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TR 396 Rat Pathology Tables

NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11 
LAB: IRDC                                                      DATE: 09/18/94   
EXP: 05705                  MONOCHLOROACETIC ACID              TIME: 21:26:01   
TEST: 02              CAGES FROM 0000 TO LAST CAGE             PAGE:   1        
TEST TYPE: CHRONIC          ROUTE: GAVAGE                      NTP C#: 60231    
CONT: 05700-05                                                 CAS: 79-11-8     
PATHOLOGIST: P. HILDEBRANDT                                                     
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NTP           STATISTICAL ANALYSIS OF SURVIVAL DATA            REPORT: PEIRPT11
LAB: IRDC                                                      DATE: 09/18/94  
EXP: 05705                  MONOCHLOROACETIC ACID              TIME: 21:26:01  
TEST: 02              CAGES FROM 0000 TO LAST CAGE                             
TEST TYPE: CHRONIC          ROUTE: GAVAGE                      NTP C#: 60231   
CONT: 05700-05                                                 CAS: 79-11-8    
PATHOLOGIST: P. HILDEBRANDT                                                    

                               MONOCHLOROACETIC ACID


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE RATS
                       FIRST TERMINAL SACRIFICE AT 729 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = CONTROL                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 70     UNCENSORED DEATHS 25     CENSORED DEATHS 18   TERMINAL 27        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      291   350   436   447   506   512   575   584   584   585                 |
 |      621   629   631   656   674   679   691   691   693   705                 |
 |      714   715   718   725   728                                               |
 |  CENSORED DEATHS                                                               |
 |      183   183   183   183   183   183   183   183   183   183                 |
 |      456   456   456   456   456   456   456   538                             |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 15 MG/KG                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 70     UNCENSORED DEATHS 32     CENSORED DEATHS 17   TERMINAL 21        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      284   364   411   427   448   556   557   557   569   588                 |
 |      599   602   611   625   633   633   644   647   647   647                 |
 |      668   686   687   696   706   706   718   718   718   725                 |
 |      728   728                                                                 |
 |  CENSORED DEATHS                                                               |
 |      183   183   183   183   183   183   183   183   183   183                 |
 |      456   456   456   456   456   456   456                                   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 30 MG/KG                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 70     UNCENSORED DEATHS 35     CENSORED DEATHS 19   TERMINAL 16        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      336   339   344   351   366   450   457   477   486   492                 |
 |      513   519   522   528   532   535   556   564   564   577                 |
 |      624   632   632   638   642   653   657   666   669   672                 |
 |      682   690   698   718   718                                               |
 |  CENSORED DEATHS                                                               |
 |      183   183   183   183   183   183   183   183   183   183                 |
 |      359   417   456   456   456   456   456   456   456                       |
 |                                                                                |
 ==================================================================================

                               MONOCHLOROACETIC ACID


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                     MALE RATS
                       FIRST TERMINAL SACRIFICE AT 729 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   729 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |CONTROL    |   100.0 100.0 100.0  96.7  96.7  93.3  89.5  81.7  74.0  52.5      |
 |           |                                                                    |
 |           |                                                                    |
 |15 MG/KG   |   100.0 100.0 100.0  96.7  95.0  91.7  91.7  78.3  63.0  40.1      |
 |           |                                                                    |
 |           |                                                                    |
 |30 MG/KG   |   100.0 100.0 100.0  93.3  91.6  85.9  69.9  61.9  48.0  32.0      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                    DOSE                        |
 |                                                                                |
 |                                CONTROL          15 MG/KG         30 MG/KG      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       52.5%            40.1%            32.0%         |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=0.011          P=0.287          P=0.015       |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       605.6            610.4            557.1         |
 |NATURAL DEATHS (C)      |       (24.2)           (20.1)           (19.6)        |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       576.9            569.5            528.0         |
 |(STANDARD ERROR)        |       (23.4)           (23.1)           (22.3)        |
 |                        |                                                       |
 ==================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                               MONOCHLOROACETIC ACID


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE RATS
                       FIRST TERMINAL SACRIFICE AT 729 DAYS
                                                          


                          INDIVIDUAL SURVIVAL TIMES (DAYS)
 ==================================================================================
 |                                DOSE = CONTROL                                  |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 70     UNCENSORED DEATHS 16     CENSORED DEATHS 17   TERMINAL 37        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      215   344   520   529   558   565   595   626   637   653                 |
 |      672   675   690   691   693   693                                         |
 |  CENSORED DEATHS                                                               |
 |      183   183   183   183   183   183   183   183   183   183                 |
 |      456   456   456   456   456   456   456                                   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 15 MG/KG                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 70     UNCENSORED DEATHS 32     CENSORED DEATHS 19   TERMINAL 19        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      243   243   427   494   504   535   539   550   568   575                 |
 |      584   588   596   600   610   624   630   637   639   639                 |
 |      644   644   647   652   662   672   674   677   679   702                 |
 |      706   725                                                                 |
 |  CENSORED DEATHS                                                               |
 |      3     183   183   183   183   183   183   183   183   183                 |
 |      183   299   456   456   456   456   456   456   456                       |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                DOSE = 30 MG/KG                                 |
 |                             ---------------------                              |
 |                                                                                |
 |  TOTAL 70     UNCENSORED DEATHS 26     CENSORED DEATHS 18   TERMINAL 26        |
 |                                                                                |
 |  UNCENSORED DEATHS                                                             |
 |      253   257   283   294   331   340   351   458   497   512                 |
 |      539   568   582   593   597   599   616   647   662   679                 |
 |      682   682   703   717   722   724                                         |
 |  CENSORED DEATHS                                                               |
 |      183   183   183   183   183   183   183   183   183   183                 |
 |      270   456   456   456   456   456   456   456                             |
 |                                                                                |
 ==================================================================================

                               MONOCHLOROACETIC ACID


                       STATISTICAL ANALYSIS OF SURVIVAL DATA
                                    FEMALE RATS
                       FIRST TERMINAL SACRIFICE AT 729 DAYS


 ==================================================================================
 |               KAPLAN-MEIER SURVIVAL PROBABILITY ESTIMATES (%)                  |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |    DOSE                               TIME (DAYS)                              |
 |                 90   180   270   365   425   485   545   605   665   729 (A)   |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |           |                                                                    |
 |CONTROL    |   100.0 100.0  98.3  96.7  96.7  96.7  92.9  87.2  81.5  70.1      |
 |           |                                                                    |
 |           |                                                                    |
 |15 MG/KG   |   100.0 100.0  96.6  96.6  96.6  94.9  87.0  73.1  51.4  37.6      |
 |           |                                                                    |
 |           |                                                                    |
 |30 MG/KG   |   100.0 100.0  96.7  88.2  88.2  86.2  80.3  70.5  64.7  51.0      |
 |           |                                                                    |
 |           |                                                                    |
 ==================================================================================
 ==================================================================================
 |                           SURVIVAL SUMMARY STATISTICS                          |
 |                                                                                |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |                                                    DOSE                        |
 |                                                                                |
 |                                CONTROL          15 MG/KG         30 MG/KG      |
 |                                                                                |
 |--------------------------------------------------------------------------------|
 |SURVIVAL AT END OF STUDY|       70.1%            37.6%            51.0%         |
 |(KAPLAN-MEIER)          |                                                       |
 |                        |                                                       |
 |SIGNIFICANCE (B)        |       P=0.043          P=0.001          P=0.046       |
 |(LIFE TABLE)            |                                                       |
 |                        |                                                       |
 |MEAN DAY OF             |       584.8            590.9            534.2         |
 |NATURAL DEATHS (C)      |       (33.8)           (19.9)           (31.5)        |
 |(STANDARD ERROR)        |                                                       |
 |                        |                                                       |
 |MEAN LIFE SPAN (D)      |       590.7            544.1            544.8         |
 |(STANDARD ERROR)        |       (24.0)           (24.2)           (24.8)        |
 |                        |                                                       |
 ==================================================================================
                                    


       (A)  FIRST TERMINAL SACRIFICE
       (B)  THE FIRST ENTRY IS THE TREND TEST (TARONE, 1975) RESULT.
            SUBSEQUENT ENTRIES ARE THE RESULTS OF PAIRWISE TESTS
            (COX,1972).  NEGATIVE TRENDS ARE INDICATED BY "N".
       (C)  MEAN OF ALL UNCENSORED DEATHS PRIOR TO TERMINAL SACRIFICE
       (D)  MEAN OF ALL DEATHS (UNCENSORED, CENSORED, TERMINAL SACRIFICE)

                                                       MONOCHLOROACETIC ACID
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        CONTROL          = 1
                                                        15 MG/KG         = 2
                                                        30 MG/KG         = 3

------------------------------------------------------ SPECIES=RATS SEX=MALE -------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  100 + 1                                            21      3
      |                                              21      331 2       2   1
      |                                                        33        2 2 11
      |                                                         3 3        2  1 3       11      2
   90 +                                                                         33       1         1
      |                                                                          3  3              11
P     |                                                                             333         2 2 2
E     |                                                                               3  3          1  2  1
R  80 +                                                                                  3 3              11
C     |                                                                                                2 2 11
E     |                                                                                    33              21  1   1
N     |                                                                                     33
T  70 +                                                                                      3  3           222    1 1
      |                                                                                         33
S     |                                                                                          3 3                 1 1
U     |                                                                                            3       3  2   2    11
R  60 +                                                                                                    33     2 22  11
V     |                                                                                                              22  11
I     |                                                                                                     33        22
V     |                                                                                                      3 3       2 21 1
A  50 +
L     |                                                                                                        3  3
      |                                                                                                                  22
      |                                                                                                           3 3
   40 +                                                                                                             33    2 2
      |                                                                                                              33
      |                                                                                                               3  3
      |                                                                                                                  3  3
   30 +
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 19 obs hidden.

                                                       MONOCHLOROACETIC ACID
                                                    KAPLAN-MEIER SURVIVAL CURVES
                                                        CONTROL          = 1
                                                        15 MG/KG         = 2
                                                        30 MG/KG         = 3

----------------------------------------------------- SPECIES=RATS SEX=FEMALE ------------------------------------------------------

                                         Plot of SURVIVAL*WEEK.  Symbol is value of DOSE.

      |
      |
  100 + 1                                 1    2 3
      |                                   1    2 3   3         1           2               1
      |                                              33                    2          2    11
      |                                               3      33                       22    1   1
   90 +                                                       3 3                      2     2  11    1
      |                                                         3                3           2 2      1    1
P     |                                                                          3    3  3     2  2        11
E     |                                                                                  3   3    22        1  1  1
R  80 +                                                                                      3    322             11
C     |                                                                                           3 2 32           1 1
E     |                                                                                               33
N     |                                                                                                2 2
T  70 +                                                                                                3 2 2         1      1
      |                                                                                                  3 22 3  3
S     |                                                                                                     22   3 3
U     |                                                                                                            33
R  60 +                                                                                                             3  3
V     |                                                                                                      22        3 3
I     |                                                                                                       22         33
V     |                                                                                                        2 22
A  50 +                                                                                                           22      3 3
L     |
      |
      |                                                                                                            2   2
   40 +                                                                                                                2  2
      |                                                                                                                   2 2
      |
      |
   30 +
      |
      --+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+----------+--
        0         10         20         30         40         50         60         70         80         90         100        110

                                                                   WEEK

NOTE: 12 obs hidden.