lens, Cataract            |                                                                          |             
      Lens, Cataract                       |                                                                         3|             
      Sclera, Mineralization, Focal        |                                                                         2|             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |    +  +  +  +        +  +  +     +  +  +  +           +  +        +  +  +|             
      Autolysis                            |                                           3                              |             
      Congestion                           |                                                                          |             
      Nephropathy                          |    2  4  3  2        3  4  3     3  3  3  3           4  3        4  3  4|             
      Cortex, Cyst                         |       2                                                  2               |             
      Pelvis, Inflammation, Acute          |                                                                          |             
      Pelvis, Transitional Epithelium,     |                                                                          |             
           Hyperplasia                     |       2                                                                  |             
      Renal Tubule, Epithelium,            |                                                                          |             
          Pigmentation                     |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    +  +  +  +        +  +  +     +  +  +  +           +  +        +  +  +|             
      Hemorrhage                           |                                                                          |             
      Transitional Epithelium, Hyperplasia |       2                                                                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  71                                                               
NTP Experiment-Test: 05705-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 11:37:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 2| 7| 7| 6| 1| 5| 7| 7| 6| 4| 4| 6| 6| 6| 4| 7| 6| 5| 6|              |            |
                             DAY ON TEST   | 8| 8| 3| 2| 9| 8| 5| 3| 3| 0| 1| 2| 4| 4| 3| 5| 1| 4| 9| 6|              |            |
                                           | 3| 4| 1| 8| 6| 3| 7| 2| 1| 2| 1| 7| 7| 7| 3| 6| 8| 7| 9| 8|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|              |      A     |
    15 MG/KG                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|              |      L     |
     MALE                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               |    +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +               |  53        |
                                            __________________________________________________________________________|____________|
   Intestine Large                         |    +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +               |  53        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  |    +  +  +  +     +  +  +  +  M  +  +  +  +     +  +  +  +               |  52        |
      Autolysis                            |             3                                                            |      1  3.0|
      Inflammation, Acute                  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  |    +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +               |  53        |
      Hyperplasia, Lymphoid                |                                                                          |      1  2.0|
      Parasite Metazoan                    |                                                       X                  |      6     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 |    +  +  +  M     +  +  +  +  +  +  +  +  +     +  +  +  +               |  52        |
                                            __________________________________________________________________________|____________|
   Intestine Small                         |    +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +               |  53        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               |    +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +               |  53        |
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  |    +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +               |  52        |
      Autolysis                            |          3  3                                                            |      3  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                |    +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +               |  52        |
      Autolysis                            |    4                                                                     |      2  3.0|
                                            __________________________________________________________________________|____________|
   Liver                                   |    +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +               |  53        |
      Angiectasis, Focal                   |                         2                                                |      1  2.0|
      Basophilic Focus                     |                                                                          |      1     |
      Basophilic Focus, Multiple           |                                                                          |     10     |
      Clear Cell Focus                     |                                                                          |      1     |
      Congestion                           |                                                                          |      2  1.5|
      Cytoplasmic Alteration, Focal        |                                                                          |      3  1.7|
      Hepatodiaphragmatic Nodule           |                                                                          |      2     |
      Hyperplasia, Focal                   |                      1                                                   |      1  1.0|
      Inflammation, Chronic                |                   1              2                                       |      3  1.3|
      Inflammation, Granulomatous,         |                                                                          |            |
          Multifocal                       |       1                                                                  |      3  1.0|
      Necrosis, Acute, Focal               |                                           2                              |      1  2.0|
      Thrombosis                           |                         X                                                |      1     |
      Vacuolization Cytoplasmic, Focal     |                                                                          |      1  1.0|
      Bile Duct, Hyperplasia               |                                     3                 2                  |     11  1.8|
      Centrilobular, Fatty Change          |                                     3                                    |      1  3.0|
      Centrilobular, Vacuolization         |                                                                          |            |
          Cytoplasmic                      |                                                                          |      1  3.0|
      Hepatocyte, Degeneration, Cystic,    |                                                                          |            |
           Focal                           |                      1                                                   |      3  1.3|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                        +                                 |   1        |
      Fat, Necrosis, Focal                 |                                        2                                 |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                |    +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +               |  53        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  72                                                               
NTP Experiment-Test: 05705-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 11:37:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 2| 7| 7| 6| 1| 5| 7| 7| 6| 4| 4| 6| 6| 6| 4| 7| 6| 5| 6|              |            |
                             DAY ON TEST   | 8| 8| 3| 2| 9| 8| 5| 3| 3| 0| 1| 2| 4| 4| 3| 5| 1| 4| 9| 6|              |            |
                                           | 3| 4| 1| 8| 6| 3| 7| 2| 1| 2| 1| 7| 7| 7| 3| 6| 8| 7| 9| 8|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|              |      A     |
    15 MG/KG                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|              |      L     |
     MALE                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Atrophy, Focal                       |       1           1  1     1        3           1  2     1               |     20  1.3|
      Congestion, Focal                    |             2                                                            |      1  2.0|
      Hyperplasia, Focal                   |                                                                          |      1  3.0|
      Inflammation, Chronic                |                                                    3                     |      1  3.0|
      Artery, Mineralization               |                                                                          |      1  2.0|
      Duct, Ectasia, Focal                 |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         |    +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +               |  53        |
      Inflammation, Acute, Focal           |                                                                          |      3  1.0|
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Duct, Inflammation, Acute            |       1                                                                  |      1  1.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 |    +  +  +        +  +  +  +  +  +  +  +  +     +  +  +  +               |  52        |
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    |    +  +  +        +  +  +  +  +  +  +  +  +     +  +  +  +               |  52        |
      Inflammation, Acute                  |                                        2           2                     |      4  1.8|
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
      Mineralization                       |                                                                          |      1  3.0|
      Epithelium, Hyperplasia              |                                                    2     1               |      6  1.5|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      |    +  +  +        +  +  +  +  +  +  +  +  +     +  +  +  +               |  52        |
      Infiltration Cellular, Lymphocyte    |    2                                                                     |      4  1.8|
      Inflammation, Acute                  |                                     2                                    |      1  2.0|
      Inflammation, Chronic                |                         2                                                |      2  1.5|
      Inflammation, Chronic Active         |                                        3                                 |      1  3.0|
      Mineralization                       |       2                                                                  |      4  2.5|
      Necrosis, Focal                      |          1                                         2                     |      5  1.4|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            |    +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +               |  53        |
      Inflammation, Acute                  |       3                                                                  |      1  3.0|
      Aorta, Mineralization                |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Heart                                   |    +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +               |  53        |
      Inflammation, Chronic                |    1  3  2  2     1  1  2        2  2  1        1     1  1               |     45  1.8|
      Mineralization                       |       2                                                                  |      3  2.3|
      Atrium Left, Thrombosis              |                                     1                                    |      4  2.3|
      Valve, Thrombosis                    |                            3                                             |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           |    +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +               |  52        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   |    +  +  +  +     M  +  +  +  +  +  +  +  +     +  +  +  +               |  51        |
      Cyst                                 |                                                                          |      1  1.0|
      Hyperplasia, Focal                   |                         1           2  2                                 |      8  1.4|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  73                                                               
NTP Experiment-Test: 05705-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 11:37:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 2| 7| 7| 6| 1| 5| 7| 7| 6| 4| 4| 6| 6| 6| 4| 7| 6| 5| 6|              |            |
                             DAY ON TEST   | 8| 8| 3| 2| 9| 8| 5| 3| 3| 0| 1| 2| 4| 4| 3| 5| 1| 4| 9| 6|              |            |
                                           | 3| 4| 1| 8| 6| 3| 7| 2| 1| 2| 1| 7| 7| 7| 3| 6| 8| 7| 9| 8|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|              |      A     |
    15 MG/KG                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|              |      L     |
     MALE                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia                          |                                                                          |      1  3.0|
      Hypertrophy, Focal                   |             1                                                            |      5  1.0|
      Necrosis, Focal                      |       1  1                                                               |      2  1.0|
      Vacuolization Cytoplasmic, Focal     |                                     2                    2               |     10  1.3|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  |    +  +  +  +     M  +  +  +  +  +  +  +  +     +  +  +  +               |  50        |
      Hyperplasia, Focal                   |                                        1                                 |      6  1.2|
      Thrombosis                           |                                                 4                        |      1  4.0|
      Bilateral, Hyperplasia, Focal        |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      |    +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +               |  53        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       |    +  +  +  +     +  +  +  +  +  M  +  +  +     +  +  +  +               |  47        |
      Hyperplasia, Focal                   |                                                                          |      1  1.0|
      Hyperplasia                          |                                                                          |      3  2.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         |    +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +               |  52        |
      Hemorrhage                           |                         1                                                |      1  1.0|
      Pars Distalis, Angiectasis           |       2                 1                                                |      3  1.7|
      Pars Distalis, Cyst                  |                                                 2                        |      2  1.5|
      Pars Distalis, Hyperplasia           |                                     1                 2                  |      7  1.3|
      Pars Intermedia, Hyperplasia, Focal  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           |    +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +               |  53        |
      C-Cell, Hyperplasia                  |                      2                                                   |      6  1.5|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Tissue NOS                              |                                                                          |   1        |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              |    M  +  +  M     +  +  +  +  +  +  +  +  +     +  +  +  +               |  50        |
                                            __________________________________________________________________________|____________|
   Preputial Gland                         |    +  +  +  M     +  +  +  +  +  +  +  +  +     +  +  +  +               |  52        |
      Cyst                                 |                         1                                                |      1  1.0|
      Hyperplasia                          |                                                                          |      2  2.0|
      Inflammation, Acute                  |                                                                          |      7  2.1|
      Inflammation, Chronic                |    1  2           1  1  1  1     2  1  1  1     1     1  2               |     28  1.3|
      Inflammation, Chronic Active         |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Prostate                                |    +  +  +  M     +  +  +  +  +  +  +  +  +     +  +  +  +               |  52        |
      Hyperplasia, Focal                   |                      1                                                   |      4  1.5|
      Inflammation, Chronic                |                   2                    1              1                  |      5  1.2|
      Inflammation, Chronic Active         |       3                                                  1               |      2  2.0|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         |    M  M  M  M     M  M  M  M  M  M  M  M  M     M  M  M  M               |            |
                                            __________________________________________________________________________|____________|
   Testes                                  |    M  +  +  M     +  +  +  +  +  +  +  +  +     +  +  +  +               |  51        |
      Atrophy                              |                   2                       4                              |      6  2.7|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  74                                                               
NTP Experiment-Test: 05705-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 11:37:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 2| 7| 7| 6| 1| 5| 7| 7| 6| 4| 4| 6| 6| 6| 4| 7| 6| 5| 6|              |            |
                             DAY ON TEST   | 8| 8| 3| 2| 9| 8| 5| 3| 3| 0| 1| 2| 4| 4| 3| 5| 1| 4| 9| 6|              |            |
                                           | 3| 4| 1| 8| 6| 3| 7| 2| 1| 2| 1| 7| 7| 7| 3| 6| 8| 7| 9| 8|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|              |      A     |
    15 MG/KG                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|              |      L     |
     MALE                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Bilateral, Interstitial Cell,        |                                                                          |            |
          Hyperplasia                      |                                                                          |      1  2.0|
      Interstitial Cell, Hyperplasia       |                               1  2                                       |      6  1.3|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             |    +  +  +  +     M  +  +  +  +  +  +  +  +     +  +  +  +               |  52        |
      Hyperplasia                          |                                           2                              |      2  2.0|
      Myelofibrosis                        |                                                 2                        |      2  1.5|
      Myeloid Cell, Hyperplasia            |                               3                 2                        |      3  2.7|
                                            __________________________________________________________________________|____________|
   Lymph Node                              |    +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +               |  52        |
      Axillary, Hyperplasia                |                                                                          |      1  3.0|
      Inguinal, Infiltration Cellular,     |                                                                          |            |
           Plasma Cell                     |                                           2                              |      1  2.0|
      Mediastinal, Hemorrhage              |                               2                                          |      1  2.0|
      Mediastinal, Hyperplasia             |                               2                                          |      1  2.0|
      Pancreatic, Inflammation, Chronic    |                                                                          |      1  4.0|
      Renal, Hemorrhage                    |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  |    +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +               |  52        |
      Congestion                           |                                                                          |      1  2.0|
      Hemorrhage                           |             2                                                            |      2  1.5|
      Hyperplasia                          |                               2                                          |      1  2.0|
      Necrosis, Focal                      |                                                          2               |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  |    +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +               |  53        |
      Fibrosis                             |                                                 2                        |      5  2.0|
      Hematopoietic Cell Proliferation     |                                           2     2                        |      2  2.0|
      Hematopoietic Cell Proliferation     |                                                                          |            |
          Granulocytic                     |                               3                                          |      1  3.0|
      Necrosis, Focal                      |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  |    +  +  +  +     +  I  +  +  +  +  I  +  +     +  +  +  +               |  48        |
      Ectasia                              |                                                                          |      1  3.0|
      Hyperplasia                          |    2                                                                     |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           |    +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +               |  52        |
      Fibrosis                             |                                                                          |      1  1.0|
      Hyperplasia                          |       1                                                  1               |      6  1.2|
      Mineralization                       |                                                                          |      1  1.0|
      Pigmentation                         |                         1                                                |      1  1.0|
      Duct, Ectasia                        |       1           1                             1                        |      8  1.3|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  75                                                               
NTP Experiment-Test: 05705-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 11:37:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 2| 7| 7| 6| 1| 5| 7| 7| 6| 4| 4| 6| 6| 6| 4| 7| 6| 5| 6|              |            |
                             DAY ON TEST   | 8| 8| 3| 2| 9| 8| 5| 3| 3| 0| 1| 2| 4| 4| 3| 5| 1| 4| 9| 6|              |            |
                                           | 3| 4| 1| 8| 6| 3| 7| 2| 1| 2| 1| 7| 7| 7| 3| 6| 8| 7| 9| 8|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|              |      A     |
    15 MG/KG                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|              |      L     |
     MALE                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 INTEGUMENTARY SYSTEM - cont               |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Skin                                    |    +  +  +  +     +  +  +  +  M  +  +  +  +     +  +  +  +               |  51        |
      Hemorrhage                           |                                                                          |      1  3.0|
      Inflammation, Acute                  |                                                                          |      1  4.0|
      Inflammation, Chronic Active         |                                           3                              |      1  3.0|
      Subcutaneous Tissue, Edema           |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    |    +  +  +  +     M  +  +  +  +  +  +  +  +     +  +  +  +               |  52        |
      Fibrous Osteodystrophy               |       2                                                                  |      4  2.0|
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   |    +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +               |  53        |
      Hemorrhage, Focal                    |                   2                                                      |      1  2.0|
      Meninges, Vein, Cerebrum, Thrombosis |                                                                          |      1     |
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    |    +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +               |  53        |
      Congestion                           |    2                                   2              1                  |      6  1.3|
      Fibrosis, Multifocal                 |                                                                          |      2  1.0|
      Hemorrhage, Focal                    |       2                                                                  |      2  1.5|
      Inflammation, Chronic                |                                                                          |      4  1.8|
      Alveolar Epithelium, Hyperplasia,    |                                                                          |            |
           Focal                           |                                                                          |      1  2.0|
      Alveolar Epithelium, Hyperplasia     |                                                                          |      1  1.0|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |                                     2                                    |      4  1.8|
      Alveolus, Pigmentation               |                                                                          |      1  1.0|
      Artery, Media, Hypertrophy           |                                                                          |      1  2.0|
      Perivascular, Inflammation, Chronic  |       1                                                                  |      2  1.0|
                                            __________________________________________________________________________|____________|
   Nose                                    |    +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +               |  53        |
      Autolysis                            |    3                                                                     |      2  2.5|
      Foreign Body                         |                   2                                                      |      3  2.0|
      Fungus                               |                         X        X     X           X     X               |      8     |
      Mucosa, Inflammation, Acute          |                                                 2                        |      4  1.8|
      Mucosa, Inflammation, Chronic        |                   2                                3  1                  |      3  2.0|
      Mucosa, Inflammation, Chronic Active |                         3        3     4                 2               |      8  3.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Acute                           |                                                                          |      1  3.0|
      Respiratory Epithelium, Hyperplasia, |                                                                          |            |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  76                                                               
NTP Experiment-Test: 05705-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 11:37:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 1| 2| 7| 7| 6| 1| 5| 7| 7| 6| 4| 4| 6| 6| 6| 4| 7| 6| 5| 6|              |            |
                             DAY ON TEST   | 8| 8| 3| 2| 9| 8| 5| 3| 3| 0| 1| 2| 4| 4| 3| 5| 1| 4| 9| 6|              |            |
                                           | 3| 4| 1| 8| 6| 3| 7| 2| 1| 2| 1| 7| 7| 7| 3| 6| 8| 7| 9| 8|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4| 4|              |      A     |
    15 MG/KG                               | 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1| 2| 2| 2| 2| 2|              |      L     |
     MALE                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 RESPIRATORY SYSTEM - cont                 |                                                                          |            |
                                           |                                                                          |            |
           Papillary                       |                         3                                                |      1  3.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 |    +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +               |  53        |
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                        +                                 |   3        |
      Bilateral, Lens, Cataract            |                                                                          |      1  1.0|
      Lens, Cataract                       |                                                                          |      1  3.0|
      Sclera, Mineralization, Focal        |                                        2                                 |      3  2.0|
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  |    +  +  +  +     +  +  +  +  +  +  +  +  +     +  +  +  +               |  53        |
      Autolysis                            |          2  3                 3        3                                 |      6  2.8|
      Congestion                           |    2                                                                     |      1  2.0|
      Nephropathy                          |       4  2  3     2  3  3  2     2  2  2  2     2  2  3  3               |     51  2.7|
      Cortex, Cyst                         |                                                                          |      2  2.0|
      Pelvis, Inflammation, Acute          |       2                                                                  |      1  2.0|
      Pelvis, Transitional Epithelium,     |                                                                          |            |
           Hyperplasia                     |       3                                                                  |      3  2.3|
      Renal Tubule, Epithelium,            |                                                                          |            |
          Pigmentation                     |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         |    +  +  +  M     +  +  +  +  +  +  +  +  +     +  +  +  +               |  52        |
      Hemorrhage                           |                                                                          |      1  2.0|
      Transitional Epithelium, Hyperplasia |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  77                                                               
NTP Experiment-Test: 05705-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 11:37:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 5| 6| 1| 1| 4| 5| 6| 7| 1| 4| 4| 4| 6| 1| 1| 1| 6| 6| 5| 3| 7| 7| 6|             
                             DAY ON TEST   | 5| 5| 6| 2| 8| 8| 7| 2| 3| 3| 8| 5| 5| 8| 4| 8| 8| 8| 5| 9| 5| 5| 2| 1| 3|             
                                           | 6| 6| 4| 4| 3| 3| 7| 2| 2| 2| 3| 6| 6| 6| 2| 3| 3| 3| 7| 0| 6| 1| 9| 8| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    30 MG/KG                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
     MALE                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |       +  +        +  +  +  +           +  +           +  +  +  +  +  +  +|             
      Wall, Inflammation, Chronic          |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         |       +  +        +  +  +  +           +  +           +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |       +  +        +  +  +  +           +  +           +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |       +  +        +  +  +  +           +  +           +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                            X                                            X|             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |       +  +        +  +  +  +           +  +           +  +  +  +  +  +  +|             
      Parasite Metazoan                    |                   X                                                      |             
                                            __________________________________________________________________________|             
   Intestine Small                         |       +  +        +  +  +  +           +  +           +  +  +  +  +  +  +|             
      Perivascular, Inflammation, Chronic  |                                                                          |             
      Serosa, Inflammation, Chronic        |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |       +  +        +  +  +  +           +  +           +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Necrosis, Acute, Focal               |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |       +  +        +  +  +  +           +  +           M  +  +  +  +  +  +|             
      Autolysis                            |                                                                          |             
      Parasite Metazoan                    |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |       +  +        +  +  +  +           +  +           +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Liver                                   |       +  +        +  +  +  +           +  +           +  +  +  +  +  +  +|             
      Basophilic Focus                     |                                                                          |             
      Basophilic Focus, Multiple           |                            X                                             |             
      Clear Cell Focus                     |                                                                          |             
      Congestion                           |                                                                          |             
      Cytoplasmic Alteration, Focal        |                            2                                             |             
      Inflammation, Acute, Multifocal      |                                                                1         |             
      Necrosis, Acute, Focal               |                                                                          |             
      Vacuolization Cytoplasmic, Focal     |                                                          3               |             
      Bile Duct, Hyperplasia               |                   1                       1                       1      |             
      Centrilobular, Fatty Change          |                                                                          |             
      Hepatocyte, Degeneration, Cystic,    |                                                                          |             
           Focal                           |                                                                          |             
      Hepatocyte, Hypertrophy, Focal       |                                                                          |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |       +  +        +  +  +  +           +  +           +  +  +  +  +  +  +|             
      Atrophy, Focal                       |       1           1     3                             1                 1|             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |                                                                          |             
      Duct, Ectasia, Focal                 |                                                                          |             
      Perivascular, Inflammation, Chronic  |                            2                                             |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |       +  +        +  +  +  +           +  +           +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
      Duct, Inflammation, Chronic Active   |                                                                1         |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  78                                                               
NTP Experiment-Test: 05705-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 11:37:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 5| 6| 1| 1| 4| 5| 6| 7| 1| 4| 4| 4| 6| 1| 1| 1| 6| 6| 5| 3| 7| 7| 6|             
                             DAY ON TEST   | 5| 5| 6| 2| 8| 8| 7| 2| 3| 3| 8| 5| 5| 8| 4| 8| 8| 8| 5| 9| 5| 5| 2| 1| 3|             
                                           | 6| 6| 4| 4| 3| 3| 7| 2| 2| 2| 3| 6| 6| 6| 2| 3| 3| 3| 7| 0| 6| 1| 9| 8| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    30 MG/KG                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
     MALE                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Periductular, Inflammation, Chronic  |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach                                 |       +  +        +  +  +  +           +  +           +  +  +  +  +  +  +|             
      Perivascular, Inflammation, Chronic  |                                                                          |             
      Serosa, Inflammation, Chronic        |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |       +  +        +  +  +  +           +  +           +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                                                          3           2   |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         |                            3                                             |             
      Mineralization                       |                                                                          |             
      Epithelium, Hyperplasia              |                            2                                         1   |             
      Serosa, Inflammation, Chronic        |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |       +  +        +  +  +  +           +  +           +  +  +  +  +  +  +|             
      Hemorrhage, Focal                    |                                                                          |             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |                                                                      2   |             
      Inflammation, Chronic                |                                                                          |             
      Mineralization                       |                                                                          |             
      Necrosis, Focal                      |                                                          1           3   |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                                          |             
      Epithelium, Hyperplasia, Focal       |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |       +  +        +  +  +  +           +  +           +  +  +  +  +  +  +|             
      Aorta, Mineralization                |                                                                          |             
                                            __________________________________________________________________________|             
   Heart                                   |       +  +        +  +  +  +           +  +           +  +  +  +  +  +  +|             
      Inflammation, Chronic                |       1  1        1     1  3           2  2           2  2  1     2  1  1|             
      Mineralization                       |                                                                          |             
      Atrium Left, Thrombosis              |                                                                      3   |             
      Perivascular, Inflammation, Chronic  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |       +  +        +  +  +  +           +  +           +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |       +  +        +  +  +  +           +  +           +  +  +  +  +  +  +|             
      Hemorrhage, Focal                    |       2                                                                  |             
      Hyperplasia, Focal                   |                            2                                             |             
      Hypertrophy, Focal                   |                                                                         1|             
      Vacuolization Cytoplasmic, Focal     |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |       +  +        +  +  +  +           +  +           +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                        1                          2  2   |             
      Mineralization, Focal                |                                                                          |             
      Thrombosis                           |                                                                          |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |       +  +        +  +  +  +           +  +           +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |       +  M        +  +  +  M           +  +           +  +  M  +  M  I  M|             
      Hyperplasia                          |                                                       1                  |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  79                                                               
NTP Experiment-Test: 05705-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 11:37:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 5| 6| 1| 1| 4| 5| 6| 7| 1| 4| 4| 4| 6| 1| 1| 1| 6| 6| 5| 3| 7| 7| 6|             
                             DAY ON TEST   | 5| 5| 6| 2| 8| 8| 7| 2| 3| 3| 8| 5| 5| 8| 4| 8| 8| 8| 5| 9| 5| 5| 2| 1| 3|             
                                           | 6| 6| 4| 4| 3| 3| 7| 2| 2| 2| 3| 6| 6| 6| 2| 3| 3| 3| 7| 0| 6| 1| 9| 8| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    30 MG/KG                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
     MALE                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |       +  +        +  +  +  +           +  +           +  +  +  +  +  +  +|             
      Pars Distalis, Angiectasis           |                                                                          |             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hyperplasia           |                                                                          |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |       +  +        +  +  +  +           +  +           +  +  +  +  +  +  +|             
      C-Cell, Hyperplasia                  |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |       +  +        +  +  +  +           +  +           +  +  +  +  +  +  +|             
                                            __________________________________________________________________________|             
   Penis                                   |                                                                          |             
      Inflammation, Acute                  |                                                                          |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |       +  +        +  +  +  +           +  +           +  +  +  +  +  +  +|             
      Ectasia                              |                                                                          |             
      Inflammation, Acute                  |                                                       3  2  1  2         |             
      Inflammation, Chronic                |                   1        1              1                              |             
                                            __________________________________________________________________________|             
   Prostate                                |       +  +        +  +  +  +           +  +           +  +  +  +  +  +  +|             
      Hyperplasia, Focal                   |                                                                          |             
      Inflammation, Acute                  |                                        1                                 |             
      Inflammation, Chronic                |                                                                          |             
      Mineralization                       |                                                                   2      |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |       +  M        M  +  M  M           M  M           M  M  M  M  M  M  M|             
                                            __________________________________________________________________________|             
   Testes                                  |       +  +        +  +  +  +           +  +           +  +  +  +  +  +  +|             
      Atrophy                              |                                                                          |             
      Hemorrhage                           |                                                                          |             
      Infarct, Diffuse                     |                                                                          |             
      Interstitial Cell, Hyperplasia       |          1              2                                                |             
      Seminiferous Tubule, Degeneration    |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |       +  +        +  +  +  +           +  +           +  +  +  +  M  +  +|             
      Hypoplasia                           |          2                                                               |             
      Myelofibrosis                        |                                                          2           2   |             
      Myeloid Cell, Hyperplasia            |                                        2                                 |             
                                            __________________________________________________________________________|             
   Lymph Node                              |       +  +        +  +  +  +           +  +           +  +  +  +  +  +  +|             
      Mediastinal, Congestion              |                                                          2               |             
      Pancreatic, Fibrosis, Focal          |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |       +  +        +  +  +  +           +  +           +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Hyperplasia, Re Cell                 |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  |       +  +        +  +  +  +           +  +           +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  80                                                               
NTP Experiment-Test: 05705-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 11:37:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 5| 6| 1| 1| 4| 5| 6| 7| 1| 4| 4| 4| 6| 1| 1| 1| 6| 6| 5| 3| 7| 7| 6|             
                             DAY ON TEST   | 5| 5| 6| 2| 8| 8| 7| 2| 3| 3| 8| 5| 5| 8| 4| 8| 8| 8| 5| 9| 5| 5| 2| 1| 3|             
                                           | 6| 6| 4| 4| 3| 3| 7| 2| 2| 2| 3| 6| 6| 6| 2| 3| 3| 3| 7| 0| 6| 1| 9| 8| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    30 MG/KG                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
     MALE                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Fibrosis                             |                                                                          |             
      Hematopoietic Cell Proliferation     |                                                                          |             
          Granulocytic                     |                                        3                                 |             
                                            __________________________________________________________________________|             
   Thymus                                  |       +  +        +  +  +  +           +  +           +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Cyst, Multiple                       |                                                                      2   |             
      Hyperplasia                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |       +  +        +  +  +  +           +  +           +  +  +  +  +  +  +|             
      Hyperplasia, Cystic                  |                            2                                             |             
      Hyperplasia                          |                         1                                            2  1|             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    |       +  +        +  +  +  +           +  +           +  +  +  +  +  +  +|             
      Inflammation, Chronic, Focal         |                                                       3                  |             
      Face, Inflammation, Acute, Focal     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |       +  +        +  +  +  +           +  +           +  +  +  +  M  +  +|             
      Fibrous Osteodystrophy               |                                                                          |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |       +  +        +  +  +  +           +  +           +  +  +  +  +  +  +|             
      Hemorrhage, Focal                    |                                                                          |             
      Hydrocephalus                        |                                                                          |             
      Cerebellum, Pigmentation, Focal      |                                                                          |             
      Thalamus, Inflammation, Chronic,     |                                                                          |             
           Focal                           |                                                                         2|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |       +  +        +  +  +  +           +  +           +  +  +  +  +  +  +|             
      Congestion                           |          2           2                                      2            |             
      Inflammation, Chronic                |                            1                             1        1      |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                                                                          |             
      Bronchiole, Inflammation, Chronic    |                                                                          |             
          Active, Multifocal               |                                                                          |             
      Peribronchial, Infiltration Cellular,|                                                                          |             
           Lymphocyte                      |                                                                          |             
      Perivascular, Inflammation, Chronic  |                                                                          |             
      Pleura, Fibrosis, Focal              |                   1                                                      |             
      Pleura, Infiltration Cellular, Focal,|                                                                          |             
           Histiocyte                      |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  81                                                               
NTP Experiment-Test: 05705-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 11:37:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 4| 4| 5| 6| 1| 1| 4| 5| 6| 7| 1| 4| 4| 4| 6| 1| 1| 1| 6| 6| 5| 3| 7| 7| 6|             
                             DAY ON TEST   | 5| 5| 6| 2| 8| 8| 7| 2| 3| 3| 8| 5| 5| 8| 4| 8| 8| 8| 5| 9| 5| 5| 2| 1| 3|             
                                           | 6| 6| 4| 4| 3| 3| 7| 2| 2| 2| 3| 6| 6| 6| 2| 3| 3| 3| 7| 0| 6| 1| 9| 8| 2|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    30 MG/KG                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0| 1| 1| 1| 1| 1|             
     MALE                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Subpleura, Inflammation, Chronic     |                                                                          |             
                                            __________________________________________________________________________|             
   Nose                                    |       +  +        +  +  +  +           +  +           +  +  +  +  +  +  +|             
      Autolysis                            |       3                                                                  |             
      Congestion                           |          2                                                               |             
      Fungus                               |                                        X                                 |             
      Metaplasia, Squamous                 |                                                                          |             
      Mucosa, Inflammation, Acute          |                                                                         2|             
      Mucosa, Inflammation, Chronic Active |                                        4                                 |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Acute                           |                                                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Chronic                         |                                                                          |             
      Vomeronasal Organ, Inflammation,     |                                                                          |             
           Acute                           |                                                       1                  |             
                                            __________________________________________________________________________|             
   Trachea                                 |       +  +        +  +  +  +           +  +           +  +  +  +  +  +  +|             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                        +                                 |             
      Bilateral, Lens, Cataract            |                                                                          |             
      Lens, Cataract                       |                                        4                                 |             
      Retina, Degeneration                 |                                        4                                 |             
      Sclera, Mineralization, Focal        |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |       +  +        +  +  +  +           +  +           +  +  +  +  +  +  +|             
      Congestion                           |                                                                          |             
      Nephropathy                          |       1  2        1  2  2  4           2  3           3  3  2  1  4  1  2|             
      Pelvis, Transitional Epithelium,     |                                                                          |             
           Hyperplasia                     |                                                                          |             
      Renal Tubule, Epithelium,            |                                                                          |             
          Pigmentation                     |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |       +  +        +  +  +  +           +  +           +  +  +  +  +  +  +|             
      Inflammation, Acute                  |                                                                          |             
      Transitional Epithelium, Hyperplasia,|                                                                          |             
           Focal, Papillary                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  82                                                               
NTP Experiment-Test: 05705-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 11:37:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 5| 6| 7| 6| 3| 4| 6| 5| 7| 5| 7| 6| 6| 7| 1| 3| 4| 7| 7| 1| 4| 4| 6| 7|             
                             DAY ON TEST   | 8| 2| 9| 2| 3| 3| 5| 5| 7| 3| 1| 3| 6| 8| 3| 8| 6| 5| 3| 1| 8| 1| 5| 7| 3|             
                                           | 3| 8| 8| 9| 8| 9| 6| 3| 7| 0| 9| 1| 9| 2| 0| 3| 6| 7| 2| 8| 3| 7| 6| 2| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    30 MG/KG                               | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
     MALE                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM                         |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Esophagus                               |    +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +     +     +  +|             
      Wall, Inflammation, Chronic          |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Large                         |    +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +     +     +  +|             
                                            __________________________________________________________________________|             
   Intestine Large, Cecum                  |    +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +     +     +  +|             
      Inflammation, Acute                  |                                        2                                 |             
                                            __________________________________________________________________________|             
   Intestine Large, Colon                  |    +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +     +     +  +|             
      Parasite Metazoan                    |    X     X     X                 X              X              X         |             
                                            __________________________________________________________________________|             
   Intestine Large, Rectum                 |    +  +  +  +  +     +  +  +  +  +  +  +  +     I  +  +  +     +     +  +|             
      Parasite Metazoan                    |                                                                X         |             
                                            __________________________________________________________________________|             
   Intestine Small                         |    +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +     +     +  +|             
      Perivascular, Inflammation, Chronic  |                                                                          |             
      Serosa, Inflammation, Chronic        |                                                                          |             
                                            __________________________________________________________________________|             
   Intestine Small, Duodenum               |    +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +     +     +  +|             
      Inflammation, Chronic                |                                                                          |             
      Necrosis, Acute, Focal               |                      2                                                   |             
                                            __________________________________________________________________________|             
   Intestine Small, Ileum                  |    +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +     A     +  +|             
      Autolysis                            |                                                                          |             
      Parasite Metazoan                    |    X                                                                     |             
                                            __________________________________________________________________________|             
   Intestine Small, Jejunum                |    +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +     A     +  +|             
                                            __________________________________________________________________________|             
   Liver                                   |    +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +     +     +  +|             
      Basophilic Focus                     |                                                          1               |             
      Basophilic Focus, Multiple           |                                  X        X                              |             
      Clear Cell Focus                     |                                                          X               |             
      Congestion                           |                                                                          |             
      Cytoplasmic Alteration, Focal        |                                        3                                 |             
      Inflammation, Acute, Multifocal      |                                                                          |             
      Necrosis, Acute, Focal               |                         1                                1               |             
      Vacuolization Cytoplasmic, Focal     |                                                                          |             
      Bile Duct, Hyperplasia               |       2  3                 2              1        1  3  1               |             
      Centrilobular, Fatty Change          |                                                                          |             
      Hepatocyte, Degeneration, Cystic,    |                                                                          |             
           Focal                           |                                                                         2|             
      Hepatocyte, Hypertrophy, Focal       |                      3                                                   |             
                                            __________________________________________________________________________|             
   Mesentery                               |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
                                            __________________________________________________________________________|             
   Pancreas                                |    +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +     +     +  +|             
      Atrophy, Focal                       |                                                    1                 1  1|             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |                                                                          |             
      Duct, Ectasia, Focal                 |                                                                          |             
      Perivascular, Inflammation, Chronic  |                                                                          |             
                                            __________________________________________________________________________|             
   Salivary Glands                         |    +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +     +     +  +|             
      Inflammation, Chronic                |                                                                          |             
      Duct, Inflammation, Chronic Active   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  83                                                               
NTP Experiment-Test: 05705-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 11:37:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 5| 6| 7| 6| 3| 4| 6| 5| 7| 5| 7| 6| 6| 7| 1| 3| 4| 7| 7| 1| 4| 4| 6| 7|             
                             DAY ON TEST   | 8| 2| 9| 2| 3| 3| 5| 5| 7| 3| 1| 3| 6| 8| 3| 8| 6| 5| 3| 1| 8| 1| 5| 7| 3|             
                                           | 3| 8| 8| 9| 8| 9| 6| 3| 7| 0| 9| 1| 9| 2| 0| 3| 6| 7| 2| 8| 3| 7| 6| 2| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    30 MG/KG                               | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
     MALE                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ALIMENTARY SYSTEM - cont                  |                                                                          |             
                                           |                                                                          |             
      Periductular, Inflammation, Chronic  |                                                 1                        |             
                                            __________________________________________________________________________|             
   Stomach                                 |    +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +     +     +  +|             
      Perivascular, Inflammation, Chronic  |                                                                          |             
      Serosa, Inflammation, Chronic        |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Forestomach                    |    +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +     +     +  +|             
      Inflammation, Acute                  |                                                                          |             
      Inflammation, Chronic                |                                                                          |             
      Inflammation, Chronic Active         |                                                                          |             
      Mineralization                       |       2                                                  2               |             
      Epithelium, Hyperplasia              |                                                                          |             
      Serosa, Inflammation, Chronic        |                                                                          |             
                                            __________________________________________________________________________|             
   Stomach, Glandular                      |    +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +     +     +  +|             
      Hemorrhage, Focal                    |                                                                          |             
      Infiltration Cellular, Focal,        |                                                                          |             
          Lymphocyte                       |                      2                             2                     |             
      Inflammation, Chronic                |                               2                                          |             
      Mineralization                       |       2                    2                             3               |             
      Necrosis, Focal                      |                                                                          |             
                                            __________________________________________________________________________|             
   Tongue                                  |                                                       +                  |             
      Epithelium, Hyperplasia, Focal       |                                                       3                  |             
 _____________________________________________________________________________________________________________________|             
 CARDIOVASCULAR SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Blood Vessel                            |    +  +  +  +  M     +  +  +  +  +  +  +  +     +  +  +  +     +     +  +|             
      Aorta, Mineralization                |       3                                                  2               |             
                                            __________________________________________________________________________|             
   Heart                                   |    +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +     +     +  +|             
      Inflammation, Chronic                |    1     1  2  1        1  2     2  2  2  3     1  2  1  3     1     2  2|             
      Mineralization                       |       3                                                  3               |             
      Atrium Left, Thrombosis              |                                  X                       3               |             
      Perivascular, Inflammation, Chronic  |                                                                         3|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM                          |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Adrenal Gland                           |    +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +     +     +  +|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Cortex                   |    +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +     +     +  +|             
      Hemorrhage, Focal                    |                                                                          |             
      Hyperplasia, Focal                   |                            2              1              2               |             
      Hypertrophy, Focal                   |          2                                            2                  |             
      Vacuolization Cytoplasmic, Focal     |          2           2                                                  2|             
                                            __________________________________________________________________________|             
   Adrenal Gland, Medulla                  |    +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +     +     +  +|             
      Hyperplasia, Focal                   |                                     2                    1           2   |             
      Mineralization, Focal                |                            3                                             |             
      Thrombosis                           |                                        3                                 |             
                                            __________________________________________________________________________|             
   Islets, Pancreatic                      |    +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +     +     +  +|             
                                            __________________________________________________________________________|             
   Parathyroid Gland                       |    +  +  +  +  +     +  M  +  +  +  +  +  M     +  +  M  +     M     M  +|             
      Hyperplasia                          |       4                    1                             2               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  84                                                               
NTP Experiment-Test: 05705-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 11:37:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 5| 6| 7| 6| 3| 4| 6| 5| 7| 5| 7| 6| 6| 7| 1| 3| 4| 7| 7| 1| 4| 4| 6| 7|             
                             DAY ON TEST   | 8| 2| 9| 2| 3| 3| 5| 5| 7| 3| 1| 3| 6| 8| 3| 8| 6| 5| 3| 1| 8| 1| 5| 7| 3|             
                                           | 3| 8| 8| 9| 8| 9| 6| 3| 7| 0| 9| 1| 9| 2| 0| 3| 6| 7| 2| 8| 3| 7| 6| 2| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    30 MG/KG                               | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
     MALE                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 ENDOCRINE SYSTEM - cont                   |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Pituitary Gland                         |    +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +     +     +  +|             
      Pars Distalis, Angiectasis           |                                        2                                 |             
      Pars Distalis, Cyst                  |                                                                          |             
      Pars Distalis, Hyperplasia           |                      2                 2                                 |             
                                            __________________________________________________________________________|             
   Thyroid Gland                           |    +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +     +     +  +|             
      C-Cell, Hyperplasia                  |                                           1                              |             
 _____________________________________________________________________________________________________________________|             
 GENERAL BODY SYSTEM                       |                                                                          |             
                                           |                                                                          |             
    None                                   |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 GENITAL SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Epididymis                              |    +  +  +  +  +     +  M  +  +  +  +  +  +     +  +  +  +     +     +  +|             
                                            __________________________________________________________________________|             
   Penis                                   |                         +                                                |             
      Inflammation, Acute                  |                         3                                                |             
                                            __________________________________________________________________________|             
   Preputial Gland                         |    +  +  +  +  +     +  +  +  +  +  +  +  +     +  M  +  +     +     +  +|             
      Ectasia                              |                                     3                                    |             
      Inflammation, Acute                  |                                     2                    2               |             
      Inflammation, Chronic                |                                  1  1     1           1        1     2  1|             
                                            __________________________________________________________________________|             
   Prostate                                |    +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +     +     +  +|             
      Hyperplasia, Focal                   |             2                                                            |             
      Inflammation, Acute                  |                      3                                                   |             
      Inflammation, Chronic                |          3                                                               |             
      Mineralization                       |                                                                          |             
                                            __________________________________________________________________________|             
   Seminal Vesicle                         |    M  M  M  M  M     M  M  M  M  M  M  M  M     M  M  M  M     M     M  M|             
                                            __________________________________________________________________________|             
   Testes                                  |    +  +  +  +  +     +  M  +  +  +  +  +  +     +  +  +  +     +     +  +|             
      Atrophy                              |                                                                          |             
      Hemorrhage                           |                                                          4               |             
      Infarct, Diffuse                     |                                                                          |             
      Interstitial Cell, Hyperplasia       |                            2  1                    2                     |             
      Seminiferous Tubule, Degeneration    |                            4                                             |             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone Marrow                             |    +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +     +     +  +|             
      Hypoplasia                           |                                        4                                 |             
      Myelofibrosis                        |                                                                          |             
      Myeloid Cell, Hyperplasia            |                                                                          |             
                                            __________________________________________________________________________|             
   Lymph Node                              |    +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +     +     +  +|             
      Mediastinal, Congestion              |                                                          3               |             
      Pancreatic, Fibrosis, Focal          |                                        2                                 |             
                                            __________________________________________________________________________|             
   Lymph Node, Mesenteric                  |    +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +     +     +  +|             
      Congestion                           |                               1                                          |             
      Hyperplasia, Re Cell                 |                                                                          |             
                                            __________________________________________________________________________|             
   Spleen                                  |    +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +     +     +  +|             
      Congestion                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  85                                                               
NTP Experiment-Test: 05705-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 11:37:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 5| 6| 7| 6| 3| 4| 6| 5| 7| 5| 7| 6| 6| 7| 1| 3| 4| 7| 7| 1| 4| 4| 6| 7|             
                             DAY ON TEST   | 8| 2| 9| 2| 3| 3| 5| 5| 7| 3| 1| 3| 6| 8| 3| 8| 6| 5| 3| 1| 8| 1| 5| 7| 3|             
                                           | 3| 8| 8| 9| 8| 9| 6| 3| 7| 0| 9| 1| 9| 2| 0| 3| 6| 7| 2| 8| 3| 7| 6| 2| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    30 MG/KG                               | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
     MALE                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 HEMATOPOIETIC SYSTEM - cont               |                                                                          |             
                                           |                                                                          |             
      Fibrosis                             |                                        2                                 |             
      Hematopoietic Cell Proliferation     |                                                                          |             
          Granulocytic                     |                                                                          |             
                                            __________________________________________________________________________|             
   Thymus                                  |    +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  I     +     +  +|             
      Congestion                           |                                                                2         |             
      Cyst, Multiple                       |                                                                      2   |             
      Hyperplasia                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 INTEGUMENTARY SYSTEM                      |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Mammary Gland                           |    +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +     +     +  +|             
      Hyperplasia, Cystic                  |          1                                                               |             
      Hyperplasia                          |             1              2  1        2  1              2               |             
      Pigmentation                         |                                                                          |             
                                            __________________________________________________________________________|             
   Skin                                    |    +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +     +     +  +|             
      Inflammation, Chronic, Focal         |                                                                          |             
      Face, Inflammation, Acute, Focal     |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 MUSCULOSKELETAL SYSTEM                    |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Bone                                    |    +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +     +     +  +|             
      Fibrous Osteodystrophy               |       4                    X                             3               |             
                                            __________________________________________________________________________|             
   Skeletal Muscle                         |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 NERVOUS SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Brain                                   |    +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +     +     +  +|             
      Hemorrhage, Focal                    |                                        1                                 |             
      Hydrocephalus                        |                                     1                                    |             
      Cerebellum, Pigmentation, Focal      |                                     2                                    |             
      Thalamus, Inflammation, Chronic,     |                                                                          |             
           Focal                           |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM                        |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Lung                                    |    +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +     +     +  +|             
      Congestion                           |    2                                            3  1           2         |             
      Inflammation, Chronic                |                            1                                             |             
      Alveolus, Infiltration Cellular,     |                                                                          |             
           Histiocyte                      |                                                          2               |             
      Bronchiole, Inflammation, Chronic    |                                                                          |             
          Active, Multifocal               |                                                                          |             
      Peribronchial, Infiltration Cellular,|                                                                          |             
           Lymphocyte                      |                                                                          |             
      Perivascular, Inflammation, Chronic  |                                  1        1                              |             
      Pleura, Fibrosis, Focal              |                                                                          |             
      Pleura, Infiltration Cellular, Focal,|                                                                          |             
           Histiocyte                      |                                                                      2   |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  86                                                               
NTP Experiment-Test: 05705-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 11:37:15  
                                                                                                                                    
 _____________________________________________________________________________________________________________________              
                                           | 1| 5| 6| 7| 6| 3| 4| 6| 5| 7| 5| 7| 6| 6| 7| 1| 3| 4| 7| 7| 1| 4| 4| 6| 7|             
                             DAY ON TEST   | 8| 2| 9| 2| 3| 3| 5| 5| 7| 3| 1| 3| 6| 8| 3| 8| 6| 5| 3| 1| 8| 1| 5| 7| 3|             
                                           | 3| 8| 8| 9| 8| 9| 6| 3| 7| 0| 9| 1| 9| 2| 0| 3| 6| 7| 2| 8| 3| 7| 6| 2| 1|             
 _____________________________________________________________________________________________________________________|             
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|             
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6|             
    30 MG/KG                               | 2| 2| 2| 2| 2| 3| 3| 3| 3| 3| 4| 4| 4| 4| 4| 5| 5| 5| 5| 5| 6| 6| 6| 6| 6|             
     MALE                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|             
 _____________________________________________________________________________________________________________________|             
 RESPIRATORY SYSTEM - cont                 |                                                                          |             
                                           |                                                                          |             
      Subpleura, Inflammation, Chronic     |                                                       2                  |             
                                            __________________________________________________________________________|             
   Nose                                    |    +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +     +     +  +|             
      Autolysis                            |                                                                3         |             
      Congestion                           |                                                 2                        |             
      Fungus                               |                            X                             X               |             
      Metaplasia, Squamous                 |                      2              2  2              2  2               |             
      Mucosa, Inflammation, Acute          |       1                 1  4                                   2     1   |             
      Mucosa, Inflammation, Chronic Active |                      3           2  2  2  1           2  3               |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Acute                           |                                                                          |             
      Nasolacrimal Duct, Inflammation,     |                                                                          |             
           Chronic                         |                                                                         1|             
      Vomeronasal Organ, Inflammation,     |                                                                          |             
           Acute                           |                                                                          |             
                                            __________________________________________________________________________|             
   Trachea                                 |    +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +     +     +  +|             
      Inflammation, Chronic                |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 SPECIAL SENSES SYSTEM                     |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Eye                                     |                                  +                                       |             
      Bilateral, Lens, Cataract            |                                  3                                       |             
      Lens, Cataract                       |                                                                          |             
      Retina, Degeneration                 |                                                                          |             
      Sclera, Mineralization, Focal        |                                                                          |             
                                            __________________________________________________________________________|             
   Zymbal's Gland                          |                                                                          |             
 _____________________________________________________________________________________________________________________|             
 URINARY SYSTEM                            |                                                                          |             
                                           |                                                                          |             
                                            __________________________________________________________________________|             
   Kidney                                  |    +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +     +     +  +|             
      Congestion                           |                                                                          |             
      Nephropathy                          |    2  4  4  2        4  2  4  2  4  2  3  3     1  1  3  4           3  4|             
      Pelvis, Transitional Epithelium,     |                                                                          |             
           Hyperplasia                     |          2           2                                                   |             
      Renal Tubule, Epithelium,            |                                                                          |             
          Pigmentation                     |                                                                          |             
                                            __________________________________________________________________________|             
   Urinary Bladder                         |    +  +  +  +  +     +  +  +  +  +  +  +  +     +  +  +  +     +     +  +|             
      Inflammation, Acute                  |                            3                                             |             
      Transitional Epithelium, Hyperplasia,|                                                                          |             
           Focal, Papillary                |          3                                                               |             
 _____________________________________________________________________________________________________________________|             
                                                             Page  87                                                               
NTP Experiment-Test: 05705-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 11:37:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 6| 3| 4| 5| 7| 7| 7| 1| 4| 5| 7| 7| 3| 3| 5| 5| 7|              |            |
                             DAY ON TEST   | 9| 3| 2| 6| 4| 5| 6| 3| 3| 3| 8| 5| 3| 3| 3| 3| 5| 1| 3| 2|              |            |
                                           | 2| 2| 9| 6| 4| 6| 4| 0| 2| 1| 3| 0| 5| 1| 0| 6| 9| 3| 2| 9|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|              |      A     |
    30 MG/KG                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|              |      L     |
     MALE                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM                         |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Esophagus                               | +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +               |  53        |
      Wall, Inflammation, Chronic          |                                                 2                        |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large                         | +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +               |  53        |
                                            __________________________________________________________________________|____________|
   Intestine Large, Cecum                  | +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +               |  53        |
      Inflammation, Acute                  |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Large, Colon                  | +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +               |  53        |
      Parasite Metazoan                    |          X                 X              X     X                        |     12     |
                                            __________________________________________________________________________|____________|
   Intestine Large, Rectum                 | +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +               |  52        |
      Parasite Metazoan                    |                                                                          |      2     |
                                            __________________________________________________________________________|____________|
   Intestine Small                         | +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +               |  53        |
      Perivascular, Inflammation, Chronic  |                                                          3               |      1  3.0|
      Serosa, Inflammation, Chronic        |                                                          3               |      1  3.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Duodenum               | +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +               |  53        |
      Inflammation, Chronic                |                                                          3               |      1  3.0|
      Necrosis, Acute, Focal               |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Intestine Small, Ileum                  | +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +               |  51        |
      Autolysis                            |                                  1                                       |      1  1.0|
      Parasite Metazoan                    |                                                                          |      1     |
                                            __________________________________________________________________________|____________|
   Intestine Small, Jejunum                | +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +               |  52        |
                                            __________________________________________________________________________|____________|
   Liver                                   | +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +               |  53        |
      Basophilic Focus                     |                         X  X              X              1               |      5  1.0|
      Basophilic Focus, Multiple           |                                                                          |      3     |
      Clear Cell Focus                     |                                                                          |      1     |
      Congestion                           |          1                                                               |      1  1.0|
      Cytoplasmic Alteration, Focal        |    2  2                                                                  |      4  2.3|
      Inflammation, Acute, Multifocal      |                                                                          |      1  1.0|
      Necrosis, Acute, Focal               |                            2                                             |      3  1.3|
      Vacuolization Cytoplasmic, Focal     |                         2                                                |      2  2.5|
      Bile Duct, Hyperplasia               |                      2  1  2           2  1        1     1               |     17  1.5|
      Centrilobular, Fatty Change          |                                  2                                       |      1  2.0|
      Hepatocyte, Degeneration, Cystic,    |                                                                          |            |
           Focal                           |                                           2                              |      2  2.0|
      Hepatocyte, Hypertrophy, Focal       |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Mesentery                               |                                  +     +                                 |   2        |
      Inflammation, Chronic                |                                        2                                 |      1  2.0|
                                            __________________________________________________________________________|____________|
   Pancreas                                | +  +  +  +  +     +  +  +  +     I  +  +  +  +  +  +  +  +               |  52        |
      Atrophy, Focal                       | 1  1              2  2                             1     2               |     14  1.4|
      Infiltration Cellular, Focal,        |                                                                          |            |
          Lymphocyte                       |                                                 1                        |      1  1.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  88                                                               
NTP Experiment-Test: 05705-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 11:37:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 6| 3| 4| 5| 7| 7| 7| 1| 4| 5| 7| 7| 3| 3| 5| 5| 7|              |            |
                             DAY ON TEST   | 9| 3| 2| 6| 4| 5| 6| 3| 3| 3| 8| 5| 3| 3| 3| 3| 5| 1| 3| 2|              |            |
                                           | 2| 2| 9| 6| 4| 6| 4| 0| 2| 1| 3| 0| 5| 1| 0| 6| 9| 3| 2| 9|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|              |      A     |
    30 MG/KG                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|              |      L     |
     MALE                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ALIMENTARY SYSTEM - cont                  |                                                                          |            |
                                           |                                                                          |            |
      Duct, Ectasia, Focal                 |                                           1                              |      1  1.0|
      Perivascular, Inflammation, Chronic  |                                                          2               |      2  2.0|
                                            __________________________________________________________________________|____________|
   Salivary Glands                         | +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +               |  53        |
      Inflammation, Chronic                |             3                                   1                        |      2  2.0|
      Duct, Inflammation, Chronic Active   |                                                                          |      1  1.0|
      Periductular, Inflammation, Chronic  |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Stomach                                 | +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +               |  53        |
      Perivascular, Inflammation, Chronic  |                                                          2               |      1  2.0|
      Serosa, Inflammation, Chronic        |                                                          2               |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Forestomach                    | +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +               |  53        |
      Inflammation, Acute                  |    3                                                                     |      3  2.7|
      Inflammation, Chronic                |                                                          2               |      1  2.0|
      Inflammation, Chronic Active         |                                                                          |      1  3.0|
      Mineralization                       |                                                                          |      2  2.0|
      Epithelium, Hyperplasia              |                                                                          |      2  1.5|
      Serosa, Inflammation, Chronic        |                                        2                                 |      1  2.0|
                                            __________________________________________________________________________|____________|
   Stomach, Glandular                      | +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +               |  53        |
      Hemorrhage, Focal                    |                      1                                                   |      1  1.0|
      Infiltration Cellular, Focal,        |                                                                          |            |
          Lymphocyte                       |          2                                                               |      4  2.0|
      Inflammation, Chronic                |                                                                          |      1  2.0|
      Mineralization                       |                                                                          |      3  2.3|
      Necrosis, Focal                      |                                                                          |      2  2.0|
                                            __________________________________________________________________________|____________|
   Tongue                                  |                   +                             +                        |   3        |
      Epithelium, Hyperplasia, Focal       |                   3                                                      |      2  3.0|
 _____________________________________________________________________________________________________________________|            |
 CARDIOVASCULAR SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Blood Vessel                            | +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +               |  52        |
      Aorta, Mineralization                |                                                                          |      2  2.5|
                                            __________________________________________________________________________|____________|
   Heart                                   | +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +               |  53        |
      Inflammation, Chronic                |    2  3  3  1     2  2  2  2     2     2  2  1  1  1  1  2               |     46  1.7|
      Mineralization                       |                                                                          |      2  3.0|
      Atrium Left, Thrombosis              |                                                                          |      3  3.0|
      Perivascular, Inflammation, Chronic  |                                                                          |      1  3.0|
 _____________________________________________________________________________________________________________________|            |
 ENDOCRINE SYSTEM                          |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Adrenal Gland                           | +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +               |  53        |
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Cortex                   | +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +               |  53        |
      Hemorrhage, Focal                    |                                                                          |      1  2.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  89                                                               
NTP Experiment-Test: 05705-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 11:37:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 6| 3| 4| 5| 7| 7| 7| 1| 4| 5| 7| 7| 3| 3| 5| 5| 7|              |            |
                             DAY ON TEST   | 9| 3| 2| 6| 4| 5| 6| 3| 3| 3| 8| 5| 3| 3| 3| 3| 5| 1| 3| 2|              |            |
                                           | 2| 2| 9| 6| 4| 6| 4| 0| 2| 1| 3| 0| 5| 1| 0| 6| 9| 3| 2| 9|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|              |      A     |
    30 MG/KG                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|              |      L     |
     MALE                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 ENDOCRINE SYSTEM - cont                   |                                                                          |            |
                                           |                                                                          |            |
      Hyperplasia, Focal                   |       1           1     2  2        2  2  2              2               |     12  1.8|
      Hypertrophy, Focal                   |                                                                          |      3  1.7|
      Vacuolization Cytoplasmic, Focal     |    1                 2                                                   |      5  1.8|
                                            __________________________________________________________________________|____________|
   Adrenal Gland, Medulla                  | +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +               |  53        |
      Hyperplasia, Focal                   |    2                                                                     |      7  1.7|
      Mineralization, Focal                |                                                                          |      1  3.0|
      Thrombosis                           |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Islets, Pancreatic                      | +  +  +  +  +     +  +  +  +     I  +  +  +  +  +  +  +  +               |  52        |
                                            __________________________________________________________________________|____________|
   Parathyroid Gland                       | +  +  M  M  +     +  +  +  +     +  M  +  +  +  M  M  +  +               |  37        |
      Hyperplasia                          |                                                                          |      4  2.0|
                                            __________________________________________________________________________|____________|
   Pituitary Gland                         | +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +               |  53        |
      Pars Distalis, Angiectasis           |                                                                          |      1  2.0|
      Pars Distalis, Cyst                  |                                              1                           |      1  1.0|
      Pars Distalis, Hyperplasia           |          2              2           1     1                              |      6  1.7|
                                            __________________________________________________________________________|____________|
   Thyroid Gland                           | +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +               |  53        |
      C-Cell, Hyperplasia                  |       1              2                 1                                 |      4  1.3|
 _____________________________________________________________________________________________________________________|            |
 GENERAL BODY SYSTEM                       |                                                                          |            |
                                           |                                                                          |            |
    None                                   |                                                                          |            |
 _____________________________________________________________________________________________________________________|            |
 GENITAL SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Epididymis                              | +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +               |  52        |
                                            __________________________________________________________________________|____________|
   Penis                                   |                                                                          |   1        |
      Inflammation, Acute                  |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Preputial Gland                         | +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +               |  52        |
      Ectasia                              |                                                                          |      1  3.0|
      Inflammation, Acute                  |                         3                          3                     |      8  2.3|
      Inflammation, Chronic                |    1  2                    2        1           1     1                  |     16  1.2|
                                            __________________________________________________________________________|____________|
   Prostate                                | +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +               |  53        |
      Hyperplasia, Focal                   |                                                                          |      1  2.0|
      Inflammation, Acute                  |                   1                 3                                    |      4  2.0|
      Inflammation, Chronic                |                                                 1                        |      2  2.0|
      Mineralization                       |       1                                                                  |      2  1.5|
                                            __________________________________________________________________________|____________|
   Seminal Vesicle                         | M  M  M  M  M     M  M  M  M     M  +  M  M  M  M  M  M  M               |   3        |
                                            __________________________________________________________________________|____________|
   Testes                                  | +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +               |  52        |
      Atrophy                              |             3                                                            |      1  3.0|
      Hemorrhage                           |                                                                          |      1  4.0|
      Infarct, Diffuse                     |                                        4                                 |      1  4.0|
      Interstitial Cell, Hyperplasia       |                                                 1                        |      6  1.5|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  90                                                               
NTP Experiment-Test: 05705-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 11:37:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 6| 3| 4| 5| 7| 7| 7| 1| 4| 5| 7| 7| 3| 3| 5| 5| 7|              |            |
                             DAY ON TEST   | 9| 3| 2| 6| 4| 5| 6| 3| 3| 3| 8| 5| 3| 3| 3| 3| 5| 1| 3| 2|              |            |
                                           | 2| 2| 9| 6| 4| 6| 4| 0| 2| 1| 3| 0| 5| 1| 0| 6| 9| 3| 2| 9|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|              |      A     |
    30 MG/KG                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|              |      L     |
     MALE                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 GENITAL SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Seminiferous Tubule, Degeneration    |                                                                          |      1  4.0|
 _____________________________________________________________________________________________________________________|            |
 HEMATOPOIETIC SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone Marrow                             | +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +               |  52        |
      Hypoplasia                           |                                                                          |      2  3.0|
      Myelofibrosis                        |                                                                          |      2  2.0|
      Myeloid Cell, Hyperplasia            |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node                              | +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +               |  53        |
      Mediastinal, Congestion              |                                                                          |      2  2.5|
      Pancreatic, Fibrosis, Focal          |                                                                          |      1  2.0|
                                            __________________________________________________________________________|____________|
   Lymph Node, Mesenteric                  | +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +               |  53        |
      Congestion                           |                                                                          |      1  1.0|
      Hyperplasia, Re Cell                 |                                           2                              |      1  2.0|
                                            __________________________________________________________________________|____________|
   Spleen                                  | +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +               |  53        |
      Congestion                           |                         2              3                                 |      2  2.5|
      Fibrosis                             |                                                                          |      1  2.0|
      Hematopoietic Cell Proliferation     |                                                                          |            |
          Granulocytic                     |                                                                          |      1  3.0|
                                            __________________________________________________________________________|____________|
   Thymus                                  | +  +  +  +  +     I  +  +  +     +  +  +  +  +  I  +  +  +               |  50        |
      Congestion                           |                      2                                                   |      2  2.0|
      Cyst, Multiple                       |          1                                                               |      3  1.7|
      Hyperplasia                          |             2                                2                           |      2  2.0|
 _____________________________________________________________________________________________________________________|            |
 INTEGUMENTARY SYSTEM                      |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Mammary Gland                           | +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +               |  53        |
      Hyperplasia, Cystic                  |                                                                          |      2  1.5|
      Hyperplasia                          |                                                                          |      9  1.4|
      Pigmentation                         |                            2                                             |      1  2.0|
                                            __________________________________________________________________________|____________|
   Skin                                    | +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +               |  53        |
      Inflammation, Chronic, Focal         |                                                                          |      1  3.0|
      Face, Inflammation, Acute, Focal     |                      2                                                   |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 MUSCULOSKELETAL SYSTEM                    |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Bone                                    | +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +               |  52        |
      Fibrous Osteodystrophy               |                                                                          |      3  3.5|
                                            __________________________________________________________________________|____________|
   Skeletal Muscle                         |                                  +                                       |   1        |
 _____________________________________________________________________________________________________________________|            |
 NERVOUS SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Brain                                   | +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +               |  53        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  91                                                               
NTP Experiment-Test: 05705-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 11:37:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 6| 3| 4| 5| 7| 7| 7| 1| 4| 5| 7| 7| 3| 3| 5| 5| 7|              |            |
                             DAY ON TEST   | 9| 3| 2| 6| 4| 5| 6| 3| 3| 3| 8| 5| 3| 3| 3| 3| 5| 1| 3| 2|              |            |
                                           | 2| 2| 9| 6| 4| 6| 4| 0| 2| 1| 3| 0| 5| 1| 0| 6| 9| 3| 2| 9|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|              |      A     |
    30 MG/KG                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|              |      L     |
     MALE                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 NERVOUS SYSTEM - cont                     |                                                                          |            |
                                           |                                                                          |            |
      Hemorrhage, Focal                    |                                                                          |      1  1.0|
      Hydrocephalus                        |                                                                          |      1  1.0|
      Cerebellum, Pigmentation, Focal      |                                                                          |      1  2.0|
      Thalamus, Inflammation, Chronic,     |                                                                          |            |
           Focal                           |                                                                          |      1  2.0|
 _____________________________________________________________________________________________________________________|            |
 RESPIRATORY SYSTEM                        |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Lung                                    | +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +               |  53        |
      Congestion                           |          2  2                                2                           |     10  2.0|
      Inflammation, Chronic                |                                                                          |      4  1.0|
      Alveolus, Infiltration Cellular,     |                                                                          |            |
           Histiocyte                      |                                                                          |      1  2.0|
      Bronchiole, Inflammation, Chronic    |                                                                          |            |
          Active, Multifocal               |                      2                                                   |      1  2.0|
      Peribronchial, Infiltration Cellular,|                                                                          |            |
           Lymphocyte                      |                                                 1                        |      1  1.0|
      Perivascular, Inflammation, Chronic  |                                                                          |      2  1.0|
      Pleura, Fibrosis, Focal              |                                                                          |      1  1.0|
      Pleura, Infiltration Cellular, Focal,|                                                                          |            |
           Histiocyte                      |                                                                          |      1  2.0|
      Subpleura, Inflammation, Chronic     |                         2                                                |      2  2.0|
                                            __________________________________________________________________________|____________|
   Nose                                    | +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +               |  53        |
      Autolysis                            |          2                                                               |      3  2.7|
      Congestion                           |                                                                          |      2  2.0|
      Fungus                               |                                  X                       X               |      5     |
      Metaplasia, Squamous                 |                         2                                                |      6  2.0|
      Mucosa, Inflammation, Acute          |                                  3                 3  2                  |      9  2.1|
      Mucosa, Inflammation, Chronic Active |    3  3     3        2  3                    3           3               |     15  2.6|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Acute                           |                                                          4               |      1  4.0|
      Nasolacrimal Duct, Inflammation,     |                                                                          |            |
           Chronic                         |                                           2                              |      2  1.5|
      Vomeronasal Organ, Inflammation,     |                                                                          |            |
           Acute                           |                                                                          |      1  1.0|
                                            __________________________________________________________________________|____________|
   Trachea                                 | +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +               |  53        |
      Inflammation, Chronic                |                                           2              1               |      2  1.5|
 _____________________________________________________________________________________________________________________|            |
 SPECIAL SENSES SYSTEM                     |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Eye                                     |                                           +                              |   3        |
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  92                                                               
NTP Experiment-Test: 05705-02                  NONNEOPLASTIC LESIONS BY INDIVIDUAL ANIMAL                         Report: PEIRPT09
Study Type: CHRONIC                                       MONOCHLOROACETIC ACID                                   Date: 04/29/97  
Route: GAVAGE                                                                                                     Time: 11:37:15  
                                                                                                                                    
 __________________________________________________________________________________________________________________________________ 
                                           | 4| 7| 7| 6| 3| 4| 5| 7| 7| 7| 1| 4| 5| 7| 7| 3| 3| 5| 5| 7|              |            |
                             DAY ON TEST   | 9| 3| 2| 6| 4| 5| 6| 3| 3| 3| 8| 5| 3| 3| 3| 3| 5| 1| 3| 2|              |            |
                                           | 2| 2| 9| 6| 4| 6| 4| 0| 2| 1| 3| 0| 5| 1| 0| 6| 9| 3| 2| 9|              |      T (*) |
 _____________________________________________________________________________________________________________________|            |
                                           | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      O     |
   FISCHER 344 RATS MALE                   | 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0| 0|              |      T     |
                               ANIMAL ID   | 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 6| 7| 7| 7| 7| 7|              |      A     |
    30 MG/KG                               | 7| 7| 7| 7| 7| 8| 8| 8| 8| 8| 9| 9| 9| 9| 9| 0| 0| 0| 0| 0|              |      L     |
     MALE                                  | 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5| 1| 2| 3| 4| 5|              |            |
 __________________________________________________________________________________________________________________________________ 
 SPECIAL SENSES SYSTEM - cont              |                                                                          |            |
                                           |                                                                          |            |
      Bilateral, Lens, Cataract            |                                                                          |      1  3.0|
      Lens, Cataract                       |                                           4                              |      2  4.0|
      Retina, Degeneration                 |                                           4                              |      2  4.0|
      Sclera, Mineralization, Focal        |                                           2                              |      1  2.0|
                                            __________________________________________________________________________|____________|
   Zymbal's Gland                          |                                                    +                     |   1        |
 _____________________________________________________________________________________________________________________|            |
 URINARY SYSTEM                            |                                                                          |            |
                                           |                                                                          |            |
                                            __________________________________________________________________________|____________|
   Kidney                                  | +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +               |  53        |
      Congestion                           |                                                 1                        |      1  1.0|
      Nephropathy                          | 2  4  4  4  1     2  3  3  3           4  4  1     2  2  3               |     48  2.6|
      Pelvis, Transitional Epithelium,     |                                                                          |            |
           Hyperplasia                     |                                                                          |      2  2.0|
      Renal Tubule, Epithelium,            |                                                                          |            |
          Pigmentation                     |                                  3                                       |      1  3.0|
                                            __________________________________________________________________________|____________|
   Urinary Bladder                         | +  +  +  +  +     +  +  +  +     +  +  +  +  +  +  +  +  +               |  53        |
      Inflammation, Acute                  |                                                                          |      1  3.0|
      Transitional Epithelium, Hyperplasia,|                                                                          |            |
           Focal, Papillary                |                                                                          |      1  3.0|
 __________________________________________________________________________________________________________________________________ 
  * : Total animals with tissue examined microscopically; total animals with lesion and mean severity grade                         
  + : Tissue examined microscopically                M : Missing tissue                        1-4 : Lesion qualified as:           
  X : Lesion present but not qualified               A : Autolysis precludes examination               1) Minimal  3) Moderate      
  I : Insufficient tissue                        BLANK : Not examined                                  2) Mild     4) Marked        
                                                             Page  93                                                               
                             ------------------------------------------------------------                                           
                             ----------              END OF REPORT             ----------                                           
                             ------------------------------------------------------------